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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DHRS2-GSTM2 (FusionGDB2 ID:22574)

Fusion Gene Summary for DHRS2-GSTM2

check button Fusion gene summary
Fusion gene informationFusion gene name: DHRS2-GSTM2
Fusion gene ID: 22574
HgeneTgene
Gene symbol

DHRS2

GSTM2

Gene ID

10202

2946

Gene namedehydrogenase/reductase 2glutathione S-transferase mu 2
SynonymsHEP27|SDR25C1GST4|GSTM|GSTM2-2|GTHMUS
Cytomap

14q11.2

1p13.3

Type of geneprotein-codingprotein-coding
Descriptiondehydrogenase/reductase SDR family member 2, mitochondrialdehydrogenase/reductase (SDR family) member 2dehydrogenase/reductase member 2dicarbonyl reductase HEP27protein Dshort chain dehydrogenase/reductase family 25C member 1short-chain alcohol dehyglutathione S-transferase Mu 2GST class-mu 2GST, muscleS-(hydroxyalkyl)glutathione lyase M2epididymis secretory sperm binding proteinglutathione S-alkyltransferase M2glutathione S-aralkyltransferase M2glutathione S-aryltransferase M2glutathione S-
Modification date2020032920200313
UniProtAcc

Q13268

P28161

Ensembl transtripts involved in fusion geneENST00000250383, ENST00000344777, 
ENST00000553896, 		ENST00000369827, 
ENST00000369831, ENST00000442650, 
ENST00000460717, ENST00000241337, 
ENST00000369829, ENST00000414179, 
ENST00000464206, 
Fusion gene scores* DoF score4 X 4 X 2=324 X 3 X 3=36
# samples 54
** MAII scorelog2(5/32*10)=0.643856189774725
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DHRS2 [Title/Abstract] AND GSTM2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDHRS2(24105981)-GSTM2(110213909), # samples:16
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDHRS2

GO:0009636

response to toxic substance

16685466

HgeneDHRS2

GO:0034599

cellular response to oxidative stress

19443906

HgeneDHRS2

GO:0055114

oxidation-reduction process

16685466

TgeneGSTM2

GO:0006749

glutathione metabolic process

2034681|8373352|16549767

TgeneGSTM2

GO:0010880

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

17023043

TgeneGSTM2

GO:0018916

nitrobenzene metabolic process

2034681|8373352

TgeneGSTM2

GO:0042178

xenobiotic catabolic process

2034681|8373352|16549767

TgeneGSTM2

GO:0043651

linoleic acid metabolic process

16624487

TgeneGSTM2

GO:0060315

negative regulation of ryanodine-sensitive calcium-release channel activity

17023043|22406107

TgeneGSTM2

GO:0060316

positive regulation of ryanodine-sensitive calcium-release channel activity

17023043

TgeneGSTM2

GO:0070458

cellular detoxification of nitrogen compound

2034681|8373352

TgeneGSTM2

GO:0071313

cellular response to caffeine

22406107


check buttonFusion gene breakpoints across DHRS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GSTM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-DK-A1AD-01ADHRS2chr14

24105981

+GSTM2chr1

110213909

+
ChimerDB4BLCATCGA-DK-A3IT-01ADHRS2chr14

24105981

+GSTM2chr1

110213909

+
ChimerDB4BLCATCGA-DK-A3X1-01ADHRS2chr14

24105981

+GSTM2chr1

110213909

+
ChimerDB4BLCATCGA-FD-A62O-01ADHRS2chr14

24105981

+GSTM2chr1

110213909

+
ChimerDB4BLCATCGA-G2-A2EO-01ADHRS2chr14

24105981

+GSTM2chr1

110213909

+
ChimerDB4BLCATCGA-GC-A3RD-01ADHRS2chr14

24105981

+GSTM2chr1

110213909

+
ChimerDB4BLCATCGA-GV-A3JV-01ADHRS2chr14

24105981

+GSTM2chr1

110213909

+
ChimerDB4BLCATCGA-GV-A3QK-01BDHRS2chr14

24105981

+GSTM2chr1

110213909

+
ChimerDB4BLCATCGA-K4-A3WU-01BDHRS2chr14

24105981

+GSTM2chr1

110213909

+
ChimerDB4BLCATCGA-K4-A54R-01ADHRS2chr14

24105981

+GSTM2chr1

110213909

+
ChimerDB4BLCATCGA-UY-A78M-01ADHRS2chr14

24105981

+GSTM2chr1

110213909

+
ChimerDB4BLCATCGA-XF-A8HF-01ADHRS2chr14

24105981

+GSTM2chr1

110213909

+
ChimerDB4BLCATCGA-XF-A8HG-01ADHRS2chr14

24105981

+GSTM2chr1

110213909

+
ChimerDB4BLCATCGA-XF-A8HH-01ADHRS2chr14

24105981

+GSTM2chr1

110213909

+
ChimerDB4BLCATCGA-ZF-A9R3-01ADHRS2chr14

24105981

+GSTM2chr1

110213909

+
ChimerDB4BRCATCGA-A8-A09Q-01ADHRS2chr14

24105981

+GSTM2chr1

110213909

+


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Fusion Gene ORF analysis for DHRS2-GSTM2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000250383ENST00000369827DHRS2chr14

24105981

+GSTM2chr1

110213909

+
5UTR-3CDSENST00000250383ENST00000369831DHRS2chr14

24105981

+GSTM2chr1

110213909

+
5UTR-3CDSENST00000250383ENST00000442650DHRS2chr14

24105981

+GSTM2chr1

110213909

+
5UTR-3CDSENST00000250383ENST00000460717DHRS2chr14

24105981

+GSTM2chr1

110213909

+
5UTR-3CDSENST00000344777ENST00000369827DHRS2chr14

24105981

+GSTM2chr1

110213909

+
5UTR-3CDSENST00000344777ENST00000369831DHRS2chr14

24105981

+GSTM2chr1

110213909

+
5UTR-3CDSENST00000344777ENST00000442650DHRS2chr14

24105981

+GSTM2chr1

110213909

+
5UTR-3CDSENST00000344777ENST00000460717DHRS2chr14

24105981

+GSTM2chr1

110213909

+
5UTR-intronENST00000250383ENST00000241337DHRS2chr14

24105981

+GSTM2chr1

110213909

+
5UTR-intronENST00000250383ENST00000369829DHRS2chr14

24105981

+GSTM2chr1

110213909

+
5UTR-intronENST00000250383ENST00000414179DHRS2chr14

24105981

+GSTM2chr1

110213909

+
5UTR-intronENST00000250383ENST00000464206DHRS2chr14

24105981

+GSTM2chr1

110213909

+
5UTR-intronENST00000344777ENST00000241337DHRS2chr14

24105981

+GSTM2chr1

110213909

+
5UTR-intronENST00000344777ENST00000369829DHRS2chr14

24105981

+GSTM2chr1

110213909

+
5UTR-intronENST00000344777ENST00000414179DHRS2chr14

24105981

+GSTM2chr1

110213909

+
5UTR-intronENST00000344777ENST00000464206DHRS2chr14

24105981

+GSTM2chr1

110213909

+
intron-3CDSENST00000553896ENST00000369827DHRS2chr14

24105981

+GSTM2chr1

110213909

+
intron-3CDSENST00000553896ENST00000369831DHRS2chr14

24105981

+GSTM2chr1

110213909

+
intron-3CDSENST00000553896ENST00000442650DHRS2chr14

24105981

+GSTM2chr1

110213909

+
intron-3CDSENST00000553896ENST00000460717DHRS2chr14

24105981

+GSTM2chr1

110213909

+
intron-intronENST00000553896ENST00000241337DHRS2chr14

24105981

+GSTM2chr1

110213909

+
intron-intronENST00000553896ENST00000369829DHRS2chr14

24105981

+GSTM2chr1

110213909

+
intron-intronENST00000553896ENST00000414179DHRS2chr14

24105981

+GSTM2chr1

110213909

+
intron-intronENST00000553896ENST00000464206DHRS2chr14

24105981

+GSTM2chr1

110213909

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DHRS2-GSTM2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DHRS2chr1424105981+GSTM2chr1110213908+0.8566320.14336807
DHRS2chr1424105981+GSTM2chr1110213908+0.8566320.14336807
DHRS2chr1424105981+GSTM2chr1110213908+0.8566320.14336807
DHRS2chr1424105981+GSTM2chr1110213908+0.8566320.14336807

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DHRS2-GSTM2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:24105981/:110213909)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DHRS2

Q13268

GSTM2

P28161

FUNCTION: Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21. {ECO:0000269|PubMed:16685466, ECO:0000269|PubMed:20547751}.FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). {ECO:0000269|PubMed:16549767, ECO:0000269|PubMed:21046276}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DHRS2-GSTM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DHRS2-GSTM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DHRS2-GSTM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DHRS2-GSTM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource