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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DHX8-FMO5 (FusionGDB2 ID:22708)

Fusion Gene Summary for DHX8-FMO5

check button Fusion gene summary
Fusion gene informationFusion gene name: DHX8-FMO5
Fusion gene ID: 22708
HgeneTgene
Gene symbol

DHX8

FMO5

Gene ID

1659

2330

Gene nameDEAH-box helicase 8flavin containing dimethylaniline monoxygenase 5
SynonymsDDX8|Dhr2|HRH1|PRP22|PRPF22-
Cytomap

17q21.31

1q21.1

Type of geneprotein-codingprotein-coding
DescriptionATP-dependent RNA helicase DHX8DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase)DEAH (Asp-Glu-Ala-His) box polypeptide 8DEAH box protein 8RNA helicase HRH1dimethylaniline monooxygenase [N-oxide-forming] 5FMO 5dimethylaniline oxidase 5flavin containing monooxygenase 5hepatic flavin-containing monooxygenase 5
Modification date2020032220200327
UniProtAcc

Q14562

P49326

Ensembl transtripts involved in fusion geneENST00000262415, ENST00000540306, 
ENST00000465173, ENST00000254090, 
ENST00000369272, ENST00000441068, 
Fusion gene scores* DoF score17 X 12 X 11=22443 X 3 X 3=27
# samples 183
** MAII scorelog2(18/2244*10)=-3.64000386427912
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DHX8 [Title/Abstract] AND FMO5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDHX8(41561553)-FMO5(146661828), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDHX8

GO:0000398

mRNA splicing, via spliceosome

28076346


check buttonFusion gene breakpoints across DHX8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FMO5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-UY-A9PD-01ADHX8chr17

41561553

-FMO5chr1

146661828

-
ChimerDB4BLCATCGA-UY-A9PD-01ADHX8chr17

41561553

+FMO5chr1

146661828

-


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Fusion Gene ORF analysis for DHX8-FMO5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262415ENST00000465173DHX8chr17

41561553

+FMO5chr1

146661828

-
5CDS-intronENST00000540306ENST00000465173DHX8chr17

41561553

+FMO5chr1

146661828

-
In-frameENST00000262415ENST00000254090DHX8chr17

41561553

+FMO5chr1

146661828

-
In-frameENST00000262415ENST00000369272DHX8chr17

41561553

+FMO5chr1

146661828

-
In-frameENST00000262415ENST00000441068DHX8chr17

41561553

+FMO5chr1

146661828

-
In-frameENST00000540306ENST00000254090DHX8chr17

41561553

+FMO5chr1

146661828

-
In-frameENST00000540306ENST00000369272DHX8chr17

41561553

+FMO5chr1

146661828

-
In-frameENST00000540306ENST00000441068DHX8chr17

41561553

+FMO5chr1

146661828

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000540306DHX8chr1741561553+ENST00000441068FMO5chr1146661828-62222330434134
ENST00000540306DHX8chr1741561553+ENST00000254090FMO5chr1146661828-128322330641203
ENST00000540306DHX8chr1741561553+ENST00000369272FMO5chr1146661828-128122330641203
ENST00000262415DHX8chr1741561553+ENST00000441068FMO5chr1146661828-61922027431134
ENST00000262415DHX8chr1741561553+ENST00000254090FMO5chr1146661828-128022027638203
ENST00000262415DHX8chr1741561553+ENST00000369272FMO5chr1146661828-127822027638203

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000540306ENST00000441068DHX8chr1741561553+FMO5chr1146661828-0.0227972230.97720283
ENST00000540306ENST00000254090DHX8chr1741561553+FMO5chr1146661828-0.0006724220.99932766
ENST00000540306ENST00000369272DHX8chr1741561553+FMO5chr1146661828-0.0006782130.9993218
ENST00000262415ENST00000441068DHX8chr1741561553+FMO5chr1146661828-0.0232492440.97675073
ENST00000262415ENST00000254090DHX8chr1741561553+FMO5chr1146661828-0.000694240.9993057
ENST00000262415ENST00000369272DHX8chr1741561553+FMO5chr1146661828-0.0006975250.9993025

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Fusion Genomic Features for DHX8-FMO5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DHX8-FMO5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:41561553/chr1:146661828)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DHX8

Q14562

FMO5

P49326

FUNCTION: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:8608946}.FUNCTION: Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters (PubMed:28783300, PubMed:26771671, PubMed:20947616). Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive (PubMed:26771671, PubMed:7872795). In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable) (PubMed:7872795). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline (PubMed:28783300). Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity (PubMed:26771671). Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (By similarity). {ECO:0000250|UniProtKB:P97872, ECO:0000269|PubMed:20947616, ECO:0000269|PubMed:26771671, ECO:0000269|PubMed:28783300, ECO:0000269|PubMed:7872795, ECO:0000305|PubMed:26771671}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFMO5chr17:41561553chr1:146661828ENST0000025409069513_533394534.0TransmembraneHelical
TgeneFMO5chr17:41561553chr1:146661828ENST0000036927247513_533276437.3333333333333TransmembraneHelical
TgeneFMO5chr17:41561553chr1:146661828ENST0000044106869513_533394465.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDHX8chr17:41561553chr1:146661828ENST00000262415+123172_175491221.0Compositional biasNote=Poly-Lys
HgeneDHX8chr17:41561553chr1:146661828ENST00000262415+123176_228491221.0Compositional biasNote=Arg/Ser-rich (RS domain)
HgeneDHX8chr17:41561553chr1:146661828ENST00000262415+123265_336491221.0DomainS1 motif
HgeneDHX8chr17:41561553chr1:146661828ENST00000262415+123575_738491221.0DomainHelicase ATP-binding
HgeneDHX8chr17:41561553chr1:146661828ENST00000262415+123756_936491221.0DomainHelicase C-terminal
HgeneDHX8chr17:41561553chr1:146661828ENST00000262415+123685_688491221.0MotifNote=DEAH box
HgeneDHX8chr17:41561553chr1:146661828ENST00000262415+123588_595491221.0Nucleotide bindingATP
TgeneFMO5chr17:41561553chr1:146661828ENST000002540906910_14394534.0Nucleotide bindingFAD
TgeneFMO5chr17:41561553chr1:146661828ENST0000025409069196_199394534.0Nucleotide bindingNADP
TgeneFMO5chr17:41561553chr1:146661828ENST000002540906941_42394534.0Nucleotide bindingFAD
TgeneFMO5chr17:41561553chr1:146661828ENST000002540906962_63394534.0Nucleotide bindingFAD
TgeneFMO5chr17:41561553chr1:146661828ENST000003692724710_14276437.3333333333333Nucleotide bindingFAD
TgeneFMO5chr17:41561553chr1:146661828ENST0000036927247196_199276437.3333333333333Nucleotide bindingNADP
TgeneFMO5chr17:41561553chr1:146661828ENST000003692724741_42276437.3333333333333Nucleotide bindingFAD
TgeneFMO5chr17:41561553chr1:146661828ENST000003692724762_63276437.3333333333333Nucleotide bindingFAD
TgeneFMO5chr17:41561553chr1:146661828ENST000004410686910_14394465.0Nucleotide bindingFAD
TgeneFMO5chr17:41561553chr1:146661828ENST0000044106869196_199394465.0Nucleotide bindingNADP
TgeneFMO5chr17:41561553chr1:146661828ENST000004410686941_42394465.0Nucleotide bindingFAD
TgeneFMO5chr17:41561553chr1:146661828ENST000004410686962_63394465.0Nucleotide bindingFAD


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Fusion Gene Sequence for DHX8-FMO5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22708_22708_1_DHX8-FMO5_DHX8_chr17_41561553_ENST00000262415_FMO5_chr1_146661828_ENST00000254090_length(transcript)=1280nt_BP=220nt
GAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTAGCC
ATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGCACT
GAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGGTCTAAAGACATTGCCCTCACAGAGTGAAATGATGGCAGAAATATCTAAA
GCTCAAGAGGAAATTGACAAAAGGTATGTGGAGAGCCAACGCCATACCATTCAGGGAGACTACATAGATACCATGGAAGAGCTTGCTGAT
TTGGTGGGGGTCAGGCCCAATCTGCTGTCTCTGGCCTTCACTGACCCCAAGCTGGCATTACACTTATTACTGGGACCCTGCACTCCAATC
CACTATCGTGTACAGGGCCCTGGAAAGTGGGATGGGGCTCGAAAAGCTATCCTCACCACAGATGATCGCATCAGGAAGCCTCTGATGACA
AGAGTAGTTGAAAGGAGTAGTTCTATGACTTCAACAATGACAATAGGCAAGTTTATGCTAGCTCTTGCCTTCTTTGCTATAATTATAGCT
TACTTCTAGTTGTCCTATTGTCACTGCCCTGTTTTTCATTGGGAAGCTTATCTACAGATGCCTTCAGAATCTGACGAGATTGACTCTCAG
TTTCATATTGCCCAGAAATCTACTTTAATGTCTCTTTCGAAAGCATTAATTCACTTTCCTTTTTCCTACAATGAAACCTGTTTTCCATTT
GTATTAACTCATCTCCCTTCCACTCATGATCCGTCACTCTTCCTTGTGGTAATCCCTAGACTGGGAGCTCAGGTACTCTTTTAGTCATCT
TTGTATGTCTTTAGCAGAGTTCTTGACATGTGGTAGGTGCTTAATAAATGTTTGTTGTTTATCAAATTTTATGGTAGGGAGAGTAAGTCA
GCATCGGTATAAAATCGCTTACTCCACGTAACTCTTCTTCTGATAGGGTTTGATTTTCTATTAGAAGCTCAATTTTAGTTTTTTTTCATA
TTATAACTAAATATGTTTCCTGAGAGATAAGAGAAATAATGTTCCTACAATAGTTGTATGTATCTAAGATAAGACATATAGATGCTTAAG
ACATTTTGTTTCACTTGCTATTCACTAGTGTACTTGAAACATGGTCATTTTTAGCCCTTTTCCTTAGGAACCATGTCTTTATTTTCTCAA

>22708_22708_1_DHX8-FMO5_DHX8_chr17_41561553_ENST00000262415_FMO5_chr1_146661828_ENST00000254090_length(amino acids)=203AA_BP=63
MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLGLKTLPSQSEMMAEISKAQEEIDKRY
VESQRHTIQGDYIDTMEELADLVGVRPNLLSLAFTDPKLALHLLLGPCTPIHYRVQGPGKWDGARKAILTTDDRIRKPLMTRVVERSSSM

--------------------------------------------------------------
>22708_22708_2_DHX8-FMO5_DHX8_chr17_41561553_ENST00000262415_FMO5_chr1_146661828_ENST00000369272_length(transcript)=1278nt_BP=220nt
GAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTAGCC
ATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGCACT
GAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGGTCTAAAGACATTGCCCTCACAGAGTGAAATGATGGCAGAAATATCTAAA
GCTCAAGAGGAAATTGACAAAAGGTATGTGGAGAGCCAACGCCATACCATTCAGGGAGACTACATAGATACCATGGAAGAGCTTGCTGAT
TTGGTGGGGGTCAGGCCCAATCTGCTGTCTCTGGCCTTCACTGACCCCAAGCTGGCATTACACTTATTACTGGGACCCTGCACTCCAATC
CACTATCGTGTACAGGGCCCTGGAAAGTGGGATGGGGCTCGAAAAGCTATCCTCACCACAGATGATCGCATCAGGAAGCCTCTGATGACA
AGAGTAGTTGAAAGGAGTAGTTCTATGACTTCAACAATGACAATAGGCAAGTTTATGCTAGCTCTTGCCTTCTTTGCTATAATTATAGCT
TACTTCTAGTTGTCCTATTGTCACTGCCCTGTTTTTCATTGGGAAGCTTATCTACAGATGCCTTCAGAATCTGACGAGATTGACTCTCAG
TTTCATATTGCCCAGAAATCTACTTTAATGTCTCTTTCGAAAGCATTAATTCACTTTCCTTTTTCCTACAATGAAACCTGTTTTCCATTT
GTATTAACTCATCTCCCTTCCACTCATGATCCGTCACTCTTCCTTGTGGTAATCCCTAGACTGGGAGCTCAGGTACTCTTTTAGTCATCT
TTGTATGTCTTTAGCAGAGTTCTTGACATGTGGTAGGTGCTTAATAAATGTTTGTTGTTTATCAAATTTTATGGTAGGGAGAGTAAGTCA
GCATCGGTATAAAATCGCTTACTCCACGTAACTCTTCTTCTGATAGGGTTTGATTTTCTATTAGAAGCTCAATTTTAGTTTTTTTTCATA
TTATAACTAAATATGTTTCCTGAGAGATAAGAGAAATAATGTTCCTACAATAGTTGTATGTATCTAAGATAAGACATATAGATGCTTAAG
ACATTTTGTTTCACTTGCTATTCACTAGTGTACTTGAAACATGGTCATTTTTAGCCCTTTTCCTTAGGAACCATGTCTTTATTTTCTCAA

>22708_22708_2_DHX8-FMO5_DHX8_chr17_41561553_ENST00000262415_FMO5_chr1_146661828_ENST00000369272_length(amino acids)=203AA_BP=63
MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLGLKTLPSQSEMMAEISKAQEEIDKRY
VESQRHTIQGDYIDTMEELADLVGVRPNLLSLAFTDPKLALHLLLGPCTPIHYRVQGPGKWDGARKAILTTDDRIRKPLMTRVVERSSSM

--------------------------------------------------------------
>22708_22708_3_DHX8-FMO5_DHX8_chr17_41561553_ENST00000262415_FMO5_chr1_146661828_ENST00000441068_length(transcript)=619nt_BP=220nt
GAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTAGCC
ATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGCACT
GAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGGTCTAAAGACATTGCCCTCACAGAGTGAAATGATGGCAGAAATATCTAAA
GCTCAAGAGGAAATTGACAAAAGTCTAACCATGAGAAAAACATCAGACAAACCCAAGTTGAAGAATATTCTACAAATACCTGACTACCTC
AAAACTGTCAAGATCATCAACAAAGAAAGTCTGAGAAATTGTCCCGGAATAAAGGGGCCTAAGGAGACATAACATCTAAATGTAATGTAG
TATCCTGGATGGACTCCTGCAACAGAAAAAGAACTTTAAGTAAAAATTAAGGGAATATTAATAAAGTATGCATTTTGGTTAATAATGTAT

>22708_22708_3_DHX8-FMO5_DHX8_chr17_41561553_ENST00000262415_FMO5_chr1_146661828_ENST00000441068_length(amino acids)=134AA_BP=63
MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLGLKTLPSQSEMMAEISKAQEEIDKSL

--------------------------------------------------------------
>22708_22708_4_DHX8-FMO5_DHX8_chr17_41561553_ENST00000540306_FMO5_chr1_146661828_ENST00000254090_length(transcript)=1283nt_BP=223nt
AGTGAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTA
GCCATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGC
ACTGAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGGTCTAAAGACATTGCCCTCACAGAGTGAAATGATGGCAGAAATATCT
AAAGCTCAAGAGGAAATTGACAAAAGGTATGTGGAGAGCCAACGCCATACCATTCAGGGAGACTACATAGATACCATGGAAGAGCTTGCT
GATTTGGTGGGGGTCAGGCCCAATCTGCTGTCTCTGGCCTTCACTGACCCCAAGCTGGCATTACACTTATTACTGGGACCCTGCACTCCA
ATCCACTATCGTGTACAGGGCCCTGGAAAGTGGGATGGGGCTCGAAAAGCTATCCTCACCACAGATGATCGCATCAGGAAGCCTCTGATG
ACAAGAGTAGTTGAAAGGAGTAGTTCTATGACTTCAACAATGACAATAGGCAAGTTTATGCTAGCTCTTGCCTTCTTTGCTATAATTATA
GCTTACTTCTAGTTGTCCTATTGTCACTGCCCTGTTTTTCATTGGGAAGCTTATCTACAGATGCCTTCAGAATCTGACGAGATTGACTCT
CAGTTTCATATTGCCCAGAAATCTACTTTAATGTCTCTTTCGAAAGCATTAATTCACTTTCCTTTTTCCTACAATGAAACCTGTTTTCCA
TTTGTATTAACTCATCTCCCTTCCACTCATGATCCGTCACTCTTCCTTGTGGTAATCCCTAGACTGGGAGCTCAGGTACTCTTTTAGTCA
TCTTTGTATGTCTTTAGCAGAGTTCTTGACATGTGGTAGGTGCTTAATAAATGTTTGTTGTTTATCAAATTTTATGGTAGGGAGAGTAAG
TCAGCATCGGTATAAAATCGCTTACTCCACGTAACTCTTCTTCTGATAGGGTTTGATTTTCTATTAGAAGCTCAATTTTAGTTTTTTTTC
ATATTATAACTAAATATGTTTCCTGAGAGATAAGAGAAATAATGTTCCTACAATAGTTGTATGTATCTAAGATAAGACATATAGATGCTT
AAGACATTTTGTTTCACTTGCTATTCACTAGTGTACTTGAAACATGGTCATTTTTAGCCCTTTTCCTTAGGAACCATGTCTTTATTTTCT

>22708_22708_4_DHX8-FMO5_DHX8_chr17_41561553_ENST00000540306_FMO5_chr1_146661828_ENST00000254090_length(amino acids)=203AA_BP=63
MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLGLKTLPSQSEMMAEISKAQEEIDKRY
VESQRHTIQGDYIDTMEELADLVGVRPNLLSLAFTDPKLALHLLLGPCTPIHYRVQGPGKWDGARKAILTTDDRIRKPLMTRVVERSSSM

--------------------------------------------------------------
>22708_22708_5_DHX8-FMO5_DHX8_chr17_41561553_ENST00000540306_FMO5_chr1_146661828_ENST00000369272_length(transcript)=1281nt_BP=223nt
AGTGAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTA
GCCATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGC
ACTGAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGGTCTAAAGACATTGCCCTCACAGAGTGAAATGATGGCAGAAATATCT
AAAGCTCAAGAGGAAATTGACAAAAGGTATGTGGAGAGCCAACGCCATACCATTCAGGGAGACTACATAGATACCATGGAAGAGCTTGCT
GATTTGGTGGGGGTCAGGCCCAATCTGCTGTCTCTGGCCTTCACTGACCCCAAGCTGGCATTACACTTATTACTGGGACCCTGCACTCCA
ATCCACTATCGTGTACAGGGCCCTGGAAAGTGGGATGGGGCTCGAAAAGCTATCCTCACCACAGATGATCGCATCAGGAAGCCTCTGATG
ACAAGAGTAGTTGAAAGGAGTAGTTCTATGACTTCAACAATGACAATAGGCAAGTTTATGCTAGCTCTTGCCTTCTTTGCTATAATTATA
GCTTACTTCTAGTTGTCCTATTGTCACTGCCCTGTTTTTCATTGGGAAGCTTATCTACAGATGCCTTCAGAATCTGACGAGATTGACTCT
CAGTTTCATATTGCCCAGAAATCTACTTTAATGTCTCTTTCGAAAGCATTAATTCACTTTCCTTTTTCCTACAATGAAACCTGTTTTCCA
TTTGTATTAACTCATCTCCCTTCCACTCATGATCCGTCACTCTTCCTTGTGGTAATCCCTAGACTGGGAGCTCAGGTACTCTTTTAGTCA
TCTTTGTATGTCTTTAGCAGAGTTCTTGACATGTGGTAGGTGCTTAATAAATGTTTGTTGTTTATCAAATTTTATGGTAGGGAGAGTAAG
TCAGCATCGGTATAAAATCGCTTACTCCACGTAACTCTTCTTCTGATAGGGTTTGATTTTCTATTAGAAGCTCAATTTTAGTTTTTTTTC
ATATTATAACTAAATATGTTTCCTGAGAGATAAGAGAAATAATGTTCCTACAATAGTTGTATGTATCTAAGATAAGACATATAGATGCTT
AAGACATTTTGTTTCACTTGCTATTCACTAGTGTACTTGAAACATGGTCATTTTTAGCCCTTTTCCTTAGGAACCATGTCTTTATTTTCT

>22708_22708_5_DHX8-FMO5_DHX8_chr17_41561553_ENST00000540306_FMO5_chr1_146661828_ENST00000369272_length(amino acids)=203AA_BP=63
MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLGLKTLPSQSEMMAEISKAQEEIDKRY
VESQRHTIQGDYIDTMEELADLVGVRPNLLSLAFTDPKLALHLLLGPCTPIHYRVQGPGKWDGARKAILTTDDRIRKPLMTRVVERSSSM

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>22708_22708_6_DHX8-FMO5_DHX8_chr17_41561553_ENST00000540306_FMO5_chr1_146661828_ENST00000441068_length(transcript)=622nt_BP=223nt
AGTGAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTA
GCCATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGC
ACTGAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGGTCTAAAGACATTGCCCTCACAGAGTGAAATGATGGCAGAAATATCT
AAAGCTCAAGAGGAAATTGACAAAAGTCTAACCATGAGAAAAACATCAGACAAACCCAAGTTGAAGAATATTCTACAAATACCTGACTAC
CTCAAAACTGTCAAGATCATCAACAAAGAAAGTCTGAGAAATTGTCCCGGAATAAAGGGGCCTAAGGAGACATAACATCTAAATGTAATG
TAGTATCCTGGATGGACTCCTGCAACAGAAAAAGAACTTTAAGTAAAAATTAAGGGAATATTAATAAAGTATGCATTTTGGTTAATAATG

>22708_22708_6_DHX8-FMO5_DHX8_chr17_41561553_ENST00000540306_FMO5_chr1_146661828_ENST00000441068_length(amino acids)=134AA_BP=63
MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLGLKTLPSQSEMMAEISKAQEEIDKSL

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Fusion Gene PPI Analysis for DHX8-FMO5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DHX8-FMO5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DHX8-FMO5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource