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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADCY9-CLUAP1 (FusionGDB2 ID:2252)

Fusion Gene Summary for ADCY9-CLUAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADCY9-CLUAP1
Fusion gene ID: 2252
HgeneTgene
Gene symbol

ADCY9

CLUAP1

Gene ID

115

23059

Gene nameadenylate cyclase 9clusterin associated protein 1
SynonymsAC9|ACIXCFAP22|FAP22|IFT38
Cytomap

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionadenylate cyclase type 9ATP pyrophosphate-lyase 9adenylate cyclase type IXadenylyl cyclase 9type IX ATP pyrophosphate-lyaseclusterin-associated protein 1cilia and flagella associated protein 22flagellar associated protein 22, qilin-like protein, homolog
Modification date2020031320200313
UniProtAcc

O60503

Q96AJ1

Ensembl transtripts involved in fusion geneENST00000294016, ENST00000571889, 
ENST00000445795, ENST00000341633, 
ENST00000417763, ENST00000571025, 
ENST00000572600, ENST00000576634, 
Fusion gene scores* DoF score27 X 12 X 11=35647 X 8 X 4=224
# samples 279
** MAII scorelog2(27/3564*10)=-3.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/224*10)=-1.31550182572793
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADCY9 [Title/Abstract] AND CLUAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADCY9(4163751)-CLUAP1(3569903), # samples:2
ADCY9(4163751)-CLUAP1(3573158), # samples:2
Anticipated loss of major functional domain due to fusion event.ADCY9-CLUAP1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ADCY9-CLUAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ADCY9-CLUAP1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADCY9

GO:0006171

cAMP biosynthetic process

9628827|10987815

HgeneADCY9

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

9628827


check buttonFusion gene breakpoints across ADCY9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CLUAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-PG-A7D5-01AADCY9chr16

4163751

-CLUAP1chr16

3569903

+
ChimerDB4UCECTCGA-PG-A7D5-01AADCY9chr16

4163751

-CLUAP1chr16

3573158

+


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Fusion Gene ORF analysis for ADCY9-CLUAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000294016ENST00000445795ADCY9chr16

4163751

-CLUAP1chr16

3573158

+
5CDS-intronENST00000294016ENST00000445795ADCY9chr16

4163751

-CLUAP1chr16

3569903

+
Frame-shiftENST00000294016ENST00000341633ADCY9chr16

4163751

-CLUAP1chr16

3569903

+
Frame-shiftENST00000294016ENST00000341633ADCY9chr16

4163751

-CLUAP1chr16

3573158

+
Frame-shiftENST00000294016ENST00000417763ADCY9chr16

4163751

-CLUAP1chr16

3569903

+
Frame-shiftENST00000294016ENST00000417763ADCY9chr16

4163751

-CLUAP1chr16

3573158

+
Frame-shiftENST00000294016ENST00000571025ADCY9chr16

4163751

-CLUAP1chr16

3569903

+
Frame-shiftENST00000294016ENST00000571025ADCY9chr16

4163751

-CLUAP1chr16

3573158

+
Frame-shiftENST00000294016ENST00000572600ADCY9chr16

4163751

-CLUAP1chr16

3569903

+
Frame-shiftENST00000294016ENST00000572600ADCY9chr16

4163751

-CLUAP1chr16

3573158

+
Frame-shiftENST00000294016ENST00000576634ADCY9chr16

4163751

-CLUAP1chr16

3569903

+
Frame-shiftENST00000294016ENST00000576634ADCY9chr16

4163751

-CLUAP1chr16

3573158

+
intron-3CDSENST00000571889ENST00000341633ADCY9chr16

4163751

-CLUAP1chr16

3569903

+
intron-3CDSENST00000571889ENST00000341633ADCY9chr16

4163751

-CLUAP1chr16

3573158

+
intron-3CDSENST00000571889ENST00000417763ADCY9chr16

4163751

-CLUAP1chr16

3569903

+
intron-3CDSENST00000571889ENST00000417763ADCY9chr16

4163751

-CLUAP1chr16

3573158

+
intron-3CDSENST00000571889ENST00000571025ADCY9chr16

4163751

-CLUAP1chr16

3569903

+
intron-3CDSENST00000571889ENST00000571025ADCY9chr16

4163751

-CLUAP1chr16

3573158

+
intron-3CDSENST00000571889ENST00000572600ADCY9chr16

4163751

-CLUAP1chr16

3569903

+
intron-3CDSENST00000571889ENST00000572600ADCY9chr16

4163751

-CLUAP1chr16

3573158

+
intron-3CDSENST00000571889ENST00000576634ADCY9chr16

4163751

-CLUAP1chr16

3569903

+
intron-3CDSENST00000571889ENST00000576634ADCY9chr16

4163751

-CLUAP1chr16

3573158

+
intron-5UTRENST00000571889ENST00000445795ADCY9chr16

4163751

-CLUAP1chr16

3573158

+
intron-intronENST00000571889ENST00000445795ADCY9chr16

4163751

-CLUAP1chr16

3569903

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ADCY9-CLUAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ADCY9chr164163750-CLUAP1chr163569902+2.25E-050.99997747
ADCY9chr164163750-CLUAP1chr163573157+6.85E-080.9999999
ADCY9chr164163750-CLUAP1chr163569902+2.25E-050.99997747
ADCY9chr164163750-CLUAP1chr163573157+6.85E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ADCY9-CLUAP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:4163751/:3569903)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADCY9

O60503

CLUAP1

Q96AJ1

FUNCTION: Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}.FUNCTION: Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling. {ECO:0000250|UniProtKB:Q8R3P7}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ADCY9-CLUAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ADCY9-CLUAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADCY9-CLUAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADCY9-CLUAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource