FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:DGUOK-ACTG2 (FusionGDB2 ID:22494)

Fusion Gene Summary for DGUOK-ACTG2

check button Fusion gene summary
Fusion gene informationFusion gene name: DGUOK-ACTG2
Fusion gene ID: 22494
HgeneTgene
Gene symbol

DGUOK

ACTG2

Gene ID

1716

72

Gene namedeoxyguanosine kinaseactin gamma 2, smooth muscle
SynonymsMTDPS3|NCPH|PEOB4|dGKACT|ACTA3|ACTE|ACTL3|ACTSG|VSCM
Cytomap

2p13.1

2p13.1

Type of geneprotein-codingprotein-coding
Descriptiondeoxyguanosine kinase, mitochondrialactin, gamma-enteric smooth muscleactin, gamma 2, smooth muscle, entericactin-like proteinalpha-actin-3
Modification date2020031320200313
UniProtAcc

Q16854

P63267

Ensembl transtripts involved in fusion geneENST00000462685, ENST00000264093, 
ENST00000348222, ENST00000356837, 
ENST00000345517, ENST00000409731, 
ENST00000409624, ENST00000409918, 
Fusion gene scores* DoF score6 X 5 X 6=18012 X 15 X 8=1440
# samples 1020
** MAII scorelog2(10/180*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/1440*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DGUOK [Title/Abstract] AND ACTG2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDGUOK(74177859)-ACTG2(74129487), # samples:2
Anticipated loss of major functional domain due to fusion event.DGUOK-ACTG2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
DGUOK-ACTG2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDGUOK

GO:0046122

purine deoxyribonucleoside metabolic process

8706825


check buttonFusion gene breakpoints across DGUOK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ACTG2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-BT-A3PJ-01ADGUOKchr2

74177859

-ACTG2chr2

74129487

+
ChimerDB4BLCATCGA-BT-A3PJ-01ADGUOKchr2

74177859

+ACTG2chr2

74129487

+
ChimerDB4BRCATCGA-BH-A0AV-01ADGUOKchr2

74154179

+ACTG2chr2

74140612

+
ChimerDB4SARCTCGA-HB-A43Z-01ADGUOKchr2

74154179

+ACTG2chr2

74129487

+
ChimerDB4SARCTCGA-HB-A43Z-01ADGUOKchr2

74154179

+ACTG2chr2

74135800

+


Top

Fusion Gene ORF analysis for DGUOK-ACTG2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000462685ENST00000345517DGUOKchr2

74154179

+ACTG2chr2

74140612

+
3UTR-3CDSENST00000462685ENST00000345517DGUOKchr2

74154179

+ACTG2chr2

74135800

+
3UTR-3CDSENST00000462685ENST00000409731DGUOKchr2

74154179

+ACTG2chr2

74140612

+
3UTR-3CDSENST00000462685ENST00000409731DGUOKchr2

74154179

+ACTG2chr2

74135800

+
3UTR-intronENST00000462685ENST00000345517DGUOKchr2

74177859

+ACTG2chr2

74129487

+
3UTR-intronENST00000462685ENST00000345517DGUOKchr2

74154179

+ACTG2chr2

74129487

+
3UTR-intronENST00000462685ENST00000409624DGUOKchr2

74177859

+ACTG2chr2

74129487

+
3UTR-intronENST00000462685ENST00000409624DGUOKchr2

74154179

+ACTG2chr2

74140612

+
3UTR-intronENST00000462685ENST00000409624DGUOKchr2

74154179

+ACTG2chr2

74129487

+
3UTR-intronENST00000462685ENST00000409624DGUOKchr2

74154179

+ACTG2chr2

74135800

+
3UTR-intronENST00000462685ENST00000409731DGUOKchr2

74177859

+ACTG2chr2

74129487

+
3UTR-intronENST00000462685ENST00000409731DGUOKchr2

74154179

+ACTG2chr2

74129487

+
3UTR-intronENST00000462685ENST00000409918DGUOKchr2

74177859

+ACTG2chr2

74129487

+
3UTR-intronENST00000462685ENST00000409918DGUOKchr2

74154179

+ACTG2chr2

74140612

+
3UTR-intronENST00000462685ENST00000409918DGUOKchr2

74154179

+ACTG2chr2

74129487

+
3UTR-intronENST00000462685ENST00000409918DGUOKchr2

74154179

+ACTG2chr2

74135800

+
5CDS-intronENST00000264093ENST00000345517DGUOKchr2

74177859

+ACTG2chr2

74129487

+
5CDS-intronENST00000264093ENST00000345517DGUOKchr2

74154179

+ACTG2chr2

74129487

+
5CDS-intronENST00000264093ENST00000409624DGUOKchr2

74177859

+ACTG2chr2

74129487

+
5CDS-intronENST00000264093ENST00000409624DGUOKchr2

74154179

+ACTG2chr2

74140612

+
5CDS-intronENST00000264093ENST00000409624DGUOKchr2

74154179

+ACTG2chr2

74129487

+
5CDS-intronENST00000264093ENST00000409624DGUOKchr2

74154179

+ACTG2chr2

74135800

+
5CDS-intronENST00000264093ENST00000409731DGUOKchr2

74177859

+ACTG2chr2

74129487

+
5CDS-intronENST00000264093ENST00000409731DGUOKchr2

74154179

+ACTG2chr2

74129487

+
5CDS-intronENST00000264093ENST00000409918DGUOKchr2

74177859

+ACTG2chr2

74129487

+
5CDS-intronENST00000264093ENST00000409918DGUOKchr2

74154179

+ACTG2chr2

74140612

+
5CDS-intronENST00000264093ENST00000409918DGUOKchr2

74154179

+ACTG2chr2

74129487

+
5CDS-intronENST00000264093ENST00000409918DGUOKchr2

74154179

+ACTG2chr2

74135800

+
5CDS-intronENST00000348222ENST00000345517DGUOKchr2

74154179

+ACTG2chr2

74129487

+
5CDS-intronENST00000348222ENST00000409624DGUOKchr2

74154179

+ACTG2chr2

74140612

+
5CDS-intronENST00000348222ENST00000409624DGUOKchr2

74154179

+ACTG2chr2

74129487

+
5CDS-intronENST00000348222ENST00000409624DGUOKchr2

74154179

+ACTG2chr2

74135800

+
5CDS-intronENST00000348222ENST00000409731DGUOKchr2

74154179

+ACTG2chr2

74129487

+
5CDS-intronENST00000348222ENST00000409918DGUOKchr2

74154179

+ACTG2chr2

74140612

+
5CDS-intronENST00000348222ENST00000409918DGUOKchr2

74154179

+ACTG2chr2

74129487

+
5CDS-intronENST00000348222ENST00000409918DGUOKchr2

74154179

+ACTG2chr2

74135800

+
5CDS-intronENST00000356837ENST00000345517DGUOKchr2

74177859

+ACTG2chr2

74129487

+
5CDS-intronENST00000356837ENST00000345517DGUOKchr2

74154179

+ACTG2chr2

74129487

+
5CDS-intronENST00000356837ENST00000409624DGUOKchr2

74177859

+ACTG2chr2

74129487

+
5CDS-intronENST00000356837ENST00000409624DGUOKchr2

74154179

+ACTG2chr2

74140612

+
5CDS-intronENST00000356837ENST00000409624DGUOKchr2

74154179

+ACTG2chr2

74129487

+
5CDS-intronENST00000356837ENST00000409624DGUOKchr2

74154179

+ACTG2chr2

74135800

+
5CDS-intronENST00000356837ENST00000409731DGUOKchr2

74177859

+ACTG2chr2

74129487

+
5CDS-intronENST00000356837ENST00000409731DGUOKchr2

74154179

+ACTG2chr2

74129487

+
5CDS-intronENST00000356837ENST00000409918DGUOKchr2

74177859

+ACTG2chr2

74129487

+
5CDS-intronENST00000356837ENST00000409918DGUOKchr2

74154179

+ACTG2chr2

74140612

+
5CDS-intronENST00000356837ENST00000409918DGUOKchr2

74154179

+ACTG2chr2

74129487

+
5CDS-intronENST00000356837ENST00000409918DGUOKchr2

74154179

+ACTG2chr2

74135800

+
Frame-shiftENST00000264093ENST00000345517DGUOKchr2

74154179

+ACTG2chr2

74135800

+
Frame-shiftENST00000264093ENST00000409731DGUOKchr2

74154179

+ACTG2chr2

74135800

+
Frame-shiftENST00000348222ENST00000345517DGUOKchr2

74154179

+ACTG2chr2

74135800

+
Frame-shiftENST00000348222ENST00000409731DGUOKchr2

74154179

+ACTG2chr2

74135800

+
Frame-shiftENST00000356837ENST00000345517DGUOKchr2

74154179

+ACTG2chr2

74135800

+
Frame-shiftENST00000356837ENST00000409731DGUOKchr2

74154179

+ACTG2chr2

74135800

+
In-frameENST00000264093ENST00000345517DGUOKchr2

74154179

+ACTG2chr2

74140612

+
In-frameENST00000264093ENST00000409731DGUOKchr2

74154179

+ACTG2chr2

74140612

+
In-frameENST00000348222ENST00000345517DGUOKchr2

74154179

+ACTG2chr2

74140612

+
In-frameENST00000348222ENST00000409731DGUOKchr2

74154179

+ACTG2chr2

74140612

+
In-frameENST00000356837ENST00000345517DGUOKchr2

74154179

+ACTG2chr2

74140612

+
In-frameENST00000356837ENST00000409731DGUOKchr2

74154179

+ACTG2chr2

74140612

+
intron-intronENST00000348222ENST00000345517DGUOKchr2

74177859

+ACTG2chr2

74129487

+
intron-intronENST00000348222ENST00000409624DGUOKchr2

74177859

+ACTG2chr2

74129487

+
intron-intronENST00000348222ENST00000409731DGUOKchr2

74177859

+ACTG2chr2

74129487

+
intron-intronENST00000348222ENST00000409918DGUOKchr2

74177859

+ACTG2chr2

74129487

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for DGUOK-ACTG2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DGUOKchr274177859+ACTG2chr274129486+0.0188578420.9811421
DGUOKchr274154179+ACTG2chr274135799+0.0016307850.9983693
DGUOKchr274154179+ACTG2chr274140611+2.62E-081
DGUOKchr274154179+ACTG2chr274129486+5.01E-081
DGUOKchr274177859+ACTG2chr274129486+0.0188578420.9811421
DGUOKchr274154179+ACTG2chr274135799+0.0016307850.9983693
DGUOKchr274154179+ACTG2chr274140611+2.62E-081
DGUOKchr274154179+ACTG2chr274129486+5.01E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for DGUOK-ACTG2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:74177859/chr2:74129487)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DGUOK

Q16854

ACTG2

P63267

FUNCTION: Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine (PubMed:8692979, PubMed:8706825, PubMed:11687801, PubMed:17073823, PubMed:23043144). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs (By similarity). Widely used as target of antiviral and chemotherapeutic agents. {ECO:0000250|UniProtKB:Q9QX60, ECO:0000269|PubMed:11687801, ECO:0000269|PubMed:17073823, ECO:0000269|PubMed:23043144, ECO:0000269|PubMed:8692979, ECO:0000269|PubMed:8706825}.FUNCTION: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDGUOKchr2:74154179chr2:74140612ENST00000264093+17206_20847278.0Nucleotide bindingATP
HgeneDGUOKchr2:74154179chr2:74140612ENST00000264093+17254_25647278.0Nucleotide bindingATP
HgeneDGUOKchr2:74154179chr2:74140612ENST00000264093+1745_5347278.0Nucleotide bindingATP
HgeneDGUOKchr2:74154179chr2:74140612ENST00000348222+15206_20847190.0Nucleotide bindingATP
HgeneDGUOKchr2:74154179chr2:74140612ENST00000348222+15254_25647190.0Nucleotide bindingATP
HgeneDGUOKchr2:74154179chr2:74140612ENST00000348222+1545_5347190.0Nucleotide bindingATP


Top

Fusion Gene Sequence for DGUOK-ACTG2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for DGUOK-ACTG2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DGUOK-ACTG2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for DGUOK-ACTG2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource