Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DIP2C-LARP4B (FusionGDB2 ID:22869)

Fusion Gene Summary for DIP2C-LARP4B

Fusion gene summary

Fusion gene information	Fusion gene name: DIP2C-LARP4B
	Fusion gene ID: 22869
		Hgene	Tgene
	Gene symbol	DIP2C	LARP4B
	Gene ID	22982	23185
	Gene name	disco interacting protein 2 homolog C	La ribonucleoprotein 4B
	Synonyms	KIAA0934	KIAA0217\|LARP5
	Cytomap	10p15.3	10p15.3
	Type of gene	protein-coding	protein-coding
	Description	disco-interacting protein 2 homolog CDIP2 disco-interacting protein 2 homolog CDIP2 homolog C	la-related protein 4BLa ribonucleoprotein domain family member 4BLa ribonucleoprotein domain family, member 5la-related protein 5
	Modification date	20200313	20200313
	UniProtAcc	Q9Y2E4	Q92615
	Ensembl transtripts involved in fusion gene	ENST00000280886, ENST00000381496, ENST00000540204,	ENST00000469487, ENST00000316157,
Fusion gene scores	* DoF score	25 X 15 X 14=5250	7 X 7 X 4=196
	# samples	27	7
	** MAII score	log2(27/5250*10)=-4.28128611039002 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DIP2C [Title/Abstract] AND LARP4B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DIP2C(735434)-LARP4B(910210), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across DIP2C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LARP4B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-BF-AAP2-01A	DIP2C	chr10	735434	-	LARP4B	chr10	910210	-

Top

Fusion Gene ORF analysis for DIP2C-LARP4B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000280886	ENST00000469487	DIP2C	chr10	735434	-	LARP4B	chr10	910210	-
In-frame	ENST00000280886	ENST00000316157	DIP2C	chr10	735434	-	LARP4B	chr10	910210	-
intron-3CDS	ENST00000381496	ENST00000316157	DIP2C	chr10	735434	-	LARP4B	chr10	910210	-
intron-3CDS	ENST00000540204	ENST00000316157	DIP2C	chr10	735434	-	LARP4B	chr10	910210	-
intron-intron	ENST00000381496	ENST00000469487	DIP2C	chr10	735434	-	LARP4B	chr10	910210	-
intron-intron	ENST00000540204	ENST00000469487	DIP2C	chr10	735434	-	LARP4B	chr10	910210	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000280886

DIP2C

chr10

735434

ENST00000316157

LARP4B

chr10

910210

5631

173

197

2248

683

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000280886	ENST00000316157	DIP2C	chr10	735434	-	LARP4B	chr10	910210	-	0.001244936	0.9987551

Top

Fusion Genomic Features for DIP2C-LARP4B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for DIP2C-LARP4B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:735434/chr10:910210)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DIP2C Q9Y2E4	LARP4B Q92615
	FUNCTION: Stimulates mRNA translation. {ECO:0000269\|PubMed:20573744}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

LARP4B

chr10:735434

chr10:910210

ENST00000316157

150_239

739.0

Domain

HTH La-type RNA-binding

Tgene

LARP4B

chr10:735434

chr10:910210

ENST00000316157

240_307

739.0

Domain

Note=RRM

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DIP2C

chr10:735434

chr10:910210

ENST00000280886

7_120

1557.0

Domain

DMAP1-binding

Top

Fusion Gene Sequence for DIP2C-LARP4B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>22869_22869_1_DIP2C-LARP4B_DIP2C_chr10_735434_ENST00000280886_LARP4B_chr10_910210_ENST00000316157_length(transcript)=5631nt_BP=173nt
CGGTGCGGTTCCGCCGGGCGCGAGGAGCCGCCGAGACCTCCGCCTGCGAACAAAGAGGAGGCCGTGCGGGGCGCGGCGCCCGCGGAGCAT
GGCGGACCGCAGCCTGGAGGGCATGGCGCTGCCCCTGGAGGTGCGGGCGCGCCTGGCCGAGCTGGAGCTGGAGCTGTCGGAAGGTACCAG
CAACTAAGGTTTCAGAGCTGAACCCTAATGCAGAAGTGTGGGGGGCTCCTGTGTTACATCTGGAAGCAAGCAGTGCTGCTGACGGTGTGA
GTGCTGCATGGGAGGAGGTGGCTGGCCACCACGCAGACCGTGGCCCGCAGGGATCGGATGCCAATGGTGATGGTGACCAGGGCCATGAGA
ATGCCGCATTGCCAGACCCGCAGGAGTCGGACCCAGCAGACATGAACGCTCTCGCTCTGGGTCCCTCAGAATATGACTCTCTGCCTGAAA
ATAGCGAGACAGGAGGAAATGAGTCTCAACCAGACAGCCAGGAAGACCCCCGAGAAGTACTTAAAAAAACATTGGAATTCTGCTTATCTA
GGGAGAACCTTGCTAGTGACATGTATCTTATATCACAGATGGATAGTGACCAGTATGTGCCAATCACAACGGTGGCTAACCTCGACCACA
TCAAGAAGCTCAGCACTGATGTGGACTTGATTGTGGAAGTGCTAAGATCTTTACCTTTAGTCCAAGTGGATGAAAAGGGAGAAAAAGTAA
GGCCAAATCAAAATCGCTGCATAGTAATATTGCGTGAAATATCTGAATCTACCCCCGTGGAAGAAGTAGAAGCACTATTTAAAGGAGATA
ATTTACCAAAATTTATAAACTGTGAATTTGCATATAATGATAATTGGTTTATTACATTTGAAACAGAAGCTGATGCACAACAGGCTTACA
AATACCTTCGAGAAGAAGTCAAAACTTTTCAAGGAAAACCAATTAAGGCACGGATAAAAGCAAAGGCAATAGCTATAAACACATTTTTGC
CAAAGAATGGATTTAGACCCCTGGACGTGAGCCTGTATGCCCAGCAGCGCTACGCGACGTCGTTCTACTTCCCTCCCATGTACAGCCCCC
AGCAGCAGTTCCCCCTGTACAGCCTGATCACTCCCCAGACGTGGTCAGCAACGCACAGCTATCTTGACCCACCCTTGGTAACTCCATTTC
CAAATACTGGATTTATAAATGGGTTTACGTCTCCAGCGTTCAAGCCTGCGGCGTCTCCTCTGACTTCTCTCAGACAGTATCCTCCTCGAA
GCAGGAATCCTAGTAAATCTCATCTGCGGCATGCGATTCCTAGTGCAGAGAGGGGACCTGGGTTATTAGAAAGTCCTTCAATATTTAACT
TCACTGCAGATCGATTAATTAATGGTGTCCGGAGTCCACAAACAAGGCAAGCAGGTCAAACTAGAACACGGATTCAAAACCCTTCAGCAT
ATGCCAAGAGAGAGGCTGGGCCTGGGCGTGTGGAGCCAGGCAGTCTCGAATCCTCTCCTGGTTTAGGGAGGGGAAGGAAGAATTCCTTTG
GCTACCGGAAGAAAAGGGAGGAGAAGTTTACAAGCAGCCAGACACAGTCTCCAACGCCACCAAAGCCTCCGTCGCCAAGCTTCGAGCTGG
GGCTGTCCAGCTTCCCTCCATTACCTGGAGCTGCCGGCAATTTGAAGACAGAGGACTTGTTTGAAAACAGGCTATCTAGCTTGATAATAG
GACCATCCAAAGAAAGGACCCTCAGTGCAGACGCAAGCGTGAACACCCTTCCTGTAGTGGTCTCCAGAGAGCCCTCGGTGCCGGCTTCTT
GTGCTGTATCAGCAACGTACGAGCGATCCCCCTCCCCAGCTCATTTACCCGATGATCCCAAGGTGGCGGAGAAACAGAGGGAAACCCACA
GTGTGGACAGACTTCCTTCCGCCCTCACTGCGACCGCGTGTAAATCGGTGCAGGTGAACGGAGCCGCCACGGAATTGCGAAAGCCCAGCT
ACGCAGAGATTTGTCAGAGAACGAGTAAAGAGCCTCCTTCTTCCCCATTGCAACCCCAAAAAGAACAAAAGCCAAACACTGTTGGTTGTG
GGAAGGAGGAAAAGAAGCTGGCAGAGCCCGCAGAGAGATACCGGGAGCCCCCAGCCCTCAAGTCCACACCTGGAGCCCCCAGAGACCAGA
GGCGGCCGGCGGGGGGCCGGCCCTCGCCCTCGGCCATGGGGAAGCGTCTCAGCCGAGAGCAGAGCACTCCCCCCAAGTCTCCTCAGTGAA
AACCGTACGTCTGGGAGGGGTCGCAGAGCGCTGTGTTAACCACAAACGAGACACTCTCCCACTCAGTGCGAGGGCGAGCCGCTGGTTAGG
AGCTTGCAGTGTCTGAGGCCTGTGGGATCCTCAAGTTGGTTTTCTTCTGTGAGTTGGATTCTCCCCCTCTTGAAAAAAAATCGATTTTTC
AGGATTTAATTAATACAAACCTTATTTTAGGTTGGTGCTTAACTGGAGGTGATGCATAAGTCTGATTTTTTTTTCCAAGATAGAAAAAGC
ATTTATCCTAACAAATTGGTATTTTTTATTAAGCCTCCATGTGGCTCTGAATGCAAGCTATATATAGTGAGTTTTTCTAAATTAAGGGAA
CTCTGCTTTTTTTTTTTTTTTTTAAGTAACTGGTCTGTAAGTGCATATCTCTAGAACGTCCCCGCAGATGAATGAGGGCCAGTGGCCTTG
GCAGAGGCAGGTGTGGCCTCGTAGAGGCAGTGCTGGCCGCGCCAGGGCATCAGTGCTGATGTGGGAGCTGTGCTTCCACCTAAGCCGTTG
GTAGGGGACTGTGGCATTTAAGAATGTAGAGAGCGCATCCTTTTTGATCTCCTGGGCGGAGTGAACCTGCAGGGGCCACCCCAGAAACCT
TGGTTCTGATGCACTGCAAGCAAGTAACCAGCTTCTCACTCCAGTTTCAAGTGGCTATTATGTAATATAAATTCAAAGCACATTGTGAAT
AGAACCTACATGAAAACATACACTTTGTTGCCCACTGACATGTTACCAGAAGTTGTACCATGATGTTGTTTTGACCCCTGTGAGCTGATG
GCCCCGGCCCTGCTCTGTGCACATTTCTGTCCGTGTTCCCCAGCACTCTGGTTGGAGAGAGTCCACATCTTCAGCTCCGTGTGGACATCT
CCCTGTACCTCTGCATCAGCACATGGATTTAAGAGTTATGTAATCGTGAGAGAATGGTGTTTGTGGTTTTTCCCCCTCTTTGGCTGGTGG
AGGATAAAGTTCCTGCTCTTTTACCTCCAAGACGAGGGCCTCATTGATTCACTTCCAGAAGTGCTGCACTTCTGAAGAACAAGGATGCAC
TAAAGTTAGCAAGTTTATAATAAAGTTAAATATAAATTATTTTGTTTTAAAATGCCTCAAATTTTTCTTTATTCTAAGCAGCAAACATTA
AAATAAGAATATTTCCTGCTAAATGTAACCATACACTTTATTCCACAAAATGTTATTTAACAAGACTGAGGGTTTTTTTTAAGAAAAAAT
TATTTCCATCCAATATTTAAAGACTTGAATTTTATTTAAACTTGAAAATGACTTTGCCTTAACTTTTGTATAAGACAGCTTAGAGTCCAT
GGAGCCCGGCCCTGGGTTGGCGTGAGTGGGTCAGAGTTACTCAGTTACTGCGTGGATCTCCTGTCGCTAGTTTTACTGAGTAAGCATACT
GTAGTACAAGAGCTAGTAGTAGTTTTTGTAATATACCTTAAAGATCTTCAACAGTTGATCTTTTTTCAGAATGTTGGAAAATCCTGTAAA
TGCAAATAGTCAATACTGTATTAAATACGTGCACTTGGAGTGTGCTTCGCTTGTACAGTTGTAAATAATCAGAACATATGAAAAAGGTAC
CCTACAGAGAAAATTCTGATACAGATTATTGATATATTATAAATGTTGCTGTTGAGCGGGATGTAGATAAACTAAATGTTGTGGTTTGAA
TATTATTTTGATTTGTTGAGATTTTCTTTTTTCTCTTACATCGGTGTGTTGAACTGATTCTGCCTCTTTGCTGCAAAAGGGAATTGGAAA
GTCTTATTAAAAGCCTCCAGATGTTTTCATACTCTTTTAAAATGTATGTAAATGCATACTAATCATATCTAATGTGAAAGAGTTTTAAAG
TATATAGAGAGCAAAAACTGGCAGGATCGTAAGTGAAGGTGACTAGTAATCTAATTTAAATCACCTGCAGCTAAGCATGATTGACCCTGC
CAGAGGAAAACATGCCTATTTGACCATTTCCTTTAAAGCAGTTGCCATTATTCAAATACAGAGAAATAGCCACAGGGCTAGTGTTTTTCA
AATGCATTTTAAAGAACATGGGGATTTTTTTTTGTAGTTGTCAGTTCACTGACCAAAAAAAAAAAAAAAATCAGAAATAATTGATCTGTG
AAACCCAAACTCTCAATACTCAGAAAGCTGGGAGGCAACCTCGAGGCCTGGGCCTACGAGCTGCATCTTCGCTACGGAAGGGCCAGGGCG
CCATCAGCCATTCCCAAAACACAAGGCCTGCCCGTCCGCCAGTGAGTCCTTGGTTTTTAATAATGAGAAGTCCTTTCCCCCAAGGTGTGA
GCATTGCAGCGCAGTGTGTGTGTGTGGTTAGAGCCAGCTTAGTCCTTCACTTTGTCGACCGAAGTGGGAGCTCAACAGCTGCATGAGGAG
GGCAGCGCGTGCATTAGCCAGTCGCCACTGGAGGGCTCTGCTGCCCTCCGGTCAATACACTGTAGTTACTGCCTAGCCAGCAGCAGTCTT
CTGCATCAAGAACTGAAACGTTGCTCGGAGGTGATTTTTATAGCATCCTTTTTAATTAAAGGTGAAATACAGATTGCTATATAATGTCTG
AAAAAACCTGATACTACTTCAAGAGTTTCTGCTCAGAAGAAAATGAGAGTTATCATAATAGGAAGCTGTGGCGGTCCATGCCAACTGTGC
TGTGTCACATACAGCGATGAGAGTGGCTTTCATACTTTTTTTTTTTTTAAGTTAACACCCTCCTTTACCCCCAGCAGTATCTCAGGTTAT
AGAATCAGAGATGCAGCAGTGACAAATGGCATTTTAACTTGTAAAATCGTGTGATGATGCTTATCATTTTGAAATAGAAGAATAAAAACC
TGGTCCCGTTTCACCAGACATGAATTTCAAGTGGAGTCGTCGTTCTCTGAGAGTGAGTGTCTTGACATTTTCACCCAGGCCCTCCTGTCA
TCACATCACCGGCTGTCACTGGCGGGTGGCCGTAAACGTCCTGCGTTGCTATATTAGGATCTCTGCAGTTCAGGCTTCAAAACCAGTTCA
GTGTATCCGGGCGACGGGTAGTGGTGGTGCATGCCTGTCTGTGTGCCCCGCTGGCGAGCTGTAGTTGCGGCTTGCGTGCCTCGCGGCCCA
CTACAGGGCTGCAGACAATCGAGGCGAGGGCGCTGGCCGCCAGCAGCTCACAGCGCGGGGGTCATGTGGTCGCTCCTCGAGGGTTTCGTT
TTTGTTCTGCTTCATTAAGACTGGAATCAAGCTTACATGTAAACTATTGGTAATTTAAGTTTCCTTTTGTGTCATTCAGTGTAAAACTGT

>22869_22869_1_DIP2C-LARP4B_DIP2C_chr10_735434_ENST00000280886_LARP4B_chr10_910210_ENST00000316157_length(amino acids)=683AA_BP=
MNPNAEVWGAPVLHLEASSAADGVSAAWEEVAGHHADRGPQGSDANGDGDQGHENAALPDPQESDPADMNALALGPSEYDSLPENSETGG
NESQPDSQEDPREVLKKTLEFCLSRENLASDMYLISQMDSDQYVPITTVANLDHIKKLSTDVDLIVEVLRSLPLVQVDEKGEKVRPNQNR
CIVILREISESTPVEEVEALFKGDNLPKFINCEFAYNDNWFITFETEADAQQAYKYLREEVKTFQGKPIKARIKAKAIAINTFLPKNGFR
PLDVSLYAQQRYATSFYFPPMYSPQQQFPLYSLITPQTWSATHSYLDPPLVTPFPNTGFINGFTSPAFKPAASPLTSLRQYPPRSRNPSK
SHLRHAIPSAERGPGLLESPSIFNFTADRLINGVRSPQTRQAGQTRTRIQNPSAYAKREAGPGRVEPGSLESSPGLGRGRKNSFGYRKKR
EEKFTSSQTQSPTPPKPPSPSFELGLSSFPPLPGAAGNLKTEDLFENRLSSLIIGPSKERTLSADASVNTLPVVVSREPSVPASCAVSAT
YERSPSPAHLPDDPKVAEKQRETHSVDRLPSALTATACKSVQVNGAATELRKPSYAEICQRTSKEPPSSPLQPQKEQKPNTVGCGKEEKK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DIP2C-LARP4B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for DIP2C-LARP4B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for DIP2C-LARP4B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source