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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DIS3L2-INPP5D (FusionGDB2 ID:22905)

Fusion Gene Summary for DIS3L2-INPP5D

check button Fusion gene summary
Fusion gene informationFusion gene name: DIS3L2-INPP5D
Fusion gene ID: 22905
HgeneTgene
Gene symbol

DIS3L2

INPP5D

Gene ID

129563

3635

Gene nameDIS3 like 3'-5' exoribonuclease 2inositol polyphosphate-5-phosphatase D
SynonymsFAM6A|PRLMNS|hDIS3L2SHIP|SHIP-1|SHIP1|SIP-145|hp51CN|p150Ship
Cytomap

2q37.1

2q37.1

Type of geneprotein-codingprotein-coding
DescriptionDIS3-like exonuclease 2DIS3 mitotic control homolog-like 2family with sequence similarity 6, member Aphosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1SH2 domain-containing inositol 5'-phosphatase 1inositol polyphosphate-5-phosphatase, 145kDinositol polyphosphate-5-phosphatase, 145kDaphosphatidylinositol 4,5-bisphosphate 5-phosphatasesignaling
Modification date2020031320200313
UniProtAcc

Q8IYB7

Q92835

Ensembl transtripts involved in fusion geneENST00000273009, ENST00000325385, 
ENST00000409307, ENST00000360410, 
ENST00000409401, ENST00000470087, 
ENST00000474278, ENST00000538935, 
ENST00000359570, ENST00000450745, 
ENST00000455936, 
Fusion gene scores* DoF score27 X 9 X 12=29168 X 10 X 5=400
# samples 2510
** MAII scorelog2(25/2916*10)=-3.54399071966485
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/400*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DIS3L2 [Title/Abstract] AND INPP5D [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDIS3L2(233103355)-INPP5D(234054804), # samples:1
Anticipated loss of major functional domain due to fusion event.DIS3L2-INPP5D seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDIS3L2

GO:0010587

miRNA catabolic process

24141620


check buttonFusion gene breakpoints across DIS3L2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across INPP5D (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A4OPDIS3L2chr2

233103355

+INPP5Dchr2

234054804

+


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Fusion Gene ORF analysis for DIS3L2-INPP5D

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000273009ENST00000474278DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
5CDS-intronENST00000325385ENST00000474278DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
5CDS-intronENST00000409307ENST00000474278DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
Frame-shiftENST00000273009ENST00000538935DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
Frame-shiftENST00000325385ENST00000538935DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
Frame-shiftENST00000409307ENST00000538935DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
In-frameENST00000273009ENST00000359570DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
In-frameENST00000273009ENST00000450745DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
In-frameENST00000273009ENST00000455936DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
In-frameENST00000325385ENST00000359570DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
In-frameENST00000325385ENST00000450745DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
In-frameENST00000325385ENST00000455936DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
In-frameENST00000409307ENST00000359570DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
In-frameENST00000409307ENST00000450745DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
In-frameENST00000409307ENST00000455936DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
intron-3CDSENST00000360410ENST00000359570DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
intron-3CDSENST00000360410ENST00000450745DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
intron-3CDSENST00000360410ENST00000455936DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
intron-3CDSENST00000360410ENST00000538935DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
intron-3CDSENST00000409401ENST00000359570DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
intron-3CDSENST00000409401ENST00000450745DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
intron-3CDSENST00000409401ENST00000455936DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
intron-3CDSENST00000409401ENST00000538935DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
intron-3CDSENST00000470087ENST00000359570DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
intron-3CDSENST00000470087ENST00000450745DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
intron-3CDSENST00000470087ENST00000455936DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
intron-3CDSENST00000470087ENST00000538935DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
intron-intronENST00000360410ENST00000474278DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
intron-intronENST00000409401ENST00000474278DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+
intron-intronENST00000470087ENST00000474278DIS3L2chr2

233103355

+INPP5Dchr2

234054804

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000273009DIS3L2chr2233103355+ENST00000359570INPP5Dchr2234054804+5942193157847471389
ENST00000273009DIS3L2chr2233103355+ENST00000450745INPP5Dchr2234054804+5942193157847471389
ENST00000273009DIS3L2chr2233103355+ENST00000455936INPP5Dchr2234054804+5946193157847501390
ENST00000325385DIS3L2chr2233103355+ENST00000359570INPP5Dchr2234054804+5604159324044091389
ENST00000325385DIS3L2chr2233103355+ENST00000450745INPP5Dchr2234054804+5604159324044091389
ENST00000325385DIS3L2chr2233103355+ENST00000455936INPP5Dchr2234054804+5608159324044121390
ENST00000409307DIS3L2chr2233103355+ENST00000359570INPP5Dchr2234054804+53281317041331377
ENST00000409307DIS3L2chr2233103355+ENST00000450745INPP5Dchr2234054804+53281317041331377
ENST00000409307DIS3L2chr2233103355+ENST00000455936INPP5Dchr2234054804+53321317041361378

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000273009ENST00000359570DIS3L2chr2233103355+INPP5Dchr2234054804+0.0039187010.9960813
ENST00000273009ENST00000450745DIS3L2chr2233103355+INPP5Dchr2234054804+0.0039187010.9960813
ENST00000273009ENST00000455936DIS3L2chr2233103355+INPP5Dchr2234054804+0.0041204130.99587953
ENST00000325385ENST00000359570DIS3L2chr2233103355+INPP5Dchr2234054804+0.002613780.9973863
ENST00000325385ENST00000450745DIS3L2chr2233103355+INPP5Dchr2234054804+0.002613780.9973863
ENST00000325385ENST00000455936DIS3L2chr2233103355+INPP5Dchr2234054804+0.0027533050.99724674
ENST00000409307ENST00000359570DIS3L2chr2233103355+INPP5Dchr2234054804+0.0017790360.998221
ENST00000409307ENST00000450745DIS3L2chr2233103355+INPP5Dchr2234054804+0.0017790360.998221
ENST00000409307ENST00000455936DIS3L2chr2233103355+INPP5Dchr2234054804+0.0018828150.9981172

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Fusion Genomic Features for DIS3L2-INPP5D


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DIS3L2chr2233103355+INPP5Dchr2234054804+0.298122260.7018777
DIS3L2chr2233103355+INPP5Dchr2234054804+0.298122260.7018777

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DIS3L2-INPP5D


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:233103355/chr2:234054804)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DIS3L2

Q8IYB7

INPP5D

Q92835

FUNCTION: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. {ECO:0000255|HAMAP-Rule:MF_03045, ECO:0000269|PubMed:23756462, ECO:0000269|PubMed:24141620}.FUNCTION: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:8723348, PubMed:10764818, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:9108392, PubMed:10764818, PubMed:8769125). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:9108392}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneINPP5Dchr2:233103355chr2:234054804ENST00000359570729920_11482391178.0Compositional biasNote=Pro-rich
TgeneINPP5Dchr2:233103355chr2:234054804ENST000003595707291019_10222391178.0MotifNote=NPXY motif 2
TgeneINPP5Dchr2:233103355chr2:234054804ENST000003595707291040_10512391178.0MotifNote=SH3-binding 3
TgeneINPP5Dchr2:233103355chr2:234054804ENST00000359570729912_9152391178.0MotifNote=NPXY motif 1
TgeneINPP5Dchr2:233103355chr2:234054804ENST00000359570729969_9742391178.0MotifNote=SH3-binding 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneINPP5Dchr2:233103355chr2:234054804ENST000003595707295_1012391178.0DomainSH2
TgeneINPP5Dchr2:233103355chr2:234054804ENST00000359570729124_1292391178.0MotifNote=SH3-binding 1


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Fusion Gene Sequence for DIS3L2-INPP5D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22905_22905_1_DIS3L2-INPP5D_DIS3L2_chr2_233103355_ENST00000273009_INPP5D_chr2_234054804_ENST00000359570_length(transcript)=5942nt_BP=1931nt
ATGCGGGGGTTGTCCATCTCTGTATCCCCAGTGCCAGCACTGCACCTCGCCCCAAGCAGTTGTCCAATAAATGAGCAGTGAGTAAATGAA
AGAATGAGCAAAGCCTTGTAACAGGAAAGGGGCCGGCGGCGTCTGCCGTGCAAGACCTGGCCCAGTGGAGCAGAGCCTGGAGGTTCAGGA
GCCGGGTCTGGAAGGCTCCTTCCGGTGGAAGAGGGGCCCGGAGCCAGCCGGCGCCTGGCACAAGGCGTCTCAGAGGCCGCCCACTGGGAG
CCAACCGTTGCAGCCAGTTGTCCCCGCGAGCGAGGCCGGAGAAGGCGCGGCGGCCCCTGGCCTGGCCATTTCGCCCTTGTCGCAGCTGAA
CCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCACCGTCGCTCTCTAGAACGCCGCG
CCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAAACGCGAATGACAACAGAGCTGC
TCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAGCCAATAATGAGCCATCCTGACT
ACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCTTCGCCAGGTGACAAAA
AGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCAGAAGGCTTGAAGAGAG
GAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGTGATCGAGACATTTTTA
TTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCATTGGAAGGTAGTTAAAC
CAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTCCCGCAACAGTCCCTGA
AAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGCATCACACAAAATGTGC
TGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACAAAAGATGAGACCACCT
GCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAGAAAAAACATTCTCGAG
CAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCCTCAGACCACCGAGTGC
CTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTGTTCATCTGCCGCATTG
TGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAGCCTGAAACAGAAGGAA
TACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCATGGACAATTCCACCAG
AGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGAGACCTCGATGATGCCCTCTCCT
GCAAGCCACTCGCTGACGGCAACTTCAAAGTGGGAGTTCACATTGCTGACGTGAGTTACTTTGTTCCGGAGGGATCTGATCTGGATAAAG
TGGCTGCCGAGAGGGCTACAAGCGTCTACTTGGTTCAAAAGGTTCCTGGTGAGGCCAATCCCATCAACATGGTGTCCAAGCTCAGCCAAC
TGACAAGCCTGTTGTCGTCCATTGAAGACAAGGTCAAGGCCTTGCTGCACGAGGGTCCTGAGTCTCCGCACCGGCCCTCCCTTATCCCTC
CAGTCACCTTTGAGGTGAAGGCAGAGTCTCTGGGGATTCCTCAGAAAATGCAGCTCAAAGTCGACGTTGAGTCTGGGAAACTGATCATTA
AGAAGTCCAAGGATGGTTCTGAGGACAAGTTCTACAGCCACAAGAAAATCCTGCAGCTCATTAAGTCACAGAAATTTCTGAATAAGTTGG
TGATCTTGGTGGAAACAGAGAAGGAGAAGATCCTGCGGAAGGAATATGTTTTTGCTGACTCCAAAAAGAGAGAAGGCTTCTGCCAGCTCC
TGCAGCAGATGAAGAACAAGCACTCAGAGCAGCCGGAGCCCGACATGATCACCATCTTCATCGGCACCTGGAACATGGGTAACGCCCCCC
CTCCCAAGAAGATCACGTCCTGGTTTCTCTCCAAGGGGCAGGGAAAGACGCGGGACGACTCTGCGGACTACATCCCCCATGACATTTACG
TGATCGGCACCCAAGAGGACCCCCTGAGTGAGAAGGAGTGGCTGGAGATCCTCAAACACTCCCTGCAAGAAATCACCAGTGTGACTTTTA
AAACAGTCGCCATCCACACGCTCTGGAACATCCGCATCGTGGTGCTGGCCAAGCCTGAGCACGAGAACCGGATCAGCCACATCTGTACTG
ACAACGTGAAGACAGGCATTGCAAACACACTGGGGAACAAGGGAGCCGTGGGGGTGTCGTTCATGTTCAATGGAACCTCCTTAGGGTTCG
TCAACAGCCACTTGACTTCAGGAAGTGAAAAGAAACTCAGGCGAAACCAAAACTATATGAACATTCTCCGGTTCCTGGCCCTGGGCGACA
AGAAGCTGAGTCCCTTTAACATCACTCACCGCTTCACGCACCTCTTCTGGTTTGGGGATCTTAACTACCGTGTGGATCTGCCTACCTGGG
AGGCAGAAACCATCATCCAGAAAATCAAGCAGCAGCAGTACGCAGACCTCCTGTCCCACGACCAGCTGCTCACAGAGAGGAGGGAGCAGA
AGGTCTTCCTACACTTCGAGGAGGAAGAAATCACGTTTGCCCCAACCTACCGTTTTGAGAGACTGACTCGGGACAAATACGCCTACACCA
AGCAGAAAGCGACAGGGATGAAGTACAACTTGCCTTCCTGGTGTGACCGAGTCCTCTGGAAGTCTTATCCCCTGGTGCACGTGGTGTGTC
AGTCTTATGGCAGTACCAGCGACATCATGACGAGTGACCACAGCCCTGTCTTTGCCACATTTGAGGCAGGAGTCACTTCCCAGTTTGTCT
CCAAGAACGGTCCCGGGACTGTTGACAGCCAAGGACAGATTGAGTTTCTCAGGTGCTATGCCACATTGAAGACCAAGTCCCAGACCAAAT
TCTACCTGGAGTTCCACTCGAGCTGCTTGGAGAGTTTTGTCAAGAGTCAGGAAGGAGAAAATGAAGAAGGAAGTGAGGGGGAGCTGGTGG
TGAAGTTTGGTGAGACTCTTCCAAAGCTGAAGCCCATTATCTCTGACCCTGAGTACCTGCTAGACCAGCACATCCTCATCAGCATCAAGT
CCTCTGACAGCGACGAATCCTATGGCGAGGGCTGCATTGCCCTTCGGTTAGAGGCCACAGAAACGCAGCTGCCCATCTACACGCCTCTCA
CCCACCATGGGGAGTTGACAGGCCACTTCCAGGGGGAGATCAAGCTGCAGACCTCTCAGGGCAAGACGAGGGAGAAGCTCTATGACTTTG
TGAAGACGGAGCGTGATGAATCCAGTGGGCCAAAGACCCTGAAGAGCCTCACCAGCCACGACCCCATGAAGCAGTGGGAAGTCACTAGCA
GGGCCCCTCCGTGCAGTGGCTCCAGCATCACTGAAATCATCAACCCCAACTACATGGGAGTGGGGCCCTTTGGGCCACCAATGCCCCTGC
ACGTGAAGCAGACCTTGTCCCCTGACCAGCAGCCCACAGCCTGGAGCTACGACCAGCCGCCCAAGGACTCCCCGCTGGGGCCCTGCAGGG
GAGAAAGTCCTCCGACACCTCCCGGCCAGCCGCCCATATCACCCAAGAAGTTTTTACCCTCAACAGCAAACCGGGGTCTCCCTCCCAGGA
CACAGGAGTCAAGGCCCAGTGACCTGGGGAAGAACGCAGGGGACACGCTGCCTCAGGAGGACCTGCCGCTGACGAAGCCCGAGATGTTTG
AGAACCCCCTGTATGGGTCCCTGAGTTCCTTCCCTAAGCCTGCTCCCAGGAAGGACCAGGAATCCCCCAAAATGCCGCGGAAGGAACCCC
CGCCCTGCCCGGAACCCGGCATCTTGTCGCCCAGCATCGTGCTCACCAAAGCCCAGGAGGCTGATCGCGGCGAGGGGCCCGGCAAGCAGG
TGCCCGCGCCCCGGCTGCGCTCCTTCACGTGCTCATCCTCTGCCGAGGGCAGGGCGGCCGGCGGGGACAAGAGCCAAGGGAAGCCCAAGA
CCCCGGTCAGCTCCCAGGCCCCGGTGCCGGCCAAGAGGCCCATCAAGCCTTCCAGATCGGAAATCAACCAGCAGACCCCGCCCACCCCGA
CGCCGCGGCCGCCGCTGCCAGTCAAGAGCCCGGCGGTGCTGCACCTCCAGCACTCCAAGGGCCGCGACTACCGCGACAACACCGAGCTCC
CGCATCACGGCAAGCACCGGCCGGAGGAGGGGCCACCAGGGCCTCTAGGCAGGACTGCCATGCAGTGAAGCCCTCAGTGAGCTGCCACTG
AGTCGGGAGCCCAGAGGAACGGCGTGAAGCCACTGGACCCTCTCCCGGGACCTCCTGCTGGCTCCTCCTGCCCAGCTTCCTATGCAAGGC
TTTGTGTTTTCAGGAAAGGGCCTAGCTTCTGTGTGGCCCACAGAGTTCACTGCCTGTGAGACTTAGCACCAAGTGCTGAGGCTGGAAGAA
AAACGCACACCAGACGGGCAACAAACAGTCTGGGTCCCCAGCTCGCTCTTGGTACTTGGGACCCCAGTGCCTCGTTGAGGGCGCCATTCT
GAAGAAAGGAACTGCAGCGCCGATTTGAGGGTGGAGATATAGATAATAATAATATTAATAATAATAATGGCCACATGGATCGAACACTCA
TGATGTGCCAAGTGCTGTGCTAAGTGCTTTACGAACATTCGTCATATCAGGATGACCTCGAGAGCTGAGGCTCTAGCCACCTAAAACCAC
GTGCCCAAACCCACCAGTTTAAAACGGTGTGTGTTCGGAGGGGTGAAAGCATTAAGAAGCCCAGTGCCCTCCTGGAGTGAGACAAGGGCT
CGGCCTTAAGGAGCTGAAGAGTCTGGGTAGCTTGTTTAGGGTACAAGAAGCCTGTTCTGTCCAGCTTCAGTGACACAAGCTGCTTTAGCT
AAAGTCCCGCGGGTTCCGGCATGGCTAGGCTGAGAGCAGGGATCTACCTGGCTTCTCAGTTCTTTGGTTGGAAGGAGCAGGAAATCAGCT
CCTATTCTCCAGTGGAGAGATCTGGCCTCAGCTTGGGCTAGAGATGCCAAGGCCTGTGCCAGGTTCCCTGTGCCCTCCTCGAGGTGGGCA
GCCATCACCAGCCACAGTTAAGCCAAGCCCCCCAACATGTATTCCATCGTGCTGGTAGAAGAGTCTTTGCTGTTGCTCCCGAAAGCCGTG
CTCTCCAGCCTGGCTGCCAGGGAGGGTGGGCCTCTTGGTTCCAGGCTCTTGAAATAGTGCAGCCTTTTCTTCCTATCTCTGTGGCTTTCA
GCTCTGCTTCCTTGGTTATTAGGAGAATAGATGGGTGATGTCTTTCCTTATGTTGCTTTTTCAACATAGCAGAATTAATGTAGGGAGCTA
AATCCAGTGGTGTGTGTGAATGCAGAAGGGAATGCACCCCACATTCCCATGATGGAAGTCTGCGTAACCAATAAATTGTGCCTTTCTCAC

>22905_22905_1_DIS3L2-INPP5D_DIS3L2_chr2_233103355_ENST00000273009_INPP5D_chr2_234054804_ENST00000359570_length(amino acids)=1389AA_BP=451
MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK
KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA
QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN
SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS
SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQ
KVPGEANPINMVSKLSQLTSLLSSIEDKVKALLHEGPESPHRPSLIPPVTFEVKAESLGIPQKMQLKVDVESGKLIIKKSKDGSEDKFYS
HKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFLSKG
QGKTRDDSADYIPHDIYVIGTQEDPLSEKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGN
KGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQKIKQQQ
YADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSD
HSPVFATFEAGVTSQFVSKNGPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKFGETLPKLKPI
ISDPEYLLDQHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQTSQGKTREKLYDFVKTERDESSGPKT
LKSLTSHDPMKQWEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPI
SPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPSI
VLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKSPAV

--------------------------------------------------------------
>22905_22905_2_DIS3L2-INPP5D_DIS3L2_chr2_233103355_ENST00000273009_INPP5D_chr2_234054804_ENST00000450745_length(transcript)=5942nt_BP=1931nt
ATGCGGGGGTTGTCCATCTCTGTATCCCCAGTGCCAGCACTGCACCTCGCCCCAAGCAGTTGTCCAATAAATGAGCAGTGAGTAAATGAA
AGAATGAGCAAAGCCTTGTAACAGGAAAGGGGCCGGCGGCGTCTGCCGTGCAAGACCTGGCCCAGTGGAGCAGAGCCTGGAGGTTCAGGA
GCCGGGTCTGGAAGGCTCCTTCCGGTGGAAGAGGGGCCCGGAGCCAGCCGGCGCCTGGCACAAGGCGTCTCAGAGGCCGCCCACTGGGAG
CCAACCGTTGCAGCCAGTTGTCCCCGCGAGCGAGGCCGGAGAAGGCGCGGCGGCCCCTGGCCTGGCCATTTCGCCCTTGTCGCAGCTGAA
CCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCACCGTCGCTCTCTAGAACGCCGCG
CCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAAACGCGAATGACAACAGAGCTGC
TCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAGCCAATAATGAGCCATCCTGACT
ACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCTTCGCCAGGTGACAAAA
AGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCAGAAGGCTTGAAGAGAG
GAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGTGATCGAGACATTTTTA
TTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCATTGGAAGGTAGTTAAAC
CAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTCCCGCAACAGTCCCTGA
AAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGCATCACACAAAATGTGC
TGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACAAAAGATGAGACCACCT
GCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAGAAAAAACATTCTCGAG
CAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCCTCAGACCACCGAGTGC
CTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTGTTCATCTGCCGCATTG
TGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAGCCTGAAACAGAAGGAA
TACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCATGGACAATTCCACCAG
AGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGAGACCTCGATGATGCCCTCTCCT
GCAAGCCACTCGCTGACGGCAACTTCAAAGTGGGAGTTCACATTGCTGACGTGAGTTACTTTGTTCCGGAGGGATCTGATCTGGATAAAG
TGGCTGCCGAGAGGGCTACAAGCGTCTACTTGGTTCAAAAGGTTCCTGGTGAGGCCAATCCCATCAACATGGTGTCCAAGCTCAGCCAAC
TGACAAGCCTGTTGTCGTCCATTGAAGACAAGGTCAAGGCCTTGCTGCACGAGGGTCCTGAGTCTCCGCACCGGCCCTCCCTTATCCCTC
CAGTCACCTTTGAGGTGAAGGCAGAGTCTCTGGGGATTCCTCAGAAAATGCAGCTCAAAGTCGACGTTGAGTCTGGGAAACTGATCATTA
AGAAGTCCAAGGATGGTTCTGAGGACAAGTTCTACAGCCACAAGAAAATCCTGCAGCTCATTAAGTCACAGAAATTTCTGAATAAGTTGG
TGATCTTGGTGGAAACAGAGAAGGAGAAGATCCTGCGGAAGGAATATGTTTTTGCTGACTCCAAAAAGAGAGAAGGCTTCTGCCAGCTCC
TGCAGCAGATGAAGAACAAGCACTCAGAGCAGCCGGAGCCCGACATGATCACCATCTTCATCGGCACCTGGAACATGGGTAACGCCCCCC
CTCCCAAGAAGATCACGTCCTGGTTTCTCTCCAAGGGGCAGGGAAAGACGCGGGACGACTCTGCGGACTACATCCCCCATGACATTTACG
TGATCGGCACCCAAGAGGACCCCCTGAGTGAGAAGGAGTGGCTGGAGATCCTCAAACACTCCCTGCAAGAAATCACCAGTGTGACTTTTA
AAACAGTCGCCATCCACACGCTCTGGAACATCCGCATCGTGGTGCTGGCCAAGCCTGAGCACGAGAACCGGATCAGCCACATCTGTACTG
ACAACGTGAAGACAGGCATTGCAAACACACTGGGGAACAAGGGAGCCGTGGGGGTGTCGTTCATGTTCAATGGAACCTCCTTAGGGTTCG
TCAACAGCCACTTGACTTCAGGAAGTGAAAAGAAACTCAGGCGAAACCAAAACTATATGAACATTCTCCGGTTCCTGGCCCTGGGCGACA
AGAAGCTGAGTCCCTTTAACATCACTCACCGCTTCACGCACCTCTTCTGGTTTGGGGATCTTAACTACCGTGTGGATCTGCCTACCTGGG
AGGCAGAAACCATCATCCAGAAAATCAAGCAGCAGCAGTACGCAGACCTCCTGTCCCACGACCAGCTGCTCACAGAGAGGAGGGAGCAGA
AGGTCTTCCTACACTTCGAGGAGGAAGAAATCACGTTTGCCCCAACCTACCGTTTTGAGAGACTGACTCGGGACAAATACGCCTACACCA
AGCAGAAAGCGACAGGGATGAAGTACAACTTGCCTTCCTGGTGTGACCGAGTCCTCTGGAAGTCTTATCCCCTGGTGCACGTGGTGTGTC
AGTCTTATGGCAGTACCAGCGACATCATGACGAGTGACCACAGCCCTGTCTTTGCCACATTTGAGGCAGGAGTCACTTCCCAGTTTGTCT
CCAAGAACGGTCCCGGGACTGTTGACAGCCAAGGACAGATTGAGTTTCTCAGGTGCTATGCCACATTGAAGACCAAGTCCCAGACCAAAT
TCTACCTGGAGTTCCACTCGAGCTGCTTGGAGAGTTTTGTCAAGAGTCAGGAAGGAGAAAATGAAGAAGGAAGTGAGGGGGAGCTGGTGG
TGAAGTTTGGTGAGACTCTTCCAAAGCTGAAGCCCATTATCTCTGACCCTGAGTACCTGCTAGACCAGCACATCCTCATCAGCATCAAGT
CCTCTGACAGCGACGAATCCTATGGCGAGGGCTGCATTGCCCTTCGGTTAGAGGCCACAGAAACGCAGCTGCCCATCTACACGCCTCTCA
CCCACCATGGGGAGTTGACAGGCCACTTCCAGGGGGAGATCAAGCTGCAGACCTCTCAGGGCAAGACGAGGGAGAAGCTCTATGACTTTG
TGAAGACGGAGCGTGATGAATCCAGTGGGCCAAAGACCCTGAAGAGCCTCACCAGCCACGACCCCATGAAGCAGTGGGAAGTCACTAGCA
GGGCCCCTCCGTGCAGTGGCTCCAGCATCACTGAAATCATCAACCCCAACTACATGGGAGTGGGGCCCTTTGGGCCACCAATGCCCCTGC
ACGTGAAGCAGACCTTGTCCCCTGACCAGCAGCCCACAGCCTGGAGCTACGACCAGCCGCCCAAGGACTCCCCGCTGGGGCCCTGCAGGG
GAGAAAGTCCTCCGACACCTCCCGGCCAGCCGCCCATATCACCCAAGAAGTTTTTACCCTCAACAGCAAACCGGGGTCTCCCTCCCAGGA
CACAGGAGTCAAGGCCCAGTGACCTGGGGAAGAACGCAGGGGACACGCTGCCTCAGGAGGACCTGCCGCTGACGAAGCCCGAGATGTTTG
AGAACCCCCTGTATGGGTCCCTGAGTTCCTTCCCTAAGCCTGCTCCCAGGAAGGACCAGGAATCCCCCAAAATGCCGCGGAAGGAACCCC
CGCCCTGCCCGGAACCCGGCATCTTGTCGCCCAGCATCGTGCTCACCAAAGCCCAGGAGGCTGATCGCGGCGAGGGGCCCGGCAAGCAGG
TGCCCGCGCCCCGGCTGCGCTCCTTCACGTGCTCATCCTCTGCCGAGGGCAGGGCGGCCGGCGGGGACAAGAGCCAAGGGAAGCCCAAGA
CCCCGGTCAGCTCCCAGGCCCCGGTGCCGGCCAAGAGGCCCATCAAGCCTTCCAGATCGGAAATCAACCAGCAGACCCCGCCCACCCCGA
CGCCGCGGCCGCCGCTGCCAGTCAAGAGCCCGGCGGTGCTGCACCTCCAGCACTCCAAGGGCCGCGACTACCGCGACAACACCGAGCTCC
CGCATCACGGCAAGCACCGGCCGGAGGAGGGGCCACCAGGGCCTCTAGGCAGGACTGCCATGCAGTGAAGCCCTCAGTGAGCTGCCACTG
AGTCGGGAGCCCAGAGGAACGGCGTGAAGCCACTGGACCCTCTCCCGGGACCTCCTGCTGGCTCCTCCTGCCCAGCTTCCTATGCAAGGC
TTTGTGTTTTCAGGAAAGGGCCTAGCTTCTGTGTGGCCCACAGAGTTCACTGCCTGTGAGACTTAGCACCAAGTGCTGAGGCTGGAAGAA
AAACGCACACCAGACGGGCAACAAACAGTCTGGGTCCCCAGCTCGCTCTTGGTACTTGGGACCCCAGTGCCTCGTTGAGGGCGCCATTCT
GAAGAAAGGAACTGCAGCGCCGATTTGAGGGTGGAGATATAGATAATAATAATATTAATAATAATAATGGCCACATGGATCGAACACTCA
TGATGTGCCAAGTGCTGTGCTAAGTGCTTTACGAACATTCGTCATATCAGGATGACCTCGAGAGCTGAGGCTCTAGCCACCTAAAACCAC
GTGCCCAAACCCACCAGTTTAAAACGGTGTGTGTTCGGAGGGGTGAAAGCATTAAGAAGCCCAGTGCCCTCCTGGAGTGAGACAAGGGCT
CGGCCTTAAGGAGCTGAAGAGTCTGGGTAGCTTGTTTAGGGTACAAGAAGCCTGTTCTGTCCAGCTTCAGTGACACAAGCTGCTTTAGCT
AAAGTCCCGCGGGTTCCGGCATGGCTAGGCTGAGAGCAGGGATCTACCTGGCTTCTCAGTTCTTTGGTTGGAAGGAGCAGGAAATCAGCT
CCTATTCTCCAGTGGAGAGATCTGGCCTCAGCTTGGGCTAGAGATGCCAAGGCCTGTGCCAGGTTCCCTGTGCCCTCCTCGAGGTGGGCA
GCCATCACCAGCCACAGTTAAGCCAAGCCCCCCAACATGTATTCCATCGTGCTGGTAGAAGAGTCTTTGCTGTTGCTCCCGAAAGCCGTG
CTCTCCAGCCTGGCTGCCAGGGAGGGTGGGCCTCTTGGTTCCAGGCTCTTGAAATAGTGCAGCCTTTTCTTCCTATCTCTGTGGCTTTCA
GCTCTGCTTCCTTGGTTATTAGGAGAATAGATGGGTGATGTCTTTCCTTATGTTGCTTTTTCAACATAGCAGAATTAATGTAGGGAGCTA
AATCCAGTGGTGTGTGTGAATGCAGAAGGGAATGCACCCCACATTCCCATGATGGAAGTCTGCGTAACCAATAAATTGTGCCTTTCTCAC

>22905_22905_2_DIS3L2-INPP5D_DIS3L2_chr2_233103355_ENST00000273009_INPP5D_chr2_234054804_ENST00000450745_length(amino acids)=1389AA_BP=451
MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK
KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA
QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN
SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS
SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQ
KVPGEANPINMVSKLSQLTSLLSSIEDKVKALLHEGPESPHRPSLIPPVTFEVKAESLGIPQKMQLKVDVESGKLIIKKSKDGSEDKFYS
HKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFLSKG
QGKTRDDSADYIPHDIYVIGTQEDPLSEKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGN
KGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQKIKQQQ
YADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSD
HSPVFATFEAGVTSQFVSKNGPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKFGETLPKLKPI
ISDPEYLLDQHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQTSQGKTREKLYDFVKTERDESSGPKT
LKSLTSHDPMKQWEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPI
SPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPSI
VLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKSPAV

--------------------------------------------------------------
>22905_22905_3_DIS3L2-INPP5D_DIS3L2_chr2_233103355_ENST00000273009_INPP5D_chr2_234054804_ENST00000455936_length(transcript)=5946nt_BP=1931nt
ATGCGGGGGTTGTCCATCTCTGTATCCCCAGTGCCAGCACTGCACCTCGCCCCAAGCAGTTGTCCAATAAATGAGCAGTGAGTAAATGAA
AGAATGAGCAAAGCCTTGTAACAGGAAAGGGGCCGGCGGCGTCTGCCGTGCAAGACCTGGCCCAGTGGAGCAGAGCCTGGAGGTTCAGGA
GCCGGGTCTGGAAGGCTCCTTCCGGTGGAAGAGGGGCCCGGAGCCAGCCGGCGCCTGGCACAAGGCGTCTCAGAGGCCGCCCACTGGGAG
CCAACCGTTGCAGCCAGTTGTCCCCGCGAGCGAGGCCGGAGAAGGCGCGGCGGCCCCTGGCCTGGCCATTTCGCCCTTGTCGCAGCTGAA
CCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCACCGTCGCTCTCTAGAACGCCGCG
CCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAAACGCGAATGACAACAGAGCTGC
TCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAGCCAATAATGAGCCATCCTGACT
ACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCTTCGCCAGGTGACAAAA
AGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCAGAAGGCTTGAAGAGAG
GAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGTGATCGAGACATTTTTA
TTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCATTGGAAGGTAGTTAAAC
CAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTCCCGCAACAGTCCCTGA
AAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGCATCACACAAAATGTGC
TGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACAAAAGATGAGACCACCT
GCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAGAAAAAACATTCTCGAG
CAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCCTCAGACCACCGAGTGC
CTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTGTTCATCTGCCGCATTG
TGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAGCCTGAAACAGAAGGAA
TACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCATGGACAATTCCACCAG
AGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGAGACCTCGATGATGCCCTCTCCT
GCAAGCCACTCGCTGACGGCAACTTCAAAGTGGGAGTTCACATTGCTGACGTGAGTTACTTTGTTCCGGAGGGATCTGATCTGGATAAAG
TGGCTGCCGAGAGGGCTACAAGCGTCTACTTGGTTCAAAAGCAGGTTCCTGGTGAGGCCAATCCCATCAACATGGTGTCCAAGCTCAGCC
AACTGACAAGCCTGTTGTCGTCCATTGAAGACAAGGTCAAGGCCTTGCTGCACGAGGGTCCTGAGTCTCCGCACCGGCCCTCCCTTATCC
CTCCAGTCACCTTTGAGGTGAAGGCAGAGTCTCTGGGGATTCCTCAGAAAATGCAGCTCAAAGTCGACGTTGAGTCTGGGAAACTGATCA
TTAAGAAGTCCAAGGATGGTTCTGAGGACAAGTTCTACAGCCACAAGAAAATCCTGCAGCTCATTAAGTCACAGAAATTTCTGAATAAGT
TGGTGATCTTGGTGGAAACAGAGAAGGAGAAGATCCTGCGGAAGGAATATGTTTTTGCTGACTCCAAAAAGAGAGAAGGCTTCTGCCAGC
TCCTGCAGCAGATGAAGAACAAGCACTCAGAGCAGCCGGAGCCCGACATGATCACCATCTTCATCGGCACCTGGAACATGGGTAACGCCC
CCCCTCCCAAGAAGATCACGTCCTGGTTTCTCTCCAAGGGGCAGGGAAAGACGCGGGACGACTCTGCGGACTACATCCCCCATGACATTT
ACGTGATCGGCACCCAAGAGGACCCCCTGAGTGAGAAGGAGTGGCTGGAGATCCTCAAACACTCCCTGCAAGAAATCACCAGTGTGACTT
TTAAAACAGTCGCCATCCACACGCTCTGGAACATCCGCATCGTGGTGCTGGCCAAGCCTGAGCACGAGAACCGGATCAGCCACATCTGTA
CTGACAACGTGAAGACAGGCATTGCAAACACACTGGGGAACAAGGGAGCCGTGGGGGTGTCGTTCATGTTCAATGGAACCTCCTTAGGGT
TCGTCAACAGCCACTTGACTTCAGGAAGTGAAAAGAAACTCAGGCGAAACCAAAACTATATGAACATTCTCCGGTTCCTGGCCCTGGGCG
ACAAGAAGCTGAGTCCCTTTAACATCACTCACCGCTTCACGCACCTCTTCTGGTTTGGGGATCTTAACTACCGTGTGGATCTGCCTACCT
GGGAGGCAGAAACCATCATCCAGAAAATCAAGCAGCAGCAGTACGCAGACCTCCTGTCCCACGACCAGCTGCTCACAGAGAGGAGGGAGC
AGAAGGTCTTCCTACACTTCGAGGAGGAAGAAATCACGTTTGCCCCAACCTACCGTTTTGAGAGACTGACTCGGGACAAATACGCCTACA
CCAAGCAGAAAGCGACAGGGATGAAGTACAACTTGCCTTCCTGGTGTGACCGAGTCCTCTGGAAGTCTTATCCCCTGGTGCACGTGGTGT
GTCAGTCTTATGGCAGTACCAGCGACATCATGACGAGTGACCACAGCCCTGTCTTTGCCACATTTGAGGCAGGAGTCACTTCCCAGTTTG
TCTCCAAGAACGGTCCCGGGACTGTTGACAGCCAAGGACAGATTGAGTTTCTCAGGTGCTATGCCACATTGAAGACCAAGTCCCAGACCA
AATTCTACCTGGAGTTCCACTCGAGCTGCTTGGAGAGTTTTGTCAAGAGTCAGGAAGGAGAAAATGAAGAAGGAAGTGAGGGGGAGCTGG
TGGTGAAGTTTGGTGAGACTCTTCCAAAGCTGAAGCCCATTATCTCTGACCCTGAGTACCTGCTAGACCAGCACATCCTCATCAGCATCA
AGTCCTCTGACAGCGACGAATCCTATGGCGAGGGCTGCATTGCCCTTCGGTTAGAGGCCACAGAAACGCAGCTGCCCATCTACACGCCTC
TCACCCACCATGGGGAGTTGACAGGCCACTTCCAGGGGGAGATCAAGCTGCAGACCTCTCAGGGCAAGACGAGGGAGAAGCTCTATGACT
TTGTGAAGACGGAGCGTGATGAATCCAGTGGGCCAAAGACCCTGAAGAGCCTCACCAGCCACGACCCCATGAAGCAGTGGGAAGTCACTA
GCAGGGCCCCTCCGTGCAGTGGCTCCAGCATCACTGAAATCATCAACCCCAACTACATGGGAGTGGGGCCCTTTGGGCCACCAATGCCCC
TGCACGTGAAGCAGACCTTGTCCCCTGACCAGCAGCCCACAGCCTGGAGCTACGACCAGCCGCCCAAGGACTCCCCGCTGGGGCCCTGCA
GGGGAGAAAGTCCTCCGACACCTCCCGGCCAGCCGCCCATATCACCCAAGAAGTTTTTACCCTCAACAGCAAACCGGGGTCTCCCTCCCA
GGACACAGGAGTCAAGGCCCAGTGACCTGGGGAAGAACGCAGGGGACACGCTGCCTCAGGAGGACCTGCCGCTGACGAAGCCCGAGATGT
TTGAGAACCCCCTGTATGGGTCCCTGAGTTCCTTCCCTAAGCCTGCTCCCAGGAAGGACCAGGAATCCCCCAAAATGCCGCGGAAGGAAC
CCCCGCCCTGCCCGGAACCCGGCATCTTGTCGCCCAGCATCGTGCTCACCAAAGCCCAGGAGGCTGATCGCGGCGAGGGGCCCGGCAAGC
AGGTGCCCGCGCCCCGGCTGCGCTCCTTCACGTGCTCATCCTCTGCCGAGGGCAGGGCGGCCGGCGGGGACAAGAGCCAAGGGAAGCCCA
AGACCCCGGTCAGCTCCCAGGCCCCGGTGCCGGCCAAGAGGCCCATCAAGCCTTCCAGATCGGAAATCAACCAGCAGACCCCGCCCACCC
CGACGCCGCGGCCGCCGCTGCCAGTCAAGAGCCCGGCGGTGCTGCACCTCCAGCACTCCAAGGGCCGCGACTACCGCGACAACACCGAGC
TCCCGCATCACGGCAAGCACCGGCCGGAGGAGGGGCCACCAGGGCCTCTAGGCAGGACTGCCATGCAGTGAAGCCCTCAGTGAGCTGCCA
CTGAGTCGGGAGCCCAGAGGAACGGCGTGAAGCCACTGGACCCTCTCCCGGGACCTCCTGCTGGCTCCTCCTGCCCAGCTTCCTATGCAA
GGCTTTGTGTTTTCAGGAAAGGGCCTAGCTTCTGTGTGGCCCACAGAGTTCACTGCCTGTGAGACTTAGCACCAAGTGCTGAGGCTGGAA
GAAAAACGCACACCAGACGGGCAACAAACAGTCTGGGTCCCCAGCTCGCTCTTGGTACTTGGGACCCCAGTGCCTCGTTGAGGGCGCCAT
TCTGAAGAAAGGAACTGCAGCGCCGATTTGAGGGTGGAGATATAGATAATAATAATATTAATAATAATAATGGCCACATGGATCGAACAC
TCATGATGTGCCAAGTGCTGTGCTAAGTGCTTTACGAACATTCGTCATATCAGGATGACCTCGAGAGCTGAGGCTCTAGCCACCTAAAAC
CACGTGCCCAAACCCACCAGTTTAAAACGGTGTGTGTTCGGAGGGGTGAAAGCATTAAGAAGCCCAGTGCCCTCCTGGAGTGAGACAAGG
GCTCGGCCTTAAGGAGCTGAAGAGTCTGGGTAGCTTGTTTAGGGTACAAGAAGCCTGTTCTGTCCAGCTTCAGTGACACAAGCTGCTTTA
GCTAAAGTCCCGCGGGTTCCGGCATGGCTAGGCTGAGAGCAGGGATCTACCTGGCTTCTCAGTTCTTTGGTTGGAAGGAGCAGGAAATCA
GCTCCTATTCTCCAGTGGAGAGATCTGGCCTCAGCTTGGGCTAGAGATGCCAAGGCCTGTGCCAGGTTCCCTGTGCCCTCCTCGAGGTGG
GCAGCCATCACCAGCCACAGTTAAGCCAAGCCCCCCAACATGTATTCCATCGTGCTGGTAGAAGAGTCTTTGCTGTTGCTCCCGAAAGCC
GTGCTCTCCAGCCTGGCTGCCAGGGAGGGTGGGCCTCTTGGTTCCAGGCTCTTGAAATAGTGCAGCCTTTTCTTCCTATCTCTGTGGCTT
TCAGCTCTGCTTCCTTGGTTATTAGGAGAATAGATGGGTGATGTCTTTCCTTATGTTGCTTTTTCAACATAGCAGAATTAATGTAGGGAG
CTAAATCCAGTGGTGTGTGTGAATGCAGAAGGGAATGCACCCCACATTCCCATGATGGAAGTCTGCGTAACCAATAAATTGTGCCTTTCT

>22905_22905_3_DIS3L2-INPP5D_DIS3L2_chr2_233103355_ENST00000273009_INPP5D_chr2_234054804_ENST00000455936_length(amino acids)=1390AA_BP=451
MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK
KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA
QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN
SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS
SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQ
KQVPGEANPINMVSKLSQLTSLLSSIEDKVKALLHEGPESPHRPSLIPPVTFEVKAESLGIPQKMQLKVDVESGKLIIKKSKDGSEDKFY
SHKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFLSK
GQGKTRDDSADYIPHDIYVIGTQEDPLSEKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLG
NKGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQKIKQQ
QYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTS
DHSPVFATFEAGVTSQFVSKNGPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKFGETLPKLKP
IISDPEYLLDQHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQTSQGKTREKLYDFVKTERDESSGPK
TLKSLTSHDPMKQWEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPP
ISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPS
IVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKSPA

--------------------------------------------------------------
>22905_22905_4_DIS3L2-INPP5D_DIS3L2_chr2_233103355_ENST00000325385_INPP5D_chr2_234054804_ENST00000359570_length(transcript)=5604nt_BP=1593nt
TTTCGCCCTTGTCGCAGCTGAACCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCAC
CGTCGCTCTCTAGAACGCCGCGCCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAA
ACGCGAATGACAACAGAGCTGCTCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAG
CCAATAATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATT
GGTGCTTCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGAT
GTTTCAGAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCG
GATGGTGATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAG
GAGCATTGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACAC
CATCTCCCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGA
CATGGCATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCG
GTTACAAAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATC
TTGGAGAAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTT
TCTCCCTCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAAC
ACACTGTTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAA
ATTGAGCCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGC
CTGCCATGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGA
GACCTCGATGATGCCCTCTCCTGCAAGCCACTCGCTGACGGCAACTTCAAAGTGGGAGTTCACATTGCTGACGTGAGTTACTTTGTTCCG
GAGGGATCTGATCTGGATAAAGTGGCTGCCGAGAGGGCTACAAGCGTCTACTTGGTTCAAAAGGTTCCTGGTGAGGCCAATCCCATCAAC
ATGGTGTCCAAGCTCAGCCAACTGACAAGCCTGTTGTCGTCCATTGAAGACAAGGTCAAGGCCTTGCTGCACGAGGGTCCTGAGTCTCCG
CACCGGCCCTCCCTTATCCCTCCAGTCACCTTTGAGGTGAAGGCAGAGTCTCTGGGGATTCCTCAGAAAATGCAGCTCAAAGTCGACGTT
GAGTCTGGGAAACTGATCATTAAGAAGTCCAAGGATGGTTCTGAGGACAAGTTCTACAGCCACAAGAAAATCCTGCAGCTCATTAAGTCA
CAGAAATTTCTGAATAAGTTGGTGATCTTGGTGGAAACAGAGAAGGAGAAGATCCTGCGGAAGGAATATGTTTTTGCTGACTCCAAAAAG
AGAGAAGGCTTCTGCCAGCTCCTGCAGCAGATGAAGAACAAGCACTCAGAGCAGCCGGAGCCCGACATGATCACCATCTTCATCGGCACC
TGGAACATGGGTAACGCCCCCCCTCCCAAGAAGATCACGTCCTGGTTTCTCTCCAAGGGGCAGGGAAAGACGCGGGACGACTCTGCGGAC
TACATCCCCCATGACATTTACGTGATCGGCACCCAAGAGGACCCCCTGAGTGAGAAGGAGTGGCTGGAGATCCTCAAACACTCCCTGCAA
GAAATCACCAGTGTGACTTTTAAAACAGTCGCCATCCACACGCTCTGGAACATCCGCATCGTGGTGCTGGCCAAGCCTGAGCACGAGAAC
CGGATCAGCCACATCTGTACTGACAACGTGAAGACAGGCATTGCAAACACACTGGGGAACAAGGGAGCCGTGGGGGTGTCGTTCATGTTC
AATGGAACCTCCTTAGGGTTCGTCAACAGCCACTTGACTTCAGGAAGTGAAAAGAAACTCAGGCGAAACCAAAACTATATGAACATTCTC
CGGTTCCTGGCCCTGGGCGACAAGAAGCTGAGTCCCTTTAACATCACTCACCGCTTCACGCACCTCTTCTGGTTTGGGGATCTTAACTAC
CGTGTGGATCTGCCTACCTGGGAGGCAGAAACCATCATCCAGAAAATCAAGCAGCAGCAGTACGCAGACCTCCTGTCCCACGACCAGCTG
CTCACAGAGAGGAGGGAGCAGAAGGTCTTCCTACACTTCGAGGAGGAAGAAATCACGTTTGCCCCAACCTACCGTTTTGAGAGACTGACT
CGGGACAAATACGCCTACACCAAGCAGAAAGCGACAGGGATGAAGTACAACTTGCCTTCCTGGTGTGACCGAGTCCTCTGGAAGTCTTAT
CCCCTGGTGCACGTGGTGTGTCAGTCTTATGGCAGTACCAGCGACATCATGACGAGTGACCACAGCCCTGTCTTTGCCACATTTGAGGCA
GGAGTCACTTCCCAGTTTGTCTCCAAGAACGGTCCCGGGACTGTTGACAGCCAAGGACAGATTGAGTTTCTCAGGTGCTATGCCACATTG
AAGACCAAGTCCCAGACCAAATTCTACCTGGAGTTCCACTCGAGCTGCTTGGAGAGTTTTGTCAAGAGTCAGGAAGGAGAAAATGAAGAA
GGAAGTGAGGGGGAGCTGGTGGTGAAGTTTGGTGAGACTCTTCCAAAGCTGAAGCCCATTATCTCTGACCCTGAGTACCTGCTAGACCAG
CACATCCTCATCAGCATCAAGTCCTCTGACAGCGACGAATCCTATGGCGAGGGCTGCATTGCCCTTCGGTTAGAGGCCACAGAAACGCAG
CTGCCCATCTACACGCCTCTCACCCACCATGGGGAGTTGACAGGCCACTTCCAGGGGGAGATCAAGCTGCAGACCTCTCAGGGCAAGACG
AGGGAGAAGCTCTATGACTTTGTGAAGACGGAGCGTGATGAATCCAGTGGGCCAAAGACCCTGAAGAGCCTCACCAGCCACGACCCCATG
AAGCAGTGGGAAGTCACTAGCAGGGCCCCTCCGTGCAGTGGCTCCAGCATCACTGAAATCATCAACCCCAACTACATGGGAGTGGGGCCC
TTTGGGCCACCAATGCCCCTGCACGTGAAGCAGACCTTGTCCCCTGACCAGCAGCCCACAGCCTGGAGCTACGACCAGCCGCCCAAGGAC
TCCCCGCTGGGGCCCTGCAGGGGAGAAAGTCCTCCGACACCTCCCGGCCAGCCGCCCATATCACCCAAGAAGTTTTTACCCTCAACAGCA
AACCGGGGTCTCCCTCCCAGGACACAGGAGTCAAGGCCCAGTGACCTGGGGAAGAACGCAGGGGACACGCTGCCTCAGGAGGACCTGCCG
CTGACGAAGCCCGAGATGTTTGAGAACCCCCTGTATGGGTCCCTGAGTTCCTTCCCTAAGCCTGCTCCCAGGAAGGACCAGGAATCCCCC
AAAATGCCGCGGAAGGAACCCCCGCCCTGCCCGGAACCCGGCATCTTGTCGCCCAGCATCGTGCTCACCAAAGCCCAGGAGGCTGATCGC
GGCGAGGGGCCCGGCAAGCAGGTGCCCGCGCCCCGGCTGCGCTCCTTCACGTGCTCATCCTCTGCCGAGGGCAGGGCGGCCGGCGGGGAC
AAGAGCCAAGGGAAGCCCAAGACCCCGGTCAGCTCCCAGGCCCCGGTGCCGGCCAAGAGGCCCATCAAGCCTTCCAGATCGGAAATCAAC
CAGCAGACCCCGCCCACCCCGACGCCGCGGCCGCCGCTGCCAGTCAAGAGCCCGGCGGTGCTGCACCTCCAGCACTCCAAGGGCCGCGAC
TACCGCGACAACACCGAGCTCCCGCATCACGGCAAGCACCGGCCGGAGGAGGGGCCACCAGGGCCTCTAGGCAGGACTGCCATGCAGTGA
AGCCCTCAGTGAGCTGCCACTGAGTCGGGAGCCCAGAGGAACGGCGTGAAGCCACTGGACCCTCTCCCGGGACCTCCTGCTGGCTCCTCC
TGCCCAGCTTCCTATGCAAGGCTTTGTGTTTTCAGGAAAGGGCCTAGCTTCTGTGTGGCCCACAGAGTTCACTGCCTGTGAGACTTAGCA
CCAAGTGCTGAGGCTGGAAGAAAAACGCACACCAGACGGGCAACAAACAGTCTGGGTCCCCAGCTCGCTCTTGGTACTTGGGACCCCAGT
GCCTCGTTGAGGGCGCCATTCTGAAGAAAGGAACTGCAGCGCCGATTTGAGGGTGGAGATATAGATAATAATAATATTAATAATAATAAT
GGCCACATGGATCGAACACTCATGATGTGCCAAGTGCTGTGCTAAGTGCTTTACGAACATTCGTCATATCAGGATGACCTCGAGAGCTGA
GGCTCTAGCCACCTAAAACCACGTGCCCAAACCCACCAGTTTAAAACGGTGTGTGTTCGGAGGGGTGAAAGCATTAAGAAGCCCAGTGCC
CTCCTGGAGTGAGACAAGGGCTCGGCCTTAAGGAGCTGAAGAGTCTGGGTAGCTTGTTTAGGGTACAAGAAGCCTGTTCTGTCCAGCTTC
AGTGACACAAGCTGCTTTAGCTAAAGTCCCGCGGGTTCCGGCATGGCTAGGCTGAGAGCAGGGATCTACCTGGCTTCTCAGTTCTTTGGT
TGGAAGGAGCAGGAAATCAGCTCCTATTCTCCAGTGGAGAGATCTGGCCTCAGCTTGGGCTAGAGATGCCAAGGCCTGTGCCAGGTTCCC
TGTGCCCTCCTCGAGGTGGGCAGCCATCACCAGCCACAGTTAAGCCAAGCCCCCCAACATGTATTCCATCGTGCTGGTAGAAGAGTCTTT
GCTGTTGCTCCCGAAAGCCGTGCTCTCCAGCCTGGCTGCCAGGGAGGGTGGGCCTCTTGGTTCCAGGCTCTTGAAATAGTGCAGCCTTTT
CTTCCTATCTCTGTGGCTTTCAGCTCTGCTTCCTTGGTTATTAGGAGAATAGATGGGTGATGTCTTTCCTTATGTTGCTTTTTCAACATA
GCAGAATTAATGTAGGGAGCTAAATCCAGTGGTGTGTGTGAATGCAGAAGGGAATGCACCCCACATTCCCATGATGGAAGTCTGCGTAAC

>22905_22905_4_DIS3L2-INPP5D_DIS3L2_chr2_233103355_ENST00000325385_INPP5D_chr2_234054804_ENST00000359570_length(amino acids)=1389AA_BP=451
MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK
KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA
QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN
SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS
SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQ
KVPGEANPINMVSKLSQLTSLLSSIEDKVKALLHEGPESPHRPSLIPPVTFEVKAESLGIPQKMQLKVDVESGKLIIKKSKDGSEDKFYS
HKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFLSKG
QGKTRDDSADYIPHDIYVIGTQEDPLSEKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGN
KGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQKIKQQQ
YADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSD
HSPVFATFEAGVTSQFVSKNGPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKFGETLPKLKPI
ISDPEYLLDQHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQTSQGKTREKLYDFVKTERDESSGPKT
LKSLTSHDPMKQWEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPI
SPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPSI
VLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKSPAV

--------------------------------------------------------------
>22905_22905_5_DIS3L2-INPP5D_DIS3L2_chr2_233103355_ENST00000325385_INPP5D_chr2_234054804_ENST00000450745_length(transcript)=5604nt_BP=1593nt
TTTCGCCCTTGTCGCAGCTGAACCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCAC
CGTCGCTCTCTAGAACGCCGCGCCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAA
ACGCGAATGACAACAGAGCTGCTCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAG
CCAATAATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATT
GGTGCTTCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGAT
GTTTCAGAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCG
GATGGTGATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAG
GAGCATTGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACAC
CATCTCCCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGA
CATGGCATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCG
GTTACAAAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATC
TTGGAGAAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTT
TCTCCCTCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAAC
ACACTGTTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAA
ATTGAGCCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGC
CTGCCATGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGA
GACCTCGATGATGCCCTCTCCTGCAAGCCACTCGCTGACGGCAACTTCAAAGTGGGAGTTCACATTGCTGACGTGAGTTACTTTGTTCCG
GAGGGATCTGATCTGGATAAAGTGGCTGCCGAGAGGGCTACAAGCGTCTACTTGGTTCAAAAGGTTCCTGGTGAGGCCAATCCCATCAAC
ATGGTGTCCAAGCTCAGCCAACTGACAAGCCTGTTGTCGTCCATTGAAGACAAGGTCAAGGCCTTGCTGCACGAGGGTCCTGAGTCTCCG
CACCGGCCCTCCCTTATCCCTCCAGTCACCTTTGAGGTGAAGGCAGAGTCTCTGGGGATTCCTCAGAAAATGCAGCTCAAAGTCGACGTT
GAGTCTGGGAAACTGATCATTAAGAAGTCCAAGGATGGTTCTGAGGACAAGTTCTACAGCCACAAGAAAATCCTGCAGCTCATTAAGTCA
CAGAAATTTCTGAATAAGTTGGTGATCTTGGTGGAAACAGAGAAGGAGAAGATCCTGCGGAAGGAATATGTTTTTGCTGACTCCAAAAAG
AGAGAAGGCTTCTGCCAGCTCCTGCAGCAGATGAAGAACAAGCACTCAGAGCAGCCGGAGCCCGACATGATCACCATCTTCATCGGCACC
TGGAACATGGGTAACGCCCCCCCTCCCAAGAAGATCACGTCCTGGTTTCTCTCCAAGGGGCAGGGAAAGACGCGGGACGACTCTGCGGAC
TACATCCCCCATGACATTTACGTGATCGGCACCCAAGAGGACCCCCTGAGTGAGAAGGAGTGGCTGGAGATCCTCAAACACTCCCTGCAA
GAAATCACCAGTGTGACTTTTAAAACAGTCGCCATCCACACGCTCTGGAACATCCGCATCGTGGTGCTGGCCAAGCCTGAGCACGAGAAC
CGGATCAGCCACATCTGTACTGACAACGTGAAGACAGGCATTGCAAACACACTGGGGAACAAGGGAGCCGTGGGGGTGTCGTTCATGTTC
AATGGAACCTCCTTAGGGTTCGTCAACAGCCACTTGACTTCAGGAAGTGAAAAGAAACTCAGGCGAAACCAAAACTATATGAACATTCTC
CGGTTCCTGGCCCTGGGCGACAAGAAGCTGAGTCCCTTTAACATCACTCACCGCTTCACGCACCTCTTCTGGTTTGGGGATCTTAACTAC
CGTGTGGATCTGCCTACCTGGGAGGCAGAAACCATCATCCAGAAAATCAAGCAGCAGCAGTACGCAGACCTCCTGTCCCACGACCAGCTG
CTCACAGAGAGGAGGGAGCAGAAGGTCTTCCTACACTTCGAGGAGGAAGAAATCACGTTTGCCCCAACCTACCGTTTTGAGAGACTGACT
CGGGACAAATACGCCTACACCAAGCAGAAAGCGACAGGGATGAAGTACAACTTGCCTTCCTGGTGTGACCGAGTCCTCTGGAAGTCTTAT
CCCCTGGTGCACGTGGTGTGTCAGTCTTATGGCAGTACCAGCGACATCATGACGAGTGACCACAGCCCTGTCTTTGCCACATTTGAGGCA
GGAGTCACTTCCCAGTTTGTCTCCAAGAACGGTCCCGGGACTGTTGACAGCCAAGGACAGATTGAGTTTCTCAGGTGCTATGCCACATTG
AAGACCAAGTCCCAGACCAAATTCTACCTGGAGTTCCACTCGAGCTGCTTGGAGAGTTTTGTCAAGAGTCAGGAAGGAGAAAATGAAGAA
GGAAGTGAGGGGGAGCTGGTGGTGAAGTTTGGTGAGACTCTTCCAAAGCTGAAGCCCATTATCTCTGACCCTGAGTACCTGCTAGACCAG
CACATCCTCATCAGCATCAAGTCCTCTGACAGCGACGAATCCTATGGCGAGGGCTGCATTGCCCTTCGGTTAGAGGCCACAGAAACGCAG
CTGCCCATCTACACGCCTCTCACCCACCATGGGGAGTTGACAGGCCACTTCCAGGGGGAGATCAAGCTGCAGACCTCTCAGGGCAAGACG
AGGGAGAAGCTCTATGACTTTGTGAAGACGGAGCGTGATGAATCCAGTGGGCCAAAGACCCTGAAGAGCCTCACCAGCCACGACCCCATG
AAGCAGTGGGAAGTCACTAGCAGGGCCCCTCCGTGCAGTGGCTCCAGCATCACTGAAATCATCAACCCCAACTACATGGGAGTGGGGCCC
TTTGGGCCACCAATGCCCCTGCACGTGAAGCAGACCTTGTCCCCTGACCAGCAGCCCACAGCCTGGAGCTACGACCAGCCGCCCAAGGAC
TCCCCGCTGGGGCCCTGCAGGGGAGAAAGTCCTCCGACACCTCCCGGCCAGCCGCCCATATCACCCAAGAAGTTTTTACCCTCAACAGCA
AACCGGGGTCTCCCTCCCAGGACACAGGAGTCAAGGCCCAGTGACCTGGGGAAGAACGCAGGGGACACGCTGCCTCAGGAGGACCTGCCG
CTGACGAAGCCCGAGATGTTTGAGAACCCCCTGTATGGGTCCCTGAGTTCCTTCCCTAAGCCTGCTCCCAGGAAGGACCAGGAATCCCCC
AAAATGCCGCGGAAGGAACCCCCGCCCTGCCCGGAACCCGGCATCTTGTCGCCCAGCATCGTGCTCACCAAAGCCCAGGAGGCTGATCGC
GGCGAGGGGCCCGGCAAGCAGGTGCCCGCGCCCCGGCTGCGCTCCTTCACGTGCTCATCCTCTGCCGAGGGCAGGGCGGCCGGCGGGGAC
AAGAGCCAAGGGAAGCCCAAGACCCCGGTCAGCTCCCAGGCCCCGGTGCCGGCCAAGAGGCCCATCAAGCCTTCCAGATCGGAAATCAAC
CAGCAGACCCCGCCCACCCCGACGCCGCGGCCGCCGCTGCCAGTCAAGAGCCCGGCGGTGCTGCACCTCCAGCACTCCAAGGGCCGCGAC
TACCGCGACAACACCGAGCTCCCGCATCACGGCAAGCACCGGCCGGAGGAGGGGCCACCAGGGCCTCTAGGCAGGACTGCCATGCAGTGA
AGCCCTCAGTGAGCTGCCACTGAGTCGGGAGCCCAGAGGAACGGCGTGAAGCCACTGGACCCTCTCCCGGGACCTCCTGCTGGCTCCTCC
TGCCCAGCTTCCTATGCAAGGCTTTGTGTTTTCAGGAAAGGGCCTAGCTTCTGTGTGGCCCACAGAGTTCACTGCCTGTGAGACTTAGCA
CCAAGTGCTGAGGCTGGAAGAAAAACGCACACCAGACGGGCAACAAACAGTCTGGGTCCCCAGCTCGCTCTTGGTACTTGGGACCCCAGT
GCCTCGTTGAGGGCGCCATTCTGAAGAAAGGAACTGCAGCGCCGATTTGAGGGTGGAGATATAGATAATAATAATATTAATAATAATAAT
GGCCACATGGATCGAACACTCATGATGTGCCAAGTGCTGTGCTAAGTGCTTTACGAACATTCGTCATATCAGGATGACCTCGAGAGCTGA
GGCTCTAGCCACCTAAAACCACGTGCCCAAACCCACCAGTTTAAAACGGTGTGTGTTCGGAGGGGTGAAAGCATTAAGAAGCCCAGTGCC
CTCCTGGAGTGAGACAAGGGCTCGGCCTTAAGGAGCTGAAGAGTCTGGGTAGCTTGTTTAGGGTACAAGAAGCCTGTTCTGTCCAGCTTC
AGTGACACAAGCTGCTTTAGCTAAAGTCCCGCGGGTTCCGGCATGGCTAGGCTGAGAGCAGGGATCTACCTGGCTTCTCAGTTCTTTGGT
TGGAAGGAGCAGGAAATCAGCTCCTATTCTCCAGTGGAGAGATCTGGCCTCAGCTTGGGCTAGAGATGCCAAGGCCTGTGCCAGGTTCCC
TGTGCCCTCCTCGAGGTGGGCAGCCATCACCAGCCACAGTTAAGCCAAGCCCCCCAACATGTATTCCATCGTGCTGGTAGAAGAGTCTTT
GCTGTTGCTCCCGAAAGCCGTGCTCTCCAGCCTGGCTGCCAGGGAGGGTGGGCCTCTTGGTTCCAGGCTCTTGAAATAGTGCAGCCTTTT
CTTCCTATCTCTGTGGCTTTCAGCTCTGCTTCCTTGGTTATTAGGAGAATAGATGGGTGATGTCTTTCCTTATGTTGCTTTTTCAACATA
GCAGAATTAATGTAGGGAGCTAAATCCAGTGGTGTGTGTGAATGCAGAAGGGAATGCACCCCACATTCCCATGATGGAAGTCTGCGTAAC

>22905_22905_5_DIS3L2-INPP5D_DIS3L2_chr2_233103355_ENST00000325385_INPP5D_chr2_234054804_ENST00000450745_length(amino acids)=1389AA_BP=451
MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK
KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA
QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN
SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS
SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQ
KVPGEANPINMVSKLSQLTSLLSSIEDKVKALLHEGPESPHRPSLIPPVTFEVKAESLGIPQKMQLKVDVESGKLIIKKSKDGSEDKFYS
HKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFLSKG
QGKTRDDSADYIPHDIYVIGTQEDPLSEKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGN
KGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQKIKQQQ
YADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSD
HSPVFATFEAGVTSQFVSKNGPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKFGETLPKLKPI
ISDPEYLLDQHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQTSQGKTREKLYDFVKTERDESSGPKT
LKSLTSHDPMKQWEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPI
SPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPSI
VLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKSPAV

--------------------------------------------------------------
>22905_22905_6_DIS3L2-INPP5D_DIS3L2_chr2_233103355_ENST00000325385_INPP5D_chr2_234054804_ENST00000455936_length(transcript)=5608nt_BP=1593nt
TTTCGCCCTTGTCGCAGCTGAACCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCAC
CGTCGCTCTCTAGAACGCCGCGCCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAA
ACGCGAATGACAACAGAGCTGCTCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAG
CCAATAATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATT
GGTGCTTCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGAT
GTTTCAGAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCG
GATGGTGATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAG
GAGCATTGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACAC
CATCTCCCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGA
CATGGCATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCG
GTTACAAAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATC
TTGGAGAAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTT
TCTCCCTCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAAC
ACACTGTTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAA
ATTGAGCCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGC
CTGCCATGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGA
GACCTCGATGATGCCCTCTCCTGCAAGCCACTCGCTGACGGCAACTTCAAAGTGGGAGTTCACATTGCTGACGTGAGTTACTTTGTTCCG
GAGGGATCTGATCTGGATAAAGTGGCTGCCGAGAGGGCTACAAGCGTCTACTTGGTTCAAAAGCAGGTTCCTGGTGAGGCCAATCCCATC
AACATGGTGTCCAAGCTCAGCCAACTGACAAGCCTGTTGTCGTCCATTGAAGACAAGGTCAAGGCCTTGCTGCACGAGGGTCCTGAGTCT
CCGCACCGGCCCTCCCTTATCCCTCCAGTCACCTTTGAGGTGAAGGCAGAGTCTCTGGGGATTCCTCAGAAAATGCAGCTCAAAGTCGAC
GTTGAGTCTGGGAAACTGATCATTAAGAAGTCCAAGGATGGTTCTGAGGACAAGTTCTACAGCCACAAGAAAATCCTGCAGCTCATTAAG
TCACAGAAATTTCTGAATAAGTTGGTGATCTTGGTGGAAACAGAGAAGGAGAAGATCCTGCGGAAGGAATATGTTTTTGCTGACTCCAAA
AAGAGAGAAGGCTTCTGCCAGCTCCTGCAGCAGATGAAGAACAAGCACTCAGAGCAGCCGGAGCCCGACATGATCACCATCTTCATCGGC
ACCTGGAACATGGGTAACGCCCCCCCTCCCAAGAAGATCACGTCCTGGTTTCTCTCCAAGGGGCAGGGAAAGACGCGGGACGACTCTGCG
GACTACATCCCCCATGACATTTACGTGATCGGCACCCAAGAGGACCCCCTGAGTGAGAAGGAGTGGCTGGAGATCCTCAAACACTCCCTG
CAAGAAATCACCAGTGTGACTTTTAAAACAGTCGCCATCCACACGCTCTGGAACATCCGCATCGTGGTGCTGGCCAAGCCTGAGCACGAG
AACCGGATCAGCCACATCTGTACTGACAACGTGAAGACAGGCATTGCAAACACACTGGGGAACAAGGGAGCCGTGGGGGTGTCGTTCATG
TTCAATGGAACCTCCTTAGGGTTCGTCAACAGCCACTTGACTTCAGGAAGTGAAAAGAAACTCAGGCGAAACCAAAACTATATGAACATT
CTCCGGTTCCTGGCCCTGGGCGACAAGAAGCTGAGTCCCTTTAACATCACTCACCGCTTCACGCACCTCTTCTGGTTTGGGGATCTTAAC
TACCGTGTGGATCTGCCTACCTGGGAGGCAGAAACCATCATCCAGAAAATCAAGCAGCAGCAGTACGCAGACCTCCTGTCCCACGACCAG
CTGCTCACAGAGAGGAGGGAGCAGAAGGTCTTCCTACACTTCGAGGAGGAAGAAATCACGTTTGCCCCAACCTACCGTTTTGAGAGACTG
ACTCGGGACAAATACGCCTACACCAAGCAGAAAGCGACAGGGATGAAGTACAACTTGCCTTCCTGGTGTGACCGAGTCCTCTGGAAGTCT
TATCCCCTGGTGCACGTGGTGTGTCAGTCTTATGGCAGTACCAGCGACATCATGACGAGTGACCACAGCCCTGTCTTTGCCACATTTGAG
GCAGGAGTCACTTCCCAGTTTGTCTCCAAGAACGGTCCCGGGACTGTTGACAGCCAAGGACAGATTGAGTTTCTCAGGTGCTATGCCACA
TTGAAGACCAAGTCCCAGACCAAATTCTACCTGGAGTTCCACTCGAGCTGCTTGGAGAGTTTTGTCAAGAGTCAGGAAGGAGAAAATGAA
GAAGGAAGTGAGGGGGAGCTGGTGGTGAAGTTTGGTGAGACTCTTCCAAAGCTGAAGCCCATTATCTCTGACCCTGAGTACCTGCTAGAC
CAGCACATCCTCATCAGCATCAAGTCCTCTGACAGCGACGAATCCTATGGCGAGGGCTGCATTGCCCTTCGGTTAGAGGCCACAGAAACG
CAGCTGCCCATCTACACGCCTCTCACCCACCATGGGGAGTTGACAGGCCACTTCCAGGGGGAGATCAAGCTGCAGACCTCTCAGGGCAAG
ACGAGGGAGAAGCTCTATGACTTTGTGAAGACGGAGCGTGATGAATCCAGTGGGCCAAAGACCCTGAAGAGCCTCACCAGCCACGACCCC
ATGAAGCAGTGGGAAGTCACTAGCAGGGCCCCTCCGTGCAGTGGCTCCAGCATCACTGAAATCATCAACCCCAACTACATGGGAGTGGGG
CCCTTTGGGCCACCAATGCCCCTGCACGTGAAGCAGACCTTGTCCCCTGACCAGCAGCCCACAGCCTGGAGCTACGACCAGCCGCCCAAG
GACTCCCCGCTGGGGCCCTGCAGGGGAGAAAGTCCTCCGACACCTCCCGGCCAGCCGCCCATATCACCCAAGAAGTTTTTACCCTCAACA
GCAAACCGGGGTCTCCCTCCCAGGACACAGGAGTCAAGGCCCAGTGACCTGGGGAAGAACGCAGGGGACACGCTGCCTCAGGAGGACCTG
CCGCTGACGAAGCCCGAGATGTTTGAGAACCCCCTGTATGGGTCCCTGAGTTCCTTCCCTAAGCCTGCTCCCAGGAAGGACCAGGAATCC
CCCAAAATGCCGCGGAAGGAACCCCCGCCCTGCCCGGAACCCGGCATCTTGTCGCCCAGCATCGTGCTCACCAAAGCCCAGGAGGCTGAT
CGCGGCGAGGGGCCCGGCAAGCAGGTGCCCGCGCCCCGGCTGCGCTCCTTCACGTGCTCATCCTCTGCCGAGGGCAGGGCGGCCGGCGGG
GACAAGAGCCAAGGGAAGCCCAAGACCCCGGTCAGCTCCCAGGCCCCGGTGCCGGCCAAGAGGCCCATCAAGCCTTCCAGATCGGAAATC
AACCAGCAGACCCCGCCCACCCCGACGCCGCGGCCGCCGCTGCCAGTCAAGAGCCCGGCGGTGCTGCACCTCCAGCACTCCAAGGGCCGC
GACTACCGCGACAACACCGAGCTCCCGCATCACGGCAAGCACCGGCCGGAGGAGGGGCCACCAGGGCCTCTAGGCAGGACTGCCATGCAG
TGAAGCCCTCAGTGAGCTGCCACTGAGTCGGGAGCCCAGAGGAACGGCGTGAAGCCACTGGACCCTCTCCCGGGACCTCCTGCTGGCTCC
TCCTGCCCAGCTTCCTATGCAAGGCTTTGTGTTTTCAGGAAAGGGCCTAGCTTCTGTGTGGCCCACAGAGTTCACTGCCTGTGAGACTTA
GCACCAAGTGCTGAGGCTGGAAGAAAAACGCACACCAGACGGGCAACAAACAGTCTGGGTCCCCAGCTCGCTCTTGGTACTTGGGACCCC
AGTGCCTCGTTGAGGGCGCCATTCTGAAGAAAGGAACTGCAGCGCCGATTTGAGGGTGGAGATATAGATAATAATAATATTAATAATAAT
AATGGCCACATGGATCGAACACTCATGATGTGCCAAGTGCTGTGCTAAGTGCTTTACGAACATTCGTCATATCAGGATGACCTCGAGAGC
TGAGGCTCTAGCCACCTAAAACCACGTGCCCAAACCCACCAGTTTAAAACGGTGTGTGTTCGGAGGGGTGAAAGCATTAAGAAGCCCAGT
GCCCTCCTGGAGTGAGACAAGGGCTCGGCCTTAAGGAGCTGAAGAGTCTGGGTAGCTTGTTTAGGGTACAAGAAGCCTGTTCTGTCCAGC
TTCAGTGACACAAGCTGCTTTAGCTAAAGTCCCGCGGGTTCCGGCATGGCTAGGCTGAGAGCAGGGATCTACCTGGCTTCTCAGTTCTTT
GGTTGGAAGGAGCAGGAAATCAGCTCCTATTCTCCAGTGGAGAGATCTGGCCTCAGCTTGGGCTAGAGATGCCAAGGCCTGTGCCAGGTT
CCCTGTGCCCTCCTCGAGGTGGGCAGCCATCACCAGCCACAGTTAAGCCAAGCCCCCCAACATGTATTCCATCGTGCTGGTAGAAGAGTC
TTTGCTGTTGCTCCCGAAAGCCGTGCTCTCCAGCCTGGCTGCCAGGGAGGGTGGGCCTCTTGGTTCCAGGCTCTTGAAATAGTGCAGCCT
TTTCTTCCTATCTCTGTGGCTTTCAGCTCTGCTTCCTTGGTTATTAGGAGAATAGATGGGTGATGTCTTTCCTTATGTTGCTTTTTCAAC
ATAGCAGAATTAATGTAGGGAGCTAAATCCAGTGGTGTGTGTGAATGCAGAAGGGAATGCACCCCACATTCCCATGATGGAAGTCTGCGT

>22905_22905_6_DIS3L2-INPP5D_DIS3L2_chr2_233103355_ENST00000325385_INPP5D_chr2_234054804_ENST00000455936_length(amino acids)=1390AA_BP=451
MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK
KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA
QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN
SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS
SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQ
KQVPGEANPINMVSKLSQLTSLLSSIEDKVKALLHEGPESPHRPSLIPPVTFEVKAESLGIPQKMQLKVDVESGKLIIKKSKDGSEDKFY
SHKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFLSK
GQGKTRDDSADYIPHDIYVIGTQEDPLSEKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLG
NKGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQKIKQQ
QYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTS
DHSPVFATFEAGVTSQFVSKNGPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKFGETLPKLKP
IISDPEYLLDQHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQTSQGKTREKLYDFVKTERDESSGPK
TLKSLTSHDPMKQWEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPP
ISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPS
IVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKSPA

--------------------------------------------------------------
>22905_22905_7_DIS3L2-INPP5D_DIS3L2_chr2_233103355_ENST00000409307_INPP5D_chr2_234054804_ENST00000359570_length(transcript)=5328nt_BP=1317nt
ATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCT
TCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCA
GAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGT
GATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCAT
TGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTC
CCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGC
ATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACA
AAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAG
AAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCC
TCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTG
TTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAG
CCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCA
TGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGAGACCTC
GATGATGCCCTCTCCTGCAAGCCACTCGCTGACGGCAACTTCAAAGTGGGAGTTCACATTGCTGACGTGAGTTACTTTGTTCCGGAGGGA
TCTGATCTGGATAAAGTGGCTGCCGAGAGGGCTACAAGCGTCTACTTGGTTCAAAAGGTTCCTGGTGAGGCCAATCCCATCAACATGGTG
TCCAAGCTCAGCCAACTGACAAGCCTGTTGTCGTCCATTGAAGACAAGGTCAAGGCCTTGCTGCACGAGGGTCCTGAGTCTCCGCACCGG
CCCTCCCTTATCCCTCCAGTCACCTTTGAGGTGAAGGCAGAGTCTCTGGGGATTCCTCAGAAAATGCAGCTCAAAGTCGACGTTGAGTCT
GGGAAACTGATCATTAAGAAGTCCAAGGATGGTTCTGAGGACAAGTTCTACAGCCACAAGAAAATCCTGCAGCTCATTAAGTCACAGAAA
TTTCTGAATAAGTTGGTGATCTTGGTGGAAACAGAGAAGGAGAAGATCCTGCGGAAGGAATATGTTTTTGCTGACTCCAAAAAGAGAGAA
GGCTTCTGCCAGCTCCTGCAGCAGATGAAGAACAAGCACTCAGAGCAGCCGGAGCCCGACATGATCACCATCTTCATCGGCACCTGGAAC
ATGGGTAACGCCCCCCCTCCCAAGAAGATCACGTCCTGGTTTCTCTCCAAGGGGCAGGGAAAGACGCGGGACGACTCTGCGGACTACATC
CCCCATGACATTTACGTGATCGGCACCCAAGAGGACCCCCTGAGTGAGAAGGAGTGGCTGGAGATCCTCAAACACTCCCTGCAAGAAATC
ACCAGTGTGACTTTTAAAACAGTCGCCATCCACACGCTCTGGAACATCCGCATCGTGGTGCTGGCCAAGCCTGAGCACGAGAACCGGATC
AGCCACATCTGTACTGACAACGTGAAGACAGGCATTGCAAACACACTGGGGAACAAGGGAGCCGTGGGGGTGTCGTTCATGTTCAATGGA
ACCTCCTTAGGGTTCGTCAACAGCCACTTGACTTCAGGAAGTGAAAAGAAACTCAGGCGAAACCAAAACTATATGAACATTCTCCGGTTC
CTGGCCCTGGGCGACAAGAAGCTGAGTCCCTTTAACATCACTCACCGCTTCACGCACCTCTTCTGGTTTGGGGATCTTAACTACCGTGTG
GATCTGCCTACCTGGGAGGCAGAAACCATCATCCAGAAAATCAAGCAGCAGCAGTACGCAGACCTCCTGTCCCACGACCAGCTGCTCACA
GAGAGGAGGGAGCAGAAGGTCTTCCTACACTTCGAGGAGGAAGAAATCACGTTTGCCCCAACCTACCGTTTTGAGAGACTGACTCGGGAC
AAATACGCCTACACCAAGCAGAAAGCGACAGGGATGAAGTACAACTTGCCTTCCTGGTGTGACCGAGTCCTCTGGAAGTCTTATCCCCTG
GTGCACGTGGTGTGTCAGTCTTATGGCAGTACCAGCGACATCATGACGAGTGACCACAGCCCTGTCTTTGCCACATTTGAGGCAGGAGTC
ACTTCCCAGTTTGTCTCCAAGAACGGTCCCGGGACTGTTGACAGCCAAGGACAGATTGAGTTTCTCAGGTGCTATGCCACATTGAAGACC
AAGTCCCAGACCAAATTCTACCTGGAGTTCCACTCGAGCTGCTTGGAGAGTTTTGTCAAGAGTCAGGAAGGAGAAAATGAAGAAGGAAGT
GAGGGGGAGCTGGTGGTGAAGTTTGGTGAGACTCTTCCAAAGCTGAAGCCCATTATCTCTGACCCTGAGTACCTGCTAGACCAGCACATC
CTCATCAGCATCAAGTCCTCTGACAGCGACGAATCCTATGGCGAGGGCTGCATTGCCCTTCGGTTAGAGGCCACAGAAACGCAGCTGCCC
ATCTACACGCCTCTCACCCACCATGGGGAGTTGACAGGCCACTTCCAGGGGGAGATCAAGCTGCAGACCTCTCAGGGCAAGACGAGGGAG
AAGCTCTATGACTTTGTGAAGACGGAGCGTGATGAATCCAGTGGGCCAAAGACCCTGAAGAGCCTCACCAGCCACGACCCCATGAAGCAG
TGGGAAGTCACTAGCAGGGCCCCTCCGTGCAGTGGCTCCAGCATCACTGAAATCATCAACCCCAACTACATGGGAGTGGGGCCCTTTGGG
CCACCAATGCCCCTGCACGTGAAGCAGACCTTGTCCCCTGACCAGCAGCCCACAGCCTGGAGCTACGACCAGCCGCCCAAGGACTCCCCG
CTGGGGCCCTGCAGGGGAGAAAGTCCTCCGACACCTCCCGGCCAGCCGCCCATATCACCCAAGAAGTTTTTACCCTCAACAGCAAACCGG
GGTCTCCCTCCCAGGACACAGGAGTCAAGGCCCAGTGACCTGGGGAAGAACGCAGGGGACACGCTGCCTCAGGAGGACCTGCCGCTGACG
AAGCCCGAGATGTTTGAGAACCCCCTGTATGGGTCCCTGAGTTCCTTCCCTAAGCCTGCTCCCAGGAAGGACCAGGAATCCCCCAAAATG
CCGCGGAAGGAACCCCCGCCCTGCCCGGAACCCGGCATCTTGTCGCCCAGCATCGTGCTCACCAAAGCCCAGGAGGCTGATCGCGGCGAG
GGGCCCGGCAAGCAGGTGCCCGCGCCCCGGCTGCGCTCCTTCACGTGCTCATCCTCTGCCGAGGGCAGGGCGGCCGGCGGGGACAAGAGC
CAAGGGAAGCCCAAGACCCCGGTCAGCTCCCAGGCCCCGGTGCCGGCCAAGAGGCCCATCAAGCCTTCCAGATCGGAAATCAACCAGCAG
ACCCCGCCCACCCCGACGCCGCGGCCGCCGCTGCCAGTCAAGAGCCCGGCGGTGCTGCACCTCCAGCACTCCAAGGGCCGCGACTACCGC
GACAACACCGAGCTCCCGCATCACGGCAAGCACCGGCCGGAGGAGGGGCCACCAGGGCCTCTAGGCAGGACTGCCATGCAGTGAAGCCCT
CAGTGAGCTGCCACTGAGTCGGGAGCCCAGAGGAACGGCGTGAAGCCACTGGACCCTCTCCCGGGACCTCCTGCTGGCTCCTCCTGCCCA
GCTTCCTATGCAAGGCTTTGTGTTTTCAGGAAAGGGCCTAGCTTCTGTGTGGCCCACAGAGTTCACTGCCTGTGAGACTTAGCACCAAGT
GCTGAGGCTGGAAGAAAAACGCACACCAGACGGGCAACAAACAGTCTGGGTCCCCAGCTCGCTCTTGGTACTTGGGACCCCAGTGCCTCG
TTGAGGGCGCCATTCTGAAGAAAGGAACTGCAGCGCCGATTTGAGGGTGGAGATATAGATAATAATAATATTAATAATAATAATGGCCAC
ATGGATCGAACACTCATGATGTGCCAAGTGCTGTGCTAAGTGCTTTACGAACATTCGTCATATCAGGATGACCTCGAGAGCTGAGGCTCT
AGCCACCTAAAACCACGTGCCCAAACCCACCAGTTTAAAACGGTGTGTGTTCGGAGGGGTGAAAGCATTAAGAAGCCCAGTGCCCTCCTG
GAGTGAGACAAGGGCTCGGCCTTAAGGAGCTGAAGAGTCTGGGTAGCTTGTTTAGGGTACAAGAAGCCTGTTCTGTCCAGCTTCAGTGAC
ACAAGCTGCTTTAGCTAAAGTCCCGCGGGTTCCGGCATGGCTAGGCTGAGAGCAGGGATCTACCTGGCTTCTCAGTTCTTTGGTTGGAAG
GAGCAGGAAATCAGCTCCTATTCTCCAGTGGAGAGATCTGGCCTCAGCTTGGGCTAGAGATGCCAAGGCCTGTGCCAGGTTCCCTGTGCC
CTCCTCGAGGTGGGCAGCCATCACCAGCCACAGTTAAGCCAAGCCCCCCAACATGTATTCCATCGTGCTGGTAGAAGAGTCTTTGCTGTT
GCTCCCGAAAGCCGTGCTCTCCAGCCTGGCTGCCAGGGAGGGTGGGCCTCTTGGTTCCAGGCTCTTGAAATAGTGCAGCCTTTTCTTCCT
ATCTCTGTGGCTTTCAGCTCTGCTTCCTTGGTTATTAGGAGAATAGATGGGTGATGTCTTTCCTTATGTTGCTTTTTCAACATAGCAGAA
TTAATGTAGGGAGCTAAATCCAGTGGTGTGTGTGAATGCAGAAGGGAATGCACCCCACATTCCCATGATGGAAGTCTGCGTAACCAATAA

>22905_22905_7_DIS3L2-INPP5D_DIS3L2_chr2_233103355_ENST00000409307_INPP5D_chr2_234054804_ENST00000359570_length(amino acids)=1377AA_BP=439
MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG
DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG
ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP
SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP
WTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQKVPGEANPINMV
SKLSQLTSLLSSIEDKVKALLHEGPESPHRPSLIPPVTFEVKAESLGIPQKMQLKVDVESGKLIIKKSKDGSEDKFYSHKKILQLIKSQK
FLNKLVILVETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYI
PHDIYVIGTQEDPLSEKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNG
TSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQKIKQQQYADLLSHDQLLT
ERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGV
TSQFVSKNGPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKFGETLPKLKPIISDPEYLLDQHI
LISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQTSQGKTREKLYDFVKTERDESSGPKTLKSLTSHDPMKQ
WEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPISPKKFLPSTANR
GLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPSIVLTKAQEADRGE
GPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKSPAVLHLQHSKGRDYR

--------------------------------------------------------------
>22905_22905_8_DIS3L2-INPP5D_DIS3L2_chr2_233103355_ENST00000409307_INPP5D_chr2_234054804_ENST00000450745_length(transcript)=5328nt_BP=1317nt
ATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCT
TCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCA
GAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGT
GATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCAT
TGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTC
CCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGC
ATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACA
AAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAG
AAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCC
TCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTG
TTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAG
CCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCA
TGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGAGACCTC
GATGATGCCCTCTCCTGCAAGCCACTCGCTGACGGCAACTTCAAAGTGGGAGTTCACATTGCTGACGTGAGTTACTTTGTTCCGGAGGGA
TCTGATCTGGATAAAGTGGCTGCCGAGAGGGCTACAAGCGTCTACTTGGTTCAAAAGGTTCCTGGTGAGGCCAATCCCATCAACATGGTG
TCCAAGCTCAGCCAACTGACAAGCCTGTTGTCGTCCATTGAAGACAAGGTCAAGGCCTTGCTGCACGAGGGTCCTGAGTCTCCGCACCGG
CCCTCCCTTATCCCTCCAGTCACCTTTGAGGTGAAGGCAGAGTCTCTGGGGATTCCTCAGAAAATGCAGCTCAAAGTCGACGTTGAGTCT
GGGAAACTGATCATTAAGAAGTCCAAGGATGGTTCTGAGGACAAGTTCTACAGCCACAAGAAAATCCTGCAGCTCATTAAGTCACAGAAA
TTTCTGAATAAGTTGGTGATCTTGGTGGAAACAGAGAAGGAGAAGATCCTGCGGAAGGAATATGTTTTTGCTGACTCCAAAAAGAGAGAA
GGCTTCTGCCAGCTCCTGCAGCAGATGAAGAACAAGCACTCAGAGCAGCCGGAGCCCGACATGATCACCATCTTCATCGGCACCTGGAAC
ATGGGTAACGCCCCCCCTCCCAAGAAGATCACGTCCTGGTTTCTCTCCAAGGGGCAGGGAAAGACGCGGGACGACTCTGCGGACTACATC
CCCCATGACATTTACGTGATCGGCACCCAAGAGGACCCCCTGAGTGAGAAGGAGTGGCTGGAGATCCTCAAACACTCCCTGCAAGAAATC
ACCAGTGTGACTTTTAAAACAGTCGCCATCCACACGCTCTGGAACATCCGCATCGTGGTGCTGGCCAAGCCTGAGCACGAGAACCGGATC
AGCCACATCTGTACTGACAACGTGAAGACAGGCATTGCAAACACACTGGGGAACAAGGGAGCCGTGGGGGTGTCGTTCATGTTCAATGGA
ACCTCCTTAGGGTTCGTCAACAGCCACTTGACTTCAGGAAGTGAAAAGAAACTCAGGCGAAACCAAAACTATATGAACATTCTCCGGTTC
CTGGCCCTGGGCGACAAGAAGCTGAGTCCCTTTAACATCACTCACCGCTTCACGCACCTCTTCTGGTTTGGGGATCTTAACTACCGTGTG
GATCTGCCTACCTGGGAGGCAGAAACCATCATCCAGAAAATCAAGCAGCAGCAGTACGCAGACCTCCTGTCCCACGACCAGCTGCTCACA
GAGAGGAGGGAGCAGAAGGTCTTCCTACACTTCGAGGAGGAAGAAATCACGTTTGCCCCAACCTACCGTTTTGAGAGACTGACTCGGGAC
AAATACGCCTACACCAAGCAGAAAGCGACAGGGATGAAGTACAACTTGCCTTCCTGGTGTGACCGAGTCCTCTGGAAGTCTTATCCCCTG
GTGCACGTGGTGTGTCAGTCTTATGGCAGTACCAGCGACATCATGACGAGTGACCACAGCCCTGTCTTTGCCACATTTGAGGCAGGAGTC
ACTTCCCAGTTTGTCTCCAAGAACGGTCCCGGGACTGTTGACAGCCAAGGACAGATTGAGTTTCTCAGGTGCTATGCCACATTGAAGACC
AAGTCCCAGACCAAATTCTACCTGGAGTTCCACTCGAGCTGCTTGGAGAGTTTTGTCAAGAGTCAGGAAGGAGAAAATGAAGAAGGAAGT
GAGGGGGAGCTGGTGGTGAAGTTTGGTGAGACTCTTCCAAAGCTGAAGCCCATTATCTCTGACCCTGAGTACCTGCTAGACCAGCACATC
CTCATCAGCATCAAGTCCTCTGACAGCGACGAATCCTATGGCGAGGGCTGCATTGCCCTTCGGTTAGAGGCCACAGAAACGCAGCTGCCC
ATCTACACGCCTCTCACCCACCATGGGGAGTTGACAGGCCACTTCCAGGGGGAGATCAAGCTGCAGACCTCTCAGGGCAAGACGAGGGAG
AAGCTCTATGACTTTGTGAAGACGGAGCGTGATGAATCCAGTGGGCCAAAGACCCTGAAGAGCCTCACCAGCCACGACCCCATGAAGCAG
TGGGAAGTCACTAGCAGGGCCCCTCCGTGCAGTGGCTCCAGCATCACTGAAATCATCAACCCCAACTACATGGGAGTGGGGCCCTTTGGG
CCACCAATGCCCCTGCACGTGAAGCAGACCTTGTCCCCTGACCAGCAGCCCACAGCCTGGAGCTACGACCAGCCGCCCAAGGACTCCCCG
CTGGGGCCCTGCAGGGGAGAAAGTCCTCCGACACCTCCCGGCCAGCCGCCCATATCACCCAAGAAGTTTTTACCCTCAACAGCAAACCGG
GGTCTCCCTCCCAGGACACAGGAGTCAAGGCCCAGTGACCTGGGGAAGAACGCAGGGGACACGCTGCCTCAGGAGGACCTGCCGCTGACG
AAGCCCGAGATGTTTGAGAACCCCCTGTATGGGTCCCTGAGTTCCTTCCCTAAGCCTGCTCCCAGGAAGGACCAGGAATCCCCCAAAATG
CCGCGGAAGGAACCCCCGCCCTGCCCGGAACCCGGCATCTTGTCGCCCAGCATCGTGCTCACCAAAGCCCAGGAGGCTGATCGCGGCGAG
GGGCCCGGCAAGCAGGTGCCCGCGCCCCGGCTGCGCTCCTTCACGTGCTCATCCTCTGCCGAGGGCAGGGCGGCCGGCGGGGACAAGAGC
CAAGGGAAGCCCAAGACCCCGGTCAGCTCCCAGGCCCCGGTGCCGGCCAAGAGGCCCATCAAGCCTTCCAGATCGGAAATCAACCAGCAG
ACCCCGCCCACCCCGACGCCGCGGCCGCCGCTGCCAGTCAAGAGCCCGGCGGTGCTGCACCTCCAGCACTCCAAGGGCCGCGACTACCGC
GACAACACCGAGCTCCCGCATCACGGCAAGCACCGGCCGGAGGAGGGGCCACCAGGGCCTCTAGGCAGGACTGCCATGCAGTGAAGCCCT
CAGTGAGCTGCCACTGAGTCGGGAGCCCAGAGGAACGGCGTGAAGCCACTGGACCCTCTCCCGGGACCTCCTGCTGGCTCCTCCTGCCCA
GCTTCCTATGCAAGGCTTTGTGTTTTCAGGAAAGGGCCTAGCTTCTGTGTGGCCCACAGAGTTCACTGCCTGTGAGACTTAGCACCAAGT
GCTGAGGCTGGAAGAAAAACGCACACCAGACGGGCAACAAACAGTCTGGGTCCCCAGCTCGCTCTTGGTACTTGGGACCCCAGTGCCTCG
TTGAGGGCGCCATTCTGAAGAAAGGAACTGCAGCGCCGATTTGAGGGTGGAGATATAGATAATAATAATATTAATAATAATAATGGCCAC
ATGGATCGAACACTCATGATGTGCCAAGTGCTGTGCTAAGTGCTTTACGAACATTCGTCATATCAGGATGACCTCGAGAGCTGAGGCTCT
AGCCACCTAAAACCACGTGCCCAAACCCACCAGTTTAAAACGGTGTGTGTTCGGAGGGGTGAAAGCATTAAGAAGCCCAGTGCCCTCCTG
GAGTGAGACAAGGGCTCGGCCTTAAGGAGCTGAAGAGTCTGGGTAGCTTGTTTAGGGTACAAGAAGCCTGTTCTGTCCAGCTTCAGTGAC
ACAAGCTGCTTTAGCTAAAGTCCCGCGGGTTCCGGCATGGCTAGGCTGAGAGCAGGGATCTACCTGGCTTCTCAGTTCTTTGGTTGGAAG
GAGCAGGAAATCAGCTCCTATTCTCCAGTGGAGAGATCTGGCCTCAGCTTGGGCTAGAGATGCCAAGGCCTGTGCCAGGTTCCCTGTGCC
CTCCTCGAGGTGGGCAGCCATCACCAGCCACAGTTAAGCCAAGCCCCCCAACATGTATTCCATCGTGCTGGTAGAAGAGTCTTTGCTGTT
GCTCCCGAAAGCCGTGCTCTCCAGCCTGGCTGCCAGGGAGGGTGGGCCTCTTGGTTCCAGGCTCTTGAAATAGTGCAGCCTTTTCTTCCT
ATCTCTGTGGCTTTCAGCTCTGCTTCCTTGGTTATTAGGAGAATAGATGGGTGATGTCTTTCCTTATGTTGCTTTTTCAACATAGCAGAA
TTAATGTAGGGAGCTAAATCCAGTGGTGTGTGTGAATGCAGAAGGGAATGCACCCCACATTCCCATGATGGAAGTCTGCGTAACCAATAA

>22905_22905_8_DIS3L2-INPP5D_DIS3L2_chr2_233103355_ENST00000409307_INPP5D_chr2_234054804_ENST00000450745_length(amino acids)=1377AA_BP=439
MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG
DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG
ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP
SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP
WTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQKVPGEANPINMV
SKLSQLTSLLSSIEDKVKALLHEGPESPHRPSLIPPVTFEVKAESLGIPQKMQLKVDVESGKLIIKKSKDGSEDKFYSHKKILQLIKSQK
FLNKLVILVETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYI
PHDIYVIGTQEDPLSEKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNG
TSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQKIKQQQYADLLSHDQLLT
ERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGV
TSQFVSKNGPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKFGETLPKLKPIISDPEYLLDQHI
LISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQTSQGKTREKLYDFVKTERDESSGPKTLKSLTSHDPMKQ
WEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPISPKKFLPSTANR
GLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPSIVLTKAQEADRGE
GPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKSPAVLHLQHSKGRDYR

--------------------------------------------------------------
>22905_22905_9_DIS3L2-INPP5D_DIS3L2_chr2_233103355_ENST00000409307_INPP5D_chr2_234054804_ENST00000455936_length(transcript)=5332nt_BP=1317nt
ATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCT
TCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCA
GAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGT
GATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCAT
TGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTC
CCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGC
ATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACA
AAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAG
AAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCC
TCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTG
TTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAG
CCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCA
TGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGAGACCTC
GATGATGCCCTCTCCTGCAAGCCACTCGCTGACGGCAACTTCAAAGTGGGAGTTCACATTGCTGACGTGAGTTACTTTGTTCCGGAGGGA
TCTGATCTGGATAAAGTGGCTGCCGAGAGGGCTACAAGCGTCTACTTGGTTCAAAAGCAGGTTCCTGGTGAGGCCAATCCCATCAACATG
GTGTCCAAGCTCAGCCAACTGACAAGCCTGTTGTCGTCCATTGAAGACAAGGTCAAGGCCTTGCTGCACGAGGGTCCTGAGTCTCCGCAC
CGGCCCTCCCTTATCCCTCCAGTCACCTTTGAGGTGAAGGCAGAGTCTCTGGGGATTCCTCAGAAAATGCAGCTCAAAGTCGACGTTGAG
TCTGGGAAACTGATCATTAAGAAGTCCAAGGATGGTTCTGAGGACAAGTTCTACAGCCACAAGAAAATCCTGCAGCTCATTAAGTCACAG
AAATTTCTGAATAAGTTGGTGATCTTGGTGGAAACAGAGAAGGAGAAGATCCTGCGGAAGGAATATGTTTTTGCTGACTCCAAAAAGAGA
GAAGGCTTCTGCCAGCTCCTGCAGCAGATGAAGAACAAGCACTCAGAGCAGCCGGAGCCCGACATGATCACCATCTTCATCGGCACCTGG
AACATGGGTAACGCCCCCCCTCCCAAGAAGATCACGTCCTGGTTTCTCTCCAAGGGGCAGGGAAAGACGCGGGACGACTCTGCGGACTAC
ATCCCCCATGACATTTACGTGATCGGCACCCAAGAGGACCCCCTGAGTGAGAAGGAGTGGCTGGAGATCCTCAAACACTCCCTGCAAGAA
ATCACCAGTGTGACTTTTAAAACAGTCGCCATCCACACGCTCTGGAACATCCGCATCGTGGTGCTGGCCAAGCCTGAGCACGAGAACCGG
ATCAGCCACATCTGTACTGACAACGTGAAGACAGGCATTGCAAACACACTGGGGAACAAGGGAGCCGTGGGGGTGTCGTTCATGTTCAAT
GGAACCTCCTTAGGGTTCGTCAACAGCCACTTGACTTCAGGAAGTGAAAAGAAACTCAGGCGAAACCAAAACTATATGAACATTCTCCGG
TTCCTGGCCCTGGGCGACAAGAAGCTGAGTCCCTTTAACATCACTCACCGCTTCACGCACCTCTTCTGGTTTGGGGATCTTAACTACCGT
GTGGATCTGCCTACCTGGGAGGCAGAAACCATCATCCAGAAAATCAAGCAGCAGCAGTACGCAGACCTCCTGTCCCACGACCAGCTGCTC
ACAGAGAGGAGGGAGCAGAAGGTCTTCCTACACTTCGAGGAGGAAGAAATCACGTTTGCCCCAACCTACCGTTTTGAGAGACTGACTCGG
GACAAATACGCCTACACCAAGCAGAAAGCGACAGGGATGAAGTACAACTTGCCTTCCTGGTGTGACCGAGTCCTCTGGAAGTCTTATCCC
CTGGTGCACGTGGTGTGTCAGTCTTATGGCAGTACCAGCGACATCATGACGAGTGACCACAGCCCTGTCTTTGCCACATTTGAGGCAGGA
GTCACTTCCCAGTTTGTCTCCAAGAACGGTCCCGGGACTGTTGACAGCCAAGGACAGATTGAGTTTCTCAGGTGCTATGCCACATTGAAG
ACCAAGTCCCAGACCAAATTCTACCTGGAGTTCCACTCGAGCTGCTTGGAGAGTTTTGTCAAGAGTCAGGAAGGAGAAAATGAAGAAGGA
AGTGAGGGGGAGCTGGTGGTGAAGTTTGGTGAGACTCTTCCAAAGCTGAAGCCCATTATCTCTGACCCTGAGTACCTGCTAGACCAGCAC
ATCCTCATCAGCATCAAGTCCTCTGACAGCGACGAATCCTATGGCGAGGGCTGCATTGCCCTTCGGTTAGAGGCCACAGAAACGCAGCTG
CCCATCTACACGCCTCTCACCCACCATGGGGAGTTGACAGGCCACTTCCAGGGGGAGATCAAGCTGCAGACCTCTCAGGGCAAGACGAGG
GAGAAGCTCTATGACTTTGTGAAGACGGAGCGTGATGAATCCAGTGGGCCAAAGACCCTGAAGAGCCTCACCAGCCACGACCCCATGAAG
CAGTGGGAAGTCACTAGCAGGGCCCCTCCGTGCAGTGGCTCCAGCATCACTGAAATCATCAACCCCAACTACATGGGAGTGGGGCCCTTT
GGGCCACCAATGCCCCTGCACGTGAAGCAGACCTTGTCCCCTGACCAGCAGCCCACAGCCTGGAGCTACGACCAGCCGCCCAAGGACTCC
CCGCTGGGGCCCTGCAGGGGAGAAAGTCCTCCGACACCTCCCGGCCAGCCGCCCATATCACCCAAGAAGTTTTTACCCTCAACAGCAAAC
CGGGGTCTCCCTCCCAGGACACAGGAGTCAAGGCCCAGTGACCTGGGGAAGAACGCAGGGGACACGCTGCCTCAGGAGGACCTGCCGCTG
ACGAAGCCCGAGATGTTTGAGAACCCCCTGTATGGGTCCCTGAGTTCCTTCCCTAAGCCTGCTCCCAGGAAGGACCAGGAATCCCCCAAA
ATGCCGCGGAAGGAACCCCCGCCCTGCCCGGAACCCGGCATCTTGTCGCCCAGCATCGTGCTCACCAAAGCCCAGGAGGCTGATCGCGGC
GAGGGGCCCGGCAAGCAGGTGCCCGCGCCCCGGCTGCGCTCCTTCACGTGCTCATCCTCTGCCGAGGGCAGGGCGGCCGGCGGGGACAAG
AGCCAAGGGAAGCCCAAGACCCCGGTCAGCTCCCAGGCCCCGGTGCCGGCCAAGAGGCCCATCAAGCCTTCCAGATCGGAAATCAACCAG
CAGACCCCGCCCACCCCGACGCCGCGGCCGCCGCTGCCAGTCAAGAGCCCGGCGGTGCTGCACCTCCAGCACTCCAAGGGCCGCGACTAC
CGCGACAACACCGAGCTCCCGCATCACGGCAAGCACCGGCCGGAGGAGGGGCCACCAGGGCCTCTAGGCAGGACTGCCATGCAGTGAAGC
CCTCAGTGAGCTGCCACTGAGTCGGGAGCCCAGAGGAACGGCGTGAAGCCACTGGACCCTCTCCCGGGACCTCCTGCTGGCTCCTCCTGC
CCAGCTTCCTATGCAAGGCTTTGTGTTTTCAGGAAAGGGCCTAGCTTCTGTGTGGCCCACAGAGTTCACTGCCTGTGAGACTTAGCACCA
AGTGCTGAGGCTGGAAGAAAAACGCACACCAGACGGGCAACAAACAGTCTGGGTCCCCAGCTCGCTCTTGGTACTTGGGACCCCAGTGCC
TCGTTGAGGGCGCCATTCTGAAGAAAGGAACTGCAGCGCCGATTTGAGGGTGGAGATATAGATAATAATAATATTAATAATAATAATGGC
CACATGGATCGAACACTCATGATGTGCCAAGTGCTGTGCTAAGTGCTTTACGAACATTCGTCATATCAGGATGACCTCGAGAGCTGAGGC
TCTAGCCACCTAAAACCACGTGCCCAAACCCACCAGTTTAAAACGGTGTGTGTTCGGAGGGGTGAAAGCATTAAGAAGCCCAGTGCCCTC
CTGGAGTGAGACAAGGGCTCGGCCTTAAGGAGCTGAAGAGTCTGGGTAGCTTGTTTAGGGTACAAGAAGCCTGTTCTGTCCAGCTTCAGT
GACACAAGCTGCTTTAGCTAAAGTCCCGCGGGTTCCGGCATGGCTAGGCTGAGAGCAGGGATCTACCTGGCTTCTCAGTTCTTTGGTTGG
AAGGAGCAGGAAATCAGCTCCTATTCTCCAGTGGAGAGATCTGGCCTCAGCTTGGGCTAGAGATGCCAAGGCCTGTGCCAGGTTCCCTGT
GCCCTCCTCGAGGTGGGCAGCCATCACCAGCCACAGTTAAGCCAAGCCCCCCAACATGTATTCCATCGTGCTGGTAGAAGAGTCTTTGCT
GTTGCTCCCGAAAGCCGTGCTCTCCAGCCTGGCTGCCAGGGAGGGTGGGCCTCTTGGTTCCAGGCTCTTGAAATAGTGCAGCCTTTTCTT
CCTATCTCTGTGGCTTTCAGCTCTGCTTCCTTGGTTATTAGGAGAATAGATGGGTGATGTCTTTCCTTATGTTGCTTTTTCAACATAGCA
GAATTAATGTAGGGAGCTAAATCCAGTGGTGTGTGTGAATGCAGAAGGGAATGCACCCCACATTCCCATGATGGAAGTCTGCGTAACCAA

>22905_22905_9_DIS3L2-INPP5D_DIS3L2_chr2_233103355_ENST00000409307_INPP5D_chr2_234054804_ENST00000455936_length(amino acids)=1378AA_BP=439
MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG
DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG
ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP
SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP
WTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQKQVPGEANPINM
VSKLSQLTSLLSSIEDKVKALLHEGPESPHRPSLIPPVTFEVKAESLGIPQKMQLKVDVESGKLIIKKSKDGSEDKFYSHKKILQLIKSQ
KFLNKLVILVETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADY
IPHDIYVIGTQEDPLSEKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFN
GTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQKIKQQQYADLLSHDQLL
TERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAG
VTSQFVSKNGPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKFGETLPKLKPIISDPEYLLDQH
ILISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQTSQGKTREKLYDFVKTERDESSGPKTLKSLTSHDPMK
QWEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPISPKKFLPSTAN
RGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPSIVLTKAQEADRG
EGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKSPAVLHLQHSKGRDY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DIS3L2-INPP5D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneINPP5Dchr2:233103355chr2:234054804ENST000003595707291016_1030239.01178.0DAB2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DIS3L2-INPP5D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DIS3L2-INPP5D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource