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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADCY9-GLYR1 (FusionGDB2 ID:2258)

Fusion Gene Summary for ADCY9-GLYR1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADCY9-GLYR1
Fusion gene ID: 2258
HgeneTgene
Gene symbol

ADCY9

GLYR1

Gene ID

115

84656

Gene nameadenylate cyclase 9glyoxylate reductase 1 homolog
SynonymsAC9|ACIXBM045|HIBDL|N-PAC|NP60|hNDF
Cytomap

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionadenylate cyclase type 9ATP pyrophosphate-lyase 9adenylate cyclase type IXadenylyl cyclase 9type IX ATP pyrophosphate-lyaseputative oxidoreductase GLYR13-hydroxyisobutyrate dehydrogenase-like proteincytokine-like nuclear factor n-pacnuclear protein 60 kDanuclear protein 60kDanuclear protein NP60nuclear protein of 60 kDanucleosome-destabilizing factor
Modification date2020031320200313
UniProtAcc

O60503

Q49A26

Ensembl transtripts involved in fusion geneENST00000294016, ENST00000571889, 
ENST00000586901, ENST00000321919, 
ENST00000381983, ENST00000436648, 
ENST00000591451, 
Fusion gene scores* DoF score27 X 12 X 11=35649 X 6 X 7=378
# samples 2710
** MAII scorelog2(27/3564*10)=-3.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADCY9 [Title/Abstract] AND GLYR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADCY9(4038995)-GLYR1(4862249), # samples:3
GLYR1(4895075)-ADCY9(4057559), # samples:1
Anticipated loss of major functional domain due to fusion event.GLYR1-ADCY9 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
GLYR1-ADCY9 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
GLYR1-ADCY9 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
GLYR1-ADCY9 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GLYR1-ADCY9 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
GLYR1-ADCY9 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADCY9

GO:0006171

cAMP biosynthetic process

9628827|10987815

HgeneADCY9

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

9628827

TgeneGLYR1

GO:0035066

positive regulation of histone acetylation

29759984

TgeneGLYR1

GO:0045944

positive regulation of transcription by RNA polymerase II

29759984


check buttonFusion gene breakpoints across ADCY9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GLYR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A1RH-01AADCY9chr16

4038995

-GLYR1chr16

4862249

-


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Fusion Gene ORF analysis for ADCY9-GLYR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000294016ENST00000586901ADCY9chr16

4038995

-GLYR1chr16

4862249

-
In-frameENST00000294016ENST00000321919ADCY9chr16

4038995

-GLYR1chr16

4862249

-
In-frameENST00000294016ENST00000381983ADCY9chr16

4038995

-GLYR1chr16

4862249

-
In-frameENST00000294016ENST00000436648ADCY9chr16

4038995

-GLYR1chr16

4862249

-
In-frameENST00000294016ENST00000591451ADCY9chr16

4038995

-GLYR1chr16

4862249

-
intron-3CDSENST00000571889ENST00000321919ADCY9chr16

4038995

-GLYR1chr16

4862249

-
intron-3CDSENST00000571889ENST00000381983ADCY9chr16

4038995

-GLYR1chr16

4862249

-
intron-3CDSENST00000571889ENST00000436648ADCY9chr16

4038995

-GLYR1chr16

4862249

-
intron-3CDSENST00000571889ENST00000591451ADCY9chr16

4038995

-GLYR1chr16

4862249

-
intron-intronENST00000571889ENST00000586901ADCY9chr16

4038995

-GLYR1chr16

4862249

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000294016ADCY9chr164038995-ENST00000436648GLYR1chr164862249-542528495393391950
ENST00000294016ADCY9chr164038995-ENST00000321919GLYR1chr164862249-542528495393391950
ENST00000294016ADCY9chr164038995-ENST00000381983GLYR1chr164862249-542228495393391950
ENST00000294016ADCY9chr164038995-ENST00000591451GLYR1chr164862249-357928495393391950

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000294016ENST00000436648ADCY9chr164038995-GLYR1chr164862249-0.0012303970.9987696
ENST00000294016ENST00000321919ADCY9chr164038995-GLYR1chr164862249-0.0012303970.9987696
ENST00000294016ENST00000381983ADCY9chr164038995-GLYR1chr164862249-0.0012406040.9987594
ENST00000294016ENST00000591451ADCY9chr164038995-GLYR1chr164862249-0.0034730020.996527

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Fusion Genomic Features for ADCY9-GLYR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ADCY9-GLYR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:4038995/chr16:4862249)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADCY9

O60503

GLYR1

Q49A26

FUNCTION: Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}.FUNCTION: Nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:29759984). Facilitates Pol II transcription through nucleosomes (PubMed:29759984). Binds DNA (in vitro) (PubMed:29759984). Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3) (PubMed:20850016). Promotes KDM1B demethylase activity (PubMed:23260659). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664). Putative oxidoreductase (PubMed:23260659). {ECO:0000269|PubMed:16352664, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:29759984}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611394_5217701354.0DomainGuanylate cyclase 1
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611399_4047701354.0Nucleotide bindingATP
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611441_4437701354.0Nucleotide bindingATP
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611139_1417701354.0Topological domainExtracellular
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611163_1717701354.0Topological domainCytoplasmic
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611193_2157701354.0Topological domainExtracellular
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-6111_1177701354.0Topological domainCytoplasmic
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611236_2417701354.0Topological domainCytoplasmic
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611260_2807701354.0Topological domainExtracellular
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611118_1387701354.0TransmembraneHelical
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611142_1627701354.0TransmembraneHelical
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611172_1927701354.0TransmembraneHelical
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611216_2357701354.0TransmembraneHelical
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611242_2597701354.0TransmembraneHelical
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611281_3017701354.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-6111058_11987701354.0DomainGuanylate cyclase 2
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-6111185_11877701354.0Nucleotide bindingATP
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-6111192_11967701354.0Nucleotide bindingATP
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611302_7867701354.0Topological domainCytoplasmic
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611808_8187701354.0Topological domainExtracellular
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611840_8677701354.0Topological domainCytoplasmic
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611889_8917701354.0Topological domainExtracellular
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611913_9207701354.0Topological domainCytoplasmic
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611942_9757701354.0Topological domainExtracellular
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611997_13537701354.0Topological domainCytoplasmic
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611787_8077701354.0TransmembraneHelical
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611819_8397701354.0TransmembraneHelical
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611868_8887701354.0TransmembraneHelical
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611892_9127701354.0TransmembraneHelical
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611921_9417701354.0TransmembraneHelical
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611976_9967701354.0TransmembraneHelical
TgeneGLYR1chr16:4038995chr16:4862249ENST000003219191116168_180373554.0DNA bindingA.T hook
TgeneGLYR1chr16:4038995chr16:4862249ENST000003819831015168_180356537.0DNA bindingA.T hook
TgeneGLYR1chr16:4038995chr16:4862249ENST000004366481015168_180292473.0DNA bindingA.T hook
TgeneGLYR1chr16:4038995chr16:4862249ENST000005914511116168_180367548.0DNA bindingA.T hook
TgeneGLYR1chr16:4038995chr16:4862249ENST0000032191911168_66373554.0DomainPWWP
TgeneGLYR1chr16:4038995chr16:4862249ENST0000038198310158_66356537.0DomainPWWP
TgeneGLYR1chr16:4038995chr16:4862249ENST0000043664810158_66292473.0DomainPWWP
TgeneGLYR1chr16:4038995chr16:4862249ENST0000059145111168_66367548.0DomainPWWP
TgeneGLYR1chr16:4038995chr16:4862249ENST000003219191116271_285373554.0Nucleotide bindingNAD
TgeneGLYR1chr16:4038995chr16:4862249ENST000003819831015271_285356537.0Nucleotide bindingNAD
TgeneGLYR1chr16:4038995chr16:4862249ENST000004366481015271_285292473.0Nucleotide bindingNAD
TgeneGLYR1chr16:4038995chr16:4862249ENST000005914511116271_285367548.0Nucleotide bindingNAD


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Fusion Gene Sequence for ADCY9-GLYR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2258_2258_1_ADCY9-GLYR1_ADCY9_chr16_4038995_ENST00000294016_GLYR1_chr16_4862249_ENST00000321919_length(transcript)=5425nt_BP=2849nt
GCGGCCGCGGCGGGAGCGGCGGCGCACTCGGGGGGAAGCAGGCCCCACTAGACGGGCCGCGCCGACGGGCTCCGCGCACTCGCAGCCCGG
GGCGCCCCCACCCCCAGCGCCCGCCGCCGCGGGCAGGGCCGGCCCGGAGCGCGGGGGGCGGCCGGGGAGCGCGAGCCGGGGGCGCCCGCC
GAAGCTCGCTGCTCCGGGTCGGGGTCCGGGCCCGGGGCCGGCCGCGCGCCGCCTTTGACGCATCGGAGCGCGGCTCCTGCAGGATGGAGG
GCTCCGCGCCGCCAGCGGAGTTGTTTGTGCGCAGGCGGCTCGCGGGGCTGGGAGCGCTCAAGGTCTGAACTTCCCTCCGGAGCCGCAGCT
GGAGGAGGCGAGCGCGCGAGGAGGAGAAGCCGCGCGGCGCGGAGGCCACCCTCGGGGCGAGAGGCGCGGAAGGCGAGCGAGCAAAGCGGT
CCCGGAGCCACGGCGGCCACGCGGCGGGGACCCCCGGGCGTTCTAGGTACTGGTGACCCCGGCCGGGGCAGGCCCCGGGACTCGACAACA
TGGCTTCCCCACCCCACCAGCAGCTGCTGCATCACCACAGCACCGAGGTGAGCTGCGACTCCAGCGGGGACAGCAACAGCGTGCGCGTCA
AGATCAACCCCAAGCAGCTGTCCTCCAACAGCCACCCCAAGCACTGCAAATACAGCATCTCCTCTAGCTGCAGCAGCTCTGGGGACTCCG
GGGGCGTCCCCCGGCGAGTGGGCGGCGGAGGCCGGCTGCGCAGGCAGAAGAAGCTGCCCCAGCTGTTCGAGAGGGCCTCCAGCCGCTGGT
GGGACCCCAAGTTCGACTCGGTGAACCTGGAGGAGGCCTGCCTGGAGCGCTGCTTCCCGCAGACCCAGCGCCGGTTCCGGTATGCGCTCT
TCTACATCGGCTTCGCCTGCCTTCTGTGGAGCATCTATTTTGCGGTCCACATGAGATCCAGACTGATCGTCATGGTCGCCCCCGCGCTGT
GCTTCCTCCTGGTGTGTGTGGGCTTCTTTCTGTTTACCTTCACCAAGCTGTACGCCCGGCATTACGCGTGGACCTCGCTGGCTCTCACCC
TGCTGGTGTTCGCCCTGACCCTGGCTGCGCAGTTCCAGGTCTTGACGCCTGTCTCAGGACGCGGCGACAGCTCCAACCTTACGGCCACAG
CCCGGCCCACAGATACTTGCTTATCTCAAGTGGGGAGCTTCTCCATGTGCATCGAAGTGCTCTTTTTGCTCTATACCGTCATGCACTTAC
CTTTGTACCTGAGTTTGTGTCTGGGGGTGGCCTACTCTGTCCTTTTCGAGACCTTTGGCTACCATTTCCGGGATGAAGCCTGCTTCCCCT
CGCCCGGAGCCGGGGCCCTGCACTGGGAGCTGCTGAGCAGGGGGCTGCTCCACGGCTGCATCCACGCCATCGGGGTCCACCTGTTCGTCA
TGTCCCAGGTGAGGTCCAGGAGCACCTTCCTCAAGGTGGGGCAATCCATTATGCACGGGAAGGACCTGGAAGTGGAAAAAGCCCTCAAAG
AGAGGATGATTCATTCCGTGATGCCAAGAATCATAGCCGATGACTTAATGAAGCAGGGAGATGAGGAGAGTGAGAATTCTGTCAAGAGGC
ATGCCACCTCGAGCCCCAAGAACAGGAAGAAAAAGTCTTCCATCCAAAAAGCTCCTATAGCCTTCCGCCCTTTTAAGATGCAGCAGATCG
AAGAAGTCAGTATTTTATTTGCAGATATCGTGGGCTTCACCAAGATGAGTGCCAACAAGTCTGCCCACGCCCTGGTGGGTCTCCTGAACG
ATCTGTTCGGTCGCTTCGACCGCCTGTGTGAGGAGACCAAGTGTGAGAAAATCAGCACCCTGGGAGACTGTTACTACTGCGTGGCGGGCT
GTCCCGAGCCCCGGGCCGACCATGCCTACTGCTGCATCGAGATGGGCCTGGGCATGATCAAGGCCATCGAGCAGTTCTGCCAGGAGAAGA
AGGAGATGGTGAACATGAGAGTCGGGGTGCACACGGGCACCGTCCTTTGCGGCATCCTGGGCATGAGGAGGTTTAAATTTGACGTGTGGT
CCAACGATGTGAACCTGGCCAATCTCATGGAGCAGCTGGGAGTGGCCGGCAAAGTTCACATTTCTGAGGCCACCGCAAAATACTTAGATG
ACCGGTACGAAATGGAAGATGGGAAAGTTATTGAACGGCTGGGCCAGAGCGTGGTTGCTGACCAGTTGAAAGGTTTGAAGACATACCTGA
TATCGGGTCAGAGAGCCAAGGAGTCTCGCTGCAGCTGTGCAGAGGCCTTGCTTTCTGGCTTTGAGGTCATTGACGGCTCACAGGTGTCCT
CAGGCCCTAGGGGACAGGGGACAGCGTCATCAGGGAATGTCAGTGACTTGGCGCAGACTGTCAAAACCTTTGATAACCTTAAGACCTGCC
CTTCGTGCGGAATCACATTTGCTCCCAAATCTGAAGCCGGCGCCGAGGGAGGAGCACCTCAAAACGGCTGCCAAGACGAGCATAAAAACA
GCACCAAGGCTTCTGGAGGACCTAATCCCAAAACTCAGAACGGGCTCCTCAGCCCTCCCCAAGAGGAGAAGCTCACCAACAGTCAGACTT
CTCTGTGTGAGATCTTGCAGGAGAAGGGAAGGTGGGCAGGGGTGAGCCTGGACCAGTCGGCTCTCCTTCCGCTGAGGTTCAAGAACATCC
GGGAGAAAACGGACGCCCACTTTGTGGACGTTATCAAAGAAGACAGCCTGATGAAAGATTACTTTTTTAAGCCGCCCATTAATCAGTTCA
GCCTGAACTTCCTGGATCAGGAGCTGGAGCGATCCTACAGGACCAGCTATCAGGAAGAGGTGATTGTGTCCAGGGGGGGGCGCTTTCTGG
AAGCCCCCGTCTCAGGGAATCAGCAGCTGTCTAATGACGGGATGTTGGTGATCTTAGCGGCTGGAGACAGGGGCTTATATGAGGACTGCA
GCAGCTGCTTCCAGGCGATGGGGAAGACCTCCTTCTTCCTAGGTGAAGTGGGCAATGCAGCCAAGATGATGCTGATCGTGAACATGGTCC
AAGGGAGCTTCATGGCCACTATTGCCGAGGGGCTGACCCTGGCCCACGTGACAGGCCAGTCCCAGCAGACACTCTTGGACATCCTCAATC
AGGGACAGTTGGCCAGCATCTTCCTGGACCAGAAGTGCCAAAATATCCTGCAAGGAAACTTTAAGCCTGATTTCTACCTGAAATACATTC
AGAAGGATCTCCGCTTAGCCATTGCGCTGGGTGATGCGGTCAACCATCCGACTCCCATGGCAGCTGCAGCAAATGAGGTGTACAAAAGAG
CCAAGGCGCTGGACCAGTCTGACAACGATATGTCCGCCGTGTACCGAGCCTACATACACTAAGCTGTCGACACCCCGCCCTCACCCCTCC
AATCCCCCCTCTGACCCCCTCTTCCTCACATGGGGTCGGGGGCCTGGGAGTTCATTCTGGACCAGCCCACCTATCTCCATTTCCTTTTAT
ACAGACTTTGAGACTTGCCATCAGCACAGCACACAGCAGCACCCTTCCCCTGAGGCCGGTGGGGAGGGGACAAGTGTCAGCAGGATTGGC
GTGTGGGAAAGCTCTTGAGCTGGGCACTGGCCCCCCGGACGAGGTGGCTGTGTGTTCACACACACACACACACACACACACACACACACA
CACAGGCTCTCGCCCCAGGATAGAAGCTGCCCAGAAACTGCTGCCTGGCTTTTTTTCTTCCGAGCTTGTCTTATCTCAAACCCCTTCCAG
TCAAGGAACTAGAATCAGCAACGAGAGTTGGAAGCCTTCCCACAGCTTCCCCCAGAGCGAAGAGGCTGTAGTCATGTCCCCATCCCCCAC
TGGATTCCCTACAAGGAGAGGCCTTGGGCCCAGATGAGCCAGTACAGACTCCAGACAGAGGGGCCCTTGGGGCCCTCCAACCTCAGGTGA
TGAGCTGAGAAAGATGTTCACGTCTAAGCGTCCAGTGTGCACCCAGCGCTCCATAGACGCCTTTGTGAACTGAAAAGAGACTGGCAGAGT
CCCGAGAAGATGGGGCCCTGGCTTTCCAGGGAGTGCAGCAAGCAGCCGGCCTGCAGGTGAGCATGGAGGCCCGGCCCTCACCGCCTCGAA
GCCATGCCCCAGATGCCACTGCCACAGCGGGCGCTCGCTCCTCCCTAGGCTGTTTTAGTATTTGGATTTGCATTCCATCCCTTGGGAGGG
AGTCCTCAGGGCCACTAGTGATGAGCCAAGAGGAGTGGGGGTTGGGGGCGCTCCTTTCTGTTTCCGTTAGGCCACAGACTCTTCACCTGG
CTCTGAAGAGCCACTCTTACCTCGGTCCCCTCCCAGTGGTCCCACCTTCTCCACCCTGCCCTGCCAAGTCCCCTGCATGCCCACCGCTCT
CCATCCTCCCTCCTCTCCCTCTTCCTCCCGTGGAGACAGTATTTCTTTCTGTCTGTCCCTTTGGCCCAGACCCAGCCTGACCAACGATGA
GCATTTCTTAGGCTCAGCTCTTGATACGGAAACGAGTGTCTTCACTCCAGCCAGCATCATGGTCTTCGGTGCTTCCCGGGCCCGGGGTCT
GTCGGGAGGGAAGAGAACTGGGCCTGACCTACCTGAACTGACTGGCCCTCCGAGGTGGGTCTGGGACATCCTAGAGGCCCTACATTTGTC
CTTGGATAGGGGACCGGGGGGGGCTTGGAATGTTGCAAAAAAAAAAGTTACCCAAGGGATGTCAGTTTTTTATCCCTCTGCATGGGTTGG
ATTTTCCAAAATCATAATTTGCAGAAGGAAGGCCAGCATTTACGATGCAATATGTAATTATATATAGGGTGGCCACACTAGGGCGGGGTC
CTTCCCCCCTCACAGCTTTGGCCCCTTTCAGAGATTAGAAACTGGGTTAGAGGATTGCAGAAGACGAGTGGGGGGAGGGCAGGGAAGATG
CCTGTCGGGTTTTTAGCACAGTTCATTTCACTGGGATTTTGAAGCATTTCTGTCTGAACACAAAGCCTGTTCTAGTCCTGGCGGAACACA
CTGGGGGTGGGGGCGGGGGAAGATGCGGTAATGAAACCGGTTAGTCAATTTTGTCTTAATATTGTTGACAATTCTGTAAAGTTCCTTTTT
ATGAATATTTCTGTTTAAGCTATTTCACCTTTCTTTTGAAATCCTTCCCTTTTAAGGAGAAAATGTGACACTTGTGAAAAAGCTTGTAAG
AAAGCCCCTCCCTTTTTTCTTTAAACCTTTAAATGACAAATCTAGGTAATTAAGGTTGTGAATTTTTATTTTTGCTTTGTTTTTAATGAA
CATTTGTCTTTCAGAATAGGATTGTGTGATAATGTTTAAATGGCAAAAACAAAACATGATTTTGTGCAATTAACAAAGCTACTGCAAGAA

>2258_2258_1_ADCY9-GLYR1_ADCY9_chr16_4038995_ENST00000294016_GLYR1_chr16_4862249_ENST00000321919_length(amino acids)=950AA_BP=770
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRW
WDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFP
SPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG
CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
DRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTC
PSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNI
REKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDC
SSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAHVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYI

--------------------------------------------------------------
>2258_2258_2_ADCY9-GLYR1_ADCY9_chr16_4038995_ENST00000294016_GLYR1_chr16_4862249_ENST00000381983_length(transcript)=5422nt_BP=2849nt
GCGGCCGCGGCGGGAGCGGCGGCGCACTCGGGGGGAAGCAGGCCCCACTAGACGGGCCGCGCCGACGGGCTCCGCGCACTCGCAGCCCGG
GGCGCCCCCACCCCCAGCGCCCGCCGCCGCGGGCAGGGCCGGCCCGGAGCGCGGGGGGCGGCCGGGGAGCGCGAGCCGGGGGCGCCCGCC
GAAGCTCGCTGCTCCGGGTCGGGGTCCGGGCCCGGGGCCGGCCGCGCGCCGCCTTTGACGCATCGGAGCGCGGCTCCTGCAGGATGGAGG
GCTCCGCGCCGCCAGCGGAGTTGTTTGTGCGCAGGCGGCTCGCGGGGCTGGGAGCGCTCAAGGTCTGAACTTCCCTCCGGAGCCGCAGCT
GGAGGAGGCGAGCGCGCGAGGAGGAGAAGCCGCGCGGCGCGGAGGCCACCCTCGGGGCGAGAGGCGCGGAAGGCGAGCGAGCAAAGCGGT
CCCGGAGCCACGGCGGCCACGCGGCGGGGACCCCCGGGCGTTCTAGGTACTGGTGACCCCGGCCGGGGCAGGCCCCGGGACTCGACAACA
TGGCTTCCCCACCCCACCAGCAGCTGCTGCATCACCACAGCACCGAGGTGAGCTGCGACTCCAGCGGGGACAGCAACAGCGTGCGCGTCA
AGATCAACCCCAAGCAGCTGTCCTCCAACAGCCACCCCAAGCACTGCAAATACAGCATCTCCTCTAGCTGCAGCAGCTCTGGGGACTCCG
GGGGCGTCCCCCGGCGAGTGGGCGGCGGAGGCCGGCTGCGCAGGCAGAAGAAGCTGCCCCAGCTGTTCGAGAGGGCCTCCAGCCGCTGGT
GGGACCCCAAGTTCGACTCGGTGAACCTGGAGGAGGCCTGCCTGGAGCGCTGCTTCCCGCAGACCCAGCGCCGGTTCCGGTATGCGCTCT
TCTACATCGGCTTCGCCTGCCTTCTGTGGAGCATCTATTTTGCGGTCCACATGAGATCCAGACTGATCGTCATGGTCGCCCCCGCGCTGT
GCTTCCTCCTGGTGTGTGTGGGCTTCTTTCTGTTTACCTTCACCAAGCTGTACGCCCGGCATTACGCGTGGACCTCGCTGGCTCTCACCC
TGCTGGTGTTCGCCCTGACCCTGGCTGCGCAGTTCCAGGTCTTGACGCCTGTCTCAGGACGCGGCGACAGCTCCAACCTTACGGCCACAG
CCCGGCCCACAGATACTTGCTTATCTCAAGTGGGGAGCTTCTCCATGTGCATCGAAGTGCTCTTTTTGCTCTATACCGTCATGCACTTAC
CTTTGTACCTGAGTTTGTGTCTGGGGGTGGCCTACTCTGTCCTTTTCGAGACCTTTGGCTACCATTTCCGGGATGAAGCCTGCTTCCCCT
CGCCCGGAGCCGGGGCCCTGCACTGGGAGCTGCTGAGCAGGGGGCTGCTCCACGGCTGCATCCACGCCATCGGGGTCCACCTGTTCGTCA
TGTCCCAGGTGAGGTCCAGGAGCACCTTCCTCAAGGTGGGGCAATCCATTATGCACGGGAAGGACCTGGAAGTGGAAAAAGCCCTCAAAG
AGAGGATGATTCATTCCGTGATGCCAAGAATCATAGCCGATGACTTAATGAAGCAGGGAGATGAGGAGAGTGAGAATTCTGTCAAGAGGC
ATGCCACCTCGAGCCCCAAGAACAGGAAGAAAAAGTCTTCCATCCAAAAAGCTCCTATAGCCTTCCGCCCTTTTAAGATGCAGCAGATCG
AAGAAGTCAGTATTTTATTTGCAGATATCGTGGGCTTCACCAAGATGAGTGCCAACAAGTCTGCCCACGCCCTGGTGGGTCTCCTGAACG
ATCTGTTCGGTCGCTTCGACCGCCTGTGTGAGGAGACCAAGTGTGAGAAAATCAGCACCCTGGGAGACTGTTACTACTGCGTGGCGGGCT
GTCCCGAGCCCCGGGCCGACCATGCCTACTGCTGCATCGAGATGGGCCTGGGCATGATCAAGGCCATCGAGCAGTTCTGCCAGGAGAAGA
AGGAGATGGTGAACATGAGAGTCGGGGTGCACACGGGCACCGTCCTTTGCGGCATCCTGGGCATGAGGAGGTTTAAATTTGACGTGTGGT
CCAACGATGTGAACCTGGCCAATCTCATGGAGCAGCTGGGAGTGGCCGGCAAAGTTCACATTTCTGAGGCCACCGCAAAATACTTAGATG
ACCGGTACGAAATGGAAGATGGGAAAGTTATTGAACGGCTGGGCCAGAGCGTGGTTGCTGACCAGTTGAAAGGTTTGAAGACATACCTGA
TATCGGGTCAGAGAGCCAAGGAGTCTCGCTGCAGCTGTGCAGAGGCCTTGCTTTCTGGCTTTGAGGTCATTGACGGCTCACAGGTGTCCT
CAGGCCCTAGGGGACAGGGGACAGCGTCATCAGGGAATGTCAGTGACTTGGCGCAGACTGTCAAAACCTTTGATAACCTTAAGACCTGCC
CTTCGTGCGGAATCACATTTGCTCCCAAATCTGAAGCCGGCGCCGAGGGAGGAGCACCTCAAAACGGCTGCCAAGACGAGCATAAAAACA
GCACCAAGGCTTCTGGAGGACCTAATCCCAAAACTCAGAACGGGCTCCTCAGCCCTCCCCAAGAGGAGAAGCTCACCAACAGTCAGACTT
CTCTGTGTGAGATCTTGCAGGAGAAGGGAAGGTGGGCAGGGGTGAGCCTGGACCAGTCGGCTCTCCTTCCGCTGAGGTTCAAGAACATCC
GGGAGAAAACGGACGCCCACTTTGTGGACGTTATCAAAGAAGACAGCCTGATGAAAGATTACTTTTTTAAGCCGCCCATTAATCAGTTCA
GCCTGAACTTCCTGGATCAGGAGCTGGAGCGATCCTACAGGACCAGCTATCAGGAAGAGGTGATTGTGTCCAGGGGGGGGCGCTTTCTGG
AAGCCCCCGTCTCAGGGAATCAGCAGCTGTCTAATGACGGGATGTTGGTGATCTTAGCGGCTGGAGACAGGGGCTTATATGAGGACTGCA
GCAGCTGCTTCCAGGCGATGGGGAAGACCTCCTTCTTCCTAGGTGAAGTGGGCAATGCAGCCAAGATGATGCTGATCGTGAACATGGTCC
AAGGGAGCTTCATGGCCACTATTGCCGAGGGGCTGACCCTGGCCCACGTGACAGGCCAGTCCCAGCAGACACTCTTGGACATCCTCAATC
AGGGACAGTTGGCCAGCATCTTCCTGGACCAGAAGTGCCAAAATATCCTGCAAGGAAACTTTAAGCCTGATTTCTACCTGAAATACATTC
AGAAGGATCTCCGCTTAGCCATTGCGCTGGGTGATGCGGTCAACCATCCGACTCCCATGGCAGCTGCAGCAAATGAGGTGTACAAAAGAG
CCAAGGCGCTGGACCAGTCTGACAACGATATGTCCGCCGTGTACCGAGCCTACATACACTAAGCTGTCGACACCCCGCCCTCACCCCTCC
AATCCCCCCTCTGACCCCCTCTTCCTCACATGGGGTCGGGGGCCTGGGAGTTCATTCTGGACCAGCCCACCTATCTCCATTTCCTTTTAT
ACAGACTTTGAGACTTGCCATCAGCACAGCACACAGCAGCACCCTTCCCCTGAGGCCGGTGGGGAGGGGACAAGTGTCAGCAGGATTGGC
GTGTGGGAAAGCTCTTGAGCTGGGCACTGGCCCCCCGGACGAGGTGGCTGTGTGTTCACACACACACACACACACACACACACACACACA
CACAGGCTCTCGCCCCAGGATAGAAGCTGCCCAGAAACTGCTGCCTGGCTTTTTTTCTTCCGAGCTTGTCTTATCTCAAACCCCTTCCAG
TCAAGGAACTAGAATCAGCAACGAGAGTTGGAAGCCTTCCCACAGCTTCCCCCAGAGCGAAGAGGCTGTAGTCATGTCCCCATCCCCCAC
TGGATTCCCTACAAGGAGAGGCCTTGGGCCCAGATGAGCCAGTACAGACTCCAGACAGAGGGGCCCTTGGGGCCCTCCAACCTCAGGTGA
TGAGCTGAGAAAGATGTTCACGTCTAAGCGTCCAGTGTGCACCCAGCGCTCCATAGACGCCTTTGTGAACTGAAAAGAGACTGGCAGAGT
CCCGAGAAGATGGGGCCCTGGCTTTCCAGGGAGTGCAGCAAGCAGCCGGCCTGCAGGTGAGCATGGAGGCCCGGCCCTCACCGCCTCGAA
GCCATGCCCCAGATGCCACTGCCACAGCGGGCGCTCGCTCCTCCCTAGGCTGTTTTAGTATTTGGATTTGCATTCCATCCCTTGGGAGGG
AGTCCTCAGGGCCACTAGTGATGAGCCAAGAGGAGTGGGGGTTGGGGGCGCTCCTTTCTGTTTCCGTTAGGCCACAGACTCTTCACCTGG
CTCTGAAGAGCCACTCTTACCTCGGTCCCCTCCCAGTGGTCCCACCTTCTCCACCCTGCCCTGCCAAGTCCCCTGCATGCCCACCGCTCT
CCATCCTCCCTCCTCTCCCTCTTCCTCCCGTGGAGACAGTATTTCTTTCTGTCTGTCCCTTTGGCCCAGACCCAGCCTGACCAACGATGA
GCATTTCTTAGGCTCAGCTCTTGATACGGAAACGAGTGTCTTCACTCCAGCCAGCATCATGGTCTTCGGTGCTTCCCGGGCCCGGGGTCT
GTCGGGAGGGAAGAGAACTGGGCCTGACCTACCTGAACTGACTGGCCCTCCGAGGTGGGTCTGGGACATCCTAGAGGCCCTACATTTGTC
CTTGGATAGGGGACCGGGGGGGGCTTGGAATGTTGCAAAAAAAAAAGTTACCCAAGGGATGTCAGTTTTTTATCCCTCTGCATGGGTTGG
ATTTTCCAAAATCATAATTTGCAGAAGGAAGGCCAGCATTTACGATGCAATATGTAATTATATATAGGGTGGCCACACTAGGGCGGGGTC
CTTCCCCCCTCACAGCTTTGGCCCCTTTCAGAGATTAGAAACTGGGTTAGAGGATTGCAGAAGACGAGTGGGGGGAGGGCAGGGAAGATG
CCTGTCGGGTTTTTAGCACAGTTCATTTCACTGGGATTTTGAAGCATTTCTGTCTGAACACAAAGCCTGTTCTAGTCCTGGCGGAACACA
CTGGGGGTGGGGGCGGGGGAAGATGCGGTAATGAAACCGGTTAGTCAATTTTGTCTTAATATTGTTGACAATTCTGTAAAGTTCCTTTTT
ATGAATATTTCTGTTTAAGCTATTTCACCTTTCTTTTGAAATCCTTCCCTTTTAAGGAGAAAATGTGACACTTGTGAAAAAGCTTGTAAG
AAAGCCCCTCCCTTTTTTCTTTAAACCTTTAAATGACAAATCTAGGTAATTAAGGTTGTGAATTTTTATTTTTGCTTTGTTTTTAATGAA
CATTTGTCTTTCAGAATAGGATTGTGTGATAATGTTTAAATGGCAAAAACAAAACATGATTTTGTGCAATTAACAAAGCTACTGCAAGAA

>2258_2258_2_ADCY9-GLYR1_ADCY9_chr16_4038995_ENST00000294016_GLYR1_chr16_4862249_ENST00000381983_length(amino acids)=950AA_BP=770
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRW
WDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFP
SPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG
CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
DRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTC
PSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNI
REKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDC
SSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAHVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYI

--------------------------------------------------------------
>2258_2258_3_ADCY9-GLYR1_ADCY9_chr16_4038995_ENST00000294016_GLYR1_chr16_4862249_ENST00000436648_length(transcript)=5425nt_BP=2849nt
GCGGCCGCGGCGGGAGCGGCGGCGCACTCGGGGGGAAGCAGGCCCCACTAGACGGGCCGCGCCGACGGGCTCCGCGCACTCGCAGCCCGG
GGCGCCCCCACCCCCAGCGCCCGCCGCCGCGGGCAGGGCCGGCCCGGAGCGCGGGGGGCGGCCGGGGAGCGCGAGCCGGGGGCGCCCGCC
GAAGCTCGCTGCTCCGGGTCGGGGTCCGGGCCCGGGGCCGGCCGCGCGCCGCCTTTGACGCATCGGAGCGCGGCTCCTGCAGGATGGAGG
GCTCCGCGCCGCCAGCGGAGTTGTTTGTGCGCAGGCGGCTCGCGGGGCTGGGAGCGCTCAAGGTCTGAACTTCCCTCCGGAGCCGCAGCT
GGAGGAGGCGAGCGCGCGAGGAGGAGAAGCCGCGCGGCGCGGAGGCCACCCTCGGGGCGAGAGGCGCGGAAGGCGAGCGAGCAAAGCGGT
CCCGGAGCCACGGCGGCCACGCGGCGGGGACCCCCGGGCGTTCTAGGTACTGGTGACCCCGGCCGGGGCAGGCCCCGGGACTCGACAACA
TGGCTTCCCCACCCCACCAGCAGCTGCTGCATCACCACAGCACCGAGGTGAGCTGCGACTCCAGCGGGGACAGCAACAGCGTGCGCGTCA
AGATCAACCCCAAGCAGCTGTCCTCCAACAGCCACCCCAAGCACTGCAAATACAGCATCTCCTCTAGCTGCAGCAGCTCTGGGGACTCCG
GGGGCGTCCCCCGGCGAGTGGGCGGCGGAGGCCGGCTGCGCAGGCAGAAGAAGCTGCCCCAGCTGTTCGAGAGGGCCTCCAGCCGCTGGT
GGGACCCCAAGTTCGACTCGGTGAACCTGGAGGAGGCCTGCCTGGAGCGCTGCTTCCCGCAGACCCAGCGCCGGTTCCGGTATGCGCTCT
TCTACATCGGCTTCGCCTGCCTTCTGTGGAGCATCTATTTTGCGGTCCACATGAGATCCAGACTGATCGTCATGGTCGCCCCCGCGCTGT
GCTTCCTCCTGGTGTGTGTGGGCTTCTTTCTGTTTACCTTCACCAAGCTGTACGCCCGGCATTACGCGTGGACCTCGCTGGCTCTCACCC
TGCTGGTGTTCGCCCTGACCCTGGCTGCGCAGTTCCAGGTCTTGACGCCTGTCTCAGGACGCGGCGACAGCTCCAACCTTACGGCCACAG
CCCGGCCCACAGATACTTGCTTATCTCAAGTGGGGAGCTTCTCCATGTGCATCGAAGTGCTCTTTTTGCTCTATACCGTCATGCACTTAC
CTTTGTACCTGAGTTTGTGTCTGGGGGTGGCCTACTCTGTCCTTTTCGAGACCTTTGGCTACCATTTCCGGGATGAAGCCTGCTTCCCCT
CGCCCGGAGCCGGGGCCCTGCACTGGGAGCTGCTGAGCAGGGGGCTGCTCCACGGCTGCATCCACGCCATCGGGGTCCACCTGTTCGTCA
TGTCCCAGGTGAGGTCCAGGAGCACCTTCCTCAAGGTGGGGCAATCCATTATGCACGGGAAGGACCTGGAAGTGGAAAAAGCCCTCAAAG
AGAGGATGATTCATTCCGTGATGCCAAGAATCATAGCCGATGACTTAATGAAGCAGGGAGATGAGGAGAGTGAGAATTCTGTCAAGAGGC
ATGCCACCTCGAGCCCCAAGAACAGGAAGAAAAAGTCTTCCATCCAAAAAGCTCCTATAGCCTTCCGCCCTTTTAAGATGCAGCAGATCG
AAGAAGTCAGTATTTTATTTGCAGATATCGTGGGCTTCACCAAGATGAGTGCCAACAAGTCTGCCCACGCCCTGGTGGGTCTCCTGAACG
ATCTGTTCGGTCGCTTCGACCGCCTGTGTGAGGAGACCAAGTGTGAGAAAATCAGCACCCTGGGAGACTGTTACTACTGCGTGGCGGGCT
GTCCCGAGCCCCGGGCCGACCATGCCTACTGCTGCATCGAGATGGGCCTGGGCATGATCAAGGCCATCGAGCAGTTCTGCCAGGAGAAGA
AGGAGATGGTGAACATGAGAGTCGGGGTGCACACGGGCACCGTCCTTTGCGGCATCCTGGGCATGAGGAGGTTTAAATTTGACGTGTGGT
CCAACGATGTGAACCTGGCCAATCTCATGGAGCAGCTGGGAGTGGCCGGCAAAGTTCACATTTCTGAGGCCACCGCAAAATACTTAGATG
ACCGGTACGAAATGGAAGATGGGAAAGTTATTGAACGGCTGGGCCAGAGCGTGGTTGCTGACCAGTTGAAAGGTTTGAAGACATACCTGA
TATCGGGTCAGAGAGCCAAGGAGTCTCGCTGCAGCTGTGCAGAGGCCTTGCTTTCTGGCTTTGAGGTCATTGACGGCTCACAGGTGTCCT
CAGGCCCTAGGGGACAGGGGACAGCGTCATCAGGGAATGTCAGTGACTTGGCGCAGACTGTCAAAACCTTTGATAACCTTAAGACCTGCC
CTTCGTGCGGAATCACATTTGCTCCCAAATCTGAAGCCGGCGCCGAGGGAGGAGCACCTCAAAACGGCTGCCAAGACGAGCATAAAAACA
GCACCAAGGCTTCTGGAGGACCTAATCCCAAAACTCAGAACGGGCTCCTCAGCCCTCCCCAAGAGGAGAAGCTCACCAACAGTCAGACTT
CTCTGTGTGAGATCTTGCAGGAGAAGGGAAGGTGGGCAGGGGTGAGCCTGGACCAGTCGGCTCTCCTTCCGCTGAGGTTCAAGAACATCC
GGGAGAAAACGGACGCCCACTTTGTGGACGTTATCAAAGAAGACAGCCTGATGAAAGATTACTTTTTTAAGCCGCCCATTAATCAGTTCA
GCCTGAACTTCCTGGATCAGGAGCTGGAGCGATCCTACAGGACCAGCTATCAGGAAGAGGTGATTGTGTCCAGGGGGGGGCGCTTTCTGG
AAGCCCCCGTCTCAGGGAATCAGCAGCTGTCTAATGACGGGATGTTGGTGATCTTAGCGGCTGGAGACAGGGGCTTATATGAGGACTGCA
GCAGCTGCTTCCAGGCGATGGGGAAGACCTCCTTCTTCCTAGGTGAAGTGGGCAATGCAGCCAAGATGATGCTGATCGTGAACATGGTCC
AAGGGAGCTTCATGGCCACTATTGCCGAGGGGCTGACCCTGGCCCACGTGACAGGCCAGTCCCAGCAGACACTCTTGGACATCCTCAATC
AGGGACAGTTGGCCAGCATCTTCCTGGACCAGAAGTGCCAAAATATCCTGCAAGGAAACTTTAAGCCTGATTTCTACCTGAAATACATTC
AGAAGGATCTCCGCTTAGCCATTGCGCTGGGTGATGCGGTCAACCATCCGACTCCCATGGCAGCTGCAGCAAATGAGGTGTACAAAAGAG
CCAAGGCGCTGGACCAGTCTGACAACGATATGTCCGCCGTGTACCGAGCCTACATACACTAAGCTGTCGACACCCCGCCCTCACCCCTCC
AATCCCCCCTCTGACCCCCTCTTCCTCACATGGGGTCGGGGGCCTGGGAGTTCATTCTGGACCAGCCCACCTATCTCCATTTCCTTTTAT
ACAGACTTTGAGACTTGCCATCAGCACAGCACACAGCAGCACCCTTCCCCTGAGGCCGGTGGGGAGGGGACAAGTGTCAGCAGGATTGGC
GTGTGGGAAAGCTCTTGAGCTGGGCACTGGCCCCCCGGACGAGGTGGCTGTGTGTTCACACACACACACACACACACACACACACACACA
CACAGGCTCTCGCCCCAGGATAGAAGCTGCCCAGAAACTGCTGCCTGGCTTTTTTTCTTCCGAGCTTGTCTTATCTCAAACCCCTTCCAG
TCAAGGAACTAGAATCAGCAACGAGAGTTGGAAGCCTTCCCACAGCTTCCCCCAGAGCGAAGAGGCTGTAGTCATGTCCCCATCCCCCAC
TGGATTCCCTACAAGGAGAGGCCTTGGGCCCAGATGAGCCAGTACAGACTCCAGACAGAGGGGCCCTTGGGGCCCTCCAACCTCAGGTGA
TGAGCTGAGAAAGATGTTCACGTCTAAGCGTCCAGTGTGCACCCAGCGCTCCATAGACGCCTTTGTGAACTGAAAAGAGACTGGCAGAGT
CCCGAGAAGATGGGGCCCTGGCTTTCCAGGGAGTGCAGCAAGCAGCCGGCCTGCAGGTGAGCATGGAGGCCCGGCCCTCACCGCCTCGAA
GCCATGCCCCAGATGCCACTGCCACAGCGGGCGCTCGCTCCTCCCTAGGCTGTTTTAGTATTTGGATTTGCATTCCATCCCTTGGGAGGG
AGTCCTCAGGGCCACTAGTGATGAGCCAAGAGGAGTGGGGGTTGGGGGCGCTCCTTTCTGTTTCCGTTAGGCCACAGACTCTTCACCTGG
CTCTGAAGAGCCACTCTTACCTCGGTCCCCTCCCAGTGGTCCCACCTTCTCCACCCTGCCCTGCCAAGTCCCCTGCATGCCCACCGCTCT
CCATCCTCCCTCCTCTCCCTCTTCCTCCCGTGGAGACAGTATTTCTTTCTGTCTGTCCCTTTGGCCCAGACCCAGCCTGACCAACGATGA
GCATTTCTTAGGCTCAGCTCTTGATACGGAAACGAGTGTCTTCACTCCAGCCAGCATCATGGTCTTCGGTGCTTCCCGGGCCCGGGGTCT
GTCGGGAGGGAAGAGAACTGGGCCTGACCTACCTGAACTGACTGGCCCTCCGAGGTGGGTCTGGGACATCCTAGAGGCCCTACATTTGTC
CTTGGATAGGGGACCGGGGGGGGCTTGGAATGTTGCAAAAAAAAAAGTTACCCAAGGGATGTCAGTTTTTTATCCCTCTGCATGGGTTGG
ATTTTCCAAAATCATAATTTGCAGAAGGAAGGCCAGCATTTACGATGCAATATGTAATTATATATAGGGTGGCCACACTAGGGCGGGGTC
CTTCCCCCCTCACAGCTTTGGCCCCTTTCAGAGATTAGAAACTGGGTTAGAGGATTGCAGAAGACGAGTGGGGGGAGGGCAGGGAAGATG
CCTGTCGGGTTTTTAGCACAGTTCATTTCACTGGGATTTTGAAGCATTTCTGTCTGAACACAAAGCCTGTTCTAGTCCTGGCGGAACACA
CTGGGGGTGGGGGCGGGGGAAGATGCGGTAATGAAACCGGTTAGTCAATTTTGTCTTAATATTGTTGACAATTCTGTAAAGTTCCTTTTT
ATGAATATTTCTGTTTAAGCTATTTCACCTTTCTTTTGAAATCCTTCCCTTTTAAGGAGAAAATGTGACACTTGTGAAAAAGCTTGTAAG
AAAGCCCCTCCCTTTTTTCTTTAAACCTTTAAATGACAAATCTAGGTAATTAAGGTTGTGAATTTTTATTTTTGCTTTGTTTTTAATGAA
CATTTGTCTTTCAGAATAGGATTGTGTGATAATGTTTAAATGGCAAAAACAAAACATGATTTTGTGCAATTAACAAAGCTACTGCAAGAA

>2258_2258_3_ADCY9-GLYR1_ADCY9_chr16_4038995_ENST00000294016_GLYR1_chr16_4862249_ENST00000436648_length(amino acids)=950AA_BP=770
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRW
WDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFP
SPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG
CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
DRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTC
PSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNI
REKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDC
SSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAHVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYI

--------------------------------------------------------------
>2258_2258_4_ADCY9-GLYR1_ADCY9_chr16_4038995_ENST00000294016_GLYR1_chr16_4862249_ENST00000591451_length(transcript)=3579nt_BP=2849nt
GCGGCCGCGGCGGGAGCGGCGGCGCACTCGGGGGGAAGCAGGCCCCACTAGACGGGCCGCGCCGACGGGCTCCGCGCACTCGCAGCCCGG
GGCGCCCCCACCCCCAGCGCCCGCCGCCGCGGGCAGGGCCGGCCCGGAGCGCGGGGGGCGGCCGGGGAGCGCGAGCCGGGGGCGCCCGCC
GAAGCTCGCTGCTCCGGGTCGGGGTCCGGGCCCGGGGCCGGCCGCGCGCCGCCTTTGACGCATCGGAGCGCGGCTCCTGCAGGATGGAGG
GCTCCGCGCCGCCAGCGGAGTTGTTTGTGCGCAGGCGGCTCGCGGGGCTGGGAGCGCTCAAGGTCTGAACTTCCCTCCGGAGCCGCAGCT
GGAGGAGGCGAGCGCGCGAGGAGGAGAAGCCGCGCGGCGCGGAGGCCACCCTCGGGGCGAGAGGCGCGGAAGGCGAGCGAGCAAAGCGGT
CCCGGAGCCACGGCGGCCACGCGGCGGGGACCCCCGGGCGTTCTAGGTACTGGTGACCCCGGCCGGGGCAGGCCCCGGGACTCGACAACA
TGGCTTCCCCACCCCACCAGCAGCTGCTGCATCACCACAGCACCGAGGTGAGCTGCGACTCCAGCGGGGACAGCAACAGCGTGCGCGTCA
AGATCAACCCCAAGCAGCTGTCCTCCAACAGCCACCCCAAGCACTGCAAATACAGCATCTCCTCTAGCTGCAGCAGCTCTGGGGACTCCG
GGGGCGTCCCCCGGCGAGTGGGCGGCGGAGGCCGGCTGCGCAGGCAGAAGAAGCTGCCCCAGCTGTTCGAGAGGGCCTCCAGCCGCTGGT
GGGACCCCAAGTTCGACTCGGTGAACCTGGAGGAGGCCTGCCTGGAGCGCTGCTTCCCGCAGACCCAGCGCCGGTTCCGGTATGCGCTCT
TCTACATCGGCTTCGCCTGCCTTCTGTGGAGCATCTATTTTGCGGTCCACATGAGATCCAGACTGATCGTCATGGTCGCCCCCGCGCTGT
GCTTCCTCCTGGTGTGTGTGGGCTTCTTTCTGTTTACCTTCACCAAGCTGTACGCCCGGCATTACGCGTGGACCTCGCTGGCTCTCACCC
TGCTGGTGTTCGCCCTGACCCTGGCTGCGCAGTTCCAGGTCTTGACGCCTGTCTCAGGACGCGGCGACAGCTCCAACCTTACGGCCACAG
CCCGGCCCACAGATACTTGCTTATCTCAAGTGGGGAGCTTCTCCATGTGCATCGAAGTGCTCTTTTTGCTCTATACCGTCATGCACTTAC
CTTTGTACCTGAGTTTGTGTCTGGGGGTGGCCTACTCTGTCCTTTTCGAGACCTTTGGCTACCATTTCCGGGATGAAGCCTGCTTCCCCT
CGCCCGGAGCCGGGGCCCTGCACTGGGAGCTGCTGAGCAGGGGGCTGCTCCACGGCTGCATCCACGCCATCGGGGTCCACCTGTTCGTCA
TGTCCCAGGTGAGGTCCAGGAGCACCTTCCTCAAGGTGGGGCAATCCATTATGCACGGGAAGGACCTGGAAGTGGAAAAAGCCCTCAAAG
AGAGGATGATTCATTCCGTGATGCCAAGAATCATAGCCGATGACTTAATGAAGCAGGGAGATGAGGAGAGTGAGAATTCTGTCAAGAGGC
ATGCCACCTCGAGCCCCAAGAACAGGAAGAAAAAGTCTTCCATCCAAAAAGCTCCTATAGCCTTCCGCCCTTTTAAGATGCAGCAGATCG
AAGAAGTCAGTATTTTATTTGCAGATATCGTGGGCTTCACCAAGATGAGTGCCAACAAGTCTGCCCACGCCCTGGTGGGTCTCCTGAACG
ATCTGTTCGGTCGCTTCGACCGCCTGTGTGAGGAGACCAAGTGTGAGAAAATCAGCACCCTGGGAGACTGTTACTACTGCGTGGCGGGCT
GTCCCGAGCCCCGGGCCGACCATGCCTACTGCTGCATCGAGATGGGCCTGGGCATGATCAAGGCCATCGAGCAGTTCTGCCAGGAGAAGA
AGGAGATGGTGAACATGAGAGTCGGGGTGCACACGGGCACCGTCCTTTGCGGCATCCTGGGCATGAGGAGGTTTAAATTTGACGTGTGGT
CCAACGATGTGAACCTGGCCAATCTCATGGAGCAGCTGGGAGTGGCCGGCAAAGTTCACATTTCTGAGGCCACCGCAAAATACTTAGATG
ACCGGTACGAAATGGAAGATGGGAAAGTTATTGAACGGCTGGGCCAGAGCGTGGTTGCTGACCAGTTGAAAGGTTTGAAGACATACCTGA
TATCGGGTCAGAGAGCCAAGGAGTCTCGCTGCAGCTGTGCAGAGGCCTTGCTTTCTGGCTTTGAGGTCATTGACGGCTCACAGGTGTCCT
CAGGCCCTAGGGGACAGGGGACAGCGTCATCAGGGAATGTCAGTGACTTGGCGCAGACTGTCAAAACCTTTGATAACCTTAAGACCTGCC
CTTCGTGCGGAATCACATTTGCTCCCAAATCTGAAGCCGGCGCCGAGGGAGGAGCACCTCAAAACGGCTGCCAAGACGAGCATAAAAACA
GCACCAAGGCTTCTGGAGGACCTAATCCCAAAACTCAGAACGGGCTCCTCAGCCCTCCCCAAGAGGAGAAGCTCACCAACAGTCAGACTT
CTCTGTGTGAGATCTTGCAGGAGAAGGGAAGGTGGGCAGGGGTGAGCCTGGACCAGTCGGCTCTCCTTCCGCTGAGGTTCAAGAACATCC
GGGAGAAAACGGACGCCCACTTTGTGGACGTTATCAAAGAAGACAGCCTGATGAAAGATTACTTTTTTAAGCCGCCCATTAATCAGTTCA
GCCTGAACTTCCTGGATCAGGAGCTGGAGCGATCCTACAGGACCAGCTATCAGGAAGAGGTGATTGTGTCCAGGGGGGGGCGCTTTCTGG
AAGCCCCCGTCTCAGGGAATCAGCAGCTGTCTAATGACGGGATGTTGGTGATCTTAGCGGCTGGAGACAGGGGCTTATATGAGGACTGCA
GCAGCTGCTTCCAGGCGATGGGGAAGACCTCCTTCTTCCTAGGTGAAGTGGGCAATGCAGCCAAGATGATGCTGATCGTGAACATGGTCC
AAGGGAGCTTCATGGCCACTATTGCCGAGGGGCTGACCCTGGCCCACGTGACAGGCCAGTCCCAGCAGACACTCTTGGACATCCTCAATC
AGGGACAGTTGGCCAGCATCTTCCTGGACCAGAAGTGCCAAAATATCCTGCAAGGAAACTTTAAGCCTGATTTCTACCTGAAATACATTC
AGAAGGATCTCCGCTTAGCCATTGCGCTGGGTGATGCGGTCAACCATCCGACTCCCATGGCAGCTGCAGCAAATGAGGTGTACAAAAGAG
CCAAGGCGCTGGACCAGTCTGACAACGATATGTCCGCCGTGTACCGAGCCTACATACACTAAGCTGTCGACACCCCGCCCTCACCCCTCC
AATCCCCCCTCTGACCCCCTCTTCCTCACATGGGGTCGGGGGCCTGGGAGTTCATTCTGGACCAGCCCACCTATCTCCATTTCCTTTTAT

>2258_2258_4_ADCY9-GLYR1_ADCY9_chr16_4038995_ENST00000294016_GLYR1_chr16_4862249_ENST00000591451_length(amino acids)=950AA_BP=770
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRW
WDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFP
SPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG
CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
DRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTC
PSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNI
REKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDC
SSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAHVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYI

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Fusion Gene PPI Analysis for ADCY9-GLYR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneGLYR1chr16:4038995chr16:4862249ENST000003219191116214_217373.0554.0histone H3
TgeneGLYR1chr16:4038995chr16:4862249ENST000003819831015214_217356.0537.0histone H3
TgeneGLYR1chr16:4038995chr16:4862249ENST000004366481015214_217292.0473.0histone H3
TgeneGLYR1chr16:4038995chr16:4862249ENST000005914511116214_217367.0548.0histone H3
TgeneGLYR1chr16:4038995chr16:4862249ENST000003219191116216_225373.0554.0KDM1B
TgeneGLYR1chr16:4038995chr16:4862249ENST000003819831015216_225356.0537.0KDM1B
TgeneGLYR1chr16:4038995chr16:4862249ENST000004366481015216_225292.0473.0KDM1B
TgeneGLYR1chr16:4038995chr16:4862249ENST000005914511116216_225367.0548.0KDM1B


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADCY9-GLYR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADCY9-GLYR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource