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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DHCR24-TADA2B (FusionGDB2 ID:22523)

Fusion Gene Summary for DHCR24-TADA2B

Fusion gene summary

Fusion gene information	Fusion gene name: DHCR24-TADA2B
	Fusion gene ID: 22523
		Hgene	Tgene
	Gene symbol	DHCR24	TADA2B
	Gene ID	1718	93624
	Gene name	24-dehydrocholesterol reductase	transcriptional adaptor 2B
	Synonyms	DCE\|Nbla03646\|SELADIN1\|seladin-1	ADA2(beta)\|ADA2B
	Cytomap	1p32.3	4p16.1
	Type of gene	protein-coding	protein-coding
	Description	delta(24)-sterol reductase3 beta-hydroxysterol delta 24-reductasedesmosterol-to-cholesterol enzymediminuto/dwarf1 homologseladin 1selective AD indicator 1	transcriptional adapter 2-betaADA2-betaADA2-like protein betatranscriptional adaptor 2 (ADA2 homolog, yeast)-beta
	Modification date	20200320	20200313
	UniProtAcc	Q15392	.
	Ensembl transtripts involved in fusion gene	ENST00000371269, ENST00000535035, ENST00000537443,	ENST00000515646, ENST00000512388, ENST00000310074,
Fusion gene scores	* DoF score	21 X 16 X 8=2688	3 X 3 X 2=18
	# samples	22	3
	** MAII score	log2(22/2688*10)=-3.6109577092541 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: DHCR24 [Title/Abstract] AND TADA2B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DHCR24(55330976)-TADA2B(7055789), # samples:1
Anticipated loss of major functional domain due to fusion event.	DHCR24-TADA2B seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. DHCR24-TADA2B seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. DHCR24-TADA2B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DHCR24	GO:0043066	negative regulation of apoptotic process	15688385
Hgene	DHCR24	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	11007892

Fusion gene breakpoints across DHCR24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TADA2B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-NJ-A4YF-01A	DHCR24	chr1	55330976	-	TADA2B	chr4	7055789	+

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Fusion Gene ORF analysis for DHCR24-TADA2B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000371269	ENST00000515646	DHCR24	chr1	55330976	-	TADA2B	chr4	7055789	+
5CDS-5UTR	ENST00000535035	ENST00000515646	DHCR24	chr1	55330976	-	TADA2B	chr4	7055789	+
Frame-shift	ENST00000371269	ENST00000512388	DHCR24	chr1	55330976	-	TADA2B	chr4	7055789	+
Frame-shift	ENST00000535035	ENST00000512388	DHCR24	chr1	55330976	-	TADA2B	chr4	7055789	+
In-frame	ENST00000371269	ENST00000310074	DHCR24	chr1	55330976	-	TADA2B	chr4	7055789	+
In-frame	ENST00000535035	ENST00000310074	DHCR24	chr1	55330976	-	TADA2B	chr4	7055789	+
intron-3CDS	ENST00000537443	ENST00000310074	DHCR24	chr1	55330976	-	TADA2B	chr4	7055789	+
intron-3CDS	ENST00000537443	ENST00000512388	DHCR24	chr1	55330976	-	TADA2B	chr4	7055789	+
intron-5UTR	ENST00000537443	ENST00000515646	DHCR24	chr1	55330976	-	TADA2B	chr4	7055789	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000371269

DHCR24

chr1

55330976

ENST00000310074

TADA2B

chr4

7055789

5010

1119

2111

701

ENST00000535035

DHCR24

chr1

55330976

ENST00000310074

TADA2B

chr4

7055789

4871

980

1972

656

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000371269	ENST00000310074	DHCR24	chr1	55330976	-	TADA2B	chr4	7055789	+	0.001833139	0.9981668
ENST00000535035	ENST00000310074	DHCR24	chr1	55330976	-	TADA2B	chr4	7055789	+	0.001151983	0.99884796

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Fusion Genomic Features for DHCR24-TADA2B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
DHCR24	chr1	55330975	-	TADA2B	chr4	7055788	+	3.89E-06	0.99999607
DHCR24	chr1	55330975	-	TADA2B	chr4	7055788	+	3.89E-06	0.99999607

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DHCR24-TADA2B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:55330976/chr4:7055789)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DHCR24 Q15392	.
FUNCTION: Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis (PubMed:11519011, PubMed:21671375, PubMed:25637936, PubMed:22178193). In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress (PubMed:11007892, PubMed:22010141). Also protects against amyloid-beta peptide-induced apoptosis (PubMed:11007892). {ECO:0000269\|PubMed:11007892, ECO:0000269\|PubMed:11519011, ECO:0000269\|PubMed:21671375, ECO:0000269\|PubMed:22010141, ECO:0000269\|PubMed:22178193, ECO:0000269\|PubMed:25637936}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DHCR24

chr1:55330976

chr4:7055789

ENST00000371269

58_234

340

517.0

Domain

FAD-binding PCMH-type

Hgene

DHCR24

chr1:55330976

chr4:7055789

ENST00000371269

163_175

340

517.0

Nucleotide binding

FAD

Hgene

DHCR24

chr1:55330976

chr4:7055789

ENST00000371269

23_31

340

517.0

Topological domain

Lumenal

Hgene

DHCR24

chr1:55330976

chr4:7055789

ENST00000371269

32_52

340

517.0

Transmembrane

Helical

Tgene

TADA2B

chr1:55330976

chr4:7055789

ENST00000512388

65_118

346.0

Domain

SANT

Tgene

TADA2B

chr1:55330976

chr4:7055789

ENST00000515646

65_118

329.0

Domain

SANT

Tgene

TADA2B

chr1:55330976

chr4:7055789

ENST00000515646

3_49

329.0

Zinc finger

ZZ-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DHCR24

chr1:55330976

chr4:7055789

ENST00000371269

53_516

340

517.0

Topological domain

Cytoplasmic

Tgene

TADA2B

chr1:55330976

chr4:7055789

ENST00000310074

65_118

421.0

Domain

SANT

Tgene

TADA2B

chr1:55330976

chr4:7055789

ENST00000310074

3_49

421.0

Zinc finger

ZZ-type

Tgene

TADA2B

chr1:55330976

chr4:7055789

ENST00000512388

3_49

346.0

Zinc finger

ZZ-type

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Fusion Gene Sequence for DHCR24-TADA2B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>22523_22523_1_DHCR24-TADA2B_DHCR24_chr1_55330976_ENST00000371269_TADA2B_chr4_7055789_ENST00000310074_length(transcript)=5010nt_BP=1119nt
CCCGGGCTGTGGGCTACAGGCGCAGAGCGGGCCAGGCGCGGAGCTGGCGGCAGTGACAGGAGGCGCGAACCCGCAGCGCTTACCGCGCGG
CGCCGCACCATGGAGCCCGCCGTGTCGCTGGCCGTGTGCGCGCTGCTCTTCCTGCTGTGGGTGCGCCTGAAGGGGCTGGAGTTCGTGCTC
ATCCACCAGCGCTGGGTGTTCGTGTGCCTCTTCCTCCTGCCGCTCTCGCTTATCTTCGATATCTACTACTACGTGCGCGCCTGGGTGGTG
TTCAAGCTCAGCAGCGCTCCGCGCCTGCACGAGCAGCGCGTGCGGGACATCCAGAAGCAGGTGCGGGAATGGAAGGAGCAGGGTAGCAAG
ACCTTCATGTGCACGGGGCGCCCTGGCTGGCTCACTGTCTCACTACGTGTCGGGAAGTACAAGAAGACACACAAAAACATCATGATCAAC
CTGATGGACATTCTGGAAGTGGACACCAAGAAACAGATTGTCCGTGTGGAGCCCTTGGTGACCATGGGCCAGGTGACTGCCCTGCTGACC
TCCATTGGCTGGACTCTCCCCGTGTTGCCTGAGCTTGATGACCTCACAGTGGGGGGCTTGATCATGGGCACAGGCATCGAGTCATCATCC
CACAAGTACGGCCTGTTCCAACACATCTGCACTGCTTACGAGCTGGTCCTGGCTGATGGCAGCTTTGTGCGATGCACTCCGTCCGAAAAC
TCAGACCTGTTCTATGCCGTACCCTGGTCCTGTGGGACGCTGGGTTTCCTGGTGGCCGCTGAGATCCGCATCATCCCTGCCAAGAAGTAC
GTCAAGCTGCGTTTCGAGCCAGTGCGGGGCCTGGAGGCTATCTGTGCCAAGTTCACCCACGAGTCCCAGCGGCAGGAGAACCACTTCGTG
GAAGGGCTGCTCTACTCCCTGGATGAGGCTGTCATTATGACAGGGGTCATGACAGATGAGGCAGAGCCCAGCAAGCTGAATAGCATTGGC
AATTACTACAAGCCGTGGTTCTTTAAGCATGTGGAGAACTATCTGAAGACAAACCGAGAGGGCCTGGAGTACATTCCCTTGAGACACTAC
TACCACCGCCACACGCGCAGCATCTTCTGGGAGCTCCAGGAAGATATGGCTGCCCACGTTGGTGCTTCCCGGACTCCCCAAGAGGTGATG
GAGCATTACGTGAGCATGTACATCCACGGGAACCTGGGGAAGGCCTGCATCCCCGACACCATCCCCAACCGCGTGACAGACCACACCTGT
CCCAGCGGAGGCCCCCTCTCACCCAGCCTCACCACCCCGCTGCCCCCGCTGGACATCTCTGTGGCTGAGCAGCAGCAGCTGGGCTACATG
CCGCTGCGGGATGATTACGAGATCGAGTATGACCAGGATGCCGAGACGCTCATCAGCGGGCTCTCTGTCAACTATGATGACGACGACGTG
GAGATCGAGCTGAAGCGCGCCCACGTGGACATGTACGTGCGGAAGCTGAAAGAGAGACAGCGGCGGAAGAACATCGCCCGTGACTACAAT
CTGGTGCCAGCCTTCCTGGGGAAGGACAAGAAGGAGAAGGAAAAGGCGCTGAAGCGCAAGATCACCAAGGAGGAGAAGGAGCTGCGCCTG
AAGCTGAGGCCGCTGTACCAGTTCATGTCATGCAAGGAGTTTGATGACCTTTTTGAAAACATGCACAAAGAAAAAATGCTCCGGGCCAAG
ATCCGAGAACTGCAGCGGTACCGGCGAAACGGGATCACCAAGATGGAAGAGTCGGCAGAGTACGAGGCAGCGCGGCATAAACGGGAGAAG
AGGAAGGAGAACAAAAACCTAGCCGGCTCCAAACGGGGAAAGGAGGACGGCAAAGACAGCGAGTTCGCCGCCATTGAGAACCTTCCAGGC
TTCGAGCTCCTGTCAGATCGCGAGAAGGTGCTCTGCAGCTCTTTAAACTTGAGTCCAGCCCGCTACGTGACTGTGAAGACTATTATAATT
AAAGACCACCTCCAGAAGCGGCAAGGAATCCCCTCCAAAAGCCGCCTTCCTAGCTACCTGGACAAAGTCCTAAAGAAAAGGATTTTGAAT
TTCCTCACAGAAAGCGGCTGGATCTCCAGGGACGCGTCTTGAAGCTGAGACGCTTTGAAAGCCAGGGTGATGCTCAGACAGTGTGCCAGC
CAAAATGACTTGGGGGAGGGGAGCCGCTTCCCCACTGTTGCTCTTTTTTAAACAAATTGAGTTCCTTTTTTTAAGATAGAAATTCTTTTC
ATGGTCCTCTGAAAGAAGCAATAGTAACAATCTTATATTGGATCATGGGGGAAGCAAATGTGTGTATTTTAAGTGAGTTCCTGCGAGTCA
TACACTGCGATGATGCTCCGCCTTTACCCGTTCAGTTGGGAGCTTATTGTGAGATTGGATCATTTCCTTTTGAGTGTTCTTCTCTTTGGT
ACAAAAGCTATTGTGGGTGACAGGAGCAGTGTTTTCCTGCTGGACCCGCAAGCCACCAGCTATTTCCTGGTGACACAAGCTCTTCTCAGG
CGGGGCTGCCTGCAGGCTCCCGTTTTCTGAGCCCACGCTGCCCACAGCTGACCCCAGCGCAGCCCCGGGCACGCGGCACTTTACATGGGG
GCAGCTTGGGCCCAGACTCCTCCGCTGTGTAGCAGATGAGGAAAATCAGGCCAGAGGACAACAGGCTGGCGTTTTGTTGGGAACTGAAGA
GGAATCTGTTGAACACAGCGACCAGATGACCTTCCATTTCACCGGCGGCAGCAGTTTCAGCGTGCAGTTCCCAAACCCCAAAGCTGACCC
TGCGCCCCATTTGAATACGGCCAGAGCCTGCTGGTTCACTTTGGGTAGAGCCGTGCCTCTTGGGCAGGCTCCCATAGTGACCACGTCCCC
ACGAATGGGAAAGCACGTTAGTGGGAGGGACGTAGGACACGTGTGGACCGCCAGGCCCTCTCAGTCCATTTTCCGGGGCTGCTCGGTGCT
GCTGTTAAGACGTGAGTGCATTTCACTTGGAAGAACCCATTGTACAAAGTTCAAGGCTAAGAGTTCTGAATTCTGGCGTCAGCTTCCTCA
GGATTTTCTTCAGTTGCAAGTACCTTTCCACTGAAAATATGAGCATGCCCGCCTGGCTAGTAGGCATCTGTAAGAGTGTCGCCAGGCCCG
CGCCAGCTGAGGCCTCAGACTAGCCAGGCAAGAGCCGTCTGACCAGTTGGCTGGCGGTGGTTCTGGTGGAGCACGAGGGAGCCCGGGTGG
TGCCCTGAGCCTCGAGCTGCTCTCTGTCACTGTCTTGAATCAGACTCAGAAATGGCTTCTTCCCAGCCCTGCCTACAAGTTTTTCTCTGG
GGTCCTCTTTCAAGGATGTCCACGGTACCTTCCTCCTGAAACTTGAGGAAGTCTTTTGTCTTCCAGCTGCTCAGGGTTCTCTGGTCCAAG
ACCCTGCTTTAAAGAGAGTCTTTGGCGTGCTCAGACTCCAGCGCTCCGTTCTTCAAGGAGGTTGACTTGCCTCTCGGGCCCCGTAGGTAC
CAAGAGACTGTTTACCTCCCAGAATGTTTGGGCTTGAAGTTACATTAAAGTGAAGTTATTTGAAAGAAAGAAAACCTCATCATTTCTAAG
GATGACTTAATTACTGTGCCTTTTCCTTTCTTTTTACACATCCTACTGTCCCTTAGGGTAAAATTTTCAGCATTAAATAAAACATTTCAA
ATATATTGTATATGGCTTTAGTTGTAAACTATACTGCATGCTGACAGAGAAGCGCTCTTTTAGCTAAGCCCAGAACTTCTCTTTTGACAA
TAAAGTACTGAGCAGTGGTATCATGAGGGCCACCTCCACATTGTCCCCTGCAGAATAAATGCGGATGACAGAAAGCTTATGCTGTCTACC
ACTGAACAGTGATGGAGATGGTGCTAAGTTTTTACAGTTGTCTTAGCCCCAGTGGTTCTCAAGGTGGGGCTCCTGGCCCAGCAGCAGCAA
CTTGTTTGTTAGAATGCAGACGCGCAGGCCCCACCTGGCCTCCTGAATCAAAATGGTGTGCGGCAGGGTGCAGCGAGCTGTTTTCACGAG
GCCTCCAGGTGACTGGATGTAAGCTTGCTTGAGAACTATGGGTTTTAGCTATTCTGGTGTCTCCCTGATTTTCTACAGCGCCAGGATCCT
AGTTTGGTGAGGTTTTAAATTTAATCTTATTTTTATATAAAATGATTGCCAGACGTACTATATTAAGCTTGAAGAAGCAGAAGATCCCTG
TTAATGTGTATGGCCCAGGCCAAGAGCTGTCAAATGAAAAACTTTGTGCTGAAGCAGGTTTTTAGTATGTATATCTTTTTGATGGTATGA
AGAATTTATTTAGGCTTGACTGTTTTAAAACACCATAATGAATGTATAATTAATTTATGTTAAAGTATTAACCCTTTGTCACAAAGGAAT
GGTAATGTGATTGGCTGCCTGTTAGCCCATCGACTATTCCCGTCACGGTAGTCCTTACCTCTGTCGGCAGCTCAGAGCCTCCACATTTTT
ATATTTAATTCTCATGATAAATTAGCCACCATAATCCCATGGAATTAGGTCTTGTTAAAATCTAGTCCGGGCGCAGTGGCTCACGCCTGT
AATCCCAGCACTTTGGGAGGCCAAGGCGGGCTGATCACGAGGTCAAGAGATCGAGACCATCCTGGCCAACATGGTGAAACCCTGTCTCTA
CTAAAAATACAAAAATTAGCTGGGTGTGGTGGTGCATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGTAGGAGAATTGCTTGAACCTG
GGAGGCGGAGGTTGCGGTGAGCTGAGATCACGCCACTACACTCCAGCCTGGTGACAGAGCAAGACTCCATCTCAAAAAAAATCTAAGCAA
ACTATCTTTGAGTCAAAAAAAGTTGGATAACTCATCTATATTTGAAATAATGCTGTCTGAATGGCCAACATCCCAAGAATGTATTAAAAA

>22523_22523_1_DHCR24-TADA2B_DHCR24_chr1_55330976_ENST00000371269_TADA2B_chr4_7055789_ENST00000310074_length(amino acids)=701AA_BP=371
MWATGAERARRGAGGSDRRREPAALTARRRTMEPAVSLAVCALLFLLWVRLKGLEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFK
LSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSI
GWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVK
LRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAEPSKLNSIGNYYKPWFFKHVENYLKTNREGLEYIPLRHYYH
RHTRSIFWELQEDMAAHVGASRTPQEVMEHYVSMYIHGNLGKACIPDTIPNRVTDHTCPSGGPLSPSLTTPLPPLDISVAEQQQLGYMPL
RDDYEIEYDQDAETLISGLSVNYDDDDVEIELKRAHVDMYVRKLKERQRRKNIARDYNLVPAFLGKDKKEKEKALKRKITKEEKELRLKL
RPLYQFMSCKEFDDLFENMHKEKMLRAKIRELQRYRRNGITKMEESAEYEAARHKREKRKENKNLAGSKRGKEDGKDSEFAAIENLPGFE

--------------------------------------------------------------
>22523_22523_2_DHCR24-TADA2B_DHCR24_chr1_55330976_ENST00000535035_TADA2B_chr4_7055789_ENST00000310074_length(transcript)=4871nt_BP=980nt
AGCTGCGGTGCGGGGGCGGCCAGGACTTCCTGGGGGGGTGGGGAGCTGGCGTTGGAGAGGGGTTGGAACGAAACAAAAATGTGATGGGGG
CGGGGGAACAGAACAGGCAAAGTGCCCACTGTGTGCAGGGCATATGCGGGTACCTGGAGGGAGATGAAGAAGGGGAAGAGGGGGAGGTGC
GAAGCACTCAGGTGCGGGAATGGAAGGAGCAGGGTAGCAAGACCTTCATGTGCACGGGGCGCCCTGGCTGGCTCACTGTCTCACTACGTG
TCGGGAAGTACAAGAAGACACACAAAAACATCATGATCAACCTGATGGACATTCTGGAAGTGGACACCAAGAAACAGATTGTCCGTGTGG
AGCCCTTGGTGACCATGGGCCAGGTGACTGCCCTGCTGACCTCCATTGGCTGGACTCTCCCCGTGTTGCCTGAGCTTGATGACCTCACAG
TGGGGGGCTTGATCATGGGCACAGGCATCGAGTCATCATCCCACAAGTACGGCCTGTTCCAACACATCTGCACTGCTTACGAGCTGGTCC
TGGCTGATGGCAGCTTTGTGCGATGCACTCCGTCCGAAAACTCAGACCTGTTCTATGCCGTACCCTGGTCCTGTGGGACGCTGGGTTTCC
TGGTGGCCGCTGAGATCCGCATCATCCCTGCCAAGAAGTACGTCAAGCTGCGTTTCGAGCCAGTGCGGGGCCTGGAGGCTATCTGTGCCA
AGTTCACCCACGAGTCCCAGCGGCAGGAGAACCACTTCGTGGAAGGGCTGCTCTACTCCCTGGATGAGGCTGTCATTATGACAGGGGTCA
TGACAGATGAGGCAGAGCCCAGCAAGCTGAATAGCATTGGCAATTACTACAAGCCGTGGTTCTTTAAGCATGTGGAGAACTATCTGAAGA
CAAACCGAGAGGGCCTGGAGTACATTCCCTTGAGACACTACTACCACCGCCACACGCGCAGCATCTTCTGGGAGCTCCAGGAAGATATGG
CTGCCCACGTTGGTGCTTCCCGGACTCCCCAAGAGGTGATGGAGCATTACGTGAGCATGTACATCCACGGGAACCTGGGGAAGGCCTGCA
TCCCCGACACCATCCCCAACCGCGTGACAGACCACACCTGTCCCAGCGGAGGCCCCCTCTCACCCAGCCTCACCACCCCGCTGCCCCCGC
TGGACATCTCTGTGGCTGAGCAGCAGCAGCTGGGCTACATGCCGCTGCGGGATGATTACGAGATCGAGTATGACCAGGATGCCGAGACGC
TCATCAGCGGGCTCTCTGTCAACTATGATGACGACGACGTGGAGATCGAGCTGAAGCGCGCCCACGTGGACATGTACGTGCGGAAGCTGA
AAGAGAGACAGCGGCGGAAGAACATCGCCCGTGACTACAATCTGGTGCCAGCCTTCCTGGGGAAGGACAAGAAGGAGAAGGAAAAGGCGC
TGAAGCGCAAGATCACCAAGGAGGAGAAGGAGCTGCGCCTGAAGCTGAGGCCGCTGTACCAGTTCATGTCATGCAAGGAGTTTGATGACC
TTTTTGAAAACATGCACAAAGAAAAAATGCTCCGGGCCAAGATCCGAGAACTGCAGCGGTACCGGCGAAACGGGATCACCAAGATGGAAG
AGTCGGCAGAGTACGAGGCAGCGCGGCATAAACGGGAGAAGAGGAAGGAGAACAAAAACCTAGCCGGCTCCAAACGGGGAAAGGAGGACG
GCAAAGACAGCGAGTTCGCCGCCATTGAGAACCTTCCAGGCTTCGAGCTCCTGTCAGATCGCGAGAAGGTGCTCTGCAGCTCTTTAAACT
TGAGTCCAGCCCGCTACGTGACTGTGAAGACTATTATAATTAAAGACCACCTCCAGAAGCGGCAAGGAATCCCCTCCAAAAGCCGCCTTC
CTAGCTACCTGGACAAAGTCCTAAAGAAAAGGATTTTGAATTTCCTCACAGAAAGCGGCTGGATCTCCAGGGACGCGTCTTGAAGCTGAG
ACGCTTTGAAAGCCAGGGTGATGCTCAGACAGTGTGCCAGCCAAAATGACTTGGGGGAGGGGAGCCGCTTCCCCACTGTTGCTCTTTTTT
AAACAAATTGAGTTCCTTTTTTTAAGATAGAAATTCTTTTCATGGTCCTCTGAAAGAAGCAATAGTAACAATCTTATATTGGATCATGGG
GGAAGCAAATGTGTGTATTTTAAGTGAGTTCCTGCGAGTCATACACTGCGATGATGCTCCGCCTTTACCCGTTCAGTTGGGAGCTTATTG
TGAGATTGGATCATTTCCTTTTGAGTGTTCTTCTCTTTGGTACAAAAGCTATTGTGGGTGACAGGAGCAGTGTTTTCCTGCTGGACCCGC
AAGCCACCAGCTATTTCCTGGTGACACAAGCTCTTCTCAGGCGGGGCTGCCTGCAGGCTCCCGTTTTCTGAGCCCACGCTGCCCACAGCT
GACCCCAGCGCAGCCCCGGGCACGCGGCACTTTACATGGGGGCAGCTTGGGCCCAGACTCCTCCGCTGTGTAGCAGATGAGGAAAATCAG
GCCAGAGGACAACAGGCTGGCGTTTTGTTGGGAACTGAAGAGGAATCTGTTGAACACAGCGACCAGATGACCTTCCATTTCACCGGCGGC
AGCAGTTTCAGCGTGCAGTTCCCAAACCCCAAAGCTGACCCTGCGCCCCATTTGAATACGGCCAGAGCCTGCTGGTTCACTTTGGGTAGA
GCCGTGCCTCTTGGGCAGGCTCCCATAGTGACCACGTCCCCACGAATGGGAAAGCACGTTAGTGGGAGGGACGTAGGACACGTGTGGACC
GCCAGGCCCTCTCAGTCCATTTTCCGGGGCTGCTCGGTGCTGCTGTTAAGACGTGAGTGCATTTCACTTGGAAGAACCCATTGTACAAAG
TTCAAGGCTAAGAGTTCTGAATTCTGGCGTCAGCTTCCTCAGGATTTTCTTCAGTTGCAAGTACCTTTCCACTGAAAATATGAGCATGCC
CGCCTGGCTAGTAGGCATCTGTAAGAGTGTCGCCAGGCCCGCGCCAGCTGAGGCCTCAGACTAGCCAGGCAAGAGCCGTCTGACCAGTTG
GCTGGCGGTGGTTCTGGTGGAGCACGAGGGAGCCCGGGTGGTGCCCTGAGCCTCGAGCTGCTCTCTGTCACTGTCTTGAATCAGACTCAG
AAATGGCTTCTTCCCAGCCCTGCCTACAAGTTTTTCTCTGGGGTCCTCTTTCAAGGATGTCCACGGTACCTTCCTCCTGAAACTTGAGGA
AGTCTTTTGTCTTCCAGCTGCTCAGGGTTCTCTGGTCCAAGACCCTGCTTTAAAGAGAGTCTTTGGCGTGCTCAGACTCCAGCGCTCCGT
TCTTCAAGGAGGTTGACTTGCCTCTCGGGCCCCGTAGGTACCAAGAGACTGTTTACCTCCCAGAATGTTTGGGCTTGAAGTTACATTAAA
GTGAAGTTATTTGAAAGAAAGAAAACCTCATCATTTCTAAGGATGACTTAATTACTGTGCCTTTTCCTTTCTTTTTACACATCCTACTGT
CCCTTAGGGTAAAATTTTCAGCATTAAATAAAACATTTCAAATATATTGTATATGGCTTTAGTTGTAAACTATACTGCATGCTGACAGAG
AAGCGCTCTTTTAGCTAAGCCCAGAACTTCTCTTTTGACAATAAAGTACTGAGCAGTGGTATCATGAGGGCCACCTCCACATTGTCCCCT
GCAGAATAAATGCGGATGACAGAAAGCTTATGCTGTCTACCACTGAACAGTGATGGAGATGGTGCTAAGTTTTTACAGTTGTCTTAGCCC
CAGTGGTTCTCAAGGTGGGGCTCCTGGCCCAGCAGCAGCAACTTGTTTGTTAGAATGCAGACGCGCAGGCCCCACCTGGCCTCCTGAATC
AAAATGGTGTGCGGCAGGGTGCAGCGAGCTGTTTTCACGAGGCCTCCAGGTGACTGGATGTAAGCTTGCTTGAGAACTATGGGTTTTAGC
TATTCTGGTGTCTCCCTGATTTTCTACAGCGCCAGGATCCTAGTTTGGTGAGGTTTTAAATTTAATCTTATTTTTATATAAAATGATTGC
CAGACGTACTATATTAAGCTTGAAGAAGCAGAAGATCCCTGTTAATGTGTATGGCCCAGGCCAAGAGCTGTCAAATGAAAAACTTTGTGC
TGAAGCAGGTTTTTAGTATGTATATCTTTTTGATGGTATGAAGAATTTATTTAGGCTTGACTGTTTTAAAACACCATAATGAATGTATAA
TTAATTTATGTTAAAGTATTAACCCTTTGTCACAAAGGAATGGTAATGTGATTGGCTGCCTGTTAGCCCATCGACTATTCCCGTCACGGT
AGTCCTTACCTCTGTCGGCAGCTCAGAGCCTCCACATTTTTATATTTAATTCTCATGATAAATTAGCCACCATAATCCCATGGAATTAGG
TCTTGTTAAAATCTAGTCCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCTGATCACGAGGTCAAGAG
ATCGAGACCATCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGTGCATGCCTGTAGTCCC
AGCTACTTGGGAGGCTGAGGTAGGAGAATTGCTTGAACCTGGGAGGCGGAGGTTGCGGTGAGCTGAGATCACGCCACTACACTCCAGCCT
GGTGACAGAGCAAGACTCCATCTCAAAAAAAATCTAAGCAAACTATCTTTGAGTCAAAAAAAGTTGGATAACTCATCTATATTTGAAATA
ATGCTGTCTGAATGGCCAACATCCCAAGAATGTATTAAAAACAGCAACCCTGCCTACCGTTTTGATGACCTTTTTCCATATTAAACAAGT

>22523_22523_2_DHCR24-TADA2B_DHCR24_chr1_55330976_ENST00000535035_TADA2B_chr4_7055789_ENST00000310074_length(amino acids)=656AA_BP=326
LRCGGGQDFLGGWGAGVGEGLERNKNVMGAGEQNRQSAHCVQGICGYLEGDEEGEEGEVRSTQVREWKEQGSKTFMCTGRPGWLTVSLRV
GKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVL
ADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVM
TDEAEPSKLNSIGNYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQEDMAAHVGASRTPQEVMEHYVSMYIHGNLGKACI
PDTIPNRVTDHTCPSGGPLSPSLTTPLPPLDISVAEQQQLGYMPLRDDYEIEYDQDAETLISGLSVNYDDDDVEIELKRAHVDMYVRKLK
ERQRRKNIARDYNLVPAFLGKDKKEKEKALKRKITKEEKELRLKLRPLYQFMSCKEFDDLFENMHKEKMLRAKIRELQRYRRNGITKMEE
SAEYEAARHKREKRKENKNLAGSKRGKEDGKDSEFAAIENLPGFELLSDREKVLCSSLNLSPARYVTVKTIIIKDHLQKRQGIPSKSRLP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DHCR24-TADA2B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for DHCR24-TADA2B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for DHCR24-TADA2B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source