FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:DIS3L2-LRRFIP1 (FusionGDB2 ID:22906)

Fusion Gene Summary for DIS3L2-LRRFIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: DIS3L2-LRRFIP1
Fusion gene ID: 22906
HgeneTgene
Gene symbol

DIS3L2

LRRFIP1

Gene ID

129563

9208

Gene nameDIS3 like 3'-5' exoribonuclease 2LRR binding FLII interacting protein 1
SynonymsFAM6A|PRLMNS|hDIS3L2FLAP-1|FLAP1|FLIIAP1|GCF-2|GCF2|HUFI-1|TRIP
Cytomap

2q37.1

2q37.3

Type of geneprotein-codingprotein-coding
DescriptionDIS3-like exonuclease 2DIS3 mitotic control homolog-like 2family with sequence similarity 6, member Aleucine-rich repeat flightless-interacting protein 1GC-binding factor 2LRR FLII-interacting protein 1NEDD8-conjugating enzymeTAR RNA-interacting proteinleucine rich repeat (in FLII) interacting protein 1
Modification date2020031320200313
UniProtAcc

Q8IYB7

Q32MZ4

Ensembl transtripts involved in fusion geneENST00000470087, ENST00000273009, 
ENST00000325385, ENST00000360410, 
ENST00000409307, ENST00000409401, 
ENST00000308482, ENST00000244815, 
ENST00000289175, ENST00000392000, 
ENST00000468950, 
Fusion gene scores* DoF score27 X 9 X 12=291614 X 13 X 6=1092
# samples 2515
** MAII scorelog2(25/2916*10)=-3.54399071966485
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1092*10)=-2.86393845042397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DIS3L2 [Title/Abstract] AND LRRFIP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDIS3L2(232894790)-LRRFIP1(238617186), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDIS3L2

GO:0010587

miRNA catabolic process

24141620

TgeneLRRFIP1

GO:0000122

negative regulation of transcription by RNA polymerase II

14522076


check buttonFusion gene breakpoints across DIS3L2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRRFIP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-10-0936DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+


Top

Fusion Gene ORF analysis for DIS3L2-LRRFIP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000470087ENST00000308482DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
3UTR-intronENST00000470087ENST00000244815DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
3UTR-intronENST00000470087ENST00000289175DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
3UTR-intronENST00000470087ENST00000392000DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
3UTR-intronENST00000470087ENST00000468950DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
5CDS-intronENST00000273009ENST00000244815DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
5CDS-intronENST00000273009ENST00000289175DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
5CDS-intronENST00000273009ENST00000392000DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
5CDS-intronENST00000273009ENST00000468950DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
5CDS-intronENST00000325385ENST00000244815DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
5CDS-intronENST00000325385ENST00000289175DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
5CDS-intronENST00000325385ENST00000392000DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
5CDS-intronENST00000325385ENST00000468950DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
5CDS-intronENST00000360410ENST00000244815DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
5CDS-intronENST00000360410ENST00000289175DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
5CDS-intronENST00000360410ENST00000392000DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
5CDS-intronENST00000360410ENST00000468950DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
5CDS-intronENST00000409307ENST00000244815DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
5CDS-intronENST00000409307ENST00000289175DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
5CDS-intronENST00000409307ENST00000392000DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
5CDS-intronENST00000409307ENST00000468950DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
5CDS-intronENST00000409401ENST00000244815DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
5CDS-intronENST00000409401ENST00000289175DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
5CDS-intronENST00000409401ENST00000392000DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
5CDS-intronENST00000409401ENST00000468950DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
In-frameENST00000273009ENST00000308482DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
In-frameENST00000325385ENST00000308482DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
In-frameENST00000360410ENST00000308482DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
In-frameENST00000409307ENST00000308482DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+
In-frameENST00000409401ENST00000308482DIS3L2chr2

232894790

+LRRFIP1chr2

238617186

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000273009DIS3L2chr2232894790+ENST00000308482LRRFIP1chr2238617186+35909805782806742
ENST00000360410DIS3L2chr2232894790+ENST00000308482LRRFIP1chr2238617186+32526422402468742
ENST00000325385DIS3L2chr2232894790+ENST00000308482LRRFIP1chr2238617186+32526422402468742
ENST00000409401DIS3L2chr2232894790+ENST00000308482LRRFIP1chr2238617186+31515411392367742
ENST00000409307DIS3L2chr2232894790+ENST00000308482LRRFIP1chr2238617186+297636602192730

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000273009ENST00000308482DIS3L2chr2232894790+LRRFIP1chr2238617186+0.0024766370.99752337
ENST00000360410ENST00000308482DIS3L2chr2232894790+LRRFIP1chr2238617186+0.0021376680.9978624
ENST00000325385ENST00000308482DIS3L2chr2232894790+LRRFIP1chr2238617186+0.0021376680.9978624
ENST00000409401ENST00000308482DIS3L2chr2232894790+LRRFIP1chr2238617186+0.0019458880.99805415
ENST00000409307ENST00000308482DIS3L2chr2232894790+LRRFIP1chr2238617186+0.0016196840.9983803

Top

Fusion Genomic Features for DIS3L2-LRRFIP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DIS3L2chr2232894790+LRRFIP1chr2238617186+1.31E-101
DIS3L2chr2232894790+LRRFIP1chr2238617186+1.31E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for DIS3L2-LRRFIP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:232894790/chr2:238617186)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DIS3L2

Q8IYB7

LRRFIP1

Q32MZ4

FUNCTION: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. {ECO:0000255|HAMAP-Rule:MF_03045, ECO:0000269|PubMed:23756462, ECO:0000269|PubMed:24141620}.FUNCTION: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRRFIP1chr2:232894790chr2:238617186ENST00000244815010128_25022785.0Coiled coilOntology_term=ECO:0000269
TgeneLRRFIP1chr2:232894790chr2:238617186ENST0000028917508128_25022753.0Coiled coilOntology_term=ECO:0000269
TgeneLRRFIP1chr2:232894790chr2:238617186ENST00000308482024128_25032641.0Coiled coilOntology_term=ECO:0000269
TgeneLRRFIP1chr2:232894790chr2:238617186ENST00000392000011128_25022809.0Coiled coilOntology_term=ECO:0000269
TgeneLRRFIP1chr2:232894790chr2:238617186ENST00000244815010567_59322785.0Compositional biasNote=Lys-rich
TgeneLRRFIP1chr2:232894790chr2:238617186ENST0000028917508567_59322753.0Compositional biasNote=Lys-rich
TgeneLRRFIP1chr2:232894790chr2:238617186ENST00000308482024567_59332641.0Compositional biasNote=Lys-rich
TgeneLRRFIP1chr2:232894790chr2:238617186ENST00000392000011567_59322809.0Compositional biasNote=Lys-rich
TgeneLRRFIP1chr2:232894790chr2:238617186ENST00000244815010485_58422785.0RegionNote=DNA-binding
TgeneLRRFIP1chr2:232894790chr2:238617186ENST0000028917508485_58422753.0RegionNote=DNA-binding
TgeneLRRFIP1chr2:232894790chr2:238617186ENST00000308482024485_58432641.0RegionNote=DNA-binding
TgeneLRRFIP1chr2:232894790chr2:238617186ENST00000392000011485_58422809.0RegionNote=DNA-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for DIS3L2-LRRFIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22906_22906_1_DIS3L2-LRRFIP1_DIS3L2_chr2_232894790_ENST00000273009_LRRFIP1_chr2_238617186_ENST00000308482_length(transcript)=3590nt_BP=980nt
ATGCGGGGGTTGTCCATCTCTGTATCCCCAGTGCCAGCACTGCACCTCGCCCCAAGCAGTTGTCCAATAAATGAGCAGTGAGTAAATGAA
AGAATGAGCAAAGCCTTGTAACAGGAAAGGGGCCGGCGGCGTCTGCCGTGCAAGACCTGGCCCAGTGGAGCAGAGCCTGGAGGTTCAGGA
GCCGGGTCTGGAAGGCTCCTTCCGGTGGAAGAGGGGCCCGGAGCCAGCCGGCGCCTGGCACAAGGCGTCTCAGAGGCCGCCCACTGGGAG
CCAACCGTTGCAGCCAGTTGTCCCCGCGAGCGAGGCCGGAGAAGGCGCGGCGGCCCCTGGCCTGGCCATTTCGCCCTTGTCGCAGCTGAA
CCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCACCGTCGCTCTCTAGAACGCCGCG
CCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAAACGCGAATGACAACAGAGCTGC
TCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAGCCAATAATGAGCCATCCTGACT
ACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCTTCGCCAGGTGACAAAA
AGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCAGAAGGCTTGAAGAGAG
GAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGTGATCGAGACATTTTTA
TTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCATTGGAAGGCGGAAGCCC
GGCTCGCTGCAAAACGGGCGGCCCGCGCGGAGGCTCGCGAGATCCGCATGAAGGAGCTGGAGCGGCAGCAGAAGGAGATCTATCAGGTCC
AAAAGAAATATTATGGGCTGGATACAAAATGGGGTGACATCGAGCAGTGGATGGAAGACAGTGAGCGCTACTCTCGTAGATCCAGAAGAA
ACACATCGGCTTCTGATGAAGACGAGCGCATGTCAGTGGGTAGTCGTGGAAGCCTGAGGTCGCAGCCTGACTTGGAGTATGGGGGTCCTT
ACGCCTGGACAAATGGTTATGATGGAGAATTGTATGGATCACAGTCCCTGAATAGAAGATCTGGCAGGCCCTCCTGTCTGTACAGCGCTG
CCCGGCCTTCGGGGAGTTACCGGGCGTCTGTGTTGGATGAAGGCAGCTTCGGTGGGACCCGACGGGGCAGCACCTCCGGCTCCCGTGCTC
CCTCGGAGTACAGCGGCCACCTCAACTCCAGCTCCCGCGCCTCCTCCAGGGCCAGCTCGGCCCGGGCCAGCCCTGTGGTAGAAGAGAGAC
CAGAAAAAGATTTTACTGAGAAGGGGTCTCGTAACATGCCGGGCCTGTCTGCAGCCACGCTGGCCTCTCTGGGTGGGACTTCCTCTCGGA
GAGGCAGCGGAGACACCTCCATCTCCATCGACACCGAGGCATCCATCAGGGAAATCAAGGAACTCAATGAGTTAAAGGACCAGATTCAGG
ATGTAGAAGGCAAATACATGCAGGGATTGAAAGAGATGAAGGACTCTCTAGCAGAAGTTGAAGAGAAATATAAGAAGGCTATGGTTTCCA
ATGCTCAGCTAGACAATGAAAAGACAAACTTCATGTACCAGGTTGATACCCTAAAAGATATGTTGCTGGAGCTTGAAGAACAGCTGGCTG
AATCTAGGCGGCAGTACGAAGAGAAAAACAAAGAATTTGAAAGGGAAAAACACGCCCACAGTATACTGCAATTTCAGTTTGCTGAAGTCA
AGGAGGCCCTGAAGCAAAGAGAGGAAATGCTCGAGGAAATCCGACAGCTACAGCAGAAACAGGCGAGTTCTATCAGGGAGATTTCTGATC
TTCAGGAAACAATAGAGTGGAAAGACAAAAAGATAGGGGCATTAGAGAGGCAGAAAGAGTTCTTTGATTCCGTAAGGAGTGAACGGGATG
ATCTTAGAGAAGAAGTAGTCATGCTGAAAGAGGAATTAAAGAAACATGGAATAATCCTAAATTCAGAAATAGCTACCAATGGAGAGACTT
CCGACACCCTCAATAATGTTGGATACCAAGGTCCTACCAAGATGACAAAAGAAGAGTTAAATGCCCTCAAGTCGACAGGGGATGGGACCC
TAGATATTAGGTTGAAAAAGCTGGTTGATGAACGGGAATGCTTATTGGAACAGATTAAGAAACTCAAAGGGCAGCTGGAGGAGAGACAGA
AGATTGGCAAACTAGACAATCTTCGATCTGAAGATGATGTCTTGGAAAACGGGACAGACATGCATGTAATGGACCTACAAAGGGATGCCA
ACAGACAGATCAGCGACCTCAAATTTAAACTTGCAAAATCTGAGCAAGAGATAACTGCATTAGAACAAAATGTAATAAGGTTAGAGAGTC
AAGTATCACGTTACAAATCAGCGGCTGAAAATGCAGAAAAAATAGAAGATGAACTTAAGGCAGAAAAACGGAAACTCCAAAGAGAGCTCC
GCTCTGCATTGGATAAAACAGAAGAGCTCGAGGTGAGCAACGGCCACTTAGTGAAGCGTCTGGAAAAAATGAAAGCAAATCGGAGTGCAC
TCTTGTCCCAGCAGTAAATTCCAGCTCTGATCAGGCAACTGGTTGGTGACTGGAGAGCATTGTTTCATAGGCTTTTCTCTGTCCTATCTG
GGAGCGCTGCTTCTTCCCCTGCCTTCCGAGAGACGAAGACCGTGGCGAGCTTGGCGCTTAGGGGCTCCCGTGCCATGGCTCACCCCAGGG
AGCCCCAGCAGCCACCAGGTGCCTCTGTCTGCAGACCCCTGGCCCGGGCTGGCGCCGACGCTCAGAACCTGCAGGTACTTCATAAGCACA
CAGGGGCCTCGAGGGAGCTCTGTGTCTGACCGCACAGCAGCCTCTGAATGCCGCTGGAAGTGATGATCAAAGTAAAGATTCAGTTGGGAC
TTGAGTTTTTTTTTTTTTTCATGTGTCTTGCTGAAGATTAAGGGGAAATGTTACAGTGTTGGGACTTCCTTTCATGGCAGAATCTACAAT
TTGAGCGACTTCAGTAGTATCTCTTAGTCTACGCTTTTCATACACAAAACACTGTGGAACCACAAGCCATTACCAAGCAAAACTCTTTCA
CTGGAAACAAGGGGGCAGTCTAGAAGTAAAAGTGACCTTAAGAAGACTCTTTACAGGCAACAAATGAAGCTTTTCTAAGGGATTTTTGCA
TCAGTTCAGTCATAAGAATACTTTTTTCCAGGGTAATTAGGCAATAGCTTCACTGAAAATGACAGCTTTTCATTGCATTATTTAATCCTT

>22906_22906_1_DIS3L2-LRRFIP1_DIS3L2_chr2_232894790_ENST00000273009_LRRFIP1_chr2_238617186_ENST00000308482_length(amino acids)=742AA_BP=134
MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK
KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKAEARLAAKRAARAEAREIRMKELERQQKEIYQVQKKYYGLDTKWGD
IEQWMEDSERYSRRSRRNTSASDEDERMSVGSRGSLRSQPDLEYGGPYAWTNGYDGELYGSQSLNRRSGRPSCLYSAARPSGSYRASVLD
EGSFGGTRRGSTSGSRAPSEYSGHLNSSSRASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTE
ASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEF
EREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEEL
KKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDD
VLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVS

--------------------------------------------------------------
>22906_22906_2_DIS3L2-LRRFIP1_DIS3L2_chr2_232894790_ENST00000325385_LRRFIP1_chr2_238617186_ENST00000308482_length(transcript)=3252nt_BP=642nt
TTTCGCCCTTGTCGCAGCTGAACCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCAC
CGTCGCTCTCTAGAACGCCGCGCCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAA
ACGCGAATGACAACAGAGCTGCTCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAG
CCAATAATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATT
GGTGCTTCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGAT
GTTTCAGAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCG
GATGGTGATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAG
GAGCATTGGAAGGCGGAAGCCCGGCTCGCTGCAAAACGGGCGGCCCGCGCGGAGGCTCGCGAGATCCGCATGAAGGAGCTGGAGCGGCAG
CAGAAGGAGATCTATCAGGTCCAAAAGAAATATTATGGGCTGGATACAAAATGGGGTGACATCGAGCAGTGGATGGAAGACAGTGAGCGC
TACTCTCGTAGATCCAGAAGAAACACATCGGCTTCTGATGAAGACGAGCGCATGTCAGTGGGTAGTCGTGGAAGCCTGAGGTCGCAGCCT
GACTTGGAGTATGGGGGTCCTTACGCCTGGACAAATGGTTATGATGGAGAATTGTATGGATCACAGTCCCTGAATAGAAGATCTGGCAGG
CCCTCCTGTCTGTACAGCGCTGCCCGGCCTTCGGGGAGTTACCGGGCGTCTGTGTTGGATGAAGGCAGCTTCGGTGGGACCCGACGGGGC
AGCACCTCCGGCTCCCGTGCTCCCTCGGAGTACAGCGGCCACCTCAACTCCAGCTCCCGCGCCTCCTCCAGGGCCAGCTCGGCCCGGGCC
AGCCCTGTGGTAGAAGAGAGACCAGAAAAAGATTTTACTGAGAAGGGGTCTCGTAACATGCCGGGCCTGTCTGCAGCCACGCTGGCCTCT
CTGGGTGGGACTTCCTCTCGGAGAGGCAGCGGAGACACCTCCATCTCCATCGACACCGAGGCATCCATCAGGGAAATCAAGGAACTCAAT
GAGTTAAAGGACCAGATTCAGGATGTAGAAGGCAAATACATGCAGGGATTGAAAGAGATGAAGGACTCTCTAGCAGAAGTTGAAGAGAAA
TATAAGAAGGCTATGGTTTCCAATGCTCAGCTAGACAATGAAAAGACAAACTTCATGTACCAGGTTGATACCCTAAAAGATATGTTGCTG
GAGCTTGAAGAACAGCTGGCTGAATCTAGGCGGCAGTACGAAGAGAAAAACAAAGAATTTGAAAGGGAAAAACACGCCCACAGTATACTG
CAATTTCAGTTTGCTGAAGTCAAGGAGGCCCTGAAGCAAAGAGAGGAAATGCTCGAGGAAATCCGACAGCTACAGCAGAAACAGGCGAGT
TCTATCAGGGAGATTTCTGATCTTCAGGAAACAATAGAGTGGAAAGACAAAAAGATAGGGGCATTAGAGAGGCAGAAAGAGTTCTTTGAT
TCCGTAAGGAGTGAACGGGATGATCTTAGAGAAGAAGTAGTCATGCTGAAAGAGGAATTAAAGAAACATGGAATAATCCTAAATTCAGAA
ATAGCTACCAATGGAGAGACTTCCGACACCCTCAATAATGTTGGATACCAAGGTCCTACCAAGATGACAAAAGAAGAGTTAAATGCCCTC
AAGTCGACAGGGGATGGGACCCTAGATATTAGGTTGAAAAAGCTGGTTGATGAACGGGAATGCTTATTGGAACAGATTAAGAAACTCAAA
GGGCAGCTGGAGGAGAGACAGAAGATTGGCAAACTAGACAATCTTCGATCTGAAGATGATGTCTTGGAAAACGGGACAGACATGCATGTA
ATGGACCTACAAAGGGATGCCAACAGACAGATCAGCGACCTCAAATTTAAACTTGCAAAATCTGAGCAAGAGATAACTGCATTAGAACAA
AATGTAATAAGGTTAGAGAGTCAAGTATCACGTTACAAATCAGCGGCTGAAAATGCAGAAAAAATAGAAGATGAACTTAAGGCAGAAAAA
CGGAAACTCCAAAGAGAGCTCCGCTCTGCATTGGATAAAACAGAAGAGCTCGAGGTGAGCAACGGCCACTTAGTGAAGCGTCTGGAAAAA
ATGAAAGCAAATCGGAGTGCACTCTTGTCCCAGCAGTAAATTCCAGCTCTGATCAGGCAACTGGTTGGTGACTGGAGAGCATTGTTTCAT
AGGCTTTTCTCTGTCCTATCTGGGAGCGCTGCTTCTTCCCCTGCCTTCCGAGAGACGAAGACCGTGGCGAGCTTGGCGCTTAGGGGCTCC
CGTGCCATGGCTCACCCCAGGGAGCCCCAGCAGCCACCAGGTGCCTCTGTCTGCAGACCCCTGGCCCGGGCTGGCGCCGACGCTCAGAAC
CTGCAGGTACTTCATAAGCACACAGGGGCCTCGAGGGAGCTCTGTGTCTGACCGCACAGCAGCCTCTGAATGCCGCTGGAAGTGATGATC
AAAGTAAAGATTCAGTTGGGACTTGAGTTTTTTTTTTTTTTCATGTGTCTTGCTGAAGATTAAGGGGAAATGTTACAGTGTTGGGACTTC
CTTTCATGGCAGAATCTACAATTTGAGCGACTTCAGTAGTATCTCTTAGTCTACGCTTTTCATACACAAAACACTGTGGAACCACAAGCC
ATTACCAAGCAAAACTCTTTCACTGGAAACAAGGGGGCAGTCTAGAAGTAAAAGTGACCTTAAGAAGACTCTTTACAGGCAACAAATGAA
GCTTTTCTAAGGGATTTTTGCATCAGTTCAGTCATAAGAATACTTTTTTCCAGGGTAATTAGGCAATAGCTTCACTGAAAATGACAGCTT
TTCATTGCATTATTTAATCCTTATATTTGGAATTGAAGTCGTTAACTTCTTTTAAAGAATGTACTATTAGAAAAATTAAAAATGAAATGT

>22906_22906_2_DIS3L2-LRRFIP1_DIS3L2_chr2_232894790_ENST00000325385_LRRFIP1_chr2_238617186_ENST00000308482_length(amino acids)=742AA_BP=134
MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK
KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKAEARLAAKRAARAEAREIRMKELERQQKEIYQVQKKYYGLDTKWGD
IEQWMEDSERYSRRSRRNTSASDEDERMSVGSRGSLRSQPDLEYGGPYAWTNGYDGELYGSQSLNRRSGRPSCLYSAARPSGSYRASVLD
EGSFGGTRRGSTSGSRAPSEYSGHLNSSSRASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTE
ASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEF
EREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEEL
KKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDD
VLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVS

--------------------------------------------------------------
>22906_22906_3_DIS3L2-LRRFIP1_DIS3L2_chr2_232894790_ENST00000360410_LRRFIP1_chr2_238617186_ENST00000308482_length(transcript)=3252nt_BP=642nt
TTTCGCCCTTGTCGCAGCTGAACCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCAC
CGTCGCTCTCTAGAACGCCGCGCCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAA
ACGCGAATGACAACAGAGCTGCTCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAG
CCAATAATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATT
GGTGCTTCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGAT
GTTTCAGAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCG
GATGGTGATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAG
GAGCATTGGAAGGCGGAAGCCCGGCTCGCTGCAAAACGGGCGGCCCGCGCGGAGGCTCGCGAGATCCGCATGAAGGAGCTGGAGCGGCAG
CAGAAGGAGATCTATCAGGTCCAAAAGAAATATTATGGGCTGGATACAAAATGGGGTGACATCGAGCAGTGGATGGAAGACAGTGAGCGC
TACTCTCGTAGATCCAGAAGAAACACATCGGCTTCTGATGAAGACGAGCGCATGTCAGTGGGTAGTCGTGGAAGCCTGAGGTCGCAGCCT
GACTTGGAGTATGGGGGTCCTTACGCCTGGACAAATGGTTATGATGGAGAATTGTATGGATCACAGTCCCTGAATAGAAGATCTGGCAGG
CCCTCCTGTCTGTACAGCGCTGCCCGGCCTTCGGGGAGTTACCGGGCGTCTGTGTTGGATGAAGGCAGCTTCGGTGGGACCCGACGGGGC
AGCACCTCCGGCTCCCGTGCTCCCTCGGAGTACAGCGGCCACCTCAACTCCAGCTCCCGCGCCTCCTCCAGGGCCAGCTCGGCCCGGGCC
AGCCCTGTGGTAGAAGAGAGACCAGAAAAAGATTTTACTGAGAAGGGGTCTCGTAACATGCCGGGCCTGTCTGCAGCCACGCTGGCCTCT
CTGGGTGGGACTTCCTCTCGGAGAGGCAGCGGAGACACCTCCATCTCCATCGACACCGAGGCATCCATCAGGGAAATCAAGGAACTCAAT
GAGTTAAAGGACCAGATTCAGGATGTAGAAGGCAAATACATGCAGGGATTGAAAGAGATGAAGGACTCTCTAGCAGAAGTTGAAGAGAAA
TATAAGAAGGCTATGGTTTCCAATGCTCAGCTAGACAATGAAAAGACAAACTTCATGTACCAGGTTGATACCCTAAAAGATATGTTGCTG
GAGCTTGAAGAACAGCTGGCTGAATCTAGGCGGCAGTACGAAGAGAAAAACAAAGAATTTGAAAGGGAAAAACACGCCCACAGTATACTG
CAATTTCAGTTTGCTGAAGTCAAGGAGGCCCTGAAGCAAAGAGAGGAAATGCTCGAGGAAATCCGACAGCTACAGCAGAAACAGGCGAGT
TCTATCAGGGAGATTTCTGATCTTCAGGAAACAATAGAGTGGAAAGACAAAAAGATAGGGGCATTAGAGAGGCAGAAAGAGTTCTTTGAT
TCCGTAAGGAGTGAACGGGATGATCTTAGAGAAGAAGTAGTCATGCTGAAAGAGGAATTAAAGAAACATGGAATAATCCTAAATTCAGAA
ATAGCTACCAATGGAGAGACTTCCGACACCCTCAATAATGTTGGATACCAAGGTCCTACCAAGATGACAAAAGAAGAGTTAAATGCCCTC
AAGTCGACAGGGGATGGGACCCTAGATATTAGGTTGAAAAAGCTGGTTGATGAACGGGAATGCTTATTGGAACAGATTAAGAAACTCAAA
GGGCAGCTGGAGGAGAGACAGAAGATTGGCAAACTAGACAATCTTCGATCTGAAGATGATGTCTTGGAAAACGGGACAGACATGCATGTA
ATGGACCTACAAAGGGATGCCAACAGACAGATCAGCGACCTCAAATTTAAACTTGCAAAATCTGAGCAAGAGATAACTGCATTAGAACAA
AATGTAATAAGGTTAGAGAGTCAAGTATCACGTTACAAATCAGCGGCTGAAAATGCAGAAAAAATAGAAGATGAACTTAAGGCAGAAAAA
CGGAAACTCCAAAGAGAGCTCCGCTCTGCATTGGATAAAACAGAAGAGCTCGAGGTGAGCAACGGCCACTTAGTGAAGCGTCTGGAAAAA
ATGAAAGCAAATCGGAGTGCACTCTTGTCCCAGCAGTAAATTCCAGCTCTGATCAGGCAACTGGTTGGTGACTGGAGAGCATTGTTTCAT
AGGCTTTTCTCTGTCCTATCTGGGAGCGCTGCTTCTTCCCCTGCCTTCCGAGAGACGAAGACCGTGGCGAGCTTGGCGCTTAGGGGCTCC
CGTGCCATGGCTCACCCCAGGGAGCCCCAGCAGCCACCAGGTGCCTCTGTCTGCAGACCCCTGGCCCGGGCTGGCGCCGACGCTCAGAAC
CTGCAGGTACTTCATAAGCACACAGGGGCCTCGAGGGAGCTCTGTGTCTGACCGCACAGCAGCCTCTGAATGCCGCTGGAAGTGATGATC
AAAGTAAAGATTCAGTTGGGACTTGAGTTTTTTTTTTTTTTCATGTGTCTTGCTGAAGATTAAGGGGAAATGTTACAGTGTTGGGACTTC
CTTTCATGGCAGAATCTACAATTTGAGCGACTTCAGTAGTATCTCTTAGTCTACGCTTTTCATACACAAAACACTGTGGAACCACAAGCC
ATTACCAAGCAAAACTCTTTCACTGGAAACAAGGGGGCAGTCTAGAAGTAAAAGTGACCTTAAGAAGACTCTTTACAGGCAACAAATGAA
GCTTTTCTAAGGGATTTTTGCATCAGTTCAGTCATAAGAATACTTTTTTCCAGGGTAATTAGGCAATAGCTTCACTGAAAATGACAGCTT
TTCATTGCATTATTTAATCCTTATATTTGGAATTGAAGTCGTTAACTTCTTTTAAAGAATGTACTATTAGAAAAATTAAAAATGAAATGT

>22906_22906_3_DIS3L2-LRRFIP1_DIS3L2_chr2_232894790_ENST00000360410_LRRFIP1_chr2_238617186_ENST00000308482_length(amino acids)=742AA_BP=134
MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK
KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKAEARLAAKRAARAEAREIRMKELERQQKEIYQVQKKYYGLDTKWGD
IEQWMEDSERYSRRSRRNTSASDEDERMSVGSRGSLRSQPDLEYGGPYAWTNGYDGELYGSQSLNRRSGRPSCLYSAARPSGSYRASVLD
EGSFGGTRRGSTSGSRAPSEYSGHLNSSSRASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTE
ASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEF
EREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEEL
KKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDD
VLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVS

--------------------------------------------------------------
>22906_22906_4_DIS3L2-LRRFIP1_DIS3L2_chr2_232894790_ENST00000409307_LRRFIP1_chr2_238617186_ENST00000308482_length(transcript)=2976nt_BP=366nt
ATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCT
TCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCA
GAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGT
GATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCAT
TGGAAGGCGGAAGCCCGGCTCGCTGCAAAACGGGCGGCCCGCGCGGAGGCTCGCGAGATCCGCATGAAGGAGCTGGAGCGGCAGCAGAAG
GAGATCTATCAGGTCCAAAAGAAATATTATGGGCTGGATACAAAATGGGGTGACATCGAGCAGTGGATGGAAGACAGTGAGCGCTACTCT
CGTAGATCCAGAAGAAACACATCGGCTTCTGATGAAGACGAGCGCATGTCAGTGGGTAGTCGTGGAAGCCTGAGGTCGCAGCCTGACTTG
GAGTATGGGGGTCCTTACGCCTGGACAAATGGTTATGATGGAGAATTGTATGGATCACAGTCCCTGAATAGAAGATCTGGCAGGCCCTCC
TGTCTGTACAGCGCTGCCCGGCCTTCGGGGAGTTACCGGGCGTCTGTGTTGGATGAAGGCAGCTTCGGTGGGACCCGACGGGGCAGCACC
TCCGGCTCCCGTGCTCCCTCGGAGTACAGCGGCCACCTCAACTCCAGCTCCCGCGCCTCCTCCAGGGCCAGCTCGGCCCGGGCCAGCCCT
GTGGTAGAAGAGAGACCAGAAAAAGATTTTACTGAGAAGGGGTCTCGTAACATGCCGGGCCTGTCTGCAGCCACGCTGGCCTCTCTGGGT
GGGACTTCCTCTCGGAGAGGCAGCGGAGACACCTCCATCTCCATCGACACCGAGGCATCCATCAGGGAAATCAAGGAACTCAATGAGTTA
AAGGACCAGATTCAGGATGTAGAAGGCAAATACATGCAGGGATTGAAAGAGATGAAGGACTCTCTAGCAGAAGTTGAAGAGAAATATAAG
AAGGCTATGGTTTCCAATGCTCAGCTAGACAATGAAAAGACAAACTTCATGTACCAGGTTGATACCCTAAAAGATATGTTGCTGGAGCTT
GAAGAACAGCTGGCTGAATCTAGGCGGCAGTACGAAGAGAAAAACAAAGAATTTGAAAGGGAAAAACACGCCCACAGTATACTGCAATTT
CAGTTTGCTGAAGTCAAGGAGGCCCTGAAGCAAAGAGAGGAAATGCTCGAGGAAATCCGACAGCTACAGCAGAAACAGGCGAGTTCTATC
AGGGAGATTTCTGATCTTCAGGAAACAATAGAGTGGAAAGACAAAAAGATAGGGGCATTAGAGAGGCAGAAAGAGTTCTTTGATTCCGTA
AGGAGTGAACGGGATGATCTTAGAGAAGAAGTAGTCATGCTGAAAGAGGAATTAAAGAAACATGGAATAATCCTAAATTCAGAAATAGCT
ACCAATGGAGAGACTTCCGACACCCTCAATAATGTTGGATACCAAGGTCCTACCAAGATGACAAAAGAAGAGTTAAATGCCCTCAAGTCG
ACAGGGGATGGGACCCTAGATATTAGGTTGAAAAAGCTGGTTGATGAACGGGAATGCTTATTGGAACAGATTAAGAAACTCAAAGGGCAG
CTGGAGGAGAGACAGAAGATTGGCAAACTAGACAATCTTCGATCTGAAGATGATGTCTTGGAAAACGGGACAGACATGCATGTAATGGAC
CTACAAAGGGATGCCAACAGACAGATCAGCGACCTCAAATTTAAACTTGCAAAATCTGAGCAAGAGATAACTGCATTAGAACAAAATGTA
ATAAGGTTAGAGAGTCAAGTATCACGTTACAAATCAGCGGCTGAAAATGCAGAAAAAATAGAAGATGAACTTAAGGCAGAAAAACGGAAA
CTCCAAAGAGAGCTCCGCTCTGCATTGGATAAAACAGAAGAGCTCGAGGTGAGCAACGGCCACTTAGTGAAGCGTCTGGAAAAAATGAAA
GCAAATCGGAGTGCACTCTTGTCCCAGCAGTAAATTCCAGCTCTGATCAGGCAACTGGTTGGTGACTGGAGAGCATTGTTTCATAGGCTT
TTCTCTGTCCTATCTGGGAGCGCTGCTTCTTCCCCTGCCTTCCGAGAGACGAAGACCGTGGCGAGCTTGGCGCTTAGGGGCTCCCGTGCC
ATGGCTCACCCCAGGGAGCCCCAGCAGCCACCAGGTGCCTCTGTCTGCAGACCCCTGGCCCGGGCTGGCGCCGACGCTCAGAACCTGCAG
GTACTTCATAAGCACACAGGGGCCTCGAGGGAGCTCTGTGTCTGACCGCACAGCAGCCTCTGAATGCCGCTGGAAGTGATGATCAAAGTA
AAGATTCAGTTGGGACTTGAGTTTTTTTTTTTTTTCATGTGTCTTGCTGAAGATTAAGGGGAAATGTTACAGTGTTGGGACTTCCTTTCA
TGGCAGAATCTACAATTTGAGCGACTTCAGTAGTATCTCTTAGTCTACGCTTTTCATACACAAAACACTGTGGAACCACAAGCCATTACC
AAGCAAAACTCTTTCACTGGAAACAAGGGGGCAGTCTAGAAGTAAAAGTGACCTTAAGAAGACTCTTTACAGGCAACAAATGAAGCTTTT
CTAAGGGATTTTTGCATCAGTTCAGTCATAAGAATACTTTTTTCCAGGGTAATTAGGCAATAGCTTCACTGAAAATGACAGCTTTTCATT
GCATTATTTAATCCTTATATTTGGAATTGAAGTCGTTAACTTCTTTTAAAGAATGTACTATTAGAAAAATTAAAAATGAAATGTTGAGAG

>22906_22906_4_DIS3L2-LRRFIP1_DIS3L2_chr2_232894790_ENST00000409307_LRRFIP1_chr2_238617186_ENST00000308482_length(amino acids)=730AA_BP=122
MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG
DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKAEARLAAKRAARAEAREIRMKELERQQKEIYQVQKKYYGLDTKWGDIEQWMEDSERYS
RRSRRNTSASDEDERMSVGSRGSLRSQPDLEYGGPYAWTNGYDGELYGSQSLNRRSGRPSCLYSAARPSGSYRASVLDEGSFGGTRRGST
SGSRAPSEYSGHLNSSSRASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNEL
KDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQF
QFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIA
TNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMD
LQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMK

--------------------------------------------------------------
>22906_22906_5_DIS3L2-LRRFIP1_DIS3L2_chr2_232894790_ENST00000409401_LRRFIP1_chr2_238617186_ENST00000308482_length(transcript)=3151nt_BP=541nt
AGAACGCCGCGCCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAAACGCGAATGAC
AACAGAGCTGCTCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAGCCAATAATGAG
CCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCTTCGCC
AGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCAGAAGG
CTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGTGATCG
AGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCATTGGAA
GGCGGAAGCCCGGCTCGCTGCAAAACGGGCGGCCCGCGCGGAGGCTCGCGAGATCCGCATGAAGGAGCTGGAGCGGCAGCAGAAGGAGAT
CTATCAGGTCCAAAAGAAATATTATGGGCTGGATACAAAATGGGGTGACATCGAGCAGTGGATGGAAGACAGTGAGCGCTACTCTCGTAG
ATCCAGAAGAAACACATCGGCTTCTGATGAAGACGAGCGCATGTCAGTGGGTAGTCGTGGAAGCCTGAGGTCGCAGCCTGACTTGGAGTA
TGGGGGTCCTTACGCCTGGACAAATGGTTATGATGGAGAATTGTATGGATCACAGTCCCTGAATAGAAGATCTGGCAGGCCCTCCTGTCT
GTACAGCGCTGCCCGGCCTTCGGGGAGTTACCGGGCGTCTGTGTTGGATGAAGGCAGCTTCGGTGGGACCCGACGGGGCAGCACCTCCGG
CTCCCGTGCTCCCTCGGAGTACAGCGGCCACCTCAACTCCAGCTCCCGCGCCTCCTCCAGGGCCAGCTCGGCCCGGGCCAGCCCTGTGGT
AGAAGAGAGACCAGAAAAAGATTTTACTGAGAAGGGGTCTCGTAACATGCCGGGCCTGTCTGCAGCCACGCTGGCCTCTCTGGGTGGGAC
TTCCTCTCGGAGAGGCAGCGGAGACACCTCCATCTCCATCGACACCGAGGCATCCATCAGGGAAATCAAGGAACTCAATGAGTTAAAGGA
CCAGATTCAGGATGTAGAAGGCAAATACATGCAGGGATTGAAAGAGATGAAGGACTCTCTAGCAGAAGTTGAAGAGAAATATAAGAAGGC
TATGGTTTCCAATGCTCAGCTAGACAATGAAAAGACAAACTTCATGTACCAGGTTGATACCCTAAAAGATATGTTGCTGGAGCTTGAAGA
ACAGCTGGCTGAATCTAGGCGGCAGTACGAAGAGAAAAACAAAGAATTTGAAAGGGAAAAACACGCCCACAGTATACTGCAATTTCAGTT
TGCTGAAGTCAAGGAGGCCCTGAAGCAAAGAGAGGAAATGCTCGAGGAAATCCGACAGCTACAGCAGAAACAGGCGAGTTCTATCAGGGA
GATTTCTGATCTTCAGGAAACAATAGAGTGGAAAGACAAAAAGATAGGGGCATTAGAGAGGCAGAAAGAGTTCTTTGATTCCGTAAGGAG
TGAACGGGATGATCTTAGAGAAGAAGTAGTCATGCTGAAAGAGGAATTAAAGAAACATGGAATAATCCTAAATTCAGAAATAGCTACCAA
TGGAGAGACTTCCGACACCCTCAATAATGTTGGATACCAAGGTCCTACCAAGATGACAAAAGAAGAGTTAAATGCCCTCAAGTCGACAGG
GGATGGGACCCTAGATATTAGGTTGAAAAAGCTGGTTGATGAACGGGAATGCTTATTGGAACAGATTAAGAAACTCAAAGGGCAGCTGGA
GGAGAGACAGAAGATTGGCAAACTAGACAATCTTCGATCTGAAGATGATGTCTTGGAAAACGGGACAGACATGCATGTAATGGACCTACA
AAGGGATGCCAACAGACAGATCAGCGACCTCAAATTTAAACTTGCAAAATCTGAGCAAGAGATAACTGCATTAGAACAAAATGTAATAAG
GTTAGAGAGTCAAGTATCACGTTACAAATCAGCGGCTGAAAATGCAGAAAAAATAGAAGATGAACTTAAGGCAGAAAAACGGAAACTCCA
AAGAGAGCTCCGCTCTGCATTGGATAAAACAGAAGAGCTCGAGGTGAGCAACGGCCACTTAGTGAAGCGTCTGGAAAAAATGAAAGCAAA
TCGGAGTGCACTCTTGTCCCAGCAGTAAATTCCAGCTCTGATCAGGCAACTGGTTGGTGACTGGAGAGCATTGTTTCATAGGCTTTTCTC
TGTCCTATCTGGGAGCGCTGCTTCTTCCCCTGCCTTCCGAGAGACGAAGACCGTGGCGAGCTTGGCGCTTAGGGGCTCCCGTGCCATGGC
TCACCCCAGGGAGCCCCAGCAGCCACCAGGTGCCTCTGTCTGCAGACCCCTGGCCCGGGCTGGCGCCGACGCTCAGAACCTGCAGGTACT
TCATAAGCACACAGGGGCCTCGAGGGAGCTCTGTGTCTGACCGCACAGCAGCCTCTGAATGCCGCTGGAAGTGATGATCAAAGTAAAGAT
TCAGTTGGGACTTGAGTTTTTTTTTTTTTTCATGTGTCTTGCTGAAGATTAAGGGGAAATGTTACAGTGTTGGGACTTCCTTTCATGGCA
GAATCTACAATTTGAGCGACTTCAGTAGTATCTCTTAGTCTACGCTTTTCATACACAAAACACTGTGGAACCACAAGCCATTACCAAGCA
AAACTCTTTCACTGGAAACAAGGGGGCAGTCTAGAAGTAAAAGTGACCTTAAGAAGACTCTTTACAGGCAACAAATGAAGCTTTTCTAAG
GGATTTTTGCATCAGTTCAGTCATAAGAATACTTTTTTCCAGGGTAATTAGGCAATAGCTTCACTGAAAATGACAGCTTTTCATTGCATT
ATTTAATCCTTATATTTGGAATTGAAGTCGTTAACTTCTTTTAAAGAATGTACTATTAGAAAAATTAAAAATGAAATGTTGAGAGACTTC

>22906_22906_5_DIS3L2-LRRFIP1_DIS3L2_chr2_232894790_ENST00000409401_LRRFIP1_chr2_238617186_ENST00000308482_length(amino acids)=742AA_BP=134
MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK
KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKAEARLAAKRAARAEAREIRMKELERQQKEIYQVQKKYYGLDTKWGD
IEQWMEDSERYSRRSRRNTSASDEDERMSVGSRGSLRSQPDLEYGGPYAWTNGYDGELYGSQSLNRRSGRPSCLYSAARPSGSYRASVLD
EGSFGGTRRGSTSGSRAPSEYSGHLNSSSRASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTE
ASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEF
EREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEEL
KKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDD
VLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DIS3L2-LRRFIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DIS3L2-LRRFIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for DIS3L2-LRRFIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource