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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DIP2A-PTGES3 (FusionGDB2 ID:22832)

Fusion Gene Summary for DIP2A-PTGES3

check button Fusion gene summary
Fusion gene informationFusion gene name: DIP2A-PTGES3
Fusion gene ID: 22832
HgeneTgene
Gene symbol

DIP2A

PTGES3

Gene ID

23181

10728

Gene namedisco interacting protein 2 homolog Aprostaglandin E synthase 3
SynonymsC21orf106|DIP2P23|TEBP|cPGES
Cytomap

21q22.3

12q13.3|12

Type of geneprotein-codingprotein-coding
Descriptiondisco-interacting protein 2 homolog ADIP2 disco-interacting protein 2 homolog ADIP2 homolog Adisco-interacting protein 2Aprostaglandin E synthase 3Hsp90 co-chaperonecytosolic prostaglandin E synthasecytosolic prostaglandin E2 synthaseprogesterone receptor complex p23prostaglandin E synthase 3 (cytosolic)telomerase-binding protein p23unactive progesterone receptor, 23
Modification date2020031320200313
UniProtAcc

Q14689

.
Ensembl transtripts involved in fusion geneENST00000318711, ENST00000400274, 
ENST00000417564, ENST00000427143, 
ENST00000435722, ENST00000457905, 
ENST00000466639, ENST00000479654, 
ENST00000537473, ENST00000414274, 
ENST00000436399, ENST00000448157, 
ENST00000456859, ENST00000262033, 
Fusion gene scores* DoF score14 X 14 X 8=15688 X 9 X 4=288
# samples 1310
** MAII scorelog2(13/1568*10)=-3.59234203108675
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DIP2A [Title/Abstract] AND PTGES3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDIP2A(47949096)-PTGES3(57064148), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDIP2A

GO:0010629

negative regulation of gene expression

20860622

TgenePTGES3

GO:0001516

prostaglandin biosynthetic process

10922363

TgenePTGES3

GO:0007004

telomere maintenance via telomerase

10197982|19740745

TgenePTGES3

GO:0042327

positive regulation of phosphorylation

19740745

TgenePTGES3

GO:0051085

chaperone cofactor-dependent protein refolding

12853476

TgenePTGES3

GO:0051973

positive regulation of telomerase activity

10197982|19740745

TgenePTGES3

GO:1905323

telomerase holoenzyme complex assembly

10197982


check buttonFusion gene breakpoints across DIP2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PTGES3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-B7-A5TJDIP2Achr21

47949096

+PTGES3chr12

57064148

-


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Fusion Gene ORF analysis for DIP2A-PTGES3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000318711ENST00000537473DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-5UTRENST00000400274ENST00000537473DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-5UTRENST00000417564ENST00000537473DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-5UTRENST00000427143ENST00000537473DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-5UTRENST00000435722ENST00000537473DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-5UTRENST00000457905ENST00000537473DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-5UTRENST00000466639ENST00000537473DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000318711ENST00000414274DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000318711ENST00000436399DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000318711ENST00000448157DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000318711ENST00000456859DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000400274ENST00000414274DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000400274ENST00000436399DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000400274ENST00000448157DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000400274ENST00000456859DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000417564ENST00000414274DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000417564ENST00000436399DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000417564ENST00000448157DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000417564ENST00000456859DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000427143ENST00000414274DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000427143ENST00000436399DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000427143ENST00000448157DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000427143ENST00000456859DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000435722ENST00000414274DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000435722ENST00000436399DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000435722ENST00000448157DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000435722ENST00000456859DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000457905ENST00000414274DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000457905ENST00000436399DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000457905ENST00000448157DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000457905ENST00000456859DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000466639ENST00000414274DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000466639ENST00000436399DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000466639ENST00000448157DIP2Achr21

47949096

+PTGES3chr12

57064148

-
5CDS-intronENST00000466639ENST00000456859DIP2Achr21

47949096

+PTGES3chr12

57064148

-
In-frameENST00000318711ENST00000262033DIP2Achr21

47949096

+PTGES3chr12

57064148

-
In-frameENST00000400274ENST00000262033DIP2Achr21

47949096

+PTGES3chr12

57064148

-
In-frameENST00000417564ENST00000262033DIP2Achr21

47949096

+PTGES3chr12

57064148

-
In-frameENST00000427143ENST00000262033DIP2Achr21

47949096

+PTGES3chr12

57064148

-
In-frameENST00000435722ENST00000262033DIP2Achr21

47949096

+PTGES3chr12

57064148

-
In-frameENST00000457905ENST00000262033DIP2Achr21

47949096

+PTGES3chr12

57064148

-
In-frameENST00000466639ENST00000262033DIP2Achr21

47949096

+PTGES3chr12

57064148

-
intron-3CDSENST00000479654ENST00000262033DIP2Achr21

47949096

+PTGES3chr12

57064148

-
intron-5UTRENST00000479654ENST00000537473DIP2Achr21

47949096

+PTGES3chr12

57064148

-
intron-intronENST00000479654ENST00000414274DIP2Achr21

47949096

+PTGES3chr12

57064148

-
intron-intronENST00000479654ENST00000436399DIP2Achr21

47949096

+PTGES3chr12

57064148

-
intron-intronENST00000479654ENST00000448157DIP2Achr21

47949096

+PTGES3chr12

57064148

-
intron-intronENST00000479654ENST00000456859DIP2Achr21

47949096

+PTGES3chr12

57064148

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000400274DIP2Achr2147949096+ENST00000262033PTGES3chr1257064148-274914151221612496
ENST00000427143DIP2Achr2147949096+ENST00000262033PTGES3chr1257064148-25261192791389436
ENST00000318711DIP2Achr2147949096+ENST00000262033PTGES3chr1257064148-27141380721577501
ENST00000417564DIP2Achr2147949096+ENST00000262033PTGES3chr1257064148-25491215151412465
ENST00000457905DIP2Achr2147949096+ENST00000262033PTGES3chr1257064148-27101376711573500
ENST00000466639DIP2Achr2147949096+ENST00000262033PTGES3chr1257064148-25541220441417457
ENST00000435722DIP2Achr2147949096+ENST00000262033PTGES3chr1257064148-26031269691466465

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000400274ENST00000262033DIP2Achr2147949096+PTGES3chr1257064148-0.0013642240.9986357
ENST00000427143ENST00000262033DIP2Achr2147949096+PTGES3chr1257064148-0.0008111860.99918884
ENST00000318711ENST00000262033DIP2Achr2147949096+PTGES3chr1257064148-0.0015178260.99848217
ENST00000417564ENST00000262033DIP2Achr2147949096+PTGES3chr1257064148-0.0012711980.9987288
ENST00000457905ENST00000262033DIP2Achr2147949096+PTGES3chr1257064148-0.0013805340.99861944
ENST00000466639ENST00000262033DIP2Achr2147949096+PTGES3chr1257064148-0.0009357630.99906427
ENST00000435722ENST00000262033DIP2Achr2147949096+PTGES3chr1257064148-0.0013155250.99868447

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Fusion Genomic Features for DIP2A-PTGES3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DIP2A-PTGES3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:47949096/chr12:57064148)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DIP2A

Q14689

.
FUNCTION: Catalyzes the de novo synthesis of acetyl-CoA in vitro (By similarity). Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity). Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (PubMed:20054002). {ECO:0000250|UniProtKB:Q8BWT5, ECO:0000269|PubMed:20054002}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDIP2Achr21:47949096chr12:57064148ENST00000400274+9389_1273941568.0DomainDMAP1-binding
HgeneDIP2Achr21:47949096chr12:57064148ENST00000417564+9389_1273981572.0DomainDMAP1-binding
HgeneDIP2Achr21:47949096chr12:57064148ENST00000427143+7289_1273341111.0DomainDMAP1-binding
HgeneDIP2Achr21:47949096chr12:57064148ENST00000435722+9219_127398842.0DomainDMAP1-binding
HgeneDIP2Achr21:47949096chr12:57064148ENST00000457905+9229_127398890.0DomainDMAP1-binding
HgeneDIP2Achr21:47949096chr12:57064148ENST00000466639+8209_127355799.0DomainDMAP1-binding
TgenePTGES3chr21:47949096chr12:57064148ENST0000026203338108_16095161.0Compositional biasNote=Asp/Glu-rich
TgenePTGES3chr21:47949096chr12:57064148ENST0000026203338157_16095161.0MotifPXLE motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDIP2Achr21:47949096chr12:57064148ENST00000400274+9381114_11173941568.0Compositional biasNote=Poly-Ala
HgeneDIP2Achr21:47949096chr12:57064148ENST00000400274+9381498_15013941568.0Compositional biasNote=Poly-Val
HgeneDIP2Achr21:47949096chr12:57064148ENST00000417564+9381114_11173981572.0Compositional biasNote=Poly-Ala
HgeneDIP2Achr21:47949096chr12:57064148ENST00000417564+9381498_15013981572.0Compositional biasNote=Poly-Val
HgeneDIP2Achr21:47949096chr12:57064148ENST00000427143+7281114_11173341111.0Compositional biasNote=Poly-Ala
HgeneDIP2Achr21:47949096chr12:57064148ENST00000427143+7281498_15013341111.0Compositional biasNote=Poly-Val
HgeneDIP2Achr21:47949096chr12:57064148ENST00000435722+9211114_1117398842.0Compositional biasNote=Poly-Ala
HgeneDIP2Achr21:47949096chr12:57064148ENST00000435722+9211498_1501398842.0Compositional biasNote=Poly-Val
HgeneDIP2Achr21:47949096chr12:57064148ENST00000457905+9221114_1117398890.0Compositional biasNote=Poly-Ala
HgeneDIP2Achr21:47949096chr12:57064148ENST00000457905+9221498_1501398890.0Compositional biasNote=Poly-Val
HgeneDIP2Achr21:47949096chr12:57064148ENST00000466639+8201114_1117355799.0Compositional biasNote=Poly-Ala
HgeneDIP2Achr21:47949096chr12:57064148ENST00000466639+8201498_1501355799.0Compositional biasNote=Poly-Val
TgenePTGES3chr21:47949096chr12:57064148ENST00000262033381_9095161.0DomainCS


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Fusion Gene Sequence for DIP2A-PTGES3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22832_22832_1_DIP2A-PTGES3_DIP2A_chr21_47949096_ENST00000318711_PTGES3_chr12_57064148_ENST00000262033_length(transcript)=2714nt_BP=1380nt
TCCGCGCTCGTGCCCGCGCGGGTGCGTTGCTGTCCTGGCCGCGCCCCTGTCCCGCCGCCTCCCGCTCCTCGCCTGGCGGATGTAGGTTGT
TGGCCTGAGGGGAGCTACGTAGCCGAGGTTTGCGCTGCCGCCGCCAGGCCCGGTCCGGTTCCAGCCTCTGCCCGGACGCTAGCCGGCCTG
GCCATGGCTGACCGCGGGTGCCCGCTGGAGGCGGCGCCGCTGCCTGCCGAGGTGCGGGAGAGCCTGGCTGAGCTGGAGCTGGAGCTGTCG
GAAGGTGACATCACTCAAAAAGGATATGAAAAGAAAAGGGCAAAGCTGCTTGCACGTTATATACCGCTTATTCAAGGAATAGACCCATCT
CTGCAAGCAGAGAATAGAATTCCTGGGCCCTCACAAACCACGGCCGCTGCACCCAAGCAGCAGAAGTCTCGGCCCACCGCCTCGAGGGAT
GAGCGCTTCCGGTCAGATGTCCACACTGAAGCCGTGCAAGCAGCTTTGGCCAAATACAAAGAGAGGAAGATGCCTATGCCTTCGAAGAGA
CGTTCTGTCCTTGTGCATTCGTCTGTGGAAACCTACACCCCTCCAGACACGTCGTCTGCCTCAGAAGATGAGGGCTCTTTACGGCGACCC
GGGCGACTCACCTCCACTCCGCTCCAGAGCCATTCCAGCGTCGAGCCCTGGCTCGACCGGGTCATTCAGGGCTCGTCCACCTCATCCTCT
GCATCCTCCACCTCATCTCACCCGGGAGGGAGACCCACCACTGCTCCCAGTGCTGCAGCCACGCCGGGGGCCGCCGCTACCACTGCACTC
GCAGGCCTCGAGGCCCACACCCACATAGCAGATCTGCATTCTGCCCCTCCTGATGTCACCACGGGCCTCGTGGAGCATTCGTACTTTGAG
CGTCCACAGGTGGCTTCTGTGAGAAGTGTTCCTCGGGGGTGCAGCGGGAGCATGCTGGAAACAGCAGATGGTGTCCCTGTGAACAGCAGA
GTGTCCTCCAAAATCCAGCAGCTTCTGAACACCCTGAAGAGGCCAAAGCGCCCTCCACTGAAGGAGTTCTTTGTGGATGATTTTGAGGAA
TTGTTGGAAGTTCAGCAACCAGATCCAAATCAGCCAAAGCCTGAGGGAAGCGAGACGAGTGTGCTGAGAGGGGAGCCTCTCACTGCAGGT
GTCCCCCGACCGCCGTCGCTGTTGGCCACCTTGCAGCGCTGGGGCACAACACAGCCCAAATCCCCCTGTCTGACTGCCTTGGATACAACT
GGGAAAGCCGTCTACACTCTCACCTATGGTAAACTTTGGAGTCGGAGTTTAAAACTAGCTTATACTCTACTTAATAAACTGACAAGTAAG
AATGAACCTCTACTTAAACCTGGAGACAGACTTAATTGGCTTAGTGTCGACTTCAATAATTGGAAAGACTGGGAAGATGATTCAGATGAA
GACATGTCTAATTTTGATCGTTTCTCTGAGATGATGAACAACATGGGTGGTGATGAGGATGTAGATTTACCAGAAGTAGATGGAGCAGAT
GATGATTCACAAGACAGTGATGATGAAAAAATGCCAGATCTGGAGTAAGGAATATTGTCATCACCTGGATTTTGAGAAAGAAAAATAACT
TCTCTGCAAGATTTCATAATTGAGAGAATTCCTGAGTTGATAGCTCTAAAGGCAGATATGCTGTATTTGCCTACTTTAACCCATTTTTCA
ACCTGTTTGTTTTTTAAAAGGCTTCACTAAGGGTTGATATGTACCATTGTATGGGGCAATTTTAAGTCAGCTAAGGCAATAACCTTATGC
ATGAACATTTCCCAGACTTTCATGAAGCTGTTGAGGTCCTAGGCAATTAATGCAGCAGTTGCGATAAATAAAAACATCTCACCTAAGTCT
CCTTTTCTTCATAACATAGATACTGACATGATAGGAAGCTCTCAGCTTAGGGAAAGAGAATAAATTTTAGATTATAGAACATGGATTCAA
AAGTGACTGGAACAAATTGGCTGACACCTTACTGGTAACCTGCTATTCTTCTGGTGTTATCCTTCAGGATTGTTCCACTAAAATTTATTT
TTCAAAAAATTTACTTCACATTATTCTATGTAAGTGATGACTTGTCAGTGTTCCAGGTGTATCTTAGCTAAAACTAGAGAATGCCCTAAC
TTAGATGGTTTTTGAAGCCTATACAATTGGTATTGTTTGACCCTTAAGCTTTTACATCTCTTAGCATGGAGGACGAAGAAAGCTGTACAT
TGTTGCTTGAGAGTCTGTACATTTAGTCCAGATTTGTATTTGCACTGTCAGTATGGCAAATGAGTGAAAAATGTTTAATACACTATTGGA
TTTTTTATTTCCTTTTTTTGATTCAGCTTATACCCGGGCTGAAAACCTCAATTTATGTTCATGACAGTGGGGATTTTTTTAAATGTCTAC
ATTCTTTCTAATAAACTGTTGGAAGACTTCTTGGCTGTCCTTTTAAGTGTCTGGCTTACTGTAATTTTTATGTATTTACCATTTACTGGA
ATGGAGTTTATTTGAGGAAGAATTTGGGATTATTCCTCTGTTTGAAAAAAGAGGCTTGCTGTAATGTCACAGGAAACCTTTTAAAAGTGG
ATCTGTAATAGCATATTGTAGATGCACTTTGCAGCAGTTGGAAAAGAAAGTGTTGTGTGATTTGATTGAAATAAAACTAAATGTGTTGTC

>22832_22832_1_DIP2A-PTGES3_DIP2A_chr21_47949096_ENST00000318711_PTGES3_chr12_57064148_ENST00000262033_length(amino acids)=501AA_BP=436
MADVGCWPEGSYVAEVCAAAARPGPVPASARTLAGLAMADRGCPLEAAPLPAEVRESLAELELELSEGDITQKGYEKKRAKLLARYIPLI
QGIDPSLQAENRIPGPSQTTAAAPKQQKSRPTASRDERFRSDVHTEAVQAALAKYKERKMPMPSKRRSVLVHSSVETYTPPDTSSASEDE
GSLRRPGRLTSTPLQSHSSVEPWLDRVIQGSSTSSSASSTSSHPGGRPTTAPSAAATPGAAATTALAGLEAHTHIADLHSAPPDVTTGLV
EHSYFERPQVASVRSVPRGCSGSMLETADGVPVNSRVSSKIQQLLNTLKRPKRPPLKEFFVDDFEELLEVQQPDPNQPKPEGSETSVLRG
EPLTAGVPRPPSLLATLQRWGTTQPKSPCLTALDTTGKAVYTLTYGKLWSRSLKLAYTLLNKLTSKNEPLLKPGDRLNWLSVDFNNWKDW

--------------------------------------------------------------
>22832_22832_2_DIP2A-PTGES3_DIP2A_chr21_47949096_ENST00000400274_PTGES3_chr12_57064148_ENST00000262033_length(transcript)=2749nt_BP=1415nt
CCGGCCGGGCGCTCAGGAGCGCGCGGGGCAGCGGCGGCGCGGCGGAGCCATCCGCGCTCGTGCCCGCGCGGGTGCGTTGCTGTCCTGGCC
GCGCCCCTGTCCCGCCGCCTCCCGCTCCTCGCCTGGCGGATGTAGGTTGTTGGCCTGAGGGGAGCTACGTAGCCGAGGTTTGCGCTGCCG
CCGCCAGGCCCGGTCCGGTTCCAGCCTCTGCCCGGACGCTAGCCGGCCTGGCCATGGCTGACCGCGGGTGCCCGCTGGAGGCGGCGCCGC
TGCCTGCCGAGGTGCGGGAGAGCCTGGCTGAGCTGGAGCTGGAGCTGTCGGAAGGTGACATCACTCAAAAAGGATATGAAAAGAAAAGGG
CAAAGCTGCTTGCACGTTATATACCGCTTATTCAAGGAATAGACCCATCTCTGCAAGCAGAGAATAGAATTCCTGGGCCCTCACAAACCA
CGGCCGCTGCACCCAAGCAGCAGAAGTCTCGGCCCACCGCCTCGAGGGATGAGCGCTTCCGGTCAGATGTCCACACTGAAGCCGTGCAAG
CAGCTTTGGCCAAATACAAAGAGAGGAAGATGCCTATGCCTTCGAAGAGACGTTCTGTCCTTGTGCATTCGTCTGTGGAAACCTACACCC
CTCCAGACACGTCGTCTGCCTCAGAAGATGAGGGCTCTTTACGGCGACCCGGGCGACTCACCTCCACTCCGCTCCAGAGCCATTCCAGCG
TCGAGCCCTGGCTCGACCGGGTCATTCAGGGCTCGTCCACCTCATCCTCTGCATCCTCCACCTCATCTCACCCGGGAGGGAGACCCACCA
CTGCTCCCAGTGCTGCAGCCACGCCGGGGGCCGCCGCTACCACTGCACTCGCAGGCCTCGAGGCCCACACCCACATAGATCTGCATTCTG
CCCCTCCTGATGTCACCACGGGCCTCGTGGAGCATTCGTACTTTGAGCGTCCACAGGTGGCTTCTGTGAGAAGTGTTCCTCGGGGGTGCA
GCGGGAGCATGCTGGAAACAGCAGATGGTGTCCCTGTGAACAGCAGAGTGTCCTCCAAAATCCAGCAGCTTCTGAACACCCTGAAGAGGC
CAAAGCGCCCTCCACTGAAGGAGTTCTTTGTGGATGATTTTGAGGAATTGTTGGAAGATCCAAATCAGCCAAAGCCTGAGGGAAGCGAGA
CGAGTGTGCTGAGAGGGGAGCCTCTCACTGCAGGTGTCCCCCGACCGCCGTCGCTGTTGGCCACCTTGCAGCGCTGGGGCACAACACAGC
CCAAATCCCCCTGTCTGACTGCCTTGGATACAACTGGGAAAGCCGTCTACACTCTCACCTATGGTAAACTTTGGAGTCGGAGTTTAAAAC
TAGCTTATACTCTACTTAATAAACTGACAAGTAAGAATGAACCTCTACTTAAACCTGGAGACAGACTTAATTGGCTTAGTGTCGACTTCA
ATAATTGGAAAGACTGGGAAGATGATTCAGATGAAGACATGTCTAATTTTGATCGTTTCTCTGAGATGATGAACAACATGGGTGGTGATG
AGGATGTAGATTTACCAGAAGTAGATGGAGCAGATGATGATTCACAAGACAGTGATGATGAAAAAATGCCAGATCTGGAGTAAGGAATAT
TGTCATCACCTGGATTTTGAGAAAGAAAAATAACTTCTCTGCAAGATTTCATAATTGAGAGAATTCCTGAGTTGATAGCTCTAAAGGCAG
ATATGCTGTATTTGCCTACTTTAACCCATTTTTCAACCTGTTTGTTTTTTAAAAGGCTTCACTAAGGGTTGATATGTACCATTGTATGGG
GCAATTTTAAGTCAGCTAAGGCAATAACCTTATGCATGAACATTTCCCAGACTTTCATGAAGCTGTTGAGGTCCTAGGCAATTAATGCAG
CAGTTGCGATAAATAAAAACATCTCACCTAAGTCTCCTTTTCTTCATAACATAGATACTGACATGATAGGAAGCTCTCAGCTTAGGGAAA
GAGAATAAATTTTAGATTATAGAACATGGATTCAAAAGTGACTGGAACAAATTGGCTGACACCTTACTGGTAACCTGCTATTCTTCTGGT
GTTATCCTTCAGGATTGTTCCACTAAAATTTATTTTTCAAAAAATTTACTTCACATTATTCTATGTAAGTGATGACTTGTCAGTGTTCCA
GGTGTATCTTAGCTAAAACTAGAGAATGCCCTAACTTAGATGGTTTTTGAAGCCTATACAATTGGTATTGTTTGACCCTTAAGCTTTTAC
ATCTCTTAGCATGGAGGACGAAGAAAGCTGTACATTGTTGCTTGAGAGTCTGTACATTTAGTCCAGATTTGTATTTGCACTGTCAGTATG
GCAAATGAGTGAAAAATGTTTAATACACTATTGGATTTTTTATTTCCTTTTTTTGATTCAGCTTATACCCGGGCTGAAAACCTCAATTTA
TGTTCATGACAGTGGGGATTTTTTTAAATGTCTACATTCTTTCTAATAAACTGTTGGAAGACTTCTTGGCTGTCCTTTTAAGTGTCTGGC
TTACTGTAATTTTTATGTATTTACCATTTACTGGAATGGAGTTTATTTGAGGAAGAATTTGGGATTATTCCTCTGTTTGAAAAAAGAGGC
TTGCTGTAATGTCACAGGAAACCTTTTAAAAGTGGATCTGTAATAGCATATTGTAGATGCACTTTGCAGCAGTTGGAAAAGAAAGTGTTG

>22832_22832_2_DIP2A-PTGES3_DIP2A_chr21_47949096_ENST00000400274_PTGES3_chr12_57064148_ENST00000262033_length(amino acids)=496AA_BP=431
MADVGCWPEGSYVAEVCAAAARPGPVPASARTLAGLAMADRGCPLEAAPLPAEVRESLAELELELSEGDITQKGYEKKRAKLLARYIPLI
QGIDPSLQAENRIPGPSQTTAAAPKQQKSRPTASRDERFRSDVHTEAVQAALAKYKERKMPMPSKRRSVLVHSSVETYTPPDTSSASEDE
GSLRRPGRLTSTPLQSHSSVEPWLDRVIQGSSTSSSASSTSSHPGGRPTTAPSAAATPGAAATTALAGLEAHTHIDLHSAPPDVTTGLVE
HSYFERPQVASVRSVPRGCSGSMLETADGVPVNSRVSSKIQQLLNTLKRPKRPPLKEFFVDDFEELLEDPNQPKPEGSETSVLRGEPLTA
GVPRPPSLLATLQRWGTTQPKSPCLTALDTTGKAVYTLTYGKLWSRSLKLAYTLLNKLTSKNEPLLKPGDRLNWLSVDFNNWKDWEDDSD

--------------------------------------------------------------
>22832_22832_3_DIP2A-PTGES3_DIP2A_chr21_47949096_ENST00000417564_PTGES3_chr12_57064148_ENST00000262033_length(transcript)=2549nt_BP=1215nt
CGGACGCTAGCCGGCCTGGCCATGGCTGACCGCGGGTGCCCGCTGGAGGCGGCGCCGCTGCCTGCCGAGGTGCGGGAGAGCCTGGCTGAG
CTGGAGCTGGAGCTGTCGGAAGGTGACATCACTCAAAAAGGATATGAAAAGAAAAGGGCAAAGCTGCTTGCACGTTATATACCGCTTATT
CAAGGAATAGACCCATCTCTGCAAGCAGAGAATAGAATTCCTGGGCCCTCACAAACCACGGCCGCTGCACCCAAGCAGCAGAAGTCTCGG
CCCACCGCCTCGAGGGATGAGCGCTTCCGGTCAGATGTCCACACTGAAGCCGTGCAAGCAGCTTTGGCCAAATACAAAGAGAGGAAGATG
CCTATGCCTTCGAAGAGACGTTCTGTCCTTGTGCATTCGTCTGTGGAAACCTACACCCCTCCAGACACGTCGTCTGCCTCAGAAGATGAG
GGCTCTTTACGGCGACCCGGGCGACTCACCTCCACTCCGCTCCAGAGCCATTCCAGCGTCGAGCCCTGGCTCGACCGGGTCATTCAGGGC
TCGTCCACCTCATCCTCTGCATCCTCCACCTCATCTCACCCGGGAGGGAGACCCACCACTGCTCCCAGTGCTGCAGCCACGCCGGGGGCC
GCCGCTACCACTGCACTCGCAGGCCTCGAGGCCCACACCCACATAGATCTGCATTCTGCCCCTCCTGATGTCACCACGGGCCTCGTGGAG
CATTCGTACTTTGAGCGTCCACAGGTGGCTTCTGTGAGAAGTGTTCCTCGGGGGTGCAGCGGGAGCATGCTGGAAACAGCAGATGGTGTC
CCTGTGAACAGCAGAGTGTCCTCCAAAATCCAGCAGCTTCTGAACACCCTGAAGAGGCCAAAGCGCCCTCCACTGAAGGAGTTCTTTGTG
GATGATTTTGAGGAATTGTTGGAAGTTCAGCAACCAGATCCAAATCAGCCAAAGCCTGAGGGAAGCGAGACGAGTGTGCTGAGAGGGGAG
CCTCTCACTGCAGGTGTCCCCCGACCGCCGTCGCTGTTGGCCACCTTGCAGCGCTGGGGCACAACACAGCCCAAATCCCCCTGTCTGACT
GCCTTGGATACAACTGGGAAAGCCGTCTACACTCTCACCTATGGTAAACTTTGGAGTCGGAGTTTAAAACTAGCTTATACTCTACTTAAT
AAACTGACAAGTAAGAATGAACCTCTACTTAAACCTGGAGACAGACTTAATTGGCTTAGTGTCGACTTCAATAATTGGAAAGACTGGGAA
GATGATTCAGATGAAGACATGTCTAATTTTGATCGTTTCTCTGAGATGATGAACAACATGGGTGGTGATGAGGATGTAGATTTACCAGAA
GTAGATGGAGCAGATGATGATTCACAAGACAGTGATGATGAAAAAATGCCAGATCTGGAGTAAGGAATATTGTCATCACCTGGATTTTGA
GAAAGAAAAATAACTTCTCTGCAAGATTTCATAATTGAGAGAATTCCTGAGTTGATAGCTCTAAAGGCAGATATGCTGTATTTGCCTACT
TTAACCCATTTTTCAACCTGTTTGTTTTTTAAAAGGCTTCACTAAGGGTTGATATGTACCATTGTATGGGGCAATTTTAAGTCAGCTAAG
GCAATAACCTTATGCATGAACATTTCCCAGACTTTCATGAAGCTGTTGAGGTCCTAGGCAATTAATGCAGCAGTTGCGATAAATAAAAAC
ATCTCACCTAAGTCTCCTTTTCTTCATAACATAGATACTGACATGATAGGAAGCTCTCAGCTTAGGGAAAGAGAATAAATTTTAGATTAT
AGAACATGGATTCAAAAGTGACTGGAACAAATTGGCTGACACCTTACTGGTAACCTGCTATTCTTCTGGTGTTATCCTTCAGGATTGTTC
CACTAAAATTTATTTTTCAAAAAATTTACTTCACATTATTCTATGTAAGTGATGACTTGTCAGTGTTCCAGGTGTATCTTAGCTAAAACT
AGAGAATGCCCTAACTTAGATGGTTTTTGAAGCCTATACAATTGGTATTGTTTGACCCTTAAGCTTTTACATCTCTTAGCATGGAGGACG
AAGAAAGCTGTACATTGTTGCTTGAGAGTCTGTACATTTAGTCCAGATTTGTATTTGCACTGTCAGTATGGCAAATGAGTGAAAAATGTT
TAATACACTATTGGATTTTTTATTTCCTTTTTTTGATTCAGCTTATACCCGGGCTGAAAACCTCAATTTATGTTCATGACAGTGGGGATT
TTTTTAAATGTCTACATTCTTTCTAATAAACTGTTGGAAGACTTCTTGGCTGTCCTTTTAAGTGTCTGGCTTACTGTAATTTTTATGTAT
TTACCATTTACTGGAATGGAGTTTATTTGAGGAAGAATTTGGGATTATTCCTCTGTTTGAAAAAAGAGGCTTGCTGTAATGTCACAGGAA
ACCTTTTAAAAGTGGATCTGTAATAGCATATTGTAGATGCACTTTGCAGCAGTTGGAAAAGAAAGTGTTGTGTGATTTGATTGAAATAAA

>22832_22832_3_DIP2A-PTGES3_DIP2A_chr21_47949096_ENST00000417564_PTGES3_chr12_57064148_ENST00000262033_length(amino acids)=465AA_BP=400
MAMADRGCPLEAAPLPAEVRESLAELELELSEGDITQKGYEKKRAKLLARYIPLIQGIDPSLQAENRIPGPSQTTAAAPKQQKSRPTASR
DERFRSDVHTEAVQAALAKYKERKMPMPSKRRSVLVHSSVETYTPPDTSSASEDEGSLRRPGRLTSTPLQSHSSVEPWLDRVIQGSSTSS
SASSTSSHPGGRPTTAPSAAATPGAAATTALAGLEAHTHIDLHSAPPDVTTGLVEHSYFERPQVASVRSVPRGCSGSMLETADGVPVNSR
VSSKIQQLLNTLKRPKRPPLKEFFVDDFEELLEVQQPDPNQPKPEGSETSVLRGEPLTAGVPRPPSLLATLQRWGTTQPKSPCLTALDTT
GKAVYTLTYGKLWSRSLKLAYTLLNKLTSKNEPLLKPGDRLNWLSVDFNNWKDWEDDSDEDMSNFDRFSEMMNNMGGDEDVDLPEVDGAD

--------------------------------------------------------------
>22832_22832_4_DIP2A-PTGES3_DIP2A_chr21_47949096_ENST00000427143_PTGES3_chr12_57064148_ENST00000262033_length(transcript)=2526nt_BP=1192nt
GGAGCCATCCGCGCTCGTGCCCGCGCGGGTGCGTTGCTGTCCTGGCCGCGCCCCTGTCCCGCCGCCTCCCGCTCCTCGCCTGGCGGATGT
AGGTTGTTGGCCTGAGGGGAGCTACGTAGCCGAGGTTTGCGCTGCCGCCGCCAGGCCCGGTCCGGTTCCAGCCTCTGCCCGGACGCTAGC
CGGCCTGGCCATGGCTGACCGCGGGTGCCCGCTGGAGGCGGCGCCGCTGCCTGCCGAGGTGCGGGAGAGCCTGGCTGAGCTGGAGCTGGA
GCTGTCGGAAGATGTCCACACTGAAGCCGTGCAAGCAGCTTTGGCCAAATACAAAGAGAGGAAGATGCCTATGCCTTCGAAGAGACGTTC
TGTCCTTGTGCATTCGTCTGTGGAAACCTACACCCCTCCAGACACGTCGTCTGCCTCAGAAGATGAGGGCTCTTTACGGCGACCCGGGCG
ACTCACCTCCACTCCGCTCCAGAGCCATTCCAGCGTCGAGCCCTGGCTCGACCGGGTCATTCAGGGCTCGTCCACCTCATCCTCTGCATC
CTCCACCTCATCTCACCCGGGAGGGAGACCCACCACTGCTCCCAGTGCTGCAGCCACGCCGGGGGCCGCCGCTACCACTGCACTCGCAGG
CCTCGAGGCCCACACCCACATAGATCTGCATTCTGCCCCTCCTGATGTCACCACGGGCCTCGTGGAGCATTCGTACTTTGAGCGTCCACA
GGTGGCTTCTGTGAGAAGTGTTCCTCGGGGGTGCAGCGGGAGCATGCTGGAAACAGCAGATGGTGTCCCTGTGAACAGCAGAGTGTCCTC
CAAAATCCAGCAGCTTCTGAACACCCTGAAGAGGCCAAAGCGCCCTCCACTGAAGGAGTTCTTTGTGGATGATTTTGAGGAATTGTTGGA
AGTTCAGCAACCAGATCCAAATCAGCCAAAGCCTGAGGGAAGCGAGACGAGTGTGCTGAGAGGGGAGCCTCTCACTGCAGGTGTCCCCCG
ACCGCCGTCGCTGTTGGCCACCTTGCAGCGCTGGGGCACAACACAGCCCAAATCCCCCTGTCTGACTGCCTTGGATACAACTGGGAAAGC
CGTCTACACTCTCACCTATGGTAAACTTTGGAGTCGGAGTTTAAAACTAGCTTATACTCTACTTAATAAACTGACAAGTAAGAATGAACC
TCTACTTAAACCTGGAGACAGACTTAATTGGCTTAGTGTCGACTTCAATAATTGGAAAGACTGGGAAGATGATTCAGATGAAGACATGTC
TAATTTTGATCGTTTCTCTGAGATGATGAACAACATGGGTGGTGATGAGGATGTAGATTTACCAGAAGTAGATGGAGCAGATGATGATTC
ACAAGACAGTGATGATGAAAAAATGCCAGATCTGGAGTAAGGAATATTGTCATCACCTGGATTTTGAGAAAGAAAAATAACTTCTCTGCA
AGATTTCATAATTGAGAGAATTCCTGAGTTGATAGCTCTAAAGGCAGATATGCTGTATTTGCCTACTTTAACCCATTTTTCAACCTGTTT
GTTTTTTAAAAGGCTTCACTAAGGGTTGATATGTACCATTGTATGGGGCAATTTTAAGTCAGCTAAGGCAATAACCTTATGCATGAACAT
TTCCCAGACTTTCATGAAGCTGTTGAGGTCCTAGGCAATTAATGCAGCAGTTGCGATAAATAAAAACATCTCACCTAAGTCTCCTTTTCT
TCATAACATAGATACTGACATGATAGGAAGCTCTCAGCTTAGGGAAAGAGAATAAATTTTAGATTATAGAACATGGATTCAAAAGTGACT
GGAACAAATTGGCTGACACCTTACTGGTAACCTGCTATTCTTCTGGTGTTATCCTTCAGGATTGTTCCACTAAAATTTATTTTTCAAAAA
ATTTACTTCACATTATTCTATGTAAGTGATGACTTGTCAGTGTTCCAGGTGTATCTTAGCTAAAACTAGAGAATGCCCTAACTTAGATGG
TTTTTGAAGCCTATACAATTGGTATTGTTTGACCCTTAAGCTTTTACATCTCTTAGCATGGAGGACGAAGAAAGCTGTACATTGTTGCTT
GAGAGTCTGTACATTTAGTCCAGATTTGTATTTGCACTGTCAGTATGGCAAATGAGTGAAAAATGTTTAATACACTATTGGATTTTTTAT
TTCCTTTTTTTGATTCAGCTTATACCCGGGCTGAAAACCTCAATTTATGTTCATGACAGTGGGGATTTTTTTAAATGTCTACATTCTTTC
TAATAAACTGTTGGAAGACTTCTTGGCTGTCCTTTTAAGTGTCTGGCTTACTGTAATTTTTATGTATTTACCATTTACTGGAATGGAGTT
TATTTGAGGAAGAATTTGGGATTATTCCTCTGTTTGAAAAAAGAGGCTTGCTGTAATGTCACAGGAAACCTTTTAAAAGTGGATCTGTAA
TAGCATATTGTAGATGCACTTTGCAGCAGTTGGAAAAGAAAGTGTTGTGTGATTTGATTGAAATAAAACTAAATGTGTTGTCCTCCTAAA

>22832_22832_4_DIP2A-PTGES3_DIP2A_chr21_47949096_ENST00000427143_PTGES3_chr12_57064148_ENST00000262033_length(amino acids)=436AA_BP=371
MADVGCWPEGSYVAEVCAAAARPGPVPASARTLAGLAMADRGCPLEAAPLPAEVRESLAELELELSEDVHTEAVQAALAKYKERKMPMPS
KRRSVLVHSSVETYTPPDTSSASEDEGSLRRPGRLTSTPLQSHSSVEPWLDRVIQGSSTSSSASSTSSHPGGRPTTAPSAAATPGAAATT
ALAGLEAHTHIDLHSAPPDVTTGLVEHSYFERPQVASVRSVPRGCSGSMLETADGVPVNSRVSSKIQQLLNTLKRPKRPPLKEFFVDDFE
ELLEVQQPDPNQPKPEGSETSVLRGEPLTAGVPRPPSLLATLQRWGTTQPKSPCLTALDTTGKAVYTLTYGKLWSRSLKLAYTLLNKLTS

--------------------------------------------------------------
>22832_22832_5_DIP2A-PTGES3_DIP2A_chr21_47949096_ENST00000435722_PTGES3_chr12_57064148_ENST00000262033_length(transcript)=2603nt_BP=1269nt
GTAGCCGAGGTTTGCGCTGCCGCCGCCAGGCCCGGTCCGGTTCCAGCCTCTGCCCGGACGCTAGCCGGCCTGGCCATGGCTGACCGCGGG
TGCCCGCTGGAGGCGGCGCCGCTGCCTGCCGAGGTGCGGGAGAGCCTGGCTGAGCTGGAGCTGGAGCTGTCGGAAGGTGACATCACTCAA
AAAGGATATGAAAAGAAAAGGGCAAAGCTGCTTGCACGTTATATACCGCTTATTCAAGGAATAGACCCATCTCTGCAAGCAGAGAATAGA
ATTCCTGGGCCCTCACAAACCACGGCCGCTGCACCCAAGCAGCAGAAGTCTCGGCCCACCGCCTCGAGGGATGAGCGCTTCCGGTCAGAT
GTCCACACTGAAGCCGTGCAAGCAGCTTTGGCCAAATACAAAGAGAGGAAGATGCCTATGCCTTCGAAGAGACGTTCTGTCCTTGTGCAT
TCGTCTGTGGAAACCTACACCCCTCCAGACACGTCGTCTGCCTCAGAAGATGAGGGCTCTTTACGGCGACCCGGGCGACTCACCTCCACT
CCGCTCCAGAGCCATTCCAGCGTCGAGCCCTGGCTCGACCGGGTCATTCAGGGCTCGTCCACCTCATCCTCTGCATCCTCCACCTCATCT
CACCCGGGAGGGAGACCCACCACTGCTCCCAGTGCTGCAGCCACGCCGGGGGCCGCCGCTACCACTGCACTCGCAGGCCTCGAGGCCCAC
ACCCACATAGATCTGCATTCTGCCCCTCCTGATGTCACCACGGGCCTCGTGGAGCATTCGTACTTTGAGCGTCCACAGGTGGCTTCTGTG
AGAAGTGTTCCTCGGGGGTGCAGCGGGAGCATGCTGGAAACAGCAGATGGTGTCCCTGTGAACAGCAGAGTGTCCTCCAAAATCCAGCAG
CTTCTGAACACCCTGAAGAGGCCAAAGCGCCCTCCACTGAAGGAGTTCTTTGTGGATGATTTTGAGGAATTGTTGGAAGTTCAGCAACCA
GATCCAAATCAGCCAAAGCCTGAGGGAAGCGAGACGAGTGTGCTGAGAGGGGAGCCTCTCACTGCAGGTGTCCCCCGACCGCCGTCGCTG
TTGGCCACCTTGCAGCGCTGGGGCACAACACAGCCCAAATCCCCCTGTCTGACTGCCTTGGATACAACTGGGAAAGCCGTCTACACTCTC
ACCTATGGTAAACTTTGGAGTCGGAGTTTAAAACTAGCTTATACTCTACTTAATAAACTGACAAGTAAGAATGAACCTCTACTTAAACCT
GGAGACAGACTTAATTGGCTTAGTGTCGACTTCAATAATTGGAAAGACTGGGAAGATGATTCAGATGAAGACATGTCTAATTTTGATCGT
TTCTCTGAGATGATGAACAACATGGGTGGTGATGAGGATGTAGATTTACCAGAAGTAGATGGAGCAGATGATGATTCACAAGACAGTGAT
GATGAAAAAATGCCAGATCTGGAGTAAGGAATATTGTCATCACCTGGATTTTGAGAAAGAAAAATAACTTCTCTGCAAGATTTCATAATT
GAGAGAATTCCTGAGTTGATAGCTCTAAAGGCAGATATGCTGTATTTGCCTACTTTAACCCATTTTTCAACCTGTTTGTTTTTTAAAAGG
CTTCACTAAGGGTTGATATGTACCATTGTATGGGGCAATTTTAAGTCAGCTAAGGCAATAACCTTATGCATGAACATTTCCCAGACTTTC
ATGAAGCTGTTGAGGTCCTAGGCAATTAATGCAGCAGTTGCGATAAATAAAAACATCTCACCTAAGTCTCCTTTTCTTCATAACATAGAT
ACTGACATGATAGGAAGCTCTCAGCTTAGGGAAAGAGAATAAATTTTAGATTATAGAACATGGATTCAAAAGTGACTGGAACAAATTGGC
TGACACCTTACTGGTAACCTGCTATTCTTCTGGTGTTATCCTTCAGGATTGTTCCACTAAAATTTATTTTTCAAAAAATTTACTTCACAT
TATTCTATGTAAGTGATGACTTGTCAGTGTTCCAGGTGTATCTTAGCTAAAACTAGAGAATGCCCTAACTTAGATGGTTTTTGAAGCCTA
TACAATTGGTATTGTTTGACCCTTAAGCTTTTACATCTCTTAGCATGGAGGACGAAGAAAGCTGTACATTGTTGCTTGAGAGTCTGTACA
TTTAGTCCAGATTTGTATTTGCACTGTCAGTATGGCAAATGAGTGAAAAATGTTTAATACACTATTGGATTTTTTATTTCCTTTTTTTGA
TTCAGCTTATACCCGGGCTGAAAACCTCAATTTATGTTCATGACAGTGGGGATTTTTTTAAATGTCTACATTCTTTCTAATAAACTGTTG
GAAGACTTCTTGGCTGTCCTTTTAAGTGTCTGGCTTACTGTAATTTTTATGTATTTACCATTTACTGGAATGGAGTTTATTTGAGGAAGA
ATTTGGGATTATTCCTCTGTTTGAAAAAAGAGGCTTGCTGTAATGTCACAGGAAACCTTTTAAAAGTGGATCTGTAATAGCATATTGTAG

>22832_22832_5_DIP2A-PTGES3_DIP2A_chr21_47949096_ENST00000435722_PTGES3_chr12_57064148_ENST00000262033_length(amino acids)=465AA_BP=400
MAMADRGCPLEAAPLPAEVRESLAELELELSEGDITQKGYEKKRAKLLARYIPLIQGIDPSLQAENRIPGPSQTTAAAPKQQKSRPTASR
DERFRSDVHTEAVQAALAKYKERKMPMPSKRRSVLVHSSVETYTPPDTSSASEDEGSLRRPGRLTSTPLQSHSSVEPWLDRVIQGSSTSS
SASSTSSHPGGRPTTAPSAAATPGAAATTALAGLEAHTHIDLHSAPPDVTTGLVEHSYFERPQVASVRSVPRGCSGSMLETADGVPVNSR
VSSKIQQLLNTLKRPKRPPLKEFFVDDFEELLEVQQPDPNQPKPEGSETSVLRGEPLTAGVPRPPSLLATLQRWGTTQPKSPCLTALDTT
GKAVYTLTYGKLWSRSLKLAYTLLNKLTSKNEPLLKPGDRLNWLSVDFNNWKDWEDDSDEDMSNFDRFSEMMNNMGGDEDVDLPEVDGAD

--------------------------------------------------------------
>22832_22832_6_DIP2A-PTGES3_DIP2A_chr21_47949096_ENST00000457905_PTGES3_chr12_57064148_ENST00000262033_length(transcript)=2710nt_BP=1376nt
CCGCGCTCGTGCCCGCGCGGGTGCGTTGCTGTCCTGGCCGCGCCCCTGTCCCGCCGCCTCCCGCTCCTCGCCTGGCGGATGTAGGTTGTT
GGCCTGAGGGGAGCTACGTAGCCGAGGTTTGCGCTGCCGCCGCCAGGCCCGGTCCGGTTCCAGCCTCTGCCCGGACGCTAGCCGGCCTGG
CCATGGCTGACCGCGGGTGCCCGCTGGAGGCGGCGCCGCTGCCTGCCGAGGTGCGGGAGAGCCTGGCTGAGCTGGAGCTGGAGCTGTCGG
AAGGTGACATCACTCAAAAAGGATATGAAAAGAAAAGGGCAAAGCTGCTTGCACGTTATATACCGCTTATTCAAGGAATAGACCCATCTC
TGCAAGCAGAGAATAGAATTCCTGGGCCCTCACAAACCACGGCCGCTGCACCCAAGCAGCAGAAGTCTCGGCCCACCGCCTCGAGGGATG
AGCGCTTCCGGTCAGATGTCCACACTGAAGCCGTGCAAGCAGCTTTGGCCAAATACAAAGAGAGGAAGATGCCTATGCCTTCGAAGAGAC
GTTCTGTCCTTGTGCATTCGTCTGTGGAAACCTACACCCCTCCAGACACGTCGTCTGCCTCAGAAGATGAGGGCTCTTTACGGCGACCCG
GGCGACTCACCTCCACTCCGCTCCAGAGCCATTCCAGCGTCGAGCCCTGGCTCGACCGGGTCATTCAGGGCTCGTCCACCTCATCCTCTG
CATCCTCCACCTCATCTCACCCGGGAGGGAGACCCACCACTGCTCCCAGTGCTGCAGCCACGCCGGGGGCCGCCGCTACCACTGCACTCG
CAGGCCTCGAGGCCCACACCCACATAGATCTGCATTCTGCCCCTCCTGATGTCACCACGGGCCTCGTGGAGCATTCGTACTTTGAGCGTC
CACAGGTGGCTTCTGTGAGAAGTGTTCCTCGGGGGTGCAGCGGGAGCATGCTGGAAACAGCAGATGGTGTCCCTGTGAACAGCAGAGTGT
CCTCCAAAATCCAGCAGCTTCTGAACACCCTGAAGAGGCCAAAGCGCCCTCCACTGAAGGAGTTCTTTGTGGATGATTTTGAGGAATTGT
TGGAAGTTCAGCAACCAGATCCAAATCAGCCAAAGCCTGAGGGAAGCGAGACGAGTGTGCTGAGAGGGGAGCCTCTCACTGCAGGTGTCC
CCCGACCGCCGTCGCTGTTGGCCACCTTGCAGCGCTGGGGCACAACACAGCCCAAATCCCCCTGTCTGACTGCCTTGGATACAACTGGGA
AAGCCGTCTACACTCTCACCTATGGTAAACTTTGGAGTCGGAGTTTAAAACTAGCTTATACTCTACTTAATAAACTGACAAGTAAGAATG
AACCTCTACTTAAACCTGGAGACAGACTTAATTGGCTTAGTGTCGACTTCAATAATTGGAAAGACTGGGAAGATGATTCAGATGAAGACA
TGTCTAATTTTGATCGTTTCTCTGAGATGATGAACAACATGGGTGGTGATGAGGATGTAGATTTACCAGAAGTAGATGGAGCAGATGATG
ATTCACAAGACAGTGATGATGAAAAAATGCCAGATCTGGAGTAAGGAATATTGTCATCACCTGGATTTTGAGAAAGAAAAATAACTTCTC
TGCAAGATTTCATAATTGAGAGAATTCCTGAGTTGATAGCTCTAAAGGCAGATATGCTGTATTTGCCTACTTTAACCCATTTTTCAACCT
GTTTGTTTTTTAAAAGGCTTCACTAAGGGTTGATATGTACCATTGTATGGGGCAATTTTAAGTCAGCTAAGGCAATAACCTTATGCATGA
ACATTTCCCAGACTTTCATGAAGCTGTTGAGGTCCTAGGCAATTAATGCAGCAGTTGCGATAAATAAAAACATCTCACCTAAGTCTCCTT
TTCTTCATAACATAGATACTGACATGATAGGAAGCTCTCAGCTTAGGGAAAGAGAATAAATTTTAGATTATAGAACATGGATTCAAAAGT
GACTGGAACAAATTGGCTGACACCTTACTGGTAACCTGCTATTCTTCTGGTGTTATCCTTCAGGATTGTTCCACTAAAATTTATTTTTCA
AAAAATTTACTTCACATTATTCTATGTAAGTGATGACTTGTCAGTGTTCCAGGTGTATCTTAGCTAAAACTAGAGAATGCCCTAACTTAG
ATGGTTTTTGAAGCCTATACAATTGGTATTGTTTGACCCTTAAGCTTTTACATCTCTTAGCATGGAGGACGAAGAAAGCTGTACATTGTT
GCTTGAGAGTCTGTACATTTAGTCCAGATTTGTATTTGCACTGTCAGTATGGCAAATGAGTGAAAAATGTTTAATACACTATTGGATTTT
TTATTTCCTTTTTTTGATTCAGCTTATACCCGGGCTGAAAACCTCAATTTATGTTCATGACAGTGGGGATTTTTTTAAATGTCTACATTC
TTTCTAATAAACTGTTGGAAGACTTCTTGGCTGTCCTTTTAAGTGTCTGGCTTACTGTAATTTTTATGTATTTACCATTTACTGGAATGG
AGTTTATTTGAGGAAGAATTTGGGATTATTCCTCTGTTTGAAAAAAGAGGCTTGCTGTAATGTCACAGGAAACCTTTTAAAAGTGGATCT
GTAATAGCATATTGTAGATGCACTTTGCAGCAGTTGGAAAAGAAAGTGTTGTGTGATTTGATTGAAATAAAACTAAATGTGTTGTCCTCC

>22832_22832_6_DIP2A-PTGES3_DIP2A_chr21_47949096_ENST00000457905_PTGES3_chr12_57064148_ENST00000262033_length(amino acids)=500AA_BP=435
MADVGCWPEGSYVAEVCAAAARPGPVPASARTLAGLAMADRGCPLEAAPLPAEVRESLAELELELSEGDITQKGYEKKRAKLLARYIPLI
QGIDPSLQAENRIPGPSQTTAAAPKQQKSRPTASRDERFRSDVHTEAVQAALAKYKERKMPMPSKRRSVLVHSSVETYTPPDTSSASEDE
GSLRRPGRLTSTPLQSHSSVEPWLDRVIQGSSTSSSASSTSSHPGGRPTTAPSAAATPGAAATTALAGLEAHTHIDLHSAPPDVTTGLVE
HSYFERPQVASVRSVPRGCSGSMLETADGVPVNSRVSSKIQQLLNTLKRPKRPPLKEFFVDDFEELLEVQQPDPNQPKPEGSETSVLRGE
PLTAGVPRPPSLLATLQRWGTTQPKSPCLTALDTTGKAVYTLTYGKLWSRSLKLAYTLLNKLTSKNEPLLKPGDRLNWLSVDFNNWKDWE

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>22832_22832_7_DIP2A-PTGES3_DIP2A_chr21_47949096_ENST00000466639_PTGES3_chr12_57064148_ENST00000262033_length(transcript)=2554nt_BP=1220nt
GCTGTCCTGGCCGCGCCCCTGTCCCGCCGCCTCCCGCTCCTCGCCTGGCGGATGTAGGTTGTTGGCCTGAGGGGAGCTACGTAGCCGAGG
TTTGCGCTGCCGCCGCCAGGCCCGGTCCGGTTCCAGCCTCTGCCCGGACGCTAGCCGGCCTGGCCATGGCTGACCGCGGGTGCCCGCTGG
AGGCGGCGCCGCTGCCTGCCGAGGTGCGGGAGAGCCTGGCTGAGCTGGAGCTGGAGCTGTCGGAAGGTGACATCACTCAAAAAGGATATG
AAAAGAAAAGGGCAAAGCTGCTTGCACGTTATATACCGCTTATTCAAGGAATAGACCCATCTCTGCAAGCAGAGAATAGAATTCCTGGGC
CCTCACAAACCACGGCCGCTGCACCCAAGCAGCAGAAGTCTCGGCCCACCGCCTCGAGGGATGAGCGCTTCCGGTCAGATGTCCACACTG
AAGCCGTGCAAGCAGCTTTGGCCAAATACAAAGAGAGGAAGATGCCTATGCCTTCGAAGAGACGTTCTGTCCTTGTGCATTCGTCTGTGG
AAACCTACACCCCTCCAGACACGTCGTCTGCCTCAGAAGATGAGGGCTCTTTACGGCGACCCGGGCGACTCACCTCCACTCCGCTCCAGA
GCCATTCCAGCGTCGAGCCCTGGCTCGACCGGGTCATTCAGGGCTCGTCCACCTCATCCTCTGCATCCTCCACCTCATCTCACCCGGGAG
GGAGACCCACCACTGCTCCCAGTGCTGCAGCCACGCCGGGGGCCGCCGCTACCACTGCACTCGCAGGCCTCGAGGCCCACACCCACATAG
GTGTCCCTGTGAACAGCAGAGTGTCCTCCAAAATCCAGCAGCTTCTGAACACCCTGAAGAGGCCAAAGCGCCCTCCACTGAAGGAGTTCT
TTGTGGATGATTTTGAGGAATTGTTGGAAGTTCAGCAACCAGATCCAAATCAGCCAAAGCCTGAGGGAAGCGAGACGAGTGTGCTGAGAG
GGGAGCCTCTCACTGCAGGTGTCCCCCGACCGCCGTCGCTGTTGGCCACCTTGCAGCGCTGGGGCACAACACAGCCCAAATCCCCCTGTC
TGACTGCCTTGGATACAACTGGGAAAGCCGTCTACACTCTCACCTATGGTAAACTTTGGAGTCGGAGTTTAAAACTAGCTTATACTCTAC
TTAATAAACTGACAAGTAAGAATGAACCTCTACTTAAACCTGGAGACAGACTTAATTGGCTTAGTGTCGACTTCAATAATTGGAAAGACT
GGGAAGATGATTCAGATGAAGACATGTCTAATTTTGATCGTTTCTCTGAGATGATGAACAACATGGGTGGTGATGAGGATGTAGATTTAC
CAGAAGTAGATGGAGCAGATGATGATTCACAAGACAGTGATGATGAAAAAATGCCAGATCTGGAGTAAGGAATATTGTCATCACCTGGAT
TTTGAGAAAGAAAAATAACTTCTCTGCAAGATTTCATAATTGAGAGAATTCCTGAGTTGATAGCTCTAAAGGCAGATATGCTGTATTTGC
CTACTTTAACCCATTTTTCAACCTGTTTGTTTTTTAAAAGGCTTCACTAAGGGTTGATATGTACCATTGTATGGGGCAATTTTAAGTCAG
CTAAGGCAATAACCTTATGCATGAACATTTCCCAGACTTTCATGAAGCTGTTGAGGTCCTAGGCAATTAATGCAGCAGTTGCGATAAATA
AAAACATCTCACCTAAGTCTCCTTTTCTTCATAACATAGATACTGACATGATAGGAAGCTCTCAGCTTAGGGAAAGAGAATAAATTTTAG
ATTATAGAACATGGATTCAAAAGTGACTGGAACAAATTGGCTGACACCTTACTGGTAACCTGCTATTCTTCTGGTGTTATCCTTCAGGAT
TGTTCCACTAAAATTTATTTTTCAAAAAATTTACTTCACATTATTCTATGTAAGTGATGACTTGTCAGTGTTCCAGGTGTATCTTAGCTA
AAACTAGAGAATGCCCTAACTTAGATGGTTTTTGAAGCCTATACAATTGGTATTGTTTGACCCTTAAGCTTTTACATCTCTTAGCATGGA
GGACGAAGAAAGCTGTACATTGTTGCTTGAGAGTCTGTACATTTAGTCCAGATTTGTATTTGCACTGTCAGTATGGCAAATGAGTGAAAA
ATGTTTAATACACTATTGGATTTTTTATTTCCTTTTTTTGATTCAGCTTATACCCGGGCTGAAAACCTCAATTTATGTTCATGACAGTGG
GGATTTTTTTAAATGTCTACATTCTTTCTAATAAACTGTTGGAAGACTTCTTGGCTGTCCTTTTAAGTGTCTGGCTTACTGTAATTTTTA
TGTATTTACCATTTACTGGAATGGAGTTTATTTGAGGAAGAATTTGGGATTATTCCTCTGTTTGAAAAAAGAGGCTTGCTGTAATGTCAC
AGGAAACCTTTTAAAAGTGGATCTGTAATAGCATATTGTAGATGCACTTTGCAGCAGTTGGAAAAGAAAGTGTTGTGTGATTTGATTGAA

>22832_22832_7_DIP2A-PTGES3_DIP2A_chr21_47949096_ENST00000466639_PTGES3_chr12_57064148_ENST00000262033_length(amino acids)=457AA_BP=392
MADVGCWPEGSYVAEVCAAAARPGPVPASARTLAGLAMADRGCPLEAAPLPAEVRESLAELELELSEGDITQKGYEKKRAKLLARYIPLI
QGIDPSLQAENRIPGPSQTTAAAPKQQKSRPTASRDERFRSDVHTEAVQAALAKYKERKMPMPSKRRSVLVHSSVETYTPPDTSSASEDE
GSLRRPGRLTSTPLQSHSSVEPWLDRVIQGSSTSSSASSTSSHPGGRPTTAPSAAATPGAAATTALAGLEAHTHIGVPVNSRVSSKIQQL
LNTLKRPKRPPLKEFFVDDFEELLEVQQPDPNQPKPEGSETSVLRGEPLTAGVPRPPSLLATLQRWGTTQPKSPCLTALDTTGKAVYTLT
YGKLWSRSLKLAYTLLNKLTSKNEPLLKPGDRLNWLSVDFNNWKDWEDDSDEDMSNFDRFSEMMNNMGGDEDVDLPEVDGADDDSQDSDD

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Fusion Gene PPI Analysis for DIP2A-PTGES3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DIP2A-PTGES3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DIP2A-PTGES3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource