Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DIAPH1-BRIX1 (FusionGDB2 ID:22739)

Fusion Gene Summary for DIAPH1-BRIX1

Fusion gene summary

Fusion gene information	Fusion gene name: DIAPH1-BRIX1
	Fusion gene ID: 22739
		Hgene	Tgene
	Gene symbol	DIAPH1	BRIX1
	Gene ID	1729	55299
	Gene name	diaphanous related formin 1	biogenesis of ribosomes BRX1
	Synonyms	DFNA1\|DIA1\|DRF1\|LFHL1\|SCBMS\|hDIA1	BRIX\|BXDC2
	Cytomap	5q31.3	5p13.2
	Type of gene	protein-coding	protein-coding
	Description	protein diaphanous homolog 1	ribosome biogenesis protein BRX1 homologBRX1, biogenesis of ribosomes, homologbrix domain containing 2brix domain-containing protein 2
	Modification date	20200313	20200313
	UniProtAcc	O60610	Q8TDN6
	Ensembl transtripts involved in fusion gene	ENST00000253811, ENST00000389054, ENST00000389057, ENST00000398557, ENST00000398562, ENST00000398566, ENST00000518047, ENST00000520569, ENST00000494967,	ENST00000506023, ENST00000336767,
Fusion gene scores	* DoF score	6 X 6 X 5=180	2 X 2 X 2=8
	# samples	7	2
	** MAII score	log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: DIAPH1 [Title/Abstract] AND BRIX1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DIAPH1(140963691)-BRIX1(34924952), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across DIAPH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BRIX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-EW-A1P4-01A	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+

Top

Fusion Gene ORF analysis for DIAPH1-BRIX1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000253811	ENST00000506023	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+
5CDS-3UTR	ENST00000389054	ENST00000506023	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+
5CDS-3UTR	ENST00000389057	ENST00000506023	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+
5CDS-3UTR	ENST00000398557	ENST00000506023	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+
5CDS-3UTR	ENST00000398562	ENST00000506023	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+
5CDS-3UTR	ENST00000398566	ENST00000506023	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+
5CDS-3UTR	ENST00000518047	ENST00000506023	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+
5CDS-3UTR	ENST00000520569	ENST00000506023	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+
In-frame	ENST00000253811	ENST00000336767	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+
In-frame	ENST00000389054	ENST00000336767	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+
In-frame	ENST00000389057	ENST00000336767	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+
In-frame	ENST00000398557	ENST00000336767	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+
In-frame	ENST00000398562	ENST00000336767	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+
In-frame	ENST00000398566	ENST00000336767	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+
In-frame	ENST00000518047	ENST00000336767	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+
In-frame	ENST00000520569	ENST00000336767	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+
intron-3CDS	ENST00000494967	ENST00000336767	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+
intron-3UTR	ENST00000494967	ENST00000506023	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000389054	DIAPH1	chr5	140963691	-	ENST00000336767	BRIX1	chr5	34924952	+	1443	543	87	941	284
ENST00000520569	DIAPH1	chr5	140963691	-	ENST00000336767	BRIX1	chr5	34924952	+	1158	258	0	656	218
ENST00000253811	DIAPH1	chr5	140963691	-	ENST00000336767	BRIX1	chr5	34924952	+	1443	543	87	941	284
ENST00000398566	DIAPH1	chr5	140963691	-	ENST00000336767	BRIX1	chr5	34924952	+	1416	516	87	914	275
ENST00000398562	DIAPH1	chr5	140963691	-	ENST00000336767	BRIX1	chr5	34924952	+	1416	516	87	914	275
ENST00000398557	DIAPH1	chr5	140963691	-	ENST00000336767	BRIX1	chr5	34924952	+	1443	543	87	941	284
ENST00000389057	DIAPH1	chr5	140963691	-	ENST00000336767	BRIX1	chr5	34924952	+	1416	516	87	914	275
ENST00000518047	DIAPH1	chr5	140963691	-	ENST00000336767	BRIX1	chr5	34924952	+	1275	375	0	773	257

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000389054	ENST00000336767	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+	0.003282598	0.9967174
ENST00000520569	ENST00000336767	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+	0.004748164	0.9952518
ENST00000253811	ENST00000336767	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+	0.003282598	0.9967174
ENST00000398566	ENST00000336767	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+	0.002986233	0.9970138
ENST00000398562	ENST00000336767	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+	0.002986233	0.9970138
ENST00000398557	ENST00000336767	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+	0.003282598	0.9967174
ENST00000389057	ENST00000336767	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+	0.002986233	0.9970138
ENST00000518047	ENST00000336767	DIAPH1	chr5	140963691	-	BRIX1	chr5	34924952	+	0.002243735	0.9977563

Top

Fusion Genomic Features for DIAPH1-BRIX1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
DIAPH1	chr5	140963690	-	BRIX1	chr5	34924951	+	8.62E-07	0.99999917
DIAPH1	chr5	140963690	-	BRIX1	chr5	34924951	+	8.62E-07	0.99999917

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for DIAPH1-BRIX1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:140963691/chr5:34924952)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DIAPH1 O60610	BRIX1 Q8TDN6
FUNCTION: Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells (PubMed:20937854, PubMed:21834987, PubMed:26912466). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854, PubMed:21834987). It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (PubMed:20937854, PubMed:21834987). In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854, PubMed:21834987). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity). {ECO:0000250\|UniProtKB:O08808, ECO:0000269\|PubMed:20937854, ECO:0000269\|PubMed:21834987, ECO:0000269\|PubMed:24781755, ECO:0000269\|PubMed:26912466}.	FUNCTION: Required for biogenesis of the 60S ribosomal subunit.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DIAPH1

chr5:140963691

chr5:34924952

ENST00000389057

1039_1196

125

1264.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DIAPH1

chr5:140963691

chr5:34924952

ENST00000389057

468_572

125

1264.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DIAPH1

chr5:140963691

chr5:34924952

ENST00000398557

1039_1196

134

1273.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DIAPH1

chr5:140963691

chr5:34924952

ENST00000398557

468_572

134

1273.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DIAPH1

chr5:140963691

chr5:34924952

ENST00000389057

1213_1216

125

1264.0

Compositional bias

Note=Arg/Lys-rich (basic)

Hgene

DIAPH1

chr5:140963691

chr5:34924952

ENST00000398557

1213_1216

134

1273.0

Compositional bias

Note=Arg/Lys-rich (basic)

Hgene

DIAPH1

chr5:140963691

chr5:34924952

ENST00000389057

1194_1222

125

1264.0

Domain

DAD

Hgene

DIAPH1

chr5:140963691

chr5:34924952

ENST00000389057

583_764

125

1264.0

Domain

Note=FH1

Hgene

DIAPH1

chr5:140963691

chr5:34924952

ENST00000389057

769_1171

125

1264.0

Domain

FH2

Hgene

DIAPH1

chr5:140963691

chr5:34924952

ENST00000389057

84_449

125

1264.0

Domain

GBD/FH3

Hgene

DIAPH1

chr5:140963691

chr5:34924952

ENST00000398557

1194_1222

134

1273.0

Domain

DAD

Hgene

DIAPH1

chr5:140963691

chr5:34924952

ENST00000398557

583_764

134

1273.0

Domain

Note=FH1

Hgene

DIAPH1

chr5:140963691

chr5:34924952

ENST00000398557

769_1171

134

1273.0

Domain

FH2

Hgene

DIAPH1

chr5:140963691

chr5:34924952

ENST00000398557

84_449

134

1273.0

Domain

GBD/FH3

Tgene

BRIX1

chr5:140963691

chr5:34924952

ENST00000336767

60_249

221

354.0

Domain

Brix

Top

Fusion Gene Sequence for DIAPH1-BRIX1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>22739_22739_1_DIAPH1-BRIX1_DIAPH1_chr5_140963691_ENST00000253811_BRIX1_chr5_34924952_ENST00000336767_length(transcript)=1443nt_BP=543nt
ATTCATGAGGCGCGCGCAGCCCGGCATGCTAATGAGGCGGGGCGCGGCGGCTGGCTAAAGAGCGACTGGGCGGCGGCGGGCGCGGAGCTG
CCAGGCGGGAGCGGCGTAGGCGCGGGGTCGCCGGCCAGCGTGAACCGGGACATGGAGCCGCCCGGCGGGAGCCTGGGGCCCGGCCGCGGG
ACCCGGGACAAGAAGAAGGGCCGGAGCCCAGATGAGCTGCCCTCGGCGGGCGGCGACGGCGGCAAATCTAAGAAATTTACTCTGAAGCGG
CTCATGGCAGATGAGCTGGAGAGATTTACCAGCATGAGAATTAAGAAGGAGAAGGAAAAGCCCAATTCTGCTCATAGAAATTCTTCTGCA
TCATATGGGGATGATCCCACAGCACAGTCATTGCAAGATGTTTCAGATGAACAAGTGCTGGTTCTCTTTGAACAGATGCTGCTGGATATG
AACCTGAATGAGGAGAAACAGCAACCTTTGAGGGAGAAGGACATCATCATCAAGAGGGAGATGGTGTCCCAATACTTGTACACCTCCAAG
GCTATCATAGAAGAAGATGCTGCTCTTGTAGAAATAGGACCTCGTTTTGTCTTAAATCTCATAAAGATTTTCCAGGGAAGTTTTGGAGGA
CCAACTTTATATGAAAATCCTCACTACCAGTCACCAAACATGCATCGGCGTGTCATAAGATCCATCACAGCTGCAAAATACAGAGAGAAA
CAGCAAGTGAAAGATGTGCAAAAACTGAGAAAGAAAGAGCCGAAGACTCTTCTTCCACATGATCCCACTGCAGATGTTTTTGTAACACCA
GCTGAGGAGAAACCAATAGAAATACAGTGGGTAAAACCAGAGCCAAAAGTTGATTTGAAAGCAAGAAAGAAACGGATTTACAAAAGGCAA
AGAAAAATGAAACAGAGGATGGACAGTGGGAAAACAAAATAAGTCAATGGAAACCTGATTTGTTTTTCAGTTACTTTATATTTATTTTGT
ATTCAATGTGTAAATACTTTTATTATCTAATACTATCTTACGTCTAATTAGTGTAGCATTTACAAGAAAGAAAAATTAAGATCTTAAAAT
CAGTGATTATCTTTTTCTAAATAAAATATCACCAGAATTCATCAGTTAATTTCTGATTTCTTTTTGAAGTTTGTGTTGCTAAAAATGTAG
CACACTTAATGTAGCCTGTTCTCTTGGGTTGGAATTTTTGGTTTAGCAAAGCTGAAATTCAGACATTTATTAGGTCATATTATTTGTAAA
AGCATTCAACACTTCAAGAGCATCGGTTGTGGATGGTAAAGTAGGAGTAGACTGGTAGAAAGGAAGGCATCTCACTGAAGTTTACTCAGT
CATCAGTTAATGAAGCCATGGAAGAACCAACCCCTGATCTGTCACTTCAAAAAAGAGTATATTAAAATGTTGAGGTTTTGAGAATCAAAT

>22739_22739_1_DIAPH1-BRIX1_DIAPH1_chr5_140963691_ENST00000253811_BRIX1_chr5_34924952_ENST00000336767_length(amino acids)=284AA_BP=152
MPGGSGVGAGSPASVNRDMEPPGGSLGPGRGTRDKKKGRSPDELPSAGGDGGKSKKFTLKRLMADELERFTSMRIKKEKEKPNSAHRNSS
ASYGDDPTAQSLQDVSDEQVLVLFEQMLLDMNLNEEKQQPLREKDIIIKREMVSQYLYTSKAIIEEDAALVEIGPRFVLNLIKIFQGSFG
GPTLYENPHYQSPNMHRRVIRSITAAKYREKQQVKDVQKLRKKEPKTLLPHDPTADVFVTPAEEKPIEIQWVKPEPKVDLKARKKRIYKR

--------------------------------------------------------------
>22739_22739_2_DIAPH1-BRIX1_DIAPH1_chr5_140963691_ENST00000389054_BRIX1_chr5_34924952_ENST00000336767_length(transcript)=1443nt_BP=543nt
ATTCATGAGGCGCGCGCAGCCCGGCATGCTAATGAGGCGGGGCGCGGCGGCTGGCTAAAGAGCGACTGGGCGGCGGCGGGCGCGGAGCTG
CCAGGCGGGAGCGGCGTAGGCGCGGGGTCGCCGGCCAGCGTGAACCGGGACATGGAGCCGCCCGGCGGGAGCCTGGGGCCCGGCCGCGGG
ACCCGGGACAAGAAGAAGGGCCGGAGCCCAGATGAGCTGCCCTCGGCGGGCGGCGACGGCGGCAAATCTAAGAAATTTACTCTGAAGCGG
CTCATGGCAGATGAGCTGGAGAGATTTACCAGCATGAGAATTAAGAAGGAGAAGGAAAAGCCCAATTCTGCTCATAGAAATTCTTCTGCA
TCATATGGGGATGATCCCACAGCACAGTCATTGCAAGATGTTTCAGATGAACAAGTGCTGGTTCTCTTTGAACAGATGCTGCTGGATATG
AACCTGAATGAGGAGAAACAGCAACCTTTGAGGGAGAAGGACATCATCATCAAGAGGGAGATGGTGTCCCAATACTTGTACACCTCCAAG
GCTATCATAGAAGAAGATGCTGCTCTTGTAGAAATAGGACCTCGTTTTGTCTTAAATCTCATAAAGATTTTCCAGGGAAGTTTTGGAGGA
CCAACTTTATATGAAAATCCTCACTACCAGTCACCAAACATGCATCGGCGTGTCATAAGATCCATCACAGCTGCAAAATACAGAGAGAAA
CAGCAAGTGAAAGATGTGCAAAAACTGAGAAAGAAAGAGCCGAAGACTCTTCTTCCACATGATCCCACTGCAGATGTTTTTGTAACACCA
GCTGAGGAGAAACCAATAGAAATACAGTGGGTAAAACCAGAGCCAAAAGTTGATTTGAAAGCAAGAAAGAAACGGATTTACAAAAGGCAA
AGAAAAATGAAACAGAGGATGGACAGTGGGAAAACAAAATAAGTCAATGGAAACCTGATTTGTTTTTCAGTTACTTTATATTTATTTTGT
ATTCAATGTGTAAATACTTTTATTATCTAATACTATCTTACGTCTAATTAGTGTAGCATTTACAAGAAAGAAAAATTAAGATCTTAAAAT
CAGTGATTATCTTTTTCTAAATAAAATATCACCAGAATTCATCAGTTAATTTCTGATTTCTTTTTGAAGTTTGTGTTGCTAAAAATGTAG
CACACTTAATGTAGCCTGTTCTCTTGGGTTGGAATTTTTGGTTTAGCAAAGCTGAAATTCAGACATTTATTAGGTCATATTATTTGTAAA
AGCATTCAACACTTCAAGAGCATCGGTTGTGGATGGTAAAGTAGGAGTAGACTGGTAGAAAGGAAGGCATCTCACTGAAGTTTACTCAGT
CATCAGTTAATGAAGCCATGGAAGAACCAACCCCTGATCTGTCACTTCAAAAAAGAGTATATTAAAATGTTGAGGTTTTGAGAATCAAAT

>22739_22739_2_DIAPH1-BRIX1_DIAPH1_chr5_140963691_ENST00000389054_BRIX1_chr5_34924952_ENST00000336767_length(amino acids)=284AA_BP=152
MPGGSGVGAGSPASVNRDMEPPGGSLGPGRGTRDKKKGRSPDELPSAGGDGGKSKKFTLKRLMADELERFTSMRIKKEKEKPNSAHRNSS
ASYGDDPTAQSLQDVSDEQVLVLFEQMLLDMNLNEEKQQPLREKDIIIKREMVSQYLYTSKAIIEEDAALVEIGPRFVLNLIKIFQGSFG
GPTLYENPHYQSPNMHRRVIRSITAAKYREKQQVKDVQKLRKKEPKTLLPHDPTADVFVTPAEEKPIEIQWVKPEPKVDLKARKKRIYKR

--------------------------------------------------------------
>22739_22739_3_DIAPH1-BRIX1_DIAPH1_chr5_140963691_ENST00000389057_BRIX1_chr5_34924952_ENST00000336767_length(transcript)=1416nt_BP=516nt
ATTCATGAGGCGCGCGCAGCCCGGCATGCTAATGAGGCGGGGCGCGGCGGCTGGCTAAAGAGCGACTGGGCGGCGGCGGGCGCGGAGCTG
CCAGGCGGGAGCGGCGTAGGCGCGGGGTCGCCGGCCAGCGTGAACCGGGACATGGAGCCGCCCGGCGGGAGCCTGGGGCCCGGCCGCGGG
ACCCGGGACAAGAAGAAGGGCCGGAGCCCAGATGAGCTGCCCTCGGCGGGCGGCGACGGCGGCAAATCTAAGAAATTTCTGGAGAGATTT
ACCAGCATGAGAATTAAGAAGGAGAAGGAAAAGCCCAATTCTGCTCATAGAAATTCTTCTGCATCATATGGGGATGATCCCACAGCACAG
TCATTGCAAGATGTTTCAGATGAACAAGTGCTGGTTCTCTTTGAACAGATGCTGCTGGATATGAACCTGAATGAGGAGAAACAGCAACCT
TTGAGGGAGAAGGACATCATCATCAAGAGGGAGATGGTGTCCCAATACTTGTACACCTCCAAGGCTATCATAGAAGAAGATGCTGCTCTT
GTAGAAATAGGACCTCGTTTTGTCTTAAATCTCATAAAGATTTTCCAGGGAAGTTTTGGAGGACCAACTTTATATGAAAATCCTCACTAC
CAGTCACCAAACATGCATCGGCGTGTCATAAGATCCATCACAGCTGCAAAATACAGAGAGAAACAGCAAGTGAAAGATGTGCAAAAACTG
AGAAAGAAAGAGCCGAAGACTCTTCTTCCACATGATCCCACTGCAGATGTTTTTGTAACACCAGCTGAGGAGAAACCAATAGAAATACAG
TGGGTAAAACCAGAGCCAAAAGTTGATTTGAAAGCAAGAAAGAAACGGATTTACAAAAGGCAAAGAAAAATGAAACAGAGGATGGACAGT
GGGAAAACAAAATAAGTCAATGGAAACCTGATTTGTTTTTCAGTTACTTTATATTTATTTTGTATTCAATGTGTAAATACTTTTATTATC
TAATACTATCTTACGTCTAATTAGTGTAGCATTTACAAGAAAGAAAAATTAAGATCTTAAAATCAGTGATTATCTTTTTCTAAATAAAAT
ATCACCAGAATTCATCAGTTAATTTCTGATTTCTTTTTGAAGTTTGTGTTGCTAAAAATGTAGCACACTTAATGTAGCCTGTTCTCTTGG
GTTGGAATTTTTGGTTTAGCAAAGCTGAAATTCAGACATTTATTAGGTCATATTATTTGTAAAAGCATTCAACACTTCAAGAGCATCGGT
TGTGGATGGTAAAGTAGGAGTAGACTGGTAGAAAGGAAGGCATCTCACTGAAGTTTACTCAGTCATCAGTTAATGAAGCCATGGAAGAAC

>22739_22739_3_DIAPH1-BRIX1_DIAPH1_chr5_140963691_ENST00000389057_BRIX1_chr5_34924952_ENST00000336767_length(amino acids)=275AA_BP=143
MPGGSGVGAGSPASVNRDMEPPGGSLGPGRGTRDKKKGRSPDELPSAGGDGGKSKKFLERFTSMRIKKEKEKPNSAHRNSSASYGDDPTA
QSLQDVSDEQVLVLFEQMLLDMNLNEEKQQPLREKDIIIKREMVSQYLYTSKAIIEEDAALVEIGPRFVLNLIKIFQGSFGGPTLYENPH
YQSPNMHRRVIRSITAAKYREKQQVKDVQKLRKKEPKTLLPHDPTADVFVTPAEEKPIEIQWVKPEPKVDLKARKKRIYKRQRKMKQRMD

--------------------------------------------------------------
>22739_22739_4_DIAPH1-BRIX1_DIAPH1_chr5_140963691_ENST00000398557_BRIX1_chr5_34924952_ENST00000336767_length(transcript)=1443nt_BP=543nt
ATTCATGAGGCGCGCGCAGCCCGGCATGCTAATGAGGCGGGGCGCGGCGGCTGGCTAAAGAGCGACTGGGCGGCGGCGGGCGCGGAGCTG
CCAGGCGGGAGCGGCGTAGGCGCGGGGTCGCCGGCCAGCGTGAACCGGGACATGGAGCCGCCCGGCGGGAGCCTGGGGCCCGGCCGCGGG
ACCCGGGACAAGAAGAAGGGCCGGAGCCCAGATGAGCTGCCCTCGGCGGGCGGCGACGGCGGCAAATCTAAGAAATTTACTCTGAAGCGG
CTCATGGCAGATGAGCTGGAGAGATTTACCAGCATGAGAATTAAGAAGGAGAAGGAAAAGCCCAATTCTGCTCATAGAAATTCTTCTGCA
TCATATGGGGATGATCCCACAGCACAGTCATTGCAAGATGTTTCAGATGAACAAGTGCTGGTTCTCTTTGAACAGATGCTGCTGGATATG
AACCTGAATGAGGAGAAACAGCAACCTTTGAGGGAGAAGGACATCATCATCAAGAGGGAGATGGTGTCCCAATACTTGTACACCTCCAAG
GCTATCATAGAAGAAGATGCTGCTCTTGTAGAAATAGGACCTCGTTTTGTCTTAAATCTCATAAAGATTTTCCAGGGAAGTTTTGGAGGA
CCAACTTTATATGAAAATCCTCACTACCAGTCACCAAACATGCATCGGCGTGTCATAAGATCCATCACAGCTGCAAAATACAGAGAGAAA
CAGCAAGTGAAAGATGTGCAAAAACTGAGAAAGAAAGAGCCGAAGACTCTTCTTCCACATGATCCCACTGCAGATGTTTTTGTAACACCA
GCTGAGGAGAAACCAATAGAAATACAGTGGGTAAAACCAGAGCCAAAAGTTGATTTGAAAGCAAGAAAGAAACGGATTTACAAAAGGCAA
AGAAAAATGAAACAGAGGATGGACAGTGGGAAAACAAAATAAGTCAATGGAAACCTGATTTGTTTTTCAGTTACTTTATATTTATTTTGT
ATTCAATGTGTAAATACTTTTATTATCTAATACTATCTTACGTCTAATTAGTGTAGCATTTACAAGAAAGAAAAATTAAGATCTTAAAAT
CAGTGATTATCTTTTTCTAAATAAAATATCACCAGAATTCATCAGTTAATTTCTGATTTCTTTTTGAAGTTTGTGTTGCTAAAAATGTAG
CACACTTAATGTAGCCTGTTCTCTTGGGTTGGAATTTTTGGTTTAGCAAAGCTGAAATTCAGACATTTATTAGGTCATATTATTTGTAAA
AGCATTCAACACTTCAAGAGCATCGGTTGTGGATGGTAAAGTAGGAGTAGACTGGTAGAAAGGAAGGCATCTCACTGAAGTTTACTCAGT
CATCAGTTAATGAAGCCATGGAAGAACCAACCCCTGATCTGTCACTTCAAAAAAGAGTATATTAAAATGTTGAGGTTTTGAGAATCAAAT

>22739_22739_4_DIAPH1-BRIX1_DIAPH1_chr5_140963691_ENST00000398557_BRIX1_chr5_34924952_ENST00000336767_length(amino acids)=284AA_BP=152
MPGGSGVGAGSPASVNRDMEPPGGSLGPGRGTRDKKKGRSPDELPSAGGDGGKSKKFTLKRLMADELERFTSMRIKKEKEKPNSAHRNSS
ASYGDDPTAQSLQDVSDEQVLVLFEQMLLDMNLNEEKQQPLREKDIIIKREMVSQYLYTSKAIIEEDAALVEIGPRFVLNLIKIFQGSFG
GPTLYENPHYQSPNMHRRVIRSITAAKYREKQQVKDVQKLRKKEPKTLLPHDPTADVFVTPAEEKPIEIQWVKPEPKVDLKARKKRIYKR

--------------------------------------------------------------
>22739_22739_5_DIAPH1-BRIX1_DIAPH1_chr5_140963691_ENST00000398562_BRIX1_chr5_34924952_ENST00000336767_length(transcript)=1416nt_BP=516nt
ATTCATGAGGCGCGCGCAGCCCGGCATGCTAATGAGGCGGGGCGCGGCGGCTGGCTAAAGAGCGACTGGGCGGCGGCGGGCGCGGAGCTG
CCAGGCGGGAGCGGCGTAGGCGCGGGGTCGCCGGCCAGCGTGAACCGGGACATGGAGCCGCCCGGCGGGAGCCTGGGGCCCGGCCGCGGG
ACCCGGGACAAGAAGAAGGGCCGGAGCCCAGATGAGCTGCCCTCGGCGGGCGGCGACGGCGGCAAATCTAAGAAATTTCTGGAGAGATTT
ACCAGCATGAGAATTAAGAAGGAGAAGGAAAAGCCCAATTCTGCTCATAGAAATTCTTCTGCATCATATGGGGATGATCCCACAGCACAG
TCATTGCAAGATGTTTCAGATGAACAAGTGCTGGTTCTCTTTGAACAGATGCTGCTGGATATGAACCTGAATGAGGAGAAACAGCAACCT
TTGAGGGAGAAGGACATCATCATCAAGAGGGAGATGGTGTCCCAATACTTGTACACCTCCAAGGCTATCATAGAAGAAGATGCTGCTCTT
GTAGAAATAGGACCTCGTTTTGTCTTAAATCTCATAAAGATTTTCCAGGGAAGTTTTGGAGGACCAACTTTATATGAAAATCCTCACTAC
CAGTCACCAAACATGCATCGGCGTGTCATAAGATCCATCACAGCTGCAAAATACAGAGAGAAACAGCAAGTGAAAGATGTGCAAAAACTG
AGAAAGAAAGAGCCGAAGACTCTTCTTCCACATGATCCCACTGCAGATGTTTTTGTAACACCAGCTGAGGAGAAACCAATAGAAATACAG
TGGGTAAAACCAGAGCCAAAAGTTGATTTGAAAGCAAGAAAGAAACGGATTTACAAAAGGCAAAGAAAAATGAAACAGAGGATGGACAGT
GGGAAAACAAAATAAGTCAATGGAAACCTGATTTGTTTTTCAGTTACTTTATATTTATTTTGTATTCAATGTGTAAATACTTTTATTATC
TAATACTATCTTACGTCTAATTAGTGTAGCATTTACAAGAAAGAAAAATTAAGATCTTAAAATCAGTGATTATCTTTTTCTAAATAAAAT
ATCACCAGAATTCATCAGTTAATTTCTGATTTCTTTTTGAAGTTTGTGTTGCTAAAAATGTAGCACACTTAATGTAGCCTGTTCTCTTGG
GTTGGAATTTTTGGTTTAGCAAAGCTGAAATTCAGACATTTATTAGGTCATATTATTTGTAAAAGCATTCAACACTTCAAGAGCATCGGT
TGTGGATGGTAAAGTAGGAGTAGACTGGTAGAAAGGAAGGCATCTCACTGAAGTTTACTCAGTCATCAGTTAATGAAGCCATGGAAGAAC

>22739_22739_5_DIAPH1-BRIX1_DIAPH1_chr5_140963691_ENST00000398562_BRIX1_chr5_34924952_ENST00000336767_length(amino acids)=275AA_BP=143
MPGGSGVGAGSPASVNRDMEPPGGSLGPGRGTRDKKKGRSPDELPSAGGDGGKSKKFLERFTSMRIKKEKEKPNSAHRNSSASYGDDPTA
QSLQDVSDEQVLVLFEQMLLDMNLNEEKQQPLREKDIIIKREMVSQYLYTSKAIIEEDAALVEIGPRFVLNLIKIFQGSFGGPTLYENPH
YQSPNMHRRVIRSITAAKYREKQQVKDVQKLRKKEPKTLLPHDPTADVFVTPAEEKPIEIQWVKPEPKVDLKARKKRIYKRQRKMKQRMD

--------------------------------------------------------------
>22739_22739_6_DIAPH1-BRIX1_DIAPH1_chr5_140963691_ENST00000398566_BRIX1_chr5_34924952_ENST00000336767_length(transcript)=1416nt_BP=516nt
ATTCATGAGGCGCGCGCAGCCCGGCATGCTAATGAGGCGGGGCGCGGCGGCTGGCTAAAGAGCGACTGGGCGGCGGCGGGCGCGGAGCTG
CCAGGCGGGAGCGGCGTAGGCGCGGGGTCGCCGGCCAGCGTGAACCGGGACATGGAGCCGCCCGGCGGGAGCCTGGGGCCCGGCCGCGGG
ACCCGGGACAAGAAGAAGGGCCGGAGCCCAGATGAGCTGCCCTCGGCGGGCGGCGACGGCGGCAAATCTAAGAAATTTCTGGAGAGATTT
ACCAGCATGAGAATTAAGAAGGAGAAGGAAAAGCCCAATTCTGCTCATAGAAATTCTTCTGCATCATATGGGGATGATCCCACAGCACAG
TCATTGCAAGATGTTTCAGATGAACAAGTGCTGGTTCTCTTTGAACAGATGCTGCTGGATATGAACCTGAATGAGGAGAAACAGCAACCT
TTGAGGGAGAAGGACATCATCATCAAGAGGGAGATGGTGTCCCAATACTTGTACACCTCCAAGGCTATCATAGAAGAAGATGCTGCTCTT
GTAGAAATAGGACCTCGTTTTGTCTTAAATCTCATAAAGATTTTCCAGGGAAGTTTTGGAGGACCAACTTTATATGAAAATCCTCACTAC
CAGTCACCAAACATGCATCGGCGTGTCATAAGATCCATCACAGCTGCAAAATACAGAGAGAAACAGCAAGTGAAAGATGTGCAAAAACTG
AGAAAGAAAGAGCCGAAGACTCTTCTTCCACATGATCCCACTGCAGATGTTTTTGTAACACCAGCTGAGGAGAAACCAATAGAAATACAG
TGGGTAAAACCAGAGCCAAAAGTTGATTTGAAAGCAAGAAAGAAACGGATTTACAAAAGGCAAAGAAAAATGAAACAGAGGATGGACAGT
GGGAAAACAAAATAAGTCAATGGAAACCTGATTTGTTTTTCAGTTACTTTATATTTATTTTGTATTCAATGTGTAAATACTTTTATTATC
TAATACTATCTTACGTCTAATTAGTGTAGCATTTACAAGAAAGAAAAATTAAGATCTTAAAATCAGTGATTATCTTTTTCTAAATAAAAT
ATCACCAGAATTCATCAGTTAATTTCTGATTTCTTTTTGAAGTTTGTGTTGCTAAAAATGTAGCACACTTAATGTAGCCTGTTCTCTTGG
GTTGGAATTTTTGGTTTAGCAAAGCTGAAATTCAGACATTTATTAGGTCATATTATTTGTAAAAGCATTCAACACTTCAAGAGCATCGGT
TGTGGATGGTAAAGTAGGAGTAGACTGGTAGAAAGGAAGGCATCTCACTGAAGTTTACTCAGTCATCAGTTAATGAAGCCATGGAAGAAC

>22739_22739_6_DIAPH1-BRIX1_DIAPH1_chr5_140963691_ENST00000398566_BRIX1_chr5_34924952_ENST00000336767_length(amino acids)=275AA_BP=143
MPGGSGVGAGSPASVNRDMEPPGGSLGPGRGTRDKKKGRSPDELPSAGGDGGKSKKFLERFTSMRIKKEKEKPNSAHRNSSASYGDDPTA
QSLQDVSDEQVLVLFEQMLLDMNLNEEKQQPLREKDIIIKREMVSQYLYTSKAIIEEDAALVEIGPRFVLNLIKIFQGSFGGPTLYENPH
YQSPNMHRRVIRSITAAKYREKQQVKDVQKLRKKEPKTLLPHDPTADVFVTPAEEKPIEIQWVKPEPKVDLKARKKRIYKRQRKMKQRMD

--------------------------------------------------------------
>22739_22739_7_DIAPH1-BRIX1_DIAPH1_chr5_140963691_ENST00000518047_BRIX1_chr5_34924952_ENST00000336767_length(transcript)=1275nt_BP=375nt
ATGGAGCCGCCCGGCGGGAGCCTGGGGCCCGGCCGCGGGACCCGGGACAAGAAGAAGGGCCGGAGCCCAGATGAGCTGCCCTCGGCGGGC
GGCGACGGCGGCAAATCTAAGAAATTTCTGGAGAGATTTACCAGCATGAGAATTAAGAAGGAGAAGGAAAAGCCCAATTCTGCTCATAGA
AATTCTTCTGCATCATATGGGGATGATCCCACAGCACAGTCATTGCAAGATGTTTCAGATGAACAAGTGCTGGTTCTCTTTGAACAGATG
CTGCTGGATATGAACCTGAATGAGGAGAAACAGCAACCTTTGAGGGAGAAGGACATCATCATCAAGAGGGAGATGGTGTCCCAATACTTG
TACACCTCCAAGGCTATCATAGAAGAAGATGCTGCTCTTGTAGAAATAGGACCTCGTTTTGTCTTAAATCTCATAAAGATTTTCCAGGGA
AGTTTTGGAGGACCAACTTTATATGAAAATCCTCACTACCAGTCACCAAACATGCATCGGCGTGTCATAAGATCCATCACAGCTGCAAAA
TACAGAGAGAAACAGCAAGTGAAAGATGTGCAAAAACTGAGAAAGAAAGAGCCGAAGACTCTTCTTCCACATGATCCCACTGCAGATGTT
TTTGTAACACCAGCTGAGGAGAAACCAATAGAAATACAGTGGGTAAAACCAGAGCCAAAAGTTGATTTGAAAGCAAGAAAGAAACGGATT
TACAAAAGGCAAAGAAAAATGAAACAGAGGATGGACAGTGGGAAAACAAAATAAGTCAATGGAAACCTGATTTGTTTTTCAGTTACTTTA
TATTTATTTTGTATTCAATGTGTAAATACTTTTATTATCTAATACTATCTTACGTCTAATTAGTGTAGCATTTACAAGAAAGAAAAATTA
AGATCTTAAAATCAGTGATTATCTTTTTCTAAATAAAATATCACCAGAATTCATCAGTTAATTTCTGATTTCTTTTTGAAGTTTGTGTTG
CTAAAAATGTAGCACACTTAATGTAGCCTGTTCTCTTGGGTTGGAATTTTTGGTTTAGCAAAGCTGAAATTCAGACATTTATTAGGTCAT
ATTATTTGTAAAAGCATTCAACACTTCAAGAGCATCGGTTGTGGATGGTAAAGTAGGAGTAGACTGGTAGAAAGGAAGGCATCTCACTGA
AGTTTACTCAGTCATCAGTTAATGAAGCCATGGAAGAACCAACCCCTGATCTGTCACTTCAAAAAAGAGTATATTAAAATGTTGAGGTTT

>22739_22739_7_DIAPH1-BRIX1_DIAPH1_chr5_140963691_ENST00000518047_BRIX1_chr5_34924952_ENST00000336767_length(amino acids)=257AA_BP=125
MEPPGGSLGPGRGTRDKKKGRSPDELPSAGGDGGKSKKFLERFTSMRIKKEKEKPNSAHRNSSASYGDDPTAQSLQDVSDEQVLVLFEQM
LLDMNLNEEKQQPLREKDIIIKREMVSQYLYTSKAIIEEDAALVEIGPRFVLNLIKIFQGSFGGPTLYENPHYQSPNMHRRVIRSITAAK

--------------------------------------------------------------
>22739_22739_8_DIAPH1-BRIX1_DIAPH1_chr5_140963691_ENST00000520569_BRIX1_chr5_34924952_ENST00000336767_length(transcript)=1158nt_BP=258nt
CTGGAGAGATTTACCAGCATGAGAATTAAGAAGGAGAAGGAAAAGCCCAATTCTGCTCATAGAAATTCTTCTGCATCATATGGGGATGAT
CCCACAGCACAGTCATTGCAAGATGTTTCAGATGAACAAGTGCTGGTTCTCTTTGAACAGATGCTGCTGGATATGAACCTGAATGAGGAG
AAACAGCAACCTTTGAGGGAGAAGGACATCATCATCAAGAGGGAGATGGTGTCCCAATACTTGTACACCTCCAAGGCTATCATAGAAGAA
GATGCTGCTCTTGTAGAAATAGGACCTCGTTTTGTCTTAAATCTCATAAAGATTTTCCAGGGAAGTTTTGGAGGACCAACTTTATATGAA
AATCCTCACTACCAGTCACCAAACATGCATCGGCGTGTCATAAGATCCATCACAGCTGCAAAATACAGAGAGAAACAGCAAGTGAAAGAT
GTGCAAAAACTGAGAAAGAAAGAGCCGAAGACTCTTCTTCCACATGATCCCACTGCAGATGTTTTTGTAACACCAGCTGAGGAGAAACCA
ATAGAAATACAGTGGGTAAAACCAGAGCCAAAAGTTGATTTGAAAGCAAGAAAGAAACGGATTTACAAAAGGCAAAGAAAAATGAAACAG
AGGATGGACAGTGGGAAAACAAAATAAGTCAATGGAAACCTGATTTGTTTTTCAGTTACTTTATATTTATTTTGTATTCAATGTGTAAAT
ACTTTTATTATCTAATACTATCTTACGTCTAATTAGTGTAGCATTTACAAGAAAGAAAAATTAAGATCTTAAAATCAGTGATTATCTTTT
TCTAAATAAAATATCACCAGAATTCATCAGTTAATTTCTGATTTCTTTTTGAAGTTTGTGTTGCTAAAAATGTAGCACACTTAATGTAGC
CTGTTCTCTTGGGTTGGAATTTTTGGTTTAGCAAAGCTGAAATTCAGACATTTATTAGGTCATATTATTTGTAAAAGCATTCAACACTTC
AAGAGCATCGGTTGTGGATGGTAAAGTAGGAGTAGACTGGTAGAAAGGAAGGCATCTCACTGAAGTTTACTCAGTCATCAGTTAATGAAG

>22739_22739_8_DIAPH1-BRIX1_DIAPH1_chr5_140963691_ENST00000520569_BRIX1_chr5_34924952_ENST00000336767_length(amino acids)=218AA_BP=86
LERFTSMRIKKEKEKPNSAHRNSSASYGDDPTAQSLQDVSDEQVLVLFEQMLLDMNLNEEKQQPLREKDIIIKREMVSQYLYTSKAIIEE
DAALVEIGPRFVLNLIKIFQGSFGGPTLYENPHYQSPNMHRRVIRSITAAKYREKQQVKDVQKLRKKEPKTLLPHDPTADVFVTPAEEKP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DIAPH1-BRIX1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for DIAPH1-BRIX1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for DIAPH1-BRIX1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source