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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DHX32-FAM160B1 (FusionGDB2 ID:22658)

Fusion Gene Summary for DHX32-FAM160B1

check button Fusion gene summary
Fusion gene informationFusion gene name: DHX32-FAM160B1
Fusion gene ID: 22658
HgeneTgene
Gene symbol

DHX32

FAM160B1

Gene ID

55760

57700

Gene nameDEAH-box helicase 32 (putative)family with sequence similarity 160 member B1
SynonymsDDX32|DHLP1KIAA1600|bA106M7.3
Cytomap

10q26.2

10q25.3

Type of geneprotein-codingprotein-coding
Descriptionputative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32DEAD/H box 32DEAD/H helicase-like protein-1DEAH (Asp-Glu-Ala-His) box polypeptide 32DEAH box protein 32huDDX32protein FAM160B1
Modification date2020031320200313
UniProtAcc

Q7L7V1

Q5W0V3

Ensembl transtripts involved in fusion geneENST00000284688, ENST00000284690, 
ENST00000368721, 		ENST00000369246, 
ENST00000369248, ENST00000369250, 
Fusion gene scores* DoF score3 X 4 X 2=247 X 7 X 3=147
# samples 47
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DHX32 [Title/Abstract] AND FAM160B1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDHX32(127540862)-FAM160B1(116590611), # samples:1
Anticipated loss of major functional domain due to fusion event.DHX32-FAM160B1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DHX32 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAM160B1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-IN-7808-01ADHX32chr10

127540862

-FAM160B1chr10

116590611

+


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Fusion Gene ORF analysis for DHX32-FAM160B1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000284688ENST00000369246DHX32chr10

127540862

-FAM160B1chr10

116590611

+
Frame-shiftENST00000284688ENST00000369248DHX32chr10

127540862

-FAM160B1chr10

116590611

+
Frame-shiftENST00000284688ENST00000369250DHX32chr10

127540862

-FAM160B1chr10

116590611

+
Frame-shiftENST00000284690ENST00000369246DHX32chr10

127540862

-FAM160B1chr10

116590611

+
Frame-shiftENST00000284690ENST00000369248DHX32chr10

127540862

-FAM160B1chr10

116590611

+
Frame-shiftENST00000284690ENST00000369250DHX32chr10

127540862

-FAM160B1chr10

116590611

+
In-frameENST00000368721ENST00000369246DHX32chr10

127540862

-FAM160B1chr10

116590611

+
In-frameENST00000368721ENST00000369248DHX32chr10

127540862

-FAM160B1chr10

116590611

+
In-frameENST00000368721ENST00000369250DHX32chr10

127540862

-FAM160B1chr10

116590611

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000368721DHX32chr10127540862-ENST00000369250FAM160B1chr10116590611+3648115812783329683
ENST00000368721DHX32chr10127540862-ENST00000369248FAM160B1chr10116590611+6584115812783410710
ENST00000368721DHX32chr10127540862-ENST00000369246FAM160B1chr10116590611+147011587191240173

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368721ENST00000369250DHX32chr10127540862-FAM160B1chr10116590611+0.000989850.9990101
ENST00000368721ENST00000369248DHX32chr10127540862-FAM160B1chr10116590611+0.0002664470.9997335
ENST00000368721ENST00000369246DHX32chr10127540862-FAM160B1chr10116590611+0.283705530.7162945

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Fusion Genomic Features for DHX32-FAM160B1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DHX32chr10127540861-FAM160B1chr10116590610+0.0008512280.9991487
DHX32chr10127540861-FAM160B1chr10116590610+0.0008512280.9991487

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DHX32-FAM160B1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:127540862/chr10:116590611)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DHX32

Q7L7V1

FAM160B1

Q5W0V3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDHX32chr10:127540862chr10:116590611ENST00000284688-51072_238369663.0DomainHelicase ATP-binding
HgeneDHX32chr10:127540862chr10:116590611ENST00000284690-61172_238450744.0DomainHelicase ATP-binding
HgeneDHX32chr10:127540862chr10:116590611ENST00000284688-510185_188369663.0MotifNote=DEAH box
HgeneDHX32chr10:127540862chr10:116590611ENST00000284690-611185_188450744.0MotifNote=DEAH box
HgeneDHX32chr10:127540862chr10:116590611ENST00000284688-51085_92369663.0Nucleotide bindingATP
HgeneDHX32chr10:127540862chr10:116590611ENST00000284690-61185_92450744.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DHX32-FAM160B1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22658_22658_1_DHX32-FAM160B1_DHX32_chr10_127540862_ENST00000368721_FAM160B1_chr10_116590611_ENST00000369246_length(transcript)=1470nt_BP=1158nt
GTTCTCATTATTCCAATTGGCAAGTTTTCACTCATTAGGATCAACAGCCATGCTGTTTGCTTGGTAAAAAATCTGCCCCAAGTAATTCAA
TTATATGTGGAAAAAGGAAGTGCAAGCAAGGGACCGTACCTGTGTACCAGCTGATGTGGGACCCCCTGGAGCGGCCTCTGCCCAGCTTCC
TGGGAGCCACTTAGCAGACCAGGAAACGAGCACAGCTCACCTAGTTCTCAGTGACCTGTGATACCTTGCTATTTTTCTAGATGGATCTGT
CTTCCTACAAAACCCTTGAGTTAATTCAATCCCATTCTACAAATGGTATGGAAAGGAAAGAGACATAAGCTAGAGACCTAGAGAATGGAA
TTGAGCTGTAAAAACTATGGCAGTTGTGGGAAGTCATCTTTTTTACTTAGATTTTTAGTGAAATCTAACAAAATTAAATGGGAAAACAAT
ATAAATTATATTTAACTTCCCCAAAGACGTTTTCTCATTTAGGTGCATCTTTACTTATTTAAAGATACATGTAGGCAGCAACACAGGGAT
TTCTTTCCCTGTATCTGTTACGTAGTATTGCCTAAAATTTTTTGTAATTCAGACATTTTTTTAATAGTGATGTTGTTTGCATTGTATTTT
ATTTTCATGGGTTTTTTTTTCTTTAGGATATTGAGAAAGTCTGTGAAACTGTCTATCAAGGATCTAACCTAAACCCAGATCTTGGAGAAC
TGGTGGTTGTTCCTTTGTATCCAAAAGAGAAATGTTCATTGTTCAAGCCACTCGATGAAACAGAAAAAAGATGCCAAGTTTATCAAAGAA
GAGTGGTGTTAACTACTAGCTCTGGAGAGTTTTTGATCTGGAGCAACTCAGTCAGATTTGTTATCGATGTGGGTGTGGAAAGAAGAAAGG
TGTACAACCCGAGAATAAGAGCAAACTCGCTCGTCATGCAGCCCATCAGCCAGAGCCAGGCAGAGATACGCAAGCAGATTCTTGGCTCAT
CTTCTTCAGGAAAATTTTTCTGCCTGTACACTGAAGAATTTGCCTCCAAAGACATGACGCCACTGAAGCCAGCAGAAATGCAGGAAGCCA
ACCTAACAAGCATGGTGCTTTTTATGAAGAGGATAGACATTGCGGGCCTAGGCCACTGTGACTTCATGAACAGACCAGCTTGCACCTTCT
CTTCCTTTACAAGAAGATTTTGTTTATCACTGGAAGGCAATTACCCATTACTACATAGAGACTTCAGATGATAAAGCCCCAGTGACCGAT
ACAAATATTCCATCGCATCTGGAACAGATGTTAGATATACTGGTTCAAGAAGAAAATGAACGGGAATCTGGAGAGACAGGGCCATGTATG
GAATATTTGCTTCATCACAAGATCTTGGAAACATTATATACCTTGGGGAAAGCTGATGTAAGTTCCTGATCCACACCATGTTCTTGGGCA

>22658_22658_1_DHX32-FAM160B1_DHX32_chr10_127540862_ENST00000368721_FAM160B1_chr10_116590611_ENST00000369246_length(amino acids)=173AA_BP=146
MVVVPLYPKEKCSLFKPLDETEKRCQVYQRRVVLTTSSGEFLIWSNSVRFVIDVGVERRKVYNPRIRANSLVMQPISQSQAEIRKQILGS

--------------------------------------------------------------
>22658_22658_2_DHX32-FAM160B1_DHX32_chr10_127540862_ENST00000368721_FAM160B1_chr10_116590611_ENST00000369248_length(transcript)=6584nt_BP=1158nt
GTTCTCATTATTCCAATTGGCAAGTTTTCACTCATTAGGATCAACAGCCATGCTGTTTGCTTGGTAAAAAATCTGCCCCAAGTAATTCAA
TTATATGTGGAAAAAGGAAGTGCAAGCAAGGGACCGTACCTGTGTACCAGCTGATGTGGGACCCCCTGGAGCGGCCTCTGCCCAGCTTCC
TGGGAGCCACTTAGCAGACCAGGAAACGAGCACAGCTCACCTAGTTCTCAGTGACCTGTGATACCTTGCTATTTTTCTAGATGGATCTGT
CTTCCTACAAAACCCTTGAGTTAATTCAATCCCATTCTACAAATGGTATGGAAAGGAAAGAGACATAAGCTAGAGACCTAGAGAATGGAA
TTGAGCTGTAAAAACTATGGCAGTTGTGGGAAGTCATCTTTTTTACTTAGATTTTTAGTGAAATCTAACAAAATTAAATGGGAAAACAAT
ATAAATTATATTTAACTTCCCCAAAGACGTTTTCTCATTTAGGTGCATCTTTACTTATTTAAAGATACATGTAGGCAGCAACACAGGGAT
TTCTTTCCCTGTATCTGTTACGTAGTATTGCCTAAAATTTTTTGTAATTCAGACATTTTTTTAATAGTGATGTTGTTTGCATTGTATTTT
ATTTTCATGGGTTTTTTTTTCTTTAGGATATTGAGAAAGTCTGTGAAACTGTCTATCAAGGATCTAACCTAAACCCAGATCTTGGAGAAC
TGGTGGTTGTTCCTTTGTATCCAAAAGAGAAATGTTCATTGTTCAAGCCACTCGATGAAACAGAAAAAAGATGCCAAGTTTATCAAAGAA
GAGTGGTGTTAACTACTAGCTCTGGAGAGTTTTTGATCTGGAGCAACTCAGTCAGATTTGTTATCGATGTGGGTGTGGAAAGAAGAAAGG
TGTACAACCCGAGAATAAGAGCAAACTCGCTCGTCATGCAGCCCATCAGCCAGAGCCAGGCAGAGATACGCAAGCAGATTCTTGGCTCAT
CTTCTTCAGGAAAATTTTTCTGCCTGTACACTGAAGAATTTGCCTCCAAAGACATGACGCCACTGAAGCCAGCAGAAATGCAGGAAGCCA
ACCTAACAAGCATGGTGCTTTTTATGAAGAGGATAGACATTGCGGGCCTAGGCCACTGTGACTTCATGAACAGACCAGCTTGCACCTTCT
CTTCCTTTACAAGAAGATTTTGTTTATCACTGGAAGGCAATTACCCATTACTACATAGAGACTTCAGATGATAAAGCCCCAGTGACCGAT
ACAAATATTCCATCGCATCTGGAACAGATGTTAGATATACTGGTTCAAGAAGAAAATGAACGGGAATCTGGAGAGACAGGGCCATGTATG
GAATATTTGCTTCATCACAAGATCTTGGAAACATTATATACCTTGGGGAAAGCTGATTGTCCTCCGGGAATGAAACAGCAGGTTTTGGTT
TTCTATACGAAACTTCTGGGAAGAATCCGGCAGCCACTACTTCCACACATTAACGTGCACAGGCCAGTGCAGAAATTAATTAGACTCTGT
GGTGAAGTCCTAGCAACACCAACAGAAAATGAAGAGATTCAGTTTCTTTGCATTGTGTGTGCGAAGCTGAAACAGGACCCCTACCTGGTT
AACTTTTTCCTAGAGAATAAGATGAAATCATTGGCTTCCAAAGGAGTACCAAATGTAATTTCAGAAGATACATTAAAAGGTCAGGATTCC
TTGTCAACAGATACAGGACAGTCCCGTCAACCAGAGGAACTATCTGGTGCTACTGGAATGGAGCAAACAGAATTGGAAGATGAGCCTCCT
CATCAGATGGATCACCTGTCCACAAGCTTGGATAACCTCAGTGTCACCTCACTGCCAGAGGCCTCGGTTGTTTGTCCAAATCAGGATTAC
AATTTAGTGAATTCTTTGTTAAATCTTACTAGAAGTCCTGATGGCAGAATAGCTGTGAAGGCATGTGAAGGCTTGATGCTGTTAGTAAGT
TTGCCAGAGCCTGCGGCTGCAAAGTGCCTTACACAGAGCACTTGCTTGTGTGAACTACTGACAGACAGACTTGCCTCCCTGTACAAGGCC
CTACCTCAGTCAGTGGATCCGTTAGATATTGAAACCGTGGAAGCAATTAACTGGGGCTTGGACTCATATAGTCATAAAGAAGATGCTTCA
GCATTTCCAGGAAAACGAGCCTTAATTTCATTTCTTTCCTGGTTTGATTATTGTGATCAGCTCATTAAGGAAGCCCAAAAGACTGCTGCT
GTTGCTCTTGCCAAAGCTGTTCATGAAAGATTTTTCATTGGTGTTATGGAACCTCAATTAATGCAAACTTCTGAGATGGGTATTCTCACA
TCCACTGCTCTGCTTCATCGCATCGTTCGGCAAGTGACCTCTGATGTTTTGCTTCAAGAAATGGTGTTTTTTATCCTTGGAGAACAGAGG
GAACCAGAAACTCTGGCAGAAATCAGCAGACATCCTTTAAGGCATAGGTTAATTGAACATTGTGATCACATATCTGATGAGATAAGCATA
ATGACATTACGAATGTTTGAACATCTTTTACAAAAACCCAATGAGCACATTCTTTACAACTTGGTCTTGAGAAATCTTGAAGAAAGAAAT
TATACAGAATATAAACCTTTGTGCCCAGAAGATAAAGATGTGGTAGAAAATGGATTGATAGCAGGAGCAGTAGATCTGGAAGAAGATCCA
TTATTTACTGACATTTCACCAGAAAACACTTTGCCAAACCAAGAGTGGCTTAGTTCTTCACCTCCTGCTACTCCAGACCACCCCAAAAAT
GATGGAAAAACTGAAGTTCATAAAATTGTAAATAGTTTTCTCTGTCTGGTACCGGATGACGCAAAATCCTCCTACCATGTTGAGGGCACA
GGATATGACACTTACCTCCGAGACGCTCATAGGCAGTTCCGAGACTACTGTGCTATCTGCTTAAGATGGGAGTGGCCTGGGTCTCCAAAA
GCATTGGAAAAGTGCAATTTAGAAGCTGCTTTCTTTGAAGGTCATTTTTTGAAAGTGCTGTTCGACAGAATGGGAAGAATTCTTGATCAG
CCATATGATGTAAACTTACAAGTAACCTCAGTGTTATCTAGACTTTCTCTCTTCCCTCATCCACACATCCACGAGTACCTTTTGGATCCT
TACGTGAACCTCGCTCCTGGCTGTAGATCTCTCTTCTCTGTAATTGTCAGGGTTGTTGGAGACCTTATGCTTCGAATCCAGCGTATTCAA
GACTTTACTCCCAAGCTTCTGTTAGTCAGAAAGCGGTTACTTGGTTTGGAACCTGAAGGCCCTATTATTGACCACATCACACTGCTAGAG
GGTGTGATTGTGTTAGAAGAGTTCTGTAAGGAGCTGGCGGCAATCGCATTTGTAAAATATCATGCTTCCTCCACACCATAAATAACATCT
TTCATGTAACTGGGGGAACAGAACTACTGTGTACATTTCACCAAAAAAGACTCAGTTCCACCCAGCCACAAGAGGATAAAAAGCCTTTTT
AAACGCAGTATTGCTGTAAACTGGACAGAACCATTAAGAACCTATTGAGTGGACATTCTTGGTGAAATGTTGTATAATGTTGTTTTCATT
GGCTTTATCATAATGGTTCTATATATACAATTGCACATTGTTGAATCCAGGATACAATCAAAGGAACTTCAGGAAATAAGCATTTCTAAT
GACTGTGAAAAGCTGCAATATTTCCAATGTCATGACTTTGATGATATTTCTGTTATATTAATGTCCTTTTAGGTAGCAAGGCATTTTGAC
ATTCTCTGGGACTCAAATGCTTGTATTCTTTTGGATTAATAAGTAGCAAAAAAAAATCACTAATTTTATAACTTTTTAAGGTCAGAATTC
TTATCAAACAAAATATGAAAACTGTAAATGAGAAAAAAATACAATTCAGAAACCATTGAATGAATTAATTATAGGCGATAAAAATGTGTA
GAGCACCATTAACTTTCTTCAGCTTTTTTAAGAATAACAATTTAATATGATAAATTCTTGATTAATATAATATATCTATATTTTTAAAGA
AATGTTCTTTTACTCTTTTGTGCACATAGCCATGTTAGTGATTTTCTTCATGTGTGGGTCCCAGTTTATTTAAACTGTGTCGTTTTCGCA
GCAGTGTTCAATTTGCTCACCATTGGTAGTGTTTGCTAAAATTGTATTTTTTTAAGCTAAGTAACATGTACTGGGTTGAGAACCTTTTTC
CCCCCTCTCCCTCTCAGAAAATTGCTTTATAAAATTGCTTTATAATTTGATTTTCTTACTGAAACGCATGGTGGTGTCTAGGTGGGGAAC
TGACTGATAACCCTTGGCAGCAATCAAAGTGCCAGTGGCTCCTCGATGTTTACATTTTTTTCTATTTTGTTCAGTCTTTTGTTTTAAATG
ATTCTAAAGAGATTAAAGAAAACAGAGTTTTAAATGTCCTATTTACATGTTAAAGGATTTGGGGAAATTGGGTATGTATGTGAATGGGTG
TACATGTAGGAACCTGTAGTTCAGCAAAGCTGCGCTGGGCACAGCATGCTTGTACTTGATTGACAAAATCGTGTTTGCCAGTCCACTTTC
TATTTTTCCTTTAAGTGATGCTGATCACTCAAATAATGCTTTTAAGCTATTGTTTGTTTTTATTTGACATGTTAAGCCGCAGCACTTTCT
TCTTCATCTTTCCATTTACTGATATTTGGGGGAACAGGCTATCAAAGGTTCCGGCTTGAAGGGAACTGTCACTACCCCCTCTAGGAAGTT
ATTTTATGTAGCATGTTTGCATATACGCATTGTGTGGCATGTGCATAGAGGCTTGTTTTACACCTATCTGCTCATTTTGTTGTGTTAGCT
TTTCTGGTTTATTTCATAGTTTGTTCTTGCTATTTATTAAGAACAGAATATCAAAAGATTATGAATAGCCTCAGCTCTAGAATGCTTACC
ACTGTTAAAACAACAAAAAGACTAAACCTCTAATTTCATGCAAATCTTTGTTAGCTTATTCTAAGAAATTTATTAAGTAAAACAAAGAAA
AAACAGAAGTGGGAGATAGTTATTTTGTGCGTAATTTTCTTTAAATCATTTTGAATGATGTGAAGGCATTCAGTTTGCTGTATTTTTTTA
ATCACTTCATACAAGGAAAACTTCGACATTTACATTTCTAGATGTAGTAACAGTCTACTTTGATATATGAGTATTTAAACTAAGGCATTA
AGAGATATTAGATATTTCTTAATGTTTTCATAGTGCTCAATAGGTGTAGTAGCAATGATATTACCTCTGAAACCAAATACTCTTTTATCC
TTGATTCCACTATGGGACCTTATAACTAGTCCATGAAACCAAGCTCAGAAAAGCTTTAACTCTTATATTTGTGTATATGTATGCTGCTTC
TGAAAATATAATTTTTCTAAGTTGTTGTAATGACTTTAATTTGTAATCAGCTAAGGCTTAAGATTTCATTTGTTTCTAAGTTTCTGTTTT
TCATCCCTTCTTTTTTCTTTTATATTTAGTTCAGACCTAGAGCCAGTAGAAGCTCTCACAGTGAGTTCAATTTGTTAGTGAAACATTGTA
CTGCATCACCAGTTTTTCTTACCTTCTGTTGACAGCTGAATATTTCTGTTACTCAGTACTTGCAAAAACAGTAACTAAAATGCACTATGC
TGAGTGGAAAGCACCGTCATAACAATTGATTGCCATAGCAAGTTCCAAAGTGAATTTCAGCCTTGCTTCACATTTGTATCAATAAATATG
CACATTTTTTAAAACTTTCTAACAATATAGTCTTTGGATTTGTTTTTAGTTATGAGCCGCATTCTTTACTTGATAGAACTCAGATTTGTC
TTAGCCTATTGCCATATAGTACTCACCTTATAACTATGTAACTTTCTCGTAATGTATCTGTTTGTGCAATATGGAAGCTGTGAGTGGATT
CATAGCTTTTTGGTTTAATTGTACATTATTGTGTGTGTATATATGTATATATGTATATATATAAGGACCAAAATTCTTAGCTCGCTTACA
CTGTTGCTAGTGTAAACATTGTTACACTTAATTTTACAGGGCACAAATTATGGAATTACTTCATAAATTCATGGTAATGTTTTCATAAAT
TATTGCATTAACATACAATTGCCATTTAATTATGAAGTCCATCAGTATTGACAGAAGACGTTACAGTGAAGTGCTAAAACCACACTATAT
GGTAATTATATTTTGGGTTATGTAGTAAATCAAATATGCATGTCATTGTGACACTTTATGTGTTAAAACATGGTAGATAATCACATTTTC
TGGGCCCTGTAAAATAGTGTTACTGTAATACTCTGTTTTGCCTCCTGCCTTGTTTACATTAAACAGGATATTTGGTAAATTTTTTTGTAT
TGAAAGTTGTGTAGGTTACTGACAGTGTTACCAGCGTCTGGAATTCTTGGTCCCTCCGTGGAGAAACTCTTCAGATGGTCATTGTGTACC
TACTCTCTCTTCAAAGGAAGTTGTGATCAAGTTCAACTTTTTGTGCTAACAATGCATGCAGGACTAAGAGGGATGATCTAAAAAATAAAT

>22658_22658_2_DHX32-FAM160B1_DHX32_chr10_127540862_ENST00000368721_FAM160B1_chr10_116590611_ENST00000369248_length(amino acids)=710AA_BP=
MEQMLDILVQEENERESGETGPCMEYLLHHKILETLYTLGKADCPPGMKQQVLVFYTKLLGRIRQPLLPHINVHRPVQKLIRLCGEVLAT
PTENEEIQFLCIVCAKLKQDPYLVNFFLENKMKSLASKGVPNVISEDTLKGQDSLSTDTGQSRQPEELSGATGMEQTELEDEPPHQMDHL
STSLDNLSVTSLPEASVVCPNQDYNLVNSLLNLTRSPDGRIAVKACEGLMLLVSLPEPAAAKCLTQSTCLCELLTDRLASLYKALPQSVD
PLDIETVEAINWGLDSYSHKEDASAFPGKRALISFLSWFDYCDQLIKEAQKTAAVALAKAVHERFFIGVMEPQLMQTSEMGILTSTALLH
RIVRQVTSDVLLQEMVFFILGEQREPETLAEISRHPLRHRLIEHCDHISDEISIMTLRMFEHLLQKPNEHILYNLVLRNLEERNYTEYKP
LCPEDKDVVENGLIAGAVDLEEDPLFTDISPENTLPNQEWLSSSPPATPDHPKNDGKTEVHKIVNSFLCLVPDDAKSSYHVEGTGYDTYL
RDAHRQFRDYCAICLRWEWPGSPKALEKCNLEAAFFEGHFLKVLFDRMGRILDQPYDVNLQVTSVLSRLSLFPHPHIHEYLLDPYVNLAP

--------------------------------------------------------------
>22658_22658_3_DHX32-FAM160B1_DHX32_chr10_127540862_ENST00000368721_FAM160B1_chr10_116590611_ENST00000369250_length(transcript)=3648nt_BP=1158nt
GTTCTCATTATTCCAATTGGCAAGTTTTCACTCATTAGGATCAACAGCCATGCTGTTTGCTTGGTAAAAAATCTGCCCCAAGTAATTCAA
TTATATGTGGAAAAAGGAAGTGCAAGCAAGGGACCGTACCTGTGTACCAGCTGATGTGGGACCCCCTGGAGCGGCCTCTGCCCAGCTTCC
TGGGAGCCACTTAGCAGACCAGGAAACGAGCACAGCTCACCTAGTTCTCAGTGACCTGTGATACCTTGCTATTTTTCTAGATGGATCTGT
CTTCCTACAAAACCCTTGAGTTAATTCAATCCCATTCTACAAATGGTATGGAAAGGAAAGAGACATAAGCTAGAGACCTAGAGAATGGAA
TTGAGCTGTAAAAACTATGGCAGTTGTGGGAAGTCATCTTTTTTACTTAGATTTTTAGTGAAATCTAACAAAATTAAATGGGAAAACAAT
ATAAATTATATTTAACTTCCCCAAAGACGTTTTCTCATTTAGGTGCATCTTTACTTATTTAAAGATACATGTAGGCAGCAACACAGGGAT
TTCTTTCCCTGTATCTGTTACGTAGTATTGCCTAAAATTTTTTGTAATTCAGACATTTTTTTAATAGTGATGTTGTTTGCATTGTATTTT
ATTTTCATGGGTTTTTTTTTCTTTAGGATATTGAGAAAGTCTGTGAAACTGTCTATCAAGGATCTAACCTAAACCCAGATCTTGGAGAAC
TGGTGGTTGTTCCTTTGTATCCAAAAGAGAAATGTTCATTGTTCAAGCCACTCGATGAAACAGAAAAAAGATGCCAAGTTTATCAAAGAA
GAGTGGTGTTAACTACTAGCTCTGGAGAGTTTTTGATCTGGAGCAACTCAGTCAGATTTGTTATCGATGTGGGTGTGGAAAGAAGAAAGG
TGTACAACCCGAGAATAAGAGCAAACTCGCTCGTCATGCAGCCCATCAGCCAGAGCCAGGCAGAGATACGCAAGCAGATTCTTGGCTCAT
CTTCTTCAGGAAAATTTTTCTGCCTGTACACTGAAGAATTTGCCTCCAAAGACATGACGCCACTGAAGCCAGCAGAAATGCAGGAAGCCA
ACCTAACAAGCATGGTGCTTTTTATGAAGAGGATAGACATTGCGGGCCTAGGCCACTGTGACTTCATGAACAGACCAGCTTGCACCTTCT
CTTCCTTTACAAGAAGATTTTGTTTATCACTGGAAGGCAATTACCCATTACTACATAGAGACTTCAGATGATAAAGCCCCAGTGACCGAT
ACAAATATTCCATCGCATCTGGAACAGATGTTAGATATACTGGTTCAAGAAGAAAATGAACGGGAATCTGGAGAGACAGGGCCATGTATG
GAATATTTGCTTCATCACAAGATCTTGGAAACATTATATACCTTGGGGAAAGCTGATTGTCCTCCGGGAATGAAACAGCAGGTTTTGGTT
TTCTATACGAAACTTCTGGGAAGAATCCGGCAGCCACTACTTCCACACATTAACGTGCACAGGCCAGTGCAGAAATTAATTAGACTCTGT
GGTGAAGTCCTAGCAACACCAACAGAAAATGAAGAGATTCAGTTTCTTTGCATTGTGTGTGCGAAGCTGAAACAGGACCCCTACCTGGTT
AACTTTTTCCTAGAGAATAAGATGAAATCATTGGCTTCCAAAGGAGTACCAAATGTAATTTCAGAAGATACATTAAAAGGTCAGGATTCC
TTGTCAACAGATACAGGACAGTCCCGTCAACCAGAGGAACTATCTGGTGCTACTGGAATGGAGCAAACAGAATTGGAAGATGAGCCTCCT
CATCAGATGGATCACCTGTCCACAAGCTTGGATAACCTCAGTGTCACCTCACTGCCAGAGGCCTCGGTTGTTTGTCCAAATCAGGATTAC
AATTTAGTGAATTCTTTGTTAAATCTTACTAGAAGTCCTGATGGCAGAATAGCTGTGAAGGCATGTGAAGGCTTGATGCTGTTAGTAAGT
TTGCCAGAGCCTGCGGCTGCAAAGTGCCTTACACAGAGCACTTGCTTGTGTGAACTACTGACAGACAGACTTGCCTCCCTGTACAAGGCC
CTACCTCAGTCAGTGGATCCGTTAGATATTGAAACCGTGGAAGCAATTAACTGGGGCTTGGACTCATATAGTCATAAAGAAGATGCTTCA
GCATTTCCAGGAAAACGAGCCTTAATTTCATTTCTTTCCTGGTTTGATTATTGTGATCAGCTCATTAAGGAAGCCCAAAAGACTGCTGCT
GTTGCTCTTGCCAAAGCTGTTCATGAAAGATTTTTCATTGGTGTTATGGAACCTCAATTAATGCAAACTTCTGAGATGGGTATTCTCACA
TCCACTGCTCTGCTTCATCGCATCGTTCGGCAAGTGACCTCTGATGTTTTGCTTCAAGAAATGGTGTTTTTTATCCTTGGAGAACAGAGG
GAACCAGAAACTCTGGCAGAAATCAGCAGACATCCTTTAAGGCATAGGTTAATTGAACATTGTGATCACATATCTGATGAGATAAGCATA
ATGACATTACGAATGTTTGAACATCTTTTACAAAAACCCAATGAGCACATTCTTTACAACTTGGTCTTGAGAAATCTTGAAGAAAGAAAT
TATACAGAATATAAACCTTTGTGCCCAGAAGATAAAGATGTGGTAGAAAATGGATTGATAGCAGGAGCAGTAGATCTGGAAGAAGATCCA
TTATTTACTGACATTTCACCAGAAAACACTTTGCCAAACCAAGAGTGGCTTAGTTCTTCACCTCCTGCTACTCCAGACCACCCCAAAAAT
GATGGAAAAACTGAAGTTCATAAAATTGTAAATAGTTTTCTCTGTCTGGTACCGGATGACGCAAAATCCTCCTACCATGTTGAGGGCACA
GGATATGACACTTACCTCCGAGACGCTCATAGGCAGTTCCGAGACTACTGTGCTATCTGCTTAAGATGGGAGTGGCCTGGGTCTCCAAAA
GCATTGGAAAAGTGCAATTTAGAAGCTGCTTTCTTTGAAGGTCATTTTTTGAAAGTGCTGTTCGACAGAATGGGAAGAATTCTTGATCAG
CCATATGATGTAAACTTACAAGTAACCTCAGTGTTATCTAGACTTTCTCTCTTCCCTCATCCACACATCCACGAGTACCTTTTGGATCCT
TACGTGAACCTCGCTCCTGGCTGTAGATCTCTCTTCTCTGTAATTGTCAGGGTTGTTGGAGACCTTATGCTTCGAATCCAGCGTATTCAA
GACTTTACTCCCAAGCTTCTGTTAGTCAGAAAGCGGTTACTTGGTTTGGAACCTGAAGGCCCTATGCAGACGTTGCCTTCATGGTGGTAA
GAGGGATTCCAGAGTCTCTTATGTCCTCAAAGCTTCAAGCTCAGCCAAAAGAATCTCGATGGTTTCCACAAAAAATCTTGGGCCTTGGAT
CAACTGCCCACCCTTGAACCAATCCTGGTGGCCCCAGGCTGATTGGCAGACCTGAATCACCTATCCCATGCCCAGAACTTTGGCTTGACC
AGGCTCATCCAAAACAAGGGAATCCAGAGTGTTTCCCCAAAGAAAATCAGGGGGCTATTACTGGGAAAAAGAATTCCACCACAAGTATAA

>22658_22658_3_DHX32-FAM160B1_DHX32_chr10_127540862_ENST00000368721_FAM160B1_chr10_116590611_ENST00000369250_length(amino acids)=683AA_BP=
MEQMLDILVQEENERESGETGPCMEYLLHHKILETLYTLGKADCPPGMKQQVLVFYTKLLGRIRQPLLPHINVHRPVQKLIRLCGEVLAT
PTENEEIQFLCIVCAKLKQDPYLVNFFLENKMKSLASKGVPNVISEDTLKGQDSLSTDTGQSRQPEELSGATGMEQTELEDEPPHQMDHL
STSLDNLSVTSLPEASVVCPNQDYNLVNSLLNLTRSPDGRIAVKACEGLMLLVSLPEPAAAKCLTQSTCLCELLTDRLASLYKALPQSVD
PLDIETVEAINWGLDSYSHKEDASAFPGKRALISFLSWFDYCDQLIKEAQKTAAVALAKAVHERFFIGVMEPQLMQTSEMGILTSTALLH
RIVRQVTSDVLLQEMVFFILGEQREPETLAEISRHPLRHRLIEHCDHISDEISIMTLRMFEHLLQKPNEHILYNLVLRNLEERNYTEYKP
LCPEDKDVVENGLIAGAVDLEEDPLFTDISPENTLPNQEWLSSSPPATPDHPKNDGKTEVHKIVNSFLCLVPDDAKSSYHVEGTGYDTYL
RDAHRQFRDYCAICLRWEWPGSPKALEKCNLEAAFFEGHFLKVLFDRMGRILDQPYDVNLQVTSVLSRLSLFPHPHIHEYLLDPYVNLAP

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Fusion Gene PPI Analysis for DHX32-FAM160B1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DHX32-FAM160B1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DHX32-FAM160B1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource