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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DICER1-PAPOLA (FusionGDB2 ID:22793)

Fusion Gene Summary for DICER1-PAPOLA

check button Fusion gene summary
Fusion gene informationFusion gene name: DICER1-PAPOLA
Fusion gene ID: 22793
HgeneTgene
Gene symbol

DICER1

PAPOLA

Gene ID

23405

10914

Gene namedicer 1, ribonuclease IIIpoly(A) polymerase alpha
SynonymsDCR1|Dicer|Dicer1e|GLOW|HERNA|K12H4.8-LIKE|MNG1|RMSE2PAP|PAP-alpha
Cytomap

14q32.13

14q32.2

Type of geneprotein-codingprotein-coding
Descriptionendoribonuclease DicerDicer1, Dcr-1 homologdicer 1, double-stranded RNA-specific endoribonucleasedicer 1, ribonuclease type IIIhelicase MOIhelicase with RNAse motifpoly(A) polymerase alphapolynucleotide adenylyltransferase alpha
Modification date2020032920200313
UniProtAcc

Q9UPY3

.
Ensembl transtripts involved in fusion geneENST00000343455, ENST00000393063, 
ENST00000526495, ENST00000527414, 
ENST00000541352, ENST00000556045, 
ENST00000527416, 		ENST00000392990, 
ENST00000554130, ENST00000557320, 
ENST00000557471, ENST00000216277, 
Fusion gene scores* DoF score13 X 8 X 10=10407 X 10 X 6=420
# samples 158
** MAII scorelog2(15/1040*10)=-2.79354912253257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/420*10)=-2.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DICER1 [Title/Abstract] AND PAPOLA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDICER1(95569683)-PAPOLA(97008580), # samples:1
Anticipated loss of major functional domain due to fusion event.DICER1-PAPOLA seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
DICER1-PAPOLA seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
DICER1-PAPOLA seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDICER1

GO:0030422

production of siRNA involved in RNA interference

15973356|17452327|23661684

HgeneDICER1

GO:0031054

pre-miRNA processing

15973356|16357216|18178619|23661684|25549615

HgeneDICER1

GO:0035087

siRNA loading onto RISC involved in RNA interference

15973356

HgeneDICER1

GO:0035196

production of miRNAs involved in gene silencing by miRNA

15973356|23661684

HgeneDICER1

GO:0035280

miRNA loading onto RISC involved in gene silencing by miRNA

18178619

HgeneDICER1

GO:0038061

NIK/NF-kappaB signaling

26435691

HgeneDICER1

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

21753850|25549615

TgenePAPOLA

GO:0006378

mRNA polyadenylation

7590244|19224921

TgenePAPOLA

GO:0031440

regulation of mRNA 3'-end processing

19224921


check buttonFusion gene breakpoints across DICER1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PAPOLA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-77-8148-01ADICER1chr14

95569683

-PAPOLAchr14

97008580

+


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Fusion Gene ORF analysis for DICER1-PAPOLA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000343455ENST00000392990DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000343455ENST00000554130DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000343455ENST00000557320DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000343455ENST00000557471DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000393063ENST00000392990DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000393063ENST00000554130DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000393063ENST00000557320DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000393063ENST00000557471DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000526495ENST00000392990DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000526495ENST00000554130DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000526495ENST00000557320DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000526495ENST00000557471DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000527414ENST00000392990DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000527414ENST00000554130DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000527414ENST00000557320DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000527414ENST00000557471DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000541352ENST00000392990DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000541352ENST00000554130DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000541352ENST00000557320DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000541352ENST00000557471DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000556045ENST00000392990DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000556045ENST00000554130DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000556045ENST00000557320DICER1chr14

95569683

-PAPOLAchr14

97008580

+
5CDS-intronENST00000556045ENST00000557471DICER1chr14

95569683

-PAPOLAchr14

97008580

+
Frame-shiftENST00000343455ENST00000216277DICER1chr14

95569683

-PAPOLAchr14

97008580

+
Frame-shiftENST00000393063ENST00000216277DICER1chr14

95569683

-PAPOLAchr14

97008580

+
Frame-shiftENST00000526495ENST00000216277DICER1chr14

95569683

-PAPOLAchr14

97008580

+
Frame-shiftENST00000527414ENST00000216277DICER1chr14

95569683

-PAPOLAchr14

97008580

+
Frame-shiftENST00000541352ENST00000216277DICER1chr14

95569683

-PAPOLAchr14

97008580

+
In-frameENST00000556045ENST00000216277DICER1chr14

95569683

-PAPOLAchr14

97008580

+
intron-3CDSENST00000527416ENST00000216277DICER1chr14

95569683

-PAPOLAchr14

97008580

+
intron-intronENST00000527416ENST00000392990DICER1chr14

95569683

-PAPOLAchr14

97008580

+
intron-intronENST00000527416ENST00000554130DICER1chr14

95569683

-PAPOLAchr14

97008580

+
intron-intronENST00000527416ENST00000557320DICER1chr14

95569683

-PAPOLAchr14

97008580

+
intron-intronENST00000527416ENST00000557471DICER1chr14

95569683

-PAPOLAchr14

97008580

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000556045DICER1chr1495569683-ENST00000216277PAPOLAchr1497008580+4211102710732149358

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000556045ENST00000216277DICER1chr1495569683-PAPOLAchr1497008580+0.001005830.9989942

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Fusion Genomic Features for DICER1-PAPOLA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DICER1chr1495569682-PAPOLAchr1497008579+0.0140426970.9859574
DICER1chr1495569682-PAPOLAchr1497008579+0.0140426970.9859574

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DICER1-PAPOLA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:95569683/chr14:97008580)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DICER1

Q9UPY3

.
FUNCTION: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. {ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDICER1chr14:95569683chr14:97008580ENST00000343455-2127433_60213501923.0DomainHelicase C-terminal
HgeneDICER1chr14:95569683chr14:97008580ENST00000343455-212751_22713501923.0DomainHelicase ATP-binding
HgeneDICER1chr14:95569683chr14:97008580ENST00000343455-2127630_72213501923.0DomainDicer dsRNA-binding fold
HgeneDICER1chr14:95569683chr14:97008580ENST00000343455-2127891_104213501923.0DomainPAZ
HgeneDICER1chr14:95569683chr14:97008580ENST00000393063-2228433_60213501923.0DomainHelicase C-terminal
HgeneDICER1chr14:95569683chr14:97008580ENST00000393063-222851_22713501923.0DomainHelicase ATP-binding
HgeneDICER1chr14:95569683chr14:97008580ENST00000393063-2228630_72213501923.0DomainDicer dsRNA-binding fold
HgeneDICER1chr14:95569683chr14:97008580ENST00000393063-2228891_104213501923.0DomainPAZ
HgeneDICER1chr14:95569683chr14:97008580ENST00000526495-2329433_60213501923.0DomainHelicase C-terminal
HgeneDICER1chr14:95569683chr14:97008580ENST00000526495-232951_22713501923.0DomainHelicase ATP-binding
HgeneDICER1chr14:95569683chr14:97008580ENST00000526495-2329630_72213501923.0DomainDicer dsRNA-binding fold
HgeneDICER1chr14:95569683chr14:97008580ENST00000526495-2329891_104213501923.0DomainPAZ
HgeneDICER1chr14:95569683chr14:97008580ENST00000527414-2127433_60213501923.0DomainHelicase C-terminal
HgeneDICER1chr14:95569683chr14:97008580ENST00000527414-212751_22713501923.0DomainHelicase ATP-binding
HgeneDICER1chr14:95569683chr14:97008580ENST00000527414-2127630_72213501923.0DomainDicer dsRNA-binding fold
HgeneDICER1chr14:95569683chr14:97008580ENST00000527414-2127891_104213501923.0DomainPAZ
HgeneDICER1chr14:95569683chr14:97008580ENST00000541352-2025433_60213501830.0DomainHelicase C-terminal
HgeneDICER1chr14:95569683chr14:97008580ENST00000541352-202551_22713501830.0DomainHelicase ATP-binding
HgeneDICER1chr14:95569683chr14:97008580ENST00000541352-2025630_72213501830.0DomainDicer dsRNA-binding fold
HgeneDICER1chr14:95569683chr14:97008580ENST00000541352-2025891_104213501830.0DomainPAZ
HgeneDICER1chr14:95569683chr14:97008580ENST00000343455-2127175_17813501923.0MotifNote=DECH box
HgeneDICER1chr14:95569683chr14:97008580ENST00000393063-2228175_17813501923.0MotifNote=DECH box
HgeneDICER1chr14:95569683chr14:97008580ENST00000526495-2329175_17813501923.0MotifNote=DECH box
HgeneDICER1chr14:95569683chr14:97008580ENST00000527414-2127175_17813501923.0MotifNote=DECH box
HgeneDICER1chr14:95569683chr14:97008580ENST00000541352-2025175_17813501830.0MotifNote=DECH box
HgeneDICER1chr14:95569683chr14:97008580ENST00000343455-212764_7113501923.0Nucleotide bindingATP
HgeneDICER1chr14:95569683chr14:97008580ENST00000393063-222864_7113501923.0Nucleotide bindingATP
HgeneDICER1chr14:95569683chr14:97008580ENST00000526495-232964_7113501923.0Nucleotide bindingATP
HgeneDICER1chr14:95569683chr14:97008580ENST00000527414-212764_7113501923.0Nucleotide bindingATP
HgeneDICER1chr14:95569683chr14:97008580ENST00000541352-202564_7113501830.0Nucleotide bindingATP
TgenePAPOLAchr14:95569683chr14:97008580ENST000002162771122504_507371746.0Compositional biasNote=Poly-Lys
TgenePAPOLAchr14:95569683chr14:97008580ENST0000055732009504_5070286.0Compositional biasNote=Poly-Lys
TgenePAPOLAchr14:95569683chr14:97008580ENST000005573200953_570286.0Compositional biasNote=Poly-Glu
TgenePAPOLAchr14:95569683chr14:97008580ENST0000055747107504_5070239.0Compositional biasNote=Poly-Lys
TgenePAPOLAchr14:95569683chr14:97008580ENST000005574710753_570239.0Compositional biasNote=Poly-Glu
TgenePAPOLAchr14:95569683chr14:97008580ENST000002162771122490_507371746.0MotifNuclear localization signal 1
TgenePAPOLAchr14:95569683chr14:97008580ENST000002162771122650_665371746.0MotifNuclear localization signal 2
TgenePAPOLAchr14:95569683chr14:97008580ENST0000055732009490_5070286.0MotifNuclear localization signal 1
TgenePAPOLAchr14:95569683chr14:97008580ENST0000055732009650_6650286.0MotifNuclear localization signal 2
TgenePAPOLAchr14:95569683chr14:97008580ENST0000055747107490_5070239.0MotifNuclear localization signal 1
TgenePAPOLAchr14:95569683chr14:97008580ENST0000055747107650_6650239.0MotifNuclear localization signal 2
TgenePAPOLAchr14:95569683chr14:97008580ENST0000055732009100_1020286.0Nucleotide bindingATP
TgenePAPOLAchr14:95569683chr14:97008580ENST0000055732009113_1150286.0Nucleotide bindingATP
TgenePAPOLAchr14:95569683chr14:97008580ENST0000055732009246_2470286.0Nucleotide bindingATP
TgenePAPOLAchr14:95569683chr14:97008580ENST0000055747107100_1020239.0Nucleotide bindingATP
TgenePAPOLAchr14:95569683chr14:97008580ENST0000055747107113_1150239.0Nucleotide bindingATP
TgenePAPOLAchr14:95569683chr14:97008580ENST0000055747107246_2470239.0Nucleotide bindingATP
TgenePAPOLAchr14:95569683chr14:97008580ENST000002162771122508_643371746.0RegionNote=Ser/Thr-rich
TgenePAPOLAchr14:95569683chr14:97008580ENST0000055732009508_6430286.0RegionNote=Ser/Thr-rich
TgenePAPOLAchr14:95569683chr14:97008580ENST0000055747107508_6430239.0RegionNote=Ser/Thr-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDICER1chr14:95569683chr14:97008580ENST00000343455-21271276_140313501923.0DomainRNase III 1
HgeneDICER1chr14:95569683chr14:97008580ENST00000343455-21271666_182413501923.0DomainRNase III 2
HgeneDICER1chr14:95569683chr14:97008580ENST00000343455-21271849_191413501923.0DomainDRBM
HgeneDICER1chr14:95569683chr14:97008580ENST00000393063-22281276_140313501923.0DomainRNase III 1
HgeneDICER1chr14:95569683chr14:97008580ENST00000393063-22281666_182413501923.0DomainRNase III 2
HgeneDICER1chr14:95569683chr14:97008580ENST00000393063-22281849_191413501923.0DomainDRBM
HgeneDICER1chr14:95569683chr14:97008580ENST00000526495-23291276_140313501923.0DomainRNase III 1
HgeneDICER1chr14:95569683chr14:97008580ENST00000526495-23291666_182413501923.0DomainRNase III 2
HgeneDICER1chr14:95569683chr14:97008580ENST00000526495-23291849_191413501923.0DomainDRBM
HgeneDICER1chr14:95569683chr14:97008580ENST00000527414-21271276_140313501923.0DomainRNase III 1
HgeneDICER1chr14:95569683chr14:97008580ENST00000527414-21271666_182413501923.0DomainRNase III 2
HgeneDICER1chr14:95569683chr14:97008580ENST00000527414-21271849_191413501923.0DomainDRBM
HgeneDICER1chr14:95569683chr14:97008580ENST00000541352-20251276_140313501830.0DomainRNase III 1
HgeneDICER1chr14:95569683chr14:97008580ENST00000541352-20251666_182413501830.0DomainRNase III 2
HgeneDICER1chr14:95569683chr14:97008580ENST00000541352-20251849_191413501830.0DomainDRBM
TgenePAPOLAchr14:95569683chr14:97008580ENST00000216277112253_57371746.0Compositional biasNote=Poly-Glu
TgenePAPOLAchr14:95569683chr14:97008580ENST000002162771122100_102371746.0Nucleotide bindingATP
TgenePAPOLAchr14:95569683chr14:97008580ENST000002162771122113_115371746.0Nucleotide bindingATP
TgenePAPOLAchr14:95569683chr14:97008580ENST000002162771122246_247371746.0Nucleotide bindingATP


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Fusion Gene Sequence for DICER1-PAPOLA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22793_22793_1_DICER1-PAPOLA_DICER1_chr14_95569683_ENST00000556045_PAPOLA_chr14_97008580_ENST00000216277_length(transcript)=4211nt_BP=1027nt
CTCAACCAGCCACTGCTGGATGTGGACCACACATCTTCAAGACTTAATCTTTTGACACCTCGACATTTGAATCAGAAGGGGAAAGCGCTT
CCTTTAAGCAGTGCTGAGAAGAGGAAAGCCAAATGGGAAAGTCTGCAGAATAAACAGATACTGGTTCCAGAACTCTGTGCTATACATCCA
ATTCCAGCATCACTGTGGAGAAAAGCTGTTTGTCTCCCCAGCATACTTTATCGCCTTCACTGCCTTTTGACTGCAGAGGAGCTAAGAGCC
CAGACTGCCAGCGATGCTGGCGTGGGAGTCAGATCACTTCCTGCGGATTTTAGCTGAAAATGATAATTACTGTAAGCACAGCACAATTGT
CCCTGAAAATGCTGCACATCAAGGTGCTAATAGAACCTCCTCTCTAGAAAATCATGACCAAATGTCTGTGAACTGCAGAACGTTGCTCAG
CGAGTCCCCTGGTAAGCTCCACGTTGAAGTTTCAGCAGATCTTACAGCAATTAATGGTCTTTCTTACAATCAAAATCTCGCCAATGGCAG
TTATGATTTAGCTAACAGAGACTTTTGCCAAGGAAATCAGCTAAATTACTACAAGCAGGAAATACCCGTGCAACCAACTACCTCATATTC
CATTCAGAATTTATACAGTTACGAGAACCAGCCCCAGCCCAGCGATGAATGTACTCTCCTGAGTAATAAATACCTTGATGGAAATGCTAA
CAAATCTACCTCAGATGGAAGTCCTGTGATGGCCGTAATGCCTGGTACGACAGACACTATTCAAGTGCTCAAGGGCAGGATGGATTCTGA
GCAGAGCCCTTCTATTGGGTACTCCTCAAGGACTCTTGGCCCCAATCCTGGACTTATTCTTCAGGCTTTGACTCTGTCAAACGCTAGTGA
TGGATTTAACCTGGAGCGGCTTGAAATGCTTGGCGACTCCTTTTTAAAGCATGCCATCACCACATATCTATTTTGCACTTACCCTGATGC
GCATGAGGGCCGCCTTTCATATATGAGAAGCAAAAAGGCATTATATTGTACTTCTAGCAAGTGCACCAACAGAAAAACAACGCCTGGAAT
GGGTGGGCTTGGTGGAATCAAAAATCCGAATCCTGGTTGGAAGCTTGGAGAAGAATGAATTTATTACACTGGCTCATGTGAATCCCCAGT
CATTTCCAGCACCCAAAGAAAATCCCGACAAGGAAGAATTTCGCACGATGTGGGTGATTGGGTTAGTGTTTAAAAAAACAGAAAACTCTG
AAAACCTCAGTGTTGATCTCACCTATGATATTCAGTCTTTCACAGATACAGTTTATAGGCAAGCAATAAACAGCAAGATGTTTGAGGTGG
ATATGAAAATTGCTGCAATGCATGTAAAAAGAAAGCAACTCCATCAACTACTACCTAATCATGTGCTTCAGAAAAAGAAAAAGCATTCAA
CAGAAGGTGTCAAATTGACAGCTCTCAATGACAGCAGCCTCGACTTGTCTATGGACAGTGATAACAGCATGTCTGTGCCTTCACCTACTA
GTGCTACGAAGACCAGTCCATTGAACAGTTCTGGCAGCTCTCAGGGCAGAAACAGTCCTGCTCCAGCTGTAACAGCAGCATCTGTGACCA
ACATACAGGCTACTGAAGTTTCTGTGCCACAAGTAAATTCCAGTGAAAGCTCAGGGGGTACATCGAGTGAAAGCATTCCTCAAACTGCCA
CACAACCAGCCATTTCTCCACCACCAAAGCCTACGGTCTCCAGAGTTGTTTCTTCAACACGTCTGGTAAACCCACCACCTAGATCTTCAG
GAAATGCAGCAACTTCAGGAAATGCAGCAACAAAAATACCTACTCCTATAGTAGGAGTCAAGAGGACATCCTCACCTCATAAAGAAGAGA
GTCCCAAGAAAACCAAAACAGAAGAGGATGAAACAAGTGAAGATGCTAACTGTCTTGCTTTGAGTGGACATGATAAAACAGAAGCAAAGG
AACAACTTGATACAGAGACAAGTACAACTCAATCAGAAACTATTCAGACAGCGGCTTCTCTGTTGGCCTCTCAGAAAACATCCAGTACAG
ACCTTTCTGATATCCCTGCTCTCCCTGCAAATCCTATTCCTGTTATCAAGAATTCAATAAAACTGAGATTGAATCGGTAAAAACAACCTC
AGGGGTCCATAAACAATATCTGCCAACTCAACCTGTTGTCTTCAAATGCTAAAAAAGGAGAATGGAGGGTACAAGACTAGACATGACTGA
AATGGATTTGGGTTTTTTGGTGACCTCCCTTACTGGGCTAATCAGCACTTGATCGGAAGTCCAGGTTAGTATGTGAAGCCAGGAGTACTA
TTATTATTGTGTTAGCAACAGTTGCATTAACTATTTCAAAAATTACTGCCTTTAAAAAAAACAACCTCAAGCTATATTTGTATTCATAAT
TGACATCTGGATTGGGTTTATGTTTGATGCATTGTTTGGAAAATTTGCAATACAAACTGGCATAAGAATTACTTATTCTGATGATGCACT
TTTATGTATTTTTCATTAGAAAGTAGAACTAATTTTAGATTTTCAGCTTGATGGATTTTCAGTTTTTCCTGAAGAATTTTCTTTACCATT
AGTCTTCAAATTGGATACTGTTGTGCAGTGGTGTACTGTTATACTTCAGAGAAAGGGTAAGAGTACATCTAGTTCAGTTCCTATGAGGTA
GCTGTAACCCTTAAAAATGAAACGTCAACTCTAGGGTACATTTGACATTGAAAGAATAGTTAGGAAATAACTTGGTTTTGATAGGGTCAT
GATTAAGAAATGATATATTGGTTTTATTTATGGAATTGTTTTATAGTGCATACAAATCAGCGATCAGCCAGCAAATATTTTTCTTTGAGC
TTGTGAAAGCTCTGTGTTCTTTTGCCTTCAATCTGTTGTCTTCAAAACAAACAAACAAAAAAAGCTTCTTGCGCCTTTCCCTCCCCTGTT
TTCTTCCTTTTTCTTTTTGCTTGTATGCACAAGGTAGGACTTACTTCGTAAGAAACAAAATGCCAGTATTTTCTTAAGCCATGATGTGAA
ACCAATGACCCTGTGACCACATGGCACAGAACACTAAATTTTGGTCCCATGGCTGAAACTTGAGGGTGACTAAAAGTAATGCCTGTGAAA
CATGATATCTATCTGGGATGGCCATTTGATCTCTAAAAGGAATTTTGTACACTCCACAGAACTCCTATCTATAGTAAAATTGATTTTCAG
TTTTAAATGTGGGCAAAAAGGCATTTTCTCCAAGATTTTAAAACTAATTCTTATTTTTAAATGGTTTACCAAAATTTGTCAGTACATTTT
ACGTGTAGAAGCATTTTAAAAATCATTTCTAGCAAGCACTTGACATCTAGTCAGCTCTCTACTCCTTTATTTTGTTTTATCAAAAGATTA
AGAGCTCCTTTCTTTGAATAAAATAATTTCTCATAATTAAGCAGTAGAAGATCTATCTTCACAAAGTATGAGGGATGCCAGATGTTGATA
AACTTACTCTTTCTGAATCTGGACAAAGTCGACTTAACAGATTTTTCTGATGAGCATGTTTTATGAATCCTCCATTGTGCTCCATTCTAT
CACATGTGCATTTTTCATGTTAAACTGCAATTACTTAATCTCTTCCCCTATCCTTCTAAATTAATTTTCTGAAGTTGGAGTGTAGTCTTT
TCCCCCTTAGGCTATGCATTAATCGAAGCTTTCTTTTCACCATGACTTTATAATGTCTAGTAAACAATATTTCTACTTCCCACATCTTTG
CTTTACACAGTCACCTTGCCCTTCCTTCCACCACCGAAGAAAAAAGATGGTCATACTAACAGGTGAAATGTACAAGGTGTCTGTGTGTTT
TGTGTAGCTTCAGAGTTAGATTGAAATTACCAGGCACAGATTTAGTCTTGTCATTTTGTTTACACATTGGGGAAAACAATTCAGTTTATT
AAACGTTTCATGTAACTGCACCCAAGTTTTGCCAAGCTGGAAACTTGGACCTTTTCTGTGTAGTGACTTTTTAATTATAGTTTTCATAAC
CTGGAGATCAGACTGTTGCTTTCGCATGATGTATGTAGTGTCTCATGACTGGAGTTTGCTTTGTTTTATAGTATCTGTACTCCTTGTATT

>22793_22793_1_DICER1-PAPOLA_DICER1_chr14_95569683_ENST00000556045_PAPOLA_chr14_97008580_ENST00000216277_length(amino acids)=358AA_BP=
MEWVGLVESKIRILVGSLEKNEFITLAHVNPQSFPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMF
EVDMKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTSATKTSPLNSSGSSQGRNSPAPAVTAAS
VTNIQATEVSVPQVNSSESSGGTSSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHK

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Fusion Gene PPI Analysis for DICER1-PAPOLA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DICER1-PAPOLA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DICER1-PAPOLA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource