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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DIS3L2-SPATA3 (FusionGDB2 ID:22913)

Fusion Gene Summary for DIS3L2-SPATA3

check button Fusion gene summary
Fusion gene informationFusion gene name: DIS3L2-SPATA3
Fusion gene ID: 22913
HgeneTgene
Gene symbol

DIS3L2

SPATA3

Gene ID

129563

130560

Gene nameDIS3 like 3'-5' exoribonuclease 2spermatogenesis associated 3
SynonymsFAM6A|PRLMNS|hDIS3L2TSARG1
Cytomap

2q37.1

2q37.1

Type of geneprotein-codingprotein-coding
DescriptionDIS3-like exonuclease 2DIS3 mitotic control homolog-like 2family with sequence similarity 6, member Aspermatogenesis-associated protein 3testis and spermatogenesis cell apoptosis related gene 1testis and spermatogenesis cell-related protein 1testis spermatocyte apoptosis-related protein 1
Modification date2020031320200313
UniProtAcc

Q8IYB7

Q96N06

Ensembl transtripts involved in fusion geneENST00000273009, ENST00000325385, 
ENST00000409307, ENST00000360410, 
ENST00000409401, ENST00000470087, 
ENST00000409956, ENST00000424440, 
ENST00000433428, ENST00000452881, 
ENST00000455816, 
Fusion gene scores* DoF score27 X 9 X 12=29162 X 2 X 2=8
# samples 252
** MAII scorelog2(25/2916*10)=-3.54399071966485
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: DIS3L2 [Title/Abstract] AND SPATA3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDIS3L2(233075115)-SPATA3(231865080), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDIS3L2

GO:0010587

miRNA catabolic process

24141620


check buttonFusion gene breakpoints across DIS3L2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SPATA3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-JY-A6FHDIS3L2chr2

233075115

+SPATA3chr2

231865080

+


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Fusion Gene ORF analysis for DIS3L2-SPATA3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000273009ENST00000409956DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
5CDS-intronENST00000325385ENST00000409956DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
5CDS-intronENST00000409307ENST00000409956DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
In-frameENST00000273009ENST00000424440DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
In-frameENST00000273009ENST00000433428DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
In-frameENST00000273009ENST00000452881DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
In-frameENST00000273009ENST00000455816DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
In-frameENST00000325385ENST00000424440DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
In-frameENST00000325385ENST00000433428DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
In-frameENST00000325385ENST00000452881DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
In-frameENST00000325385ENST00000455816DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
In-frameENST00000409307ENST00000424440DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
In-frameENST00000409307ENST00000433428DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
In-frameENST00000409307ENST00000452881DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
In-frameENST00000409307ENST00000455816DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
intron-3CDSENST00000360410ENST00000424440DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
intron-3CDSENST00000360410ENST00000433428DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
intron-3CDSENST00000360410ENST00000452881DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
intron-3CDSENST00000360410ENST00000455816DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
intron-3CDSENST00000409401ENST00000424440DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
intron-3CDSENST00000409401ENST00000433428DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
intron-3CDSENST00000409401ENST00000452881DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
intron-3CDSENST00000409401ENST00000455816DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
intron-3CDSENST00000470087ENST00000424440DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
intron-3CDSENST00000470087ENST00000433428DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
intron-3CDSENST00000470087ENST00000452881DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
intron-3CDSENST00000470087ENST00000455816DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
intron-intronENST00000360410ENST00000409956DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
intron-intronENST00000409401ENST00000409956DIS3L2chr2

233075115

+SPATA3chr2

231865080

+
intron-intronENST00000470087ENST00000409956DIS3L2chr2

233075115

+SPATA3chr2

231865080

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000273009DIS3L2chr2233075115+ENST00000424440SPATA3chr2231865080+241518185782095505
ENST00000273009DIS3L2chr2233075115+ENST00000452881SPATA3chr2231865080+302718185782095505
ENST00000273009DIS3L2chr2233075115+ENST00000433428SPATA3chr2231865080+227718185782095505
ENST00000273009DIS3L2chr2233075115+ENST00000455816SPATA3chr2231865080+228318185782095505
ENST00000325385DIS3L2chr2233075115+ENST00000424440SPATA3chr2231865080+207714802401757505
ENST00000325385DIS3L2chr2233075115+ENST00000452881SPATA3chr2231865080+268914802401757505
ENST00000325385DIS3L2chr2233075115+ENST00000433428SPATA3chr2231865080+193914802401757505
ENST00000325385DIS3L2chr2233075115+ENST00000455816SPATA3chr2231865080+194514802401757505
ENST00000409307DIS3L2chr2233075115+ENST00000424440SPATA3chr2231865080+1801120401481493
ENST00000409307DIS3L2chr2233075115+ENST00000452881SPATA3chr2231865080+2413120401481493
ENST00000409307DIS3L2chr2233075115+ENST00000433428SPATA3chr2231865080+1663120401481493
ENST00000409307DIS3L2chr2233075115+ENST00000455816SPATA3chr2231865080+1669120401481493

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000273009ENST00000424440DIS3L2chr2233075115+SPATA3chr2231865080+0.0051119420.9948881
ENST00000273009ENST00000452881DIS3L2chr2233075115+SPATA3chr2231865080+0.0041172230.99588275
ENST00000273009ENST00000433428DIS3L2chr2233075115+SPATA3chr2231865080+0.0057041010.9942959
ENST00000273009ENST00000455816DIS3L2chr2233075115+SPATA3chr2231865080+0.00652910.9934709
ENST00000325385ENST00000424440DIS3L2chr2233075115+SPATA3chr2231865080+0.0039430930.9960569
ENST00000325385ENST00000452881DIS3L2chr2233075115+SPATA3chr2231865080+0.0031934910.9968065
ENST00000325385ENST00000433428DIS3L2chr2233075115+SPATA3chr2231865080+0.0044150880.99558485
ENST00000325385ENST00000455816DIS3L2chr2233075115+SPATA3chr2231865080+0.0051522420.9948478
ENST00000409307ENST00000424440DIS3L2chr2233075115+SPATA3chr2231865080+0.001792020.9982079
ENST00000409307ENST00000452881DIS3L2chr2233075115+SPATA3chr2231865080+0.0019003470.9980996
ENST00000409307ENST00000433428DIS3L2chr2233075115+SPATA3chr2231865080+0.0019786020.99802136
ENST00000409307ENST00000455816DIS3L2chr2233075115+SPATA3chr2231865080+0.0024041650.99759585

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Fusion Genomic Features for DIS3L2-SPATA3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DIS3L2chr2233075115+SPATA3chr2231865080+0.0031718650.99682814
DIS3L2chr2233075115+SPATA3chr2231865080+0.0031718650.99682814

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DIS3L2-SPATA3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:233075115/chr2:231865080)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DIS3L2

Q8IYB7

SPATA3

Q96N06

FUNCTION: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. {ECO:0000255|HAMAP-Rule:MF_03045, ECO:0000269|PubMed:23756462, ECO:0000269|PubMed:24141620}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DIS3L2-SPATA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22913_22913_1_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000273009_SPATA3_chr2_231865080_ENST00000424440_length(transcript)=2415nt_BP=1818nt
ATGCGGGGGTTGTCCATCTCTGTATCCCCAGTGCCAGCACTGCACCTCGCCCCAAGCAGTTGTCCAATAAATGAGCAGTGAGTAAATGAA
AGAATGAGCAAAGCCTTGTAACAGGAAAGGGGCCGGCGGCGTCTGCCGTGCAAGACCTGGCCCAGTGGAGCAGAGCCTGGAGGTTCAGGA
GCCGGGTCTGGAAGGCTCCTTCCGGTGGAAGAGGGGCCCGGAGCCAGCCGGCGCCTGGCACAAGGCGTCTCAGAGGCCGCCCACTGGGAG
CCAACCGTTGCAGCCAGTTGTCCCCGCGAGCGAGGCCGGAGAAGGCGCGGCGGCCCCTGGCCTGGCCATTTCGCCCTTGTCGCAGCTGAA
CCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCACCGTCGCTCTCTAGAACGCCGCG
CCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAAACGCGAATGACAACAGAGCTGC
TCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAGCCAATAATGAGCCATCCTGACT
ACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCTTCGCCAGGTGACAAAA
AGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCAGAAGGCTTGAAGAGAG
GAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGTGATCGAGACATTTTTA
TTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCATTGGAAGGTAGTTAAAC
CAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTCCCGCAACAGTCCCTGA
AAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGCATCACACAAAATGTGC
TGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACAAAAGATGAGACCACCT
GCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAGAAAAAACATTCTCGAG
CAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCCTCAGACCACCGAGTGC
CTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTGTTCATCTGCCGCATTG
TGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAGCCTGAAACAGAAGGAA
TACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCATGGACAATTCCACCAG
AGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGAGACCTCGATGATGCCCTCTCCT
GCAAGCCACTCGCTGACGGGCCTCTGATTCGCGCCGGCCCGCATTCCTGCTCCTGTGCCACTTGCCCCTGCAGCTCCGCTTGCTGGCGTC
GTCTGGGGCTATGCCATAGCCGCATCTTCGATGTCCTTCTGCCTCGGGACTGGCAGATGGCGCCAGGGAGAGGACTCCCCAACCTGCTCA
CCTTCTACAGAAAATCTTCAAGAAAACCCTCCAGTCATCGTAACGCGTGTCCTCCAAGCCCTCGGAACTGTGGCTGTGGCTCTGGGGGCT
CTAGGAGCTGCCTACTACATCACTGAATCCTTGTGAACAAGCCCCTAGGCCCACAGTCTGGCAGACCTCCACCAGCCCCAGGAGTTGATA
GGTGATGGCGCTGGGAGAAGATGTTCAGAATATCTCAAAAGCCAAGTCCAGAAGTTTGATGTCCTTCCCTGTCCAGAGAGTGAAGAACCA
TCTGACGACAGTGACATCTTTCCTTTTTGGGGAAAGATGCTTCTAGAATTTTCTTTCCTAAAGTTTGGTGAACCTCTCCCTTGGCATCTT

>22913_22913_1_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000273009_SPATA3_chr2_231865080_ENST00000424440_length(amino acids)=505AA_BP=413
MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK
KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA
QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN
SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS
SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGPLIRAGPHSCSCATCPCSSACWRRLGLCHSRIFDVL

--------------------------------------------------------------
>22913_22913_2_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000273009_SPATA3_chr2_231865080_ENST00000433428_length(transcript)=2277nt_BP=1818nt
ATGCGGGGGTTGTCCATCTCTGTATCCCCAGTGCCAGCACTGCACCTCGCCCCAAGCAGTTGTCCAATAAATGAGCAGTGAGTAAATGAA
AGAATGAGCAAAGCCTTGTAACAGGAAAGGGGCCGGCGGCGTCTGCCGTGCAAGACCTGGCCCAGTGGAGCAGAGCCTGGAGGTTCAGGA
GCCGGGTCTGGAAGGCTCCTTCCGGTGGAAGAGGGGCCCGGAGCCAGCCGGCGCCTGGCACAAGGCGTCTCAGAGGCCGCCCACTGGGAG
CCAACCGTTGCAGCCAGTTGTCCCCGCGAGCGAGGCCGGAGAAGGCGCGGCGGCCCCTGGCCTGGCCATTTCGCCCTTGTCGCAGCTGAA
CCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCACCGTCGCTCTCTAGAACGCCGCG
CCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAAACGCGAATGACAACAGAGCTGC
TCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAGCCAATAATGAGCCATCCTGACT
ACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCTTCGCCAGGTGACAAAA
AGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCAGAAGGCTTGAAGAGAG
GAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGTGATCGAGACATTTTTA
TTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCATTGGAAGGTAGTTAAAC
CAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTCCCGCAACAGTCCCTGA
AAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGCATCACACAAAATGTGC
TGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACAAAAGATGAGACCACCT
GCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAGAAAAAACATTCTCGAG
CAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCCTCAGACCACCGAGTGC
CTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTGTTCATCTGCCGCATTG
TGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAGCCTGAAACAGAAGGAA
TACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCATGGACAATTCCACCAG
AGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGAGACCTCGATGATGCCCTCTCCT
GCAAGCCACTCGCTGACGGGCCTCTGATTCGCGCCGGCCCGCATTCCTGCTCCTGTGCCACTTGCCCCTGCAGCTCCGCTTGCTGGCGTC
GTCTGGGGCTATGCCATAGCCGCATCTTCGATGTCCTTCTGCCTCGGGACTGGCAGATGGCGCCAGGGAGAGGACTCCCCAACCTGCTCA
CCTTCTACAGAAAATCTTCAAGAAAACCCTCCAGTCATCGTAACGCGTGTCCTCCAAGCCCTCGGAACTGTGGCTGTGGCTCTGGGGGCT
CTAGGAGCTGCCTACTACATCACTGAATCCTTGTGAACAAGCCCCTAGGCCCACAGTCTGGCAGACCTCCACCAGCCCCAGGAGTTGATA
GGTGATGGCGCTGGGAGAAGATGTTCAGAATATCTCAAAAGCCAAGTCCAGAAGATCCAGTTTCCATCAAAGGGACCTCTCTTGTCACCA

>22913_22913_2_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000273009_SPATA3_chr2_231865080_ENST00000433428_length(amino acids)=505AA_BP=413
MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK
KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA
QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN
SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS
SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGPLIRAGPHSCSCATCPCSSACWRRLGLCHSRIFDVL

--------------------------------------------------------------
>22913_22913_3_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000273009_SPATA3_chr2_231865080_ENST00000452881_length(transcript)=3027nt_BP=1818nt
ATGCGGGGGTTGTCCATCTCTGTATCCCCAGTGCCAGCACTGCACCTCGCCCCAAGCAGTTGTCCAATAAATGAGCAGTGAGTAAATGAA
AGAATGAGCAAAGCCTTGTAACAGGAAAGGGGCCGGCGGCGTCTGCCGTGCAAGACCTGGCCCAGTGGAGCAGAGCCTGGAGGTTCAGGA
GCCGGGTCTGGAAGGCTCCTTCCGGTGGAAGAGGGGCCCGGAGCCAGCCGGCGCCTGGCACAAGGCGTCTCAGAGGCCGCCCACTGGGAG
CCAACCGTTGCAGCCAGTTGTCCCCGCGAGCGAGGCCGGAGAAGGCGCGGCGGCCCCTGGCCTGGCCATTTCGCCCTTGTCGCAGCTGAA
CCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCACCGTCGCTCTCTAGAACGCCGCG
CCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAAACGCGAATGACAACAGAGCTGC
TCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAGCCAATAATGAGCCATCCTGACT
ACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCTTCGCCAGGTGACAAAA
AGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCAGAAGGCTTGAAGAGAG
GAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGTGATCGAGACATTTTTA
TTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCATTGGAAGGTAGTTAAAC
CAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTCCCGCAACAGTCCCTGA
AAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGCATCACACAAAATGTGC
TGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACAAAAGATGAGACCACCT
GCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAGAAAAAACATTCTCGAG
CAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCCTCAGACCACCGAGTGC
CTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTGTTCATCTGCCGCATTG
TGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAGCCTGAAACAGAAGGAA
TACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCATGGACAATTCCACCAG
AGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGAGACCTCGATGATGCCCTCTCCT
GCAAGCCACTCGCTGACGGGCCTCTGATTCGCGCCGGCCCGCATTCCTGCTCCTGTGCCACTTGCCCCTGCAGCTCCGCTTGCTGGCGTC
GTCTGGGGCTATGCCATAGCCGCATCTTCGATGTCCTTCTGCCTCGGGACTGGCAGATGGCGCCAGGGAGAGGACTCCCCAACCTGCTCA
CCTTCTACAGAAAATCTTCAAGAAAACCCTCCAGTCATCGTAACGCGTGTCCTCCAAGCCCTCGGAACTGTGGCTGTGGCTCTGGGGGCT
CTAGGAGCTGCCTACTACATCACTGAATCCTTGTGAACAAGCCCCTAGGCCCACAGTCTGGCAGACCTCCACCAGCCCCAGGAGTTGATA
GGTGATGGCGCTGGGAGAAGATGTTCAGAATATCTCAAAAGCCAAGTCCAGAAGGAGGTGCTTTTAATGTGCTGATAAACCAACCTCAGG
AAGGTATTATGTACAGAAGATTCCCAAGGCTGCTGTTGCTGAAAGAGACTTGGGCTACTGCCAGGGAACTAGGGTCTCACTCTGTCACCC
AGGTTGGAGTGCAGCAGGGGCATGATCAGCTCACTGAAGGATCATTTCTTGGTCTAGGCTATAGGCTGGCCTTAGAATCAACTCACCTGG
TGTCCTATTGTCAGGGACATCTTAACCAGGGTGACTGCACCTCGAATAAAGGCCAGATAAAGCCAAACTTGCTGGGTTACATTCCTTGGG
GGTTAGACACCCTTCATCACAAGATGTTTGTAGCTCAAAGAAGGGGTTAATGATGCTAACTAGAGACCCAGAACGTCTGAAAACGTCCTG
ATATTTAAAGAACAAAGCATCCTTCATTTGAGAATAAGTTTCACTTTAAAGACCCCCTCAATATCCTCCTCAGATTTGCCCTGCACTTCT
TGTTCCATGCTTGGGGTCCTAAGAACAAGCCATCTGATGCCTCTACTATCATTACCTCTATTGGGACCCAGAAACCAATACCCCAAAATA
TGGTGCATGGACATGCTGAACTGAAGAAGATGCCTCAAGGGTCATCCCTAAAGGCAAAAACAGAACTTCCAAAGTATCTTTCTGTGACAA
CATTAGGTTCAGGCTTGAAGTCCCTGATTTCGCCATCAAAGTCAGATCCAGGGGGGACGATGCTATTCAGAAACGTGCTGAGAAGAGGAC

>22913_22913_3_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000273009_SPATA3_chr2_231865080_ENST00000452881_length(amino acids)=505AA_BP=413
MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK
KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA
QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN
SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS
SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGPLIRAGPHSCSCATCPCSSACWRRLGLCHSRIFDVL

--------------------------------------------------------------
>22913_22913_4_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000273009_SPATA3_chr2_231865080_ENST00000455816_length(transcript)=2283nt_BP=1818nt
ATGCGGGGGTTGTCCATCTCTGTATCCCCAGTGCCAGCACTGCACCTCGCCCCAAGCAGTTGTCCAATAAATGAGCAGTGAGTAAATGAA
AGAATGAGCAAAGCCTTGTAACAGGAAAGGGGCCGGCGGCGTCTGCCGTGCAAGACCTGGCCCAGTGGAGCAGAGCCTGGAGGTTCAGGA
GCCGGGTCTGGAAGGCTCCTTCCGGTGGAAGAGGGGCCCGGAGCCAGCCGGCGCCTGGCACAAGGCGTCTCAGAGGCCGCCCACTGGGAG
CCAACCGTTGCAGCCAGTTGTCCCCGCGAGCGAGGCCGGAGAAGGCGCGGCGGCCCCTGGCCTGGCCATTTCGCCCTTGTCGCAGCTGAA
CCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCACCGTCGCTCTCTAGAACGCCGCG
CCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAAACGCGAATGACAACAGAGCTGC
TCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAGCCAATAATGAGCCATCCTGACT
ACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCTTCGCCAGGTGACAAAA
AGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCAGAAGGCTTGAAGAGAG
GAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGTGATCGAGACATTTTTA
TTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCATTGGAAGGTAGTTAAAC
CAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTCCCGCAACAGTCCCTGA
AAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGCATCACACAAAATGTGC
TGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACAAAAGATGAGACCACCT
GCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAGAAAAAACATTCTCGAG
CAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCCTCAGACCACCGAGTGC
CTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTGTTCATCTGCCGCATTG
TGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAGCCTGAAACAGAAGGAA
TACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCATGGACAATTCCACCAG
AGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGAGACCTCGATGATGCCCTCTCCT
GCAAGCCACTCGCTGACGGGCCTCTGATTCGCGCCGGCCCGCATTCCTGCTCCTGTGCCACTTGCCCCTGCAGCTCCGCTTGCTGGCGTC
GTCTGGGGCTATGCCATAGCCGCATCTTCGATGTCCTTCTGCCTCGGGACTGGCAGATGGCGCCAGGGAGAGGACTCCCCAACCTGCTCA
CCTTCTACAGAAAATCTTCAAGAAAACCCTCCAGTCATCGTAACGCGTGTCCTCCAAGCCCTCGGAACTGTGGCTGTGGCTCTGGGGGCT
CTAGGAGCTGCCTACTACATCACTGAATCCTTGTGAACAAGCCCCTAGGCCCACAGTCTGGCAGGAGGTGCTTTTAATGTGCTGATAAAC
CAACCTCAGGAAGGTATTATGTACAGAAGATTCCCAAGGCTGCTGTTGCTGAAAGAGACTTGGGCTACTGCCAGGGAACTAGAAACGTGC

>22913_22913_4_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000273009_SPATA3_chr2_231865080_ENST00000455816_length(amino acids)=505AA_BP=413
MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK
KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA
QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN
SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS
SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGPLIRAGPHSCSCATCPCSSACWRRLGLCHSRIFDVL

--------------------------------------------------------------
>22913_22913_5_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000325385_SPATA3_chr2_231865080_ENST00000424440_length(transcript)=2077nt_BP=1480nt
TTTCGCCCTTGTCGCAGCTGAACCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCAC
CGTCGCTCTCTAGAACGCCGCGCCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAA
ACGCGAATGACAACAGAGCTGCTCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAG
CCAATAATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATT
GGTGCTTCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGAT
GTTTCAGAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCG
GATGGTGATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAG
GAGCATTGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACAC
CATCTCCCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGA
CATGGCATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCG
GTTACAAAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATC
TTGGAGAAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTT
TCTCCCTCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAAC
ACACTGTTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAA
ATTGAGCCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGC
CTGCCATGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGA
GACCTCGATGATGCCCTCTCCTGCAAGCCACTCGCTGACGGGCCTCTGATTCGCGCCGGCCCGCATTCCTGCTCCTGTGCCACTTGCCCC
TGCAGCTCCGCTTGCTGGCGTCGTCTGGGGCTATGCCATAGCCGCATCTTCGATGTCCTTCTGCCTCGGGACTGGCAGATGGCGCCAGGG
AGAGGACTCCCCAACCTGCTCACCTTCTACAGAAAATCTTCAAGAAAACCCTCCAGTCATCGTAACGCGTGTCCTCCAAGCCCTCGGAAC
TGTGGCTGTGGCTCTGGGGGCTCTAGGAGCTGCCTACTACATCACTGAATCCTTGTGAACAAGCCCCTAGGCCCACAGTCTGGCAGACCT
CCACCAGCCCCAGGAGTTGATAGGTGATGGCGCTGGGAGAAGATGTTCAGAATATCTCAAAAGCCAAGTCCAGAAGTTTGATGTCCTTCC
CTGTCCAGAGAGTGAAGAACCATCTGACGACAGTGACATCTTTCCTTTTTGGGGAAAGATGCTTCTAGAATTTTCTTTCCTAAAGTTTGG
TGAACCTCTCCCTTGGCATCTTCCTCAGCTGAAGATCCAGTTTCCATCAAAGGGACCTCTCTTGTCACCAAAATTTAAAAAAAGAAAAAA

>22913_22913_5_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000325385_SPATA3_chr2_231865080_ENST00000424440_length(amino acids)=505AA_BP=413
MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK
KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA
QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN
SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS
SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGPLIRAGPHSCSCATCPCSSACWRRLGLCHSRIFDVL

--------------------------------------------------------------
>22913_22913_6_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000325385_SPATA3_chr2_231865080_ENST00000433428_length(transcript)=1939nt_BP=1480nt
TTTCGCCCTTGTCGCAGCTGAACCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCAC
CGTCGCTCTCTAGAACGCCGCGCCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAA
ACGCGAATGACAACAGAGCTGCTCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAG
CCAATAATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATT
GGTGCTTCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGAT
GTTTCAGAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCG
GATGGTGATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAG
GAGCATTGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACAC
CATCTCCCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGA
CATGGCATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCG
GTTACAAAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATC
TTGGAGAAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTT
TCTCCCTCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAAC
ACACTGTTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAA
ATTGAGCCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGC
CTGCCATGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGA
GACCTCGATGATGCCCTCTCCTGCAAGCCACTCGCTGACGGGCCTCTGATTCGCGCCGGCCCGCATTCCTGCTCCTGTGCCACTTGCCCC
TGCAGCTCCGCTTGCTGGCGTCGTCTGGGGCTATGCCATAGCCGCATCTTCGATGTCCTTCTGCCTCGGGACTGGCAGATGGCGCCAGGG
AGAGGACTCCCCAACCTGCTCACCTTCTACAGAAAATCTTCAAGAAAACCCTCCAGTCATCGTAACGCGTGTCCTCCAAGCCCTCGGAAC
TGTGGCTGTGGCTCTGGGGGCTCTAGGAGCTGCCTACTACATCACTGAATCCTTGTGAACAAGCCCCTAGGCCCACAGTCTGGCAGACCT
CCACCAGCCCCAGGAGTTGATAGGTGATGGCGCTGGGAGAAGATGTTCAGAATATCTCAAAAGCCAAGTCCAGAAGATCCAGTTTCCATC

>22913_22913_6_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000325385_SPATA3_chr2_231865080_ENST00000433428_length(amino acids)=505AA_BP=413
MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK
KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA
QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN
SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS
SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGPLIRAGPHSCSCATCPCSSACWRRLGLCHSRIFDVL

--------------------------------------------------------------
>22913_22913_7_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000325385_SPATA3_chr2_231865080_ENST00000452881_length(transcript)=2689nt_BP=1480nt
TTTCGCCCTTGTCGCAGCTGAACCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCAC
CGTCGCTCTCTAGAACGCCGCGCCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAA
ACGCGAATGACAACAGAGCTGCTCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAG
CCAATAATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATT
GGTGCTTCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGAT
GTTTCAGAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCG
GATGGTGATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAG
GAGCATTGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACAC
CATCTCCCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGA
CATGGCATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCG
GTTACAAAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATC
TTGGAGAAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTT
TCTCCCTCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAAC
ACACTGTTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAA
ATTGAGCCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGC
CTGCCATGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGA
GACCTCGATGATGCCCTCTCCTGCAAGCCACTCGCTGACGGGCCTCTGATTCGCGCCGGCCCGCATTCCTGCTCCTGTGCCACTTGCCCC
TGCAGCTCCGCTTGCTGGCGTCGTCTGGGGCTATGCCATAGCCGCATCTTCGATGTCCTTCTGCCTCGGGACTGGCAGATGGCGCCAGGG
AGAGGACTCCCCAACCTGCTCACCTTCTACAGAAAATCTTCAAGAAAACCCTCCAGTCATCGTAACGCGTGTCCTCCAAGCCCTCGGAAC
TGTGGCTGTGGCTCTGGGGGCTCTAGGAGCTGCCTACTACATCACTGAATCCTTGTGAACAAGCCCCTAGGCCCACAGTCTGGCAGACCT
CCACCAGCCCCAGGAGTTGATAGGTGATGGCGCTGGGAGAAGATGTTCAGAATATCTCAAAAGCCAAGTCCAGAAGGAGGTGCTTTTAAT
GTGCTGATAAACCAACCTCAGGAAGGTATTATGTACAGAAGATTCCCAAGGCTGCTGTTGCTGAAAGAGACTTGGGCTACTGCCAGGGAA
CTAGGGTCTCACTCTGTCACCCAGGTTGGAGTGCAGCAGGGGCATGATCAGCTCACTGAAGGATCATTTCTTGGTCTAGGCTATAGGCTG
GCCTTAGAATCAACTCACCTGGTGTCCTATTGTCAGGGACATCTTAACCAGGGTGACTGCACCTCGAATAAAGGCCAGATAAAGCCAAAC
TTGCTGGGTTACATTCCTTGGGGGTTAGACACCCTTCATCACAAGATGTTTGTAGCTCAAAGAAGGGGTTAATGATGCTAACTAGAGACC
CAGAACGTCTGAAAACGTCCTGATATTTAAAGAACAAAGCATCCTTCATTTGAGAATAAGTTTCACTTTAAAGACCCCCTCAATATCCTC
CTCAGATTTGCCCTGCACTTCTTGTTCCATGCTTGGGGTCCTAAGAACAAGCCATCTGATGCCTCTACTATCATTACCTCTATTGGGACC
CAGAAACCAATACCCCAAAATATGGTGCATGGACATGCTGAACTGAAGAAGATGCCTCAAGGGTCATCCCTAAAGGCAAAAACAGAACTT
CCAAAGTATCTTTCTGTGACAACATTAGGTTCAGGCTTGAAGTCCCTGATTTCGCCATCAAAGTCAGATCCAGGGGGGACGATGCTATTC

>22913_22913_7_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000325385_SPATA3_chr2_231865080_ENST00000452881_length(amino acids)=505AA_BP=413
MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK
KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA
QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN
SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS
SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGPLIRAGPHSCSCATCPCSSACWRRLGLCHSRIFDVL

--------------------------------------------------------------
>22913_22913_8_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000325385_SPATA3_chr2_231865080_ENST00000455816_length(transcript)=1945nt_BP=1480nt
TTTCGCCCTTGTCGCAGCTGAACCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCAC
CGTCGCTCTCTAGAACGCCGCGCCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAA
ACGCGAATGACAACAGAGCTGCTCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAG
CCAATAATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATT
GGTGCTTCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGAT
GTTTCAGAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCG
GATGGTGATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAG
GAGCATTGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACAC
CATCTCCCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGA
CATGGCATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCG
GTTACAAAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATC
TTGGAGAAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTT
TCTCCCTCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAAC
ACACTGTTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAA
ATTGAGCCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGC
CTGCCATGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGA
GACCTCGATGATGCCCTCTCCTGCAAGCCACTCGCTGACGGGCCTCTGATTCGCGCCGGCCCGCATTCCTGCTCCTGTGCCACTTGCCCC
TGCAGCTCCGCTTGCTGGCGTCGTCTGGGGCTATGCCATAGCCGCATCTTCGATGTCCTTCTGCCTCGGGACTGGCAGATGGCGCCAGGG
AGAGGACTCCCCAACCTGCTCACCTTCTACAGAAAATCTTCAAGAAAACCCTCCAGTCATCGTAACGCGTGTCCTCCAAGCCCTCGGAAC
TGTGGCTGTGGCTCTGGGGGCTCTAGGAGCTGCCTACTACATCACTGAATCCTTGTGAACAAGCCCCTAGGCCCACAGTCTGGCAGGAGG
TGCTTTTAATGTGCTGATAAACCAACCTCAGGAAGGTATTATGTACAGAAGATTCCCAAGGCTGCTGTTGCTGAAAGAGACTTGGGCTAC

>22913_22913_8_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000325385_SPATA3_chr2_231865080_ENST00000455816_length(amino acids)=505AA_BP=413
MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK
KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA
QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN
SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS
SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGPLIRAGPHSCSCATCPCSSACWRRLGLCHSRIFDVL

--------------------------------------------------------------
>22913_22913_9_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000409307_SPATA3_chr2_231865080_ENST00000424440_length(transcript)=1801nt_BP=1204nt
ATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCT
TCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCA
GAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGT
GATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCAT
TGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTC
CCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGC
ATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACA
AAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAG
AAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCC
TCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTG
TTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAG
CCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCA
TGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGAGACCTC
GATGATGCCCTCTCCTGCAAGCCACTCGCTGACGGGCCTCTGATTCGCGCCGGCCCGCATTCCTGCTCCTGTGCCACTTGCCCCTGCAGC
TCCGCTTGCTGGCGTCGTCTGGGGCTATGCCATAGCCGCATCTTCGATGTCCTTCTGCCTCGGGACTGGCAGATGGCGCCAGGGAGAGGA
CTCCCCAACCTGCTCACCTTCTACAGAAAATCTTCAAGAAAACCCTCCAGTCATCGTAACGCGTGTCCTCCAAGCCCTCGGAACTGTGGC
TGTGGCTCTGGGGGCTCTAGGAGCTGCCTACTACATCACTGAATCCTTGTGAACAAGCCCCTAGGCCCACAGTCTGGCAGACCTCCACCA
GCCCCAGGAGTTGATAGGTGATGGCGCTGGGAGAAGATGTTCAGAATATCTCAAAAGCCAAGTCCAGAAGTTTGATGTCCTTCCCTGTCC
AGAGAGTGAAGAACCATCTGACGACAGTGACATCTTTCCTTTTTGGGGAAAGATGCTTCTAGAATTTTCTTTCCTAAAGTTTGGTGAACC
TCTCCCTTGGCATCTTCCTCAGCTGAAGATCCAGTTTCCATCAAAGGGACCTCTCTTGTCACCAAAATTTAAAAAAAGAAAAAAAAAACG

>22913_22913_9_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000409307_SPATA3_chr2_231865080_ENST00000424440_length(amino acids)=493AA_BP=401
MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG
DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG
ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP
SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP
WTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGPLIRAGPHSCSCATCPCSSACWRRLGLCHSRIFDVLLPRDWQMAPGRG

--------------------------------------------------------------
>22913_22913_10_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000409307_SPATA3_chr2_231865080_ENST00000433428_length(transcript)=1663nt_BP=1204nt
ATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCT
TCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCA
GAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGT
GATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCAT
TGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTC
CCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGC
ATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACA
AAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAG
AAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCC
TCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTG
TTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAG
CCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCA
TGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGAGACCTC
GATGATGCCCTCTCCTGCAAGCCACTCGCTGACGGGCCTCTGATTCGCGCCGGCCCGCATTCCTGCTCCTGTGCCACTTGCCCCTGCAGC
TCCGCTTGCTGGCGTCGTCTGGGGCTATGCCATAGCCGCATCTTCGATGTCCTTCTGCCTCGGGACTGGCAGATGGCGCCAGGGAGAGGA
CTCCCCAACCTGCTCACCTTCTACAGAAAATCTTCAAGAAAACCCTCCAGTCATCGTAACGCGTGTCCTCCAAGCCCTCGGAACTGTGGC
TGTGGCTCTGGGGGCTCTAGGAGCTGCCTACTACATCACTGAATCCTTGTGAACAAGCCCCTAGGCCCACAGTCTGGCAGACCTCCACCA
GCCCCAGGAGTTGATAGGTGATGGCGCTGGGAGAAGATGTTCAGAATATCTCAAAAGCCAAGTCCAGAAGATCCAGTTTCCATCAAAGGG

>22913_22913_10_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000409307_SPATA3_chr2_231865080_ENST00000433428_length(amino acids)=493AA_BP=401
MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG
DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG
ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP
SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP
WTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGPLIRAGPHSCSCATCPCSSACWRRLGLCHSRIFDVLLPRDWQMAPGRG

--------------------------------------------------------------
>22913_22913_11_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000409307_SPATA3_chr2_231865080_ENST00000452881_length(transcript)=2413nt_BP=1204nt
ATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCT
TCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCA
GAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGT
GATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCAT
TGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTC
CCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGC
ATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACA
AAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAG
AAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCC
TCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTG
TTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAG
CCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCA
TGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGAGACCTC
GATGATGCCCTCTCCTGCAAGCCACTCGCTGACGGGCCTCTGATTCGCGCCGGCCCGCATTCCTGCTCCTGTGCCACTTGCCCCTGCAGC
TCCGCTTGCTGGCGTCGTCTGGGGCTATGCCATAGCCGCATCTTCGATGTCCTTCTGCCTCGGGACTGGCAGATGGCGCCAGGGAGAGGA
CTCCCCAACCTGCTCACCTTCTACAGAAAATCTTCAAGAAAACCCTCCAGTCATCGTAACGCGTGTCCTCCAAGCCCTCGGAACTGTGGC
TGTGGCTCTGGGGGCTCTAGGAGCTGCCTACTACATCACTGAATCCTTGTGAACAAGCCCCTAGGCCCACAGTCTGGCAGACCTCCACCA
GCCCCAGGAGTTGATAGGTGATGGCGCTGGGAGAAGATGTTCAGAATATCTCAAAAGCCAAGTCCAGAAGGAGGTGCTTTTAATGTGCTG
ATAAACCAACCTCAGGAAGGTATTATGTACAGAAGATTCCCAAGGCTGCTGTTGCTGAAAGAGACTTGGGCTACTGCCAGGGAACTAGGG
TCTCACTCTGTCACCCAGGTTGGAGTGCAGCAGGGGCATGATCAGCTCACTGAAGGATCATTTCTTGGTCTAGGCTATAGGCTGGCCTTA
GAATCAACTCACCTGGTGTCCTATTGTCAGGGACATCTTAACCAGGGTGACTGCACCTCGAATAAAGGCCAGATAAAGCCAAACTTGCTG
GGTTACATTCCTTGGGGGTTAGACACCCTTCATCACAAGATGTTTGTAGCTCAAAGAAGGGGTTAATGATGCTAACTAGAGACCCAGAAC
GTCTGAAAACGTCCTGATATTTAAAGAACAAAGCATCCTTCATTTGAGAATAAGTTTCACTTTAAAGACCCCCTCAATATCCTCCTCAGA
TTTGCCCTGCACTTCTTGTTCCATGCTTGGGGTCCTAAGAACAAGCCATCTGATGCCTCTACTATCATTACCTCTATTGGGACCCAGAAA
CCAATACCCCAAAATATGGTGCATGGACATGCTGAACTGAAGAAGATGCCTCAAGGGTCATCCCTAAAGGCAAAAACAGAACTTCCAAAG
TATCTTTCTGTGACAACATTAGGTTCAGGCTTGAAGTCCCTGATTTCGCCATCAAAGTCAGATCCAGGGGGGACGATGCTATTCAGAAAC

>22913_22913_11_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000409307_SPATA3_chr2_231865080_ENST00000452881_length(amino acids)=493AA_BP=401
MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG
DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG
ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP
SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP
WTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGPLIRAGPHSCSCATCPCSSACWRRLGLCHSRIFDVLLPRDWQMAPGRG

--------------------------------------------------------------
>22913_22913_12_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000409307_SPATA3_chr2_231865080_ENST00000455816_length(transcript)=1669nt_BP=1204nt
ATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCT
TCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCA
GAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGT
GATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCAT
TGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTC
CCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGC
ATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACA
AAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAG
AAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCC
TCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTG
TTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAG
CCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCA
TGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGAGACCTC
GATGATGCCCTCTCCTGCAAGCCACTCGCTGACGGGCCTCTGATTCGCGCCGGCCCGCATTCCTGCTCCTGTGCCACTTGCCCCTGCAGC
TCCGCTTGCTGGCGTCGTCTGGGGCTATGCCATAGCCGCATCTTCGATGTCCTTCTGCCTCGGGACTGGCAGATGGCGCCAGGGAGAGGA
CTCCCCAACCTGCTCACCTTCTACAGAAAATCTTCAAGAAAACCCTCCAGTCATCGTAACGCGTGTCCTCCAAGCCCTCGGAACTGTGGC
TGTGGCTCTGGGGGCTCTAGGAGCTGCCTACTACATCACTGAATCCTTGTGAACAAGCCCCTAGGCCCACAGTCTGGCAGGAGGTGCTTT
TAATGTGCTGATAAACCAACCTCAGGAAGGTATTATGTACAGAAGATTCCCAAGGCTGCTGTTGCTGAAAGAGACTTGGGCTACTGCCAG

>22913_22913_12_DIS3L2-SPATA3_DIS3L2_chr2_233075115_ENST00000409307_SPATA3_chr2_231865080_ENST00000455816_length(amino acids)=493AA_BP=401
MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG
DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG
ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP
SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP
WTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGPLIRAGPHSCSCATCPCSSACWRRLGLCHSRIFDVLLPRDWQMAPGRG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DIS3L2-SPATA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DIS3L2-SPATA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DIS3L2-SPATA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource