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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ADCY9-NMRAL1 (FusionGDB2 ID:2263)

Fusion Gene Summary for ADCY9-NMRAL1

Fusion gene summary

Fusion gene information	Fusion gene name: ADCY9-NMRAL1
	Fusion gene ID: 2263
		Hgene	Tgene
	Gene symbol	ADCY9	NMRAL1
	Gene ID	115	57407
	Gene name	adenylate cyclase 9	NmrA like redox sensor 1
	Synonyms	AC9\|ACIX	HSCARG\|SDR48A1
	Cytomap	16p13.3	16p13.3
	Type of gene	protein-coding	protein-coding
	Description	adenylate cyclase type 9ATP pyrophosphate-lyase 9adenylate cyclase type IXadenylyl cyclase 9type IX ATP pyrophosphate-lyase	nmrA-like family domain-containing protein 1NmrA-like family domain containing 1epididymis secretory sperm binding proteinshort chain dehydrogenase/reductase family 48A, member 1
	Modification date	20200313	20200313
	UniProtAcc	O60503	Q9HBL8
	Ensembl transtripts involved in fusion gene	ENST00000294016, ENST00000571889,	ENST00000572391, ENST00000283429, ENST00000404295, ENST00000574425, ENST00000574733,
Fusion gene scores	* DoF score	27 X 12 X 11=3564	4 X 3 X 4=48
	# samples	27	4
	** MAII score	log2(27/3564*10)=-3.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ADCY9 [Title/Abstract] AND NMRAL1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ADCY9(4163751)-NMRAL1(4519466), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ADCY9	GO:0006171	cAMP biosynthetic process	9628827\|10987815
Hgene	ADCY9	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	9628827

Fusion gene breakpoints across ADCY9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NMRAL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-DB-A64L-01A	ADCY9	chr16	4163751	-	NMRAL1	chr16	4519466	-

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Fusion Gene ORF analysis for ADCY9-NMRAL1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000294016	ENST00000572391	ADCY9	chr16	4163751	-	NMRAL1	chr16	4519466	-
In-frame	ENST00000294016	ENST00000283429	ADCY9	chr16	4163751	-	NMRAL1	chr16	4519466	-
In-frame	ENST00000294016	ENST00000404295	ADCY9	chr16	4163751	-	NMRAL1	chr16	4519466	-
In-frame	ENST00000294016	ENST00000574425	ADCY9	chr16	4163751	-	NMRAL1	chr16	4519466	-
In-frame	ENST00000294016	ENST00000574733	ADCY9	chr16	4163751	-	NMRAL1	chr16	4519466	-
intron-3CDS	ENST00000571889	ENST00000283429	ADCY9	chr16	4163751	-	NMRAL1	chr16	4519466	-
intron-3CDS	ENST00000571889	ENST00000404295	ADCY9	chr16	4163751	-	NMRAL1	chr16	4519466	-
intron-3CDS	ENST00000571889	ENST00000574425	ADCY9	chr16	4163751	-	NMRAL1	chr16	4519466	-
intron-3CDS	ENST00000571889	ENST00000574733	ADCY9	chr16	4163751	-	NMRAL1	chr16	4519466	-
intron-intron	ENST00000571889	ENST00000572391	ADCY9	chr16	4163751	-	NMRAL1	chr16	4519466	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000294016	ADCY9	chr16	4163751	-	ENST00000283429	NMRAL1	chr16	4519466	-	3192	2232	539	3091	850
ENST00000294016	ADCY9	chr16	4163751	-	ENST00000574733	NMRAL1	chr16	4519466	-	3181	2232	539	3091	850
ENST00000294016	ADCY9	chr16	4163751	-	ENST00000404295	NMRAL1	chr16	4519466	-	3178	2232	539	3091	850
ENST00000294016	ADCY9	chr16	4163751	-	ENST00000574425	NMRAL1	chr16	4519466	-	3177	2232	539	3091	850

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000294016	ENST00000283429	ADCY9	chr16	4163751	-	NMRAL1	chr16	4519466	-	0.007682542	0.99231744
ENST00000294016	ENST00000574733	ADCY9	chr16	4163751	-	NMRAL1	chr16	4519466	-	0.007588452	0.99241155
ENST00000294016	ENST00000404295	ADCY9	chr16	4163751	-	NMRAL1	chr16	4519466	-	0.007558711	0.9924413
ENST00000294016	ENST00000574425	ADCY9	chr16	4163751	-	NMRAL1	chr16	4519466	-	0.007658022	0.992342

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Fusion Genomic Features for ADCY9-NMRAL1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ADCY9-NMRAL1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:4163751/chr16:4519466)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ADCY9 O60503	NMRAL1 Q9HBL8
FUNCTION: Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269\|PubMed:10987815, ECO:0000269\|PubMed:12972952, ECO:0000269\|PubMed:15879435, ECO:0000269\|PubMed:9628827}.	FUNCTION: Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer. {ECO:0000269\|PubMed:17496144, ECO:0000269\|PubMed:18263583, ECO:0000269\|PubMed:19254724}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

394_521

564

1354.0

Domain

Guanylate cyclase 1

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

399_404

564

1354.0

Nucleotide binding

ATP

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

441_443

564

1354.0

Nucleotide binding

ATP

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

139_141

564

1354.0

Topological domain

Extracellular

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

163_171

564

1354.0

Topological domain

Cytoplasmic

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

193_215

564

1354.0

Topological domain

Extracellular

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

1_117

564

1354.0

Topological domain

Cytoplasmic

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

236_241

564

1354.0

Topological domain

Cytoplasmic

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

260_280

564

1354.0

Topological domain

Extracellular

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

118_138

564

1354.0

Transmembrane

Helical

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

142_162

564

1354.0

Transmembrane

Helical

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

172_192

564

1354.0

Transmembrane

Helical

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

216_235

564

1354.0

Transmembrane

Helical

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

242_259

564

1354.0

Transmembrane

Helical

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

281_301

564

1354.0

Transmembrane

Helical

Tgene

NMRAL1

chr16:4163751

chr16:4519466

ENST00000283429

11_16

300.0

Nucleotide binding

NADP

Tgene

NMRAL1

chr16:4163751

chr16:4519466

ENST00000283429

155_158

300.0

Nucleotide binding

NADP

Tgene

NMRAL1

chr16:4163751

chr16:4519466

ENST00000283429

37_41

300.0

Nucleotide binding

NADP

Tgene

NMRAL1

chr16:4163751

chr16:4519466

ENST00000283429

58_59

300.0

Nucleotide binding

NADP

Tgene

NMRAL1

chr16:4163751

chr16:4519466

ENST00000283429

79_81

300.0

Nucleotide binding

NADP

Tgene

NMRAL1

chr16:4163751

chr16:4519466

ENST00000404295

11_16

300.0

Nucleotide binding

NADP

Tgene

NMRAL1

chr16:4163751

chr16:4519466

ENST00000404295

155_158

300.0

Nucleotide binding

NADP

Tgene

NMRAL1

chr16:4163751

chr16:4519466

ENST00000404295

37_41

300.0

Nucleotide binding

NADP

Tgene

NMRAL1

chr16:4163751

chr16:4519466

ENST00000404295

58_59

300.0

Nucleotide binding

NADP

Tgene

NMRAL1

chr16:4163751

chr16:4519466

ENST00000404295

79_81

300.0

Nucleotide binding

NADP

Tgene

NMRAL1

chr16:4163751

chr16:4519466

ENST00000574425

11_16

300.0

Nucleotide binding

NADP

Tgene

NMRAL1

chr16:4163751

chr16:4519466

ENST00000574425

155_158

300.0

Nucleotide binding

NADP

Tgene

NMRAL1

chr16:4163751

chr16:4519466

ENST00000574425

37_41

300.0

Nucleotide binding

NADP

Tgene

NMRAL1

chr16:4163751

chr16:4519466

ENST00000574425

58_59

300.0

Nucleotide binding

NADP

Tgene

NMRAL1

chr16:4163751

chr16:4519466

ENST00000574425

79_81

300.0

Nucleotide binding

NADP

Tgene

NMRAL1

chr16:4163751

chr16:4519466

ENST00000574733

11_16

300.0

Nucleotide binding

NADP

Tgene

NMRAL1

chr16:4163751

chr16:4519466

ENST00000574733

155_158

300.0

Nucleotide binding

NADP

Tgene

NMRAL1

chr16:4163751

chr16:4519466

ENST00000574733

37_41

300.0

Nucleotide binding

NADP

Tgene

NMRAL1

chr16:4163751

chr16:4519466

ENST00000574733

58_59

300.0

Nucleotide binding

NADP

Tgene

NMRAL1

chr16:4163751

chr16:4519466

ENST00000574733

79_81

300.0

Nucleotide binding

NADP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

1058_1198

564

1354.0

Domain

Guanylate cyclase 2

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

1185_1187

564

1354.0

Nucleotide binding

ATP

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

1192_1196

564

1354.0

Nucleotide binding

ATP

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

302_786

564

1354.0

Topological domain

Cytoplasmic

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

808_818

564

1354.0

Topological domain

Extracellular

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

840_867

564

1354.0

Topological domain

Cytoplasmic

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

889_891

564

1354.0

Topological domain

Extracellular

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

913_920

564

1354.0

Topological domain

Cytoplasmic

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

942_975

564

1354.0

Topological domain

Extracellular

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

997_1353

564

1354.0

Topological domain

Cytoplasmic

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

787_807

564

1354.0

Transmembrane

Helical

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

819_839

564

1354.0

Transmembrane

Helical

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

868_888

564

1354.0

Transmembrane

Helical

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

892_912

564

1354.0

Transmembrane

Helical

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

921_941

564

1354.0

Transmembrane

Helical

Hgene

ADCY9

chr16:4163751

chr16:4519466

ENST00000294016

976_996

564

1354.0

Transmembrane

Helical

Top

Fusion Gene Sequence for ADCY9-NMRAL1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>2263_2263_1_ADCY9-NMRAL1_ADCY9_chr16_4163751_ENST00000294016_NMRAL1_chr16_4519466_ENST00000283429_length(transcript)=3192nt_BP=2232nt
GCGGCCGCGGCGGGAGCGGCGGCGCACTCGGGGGGAAGCAGGCCCCACTAGACGGGCCGCGCCGACGGGCTCCGCGCACTCGCAGCCCGG
GGCGCCCCCACCCCCAGCGCCCGCCGCCGCGGGCAGGGCCGGCCCGGAGCGCGGGGGGCGGCCGGGGAGCGCGAGCCGGGGGCGCCCGCC
GAAGCTCGCTGCTCCGGGTCGGGGTCCGGGCCCGGGGCCGGCCGCGCGCCGCCTTTGACGCATCGGAGCGCGGCTCCTGCAGGATGGAGG
GCTCCGCGCCGCCAGCGGAGTTGTTTGTGCGCAGGCGGCTCGCGGGGCTGGGAGCGCTCAAGGTCTGAACTTCCCTCCGGAGCCGCAGCT
GGAGGAGGCGAGCGCGCGAGGAGGAGAAGCCGCGCGGCGCGGAGGCCACCCTCGGGGCGAGAGGCGCGGAAGGCGAGCGAGCAAAGCGGT
CCCGGAGCCACGGCGGCCACGCGGCGGGGACCCCCGGGCGTTCTAGGTACTGGTGACCCCGGCCGGGGCAGGCCCCGGGACTCGACAACA
TGGCTTCCCCACCCCACCAGCAGCTGCTGCATCACCACAGCACCGAGGTGAGCTGCGACTCCAGCGGGGACAGCAACAGCGTGCGCGTCA
AGATCAACCCCAAGCAGCTGTCCTCCAACAGCCACCCCAAGCACTGCAAATACAGCATCTCCTCTAGCTGCAGCAGCTCTGGGGACTCCG
GGGGCGTCCCCCGGCGAGTGGGCGGCGGAGGCCGGCTGCGCAGGCAGAAGAAGCTGCCCCAGCTGTTCGAGAGGGCCTCCAGCCGCTGGT
GGGACCCCAAGTTCGACTCGGTGAACCTGGAGGAGGCCTGCCTGGAGCGCTGCTTCCCGCAGACCCAGCGCCGGTTCCGGTATGCGCTCT
TCTACATCGGCTTCGCCTGCCTTCTGTGGAGCATCTATTTTGCGGTCCACATGAGATCCAGACTGATCGTCATGGTCGCCCCCGCGCTGT
GCTTCCTCCTGGTGTGTGTGGGCTTCTTTCTGTTTACCTTCACCAAGCTGTACGCCCGGCATTACGCGTGGACCTCGCTGGCTCTCACCC
TGCTGGTGTTCGCCCTGACCCTGGCTGCGCAGTTCCAGGTCTTGACGCCTGTCTCAGGACGCGGCGACAGCTCCAACCTTACGGCCACAG
CCCGGCCCACAGATACTTGCTTATCTCAAGTGGGGAGCTTCTCCATGTGCATCGAAGTGCTCTTTTTGCTCTATACCGTCATGCACTTAC
CTTTGTACCTGAGTTTGTGTCTGGGGGTGGCCTACTCTGTCCTTTTCGAGACCTTTGGCTACCATTTCCGGGATGAAGCCTGCTTCCCCT
CGCCCGGAGCCGGGGCCCTGCACTGGGAGCTGCTGAGCAGGGGGCTGCTCCACGGCTGCATCCACGCCATCGGGGTCCACCTGTTCGTCA
TGTCCCAGGTGAGGTCCAGGAGCACCTTCCTCAAGGTGGGGCAATCCATTATGCACGGGAAGGACCTGGAAGTGGAAAAAGCCCTCAAAG
AGAGGATGATTCATTCCGTGATGCCAAGAATCATAGCCGATGACTTAATGAAGCAGGGAGATGAGGAGAGTGAGAATTCTGTCAAGAGGC
ATGCCACCTCGAGCCCCAAGAACAGGAAGAAAAAGTCTTCCATCCAAAAAGCTCCTATAGCCTTCCGCCCTTTTAAGATGCAGCAGATCG
AAGAAGTCAGTATTTTATTTGCAGATATCGTGGGCTTCACCAAGATGAGTGCCAACAAGTCTGCCCACGCCCTGGTGGGTCTCCTGAACG
ATCTGTTCGGTCGCTTCGACCGCCTGTGTGAGGAGACCAAGTGTGAGAAAATCAGCACCCTGGGAGACTGTTACTACTGCGTGGCGGGCT
GTCCCGAGCCCCGGGCCGACCATGCCTACTGCTGCATCGAGATGGGCCTGGGCATGATCAAGGCCATCGAGCAGTTCTGCCAGGAGAAGA
AGGAGATGGTGAACATGAGAGTCGGGGTGCACACGGGCACCGTCCTTTGCGGCATCCTGGGCATGAGGAGGTTTAAATTTGACGTGTGGT
CCAACGATGTGAACCTGGCCAATCTCATGGAGCAGCTGGGAGTGGCCGGCAAAGTTCACATTTCTGAGGCCACCGCAAAATACTTAGATG
ACCGGTACGAAATGGAAGATGGGAAAGTTATTGAACGGCTGGGCCAGAGCGTGGTTGCTGACCAGTTGAAAGGTGCCCAGGGTGGCTCCG
TGGCCCGCACACTCCTGGAAGATGGGACATTCAAGGTTCGAGTGGTGACCCGAAACCCTAGGAAGAAGGCAGCAAAGGAGCTGAGGCTGC
AAGGTGCAGAAGTAGTGCAGGGAGACCAAGATGACCAGGTCATCATGGAGCTGGCCCTGAATGGGGCTTACGCCACCTTCATCGTGACCA
ATTACTGGGAGAGCTGCAGCCAGGAGCAGGAGGTCAAGCAGGGGAAGCTGCTCGCTGATCTGGCCAGGCGCCTGGGCCTCCACTATGTGG
TCTACAGCGGCCTGGAGAACATCAAGAAGCTGACGGCAGGGAGATTGGCCGCCGCGCACTTTGACGGCAAAGGGGAGGTGGAGGAATATT
TCCGGGACATTGGCGTTCCCATGACCAGTGTGCGGCTGCCCTGCTATTTTGAGAACCTCCTCTCCCACTTCTTGCCCCAGAAAGCCCCAG
ACGGAAAGAGCTACTTGCTGAGCTTGCCCACAGGTGACGTTCCCATGGATGGCATGTCCGTGTCTGACCTGGGTCCTGTGGTGCTCAGCC
TTTTGAAGATGCCAGAAAAATACGTCGGCCAGAACATCGGGCTGAGCACTTGCAGGCACACGGCCGAGGAGTACGCTGCCCTGCTCACCA
AGCACACCCGCAAGGTCGTGCACGATGCCAAGATGACTCCTGAGGACTACGAAAAGCTTGGCTTTCCCGGTGCCCGGGACCTGGCCAACA
TGTTCCGTTTCTATGCCCTGAGACCCGACCGTGACATCGAGCTGACCCTGAGACTCAACCCCAAGGCCCTGACGCTGGACCAGTGGCTGG
AACAGCACAAAGGGGACTTCAACCTGCTGTGACCTGCCCGCCTCGCGGCCCCTTGTGGGGATCGGGGGCACCAGAGGGGCAGAGGCACCA

>2263_2263_1_ADCY9-NMRAL1_ADCY9_chr16_4163751_ENST00000294016_NMRAL1_chr16_4519466_ENST00000283429_length(amino acids)=850AA_BP=564
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRW
WDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFP
SPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG
CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
DRYEMEDGKVIERLGQSVVADQLKGAQGGSVARTLLEDGTFKVRVVTRNPRKKAAKELRLQGAEVVQGDQDDQVIMELALNGAYATFIVT
NYWESCSQEQEVKQGKLLADLARRLGLHYVVYSGLENIKKLTAGRLAAAHFDGKGEVEEYFRDIGVPMTSVRLPCYFENLLSHFLPQKAP
DGKSYLLSLPTGDVPMDGMSVSDLGPVVLSLLKMPEKYVGQNIGLSTCRHTAEEYAALLTKHTRKVVHDAKMTPEDYEKLGFPGARDLAN

--------------------------------------------------------------
>2263_2263_2_ADCY9-NMRAL1_ADCY9_chr16_4163751_ENST00000294016_NMRAL1_chr16_4519466_ENST00000404295_length(transcript)=3178nt_BP=2232nt
GCGGCCGCGGCGGGAGCGGCGGCGCACTCGGGGGGAAGCAGGCCCCACTAGACGGGCCGCGCCGACGGGCTCCGCGCACTCGCAGCCCGG
GGCGCCCCCACCCCCAGCGCCCGCCGCCGCGGGCAGGGCCGGCCCGGAGCGCGGGGGGCGGCCGGGGAGCGCGAGCCGGGGGCGCCCGCC
GAAGCTCGCTGCTCCGGGTCGGGGTCCGGGCCCGGGGCCGGCCGCGCGCCGCCTTTGACGCATCGGAGCGCGGCTCCTGCAGGATGGAGG
GCTCCGCGCCGCCAGCGGAGTTGTTTGTGCGCAGGCGGCTCGCGGGGCTGGGAGCGCTCAAGGTCTGAACTTCCCTCCGGAGCCGCAGCT
GGAGGAGGCGAGCGCGCGAGGAGGAGAAGCCGCGCGGCGCGGAGGCCACCCTCGGGGCGAGAGGCGCGGAAGGCGAGCGAGCAAAGCGGT
CCCGGAGCCACGGCGGCCACGCGGCGGGGACCCCCGGGCGTTCTAGGTACTGGTGACCCCGGCCGGGGCAGGCCCCGGGACTCGACAACA
TGGCTTCCCCACCCCACCAGCAGCTGCTGCATCACCACAGCACCGAGGTGAGCTGCGACTCCAGCGGGGACAGCAACAGCGTGCGCGTCA
AGATCAACCCCAAGCAGCTGTCCTCCAACAGCCACCCCAAGCACTGCAAATACAGCATCTCCTCTAGCTGCAGCAGCTCTGGGGACTCCG
GGGGCGTCCCCCGGCGAGTGGGCGGCGGAGGCCGGCTGCGCAGGCAGAAGAAGCTGCCCCAGCTGTTCGAGAGGGCCTCCAGCCGCTGGT
GGGACCCCAAGTTCGACTCGGTGAACCTGGAGGAGGCCTGCCTGGAGCGCTGCTTCCCGCAGACCCAGCGCCGGTTCCGGTATGCGCTCT
TCTACATCGGCTTCGCCTGCCTTCTGTGGAGCATCTATTTTGCGGTCCACATGAGATCCAGACTGATCGTCATGGTCGCCCCCGCGCTGT
GCTTCCTCCTGGTGTGTGTGGGCTTCTTTCTGTTTACCTTCACCAAGCTGTACGCCCGGCATTACGCGTGGACCTCGCTGGCTCTCACCC
TGCTGGTGTTCGCCCTGACCCTGGCTGCGCAGTTCCAGGTCTTGACGCCTGTCTCAGGACGCGGCGACAGCTCCAACCTTACGGCCACAG
CCCGGCCCACAGATACTTGCTTATCTCAAGTGGGGAGCTTCTCCATGTGCATCGAAGTGCTCTTTTTGCTCTATACCGTCATGCACTTAC
CTTTGTACCTGAGTTTGTGTCTGGGGGTGGCCTACTCTGTCCTTTTCGAGACCTTTGGCTACCATTTCCGGGATGAAGCCTGCTTCCCCT
CGCCCGGAGCCGGGGCCCTGCACTGGGAGCTGCTGAGCAGGGGGCTGCTCCACGGCTGCATCCACGCCATCGGGGTCCACCTGTTCGTCA
TGTCCCAGGTGAGGTCCAGGAGCACCTTCCTCAAGGTGGGGCAATCCATTATGCACGGGAAGGACCTGGAAGTGGAAAAAGCCCTCAAAG
AGAGGATGATTCATTCCGTGATGCCAAGAATCATAGCCGATGACTTAATGAAGCAGGGAGATGAGGAGAGTGAGAATTCTGTCAAGAGGC
ATGCCACCTCGAGCCCCAAGAACAGGAAGAAAAAGTCTTCCATCCAAAAAGCTCCTATAGCCTTCCGCCCTTTTAAGATGCAGCAGATCG
AAGAAGTCAGTATTTTATTTGCAGATATCGTGGGCTTCACCAAGATGAGTGCCAACAAGTCTGCCCACGCCCTGGTGGGTCTCCTGAACG
ATCTGTTCGGTCGCTTCGACCGCCTGTGTGAGGAGACCAAGTGTGAGAAAATCAGCACCCTGGGAGACTGTTACTACTGCGTGGCGGGCT
GTCCCGAGCCCCGGGCCGACCATGCCTACTGCTGCATCGAGATGGGCCTGGGCATGATCAAGGCCATCGAGCAGTTCTGCCAGGAGAAGA
AGGAGATGGTGAACATGAGAGTCGGGGTGCACACGGGCACCGTCCTTTGCGGCATCCTGGGCATGAGGAGGTTTAAATTTGACGTGTGGT
CCAACGATGTGAACCTGGCCAATCTCATGGAGCAGCTGGGAGTGGCCGGCAAAGTTCACATTTCTGAGGCCACCGCAAAATACTTAGATG
ACCGGTACGAAATGGAAGATGGGAAAGTTATTGAACGGCTGGGCCAGAGCGTGGTTGCTGACCAGTTGAAAGGTGCCCAGGGTGGCTCCG
TGGCCCGCACACTCCTGGAAGATGGGACATTCAAGGTTCGAGTGGTGACCCGAAACCCTAGGAAGAAGGCAGCAAAGGAGCTGAGGCTGC
AAGGTGCAGAAGTAGTGCAGGGAGACCAAGATGACCAGGTCATCATGGAGCTGGCCCTGAATGGGGCTTACGCCACCTTCATCGTGACCA
ATTACTGGGAGAGCTGCAGCCAGGAGCAGGAGGTCAAGCAGGGGAAGCTGCTCGCTGATCTGGCCAGGCGCCTGGGCCTCCACTATGTGG
TCTACAGCGGCCTGGAGAACATCAAGAAGCTGACGGCAGGGAGATTGGCCGCCGCGCACTTTGACGGCAAAGGGGAGGTGGAGGAATATT
TCCGGGACATTGGCGTTCCCATGACCAGTGTGCGGCTGCCCTGCTATTTTGAGAACCTCCTCTCCCACTTCTTGCCCCAGAAAGCCCCAG
ACGGAAAGAGCTACTTGCTGAGCTTGCCCACAGGTGACGTTCCCATGGATGGCATGTCCGTGTCTGACCTGGGTCCTGTGGTGCTCAGCC
TTTTGAAGATGCCAGAAAAATACGTCGGCCAGAACATCGGGCTGAGCACTTGCAGGCACACGGCCGAGGAGTACGCTGCCCTGCTCACCA
AGCACACCCGCAAGGTCGTGCACGATGCCAAGATGACTCCTGAGGACTACGAAAAGCTTGGCTTTCCCGGTGCCCGGGACCTGGCCAACA
TGTTCCGTTTCTATGCCCTGAGACCCGACCGTGACATCGAGCTGACCCTGAGACTCAACCCCAAGGCCCTGACGCTGGACCAGTGGCTGG
AACAGCACAAAGGGGACTTCAACCTGCTGTGACCTGCCCGCCTCGCGGCCCCTTGTGGGGATCGGGGGCACCAGAGGGGCAGAGGCACCA

>2263_2263_2_ADCY9-NMRAL1_ADCY9_chr16_4163751_ENST00000294016_NMRAL1_chr16_4519466_ENST00000404295_length(amino acids)=850AA_BP=564
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRW
WDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFP
SPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG
CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
DRYEMEDGKVIERLGQSVVADQLKGAQGGSVARTLLEDGTFKVRVVTRNPRKKAAKELRLQGAEVVQGDQDDQVIMELALNGAYATFIVT
NYWESCSQEQEVKQGKLLADLARRLGLHYVVYSGLENIKKLTAGRLAAAHFDGKGEVEEYFRDIGVPMTSVRLPCYFENLLSHFLPQKAP
DGKSYLLSLPTGDVPMDGMSVSDLGPVVLSLLKMPEKYVGQNIGLSTCRHTAEEYAALLTKHTRKVVHDAKMTPEDYEKLGFPGARDLAN

--------------------------------------------------------------
>2263_2263_3_ADCY9-NMRAL1_ADCY9_chr16_4163751_ENST00000294016_NMRAL1_chr16_4519466_ENST00000574425_length(transcript)=3177nt_BP=2232nt
GCGGCCGCGGCGGGAGCGGCGGCGCACTCGGGGGGAAGCAGGCCCCACTAGACGGGCCGCGCCGACGGGCTCCGCGCACTCGCAGCCCGG
GGCGCCCCCACCCCCAGCGCCCGCCGCCGCGGGCAGGGCCGGCCCGGAGCGCGGGGGGCGGCCGGGGAGCGCGAGCCGGGGGCGCCCGCC
GAAGCTCGCTGCTCCGGGTCGGGGTCCGGGCCCGGGGCCGGCCGCGCGCCGCCTTTGACGCATCGGAGCGCGGCTCCTGCAGGATGGAGG
GCTCCGCGCCGCCAGCGGAGTTGTTTGTGCGCAGGCGGCTCGCGGGGCTGGGAGCGCTCAAGGTCTGAACTTCCCTCCGGAGCCGCAGCT
GGAGGAGGCGAGCGCGCGAGGAGGAGAAGCCGCGCGGCGCGGAGGCCACCCTCGGGGCGAGAGGCGCGGAAGGCGAGCGAGCAAAGCGGT
CCCGGAGCCACGGCGGCCACGCGGCGGGGACCCCCGGGCGTTCTAGGTACTGGTGACCCCGGCCGGGGCAGGCCCCGGGACTCGACAACA
TGGCTTCCCCACCCCACCAGCAGCTGCTGCATCACCACAGCACCGAGGTGAGCTGCGACTCCAGCGGGGACAGCAACAGCGTGCGCGTCA
AGATCAACCCCAAGCAGCTGTCCTCCAACAGCCACCCCAAGCACTGCAAATACAGCATCTCCTCTAGCTGCAGCAGCTCTGGGGACTCCG
GGGGCGTCCCCCGGCGAGTGGGCGGCGGAGGCCGGCTGCGCAGGCAGAAGAAGCTGCCCCAGCTGTTCGAGAGGGCCTCCAGCCGCTGGT
GGGACCCCAAGTTCGACTCGGTGAACCTGGAGGAGGCCTGCCTGGAGCGCTGCTTCCCGCAGACCCAGCGCCGGTTCCGGTATGCGCTCT
TCTACATCGGCTTCGCCTGCCTTCTGTGGAGCATCTATTTTGCGGTCCACATGAGATCCAGACTGATCGTCATGGTCGCCCCCGCGCTGT
GCTTCCTCCTGGTGTGTGTGGGCTTCTTTCTGTTTACCTTCACCAAGCTGTACGCCCGGCATTACGCGTGGACCTCGCTGGCTCTCACCC
TGCTGGTGTTCGCCCTGACCCTGGCTGCGCAGTTCCAGGTCTTGACGCCTGTCTCAGGACGCGGCGACAGCTCCAACCTTACGGCCACAG
CCCGGCCCACAGATACTTGCTTATCTCAAGTGGGGAGCTTCTCCATGTGCATCGAAGTGCTCTTTTTGCTCTATACCGTCATGCACTTAC
CTTTGTACCTGAGTTTGTGTCTGGGGGTGGCCTACTCTGTCCTTTTCGAGACCTTTGGCTACCATTTCCGGGATGAAGCCTGCTTCCCCT
CGCCCGGAGCCGGGGCCCTGCACTGGGAGCTGCTGAGCAGGGGGCTGCTCCACGGCTGCATCCACGCCATCGGGGTCCACCTGTTCGTCA
TGTCCCAGGTGAGGTCCAGGAGCACCTTCCTCAAGGTGGGGCAATCCATTATGCACGGGAAGGACCTGGAAGTGGAAAAAGCCCTCAAAG
AGAGGATGATTCATTCCGTGATGCCAAGAATCATAGCCGATGACTTAATGAAGCAGGGAGATGAGGAGAGTGAGAATTCTGTCAAGAGGC
ATGCCACCTCGAGCCCCAAGAACAGGAAGAAAAAGTCTTCCATCCAAAAAGCTCCTATAGCCTTCCGCCCTTTTAAGATGCAGCAGATCG
AAGAAGTCAGTATTTTATTTGCAGATATCGTGGGCTTCACCAAGATGAGTGCCAACAAGTCTGCCCACGCCCTGGTGGGTCTCCTGAACG
ATCTGTTCGGTCGCTTCGACCGCCTGTGTGAGGAGACCAAGTGTGAGAAAATCAGCACCCTGGGAGACTGTTACTACTGCGTGGCGGGCT
GTCCCGAGCCCCGGGCCGACCATGCCTACTGCTGCATCGAGATGGGCCTGGGCATGATCAAGGCCATCGAGCAGTTCTGCCAGGAGAAGA
AGGAGATGGTGAACATGAGAGTCGGGGTGCACACGGGCACCGTCCTTTGCGGCATCCTGGGCATGAGGAGGTTTAAATTTGACGTGTGGT
CCAACGATGTGAACCTGGCCAATCTCATGGAGCAGCTGGGAGTGGCCGGCAAAGTTCACATTTCTGAGGCCACCGCAAAATACTTAGATG
ACCGGTACGAAATGGAAGATGGGAAAGTTATTGAACGGCTGGGCCAGAGCGTGGTTGCTGACCAGTTGAAAGGTGCCCAGGGTGGCTCCG
TGGCCCGCACACTCCTGGAAGATGGGACATTCAAGGTTCGAGTGGTGACCCGAAACCCTAGGAAGAAGGCAGCAAAGGAGCTGAGGCTGC
AAGGTGCAGAAGTAGTGCAGGGAGACCAAGATGACCAGGTCATCATGGAGCTGGCCCTGAATGGGGCTTACGCCACCTTCATCGTGACCA
ATTACTGGGAGAGCTGCAGCCAGGAGCAGGAGGTCAAGCAGGGGAAGCTGCTCGCTGATCTGGCCAGGCGCCTGGGCCTCCACTATGTGG
TCTACAGCGGCCTGGAGAACATCAAGAAGCTGACGGCAGGGAGATTGGCCGCCGCGCACTTTGACGGCAAAGGGGAGGTGGAGGAATATT
TCCGGGACATTGGCGTTCCCATGACCAGTGTGCGGCTGCCCTGCTATTTTGAGAACCTCCTCTCCCACTTCTTGCCCCAGAAAGCCCCAG
ACGGAAAGAGCTACTTGCTGAGCTTGCCCACAGGTGACGTTCCCATGGATGGCATGTCCGTGTCTGACCTGGGTCCTGTGGTGCTCAGCC
TTTTGAAGATGCCAGAAAAATACGTCGGCCAGAACATCGGGCTGAGCACTTGCAGGCACACGGCCGAGGAGTACGCTGCCCTGCTCACCA
AGCACACCCGCAAGGTCGTGCACGATGCCAAGATGACTCCTGAGGACTACGAAAAGCTTGGCTTTCCCGGTGCCCGGGACCTGGCCAACA
TGTTCCGTTTCTATGCCCTGAGACCCGACCGTGACATCGAGCTGACCCTGAGACTCAACCCCAAGGCCCTGACGCTGGACCAGTGGCTGG
AACAGCACAAAGGGGACTTCAACCTGCTGTGACCTGCCCGCCTCGCGGCCCCTTGTGGGGATCGGGGGCACCAGAGGGGCAGAGGCACCA

>2263_2263_3_ADCY9-NMRAL1_ADCY9_chr16_4163751_ENST00000294016_NMRAL1_chr16_4519466_ENST00000574425_length(amino acids)=850AA_BP=564
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRW
WDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFP
SPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG
CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
DRYEMEDGKVIERLGQSVVADQLKGAQGGSVARTLLEDGTFKVRVVTRNPRKKAAKELRLQGAEVVQGDQDDQVIMELALNGAYATFIVT
NYWESCSQEQEVKQGKLLADLARRLGLHYVVYSGLENIKKLTAGRLAAAHFDGKGEVEEYFRDIGVPMTSVRLPCYFENLLSHFLPQKAP
DGKSYLLSLPTGDVPMDGMSVSDLGPVVLSLLKMPEKYVGQNIGLSTCRHTAEEYAALLTKHTRKVVHDAKMTPEDYEKLGFPGARDLAN

--------------------------------------------------------------
>2263_2263_4_ADCY9-NMRAL1_ADCY9_chr16_4163751_ENST00000294016_NMRAL1_chr16_4519466_ENST00000574733_length(transcript)=3181nt_BP=2232nt
GCGGCCGCGGCGGGAGCGGCGGCGCACTCGGGGGGAAGCAGGCCCCACTAGACGGGCCGCGCCGACGGGCTCCGCGCACTCGCAGCCCGG
GGCGCCCCCACCCCCAGCGCCCGCCGCCGCGGGCAGGGCCGGCCCGGAGCGCGGGGGGCGGCCGGGGAGCGCGAGCCGGGGGCGCCCGCC
GAAGCTCGCTGCTCCGGGTCGGGGTCCGGGCCCGGGGCCGGCCGCGCGCCGCCTTTGACGCATCGGAGCGCGGCTCCTGCAGGATGGAGG
GCTCCGCGCCGCCAGCGGAGTTGTTTGTGCGCAGGCGGCTCGCGGGGCTGGGAGCGCTCAAGGTCTGAACTTCCCTCCGGAGCCGCAGCT
GGAGGAGGCGAGCGCGCGAGGAGGAGAAGCCGCGCGGCGCGGAGGCCACCCTCGGGGCGAGAGGCGCGGAAGGCGAGCGAGCAAAGCGGT
CCCGGAGCCACGGCGGCCACGCGGCGGGGACCCCCGGGCGTTCTAGGTACTGGTGACCCCGGCCGGGGCAGGCCCCGGGACTCGACAACA
TGGCTTCCCCACCCCACCAGCAGCTGCTGCATCACCACAGCACCGAGGTGAGCTGCGACTCCAGCGGGGACAGCAACAGCGTGCGCGTCA
AGATCAACCCCAAGCAGCTGTCCTCCAACAGCCACCCCAAGCACTGCAAATACAGCATCTCCTCTAGCTGCAGCAGCTCTGGGGACTCCG
GGGGCGTCCCCCGGCGAGTGGGCGGCGGAGGCCGGCTGCGCAGGCAGAAGAAGCTGCCCCAGCTGTTCGAGAGGGCCTCCAGCCGCTGGT
GGGACCCCAAGTTCGACTCGGTGAACCTGGAGGAGGCCTGCCTGGAGCGCTGCTTCCCGCAGACCCAGCGCCGGTTCCGGTATGCGCTCT
TCTACATCGGCTTCGCCTGCCTTCTGTGGAGCATCTATTTTGCGGTCCACATGAGATCCAGACTGATCGTCATGGTCGCCCCCGCGCTGT
GCTTCCTCCTGGTGTGTGTGGGCTTCTTTCTGTTTACCTTCACCAAGCTGTACGCCCGGCATTACGCGTGGACCTCGCTGGCTCTCACCC
TGCTGGTGTTCGCCCTGACCCTGGCTGCGCAGTTCCAGGTCTTGACGCCTGTCTCAGGACGCGGCGACAGCTCCAACCTTACGGCCACAG
CCCGGCCCACAGATACTTGCTTATCTCAAGTGGGGAGCTTCTCCATGTGCATCGAAGTGCTCTTTTTGCTCTATACCGTCATGCACTTAC
CTTTGTACCTGAGTTTGTGTCTGGGGGTGGCCTACTCTGTCCTTTTCGAGACCTTTGGCTACCATTTCCGGGATGAAGCCTGCTTCCCCT
CGCCCGGAGCCGGGGCCCTGCACTGGGAGCTGCTGAGCAGGGGGCTGCTCCACGGCTGCATCCACGCCATCGGGGTCCACCTGTTCGTCA
TGTCCCAGGTGAGGTCCAGGAGCACCTTCCTCAAGGTGGGGCAATCCATTATGCACGGGAAGGACCTGGAAGTGGAAAAAGCCCTCAAAG
AGAGGATGATTCATTCCGTGATGCCAAGAATCATAGCCGATGACTTAATGAAGCAGGGAGATGAGGAGAGTGAGAATTCTGTCAAGAGGC
ATGCCACCTCGAGCCCCAAGAACAGGAAGAAAAAGTCTTCCATCCAAAAAGCTCCTATAGCCTTCCGCCCTTTTAAGATGCAGCAGATCG
AAGAAGTCAGTATTTTATTTGCAGATATCGTGGGCTTCACCAAGATGAGTGCCAACAAGTCTGCCCACGCCCTGGTGGGTCTCCTGAACG
ATCTGTTCGGTCGCTTCGACCGCCTGTGTGAGGAGACCAAGTGTGAGAAAATCAGCACCCTGGGAGACTGTTACTACTGCGTGGCGGGCT
GTCCCGAGCCCCGGGCCGACCATGCCTACTGCTGCATCGAGATGGGCCTGGGCATGATCAAGGCCATCGAGCAGTTCTGCCAGGAGAAGA
AGGAGATGGTGAACATGAGAGTCGGGGTGCACACGGGCACCGTCCTTTGCGGCATCCTGGGCATGAGGAGGTTTAAATTTGACGTGTGGT
CCAACGATGTGAACCTGGCCAATCTCATGGAGCAGCTGGGAGTGGCCGGCAAAGTTCACATTTCTGAGGCCACCGCAAAATACTTAGATG
ACCGGTACGAAATGGAAGATGGGAAAGTTATTGAACGGCTGGGCCAGAGCGTGGTTGCTGACCAGTTGAAAGGTGCCCAGGGTGGCTCCG
TGGCCCGCACACTCCTGGAAGATGGGACATTCAAGGTTCGAGTGGTGACCCGAAACCCTAGGAAGAAGGCAGCAAAGGAGCTGAGGCTGC
AAGGTGCAGAAGTAGTGCAGGGAGACCAAGATGACCAGGTCATCATGGAGCTGGCCCTGAATGGGGCTTACGCCACCTTCATCGTGACCA
ATTACTGGGAGAGCTGCAGCCAGGAGCAGGAGGTCAAGCAGGGGAAGCTGCTCGCTGATCTGGCCAGGCGCCTGGGCCTCCACTATGTGG
TCTACAGCGGCCTGGAGAACATCAAGAAGCTGACGGCAGGGAGATTGGCCGCCGCGCACTTTGACGGCAAAGGGGAGGTGGAGGAATATT
TCCGGGACATTGGCGTTCCCATGACCAGTGTGCGGCTGCCCTGCTATTTTGAGAACCTCCTCTCCCACTTCTTGCCCCAGAAAGCCCCAG
ACGGAAAGAGCTACTTGCTGAGCTTGCCCACAGGTGACGTTCCCATGGATGGCATGTCCGTGTCTGACCTGGGTCCTGTGGTGCTCAGCC
TTTTGAAGATGCCAGAAAAATACGTCGGCCAGAACATCGGGCTGAGCACTTGCAGGCACACGGCCGAGGAGTACGCTGCCCTGCTCACCA
AGCACACCCGCAAGGTCGTGCACGATGCCAAGATGACTCCTGAGGACTACGAAAAGCTTGGCTTTCCCGGTGCCCGGGACCTGGCCAACA
TGTTCCGTTTCTATGCCCTGAGACCCGACCGTGACATCGAGCTGACCCTGAGACTCAACCCCAAGGCCCTGACGCTGGACCAGTGGCTGG
AACAGCACAAAGGGGACTTCAACCTGCTGTGACCTGCCCGCCTCGCGGCCCCTTGTGGGGATCGGGGGCACCAGAGGGGCAGAGGCACCA

>2263_2263_4_ADCY9-NMRAL1_ADCY9_chr16_4163751_ENST00000294016_NMRAL1_chr16_4519466_ENST00000574733_length(amino acids)=850AA_BP=564
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRW
WDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFP
SPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG
CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
DRYEMEDGKVIERLGQSVVADQLKGAQGGSVARTLLEDGTFKVRVVTRNPRKKAAKELRLQGAEVVQGDQDDQVIMELALNGAYATFIVT
NYWESCSQEQEVKQGKLLADLARRLGLHYVVYSGLENIKKLTAGRLAAAHFDGKGEVEEYFRDIGVPMTSVRLPCYFENLLSHFLPQKAP
DGKSYLLSLPTGDVPMDGMSVSDLGPVVLSLLKMPEKYVGQNIGLSTCRHTAEEYAALLTKHTRKVVHDAKMTPEDYEKLGFPGARDLAN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ADCY9-NMRAL1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	NMRAL1	chr16:4163751	chr16:4519466	ENST00000283429		1	6	153_189	13.333333333333334	300.0	ASS1
Tgene	NMRAL1	chr16:4163751	chr16:4519466	ENST00000404295		1	6	153_189	13.333333333333334	300.0	ASS1
Tgene	NMRAL1	chr16:4163751	chr16:4519466	ENST00000574425		1	6	153_189	13.333333333333334	300.0	ASS1
Tgene	NMRAL1	chr16:4163751	chr16:4519466	ENST00000574733		1	6	153_189	13.333333333333334	300.0	ASS1

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ADCY9-NMRAL1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ADCY9-NMRAL1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source