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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:DICER1-GNL3 (FusionGDB2 ID:22789) |
Fusion Gene Summary for DICER1-GNL3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DICER1-GNL3 | Fusion gene ID: 22789 | Hgene | Tgene | Gene symbol | DICER1 | GNL3 | Gene ID | 23405 | 26354 |
| Gene name | dicer 1, ribonuclease III | G protein nucleolar 3 | |
| Synonyms | DCR1|Dicer|Dicer1e|GLOW|HERNA|K12H4.8-LIKE|MNG1|RMSE2 | C77032|E2IG3|NNP47|NS | |
| Cytomap | 14q32.13 | 3p21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | endoribonuclease DicerDicer1, Dcr-1 homologdicer 1, double-stranded RNA-specific endoribonucleasedicer 1, ribonuclease type IIIhelicase MOIhelicase with RNAse motif | guanine nucleotide-binding protein-like 3E2-induced gene 3 proteinestradiol-induced nucleotide binding proteinguanine nucleotide binding protein-like 3 (nucleolar)novel nucleolar protein 47nucleolar GTP-binding protein 3nucleostemin | |
| Modification date | 20200329 | 20200327 | |
| UniProtAcc | Q9UPY3 | Q9NVN8 | |
| Ensembl transtripts involved in fusion gene | ENST00000343455, ENST00000393063, ENST00000526495, ENST00000527414, ENST00000541352, ENST00000527416, ENST00000556045, | ENST00000460073, ENST00000394799, ENST00000418458, | |
| Fusion gene scores | * DoF score | 13 X 8 X 10=1040 | 4 X 8 X 4=128 |
| # samples | 15 | 6 | |
| ** MAII score | log2(15/1040*10)=-2.79354912253257 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/128*10)=-1.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DICER1 [Title/Abstract] AND GNL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DICER1(95590533)-GNL3(52726888), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | DICER1-GNL3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. DICER1-GNL3 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. DICER1-GNL3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DICER1 | GO:0030422 | production of siRNA involved in RNA interference | 15973356|17452327|23661684 |
| Hgene | DICER1 | GO:0031054 | pre-miRNA processing | 15973356|16357216|18178619|23661684|25549615 |
| Hgene | DICER1 | GO:0035087 | siRNA loading onto RISC involved in RNA interference | 15973356 |
| Hgene | DICER1 | GO:0035196 | production of miRNAs involved in gene silencing by miRNA | 15973356|23661684 |
| Hgene | DICER1 | GO:0035280 | miRNA loading onto RISC involved in gene silencing by miRNA | 18178619 |
| Hgene | DICER1 | GO:0038061 | NIK/NF-kappaB signaling | 26435691 |
| Hgene | DICER1 | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic | 21753850|25549615 |
| Tgene | GNL3 | GO:0017145 | stem cell division | 25522312 |
| Fusion gene breakpoints across DICER1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across GNL3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | GBM | TCGA-76-4928-01B | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + |
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Fusion Gene ORF analysis for DICER1-GNL3 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000343455 | ENST00000460073 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + |
| 5CDS-intron | ENST00000393063 | ENST00000460073 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + |
| 5CDS-intron | ENST00000526495 | ENST00000460073 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + |
| 5CDS-intron | ENST00000527414 | ENST00000460073 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + |
| 5CDS-intron | ENST00000541352 | ENST00000460073 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + |
| Frame-shift | ENST00000343455 | ENST00000394799 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + |
| Frame-shift | ENST00000343455 | ENST00000418458 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + |
| Frame-shift | ENST00000393063 | ENST00000394799 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + |
| Frame-shift | ENST00000393063 | ENST00000418458 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + |
| Frame-shift | ENST00000526495 | ENST00000394799 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + |
| Frame-shift | ENST00000526495 | ENST00000418458 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + |
| Frame-shift | ENST00000527414 | ENST00000394799 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + |
| Frame-shift | ENST00000527414 | ENST00000418458 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + |
| In-frame | ENST00000541352 | ENST00000394799 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + |
| In-frame | ENST00000541352 | ENST00000418458 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + |
| intron-3CDS | ENST00000527416 | ENST00000394799 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + |
| intron-3CDS | ENST00000527416 | ENST00000418458 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + |
| intron-3CDS | ENST00000556045 | ENST00000394799 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + |
| intron-3CDS | ENST00000556045 | ENST00000418458 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + |
| intron-intron | ENST00000527416 | ENST00000460073 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + |
| intron-intron | ENST00000556045 | ENST00000460073 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000541352 | DICER1 | chr14 | 95590533 | - | ENST00000418458 | GNL3 | chr3 | 52726888 | + | 2383 | 1385 | 9 | 2165 | 718 |
| ENST00000541352 | DICER1 | chr14 | 95590533 | - | ENST00000394799 | GNL3 | chr3 | 52726888 | + | 2383 | 1385 | 9 | 2165 | 718 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000541352 | ENST00000418458 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + | 0.001312498 | 0.99868757 |
| ENST00000541352 | ENST00000394799 | DICER1 | chr14 | 95590533 | - | GNL3 | chr3 | 52726888 | + | 0.001312498 | 0.99868757 |
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Fusion Genomic Features for DICER1-GNL3 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| DICER1 | chr14 | 95590532 | - | GNL3 | chr3 | 52726887 | + | 0.000312735 | 0.9996873 |
| DICER1 | chr14 | 95590532 | - | GNL3 | chr3 | 52726887 | + | 0.000312735 | 0.9996873 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for DICER1-GNL3 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:95590533/chr3:52726888) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DICER1 | GNL3 |
| FUNCTION: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. {ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619}. | FUNCTION: Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. {ECO:0000269|PubMed:16251348, ECO:0000269|PubMed:17034816, ECO:0000269|PubMed:19487455, ECO:0000269|PubMed:21132010}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000343455 | - | 8 | 27 | 51_227 | 458 | 1923.0 | Domain | Helicase ATP-binding |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000393063 | - | 9 | 28 | 51_227 | 458 | 1923.0 | Domain | Helicase ATP-binding |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000526495 | - | 10 | 29 | 51_227 | 458 | 1923.0 | Domain | Helicase ATP-binding |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000527414 | - | 8 | 27 | 51_227 | 458 | 1923.0 | Domain | Helicase ATP-binding |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000541352 | - | 7 | 25 | 51_227 | 458 | 1830.0 | Domain | Helicase ATP-binding |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000343455 | - | 8 | 27 | 175_178 | 458 | 1923.0 | Motif | Note=DECH box |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000393063 | - | 9 | 28 | 175_178 | 458 | 1923.0 | Motif | Note=DECH box |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000526495 | - | 10 | 29 | 175_178 | 458 | 1923.0 | Motif | Note=DECH box |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000527414 | - | 8 | 27 | 175_178 | 458 | 1923.0 | Motif | Note=DECH box |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000541352 | - | 7 | 25 | 175_178 | 458 | 1830.0 | Motif | Note=DECH box |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000343455 | - | 8 | 27 | 64_71 | 458 | 1923.0 | Nucleotide binding | ATP |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000393063 | - | 9 | 28 | 64_71 | 458 | 1923.0 | Nucleotide binding | ATP |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000526495 | - | 10 | 29 | 64_71 | 458 | 1923.0 | Nucleotide binding | ATP |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000527414 | - | 8 | 27 | 64_71 | 458 | 1923.0 | Nucleotide binding | ATP |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000541352 | - | 7 | 25 | 64_71 | 458 | 1830.0 | Nucleotide binding | ATP |
| Tgene | GNL3 | chr14:95590533 | chr3:52726888 | ENST00000394799 | 8 | 15 | 305_308 | 277 | 538.0 | Nucleotide binding | GTP | |
| Tgene | GNL3 | chr14:95590533 | chr3:52726888 | ENST00000418458 | 8 | 15 | 305_308 | 289 | 550.0 | Nucleotide binding | GTP | |
| Tgene | GNL3 | chr14:95590533 | chr3:52726888 | ENST00000394799 | 8 | 15 | 282_456 | 277 | 538.0 | Region | Intermediate | |
| Tgene | GNL3 | chr14:95590533 | chr3:52726888 | ENST00000394799 | 8 | 15 | 465_543 | 277 | 538.0 | Region | Acidic | |
| Tgene | GNL3 | chr14:95590533 | chr3:52726888 | ENST00000418458 | 8 | 15 | 465_543 | 289 | 550.0 | Region | Acidic |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000343455 | - | 8 | 27 | 1276_1403 | 458 | 1923.0 | Domain | RNase III 1 |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000343455 | - | 8 | 27 | 1666_1824 | 458 | 1923.0 | Domain | RNase III 2 |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000343455 | - | 8 | 27 | 1849_1914 | 458 | 1923.0 | Domain | DRBM |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000343455 | - | 8 | 27 | 433_602 | 458 | 1923.0 | Domain | Helicase C-terminal |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000343455 | - | 8 | 27 | 630_722 | 458 | 1923.0 | Domain | Dicer dsRNA-binding fold |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000343455 | - | 8 | 27 | 891_1042 | 458 | 1923.0 | Domain | PAZ |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000393063 | - | 9 | 28 | 1276_1403 | 458 | 1923.0 | Domain | RNase III 1 |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000393063 | - | 9 | 28 | 1666_1824 | 458 | 1923.0 | Domain | RNase III 2 |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000393063 | - | 9 | 28 | 1849_1914 | 458 | 1923.0 | Domain | DRBM |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000393063 | - | 9 | 28 | 433_602 | 458 | 1923.0 | Domain | Helicase C-terminal |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000393063 | - | 9 | 28 | 630_722 | 458 | 1923.0 | Domain | Dicer dsRNA-binding fold |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000393063 | - | 9 | 28 | 891_1042 | 458 | 1923.0 | Domain | PAZ |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000526495 | - | 10 | 29 | 1276_1403 | 458 | 1923.0 | Domain | RNase III 1 |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000526495 | - | 10 | 29 | 1666_1824 | 458 | 1923.0 | Domain | RNase III 2 |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000526495 | - | 10 | 29 | 1849_1914 | 458 | 1923.0 | Domain | DRBM |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000526495 | - | 10 | 29 | 433_602 | 458 | 1923.0 | Domain | Helicase C-terminal |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000526495 | - | 10 | 29 | 630_722 | 458 | 1923.0 | Domain | Dicer dsRNA-binding fold |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000526495 | - | 10 | 29 | 891_1042 | 458 | 1923.0 | Domain | PAZ |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000527414 | - | 8 | 27 | 1276_1403 | 458 | 1923.0 | Domain | RNase III 1 |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000527414 | - | 8 | 27 | 1666_1824 | 458 | 1923.0 | Domain | RNase III 2 |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000527414 | - | 8 | 27 | 1849_1914 | 458 | 1923.0 | Domain | DRBM |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000527414 | - | 8 | 27 | 433_602 | 458 | 1923.0 | Domain | Helicase C-terminal |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000527414 | - | 8 | 27 | 630_722 | 458 | 1923.0 | Domain | Dicer dsRNA-binding fold |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000527414 | - | 8 | 27 | 891_1042 | 458 | 1923.0 | Domain | PAZ |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000541352 | - | 7 | 25 | 1276_1403 | 458 | 1830.0 | Domain | RNase III 1 |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000541352 | - | 7 | 25 | 1666_1824 | 458 | 1830.0 | Domain | RNase III 2 |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000541352 | - | 7 | 25 | 1849_1914 | 458 | 1830.0 | Domain | DRBM |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000541352 | - | 7 | 25 | 433_602 | 458 | 1830.0 | Domain | Helicase C-terminal |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000541352 | - | 7 | 25 | 630_722 | 458 | 1830.0 | Domain | Dicer dsRNA-binding fold |
| Hgene | DICER1 | chr14:95590533 | chr3:52726888 | ENST00000541352 | - | 7 | 25 | 891_1042 | 458 | 1830.0 | Domain | PAZ |
| Tgene | GNL3 | chr14:95590533 | chr3:52726888 | ENST00000394799 | 8 | 15 | 56_95 | 277 | 538.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | GNL3 | chr14:95590533 | chr3:52726888 | ENST00000418458 | 8 | 15 | 56_95 | 289 | 550.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | GNL3 | chr14:95590533 | chr3:52726888 | ENST00000394799 | 8 | 15 | 131_312 | 277 | 538.0 | Domain | CP-type G | |
| Tgene | GNL3 | chr14:95590533 | chr3:52726888 | ENST00000418458 | 8 | 15 | 131_312 | 289 | 550.0 | Domain | CP-type G | |
| Tgene | GNL3 | chr14:95590533 | chr3:52726888 | ENST00000394799 | 8 | 15 | 178_181 | 277 | 538.0 | Nucleotide binding | GTP | |
| Tgene | GNL3 | chr14:95590533 | chr3:52726888 | ENST00000394799 | 8 | 15 | 261_268 | 277 | 538.0 | Nucleotide binding | GTP | |
| Tgene | GNL3 | chr14:95590533 | chr3:52726888 | ENST00000418458 | 8 | 15 | 178_181 | 289 | 550.0 | Nucleotide binding | GTP | |
| Tgene | GNL3 | chr14:95590533 | chr3:52726888 | ENST00000418458 | 8 | 15 | 261_268 | 289 | 550.0 | Nucleotide binding | GTP | |
| Tgene | GNL3 | chr14:95590533 | chr3:52726888 | ENST00000394799 | 8 | 15 | 2_46 | 277 | 538.0 | Region | Basic | |
| Tgene | GNL3 | chr14:95590533 | chr3:52726888 | ENST00000418458 | 8 | 15 | 282_456 | 289 | 550.0 | Region | Intermediate | |
| Tgene | GNL3 | chr14:95590533 | chr3:52726888 | ENST00000418458 | 8 | 15 | 2_46 | 289 | 550.0 | Region | Basic |
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Fusion Gene Sequence for DICER1-GNL3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >22789_22789_1_DICER1-GNL3_DICER1_chr14_95590533_ENST00000541352_GNL3_chr3_52726888_ENST00000394799_length(transcript)=2383nt_BP=1385nt ACTGGATGAATGAAAAGCCCTGCTTTGCAACCCCTCAGCATGGCAGGCCTGCAGCTCATGACCCCTGCTTCCTCACCAATGGGTCCTTTC TTTGGACTGCCATGGCAACAAGAAGCAATTCATGATAACATTTATACGCCAAGAAAATATCAGGTTGAACTGCTTGAAGCAGCTCTGGAT CATAATACCATCGTCTGTTTAAACACTGGCTCAGGGAAGACATTTATTGCAGTACTACTCACTAAAGAGCTGTCCTATCAGATCAGGGGA GACTTCAGCAGAAATGGAAAAAGGACGGTGTTCTTGGTCAACTCTGCAAACCAGGTTGCTCAACAAGTGTCAGCTGTCAGAACTCATTCA GATCTCAAGGTTGGGGAATACTCAAACCTAGAAGTAAATGCATCTTGGACAAAAGAGAGATGGAACCAAGAGTTTACTAAGCACCAGGTT CTCATTATGACTTGCTATGTCGCCTTGAATGTTTTGAAAAATGGTTACTTATCACTGTCAGACATTAACCTTTTGGTGTTTGATGAGTGT CATCTTGCAATCCTAGACCACCCCTATCGAGAAATTATGAAGCTCTGTGAAAATTGTCCATCATGTCCTCGCATTTTGGGACTAACTGCT TCCATTTTAAATGGGAAATGTGATCCAGAGGAATTGGAAGAAAAGATTCAGAAACTAGAGAAAATTCTTAAGAGTAATGCTGAAACTGCA ACTGACCTGGTGGTCTTAGACAGGTATACTTCTCAGCCATGTGAGATTGTGGTGGATTGTGGACCATTTACTGACAGAAGTGGGCTTTAT GAAAGACTGCTGATGGAATTAGAAGAAGCACTTAATTTTATCAATGATTGTAATATATCTGTACATTCAAAAGAAAGAGATTCTACTTTA ATTTCGAAACAGATACTATCAGACTGTCGTGCCGTATTGGTAGTTCTGGGACCCTGGTGTGCAGATAAAGTAGCTGGAATGATGGTAAGA GAACTACAGAAATACATCAAACATGAGCAAGAGGAGCTGCACAGGAAATTTTTATTGTTTACAGACACTTTCCTAAGGAAAATACATGCA CTATGTGAAGAGCACTTCTCACCTGCCTCACTTGACCTGAAATTTGTAACTCCTAAAGTAATCAAACTGCTCGAAATCTTACGCAAATAT AAACCATATGAGCGACAGCAGTTTGAAAGCGTTGAGTGGTATAATAATAGAAATCAGGATAATTATGTGTCATGGAGTGATTCTGAGGAT GATGATGAGGATGAAGAAATTGAAGAAAAAGAGAAGCCAGAGACAAATTTTCCTTCTCCTTTTACCAACATTTTGTGCGGAATTATTTTT GTGGAAAGAAGATACACAGCAGTTGTCTTAAACAGGAGCATGCAAGTTGTCCCCTTGGACAAACAGATCACAATCATAGATAGTCCGAGC TTCATCGTATCTCCACTTAATTCCTCCTCTGCGCTTGCTCTGCGAAGTCCAGCAAGTATTGAAGTAGTAAAACCGATGGAGGCTGCCAGT GCCATCCTTTCCCAGGCTGATGCTCGACAGGTAGTACTGAAATATACTGTCCCAGGCTACAGGAATTCTCTGGAATTTTTTACTGTGCTT GCTCAGAGAAGAGGTATGCACCAAAAAGGTGGAATCCCAAATGTTGAAGGTGCTGCCAAACTGCTGTGGTCTGAGTGGACAGGTGCCTCA TTAGCTTACTATTGCCATCCCCCTACATCTTGGACTCCTCCTCCATATTTTAATGAGAGTATTGTGGTAGACATGAAAAGCGGCTTCAAT CTGGAAGAACTGGAAAAGAACAATGCACAGAGCATAAGAGCCATCAAGGGCCCTCATTTGGCCAATAGCATCCTTTTCCAGTCTTCCGGT CTGACAAATGGAATAATAGAAGAAAAGGACATACATGAAGAATTGCCAAAACGGAAAGAAAGGAAGCAGGAGGAGAGGGAGGATGACAAA GACAGTGACCAGGAAACTGTTGATGAAGAAGTTGATGAAAACAGCTCAGGCATGTTTGCTGCAGAAGAGACAGGGGAGGCACTGTCTGAG GAGACTACAGCAGGTGAACAGTCTACAAGGTCTTTTATCTTGGATAAAATCATTGAAGAGGATGATGCTTATGACTTCAGTACAGATTAT GTGTAACAGAACAATGGCTTTTTATGATTTTTTTTTTAACATTTTAAGCAGACTGCTAAACTGTTCTCTGTATAAGTTATGGTATGCATG AGCTGTGTAAATTTTGTGAATATGTATTATATTAAAACCAGGCAACTTGGAATCCCTAAATTCTGTAAAAAGACAATTCATCTCATTGTG >22789_22789_1_DICER1-GNL3_DICER1_chr14_95590533_ENST00000541352_GNL3_chr3_52726888_ENST00000394799_length(amino acids)=718AA_BP=458 MKSPALQPLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFS RNGKRTVFLVNSANQVAQQVSAVRTHSDLKVGEYSNLEVNASWTKERWNQEFTKHQVLIMTCYVALNVLKNGYLSLSDINLLVFDECHLA ILDHPYREIMKLCENCPSCPRILGLTASILNGKCDPEELEEKIQKLEKILKSNAETATDLVVLDRYTSQPCEIVVDCGPFTDRSGLYERL LMELEEALNFINDCNISVHSKERDSTLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTFLRKIHALCE EHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDEDEEIEEKEKPETNFPSPFTNILCGIIFVER RYTAVVLNRSMQVVPLDKQITIIDSPSFIVSPLNSSSALALRSPASIEVVKPMEAASAILSQADARQVVLKYTVPGYRNSLEFFTVLAQR RGMHQKGGIPNVEGAAKLLWSEWTGASLAYYCHPPTSWTPPPYFNESIVVDMKSGFNLEELEKNNAQSIRAIKGPHLANSILFQSSGLTN -------------------------------------------------------------- >22789_22789_2_DICER1-GNL3_DICER1_chr14_95590533_ENST00000541352_GNL3_chr3_52726888_ENST00000418458_length(transcript)=2383nt_BP=1385nt ACTGGATGAATGAAAAGCCCTGCTTTGCAACCCCTCAGCATGGCAGGCCTGCAGCTCATGACCCCTGCTTCCTCACCAATGGGTCCTTTC TTTGGACTGCCATGGCAACAAGAAGCAATTCATGATAACATTTATACGCCAAGAAAATATCAGGTTGAACTGCTTGAAGCAGCTCTGGAT CATAATACCATCGTCTGTTTAAACACTGGCTCAGGGAAGACATTTATTGCAGTACTACTCACTAAAGAGCTGTCCTATCAGATCAGGGGA GACTTCAGCAGAAATGGAAAAAGGACGGTGTTCTTGGTCAACTCTGCAAACCAGGTTGCTCAACAAGTGTCAGCTGTCAGAACTCATTCA GATCTCAAGGTTGGGGAATACTCAAACCTAGAAGTAAATGCATCTTGGACAAAAGAGAGATGGAACCAAGAGTTTACTAAGCACCAGGTT CTCATTATGACTTGCTATGTCGCCTTGAATGTTTTGAAAAATGGTTACTTATCACTGTCAGACATTAACCTTTTGGTGTTTGATGAGTGT CATCTTGCAATCCTAGACCACCCCTATCGAGAAATTATGAAGCTCTGTGAAAATTGTCCATCATGTCCTCGCATTTTGGGACTAACTGCT TCCATTTTAAATGGGAAATGTGATCCAGAGGAATTGGAAGAAAAGATTCAGAAACTAGAGAAAATTCTTAAGAGTAATGCTGAAACTGCA ACTGACCTGGTGGTCTTAGACAGGTATACTTCTCAGCCATGTGAGATTGTGGTGGATTGTGGACCATTTACTGACAGAAGTGGGCTTTAT GAAAGACTGCTGATGGAATTAGAAGAAGCACTTAATTTTATCAATGATTGTAATATATCTGTACATTCAAAAGAAAGAGATTCTACTTTA ATTTCGAAACAGATACTATCAGACTGTCGTGCCGTATTGGTAGTTCTGGGACCCTGGTGTGCAGATAAAGTAGCTGGAATGATGGTAAGA GAACTACAGAAATACATCAAACATGAGCAAGAGGAGCTGCACAGGAAATTTTTATTGTTTACAGACACTTTCCTAAGGAAAATACATGCA CTATGTGAAGAGCACTTCTCACCTGCCTCACTTGACCTGAAATTTGTAACTCCTAAAGTAATCAAACTGCTCGAAATCTTACGCAAATAT AAACCATATGAGCGACAGCAGTTTGAAAGCGTTGAGTGGTATAATAATAGAAATCAGGATAATTATGTGTCATGGAGTGATTCTGAGGAT GATGATGAGGATGAAGAAATTGAAGAAAAAGAGAAGCCAGAGACAAATTTTCCTTCTCCTTTTACCAACATTTTGTGCGGAATTATTTTT GTGGAAAGAAGATACACAGCAGTTGTCTTAAACAGGAGCATGCAAGTTGTCCCCTTGGACAAACAGATCACAATCATAGATAGTCCGAGC TTCATCGTATCTCCACTTAATTCCTCCTCTGCGCTTGCTCTGCGAAGTCCAGCAAGTATTGAAGTAGTAAAACCGATGGAGGCTGCCAGT GCCATCCTTTCCCAGGCTGATGCTCGACAGGTAGTACTGAAATATACTGTCCCAGGCTACAGGAATTCTCTGGAATTTTTTACTGTGCTT GCTCAGAGAAGAGGTATGCACCAAAAAGGTGGAATCCCAAATGTTGAAGGTGCTGCCAAACTGCTGTGGTCTGAGTGGACAGGTGCCTCA TTAGCTTACTATTGCCATCCCCCTACATCTTGGACTCCTCCTCCATATTTTAATGAGAGTATTGTGGTAGACATGAAAAGCGGCTTCAAT CTGGAAGAACTGGAAAAGAACAATGCACAGAGCATAAGAGCCATCAAGGGCCCTCATTTGGCCAATAGCATCCTTTTCCAGTCTTCCGGT CTGACAAATGGAATAATAGAAGAAAAGGACATACATGAAGAATTGCCAAAACGGAAAGAAAGGAAGCAGGAGGAGAGGGAGGATGACAAA GACAGTGACCAGGAAACTGTTGATGAAGAAGTTGATGAAAACAGCTCAGGCATGTTTGCTGCAGAAGAGACAGGGGAGGCACTGTCTGAG GAGACTACAGCAGGTGAACAGTCTACAAGGTCTTTTATCTTGGATAAAATCATTGAAGAGGATGATGCTTATGACTTCAGTACAGATTAT GTGTAACAGAACAATGGCTTTTTATGATTTTTTTTTTAACATTTTAAGCAGACTGCTAAACTGTTCTCTGTATAAGTTATGGTATGCATG AGCTGTGTAAATTTTGTGAATATGTATTATATTAAAACCAGGCAACTTGGAATCCCTAAATTCTGTAAAAAGACAATTCATCTCATTGTG >22789_22789_2_DICER1-GNL3_DICER1_chr14_95590533_ENST00000541352_GNL3_chr3_52726888_ENST00000418458_length(amino acids)=718AA_BP=458 MKSPALQPLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFS RNGKRTVFLVNSANQVAQQVSAVRTHSDLKVGEYSNLEVNASWTKERWNQEFTKHQVLIMTCYVALNVLKNGYLSLSDINLLVFDECHLA ILDHPYREIMKLCENCPSCPRILGLTASILNGKCDPEELEEKIQKLEKILKSNAETATDLVVLDRYTSQPCEIVVDCGPFTDRSGLYERL LMELEEALNFINDCNISVHSKERDSTLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTFLRKIHALCE EHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDEDEEIEEKEKPETNFPSPFTNILCGIIFVER RYTAVVLNRSMQVVPLDKQITIIDSPSFIVSPLNSSSALALRSPASIEVVKPMEAASAILSQADARQVVLKYTVPGYRNSLEFFTVLAQR RGMHQKGGIPNVEGAAKLLWSEWTGASLAYYCHPPTSWTPPPYFNESIVVDMKSGFNLEELEKNNAQSIRAIKGPHLANSILFQSSGLTN -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for DICER1-GNL3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DICER1-GNL3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DICER1-GNL3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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