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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DHX34-ARHGAP35 (FusionGDB2 ID:22665)

Fusion Gene Summary for DHX34-ARHGAP35

Fusion gene summary

Fusion gene information	Fusion gene name: DHX34-ARHGAP35
	Fusion gene ID: 22665
		Hgene	Tgene
	Gene symbol	DHX34	ARHGAP35
	Gene ID	9704	2909
	Gene name	DExH-box helicase 34	Rho GTPase activating protein 35
	Synonyms	DDX34\|HRH1	GRF-1\|GRLF1\|P190-A\|P190A\|p190ARhoGAP\|p190RhoGAP
	Cytomap	19q13.32	19q13.32
	Type of gene	protein-coding	protein-coding
	Description	probable ATP-dependent RNA helicase DHX34DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 34DEAH (Asp-Glu-Ala-His) box polypeptide 34DEAH box protein 34DEAH-box helicase 34probable ATP-dependent helicase DHX34	rho GTPase-activating protein 35glucocorticoid receptor DNA-binding factor 1glucocorticoid receptor repression factor 1rho GAP p190A
	Modification date	20200322	20200313
	UniProtAcc	Q14147	Q9NRY4
	Ensembl transtripts involved in fusion gene	ENST00000471451, ENST00000328771,	ENST00000404338, ENST00000598548,
Fusion gene scores	* DoF score	5 X 5 X 4=100	14 X 8 X 8=896
	# samples	5	14
	** MAII score	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/896*10)=-2.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DHX34 [Title/Abstract] AND ARHGAP35 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DHX34(47863327)-ARHGAP35(47491246), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across DHX34 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ARHGAP35 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-39-5034-01A	DHX34	chr19	47863327	+	ARHGAP35	chr19	47491246	+

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Fusion Gene ORF analysis for DHX34-ARHGAP35

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000471451	ENST00000404338	DHX34	chr19	47863327	+	ARHGAP35	chr19	47491246	+
3UTR-intron	ENST00000471451	ENST00000598548	DHX34	chr19	47863327	+	ARHGAP35	chr19	47491246	+
5CDS-intron	ENST00000328771	ENST00000598548	DHX34	chr19	47863327	+	ARHGAP35	chr19	47491246	+
In-frame	ENST00000328771	ENST00000404338	DHX34	chr19	47863327	+	ARHGAP35	chr19	47491246	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000328771

DHX34

chr19

47863327

ENST00000404338

ARHGAP35

chr19

47491246

6787

1724

322

2397

691

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000328771	ENST00000404338	DHX34	chr19	47863327	+	ARHGAP35	chr19	47491246	+	0.001922841	0.99807715

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Fusion Genomic Features for DHX34-ARHGAP35

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
DHX34	chr19	47863327	+	ARHGAP35	chr19	47491245	+	8.06E-09	1
DHX34	chr19	47863327	+	ARHGAP35	chr19	47491245	+	8.06E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DHX34-ARHGAP35

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:47863327/chr19:47491246)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DHX34 Q14147	ARHGAP35 Q9NRY4
FUNCTION: Probable ATP-binding RNA helicase.	FUNCTION: Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250\|UniProtKB:P81128, ECO:0000250\|UniProtKB:Q91YM2, ECO:0000269\|PubMed:1894621, ECO:0000269\|PubMed:19673492, ECO:0000269\|PubMed:28894085}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DHX34

chr19:47863327

chr19:47491246

ENST00000328771

172_332

458

1144.0

Domain

Helicase ATP-binding

Hgene

DHX34

chr19:47863327

chr19:47491246

ENST00000328771

279_282

458

1144.0

Motif

Note=DEAH box

Hgene

DHX34

chr19:47863327

chr19:47491246

ENST00000328771

185_192

458

1144.0

Nucleotide binding

ATP

Tgene

ARHGAP35

chr19:47863327

chr19:47491246

ENST00000404338

1440_1490

1275

1500.0

Compositional bias

Note=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DHX34

chr19:47863327

chr19:47491246

ENST00000328771

368_536

458

1144.0

Domain

Helicase C-terminal

Tgene

ARHGAP35

chr19:47863327

chr19:47491246

ENST00000404338

1249_1436

1275

1500.0

Domain

Rho-GAP

Tgene

ARHGAP35

chr19:47863327

chr19:47491246

ENST00000404338

270_327

1275

1500.0

Domain

Note=FF 1

Tgene

ARHGAP35

chr19:47863327

chr19:47491246

ENST00000404338

368_422

1275

1500.0

Domain

Note=FF 2

Tgene

ARHGAP35

chr19:47863327

chr19:47491246

ENST00000404338

429_483

1275

1500.0

Domain

Note=FF 3

Tgene

ARHGAP35

chr19:47863327

chr19:47491246

ENST00000404338

485_550

1275

1500.0

Domain

Note=FF 4

Tgene

ARHGAP35

chr19:47863327

chr19:47491246

ENST00000404338

592_767

1275

1500.0

Domain

pG1 pseudoGTPase

Tgene

ARHGAP35

chr19:47863327

chr19:47491246

ENST00000404338

783_947

1275

1500.0

Domain

pG2 pseudoGTPase

Tgene

ARHGAP35

chr19:47863327

chr19:47491246

ENST00000404338

201_203

1275

1500.0

Nucleotide binding

GTP

Tgene

ARHGAP35

chr19:47863327

chr19:47491246

ENST00000404338

229_231

1275

1500.0

Nucleotide binding

GTP

Tgene

ARHGAP35

chr19:47863327

chr19:47491246

ENST00000404338

33_37

1275

1500.0

Nucleotide binding

GTP

Tgene

ARHGAP35

chr19:47863327

chr19:47491246

ENST00000404338

95_97

1275

1500.0

Nucleotide binding

GTP

Tgene

ARHGAP35

chr19:47863327

chr19:47491246

ENST00000404338

1213_1236

1275

1500.0

Region

Required for phospholipid binding and regulation of the substrate preference

Tgene

ARHGAP35

chr19:47863327

chr19:47491246

ENST00000404338

1_266

1275

1500.0

Region

Has GTPase activity%2C required for proper localization

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Fusion Gene Sequence for DHX34-ARHGAP35

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>22665_22665_1_DHX34-ARHGAP35_DHX34_chr19_47863327_ENST00000328771_ARHGAP35_chr19_47491246_ENST00000404338_length(transcript)=6787nt_BP=1724nt
ACGAGATGGCTGTGTGCGCAGGCGCAAGACTAGCGCTCTTGGGACCGGAAGTTAAGGCGTTCGCGGCGTGTGAATCCAGGGCCTGAAAAC
CCAGAATGAACTTGTGTCCATCCCAGAGATCACTGCAGATGTCATGAGGTACCCTTTGTGTCACCAGCTCAAGCAGGCCTCTGGCCACTT
TATCATCTGTGGTGGTCCTGTGCCGTGACCAGGAGGAAAAATTAGCTCTTTGAAGAGAAAGTAGTTCTCTATTGCAGGCACTGGCCTCTT
AAATTGTTGCAGGTGGGGAATGGATGAGAATATTTGTTTTGGGTGATCAGAACTGAGACTCCTATTGTGGATTAGTAACATGCCTCCTCC
TAGAACAAGGGAGGGCAGGGATCGCCGAGACCACCACCGGGCTCCCAGCGAGGAAGAGGCCTTGGAGAAATGGGACTGGAATTGTCCAGA
GACGCGTCGCCTCTTGGAAGATGCCTTCTTCCGTGAAGAGGATTACATCCGTCAGGGTTCTGAGGAATGTCAGAAGTTTTGGACCTTCTT
TGAACGCCTGCAGAGATTCCAGAATCTCAAGACCTCCAGGAAGGAGGAGAAAGACCCTGGACAGCCCAAGCACAGCATCCCAGCGCTGGC
CGACCTACCTCGCACTTACGACCCACGTTACCGCATCAACCTCTCTGTTCTTGGCCCTGCCACGCGGGGCTCTCAGGGACTGGGCAGGCA
CTTGCCCGCGGAGAGAGTGGCTGAGTTCCGCCGAGCCCTGTTGCACTACCTGGACTTTGGCCAGAAGCAGGCATTTGGGCGTCTGGCCAA
GCTGCAGCGTGAGCGGGCAGCCCTCCCCATCGCCCAGTATGGGAACCGCATCCTGCAGACGCTGAAGGAGCACCAGGTGGTGGTAGTGGC
CGGTGACACCGGCTGTGGCAAGTCCACTCAGGTGCCCCAGTACCTGCTGGCTGCTGGCTTCAGTCATGTGGCGTGCACCCAGCCCCGGCG
GATCGCCTGCATCTCACTGGCCAAGCGTGTGGGCTTTGAGAGCCTCAGTCAGTATGGCTCACAGGTCGGCTACCAGATCCGCTTTGAGAG
CACACGTTCGGCGGCCACCAAGATTGTATTCCTGACAGTGGGGCTGCTCCTGCGACAAATCCAGCGGGAACCCAGCCTGCCCCAGTATGA
GGTCCTGATTGTGGATGAAGTCCATGAGCGGCATCTCCACAACGATTTCCTCCTGGGCGTCCTCCAGCGCCTGTTGCCCACGCGGCCTGA
CCTCAAGGTCATCCTCATGTCGGCCACCATCAACATCTCGCTCTTCTCCAGCTATTTCAGCAATGCCCCTGTGGTACAGGTGCCTGGGAG
GCTGTTCCCCATCACGGTTGTGTACCAGCCGCAGGAGGCGGAGCCGACCACGTCCAAGTCAGAGAAGCTGGACCCGCGGCCTTTCCTGAG
GGTGCTGGAGTCCATTGACCACAAGTACCCGCCTGAGGAGCGGGGTGACCTCCTCGTCTTCCTCAGCGGCATGGCGGAGATCAGCGCCGT
GCTGGAGGCTGCCCAGACCTATGCCAGCCACACCCAGCGCTGGGTGGTACTGCCACTGCACAGCGCCCTGTCTGTGGCCGACCAGGACAA
GGTATTTGATGTGGCACCCCCTGGAGTCCGGAAATGCATCCTCTCCACCAACATTGCTGAGACCTCAGTCACCATTGACGGGATCCGCTT
CGTAGTAGATTCCGGACTGAGCACGGAAGGCATCTACCGGGTCAGCGGGAACAAGTCTGAGATGGAGAGTCTGCAGAGACAGTTTGATCA
AGACCACAACCTGGACCTGGCAGAGAAAGACTTTACGGTGAATACCGTGGCTGGTGCCATGAAGAGCTTTTTCTCAGAACTGCCTGACCC
CCTGGTCCCGTATAACATGCAGATCGACTTGGTGGAAGCACACAAAATCAACGACCGGGAGCAGAAGTTGCATGCCCTTAAGGAGGTATT
AAAGAAATTTCCAAAGGAAAACCACGAAGTCTTCAAGTATGTCATCTCTCACCTAAACAAGGTCAGCCACAACAACAAGGTGAATCTCAT
GACCAGCGAGAACCTCTCCATCTGCTTCTGGCCCACCTTGATGAGACCTGATTTCAGCACTATGGACGCCCTCACAGCCACGCGCACCTA
CCAGACAATCATTGAACTCTTTATCCAGCAGTGCCCCTTCTTCTTCTACAATCGGCCCATCACCGAGCCCCCCGGCGCCAGGCCCAGCTC
CCCCTCTGCCGTGGCTTCCACCGTCCCCTTCCTCACTTCCACGCCTGTCACAAGTCAGCCGTCGCCCCCACAGTCGCCTCCACCCACCCC
CCAGTCCCCAATGCAGCCACTGCTTCCCTCCCAGCTTCAAGCCGAACACACGCTGTGAGCCACCAAGACCTGGGGCGACAGGAGAACCGG
TCCTCTCTCTGACGGGGTGGCATTTGGCCTTGAACAAAACCAAGTCCACTGGGGACAGAGGCAGGGGCAAGTGGCTCTCCCCATTACCTT
CTCAAGACCTCAGTGGGAGCACCAGCCAATGGTACCATCGGCTGGGCTGCCAGGTACCCTGGGCCTGGCGCTGCAGACCTGAGCTGGCTT
GGACCCATTTGAGGACTGAACTAGGCAGGCAATGGCTCCAGTGCCCTCCCTCTGTTCCCTGGACCACCACCCCACGTAGCTGCTCACACC
AGCCTCCGGGTGCCTCCCTCTGCTTGTACAGAGCCCATGGTCGGGACAGTGCCCTGGCCTTTGCCGGGGAGGAGGATGCTCTGAGATTCA
GGGTGGGGCTGGCAACCCCTGAAGAGAACACTTCCTGTTGGTCTGTCTCTTCCCACCTTCCATCTGCACACACCCCCAAGGTAAGGGTAC
AGCCCGGCTGGCGGCCTCCTTGGGAACGTGTAGGCCACGGCTCTGCCACCACTAGGTACCTGCTGAGGGCGCTGGCTCTGCAGATCAGAA
CAACGGAGGATAGCTTTGTGCCTGGACCCAGAGAGTGTGGGACTCCCCGCTTCATCCCCACCGTCCCACTCCACAGCCTTCCCGAAACAT
TCCCTGGCAAACAAAGGAACACTAGGAGAAAAAATGGAAAAACCCTTCCAGTAATTAAAAAGGAAGAAACCACAGAAAGAAAACTACAGA
CCTCAAGATTCCACTCTGTGCCCGCCTCTGCCGGGAGGGAGGGAGGCACACAGGTGGAGCTGACCCTCGTCTTTGTGGCAGCAAAACCAG
GATGCCTGGAGCTGTGGCCTGAGGGCCTGCTGGGGTCCCACTCACCCACTTAGGTCTAGTCGCTAGATCCCCCGTTTTCCCAAGAAGAGG
GTTCGAGCCCTTGGTGGGGACAGCTGGGGAGATGGCAGTGCAGGCTGGAACCTGGGCTGCCCCAGAACACAGTCCATTACGATAGAAACA
CTAATTGAGCATGTGCGTGGGGTGGGGGTGTGTGTGCACATGTGAGTGTGAGTGTGTGTGGGCGCTTGGTGGGGGGTTGGGGACAGCTGG
AAGGTGCCAGGTGCACTTGGGGTTGGGGTTGGTGTGTTGGGTGTTGAAGTGGAATCGTTTCATCCCAGCCATGGAGGCCACCAGCAGGAG
TGTTCATGGGGATGTGGGCGAGGTGGGGCACTTTGAAGGAATGGCGGTCTGCTGGTGCCCTCGAAGGGGCATCCTTCCTGGTCTTCGCTG
ACCCAGAGGCGCTGTGCCTGCATATCATCCACCACCACCCTAGCCCAGCCTTCCCACTGCCCCAGGAAAAGCTCTTCTCCTGGCCACCTC
TGCCCCCCAGCACCTCAAACTTGCATGGCTGGGCTGTGGCCTCTGCGGCCAGGAAGCCTGACACTAGGCACCCCCCAGGCGAGAGCTAGT
GGGGTGCAGAGGGCCCCATGCCAGACAGCCCTTGGGGCTCGTTGCACTTTAAGAAATAGGATCTGTGGTGTATTCCAGGGGGCCTGATGG
ACACCTTTCCCGGGCGTCTGCAGCTGCCCTGCCCGTGCCCGCCTGCAGTGGTTGGAGACGGGAGTGGCCCTTCGGCTCCCGAGCTCCCTC
TGGGGACGGCTGGCTCACTGTCTCCAGTTCTCAATGGCCAACGAAGGTGCTTGGAAACACCTAACCTTGCAAGTTTTACCGCCTTTTGAG
GAACACAAATCGGAGAACAAACCCAGGGTTCAGGCGTGTTTTCTGTGAATGTTGGATGATGAATTTTTGTCTCTTCTGGTGGAGCTGTGC
CTGGCCCTGTAGGCCCAGGGTTGGCTGGAAGGTGACATCTGTGTTTCGTTTTAGCTGAGGTTGGCAGAAACGTTCCCAAACTCCCCCAGC
CCTGGACCCCAGCAGATGAGGAAACGGCCCCATTTACTGACCCCGCCCCCTTTTCGAGGTTATGCTCACCTGGTCAGCTCCTCACGTAAT
TGGGGGTGGAGGGAAAGCATGGTGGTGCCCTGGGCCGTCCCTGTGTGAACGCAGGCAAAAGCAGCCCAGTCCCCCTCACTGCTTGAGCTA
ACACTGCCACCTCTTTTGTGTGAGCACAAAAGCCACGTCCCAAGCCACCTGGCCCGATTCCACAGATGTATGTGCGGCCAGTGACTTCCC
CAGGAGTGTGGAGGGGGTGGTGAGGAGGAGCACCTGGGCTCTCTACCCCTCTCCTCACAGAAGTACCTGAAACTAGGTCTGGGGCACTCC
CAATGCAGCGCCTTGTCAGCCAAGGTGGGCAGGCAGGGACTGTGGCAGCTTATGTCCAAAGGGAGCCCCCATGCACAGGAAGCCACAGGG
TTCCTCTTGTTTCCCCCGCTAACTTCAGCCTCTCATCTGCTGCTCCGGGCTGAGGGACTAGAGGACATCTCGGTCGTTTGAGGGGCATGG
CCAGTCGTGGCAGGCCGGCCTTCAGCGTCCGGTCAGGGAAGCGTGCAGCCCAAATGGGCACTTGCATGGGAGCCACAGAGGAGCGTCCCT
GGGGATTGTTGGGACCATGCTGCCCCCACTCCCGCTTTTGTTGGGGCTCTAAGTTCTGGAAGGTGTGTGCACAGAGGGTGCTCATGGGAC
TCGCATGCAGCTCTCAGCACTGGGTGGGAGGGCGTTGGCTTGTCCAGAATGGGGACGTGGGGCAGCCACCCCTGCCCAGCGAGAGCGCAG
ACACCGTGTGAGGGGACAGCAGCCCTTGGTGCAAAGCCAGAGACTGATCCTGGCTCTGACGGCTGAAGAGGGAAGACCCAAGGCTGGGTG
GCGTGGCTCGTGAATCCACTTAGAATTCTTGGCTTGTGTCGCATACTGGGTGTCACGGCACACATTTACTCTGCATTGTCCCCGTCTTTC
CCATCGCCTAGCGTTTGGGGAGGAACAGGGAGAGAGCTTCGGGGCGTCTGTCTCCGTGCTCTCCTGCCTCCACCGCCTTGGTTTTGCTTC
CTGCTGGAGGCAGGGCACCTGCTGCGACCCAGATTCTTCTGCAGGATGTGTCTGTCTTTGTCACGGTGGACAGAGGGTGACATCATAGGA
GCAGCTCGCTGGCCAGAAGGGGATGGGGGCATCCCTGTGCCTCACTCAGCTCCTGCTGCTCTTAGGGAAAGGAGGCCTGGGTCAAGCCAG
CATCCCCTTGGTAAAGACCCCCGCAGGCCACCAGGCATTCTGGACACGCACACACACACACACACACACACACACACACAAAACTTCACA
GCAGGCCAGCTGCAGTGACTTGTCATCAAGAGTCACCTCAGCTGCGCCCCCCTCCCATCCTTTCCTATGAGAAGCCACTGCTTTGGGGGC
GCCGGCTAGAAAAAGTAGGGTGCGGTGGCCAGGAGGGCCCCTGCCGCGCGGGGGGCTGGGTCTGGTTGAGTCGCTGCTTTCCCGAGGGCA
GCGCAGGGATCCGGGGAAGCTGCGGCAGGGAGCGGGCGCCGGCTTCGTGGCTCTGAGGTGTAACGGGGGTGGGCTCCCTCCCTCGGAGGA
CATCGTCTGTGTCCAGGTCAGAAAGTGGCCCAGGAAGGGGGCAGTTTCTGTCGCGGGTCCGGTGGGGGCGCGGCCGCGGTGCGGTCGGTG
CAGCGTGGCCAATGCGCGGCGCGCGCGGGGGACAGAGCAGGAGGCGGTCTGTCACCTCGGCCACTGCTGACCTGGGCTGGCCTCCCCCAG
CCCTCCCGTGGCGGAGCCGGCAGCGATGCTACAGGCCTAAGTTATTGTTTGCATAAAAAGAATCATGTTCCCTGTGTACATTTAAGAAAA
AAACAAAAAAACGGAAATGTCAGAATTGTATGGAAATAAAACTTGTTTGAAAATTTGGAATAGTGCTGCTGCCAGCTTATTTTTCTGGTA
CTTGTATTTTCACATGTTAAATGATCTTTATATATGTTGAATTAACAAATATTTTGAGTTTCTGAGAAAAAACAAAACATATTAATGGTA
TTGAAATGTGTTAGTAGTCTGGCTGTGTGCCCAAAATTCTGTTTCGCAGCAAAAGTGAAGACCTGTATGTAAAGAAAGTATAACAATTAT
TTCTTTGTATTTTAGGGGCTTTAACCGGAACATCGTCTAGCTGGTGTTAGGAATGTTTGCTTAATTTCCAGACTTTTTTTTAAAAACACA
TCGTGGGTTTTTTGAGGCTCCAACCTGATTAGTGCATGGTCAGCCCTCAATGAAGGCTGAGGCATCTCTGACTGAGGTGTTTTTGTTTGG
TTTTGTTTTTTAAAATCATGTATTTGCTACAAAGTATTGTACTTGTCTCAATGGGAATGGTGTAAAAAACAAAAGGCCTTATGTGATCTG

>22665_22665_1_DHX34-ARHGAP35_DHX34_chr19_47863327_ENST00000328771_ARHGAP35_chr19_47491246_ENST00000404338_length(amino acids)=691AA_BP=466
MRLLLWISNMPPPRTREGRDRRDHHRAPSEEEALEKWDWNCPETRRLLEDAFFREEDYIRQGSEECQKFWTFFERLQRFQNLKTSRKEEK
DPGQPKHSIPALADLPRTYDPRYRINLSVLGPATRGSQGLGRHLPAERVAEFRRALLHYLDFGQKQAFGRLAKLQRERAALPIAQYGNRI
LQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLL
RQIQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLPTRPDLKVILMSATINISLFSSYFSNAPVVQVPGRLFPITVVYQPQEAEPTT
SKSEKLDPRPFLRVLESIDHKYPPEERGDLLVFLSGMAEISAVLEAAQTYASHTQRWVVLPLHSALSVADQDKVFDVAPPGVRKCILSTN
IAETSVTIDGIRFVVDSGLSTEGIYRVSGNKSEMESLQRQFDQDHNLDLAEKDFTVNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKIN
DREQKLHALKEVLKKFPKENHEVFKYVISHLNKVSHNNKVNLMTSENLSICFWPTLMRPDFSTMDALTATRTYQTIIELFIQQCPFFFYN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DHX34-ARHGAP35

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for DHX34-ARHGAP35

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for DHX34-ARHGAP35

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source