Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DHX15-CCDC149 (FusionGDB2 ID:22631)

Fusion Gene Summary for DHX15-CCDC149

Fusion gene summary

Fusion gene information	Fusion gene name: DHX15-CCDC149
	Fusion gene ID: 22631
		Hgene	Tgene
	Gene symbol	DHX15	CCDC149
	Gene ID	1665	91050
	Gene name	DEAH-box helicase 15	coiled-coil domain containing 149
	Synonyms	DBP1\|DDX15\|HRH2\|PRP43\|PRPF43\|PrPp43p	-
	Cytomap	4p15.2	4p15.2
	Type of gene	protein-coding	protein-coding
	Description	pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15ATP-dependent RNA helicase #46DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15DEAD/H box-15DEAH (Asp-Glu-Ala-His) box helicase 15DEAH (Asp-Glu-Ala-His) box polypeptide 15DEAH box protein 15RNA	coiled-coil domain-containing protein 149
	Modification date	20200313	20200313
	UniProtAcc	O43143	Q6ZUS6
	Ensembl transtripts involved in fusion gene	ENST00000336812, ENST00000508032,	ENST00000389609, ENST00000428116, ENST00000502801, ENST00000508236, ENST00000504487,
Fusion gene scores	* DoF score	9 X 8 X 5=360	4 X 4 X 4=64
	# samples	9	4
	** MAII score	log2(9/360*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DHX15 [Title/Abstract] AND CCDC149 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DHX15(24550478)-CCDC149(24839894), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across DHX15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CCDC149 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CG-4449-01A	DHX15	chr4	24550478	-	CCDC149	chr4	24839894	-

Top

Fusion Gene ORF analysis for DHX15-CCDC149

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000336812	ENST00000389609	DHX15	chr4	24550478	-	CCDC149	chr4	24839894	-
5CDS-intron	ENST00000336812	ENST00000428116	DHX15	chr4	24550478	-	CCDC149	chr4	24839894	-
5CDS-intron	ENST00000336812	ENST00000502801	DHX15	chr4	24550478	-	CCDC149	chr4	24839894	-
5CDS-intron	ENST00000336812	ENST00000508236	DHX15	chr4	24550478	-	CCDC149	chr4	24839894	-
In-frame	ENST00000336812	ENST00000504487	DHX15	chr4	24550478	-	CCDC149	chr4	24839894	-
intron-3CDS	ENST00000508032	ENST00000504487	DHX15	chr4	24550478	-	CCDC149	chr4	24839894	-
intron-intron	ENST00000508032	ENST00000389609	DHX15	chr4	24550478	-	CCDC149	chr4	24839894	-
intron-intron	ENST00000508032	ENST00000428116	DHX15	chr4	24550478	-	CCDC149	chr4	24839894	-
intron-intron	ENST00000508032	ENST00000502801	DHX15	chr4	24550478	-	CCDC149	chr4	24839894	-
intron-intron	ENST00000508032	ENST00000508236	DHX15	chr4	24550478	-	CCDC149	chr4	24839894	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000336812

DHX15

chr4

24550478

ENST00000504487

CCDC149

chr4

24839894

4895

1405

2622

841

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000336812	ENST00000504487	DHX15	chr4	24550478	-	CCDC149	chr4	24839894	-	0.002195115	0.99780494

Top

Fusion Genomic Features for DHX15-CCDC149

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for DHX15-CCDC149

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:24550478/chr4:24839894)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DHX15 O43143	CCDC149 Q6ZUS6
FUNCTION: Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. {ECO:0000269\|PubMed:19103666}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DHX15

chr4:24550478

chr4:24839894

ENST00000336812

147_313

416

796.0

Domain

Helicase ATP-binding

Hgene

DHX15

chr4:24550478

chr4:24839894

ENST00000336812

260_263

416

796.0

Motif

Note=DEAH box

Hgene

DHX15

chr4:24550478

chr4:24839894

ENST00000336812

160_167

416

796.0

Nucleotide binding

ATP

Tgene

CCDC149

chr4:24550478

chr4:24839894

ENST00000389609

259_286

124

530.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCDC149

chr4:24550478

chr4:24839894

ENST00000389609

385_414

124

530.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCDC149

chr4:24550478

chr4:24839894

ENST00000428116

1_199

87.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCDC149

chr4:24550478

chr4:24839894

ENST00000428116

259_286

87.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCDC149

chr4:24550478

chr4:24839894

ENST00000428116

385_414

87.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCDC149

chr4:24550478

chr4:24839894

ENST00000502801

1_199

142.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCDC149

chr4:24550478

chr4:24839894

ENST00000502801

259_286

142.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCDC149

chr4:24550478

chr4:24839894

ENST00000502801

385_414

142.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCDC149

chr4:24550478

chr4:24839894

ENST00000504487

259_286

124

530.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCDC149

chr4:24550478

chr4:24839894

ENST00000504487

385_414

124

530.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCDC149

chr4:24550478

chr4:24839894

ENST00000389609

205_208

124

530.0

Compositional bias

Note=Poly-Ser

Tgene

CCDC149

chr4:24550478

chr4:24839894

ENST00000428116

205_208

87.0

Compositional bias

Note=Poly-Ser

Tgene

CCDC149

chr4:24550478

chr4:24839894

ENST00000502801

205_208

142.0

Compositional bias

Note=Poly-Ser

Tgene

CCDC149

chr4:24550478

chr4:24839894

ENST00000504487

205_208

124

530.0

Compositional bias

Note=Poly-Ser

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DHX15

chr4:24550478

chr4:24839894

ENST00000336812

338_518

416

796.0

Domain

Helicase C-terminal

Tgene

CCDC149

chr4:24550478

chr4:24839894

ENST00000389609

1_199

124

530.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCDC149

chr4:24550478

chr4:24839894

ENST00000504487

1_199

124

530.0

Coiled coil

Ontology_term=ECO:0000255

Top

Fusion Gene Sequence for DHX15-CCDC149

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>22631_22631_1_DHX15-CCDC149_DHX15_chr4_24550478_ENST00000336812_CCDC149_chr4_24839894_ENST00000504487_length(transcript)=4895nt_BP=1405nt
TCGCCGCCGCCATTTTAGCTGTTGGTTCCGGCCGCACCGTGTGGGCTGTAGTAGCGGGAGGGGTGGGGGTCCTCCAGAGTTAAGTGGCTG
TCCTCGACTGTGCCCATACAGCAGCCAGCTTTCTTCCTTAATAACTGCCCGTTCGAAGAGTGCGAGGATGTCCAAGCGGCACCGGTTGGA
CCTAGGGGAGGATTACCCCTCTGGCAAGAAGCGTGCGGGGACCGATGGGAAGGATCGAGATCGAGACCGGGATCGTGAAGATCGGTCTAA
AGATCGAGACCGAGAACGTGATAGAGGAGATAGAGAGCGAGAGAGGGAGAAAGAAAAGGAGAAGGAGTTGCGAGCTTCAACAAATGCTAT
GCTTATCAGTGCTGGATTACCACCTTTGAAAGCTTCCCATTCAGCTCACTCAACCCACTCAGCACATTCAACGCATTCAACACATTCTGC
TCATTCAACGCATGCCGGACATGCAGGTCACACGTCACTTCCACAGTGCATTAATCCGTTCACCAACTTACCCCATACTCCTCGATACTA
TGATATTCTAAAGAAACGTCTTCAGCTCCCTGTTTGGGAATACAAGGATAGGTTTACAGATATTCTGGTTAGACATCAGTCCTTTGTACT
GGTTGGTGAGACTGGGTCTGGTAAAACAACACAGATTCCACAGTGGTGTGTGGAGTACATGCGATCATTACCAGGACCCAAGAGAGGAGT
TGCCTGTACCCAACCCAGGAGAGTGGCTGCAATGAGTGTGGCTCAGAGAGTTGCTGATGAGATGGATGTGATGTTGGGCCAGGAAGTTGG
TTACTCCATTCGATTTGAAGACTGCAGTAGTGCAAAAACCATTCTTAAGTATATGACTGATGGGATGTTACTTCGTGAAGCTATGAATGA
TCCCCTCCTGGAGCGTTATGGTGTAATAATTCTTGATGAGGCTCATGAGAGGACACTGGCTACAGATATTCTAATGGGTGTTCTGAAGGA
AGTTGTAAGACAGAGATCAGATTTAAAGGTTATAGTTATGAGCGCTACTCTAGATGCAGGAAAATTCCAGATTTACTTTGATAACTGTCC
TCTCCTAACTATTCCTGGGCGTACACATCCTGTTGAGATCTTCTATACTCCAGAACCAGAGAGAGATTATCTTGAAGCAGCAATTCGAAC
AGTTATCCAGATTCATATGTGTGAAGAGGAAGAGGGAGATCTTCTTCTTTTCTTAACTGGTCAAGAGGAAATTGATGAAGCCTGTAAGAG
AATAAAGCGTGAAGTTGATGATTTGGGCCCTGAAGTTGGTGACATTAAAATCATTCCATTGTATTCTACACTTCCACCTCAGCAGCAGCA
ACGCATTTTTGAGCCTCCACCTCCCAAAAAACAGAATGGAGCAATTGGAAGAAAGCTCTTGAGGATGACGATTGCCAAACAAAGGCTCGG
AGACGAAGCAATCGGCGTGCGACACTTTGCAGCCCATGAGCGTGAAGACTTGGTGCAGCAGCTAGAGCGAGCTAAGGAACAGATTGAGTC
TCTGGAGCACGACCTGCAGGCTTCTGTGGACGAGCTTCAGGATGTTAAAGAAGAACGGTCTTCCTACCAGGACAAAGTGGAGAGGCTCAA
CCAGGAGCTGAACCATATCCTGAGTGGGCACGAGAACCGCATCATTGACGTGGACGCCCTGTGTATGGAGAACAGGTACCTTCAAGAGAG
ATTAAAGCAACTCCATGAAGAGGTCAACCTCTTGAAATCAAACATTGCCAAATACAAGAATGCTCTGGAGAGACGGAAAAACTCGAAGGG
CCAGGGTAAATCCAGCAGCAGTGCTCTGACAGGAGTCCTGTCTGCAAAGCAAGTTCAGGATCTGCTATCTGAGGATCATGGATGCAGCCT
CCCAGCTACTCCGCAGTCCATTTCTGACCTGAAATCTCTGGCAACAGCCCTGTTGGAAACAATCCACGAGAAAAACATGGTCATTCAGCA
CCAGAGGCAAACCAACAAAATCCTAGGGAATCGGGTGGCTGAGCTGGAAAAAAAATTAAGAACTCTGGAAGTTTCTGGTTTGTGGAGTCT
TCCAGGGGGCAAGGACACCATACTGTTCAGCGACCCCACTCTTCCTAGTGGACAGAGGTCGAGATCCCCACTGCTGAAGTTTGTCGAGCA
GCCCACTGAGAACAAAGCAGATCCCAAGGATGGGGAGGCTCAGAAGCAAGAAGAAGATGAAAGTTGTGCCGCTGCTGAGGCGTTGACAGC
GCCTGAGGATGCTGGGAGGCCCGCTGTCAACTCCCCAGCAAATCAGAGCCGCGGGAACCAATGCAAGCTCTTTCATCCTTCATTACCCCA
GTTACCTTCTGAGGAAGAAGTAAACAGCCTTGGGAGGGAAATAATTAAACTGACAAAGGAACAGGCAGCTGCAGAACTGGAAGAGGTCAG
AAGAGAGAGTCCCATAGAAGGTCAGAGGAGTGAGACGGGGCCAGCCCCGCCAGGCCTGGCCATCCAGGGGGAGCTCCCTAAATCTCACCT
GGACTCCTTCGAGGCCAGCCGGCCAGCAGCCAAAGCTTCCACACCGGAAGACGGCAAAGGGATCCCAGAGGGCGGAGGCATGAGGAGCAC
CGTGAAAACCTGAAGGGGAGAGGGATCTGACACAATGACACATTGAAAGCCCCAGAGAGGGTCAAGAATGAAGCATCGGAATGGTGCGCT
CACGTCGCCTTCTCCTGAAATACCTCCGAGTCTGCAAGTGAGAAAACGCACTGATCCTGTTGCAAACTGTGAATATTCTGATGATGCCAG
TACAGTTTGATTTATTAAATGTAGGTCCTCAAGCTTCTCAGTGTCATCTCTTTTCTGCCAGAGAGTGCTACTGTGAACAGGGCCAGGCCC
AGGAATCGTGTCCACCATATGGCTGGTTTTCAGCATCCGTCTTTCTGTCAGCTTTTGTTTTATCAGAGATAAGATGTTTTTGTATTAGCA
TTTAATGTTGTCAATCAAAATTATGGGAAGAGCTAGAAACTGATGGGGTTTTTAATCAGGTCCCCATCTTGGTCAAGGTTAGGCAGCTGG
AGAGGAAGGTATAATTGAGCAAAACGTGTCCAGAGGACCCATGGCTGCACCCCATCAAGTCAGGGCCCAGGAGGACTGCCTGGCATGGGT
GTGCTTGGCATTGTGCCCACAGCACTGCTGTCGTGGTACAGACTGGCAGTTGGAAGGGGCCTTAAGCCGGCTGAGAAGTTTGGGCTTCTG
GGTTGAAATCCACAGCCCCGGTTGAGGCCTGTGTGCTGAGTGCCAGAGCTGGAGTTTTCTAGCTTGTAAATCTGGAGAATTAACTGATCT
GAAGTGACTGGGAGGGGTGAGCATAAAAGCCGGGGAACAGGACTCCCAGTGGTGGTCTGGTTTTTTTTGTGAGATGAGATGAGAGCTACC
ACCTGGAAATGCTCATTCTCTGCATTCAGCCTGTCTCACATACAGGATTGTATGGCCATTTCAGGTTTGGGAAAGATCTACCTGCTGGGA
GCCAGTCTAGTTTCCTGCACCACCTGGAACTTCCAAACCCTTCACTCCTTCAACAGAATGTTGAGGCTGCCTCATTTGTGCCACCAAGTA
CGGGAATCTTAAAGACAGAAACAGAGCTCATGACCTTTTATGGGAAAGAGAGAGGAAAACAAAACAACTTCACAACAGCATGGCAAGGGG
GGATGTGGAACCAAGGACATGATACAGGGATGGGAAAGGAGGGCATGCTCAATTCTAGCTGGTTCTTTCCTTTCAGATAAAAATGAGCTT
TTCTAGTTGGCATCCGGCACTGCAGAAAACTAAAAGTCATCCAGCCATAGCTTTTTCCTTCCCTGGAAAGCCTGAGACTAGATCCCAAAG
CTCAGAATGCCTCTGAGAACCAGAATCACTCCTTTGAGAGGCGCTCCTTGCAGGAAAAAGAGAGGCTCCCAGAGTGGTAGCCTCTCAGTG
AAAATGCATCCTAAAAATTCAATGTTTATACCAGGCTCATGACACTAAGATGTGACATCTGGACACGAGGGGTCAGCCACGTGGATACAT
CCCTCCCAGATTGCATCTCCAGGAATCACTCTGCTAGCAGAATGGGCGCCCCATCCCTTACTATGCTGCTCCTCCTCAAAGTGCAGCCCA
GAAGGACCCAGGCCTTTGATGCACATTGGGTGGGTCTCCCACTACTTTAGTTGAAATGGGAGCATGCTGGAGTCGGCGTTCTGTTGCTTC
TGGTGAGAAGGACATCCCATTGACCCCTGGCCACCAGGTCCAGTATTCCATCCTTCCTTCTGTCCCAGCCTATCGCCCTCCCCACCAGGC
CCACCCCCACAACTTCTCCTCAAGGGAGGTTGCTCCCGCAGCTGGAGGGCTTGCACAGACCAGCAGTCACAGAAATCATTCTTCCTGCTG
TACTGGGCCTTAACTGCCTGCAAATGTCCAGCACTACTGCATAGGATGCCAGAGCCACCGAAGGAAAACACAGCCAAGTTTAATAATAAT
AAAAGGAAAAATCTCAGCCTGCAGAACTCTGGTTTTGACCCACCATCGGCCAGATGCACATCTTCAGGGCCTGTTGAGCACCTTCTGAAA
AGCAGGGCTCGTAATAGACTCCAGCACATTCCATCAGAGTCAGGAAAACTGCAGTGAGTCCCAGAGAATCTAGGGTGCAGGGCAGGGAGC
AGGAGTCATAAGGAGTGATAACCTAAACTGTGTGTAGTCAGCGGGGAGGGTCTTATGTTATCAGGTGAAATGAGAGCCAGTAAGTTAGTT
GATCCTGTCACAGATATAACCCTGATAACACCCCATAGATACGCGACACGTGTGTCCTGCCCCTGCTTTCCCCATCCAACATGGTTCTTC

>22631_22631_1_DHX15-CCDC149_DHX15_chr4_24550478_ENST00000336812_CCDC149_chr4_24839894_ENST00000504487_length(amino acids)=841AA_BP=436
MCPYSSQLSSLITARSKSARMSKRHRLDLGEDYPSGKKRAGTDGKDRDRDRDREDRSKDRDRERDRGDREREREKEKEKELRASTNAMLI
SAGLPPLKASHSAHSTHSAHSTHSTHSAHSTHAGHAGHTSLPQCINPFTNLPHTPRYYDILKKRLQLPVWEYKDRFTDILVRHQSFVLVG
ETGSGKTTQIPQWCVEYMRSLPGPKRGVACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMNDPL
LERYGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVI
QIHMCEEEEGDLLLFLTGQEEIDEACKRIKREVDDLGPEVGDIKIIPLYSTLPPQQQQRIFEPPPPKKQNGAIGRKLLRMTIAKQRLGDE
AIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLK
QLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQR
QTNKILGNRVAELEKKLRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAAEALTAPE
DAGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRESPIEGQRSETGPAPPGLAIQGELPKSHLDS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DHX15-CCDC149

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for DHX15-CCDC149

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for DHX15-CCDC149

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source