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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DHX40-UNC5D (FusionGDB2 ID:22694)

Fusion Gene Summary for DHX40-UNC5D

check button Fusion gene summary
Fusion gene informationFusion gene name: DHX40-UNC5D
Fusion gene ID: 22694
HgeneTgene
Gene symbol

DHX40

UNC5D

Gene ID

79665

137970

Gene nameDEAH-box helicase 40unc-5 netrin receptor D
SynonymsARG147|DDX40|PADPRO34692|Unc5h4
Cytomap

17q23.1

8p12

Type of geneprotein-codingprotein-coding
Descriptionprobable ATP-dependent RNA helicase DHX40DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 40 (RNA helicase)DEAH (Asp-Glu-Ala-His) box polypeptide 40DEAH box protein 40netrin receptor UNC5Dnetrin receptor Unc5h4protein unc-5 homolog 4protein unc-5 homolog Dunc-5 homolog 4unc-5 homolog D
Modification date2020031320200313
UniProtAcc

Q8IX18

.
Ensembl transtripts involved in fusion geneENST00000251241, ENST00000451169, 
ENST00000425628, 		ENST00000416672, 
ENST00000420357, ENST00000449677, 
ENST00000287272, ENST00000404895, 
ENST00000453357, 
Fusion gene scores* DoF score9 X 8 X 7=50417 X 13 X 6=1326
# samples 1120
** MAII scorelog2(11/504*10)=-2.19592020997526
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/1326*10)=-2.72900887033786
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DHX40 [Title/Abstract] AND UNC5D [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDHX40(57644155)-UNC5D(35406810), # samples:1
DHX40(57685712)-UNC5D(35563447), # samples:1
Anticipated loss of major functional domain due to fusion event.DHX40-UNC5D seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DHX40-UNC5D seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUNC5D

GO:0098742

cell-cell adhesion via plasma-membrane adhesion molecules

26235030


check buttonFusion gene breakpoints across DHX40 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UNC5D (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-78-7147-01ADHX40chr17

57644155

+UNC5Dchr8

35406810

+
ChimerDB4LUADTCGA-78-7147-01ADHX40chr17

57685712

-UNC5Dchr8

35563447

+


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Fusion Gene ORF analysis for DHX40-UNC5D

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000251241ENST00000416672DHX40chr17

57685712

-UNC5Dchr8

35563447

+
5CDS-intronENST00000251241ENST00000420357DHX40chr17

57685712

-UNC5Dchr8

35563447

+
5CDS-intronENST00000251241ENST00000449677DHX40chr17

57644155

+UNC5Dchr8

35406810

+
5CDS-intronENST00000251241ENST00000449677DHX40chr17

57685712

-UNC5Dchr8

35563447

+
5UTR-3CDSENST00000451169ENST00000287272DHX40chr17

57644155

+UNC5Dchr8

35406810

+
5UTR-3CDSENST00000451169ENST00000404895DHX40chr17

57644155

+UNC5Dchr8

35406810

+
5UTR-3CDSENST00000451169ENST00000416672DHX40chr17

57644155

+UNC5Dchr8

35406810

+
5UTR-3CDSENST00000451169ENST00000420357DHX40chr17

57644155

+UNC5Dchr8

35406810

+
5UTR-3CDSENST00000451169ENST00000453357DHX40chr17

57644155

+UNC5Dchr8

35406810

+
5UTR-intronENST00000451169ENST00000449677DHX40chr17

57644155

+UNC5Dchr8

35406810

+
Frame-shiftENST00000251241ENST00000287272DHX40chr17

57685712

-UNC5Dchr8

35563447

+
Frame-shiftENST00000251241ENST00000404895DHX40chr17

57685712

-UNC5Dchr8

35563447

+
Frame-shiftENST00000251241ENST00000453357DHX40chr17

57685712

-UNC5Dchr8

35563447

+
In-frameENST00000251241ENST00000287272DHX40chr17

57644155

+UNC5Dchr8

35406810

+
In-frameENST00000251241ENST00000404895DHX40chr17

57644155

+UNC5Dchr8

35406810

+
In-frameENST00000251241ENST00000416672DHX40chr17

57644155

+UNC5Dchr8

35406810

+
In-frameENST00000251241ENST00000420357DHX40chr17

57644155

+UNC5Dchr8

35406810

+
In-frameENST00000251241ENST00000453357DHX40chr17

57644155

+UNC5Dchr8

35406810

+
intron-3CDSENST00000425628ENST00000287272DHX40chr17

57644155

+UNC5Dchr8

35406810

+
intron-3CDSENST00000425628ENST00000287272DHX40chr17

57685712

-UNC5Dchr8

35563447

+
intron-3CDSENST00000425628ENST00000404895DHX40chr17

57644155

+UNC5Dchr8

35406810

+
intron-3CDSENST00000425628ENST00000404895DHX40chr17

57685712

-UNC5Dchr8

35563447

+
intron-3CDSENST00000425628ENST00000416672DHX40chr17

57644155

+UNC5Dchr8

35406810

+
intron-3CDSENST00000425628ENST00000420357DHX40chr17

57644155

+UNC5Dchr8

35406810

+
intron-3CDSENST00000425628ENST00000453357DHX40chr17

57644155

+UNC5Dchr8

35406810

+
intron-3CDSENST00000425628ENST00000453357DHX40chr17

57685712

-UNC5Dchr8

35563447

+
intron-3CDSENST00000451169ENST00000287272DHX40chr17

57685712

-UNC5Dchr8

35563447

+
intron-3CDSENST00000451169ENST00000404895DHX40chr17

57685712

-UNC5Dchr8

35563447

+
intron-3CDSENST00000451169ENST00000453357DHX40chr17

57685712

-UNC5Dchr8

35563447

+
intron-intronENST00000425628ENST00000416672DHX40chr17

57685712

-UNC5Dchr8

35563447

+
intron-intronENST00000425628ENST00000420357DHX40chr17

57685712

-UNC5Dchr8

35563447

+
intron-intronENST00000425628ENST00000449677DHX40chr17

57644155

+UNC5Dchr8

35406810

+
intron-intronENST00000425628ENST00000449677DHX40chr17

57685712

-UNC5Dchr8

35563447

+
intron-intronENST00000451169ENST00000416672DHX40chr17

57685712

-UNC5Dchr8

35563447

+
intron-intronENST00000451169ENST00000420357DHX40chr17

57685712

-UNC5Dchr8

35563447

+
intron-intronENST00000451169ENST00000449677DHX40chr17

57685712

-UNC5Dchr8

35563447

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000251241DHX40chr1757644155+ENST00000287272UNC5Dchr835406810+89664271472978943
ENST00000251241DHX40chr1757644155+ENST00000453357UNC5Dchr835406810+728542714731851012
ENST00000251241DHX40chr1757644155+ENST00000404895UNC5Dchr835406810+324842714731851012
ENST00000251241DHX40chr1757644155+ENST00000420357UNC5Dchr835406810+32704271472984945
ENST00000251241DHX40chr1757644155+ENST00000416672UNC5Dchr835406810+384642714732001017

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000251241ENST00000287272DHX40chr1757644155+UNC5Dchr835406810+5.71E-050.9999429
ENST00000251241ENST00000453357DHX40chr1757644155+UNC5Dchr835406810+0.000108620.9998914
ENST00000251241ENST00000404895DHX40chr1757644155+UNC5Dchr835406810+0.0006299690.99937004
ENST00000251241ENST00000420357DHX40chr1757644155+UNC5Dchr835406810+0.00044880.99955124
ENST00000251241ENST00000416672DHX40chr1757644155+UNC5Dchr835406810+0.0003668090.9996332

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Fusion Genomic Features for DHX40-UNC5D


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DHX40chr1757644155+UNC5Dchr835406809+3.97E-081
DHX40chr1757644155+UNC5Dchr835406809+3.97E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DHX40-UNC5D


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:57644155/chr8:35406810)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DHX40

Q8IX18

.
FUNCTION: Probable ATP-dependent RNA helicase. {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDHX40chr17:57644155chr8:35406810ENST00000251241+21876_8393780.0Nucleotide bindingATP
TgeneUNC5Dchr17:57644155chr8:35406810ENST00000404895017153_24434954.0DomainNote=Ig-like C2-type
TgeneUNC5Dchr17:57644155chr8:35406810ENST00000404895017252_30634954.0DomainTSP type-1 1
TgeneUNC5Dchr17:57644155chr8:35406810ENST00000404895017308_36034954.0DomainTSP type-1 2
TgeneUNC5Dchr17:57644155chr8:35406810ENST00000404895017542_68234954.0DomainZU5
TgeneUNC5Dchr17:57644155chr8:35406810ENST0000040489501754_15134954.0DomainNote=Ig-like
TgeneUNC5Dchr17:57644155chr8:35406810ENST00000404895017859_93634954.0DomainNote=Death
TgeneUNC5Dchr17:57644155chr8:35406810ENST00000453357017153_24429949.0DomainNote=Ig-like C2-type
TgeneUNC5Dchr17:57644155chr8:35406810ENST00000453357017252_30629949.0DomainTSP type-1 1
TgeneUNC5Dchr17:57644155chr8:35406810ENST00000453357017308_36029949.0DomainTSP type-1 2
TgeneUNC5Dchr17:57644155chr8:35406810ENST00000453357017542_68229949.0DomainZU5
TgeneUNC5Dchr17:57644155chr8:35406810ENST0000045335701754_15129949.0DomainNote=Ig-like
TgeneUNC5Dchr17:57644155chr8:35406810ENST00000453357017859_93629949.0DomainNote=Death
TgeneUNC5Dchr17:57644155chr8:35406810ENST0000040489501733_37934954.0Topological domainExtracellular
TgeneUNC5Dchr17:57644155chr8:35406810ENST00000404895017401_95334954.0Topological domainCytoplasmic
TgeneUNC5Dchr17:57644155chr8:35406810ENST0000045335701733_37929949.0Topological domainExtracellular
TgeneUNC5Dchr17:57644155chr8:35406810ENST00000453357017401_95329949.0Topological domainCytoplasmic
TgeneUNC5Dchr17:57644155chr8:35406810ENST00000404895017380_40034954.0TransmembraneHelical
TgeneUNC5Dchr17:57644155chr8:35406810ENST00000453357017380_40029949.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDHX40chr17:57644155chr8:35406810ENST00000251241+218263_44293780.0DomainHelicase C-terminal
HgeneDHX40chr17:57644155chr8:35406810ENST00000251241+21863_23193780.0DomainHelicase ATP-binding
HgeneDHX40chr17:57644155chr8:35406810ENST00000425628+117263_4420703.0DomainHelicase C-terminal
HgeneDHX40chr17:57644155chr8:35406810ENST00000425628+11763_2310703.0DomainHelicase ATP-binding
HgeneDHX40chr17:57644155chr8:35406810ENST00000251241+218173_17693780.0MotifNote=DEAH box
HgeneDHX40chr17:57644155chr8:35406810ENST00000425628+117173_1760703.0MotifNote=DEAH box
HgeneDHX40chr17:57644155chr8:35406810ENST00000425628+11776_830703.0Nucleotide bindingATP


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Fusion Gene Sequence for DHX40-UNC5D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22694_22694_1_DHX40-UNC5D_DHX40_chr17_57644155_ENST00000251241_UNC5D_chr8_35406810_ENST00000287272_length(transcript)=8966nt_BP=427nt
CCACGTCATCGAGCAGCTCCCCCTCCCCTTGCTACAAGTCGCACGCGCGGAAGTAAACACCTCTACGTCATCAGGGCGCGTCCTCGTCTT
TCCCCTCCCATCTCCTCAGATCGGTGGACGTGCTCGCCTCCACTCGGGGCCAGGTCTATGTCCCGGTTTCCCGCAGTCGCGGGCAGGGCG
CCAAGGCGGCAGGAGGAGGGTGAGCGGTCAAGAGACCTCCAGGAAGAGCGGCTCTCGGCTGTTTGCATCGCCGATAGAGAAGAGAAAGGA
TGCACGTCCCAGGAGGGAGGAACTACTCCAACTTTTCCTATTCAGAAACAAAGAAAAAAGATTATTCAAGCTGTGAGGGACAATTCATTC
CTTATTGTTACTGGAAATACAGGAAGTGGTAAAACAACTCAACTCCCAAAATATCTATATGAAGCAGGAACTGACAATGGCGAAGCCCTT
CCCGAATCCATCCCATCAGCTCCTGGGACACTGCCTCATTTCATAGAGGAGCCAGATGATGCTTATATTATCAAGAGCAACCCTATTGCA
CTCAGGTGCAAAGCGAGGCCAGCCATGCAGATATTCTTCAAATGCAACGGCGAGTGGGTCCATCAGAACGAGCACGTCTCTGAAGAGACT
CTGGACGAGAGCTCAGGTTTGAAGGTCCGCGAAGTGTTCATCAATGTTACTAGGCAACAGGTGGAGGACTTCCATGGGCCCGAGGACTAT
TGGTGCCAGTGTGTGGCGTGGAGCCACCTGGGTACCTCCAAGAGCAGGAAGGCCTCTGTGCGCATAGCCTATTTACGGAAAAACTTTGAA
CAAGACCCACAAGGAAGGGAAGTTCCCATTGAAGGCATGATTGTACTGCACTGCCGCCCACCAGAGGGAGTCCCTGCTGCCGAGGTGGAA
TGGCTGAAAAATGAAGAGCCCATTGACTCTGAACAAGACGAGAACATTGACACCAGGGCTGACCATAACCTGATCATCAGGCAGGCACGG
CTCTCGGACTCAGGAAATTACACCTGCATGGCAGCCAACATCGTGGCTAAGAGGAGAAGCCTGTCGGCCACTGTTGTGGTCTACGTGGAT
GGGAGCTGGGAAGTGTGGAGCGAATGGTCCGTCTGCAGTCCAGAGTGTGAACATTTGCGGATCCGGGAGTGCACAGCACCACCCCCGAGA
AATGGGGGCAAATTCTGTGAAGGTCTAAGCCAGGAATCTGAAAACTGCACAGATGGTCTTTGCATCCTAGATAAAAAACCTCTTCATGAA
ATAAAACCCCAAAGCATTGAGAATGCCAGCGACATTGCTTTGTACTCGGGCTTGGGTGCTGCCGTCGTGGCCGTTGCAGTCCTGGTCATT
GGTGTCACCCTTTACAGACGGAGCCAGAGTGACTATGGCGTGGACGTCATTGACTCTTCTGCATTGACAGGTAACTCCCTGCTCCTGAAT
TCTGCCATGCAGCCAGATCTGACAGTGAGCCGGACATACAGCGGACCCATCTGTCTGCAGGACCCTCTGGACAAGGAGCTCATGACAGAG
TCCTCACTCTTTAACCCTTTGTCGGACATCAAAGTGAAAGTCCAGAGCTCGTTCATGGTTTCCCTGGGAGTGTCTGAGAGAGCTGAGTAC
CACGGCAAGAATCATTCCAGGACTTTTCCCCATGGAAACAACCACAGCTTTAGTACAATGCATCCCAGAAATAAAATGCCCTACATCCAA
AATCTGTCATCACTCCCCACAAGGACAGAACTGAGGACAACTGGTGTCTTTGGCCATTTAGGGGGGCGCTTAGTAATGCCAAATACAGGG
GTGAGCTTACTCATACCACACGGTGCCATCCCAGAGGAGAATTCTTGGGAGATTTATATGTCCATCAACCAAGGTGAACCCAGCCTCCAG
TCAGATGGCTCTGAGGTGCTCCTGAGTCCTGAAGTCACCTGTGGTCCTCCAGACATGATCGTCACCACTCCCTTTGCATTGACCATCCCG
CACTGTGCAGATGTCAGTTCTGAGCATTGGAATATCCATTTAAAGAAGAGGACACAGCAGGGCAAATGGGAGGAAGTGATGTCAGTGGAA
GATGAATCTACATCCTGTTACTGCCTTTTGGACCCCTTTGCGTGTCATGTGCTCCTGGACAGCTTTGGGACCTATGCGCTCACTGGAGAG
CCAATCACAGACTGTGCCGTGAAGCAACTGAAGGTGGCGGTTTTTGGCTGCATGTCCTGTAACTCCCTGGATTACAACTTGAGAGTTTAC
TGTGTGGACAATACCCCTTGTGCATTTCAGGAAGTGGTTTCAGATGAAAGGCATCAAGGTGGACAGCTCCTGGAAGAACCAAAATTGCTG
CATTTCAAAGGGAATACCTTTAGTCTTCAGATTTCTGTCCTTGATATTCCCCCATTCCTCTGGAGAATTAAACCATTCACTGCCTGCCAG
GAAGTCCCGTTCTCCCGCGTGTGGTGCAGTAACCGGCAGCCCCTGCACTGTGCCTTCTCCCTGGAGCGTTATACGCCCACTACCACCCAG
CTGTCCTGCAAAATCTGCATTCGGCAGCTCAAAGGCCATGAACAGATCCTCCAAGTGCAGACATCAATCCTAGAGAGTGAACGAGAAACC
ATCACTTTCTTCGCACAAGAGGACAGCACTTTCCCTGCACAGACTGGCCCCAAAGCCTTCAAAATTCCCTACTCCATCAGACAGCGGATT
TGTGCTACATTTGATACCCCCAATGCCAAAGGCAAGGACTGGCAGATGTTAGCACAGAAAAACAGCATCAACAGGAATTTATCTTATTTC
GCTACACAAAGTAGCCCATCTGCTGTCATTTTGAACCTGTGGGAAGCTCGTCATCAGCATGATGGTGATCTTGACTCCCTGGCCTGTGCC
CTTGAAGAGATTGGGAGGACACACACGAAACTCTCAAACATTTCAGAATCCCAGCTTGATGAAGCCGACTTCAACTACAGCAGGCAAAAT
GGACTCTAGTCCACTTCCTCCCATGAGACAGAGTGATGGCCAGCTTGGGGACATTTGCTTTAAATGGGAAAGAGGCCGCTTTCTGCCCAG
TGGCGTTGGGGGAATTCAGCCTTCATTTATAATCAGTGAGATTCCCCTGTTGAAGAAACTAAATTTTATATAGGTAAAACATGTTAATAG
GGAAGAGTACAAGCTCTCTTACATATAAGAGGGCTCTACTATCTCCTTGGAATCCACATTTGGGTTAACTCCTCAGATTTGGAGTGGCAA
GGATAAAAGTGAGGGCAGAAGTAGCTGTGGGAAAAGATGAGCTATGATAATGCTGGGAAGGCAGAGATTGATTAAGTGCATGCTTTGAAA
TAGGTTTTTAATGATGTGCCCCAAAGGGCCAGCTGATTCTGGTACTAGATTGTCAGAGTTTTCTACCAACTGGCATCTGTGATGTCAGAG
ATCATTGTAAAAATGGCTTTTAGACGTGAAACAGGGTTGCCAACCCATTTGTATGACTTCAACAACGTCAAGGAGGGCATTTAGAATTTA
GAATCTGAGCACATCACACCAGCACCAGCTCCCTGTCTCTTCTAGCCACTTAATGGAGACACAATGGAGAGGTAAGACAGACCACAAACT
AGTTCTTATAGTGTACTCCACCTTTTACTTTTTTCCTGAGACAAATCTACCCTTATTCTTTCTTCCTCTTCCTTACCCCTTGCAGTAGGG
AGGTATCAAGGAGCATAATTAAACTTGTCAATACGGAAAGTTGTTTTTTCTAACACAACAAAGTGGGACCATCTCTATTCCCATCTAAGC
CACTCAAATTGCTGAGTGCTATTAGAACACAGCTTATTACATGGATATGGGGACAGGAGAGATTAAAGCAGGTTCAAAAACACATGAACT
GCAGATGCCATAGGCCTCAAATCAGCTGTAATTCTAGGAGACACGTGTTGATCTAGTTATCTAACATTGTTGTTATAAGAAAATGAGTTT
ACTGCATTTTTCAATCCAGATTCTTGAAATTGTCTAACATGTGGGTACTGTGTCATCACAAAATCTCTCAGTAAGGCTATATGTGATCCT
CATTTTGCCTCTTGGGAAATTAGCAGATAGTCTTTGCTCTAAATGATATCTGAGTAAATAGACTTGAGGAATCCTCTACCACAGTGTCCC
TGAAACCACATGCATCATTCAGGAAGCCTTCACCCTGTGACTATTCAGCCTCCCTGAATATGCTTTCTCTATAGAACCACTAACATATGG
CTATTGCTCTATGATTTTTTTTTTTACATTAGGAGGCAGTGATATTGTGGAAGATTGAAATCCACAGATAATTCATGACCCTCATCTTAT
CACTTTACTCCATCTTTTTATCCTATTAAATTATTTTTGACAAGATGTCCTGGTAGACTAAAGGTGAACAGATTTGCTCTTGCTCATCTT
CTGGTGGATATTTTAACTTGCTATTCACAATCAGGACAACCAAAGTCAAGGACCCAGATGAACCACAAGGCAGCTAGTCAGCTACTTAGA
GGTTGGTTACATTCGAATAAAAAGTAGTCAGGGAATGGGGGAGGTGGGGAGTTGGGGAGTACTTGGCAGTTGGGATATGATCCATTTTTT
TAAACAAGTTTTTTGTAGATCCCTTGTAAAATAATAATAATAATGTTGTGAATCTCCATGCCAAGTGAAAAAGGCCTAAAGATGAGTTGA
ATTTGTGATACCATGGGTAAGGCATGGAAGAACTCTTGAATGTGTTGGCCATTTTCTCTAACTAACATGTGGTATGTATGGTCCCCTATA
TTAGATAGAAGTCTTTGCTACATGTAATTCAAAAGCATCTCGCTTTTCTCAGGAACCAAAGGCTTATGATGTAGGACAAAGAAATCATCT
TAGAACTGTCAAGCATATTTTCACAATACCATGTCAAGATCAGGAAAACACCCTTTTGCTAGTGTGCTTAACTTATTTATTTCTTCTAGG
AAACAATAGATAAACAGCATGAAAATGTAAATCATCTGGCATCACTGATAGAATTTCTGAAAGAGAAAGAGAAGTAGATGGTCAACCAGT
CACTAGTTGGTTGGCATGAGGTGGTGTGCAGAGGAAAGCTGCATTCACTATTGAGTAAAAACTTGTAGAAAGCACATTATAGAGCTTATG
TTGGAATCCATCTTGGAGGATTTTTGTTTTAAACTGTCTTTAGCATTTTCCCTCTTCCCTTCTAATGGGCATTATAATTGTTTCATCTAC
TCTGTGAATCTACATAGGTCTTTTTTTTTAGATGTTTGATACATTTTAAGTATTTTTAAATAGATGAAAATTCTAAATGATTTTCCCTCA
AATCTATCTAGATTATTTTAAGATGAGACAAGATTATTGTCAATCCCTGAATGTCTGGAGTTACCTCCCATGGATTTTTTTTTCCTTTGG
CCTGGGTTTTATAAACAACTTGAACATCATATCATATAGGATAACAAAGGAGGAAGTTAACTTAATTCACCTCAGACTTCAGCCTAAGAT
TCAATCAAATTCATCCTTCAGCCTGTCTTGTTTCTTCTTTATGTTTCTTTTACTTATTGCTGCTAGGATCCTACATAGGATTTCTATAGA
AATGTATGAAATTCTGTGGTCACTGCATGTCAGGATTGCACAGTATGTTACAATACAATTTCAAAGAGAACCCACATTTGTGAGATTTAC
AGACCAAGGTGTGGTGGAGGAGGTAGAATTGCAGATCAGATAAAAAGTGAGCTTACACTTGAACTTAGTTATTCACTGTGACCTAAATTT
AGTCCTATTGTAATATGTGCCTGTCACAACACAAATACCCCTCTTGAAAGAGATTTACTCATCTATCCAAGCACTTAATTTGGAAATTTT
ATTGTCCTATTGCAAAATGAAACAAAATTAAAAGTGGCCTCGAGTACTTGGTAAGTTACTTAAAATTTTTACAAAAATATCCCACTCAAT
GCCAAATCTTTCAGTCCTCAAAGGCATTTAAGTCCAATAGTCATGCTTTAAATATGGCTTTAAATTATGCCACCAAAATGGTGCACTTCA
CAGATTCACCAGACTGTAGCATCATAAAGTTAATTTACAGTTTTTACAACATTGCTTCTACATTCTTACTGGTTTACATTAAAATCCTTT
AAGCCAAAAGGAAGCTTGCTCTATGGATTTAAATGCAAACTTCATTTACCAGTGCAGGAAGTCTCATAAAACTCAGATGTACTCCCACAA
AAATTTTATTGGCCTTTTTGTAAGAGATGAAAAAGAATTGACACAGTTCTCTTTAAAGAGAAGAACTTTTTTATTATTATTTTTATCTCC
AACTGCAGGTGGTGTCTTTTGCCAAGGTCTCTGTATTTTTCTTTCAGTTGTCTTTGGGAGGGGATGTTAAGTCAAATCACTAAAACAGGG
TTCTCTTTGGATTAAAAGTTCTGGATTTATTGCAACTATTTTCCTTGAGAAACATTCTCAGCATCAGGATTGATAAACAAATGTAGATGA
TTAAAATAGGATAATTGGTTTTAGATAATATCTTCTACTGCCAAACTTCTGGCAAATTTACCTGTGAATTTCAAAATGTTATAAAATCTC
TTGATATGCTTTTGTTTTTCCTTTTAGCCATTTTCTCTTCAATTTCTTAGTCCCTCTGCCCTCTGTAAATGTGTTGAGTGATATAGCTAT
CAGATGTATTGAAGGCAAAGTTCTCGCAGAGGTCTCTGTTCCAGCTCTGTAAAGGTCACAGGAATCGTGAAGGAGCTGAGAAATCTTCCT
CTCCGGCCCACTGTCTGTGGCCCATTGTCATTGTTTCCTCATGAAACATTGCAGAGTTTGAATCCTCAGTAACTCTCATTGACTGGATTA
GAGGTGATGGCCACAGCAAATGGGAGAGCAAAATGTTGGCCTACAGAGAATGACACAATTTTATTCGCCTTTGGTGTTAGTTGCCATAGT
GCTGTATTTGAAAATCGATGCTTTAGCCAAAAGCTGAATGACCACCGTTTCCGTAGTTTCCACTGTTTTGTCTGCATAGAATTTTCCTGA
ACTACAAGCAAAAATGTATTTTGTCCAATGTCACAAAAGTGAAAATGTTACTAATCTTAGATGTGTTGCATATTTTGTGTTTTTACGTTC
CAAACTCTTTCAAAAGCTGCCGTTACAAAGCTGTTTGGCTGTATTGACAGCATGTGGTGTTTTTACAAAAGCAATTCTAGGAGAGCCAGT
GTCTACCATGAACTCCTGACATCCCCACTCCAGGGTCATTCATGACATTGAAATGGCAACTTGTACACTGTAATTCTTCGAAAAGTAACA
GGGGATGGAAATCAGACCTGGCCGTTAGTCACTAGTGTGTAGTACCGTGATCTGAAGTAGGAAATTTAACTGACATAGAATAATTGTGGT
TTTTGAAGCAGCTACTCATTGCTTTTTCCTTTTGCTGTGAAGATCATGGATTGGGAATGTCCTCGTGAGGTGGACCTAAGGCAGTAACAT
TTAAACTTCATGTCCTAGCACCCGCCCTCCATCTGACCCAAAGATAAAAAAGGCATCAAGCTTCATGGTTATGCCTAAGCTTAAAAATTC
CCTTCCCCACTACTAATATTGAGTTCAGCAGGGCCCCATCTTACTTATTTTTCAAAAAAGTTATAGCTTTGAATTATAGACTATATTACT
AAATTTGGTAAGGTAGTTCTTTGCATGAATGGGAATGTGTGTCAAAATACTTTCACAAAAGGCATGATTACAATGGAAATGCCCCTTTGC
CTCCAGTTTTGCTAACCCTAAAAAGTATTTCACTAATTTCAAGCACTGTTTACACTCAAATCCCAAAATTGGCCAAATTATATAATTCTC
TTAAATTTTCATTTCTGTAGGTGGAGATTTAACTATGGTTCTGGTGAATCATAGAAGGGAGAGACAATATTTGAGGGGAGTTTATCAGCA
GAATATCATGCCTTATGACCCCATTACTGAAACACAGACATTACAATCAGAAATAGACCTAATAATTCCAATATCCCTCCATTAACTAGT
TCCAGTGATGCTGAGAGACACAGCACCCTGTGCCAGGTATCAGAAATATAAGCCTCAGCAGAGGGTAACTGAAAACTTTCAATCAGAAAC
ACTCTCCAAGGCTTATGGCTAGATTATGTAGGTCACTACCATTCAAAACTTTTCTATACAAAGGTGGAAAAGCACTCAGAATCTGGGAAT
TTTCTGGTTGGAAGAACAATGTTCTCCTTTTCCAAATTGGAATAAAGACTCAGAATTACCCATTCTTCATAATCATGTCTGATTGGTACA
TACACTCCAGGAAGTCTCAACCTAGAAACATTTCCAACCTAAGCATTTAAAGGAAAACTGGCTCATTCTTCTGACCCAAACTCAAAAAAT
ATGAGTACTTGCGTACCTCCATTTCTGCATGAAGATTTTAAAACAGATTTCATTTTTTTCTGTTTATTTTGGGAAGGTGCGTGGGGGTGT
TCTTTCAAGTGATTCACATCTCAAACCCATACCACTCTCAACTTTTATTTGATGTGTTCAAAGCCAAAAAATAAAATAAAATAAAGCAGG
GCTGAACACTTAATTTGACATGAAGCTGAAGGACTGAGCAAGCCAGAGGAGAGAGGTTGAATGAAGCATAGCCTTGGCTTCATACCACAC
TTTTTGTGCCTTGTATTATCAATGTAAATTCTGAATGTTGTACAGTAAACTTGGATGGACTTCTTAGAAAAGGCTGCACTGGCTTCTTTT
TCAGCACATGTACATATCTATAAATATATATACATATATATTTGGTAATGCCAAACAGCTCTGTTATATTGTATTGAACAAAATGGACGG
TTTGGATGTTTTATGTCGAGTTTGCAAAAAAAAAAAAAAAAAAAAAAACTGGATGGTTGCAGACTTTTCAAGATAAATGTACAGACGTAA

>22694_22694_1_DHX40-UNC5D_DHX40_chr17_57644155_ENST00000251241_UNC5D_chr8_35406810_ENST00000287272_length(amino acids)=943AA_BP=93
MSRFPAVAGRAPRRQEEGERSRDLQEERLSAVCIADREEKGCTSQEGGTTPTFPIQKQRKKIIQAVRDNSFLIVTGNTGSGKTTQLPKYL
YEAGTDNGEALPESIPSAPGTLPHFIEEPDDAYIIKSNPIALRCKARPAMQIFFKCNGEWVHQNEHVSEETLDESSGLKVREVFINVTRQ
QVEDFHGPEDYWCQCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQGREVPIEGMIVLHCRPPEGVPAAEVEWLKNEEPIDSEQDENIDTR
ADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVDGSWEVWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQESENCTDG
LCILDKKPLHEIKPQSIENASDIALYSGLGAAVVAVAVLVIGVTLYRRSQSDYGVDVIDSSALTGNSLLLNSAMQPDLTVSRTYSGPICL
QDPLDKELMTESSLFNPLSDIKVKVQSSFMVSLGVSERAEYHGKNHSRTFPHGNNHSFSTMHPRNKMPYIQNLSSLPTRTELRTTGVFGH
LGGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLSPEVTCGPPDMIVTTPFALTIPHCADVSSEHWNIHLKKRTQ
QGKWEEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQ
GGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQV
QTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQ

--------------------------------------------------------------
>22694_22694_2_DHX40-UNC5D_DHX40_chr17_57644155_ENST00000251241_UNC5D_chr8_35406810_ENST00000404895_length(transcript)=3248nt_BP=427nt
CCACGTCATCGAGCAGCTCCCCCTCCCCTTGCTACAAGTCGCACGCGCGGAAGTAAACACCTCTACGTCATCAGGGCGCGTCCTCGTCTT
TCCCCTCCCATCTCCTCAGATCGGTGGACGTGCTCGCCTCCACTCGGGGCCAGGTCTATGTCCCGGTTTCCCGCAGTCGCGGGCAGGGCG
CCAAGGCGGCAGGAGGAGGGTGAGCGGTCAAGAGACCTCCAGGAAGAGCGGCTCTCGGCTGTTTGCATCGCCGATAGAGAAGAGAAAGGA
TGCACGTCCCAGGAGGGAGGAACTACTCCAACTTTTCCTATTCAGAAACAAAGAAAAAAGATTATTCAAGCTGTGAGGGACAATTCATTC
CTTATTGTTACTGGAAATACAGGAAGTGGTAAAACAACTCAACTCCCAAAATATCTATATGAAGCAGGAACTGACAATGGCGAAGCCCTT
CCCGAATCCATCCCATCAGCTCCTGGGACACTGCCTCATTTCATAGAGGAGCCAGATGATGCTTATATTATCAAGAGCAACCCTATTGCA
CTCAGGTGCAAAGCGAGGCCAGCCATGCAGATATTCTTCAAATGCAACGGCGAGTGGGTCCATCAGAACGAGCACGTCTCTGAAGAGACT
CTGGACGAGAGCTCAGGTTTGAAGGTCCGCGAAGTGTTCATCAATGTTACTAGGCAACAGGTGGAGGACTTCCATGGGCCCGAGGACTAT
TGGTGCCAGTGTGTGGCGTGGAGCCACCTGGGTACCTCCAAGAGCAGGAAGGCCTCTGTGCGCATAGCCTATTTACGGAAAAACTTTGAA
CAAGACCCACAAGGAAGGGAAGTTCCCATTGAAGGCATGATTGTACTGCACTGCCGCCCACCAGAGGGAGTCCCTGCTGCCGAGGTGGAA
TGGCTGAAAAATGAAGAGCCCATTGACTCTGAACAAGACGAGAACATTGACACCAGGGCTGACCATAACCTGATCATCAGGCAGGCACGG
CTCTCGGACTCAGGAAATTACACCTGCATGGCAGCCAACATCGTGGCTAAGAGGAGAAGCCTGTCGGCCACTGTTGTGGTCTACGTGAAT
GGAGGCTGGTCTTCCTGGACAGAGTGGTCAGCCTGCAATGTTCGCTGTGGTAGAGGATGGCAGAAACGTTCCCGGACCTGCACCAACCCA
GCTCCTCTCAATGGTGGGGCCTTTTGTGAGGGAATGTCAGTGCAGAAAATAACCTGCACTTCTCTTTGTCCTGTGGATGGGAGCTGGGAA
GTGTGGAGCGAATGGTCCGTCTGCAGTCCAGAGTGTGAACATTTGCGGATCCGGGAGTGCACAGCACCACCCCCGAGAAATGGGGGCAAA
TTCTGTGAAGGTCTAAGCCAGGAATCTGAAAACTGCACAGATGGTCTTTGCATCCTAGATAAAAAACCTCTTCATGAAATAAAACCCCAA
AGCATTGAGAATGCCAGCGACATTGCTTTGTACTCGGGCTTGGGTGCTGCCGTCGTGGCCGTTGCAGTCCTGGTCATTGGTGTCACCCTT
TACAGACGGAGCCAGAGTGACTATGGCGTGGACGTCATTGACTCTTCTGCATTGACAGGTGGCTTCCAGACCTTCAACTTCAAAACAGTC
CGTCAAGGTAACTCCCTGCTCCTGAATTCTGCCATGCAGCCAGATCTGACAGTGAGCCGGACATACAGCGGACCCATCTGTCTGCAGGAC
CCTCTGGACAAGGAGCTCATGACAGAGTCCTCACTCTTTAACCCTTTGTCGGACATCAAAGTGAAAGTCCAGAGCTCGTTCATGGTTTCC
CTGGGAGTGTCTGAGAGAGCTGAGTACCACGGCAAGAATCATTCCAGGACTTTTCCCCATGGAAACAACCACAGCTTTAGTACAATGCAT
CCCAGAAATAAAATGCCCTACATCCAAAATCTGTCATCACTCCCCACAAGGACAGAACTGAGGACAACTGGTGTCTTTGGCCATTTAGGG
GGGCGCTTAGTAATGCCAAATACAGGGGTGAGCTTACTCATACCACACGGTGCCATCCCAGAGGAGAATTCTTGGGAGATTTATATGTCC
ATCAACCAAGGTGAACCCAGCCTCCAGTCAGATGGCTCTGAGGTGCTCCTGAGTCCTGAAGTCACCTGTGGTCCTCCAGACATGATCGTC
ACCACTCCCTTTGCATTGACCATCCCGCACTGTGCAGATGTCAGTTCTGAGCATTGGAATATCCATTTAAAGAAGAGGACACAGCAGGGC
AAATGGGAGGAAGTGATGTCAGTGGAAGATGAATCTACATCCTGTTACTGCCTTTTGGACCCCTTTGCGTGTCATGTGCTCCTGGACAGC
TTTGGGACCTATGCGCTCACTGGAGAGCCAATCACAGACTGTGCCGTGAAGCAACTGAAGGTGGCGGTTTTTGGCTGCATGTCCTGTAAC
TCCCTGGATTACAACTTGAGAGTTTACTGTGTGGACAATACCCCTTGTGCATTTCAGGAAGTGGTTTCAGATGAAAGGCATCAAGGTGGA
CAGCTCCTGGAAGAACCAAAATTGCTGCATTTCAAAGGGAATACCTTTAGTCTTCAGATTTCTGTCCTTGATATTCCCCCATTCCTCTGG
AGAATTAAACCATTCACTGCCTGCCAGGAAGTCCCGTTCTCCCGCGTGTGGTGCAGTAACCGGCAGCCCCTGCACTGTGCCTTCTCCCTG
GAGCGTTATACGCCCACTACCACCCAGCTGTCCTGCAAAATCTGCATTCGGCAGCTCAAAGGCCATGAACAGATCCTCCAAGTGCAGACA
TCAATCCTAGAGAGTGAACGAGAAACCATCACTTTCTTCGCACAAGAGGACAGCACTTTCCCTGCACAGACTGGCCCCAAAGCCTTCAAA
ATTCCCTACTCCATCAGACAGCGGATTTGTGCTACATTTGATACCCCCAATGCCAAAGGCAAGGACTGGCAGATGTTAGCACAGAAAAAC
AGCATCAACAGGAATTTATCTTATTTCGCTACACAAAGTAGCCCATCTGCTGTCATTTTGAACCTGTGGGAAGCTCGTCATCAGCATGAT
GGTGATCTTGACTCCCTGGCCTGTGCCCTTGAAGAGATTGGGAGGACACACACGAAACTCTCAAACATTTCAGAATCCCAGCTTGATGAA
GCCGACTTCAACTACAGCAGGCAAAATGGACTCTAGTCCACTTCCTCCCATGAGACAGAGTGATGGCCAGCTTGGGGACATTTGCTTTAA

>22694_22694_2_DHX40-UNC5D_DHX40_chr17_57644155_ENST00000251241_UNC5D_chr8_35406810_ENST00000404895_length(amino acids)=1012AA_BP=93
MSRFPAVAGRAPRRQEEGERSRDLQEERLSAVCIADREEKGCTSQEGGTTPTFPIQKQRKKIIQAVRDNSFLIVTGNTGSGKTTQLPKYL
YEAGTDNGEALPESIPSAPGTLPHFIEEPDDAYIIKSNPIALRCKARPAMQIFFKCNGEWVHQNEHVSEETLDESSGLKVREVFINVTRQ
QVEDFHGPEDYWCQCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQGREVPIEGMIVLHCRPPEGVPAAEVEWLKNEEPIDSEQDENIDTR
ADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVNGGWSSWTEWSACNVRCGRGWQKRSRTCTNPAPLNGGAFCEGMSVQKITC
TSLCPVDGSWEVWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQESENCTDGLCILDKKPLHEIKPQSIENASDIALYSGLGAAVV
AVAVLVIGVTLYRRSQSDYGVDVIDSSALTGGFQTFNFKTVRQGNSLLLNSAMQPDLTVSRTYSGPICLQDPLDKELMTESSLFNPLSDI
KVKVQSSFMVSLGVSERAEYHGKNHSRTFPHGNNHSFSTMHPRNKMPYIQNLSSLPTRTELRTTGVFGHLGGRLVMPNTGVSLLIPHGAI
PEENSWEIYMSINQGEPSLQSDGSEVLLSPEVTCGPPDMIVTTPFALTIPHCADVSSEHWNIHLKKRTQQGKWEEVMSVEDESTSCYCLL
DPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQGGQLLEEPKLLHFKGNTFSLQ
ISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQVQTSILESERETITFFAQEDST
FPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQHDGDLDSLACALEEIGRTHTK

--------------------------------------------------------------
>22694_22694_3_DHX40-UNC5D_DHX40_chr17_57644155_ENST00000251241_UNC5D_chr8_35406810_ENST00000416672_length(transcript)=3846nt_BP=427nt
CCACGTCATCGAGCAGCTCCCCCTCCCCTTGCTACAAGTCGCACGCGCGGAAGTAAACACCTCTACGTCATCAGGGCGCGTCCTCGTCTT
TCCCCTCCCATCTCCTCAGATCGGTGGACGTGCTCGCCTCCACTCGGGGCCAGGTCTATGTCCCGGTTTCCCGCAGTCGCGGGCAGGGCG
CCAAGGCGGCAGGAGGAGGGTGAGCGGTCAAGAGACCTCCAGGAAGAGCGGCTCTCGGCTGTTTGCATCGCCGATAGAGAAGAGAAAGGA
TGCACGTCCCAGGAGGGAGGAACTACTCCAACTTTTCCTATTCAGAAACAAAGAAAAAAGATTATTCAAGCTGTGAGGGACAATTCATTC
CTTATTGTTACTGGAAATACAGGAAGTGGTAAAACAACTCAACTCCCAAAATATCTATATGAAGCAGGAACTGACAATGGCGAAGCCCTT
CCCGAATCCATCCCATCAGCTCCTGGGACACTGCCTCATTTCATAGAGGAGCCAGATGATGCTTATATTATCAAGAGCAACCCTATTGCA
CTCAGGTGCAAAGCGAGGCCAGCCATGCAGATATTCTTCAAATGCAACGGCGAGTGGGTCCATCAGAACGAGCACGTCTCTGAAGAGACT
CTGGACGAGAGCTCAGGTTTGAAGGTCCGCGAAGTGTTCATCAATGTTACTAGGCAACAGGTGGAGGACTTCCATGGGCCCGAGGACTAT
TGGTGCCAGTGTGTGGCGTGGAGCCACCTGGGTACCTCCAAGAGCAGGAAGGCCTCTGTGCGCATAGCCTATTTACGGAAAAACTTTGAA
CAAGACCCACAAGGAAGGGAAGTTCCCATTGAAGGCATGATTGTACTGCACTGCCGCCCACCAGAGGGAGTCCCTGCTGCCGAGGTGGAA
TGGCTGAAAAATGAAGAGCCCATTGACTCTGAACAAGACGAGAACATTGACACCAGGGCTGACCATAACCTGATCATCAGGCAGGCACGG
CTCTCGGACTCAGGAAATTACACCTGCATGGCAGCCAACATCGTGGCTAAGAGGAGAAGCCTGTCGGCCACTGTTGTGGTCTACGTGAAT
GGAGGCTGGTCTTCCTGGACAGAGTGGTCAGCCTGCAATGTTCGCTGTGGTAGAGGATGGCAGAAACGTTCCCGGACCTGCACCAACCCA
GCTCCTCTCAATGGTGGGGCCTTTTGTGAGGGAATGTCAGTGCAGAAAATAACCTGCACTTCTCTTTGTCCTGTGGATGGGAGCTGGGAA
GTGTGGAGCGAATGGTCCGTCTGCAGTCCAGAGTGTGAACATTTGCGGATCCGGGAGTGCACAGCACCACCCCCGAGAAATGGGGGCAAA
TTCTGTGAAGGTCTAAGCCAGGAATCTGAAAACTGCACAGATGGTCTTTGCATCCTAGATAAAAAACCTCTTCATGAAATAAAACCCCAA
AGATGGAGTAGGAGAGGCATTGAGAATGCCAGCGACATTGCTTTGTACTCGGGCTTGGGTGCTGCCGTCGTGGCCGTTGCAGTCCTGGTC
ATTGGTGTCACCCTTTACAGACGGAGCCAGAGTGACTATGGCGTGGACGTCATTGACTCTTCTGCATTGACAGGTGGCTTCCAGACCTTC
AACTTCAAAACAGTCCGTCAAGGTAACTCCCTGCTCCTGAATTCTGCCATGCAGCCAGATCTGACAGTGAGCCGGACATACAGCGGACCC
ATCTGTCTGCAGGACCCTCTGGACAAGGAGCTCATGACAGAGTCCTCACTCTTTAACCCTTTGTCGGACATCAAAGTGAAAGTCCAGAGC
TCGTTCATGGTTTCCCTGGGAGTGTCTGAGAGAGCTGAGTACCACGGCAAGAATCATTCCAGGACTTTTCCCCATGGAAACAACCACAGC
TTTAGTACAATGCATCCCAGAAATAAAATGCCCTACATCCAAAATCTGTCATCACTCCCCACAAGGACAGAACTGAGGACAACTGGTGTC
TTTGGCCATTTAGGGGGGCGCTTAGTAATGCCAAATACAGGGGTGAGCTTACTCATACCACACGGTGCCATCCCAGAGGAGAATTCTTGG
GAGATTTATATGTCCATCAACCAAGGTGAACCCAGCCTCCAGTCAGATGGCTCTGAGGTGCTCCTGAGTCCTGAAGTCACCTGTGGTCCT
CCAGACATGATCGTCACCACTCCCTTTGCATTGACCATCCCGCACTGTGCAGATGTCAGTTCTGAGCATTGGAATATCCATTTAAAGAAG
AGGACACAGCAGGGCAAATGGGAGGAAGTGATGTCAGTGGAAGATGAATCTACATCCTGTTACTGCCTTTTGGACCCCTTTGCGTGTCAT
GTGCTCCTGGACAGCTTTGGGACCTATGCGCTCACTGGAGAGCCAATCACAGACTGTGCCGTGAAGCAACTGAAGGTGGCGGTTTTTGGC
TGCATGTCCTGTAACTCCCTGGATTACAACTTGAGAGTTTACTGTGTGGACAATACCCCTTGTGCATTTCAGGAAGTGGTTTCAGATGAA
AGGCATCAAGGTGGACAGCTCCTGGAAGAACCAAAATTGCTGCATTTCAAAGGGAATACCTTTAGTCTTCAGATTTCTGTCCTTGATATT
CCCCCATTCCTCTGGAGAATTAAACCATTCACTGCCTGCCAGGAAGTCCCGTTCTCCCGCGTGTGGTGCAGTAACCGGCAGCCCCTGCAC
TGTGCCTTCTCCCTGGAGCGTTATACGCCCACTACCACCCAGCTGTCCTGCAAAATCTGCATTCGGCAGCTCAAAGGCCATGAACAGATC
CTCCAAGTGCAGACATCAATCCTAGAGAGTGAACGAGAAACCATCACTTTCTTCGCACAAGAGGACAGCACTTTCCCTGCACAGACTGGC
CCCAAAGCCTTCAAAATTCCCTACTCCATCAGACAGCGGATTTGTGCTACATTTGATACCCCCAATGCCAAAGGCAAGGACTGGCAGATG
TTAGCACAGAAAAACAGCATCAACAGGAATTTATCTTATTTCGCTACACAAAGTAGCCCATCTGCTGTCATTTTGAACCTGTGGGAAGCT
CGTCATCAGCATGATGGTGATCTTGACTCCCTGGCCTGTGCCCTTGAAGAGATTGGGAGGACACACACGAAACTCTCAAACATTTCAGAA
TCCCAGCTTGATGAAGCCGACTTCAACTACAGCAGGCAAAATGGACTCTAGTCCACTTCCTCCCATGAGACAGAGTGATGGCCAGCTTGG
GGACATTTGCTTTAAATGGGAAAGAGGCCGCTTTCTGCCCAGTGGCGTTGGGGGAATTCAGCCTTCATTTATAATCAGTGAGATTCCCCT
GTTGAAGAAACTAAATTTTATATAGGTAAAACATGTTAATAGGGAAGAGTACAAGCTCTCTTACATATAAGAGGGCTCTACTATCTCCTT
GGAATCCACATTTGGGTTAACTCCTCAGATTTGGAGTGGCAAGGATAAAAGTGAGGGCAGAAGTAGCTGTGGGAAAAGATGAGCTATGAT
AATGCTGGGAAGGCAGAGATTGATTAAGTGCATGCTTTGAAATAGGTTTTTAATGATGTGCCCCAAAGGGCCAGCTGATTCTGGTACTAG
ATTGTCAGAGTTTTCTACCAACTGGCATCTGTGATGTCAGAGATCATTGTAAAAATGGCTTTTAGACGTGAAACAGGGTTGCCAACCCAT
TTGTATGACTTCAACAACGTCAAGGAGGGCATTTAGAATTTAGAATCTGAGCACATCACACCAGCACCAGCTCCCTGTCTCTTCTAGCCA

>22694_22694_3_DHX40-UNC5D_DHX40_chr17_57644155_ENST00000251241_UNC5D_chr8_35406810_ENST00000416672_length(amino acids)=1017AA_BP=93
MSRFPAVAGRAPRRQEEGERSRDLQEERLSAVCIADREEKGCTSQEGGTTPTFPIQKQRKKIIQAVRDNSFLIVTGNTGSGKTTQLPKYL
YEAGTDNGEALPESIPSAPGTLPHFIEEPDDAYIIKSNPIALRCKARPAMQIFFKCNGEWVHQNEHVSEETLDESSGLKVREVFINVTRQ
QVEDFHGPEDYWCQCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQGREVPIEGMIVLHCRPPEGVPAAEVEWLKNEEPIDSEQDENIDTR
ADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVNGGWSSWTEWSACNVRCGRGWQKRSRTCTNPAPLNGGAFCEGMSVQKITC
TSLCPVDGSWEVWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQESENCTDGLCILDKKPLHEIKPQRWSRRGIENASDIALYSGL
GAAVVAVAVLVIGVTLYRRSQSDYGVDVIDSSALTGGFQTFNFKTVRQGNSLLLNSAMQPDLTVSRTYSGPICLQDPLDKELMTESSLFN
PLSDIKVKVQSSFMVSLGVSERAEYHGKNHSRTFPHGNNHSFSTMHPRNKMPYIQNLSSLPTRTELRTTGVFGHLGGRLVMPNTGVSLLI
PHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLSPEVTCGPPDMIVTTPFALTIPHCADVSSEHWNIHLKKRTQQGKWEEVMSVEDESTS
CYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQGGQLLEEPKLLHFKGN
TFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQVQTSILESERETITFFA
QEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQHDGDLDSLACALEEIG

--------------------------------------------------------------
>22694_22694_4_DHX40-UNC5D_DHX40_chr17_57644155_ENST00000251241_UNC5D_chr8_35406810_ENST00000420357_length(transcript)=3270nt_BP=427nt
CCACGTCATCGAGCAGCTCCCCCTCCCCTTGCTACAAGTCGCACGCGCGGAAGTAAACACCTCTACGTCATCAGGGCGCGTCCTCGTCTT
TCCCCTCCCATCTCCTCAGATCGGTGGACGTGCTCGCCTCCACTCGGGGCCAGGTCTATGTCCCGGTTTCCCGCAGTCGCGGGCAGGGCG
CCAAGGCGGCAGGAGGAGGGTGAGCGGTCAAGAGACCTCCAGGAAGAGCGGCTCTCGGCTGTTTGCATCGCCGATAGAGAAGAGAAAGGA
TGCACGTCCCAGGAGGGAGGAACTACTCCAACTTTTCCTATTCAGAAACAAAGAAAAAAGATTATTCAAGCTGTGAGGGACAATTCATTC
CTTATTGTTACTGGAAATACAGGAAGTGGTAAAACAACTCAACTCCCAAAATATCTATATGAAGCAGGAACTGACAATGGCGAAGCCCTT
CCCGAATCCATCCCATCAGCTCCTGGGACACTGCCTCATTTCATAGAGGAGCCAGATGATGCTTATATTATCAAGAGCAACCCTATTGCA
CTCAGGTGCAAAGCGAGGCCAGCCATGCAGATATTCTTCAAATGCAACGGCGAGTGGGTCCATCAGAACGAGCACGTCTCTGAAGAGACT
CTGGACGAGAGCTCAGGTTTGAAGGTCCGCGAAGTGTTCATCAATGTTACTAGGCAACAGGTGGAGGACTTCCATGGGCCCGAGGACTAT
TGGTGCCAGTGTGTGGCGTGGAGCCACCTGGGTACCTCCAAGAGCAGGAAGGCCTCTGTGCGCATAGCCTATTTACGGAAAAACTTTGAA
CAAGACCCACAAGGAAGGGAAGTTCCCATTGAAGGCATGATTGTACTGCACTGCCGCCCACCAGAGGGAGTCCCTGCTGCCGAGGTGGAA
TGGCTGAAAAATGAAGAGCCCATTGACTCTGAACAAGACGAGAACATTGACACCAGGGCTGACCATAACCTGATCATCAGGCAGGCACGG
CTCTCGGACTCAGGAAATTACACCTGCATGGCAGCCAACATCGTGGCTAAGAGGAGAAGCCTGTCGGCCACTGTTGTGGTCTACGTGGAT
GGGAGCTGGGAAGTGTGGAGCGAATGGTCCGTCTGCAGTCCAGAGTGTGAACATTTGCGGATCCGGGAGTGCACAGCACCACCCCCGAGA
AATGGGGGCAAATTCTGTGAAGGTCTAAGCCAGGAATCTGAAAACTGCACAGATGGTCTTTGCATCCTAGGCATTGAGAATGCCAGCGAC
ATTGCTTTGTACTCGGGCTTGGGTGCTGCCGTCGTGGCCGTTGCAGTCCTGGTCATTGGTGTCACCCTTTACAGACGGAGCCAGAGTGAC
TATGGCGTGGACGTCATTGACTCTTCTGCATTGACAGGTGGCTTCCAGACCTTCAACTTCAAAACAGTCCGTCAAGGTAACTCCCTGCTC
CTGAATTCTGCCATGCAGCCAGATCTGACAGTGAGCCGGACATACAGCGGACCCATCTGTCTGCAGGACCCTCTGGACAAGGAGCTCATG
ACAGAGTCCTCACTCTTTAACCCTTTGTCGGACATCAAAGTGAAAGTCCAGAGCTCGTTCATGGTTTCCCTGGGAGTGTCTGAGAGAGCT
GAGTACCACGGCAAGAATCATTCCAGGACTTTTCCCCATGGAAACAACCACAGCTTTAGTACAATGCATCCCAGAAATAAAATGCCCTAC
ATCCAAAATCTGTCATCACTCCCCACAAGGACAGAACTGAGGACAACTGGTGTCTTTGGCCATTTAGGGGGGCGCTTAGTAATGCCAAAT
ACAGGGGTGAGCTTACTCATACCACACGGTGCCATCCCAGAGGAGAATTCTTGGGAGATTTATATGTCCATCAACCAAGGTGAACCCAGC
CTCCAGTCAGATGGCTCTGAGGTGCTCCTGAGTCCTGAAGTCACCTGTGGTCCTCCAGACATGATCGTCACCACTCCCTTTGCATTGACC
ATCCCGCACTGTGCAGATGTCAGTTCTGAGCATTGGAATATCCATTTAAAGAAGAGGACACAGCAGGGCAAATGGGAGGAAGTGATGTCA
GTGGAAGATGAATCTACATCCTGTTACTGCCTTTTGGACCCCTTTGCGTGTCATGTGCTCCTGGACAGCTTTGGGACCTATGCGCTCACT
GGAGAGCCAATCACAGACTGTGCCGTGAAGCAACTGAAGGTGGCGGTTTTTGGCTGCATGTCCTGTAACTCCCTGGATTACAACTTGAGA
GTTTACTGTGTGGACAATACCCCTTGTGCATTTCAGGAAGTGGTTTCAGATGAAAGGCATCAAGGTGGACAGCTCCTGGAAGAACCAAAA
TTGCTGCATTTCAAAGGGAATACCTTTAGTCTTCAGATTTCTGTCCTTGATATTCCCCCATTCCTCTGGAGAATTAAACCATTCACTGCC
TGCCAGGAAGTCCCGTTCTCCCGCGTGTGGTGCAGTAACCGGCAGCCCCTGCACTGTGCCTTCTCCCTGGAGCGTTATACGCCCACTACC
ACCCAGCTGTCCTGCAAAATCTGCATTCGGCAGCTCAAAGGCCATGAACAGATCCTCCAAGTGCAGACATCAATCCTAGAGAGTGAACGA
GAAACCATCACTTTCTTCGCACAAGAGGACAGCACTTTCCCTGCACAGACTGGCCCCAAAGCCTTCAAAATTCCCTACTCCATCAGACAG
CGGATTTGTGCTACATTTGATACCCCCAATGCCAAAGGCAAGGACTGGCAGATGTTAGCACAGAAAAACAGCATCAACAGGAATTTATCT
TATTTCGCTACACAAAGTAGCCCATCTGCTGTCATTTTGAACCTGTGGGAAGCTCGTCATCAGCATGATGGTGATCTTGACTCCCTGGCC
TGTGCCCTTGAAGAGATTGGGAGGACACACACGAAACTCTCAAACATTTCAGAATCCCAGCTTGATGAAGCCGACTTCAACTACAGCAGG
CAAAATGGACTCTAGTCCACTTCCTCCCATGAGACAGAGTGATGGCCAGCTTGGGGACATTTGCTTTAAATGGGAAAGAGGCCGCTTTCT
GCCCAGTGGCGTTGGGGGAATTCAGCCTTCATTTATAATCAGTGAGATTCCCCTGTTGAAGAAACTAAATTTTATATAGGTAAAACATGT
TAATAGGGAAGAGTACAAGCTCTCTTACATATAAGAGGGCTCTACTATCTCCTTGGAATCCACATTTGGGTTAACTCCTCAGATTTGGAG

>22694_22694_4_DHX40-UNC5D_DHX40_chr17_57644155_ENST00000251241_UNC5D_chr8_35406810_ENST00000420357_length(amino acids)=945AA_BP=93
MSRFPAVAGRAPRRQEEGERSRDLQEERLSAVCIADREEKGCTSQEGGTTPTFPIQKQRKKIIQAVRDNSFLIVTGNTGSGKTTQLPKYL
YEAGTDNGEALPESIPSAPGTLPHFIEEPDDAYIIKSNPIALRCKARPAMQIFFKCNGEWVHQNEHVSEETLDESSGLKVREVFINVTRQ
QVEDFHGPEDYWCQCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQGREVPIEGMIVLHCRPPEGVPAAEVEWLKNEEPIDSEQDENIDTR
ADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVDGSWEVWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQESENCTDG
LCILGIENASDIALYSGLGAAVVAVAVLVIGVTLYRRSQSDYGVDVIDSSALTGGFQTFNFKTVRQGNSLLLNSAMQPDLTVSRTYSGPI
CLQDPLDKELMTESSLFNPLSDIKVKVQSSFMVSLGVSERAEYHGKNHSRTFPHGNNHSFSTMHPRNKMPYIQNLSSLPTRTELRTTGVF
GHLGGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLSPEVTCGPPDMIVTTPFALTIPHCADVSSEHWNIHLKKR
TQQGKWEEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDER
HQGGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQIL
QVQTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEAR

--------------------------------------------------------------
>22694_22694_5_DHX40-UNC5D_DHX40_chr17_57644155_ENST00000251241_UNC5D_chr8_35406810_ENST00000453357_length(transcript)=7285nt_BP=427nt
CCACGTCATCGAGCAGCTCCCCCTCCCCTTGCTACAAGTCGCACGCGCGGAAGTAAACACCTCTACGTCATCAGGGCGCGTCCTCGTCTT
TCCCCTCCCATCTCCTCAGATCGGTGGACGTGCTCGCCTCCACTCGGGGCCAGGTCTATGTCCCGGTTTCCCGCAGTCGCGGGCAGGGCG
CCAAGGCGGCAGGAGGAGGGTGAGCGGTCAAGAGACCTCCAGGAAGAGCGGCTCTCGGCTGTTTGCATCGCCGATAGAGAAGAGAAAGGA
TGCACGTCCCAGGAGGGAGGAACTACTCCAACTTTTCCTATTCAGAAACAAAGAAAAAAGATTATTCAAGCTGTGAGGGACAATTCATTC
CTTATTGTTACTGGAAATACAGGAAGTGGTAAAACAACTCAACTCCCAAAATATCTATATGAAGCAGGAACTGACAATGGCGAAGCCCTT
CCCGAATCCATCCCATCAGCTCCTGGGACACTGCCTCATTTCATAGAGGAGCCAGATGATGCTTATATTATCAAGAGCAACCCTATTGCA
CTCAGGTGCAAAGCGAGGCCAGCCATGCAGATATTCTTCAAATGCAACGGCGAGTGGGTCCATCAGAACGAGCACGTCTCTGAAGAGACT
CTGGACGAGAGCTCAGGTTTGAAGGTCCGCGAAGTGTTCATCAATGTTACTAGGCAACAGGTGGAGGACTTCCATGGGCCCGAGGACTAT
TGGTGCCAGTGTGTGGCGTGGAGCCACCTGGGTACCTCCAAGAGCAGGAAGGCCTCTGTGCGCATAGCCTATTTACGGAAAAACTTTGAA
CAAGACCCACAAGGAAGGGAAGTTCCCATTGAAGGCATGATTGTACTGCACTGCCGCCCACCAGAGGGAGTCCCTGCTGCCGAGGTGGAA
TGGCTGAAAAATGAAGAGCCCATTGACTCTGAACAAGACGAGAACATTGACACCAGGGCTGACCATAACCTGATCATCAGGCAGGCACGG
CTCTCGGACTCAGGAAATTACACCTGCATGGCAGCCAACATCGTGGCTAAGAGGAGAAGCCTGTCGGCCACTGTTGTGGTCTACGTGAAT
GGAGGCTGGTCTTCCTGGACAGAGTGGTCAGCCTGCAATGTTCGCTGTGGTAGAGGATGGCAGAAACGTTCCCGGACCTGCACCAACCCA
GCTCCTCTCAATGGTGGGGCCTTTTGTGAGGGAATGTCAGTGCAGAAAATAACCTGCACTTCTCTTTGTCCTGTGGATGGGAGCTGGGAA
GTGTGGAGCGAATGGTCCGTCTGCAGTCCAGAGTGTGAACATTTGCGGATCCGGGAGTGCACAGCACCACCCCCGAGAAATGGGGGCAAA
TTCTGTGAAGGTCTAAGCCAGGAATCTGAAAACTGCACAGATGGTCTTTGCATCCTAGATAAAAAACCTCTTCATGAAATAAAACCCCAA
AGCATTGAGAATGCCAGCGACATTGCTTTGTACTCGGGCTTGGGTGCTGCCGTCGTGGCCGTTGCAGTCCTGGTCATTGGTGTCACCCTT
TACAGACGGAGCCAGAGTGACTATGGCGTGGACGTCATTGACTCTTCTGCATTGACAGGTGGCTTCCAGACCTTCAACTTCAAAACAGTC
CGTCAAGGTAACTCCCTGCTCCTGAATTCTGCCATGCAGCCAGATCTGACAGTGAGCCGGACATACAGCGGACCCATCTGTCTGCAGGAC
CCTCTGGACAAGGAGCTCATGACAGAGTCCTCACTCTTTAACCCTTTGTCGGACATCAAAGTGAAAGTCCAGAGCTCGTTCATGGTTTCC
CTGGGAGTGTCTGAGAGAGCTGAGTACCACGGCAAGAATCATTCCAGGACTTTTCCCCATGGAAACAACCACAGCTTTAGTACAATGCAT
CCCAGAAATAAAATGCCCTACATCCAAAATCTGTCATCACTCCCCACAAGGACAGAACTGAGGACAACTGGTGTCTTTGGCCATTTAGGG
GGGCGCTTAGTAATGCCAAATACAGGGGTGAGCTTACTCATACCACACGGTGCCATCCCAGAGGAGAATTCTTGGGAGATTTATATGTCC
ATCAACCAAGGTGAACCCAGCCTCCAGTCAGATGGCTCTGAGGTGCTCCTGAGTCCTGAAGTCACCTGTGGTCCTCCAGACATGATCGTC
ACCACTCCCTTTGCATTGACCATCCCGCACTGTGCAGATGTCAGTTCTGAGCATTGGAATATCCATTTAAAGAAGAGGACACAGCAGGGC
AAATGGGAGGAAGTGATGTCAGTGGAAGATGAATCTACATCCTGTTACTGCCTTTTGGACCCCTTTGCGTGTCATGTGCTCCTGGACAGC
TTTGGGACCTATGCGCTCACTGGAGAGCCAATCACAGACTGTGCCGTGAAGCAACTGAAGGTGGCGGTTTTTGGCTGCATGTCCTGTAAC
TCCCTGGATTACAACTTGAGAGTTTACTGTGTGGACAATACCCCTTGTGCATTTCAGGAAGTGGTTTCAGATGAAAGGCATCAAGGTGGA
CAGCTCCTGGAAGAACCAAAATTGCTGCATTTCAAAGGGAATACCTTTAGTCTTCAGATTTCTGTCCTTGATATTCCCCCATTCCTCTGG
AGAATTAAACCATTCACTGCCTGCCAGGAAGTCCCGTTCTCCCGCGTGTGGTGCAGTAACCGGCAGCCCCTGCACTGTGCCTTCTCCCTG
GAGCGTTATACGCCCACTACCACCCAGCTGTCCTGCAAAATCTGCATTCGGCAGCTCAAAGGCCATGAACAGATCCTCCAAGTGCAGACA
TCAATCCTAGAGAGTGAACGAGAAACCATCACTTTCTTCGCACAAGAGGACAGCACTTTCCCTGCACAGACTGGCCCCAAAGCCTTCAAA
ATTCCCTACTCCATCAGACAGCGGATTTGTGCTACATTTGATACCCCCAATGCCAAAGGCAAGGACTGGCAGATGTTAGCACAGAAAAAC
AGCATCAACAGGAATTTATCTTATTTCGCTACACAAAGTAGCCCATCTGCTGTCATTTTGAACCTGTGGGAAGCTCGTCATCAGCATGAT
GGTGATCTTGACTCCCTGGCCTGTGCCCTTGAAGAGATTGGGAGGACACACACGAAACTCTCAAACATTTCAGAATCCCAGCTTGATGAA
GCCGACTTCAACTACAGCAGGCAAAATGGACTCTAGTCCACTTCCTCCCATGAGACAGAGTGATGGCCAGCTTGGGGACATTTGCTTTAA
ATGGGAAAGAGGCCGCTTTCTGCCCAGTGGCGTTGGGGGAATTCAGCCTTCATTTATAATCAGTGAGATTCCCCTGTTGAAGAAACTAAA
TTTTATATAGGTAAAACATGTTAATAGGGAAGAGTACAAGCTCTCTTACATATAAGAGGGCTCTACTATCTCCTTGGAATCCACATTTGG
GTTAACTCCTCAGATTTGGAGTGGCAAGGATAAAAGTGAGGGCAGAAGTAGCTGTGGGAAAAGATGAGCTATGATAATGCTGGGAAGGCA
GAGATTGATTAAGTGCATGCTTTGAAATAGGTTTTTAATGATGTGCCCCAAAGGGCCAGCTGATTCTGGTACTAGATTGTCAGAGTTTTC
TACCAACTGGCATCTGTGATGTCAGAGATCATTGTAAAAATGGCTTTTAGACGTGAAACAGGGTTGCCAACCCATTTGTATGACTTCAAC
AACGTCAAGGAGGGCATTTAGAATTTAGAATCTGAGCACATCACACCAGCACCAGCTCCCTGTCTCTTCTAGCCACTTAATGGAGACACA
ATGGAGAGGTAAGACAGACCACAAACTAGTTCTTATAGTGTACTCCACCTTTTACTTTTTTCCTGAGACAAATCTACCCTTATTCTTTCT
TCCTCTTCCTTACCCCTTGCAGTAGGGAGGTATCAAGGAGCATAATTAAACTTGTCAATACGGAAAGTTGTTTTTTCTAACACAACAAAG
TGGGACCATCTCTATTCCCATCTAAGCCACTCAAATTGCTGAGTGCTATTAGAACACAGCTTATTACATGGATATGGGGACAGGAGAGAT
TAAAGCAGGTTCAAAAACACATGAACTGCAGATGCCATAGGCCTCAAATCAGCTGTAATTCTAGGAGACACGTGTTGATCTAGTTATCTA
ACATTGTTGTTATAAGAAAATGAGTTTACTGCATTTTTCAATCCAGATTCTTGAAATTGTCTAACATGTGGGTACTGTGTCATCACAAAA
TCTCTCAGTAAGGCTATATGTGATCCTCATTTTGCCTCTTGGGAAATTAGCAGATAGTCTTTGCTCTAAATGATATCTGAGTAAATAGAC
TTGAGGAATCCTCTACCACAGTGTCCCTGAAACCACATGCATCATTCAGGAAGCCTTCACCCTGTGACTATTCAGCCTCCCTGAATATGC
TTTCTCTATAGAACCACTAACATATGGCTATTGCTCTATGATTTTTTTTTTTACATTAGGAGGCAGTGATATTGTGGAAGATTGAAATCC
ACAGATAATTCATGACCCTCATCTTATCACTTTACTCCATCTTTTTATCCTATTAAATTATTTTTGACAAGATGTCCTGGTAGACTAAAG
GTGAACAGATTTGCTCTTGCTCATCTTCTGGTGGATATTTTAACTTGCTATTCACAATCAGGACAACCAAAGTCAAGGACCCAGATGAAC
CACAAGGCAGCTAGTCAGCTACTTAGAGGTTGGTTACATTCGAATAAAAAGTAGTCAGGGAATGGGGGAGGTGGGGAGTTGGGGAGTACT
TGGCAGTTGGGATATGATCCATTTTTTTAAACAAGTTTTTTGTAGATCCCTTGTAAAATAATAATAATAATGTTGTGAATCTCCATGCCA
AGTGAAAAAGGCCTAAAGATGAGTTGAATTTGTGATACCATGGGTAAGGCATGGAAGAACTCTTGAATGTGTTGGCCATTTTCTCTAACT
AACATGTGGTATGTATGGTCCCCTATATTAGATAGAAGTCTTTGCTACATGTAATTCAAAAGCATCTCGCTTTTCTCAGGAACCAAAGGC
TTATGATGTAGGACAAAGAAATCATCTTAGAACTGTCAAGCATATTTTCACAATACCATGTCAAGATCAGGAAAACACCCTTTTGCTAGT
GTGCTTAACTTATTTATTTCTTCTAGGAAACAATAGATAAACAGCATGAAAATGTAAATCATCTGGCATCACTGATAGAATTTCTGAAAG
AGAAAGAGAAGTAGATGGTCAACCAGTCACTAGTTGGTTGGCATGAGGTGGTGTGCAGAGGAAAGCTGCATTCACTATTGAGTAAAAACT
TGTAGAAAGCACATTATAGAGCTTATGTTGGAATCCATCTTGGAGGATTTTTGTTTTAAACTGTCTTTAGCATTTTCCCTCTTCCCTTCT
AATGGGCATTATAATTGTTTCATCTACTCTGTGAATCTACATAGGTCTTTTTTTTTAGATGTTTGATACATTTTAAGTATTTTTAAATAG
ATGAAAATTCTAAATGATTTTCCCTCAAATCTATCTAGATTATTTTAAGATGAGACAAGATTATTGTCAATCCCTGAATGTCTGGAGTTA
CCTCCCATGGATTTTTTTTTCCTTTGGCCTGGGTTTTATAAACAACTTGAACATCATATCATATAGGATAACAAAGGAGGAAGTTAACTT
AATTCACCTCAGACTTCAGCCTAAGATTCAATCAAATTCATCCTTCAGCCTGTCTTGTTTCTTCTTTATGTTTCTTTTACTTATTGCTGC
TAGGATCCTACATAGGATTTCTATAGAAATGTATGAAATTCTGTGGTCACTGCATGTCAGGATTGCACAGTATGTTACAATACAATTTCA
AAGAGAACCCACATTTGTGAGATTTACAGACCAAGGTGTGGTGGAGGAGGTAGAATTGCAGATCAGATAAAAAGTGAGCTTACACTTGAA
CTTAGTTATTCACTGTGACCTAAATTTAGTCCTATTGTAATATGTGCCTGTCACAACACAAATACCCCTCTTGAAAGAGATTTACTCATC
TATCCAAGCACTTAATTTGGAAATTTTATTGTCCTATTGCAAAATGAAACAAAATTAAAAGTGGCCTCGAGTACTTGGTAAGTTACTTAA
AATTTTTACAAAAATATCCCACTCAATGCCAAATCTTTCAGTCCTCAAAGGCATTTAAGTCCAATAGTCATGCTTTAAATATGGCTTTAA
ATTATGCCACCAAAATGGTGCACTTCACAGATTCACCAGACTGTAGCATCATAAAGTTAATTTACAGTTTTTACAACATTGCTTCTACAT
TCTTACTGGTTTACATTAAAATCCTTTAAGCCAAAAGGAAGCTTGCTCTATGGATTTAAATGCAAACTTCATTTACCAGTGCAGGAAGTC
TCATAAAACTCAGATGTACTCCCACAAAAATTTTATTGGCCTTTTTGTAAGAGATGAAAAAGAATTGACACAGTTCTCTTTAAAGAGAAG
AACTTTTTTATTATTATTTTTATCTCCAACTGCAGGTGGTGTCTTTTGCCAAGGTCTCTGTATTTTTCTTTCAGTTGTCTTTGGGAGGGG
ATGTTAAGTCAAATCACTAAAACAGGGTTCTCTTTGGATTAAAAGTTCTGGATTTATTGCAACTATTTTCCTTGAGAAACATTCTCAGCA
TCAGGATTGATAAACAAATGTAGATGATTAAAATAGGATAATTGGTTTTAGATAATATCTTCTACTGCCAAACTTCTGGCAAATTTACCT
GTGAATTTCAAAATGTTATAAAATCTCTTGATATGCTTTTGTTTTTCCTTTTAGCCATTTTCTCTTCAATTTCTTAGTCCCTCTGCCCTC
TGTAAATGTGTTGAGTGATATAGCTATCAGATGTATTGAAGGCAAAGTTCTCGCAGAGGTCTCTGTTCCAGCTCTGTAAAGGTCACAGGA
ATCGTGAAGGAGCTGAGAAATCTTCCTCTCCGGCCCACTGTCTGTGGCCCATTGTCATTGTTTCCTCATGAAACATTGCAGAGTTTGAAT
CCTCAGTAACTCTCATTGACTGGATTAGAGGTGATGGCCACAGCAAATGGGAGAGCAAAATGTTGGCCTACAGAGAATGACACAATTTTA
TTCGCCTTTGGTGTTAGTTGCCATAGTGCTGTATTTGAAAATCGATGCTTTAGCCAAAAGCTGAATGACCACCGTTTCCGTAGTTTCCAC

>22694_22694_5_DHX40-UNC5D_DHX40_chr17_57644155_ENST00000251241_UNC5D_chr8_35406810_ENST00000453357_length(amino acids)=1012AA_BP=93
MSRFPAVAGRAPRRQEEGERSRDLQEERLSAVCIADREEKGCTSQEGGTTPTFPIQKQRKKIIQAVRDNSFLIVTGNTGSGKTTQLPKYL
YEAGTDNGEALPESIPSAPGTLPHFIEEPDDAYIIKSNPIALRCKARPAMQIFFKCNGEWVHQNEHVSEETLDESSGLKVREVFINVTRQ
QVEDFHGPEDYWCQCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQGREVPIEGMIVLHCRPPEGVPAAEVEWLKNEEPIDSEQDENIDTR
ADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVNGGWSSWTEWSACNVRCGRGWQKRSRTCTNPAPLNGGAFCEGMSVQKITC
TSLCPVDGSWEVWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQESENCTDGLCILDKKPLHEIKPQSIENASDIALYSGLGAAVV
AVAVLVIGVTLYRRSQSDYGVDVIDSSALTGGFQTFNFKTVRQGNSLLLNSAMQPDLTVSRTYSGPICLQDPLDKELMTESSLFNPLSDI
KVKVQSSFMVSLGVSERAEYHGKNHSRTFPHGNNHSFSTMHPRNKMPYIQNLSSLPTRTELRTTGVFGHLGGRLVMPNTGVSLLIPHGAI
PEENSWEIYMSINQGEPSLQSDGSEVLLSPEVTCGPPDMIVTTPFALTIPHCADVSSEHWNIHLKKRTQQGKWEEVMSVEDESTSCYCLL
DPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQGGQLLEEPKLLHFKGNTFSLQ
ISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQVQTSILESERETITFFAQEDST
FPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQHDGDLDSLACALEEIGRTHTK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DHX40-UNC5D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DHX40-UNC5D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DHX40-UNC5D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource