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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:DIS3L2-SPHKAP (FusionGDB2 ID:22914) |
Fusion Gene Summary for DIS3L2-SPHKAP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DIS3L2-SPHKAP | Fusion gene ID: 22914 | Hgene | Tgene | Gene symbol | DIS3L2 | SPHKAP | Gene ID | 129563 | 80309 |
| Gene name | DIS3 like 3'-5' exoribonuclease 2 | SPHK1 interactor, AKAP domain containing | |
| Synonyms | FAM6A|PRLMNS|hDIS3L2 | SKIP | |
| Cytomap | 2q37.1 | 2q36.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DIS3-like exonuclease 2DIS3 mitotic control homolog-like 2family with sequence similarity 6, member A | A-kinase anchor protein SPHKAPSPHK1 (sphingosine kinase type 1) interacting proteinSPHK1-interactor and AKAP domain-containing proteinsphingosine kinase type 1-interacting protein | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q8IYB7 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000325385, ENST00000409307, ENST00000273009, ENST00000360410, ENST00000409401, ENST00000470087, | ENST00000344657, ENST00000392056, | |
| Fusion gene scores | * DoF score | 27 X 9 X 12=2916 | 2 X 2 X 2=8 |
| # samples | 25 | 2 | |
| ** MAII score | log2(25/2916*10)=-3.54399071966485 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: DIS3L2 [Title/Abstract] AND SPHKAP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DIS3L2(233164829)-SPHKAP(228996801), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DIS3L2 | GO:0010587 | miRNA catabolic process | 24141620 |
| Fusion gene breakpoints across DIS3L2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across SPHKAP (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-A1-A0SK-01A | DIS3L2 | chr2 | 233164829 | - | SPHKAP | chr2 | 228996801 | - |
| ChimerDB4 | BRCA | TCGA-A1-A0SK-01A | DIS3L2 | chr2 | 233164829 | + | SPHKAP | chr2 | 228996801 | - |
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Fusion Gene ORF analysis for DIS3L2-SPHKAP |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000325385 | ENST00000344657 | DIS3L2 | chr2 | 233164829 | + | SPHKAP | chr2 | 228996801 | - |
| In-frame | ENST00000325385 | ENST00000392056 | DIS3L2 | chr2 | 233164829 | + | SPHKAP | chr2 | 228996801 | - |
| In-frame | ENST00000409307 | ENST00000344657 | DIS3L2 | chr2 | 233164829 | + | SPHKAP | chr2 | 228996801 | - |
| In-frame | ENST00000409307 | ENST00000392056 | DIS3L2 | chr2 | 233164829 | + | SPHKAP | chr2 | 228996801 | - |
| intron-3CDS | ENST00000273009 | ENST00000344657 | DIS3L2 | chr2 | 233164829 | + | SPHKAP | chr2 | 228996801 | - |
| intron-3CDS | ENST00000273009 | ENST00000392056 | DIS3L2 | chr2 | 233164829 | + | SPHKAP | chr2 | 228996801 | - |
| intron-3CDS | ENST00000360410 | ENST00000344657 | DIS3L2 | chr2 | 233164829 | + | SPHKAP | chr2 | 228996801 | - |
| intron-3CDS | ENST00000360410 | ENST00000392056 | DIS3L2 | chr2 | 233164829 | + | SPHKAP | chr2 | 228996801 | - |
| intron-3CDS | ENST00000409401 | ENST00000344657 | DIS3L2 | chr2 | 233164829 | + | SPHKAP | chr2 | 228996801 | - |
| intron-3CDS | ENST00000409401 | ENST00000392056 | DIS3L2 | chr2 | 233164829 | + | SPHKAP | chr2 | 228996801 | - |
| intron-3CDS | ENST00000470087 | ENST00000344657 | DIS3L2 | chr2 | 233164829 | + | SPHKAP | chr2 | 228996801 | - |
| intron-3CDS | ENST00000470087 | ENST00000392056 | DIS3L2 | chr2 | 233164829 | + | SPHKAP | chr2 | 228996801 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000325385 | DIS3L2 | chr2 | 233164829 | + | ENST00000392056 | SPHKAP | chr2 | 228996801 | - | 8853 | 2015 | 240 | 7085 | 2281 |
| ENST00000325385 | DIS3L2 | chr2 | 233164829 | + | ENST00000344657 | SPHKAP | chr2 | 228996801 | - | 8759 | 2015 | 240 | 6998 | 2252 |
| ENST00000409307 | DIS3L2 | chr2 | 233164829 | + | ENST00000392056 | SPHKAP | chr2 | 228996801 | - | 8577 | 1739 | 0 | 6809 | 2269 |
| ENST00000409307 | DIS3L2 | chr2 | 233164829 | + | ENST00000344657 | SPHKAP | chr2 | 228996801 | - | 8483 | 1739 | 0 | 6722 | 2240 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000325385 | ENST00000392056 | DIS3L2 | chr2 | 233164829 | + | SPHKAP | chr2 | 228996801 | - | 0.000572441 | 0.99942756 |
| ENST00000325385 | ENST00000344657 | DIS3L2 | chr2 | 233164829 | + | SPHKAP | chr2 | 228996801 | - | 0.000631399 | 0.9993686 |
| ENST00000409307 | ENST00000392056 | DIS3L2 | chr2 | 233164829 | + | SPHKAP | chr2 | 228996801 | - | 0.000393396 | 0.99960667 |
| ENST00000409307 | ENST00000344657 | DIS3L2 | chr2 | 233164829 | + | SPHKAP | chr2 | 228996801 | - | 0.000432455 | 0.99956757 |
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Fusion Genomic Features for DIS3L2-SPHKAP |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for DIS3L2-SPHKAP |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:233164829/chr2:228996801) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DIS3L2 | . |
| FUNCTION: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. {ECO:0000255|HAMAP-Rule:MF_03045, ECO:0000269|PubMed:23756462, ECO:0000269|PubMed:24141620}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | SPHKAP | chr2:233164829 | chr2:228996801 | ENST00000344657 | 0 | 11 | 929_946 | 10 | 1672.0 | Region | PKA-RII subunit binding domain | |
| Tgene | SPHKAP | chr2:233164829 | chr2:228996801 | ENST00000392056 | 0 | 12 | 929_946 | 10 | 1701.0 | Region | PKA-RII subunit binding domain |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for DIS3L2-SPHKAP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >22914_22914_1_DIS3L2-SPHKAP_DIS3L2_chr2_233164829_ENST00000325385_SPHKAP_chr2_228996801_ENST00000344657_length(transcript)=8759nt_BP=2015nt TTTCGCCCTTGTCGCAGCTGAACCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCAC CGTCGCTCTCTAGAACGCCGCGCCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAA ACGCGAATGACAACAGAGCTGCTCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAG CCAATAATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATT GGTGCTTCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGAT GTTTCAGAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCG GATGGTGATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAG GAGCATTGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACAC CATCTCCCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGA CATGGCATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCG GTTACAAAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATC TTGGAGAAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTT TCTCCCTCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAAC ACACTGTTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAA ATTGAGCCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGC CTGCCATGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGA GACCTCGATGATGCCCTCTCCTGCAAGCCACTCGCTGACGGCAACTTCAAAGTGGGAGTTCACATTGCTGACGTGAGTTACTTTGTTCCG GAGGGATCTGATCTGGATAAAGTGGCTGCCGAGAGGGCTACAAGCGTCTACTTGGTTCAAAAGGTGGTCCCCATGCTTCCCAGGCTGCTG TGTGAGGAGCTGTGCAGCCTCAACCCCATGTCCGACAAGCTGACCTTCTCTGTGATCTGGACACTGACTCCAGAGGGCAAGATCCTTGAT GAATGGTTTGGCCGGACCATCATCCGCTCCTGCACCAAACTTAGCTACGAGCATGCACAGAGCATGATTGAAAGCCCAACTGAGAAAATC CCTGCGAAAGAGCTGCCCCCCATTTCCCCAGAGCATAGCAGCGAGGAGGTACACCAGGCCGTCTTGAATCTCCACGGAATTGCCAAGCAG TTACGCCAGCAGCGCTTTGTGGACGGCGCACTTCGTTTGGATCAGCTAAAGCTTGCTTTCACTCTGGACCACGAGACCGGATTGCCTCAA GGATGTCATATCTATGAGTACCGCGAGAGCAACAACAACTTGGAGTCATCACGGATGTATGACGTTTTGGAACCGCAGCAGGGCAGAGGC TGTGGCAGCTCAGGAAGCGGCCCGGGGAACTCCATCACAGCCTGTAAGAAGGTTCTTCGCAGCAATAGCCTGCTGGAGTCAACAGACTAC TGGTTGCAGAATCAGAGGATGCCCTGCCAAATTGGTTTTGTAGAAGACAAGTCTGAAAACTGTGCTTCTGTCTGCTTTGTGAATCTTGAT GTGAACAAGGATGAATGCAGCACAGAGCACCTGCAACAGAAACTGGTCAACGTTTCACCAGATCTTCCAAAACTTATCAGTTCCATGAAT GTCCAACAACCAAAAGAAAATGAAATTGTTGTCCTAAGTGGGTTAGCCTCTGGAAATCTCCAGGCAGATTTTGAAGTTTCACAGTGCCCT TGGCTGCCAGATATCTGCTTGGTCCAATGTGCAAGAGGGAACAGACCAAACAGTACCAACTGCATCATCTTTGAAATCAACAAATTTCTG ATTGGTCTGGAACTGGTGCAGGAGCGACAGCTCCACCTGGAAACAAACATCTTGAAACTGGAGGATGACACGAACTGTTCCTTATCTTCA ATCGAGGAAGACTTTCTCACCGCTTCTGAGCACTTGGAGGAGGAAAGCGAGGTGGATGAATCTAGGAACGATTATGAAAATATAAATGTC TCAGCCAATGTTTTGGAAAGTAAACAGCTAAAGGGAGCCACCCAGGTGGAATGGAATTGCAACAAGGAAAAGTGGCTTTATGCTTTGGAA GACAAATACATCAACAAATATCCCACACCATTGATTAAAACAGAACGATCTCCAGAAAACCTAACAAAGAACACAGCCTTGCAGAGTCTA GATCCCTCAGCCAAGCCATCACAGTGGAAAAGAGAAGCTGTGGGGAATGGGAGACAAGCCACACATTATTATCATTCAGAAGCTTTTAAA GGTCAAATGGAAAAATCACAGGCACTGTATATTCCAAAAGATGCTTATTTCTCCATGATGGATAAAGATGTACCTTCTGCATGTGCTGTG GCAGAGCAGAGAAGCAACCTAAACCCAGGAGACCATGAAGACACAAGAAACGCTCTCCCTCCTAGACAAGATGGAGAAGTCACCACTGGC AAGTATGCTACAAATTTAGCAGAATCCGTGCTGCAGGATGCATTTATTAGATTATCTCAATCTCAGTCCACATTACCCCAGGAATCTGCA GTCAGTGTTTCTGTAGGAAGTTCTCTGCTTCCCAGTTGCTATTCCACAAAAGATACAGTGGTTTCTCGGTCATGGAATGAGCTCCCCAAA ATCGTCGTTGTTCAGAGTCCAGATGGCAGTGATGCTGCCCCACAGCCAGGCATCTCCTCCTGGCCTGAGATGGAAGTCTCTGTTGAAACC TCAAGCATCCTCTCTGGAGAGAACTCCAGCAGACAACCCCAGAGTGCTCTAGAAGTGGCGTTAGCTTGTGCAGCCACTGTGATTGGAACT ATTTCCAGTCCACAGGCCACAGAAAGACTCAAAATGGAGCAAGTGGTCTCGAACTTTCCCCCAGGGAGCAGTGGTGCACTGCAAACTCAA GCACCCCAAGGACTCAAGGAACCTTCCATCAATGAGTACTCCTTTCCATCTGCTTTGTGTGGCATGACTCAGGTGGCCAGTGCCGTGGCT GTCTGTGGTCTGGGTGAAAGAGAAGAGGTGACATGCTCAGTGGCTCCAAGTGGTAGCCTCCCGCCTGCAGCTGAGGCTTCTGAAGCCATG CCCCCACTTTGTGGTTTAGCAAGCATGGAGCTTGGCAAGGAAGCCATTGCCAAGGGATTGCTCAAGGAGGCTGCTCTGGTTTTAACAAGG CCTAATACCTACAGCAGCATTGGAGACTTTCTGGACTCCATGAACAGGAGAATCATGGAAACTGCTTCAAAGTCTCAGACCCTGTGCTCA GAAAATGTCGTCAGGAATGAACTGGCACATACCCTGTCCAATGTTATCCTGAGGCATTCCATTGATGAAGTTCACCACAAAAATATGATA ATCGACCCCAATGACAACAGGCATTCATCTGAAATTCTGGACACCTTAATGGAAAGTACAAATCAACTGCTTTTAGATGTGATATGCTTC ACGTTCAAGAAGATGAGTCATATTGTACGGCTTGGTGAATGTCCTGCTGTCCTTTCTAAGGAGACCATCAGAAGGAGGGAGACAGAACCA AGCTGCCAGCCATCTGATCCGGGTGCTAGTCAAGCTTGGACAAAAGCCACTGAATCCTCCAGCAGCTCTCCACTTAGCAATTCACACAAC ACGAGTCTTGTCATCAACAATCTTGTGGATGGCATGTATTCAAAACAAGACAAGGGTGGAGTGAGGCCAGGCCTCTTCAAGAACCCCACG CTGCAGTCACAATTATCACGTAGTCACAGAGTGCCCGATTCTTCAACTGCTACAACATCCTCCAAGGAAATATATCTGAAAGGAATAGCA GGAGAGGATACAAAAAGCCCTCATCACAGTGAGAATGAATGCAGAGCCTCTTCCGAAGGACAAAGGTCCCCAACGGTCAGCCAGTCCAGA AGTGGTTCCCAGGAGGCTGAGGAGAGTATCCACCCAAACACCCAAGAAAAGTACAACTGTGCCACATCTCGCATCAACGAAGTTCAAGTC AACCTGTCCTTGTTAGGGGATGACCTGCTGCTTCCTGCTCAATCCACGCTTCAAACAAAGCATCCAGACATCTACTGCATTACAGACTTT GCGGAAGAATTAGCAGACACGGTCGTCTCCATGGCAACTGAAATTGCAGCGATTTGCCTTGACAACTCCAGTGGAAAACAACCCTGGTTT TGTGCATGGAAAAGAGGGAGTGAGTTTCTGATGACACCCAACGTACCCTGCCGATCCTTGAAGAGGAAGAAAGAGAGCCAGGGGAGCGGG ACCGCTGTGAGGAAACACAAGCCTCCCCGGCTCAGTGAGATCAAGAGGAAGACGGACGAGCACCCTGAGCTTAAAGAAAAGCTGATGAAC AGGGTTGTGGATGAGTCCATGAACCTTGAAGATGTCCCAGATTCTGTCAATCTTTTTGCCAATGAAGTGGCAGCCAAGATCATGAACCTA ACGGAGTTCTCTATGGTGGACGGCATGTGGCAGGCGCAGGGCTATCCCCGGAATCGGTTACTGAGTGGCGACAGGTGGAGCCGGCTGAAG GCCTCCAGCTGCGAAAGCATTCCTGAGGAAGACTCCGAGGCCAGGGCCTATGTCAACAGCCTGGGCTTAATGAGCACGCTGAGCCAGCCG GTCAGCAGGGCCAGCTCTGTCTCCAAGCAGTCGAGCTGTGAGAGCATCACCGATGAGTTTTCCAGGTTCATGGTGAACCAGATGGAAAAT GAAGGGAGAGGATTTGAGTTACTGCTGGATTACTATGCTGGCAAGAACGCCAGCAGCATTCTGAACTCAGCCATGCAACAGGCGTGCCGG AAAAGTGACCACCTCAGTGTGAGGCCTAGCTGTCCCTCTAAGCAGTCCAGCACAGAGAGCATCACTGAGGAGTTCTACAGGTACATGCTG AGGGACATCGAAAGAGACAGCAGAGAAAGTGCCTCCTCCAGACGGAGCAGCCAGGATTGGACAGCCGGCCTGCTGTCTCCTTCTCTGCGA TCCCCAGTGTGCCACAGACAGTCGTCCATGCCAGACAGCAGATCCCCATGCTCCAGGCTGACAGTGAATGTGCCCATCAAAGCCAACTCT TTAGATGGCTTTGCTCAGAACTGCCCACAAGATTTCCTAAGCGTGCAGCCGGTCAGTAGCGCGTCCTCATCCGGTCTCTGCAAATCTGAC TCTTGCTTGTATCGGAGAGGTGGGACTGACCACATCACCAACATGTTAATTCATGAAACGTGGGCTAGCTCCATTGAGGCTCTCATGCGC AAGAACAAAATCATTGTGGATGATGCAGAGGAAGCTGACACTGAGCCTGTTTCTGGTGGCTCTCCCTCGCAAGCAGAGAAGTGTGCAAAT AGATTAGCTGCGAGCAGGATGTGCAGTGGGCCAACTCTGCTTGTTCAGGAGTCTCTCGATTGCCCGAGGAAAGACTCTGTTACCGAATGT AAACAGCCCCCAGTGTCATCTTTGAGCAAAACTGCTTCTCTTACAAACCACAGCCCTTTAGATTCTAAAAAAGAAACTTCCTCGTGCCAG GACCCTGTACCAATAAACCACAAAAGGCGATCACTTTGCTCGAGGGAAGTGCCTTTGATTCAGATTGAAACAGATCAGAGAGAAGCCTGT GCTGGGGAACCTGAACCCTTCCTTTCCAAAAGCAGCCTCCTAGAGGAAGCAGAAGGGCATTCGAATGACAAAAACATCCCAGATGTGGTG AGAGGTGGAGACACAGCCGTGAGCGCTTGTCAAATCCATAGTGACAGCCTTGATACCAGAGATGTACCAGAGGCTGAAGCCTCCACAGAA GCCAGAGCCCCCGATGAGGCCCCCAACCCTCCAAGCAGCAGCGAGGAGAGCACAGGCAGCTGGACCCAGCTTGCCAATGAGGAAGACAAC CCAGATGACACAAGTAGCTTTCTCCAGCTCAGTGAGCGATCCATGAGTGAATTAGTAGAAGAAAAGAAGATTCTTAAAGGACAGTCAGAA AGCACAGAGGCACCTGCATCTGGACCGCCTACGGGAACAGCCAGCCCCCAGAGGAGCCTGCTGGTGATCAACTTTGACCTGGAGCCAGAG TGTCCAGATGCCGAGCTCCGAGCCACTCTGCAGTGGATAGCTGCCTCTGAACTGGGGATTCCCACCATCTACTTTAAGAAATCTCAGGAA AACAGAATTGAAAAGTTTCTAGATGTCGTGCAGCTGGTTCATCGGAAGTCCTGGAAAGTGGGTGATATCTTCCATGCAGTTGTCCAGTAC TGCAAAATGCATGAGGAGCAGAAGGATGGGAGACTGAGTCTCTTTGACTGGCTCTTGGAACTGGGATAATAAGGCAGTCTGCCGTATAGA TCATTCCTTCCCTTTATTCCAACTTAGATTACAGTGGTTTGTTCTAAATGCTCTAAACATTCTCAAAACATCACATCACATTAGCAGAAC TATAAAAAAAAATCTGCTACTCAGATCCACTGCATACAGAATAAGTCAGAGGAAAAGCAAAATATAGGTCTGTCCAAATTCATACAACTT GTGGGTGAGTTCCAAAGAGCTTGGATTAGAAGGGCTGGACAAAGAGAGAATTCAATGGGGCCCAAATTAGAATGCTTATAATGAGACCCA ATCTCCAGGAAAACAACACTCACATAAGTTTAATCATATAAAATGATTTGTAATGTCTCTAATTAGATGAATCAACTAGAAACAAACTCA GTGGTCAAAATAATTTTTAAGAGTATTCCGTAACCTATATTTTACTTTTCTGATTATATTAAGGGGCTGCCAGCCCGGAGAAATACTTAA GATATGGGTGAGAAATCCCCAGACTTTTATACAAAAGATTTCCACTTTCAAATCAATGTCAGTAGACATTGATAAAAGTATAGCAGCATC CTCTACTGAGGTGATTTCATTTATTCCCTGCAGCCCACTGATAAATATCTCACTTCTCCCAAATAGTATGTGGACTCCCAGCTAAGCAGA AAACTATTGTCATTCAACTGAAGAAGAGGAAGATAAAAGATTGTCTTGTTTCCATCACTGTATTACTTGTGTAACATGATTACATAATTC TTATCCTAAGAGAAAGCTTTCATATTTAAAAAAAAGTCTTTTCAGATAAAATCTGCTTGTGTCTTGAATAATATGAAATACAAACTTTCA CTTTATTTTATTGTAAATTATAAAGAGATTATTGTCTTAAATAATATATTGAGTTAGCTTCAAGCTTCCTAAAATATGAAGAGATTGTTG TCTAAAGTCACATATTGACATTGAGCTCAGTGGCCTGTTTCATCACGTATGTGCTGCTACCTGTACAGCAGACATGCCGCTCCAGTGACA TTTATAATGACAGAAGCAGGGTAATGGTCTTGTGTTTGACATGATCAGTTAGGATCATAGACTTTCCCTGACTCGTAGATATTAGCCTTG AATTGGGGGAAAAGAAGACTTTGACACATTTTAGTTATTTTAATAACAGAGATTTACTCTTTTGAAAAATAAAGGTATCTAATGTCTCCC TAATAAGTCTTCTTTCCTTCCAACTAAATGACCTACACGGACTTTTATTTTCTTGATCAAAGAGGTGTTTATTAAGGACTTCTGGATAAC TATACTTTTACTCTATTTTTAAAGATCACAAAGTAATTTTAAATGTGAACAGGTTCCCATACCATGAATGCTGGCCTCACCTTCTCTATC ATCCACATTTTGAAATGCAAAGAAAGCTCCCTTGTAAGCCATACTTCCTTCCCCACTCCCATCCTAGGATACTTGCCCAGTGCTCATTAG GCATTTCTTATTCAGATAGTCCAAATTTAGGTTATTATGCTTAATTTGACACATTAACTAAATGCCCAGTTTTAAAATATATCCATCAAT TCACGCTGAAATGTGCTTCTTTGTGCTATCAAATGGAATAGAATACACTTATTTTTTAAACAATCCCAGAATACTGTGTGTAGACTTTTG TTGTGCTCAAATAAATGTTTACTTATCTTACAAAGCTCAAATACTGGATTGTAACCATGTGATGAAGTTATCTATGTTGTACCTAACATT >22914_22914_1_DIS3L2-SPHKAP_DIS3L2_chr2_233164829_ENST00000325385_SPHKAP_chr2_228996801_ENST00000344657_length(amino acids)=2252AA_BP=590 MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQ KVVPMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQA VLNLHGIAKQLRQQRFVDGALRLDQLKLAFTLDHETGLPQGCHIYEYRESNNNLESSRMYDVLEPQQGRGCGSSGSGPGNSITACKKVLR SNSLLESTDYWLQNQRMPCQIGFVEDKSENCASVCFVNLDVNKDECSTEHLQQKLVNVSPDLPKLISSMNVQQPKENEIVVLSGLASGNL QADFEVSQCPWLPDICLVQCARGNRPNSTNCIIFEINKFLIGLELVQERQLHLETNILKLEDDTNCSLSSIEEDFLTASEHLEEESEVDE SRNDYENINVSANVLESKQLKGATQVEWNCNKEKWLYALEDKYINKYPTPLIKTERSPENLTKNTALQSLDPSAKPSQWKREAVGNGRQA THYYHSEAFKGQMEKSQALYIPKDAYFSMMDKDVPSACAVAEQRSNLNPGDHEDTRNALPPRQDGEVTTGKYATNLAESVLQDAFIRLSQ SQSTLPQESAVSVSVGSSLLPSCYSTKDTVVSRSWNELPKIVVVQSPDGSDAAPQPGISSWPEMEVSVETSSILSGENSSRQPQSALEVA LACAATVIGTISSPQATERLKMEQVVSNFPPGSSGALQTQAPQGLKEPSINEYSFPSALCGMTQVASAVAVCGLGEREEVTCSVAPSGSL PPAAEASEAMPPLCGLASMELGKEAIAKGLLKEAALVLTRPNTYSSIGDFLDSMNRRIMETASKSQTLCSENVVRNELAHTLSNVILRHS IDEVHHKNMIIDPNDNRHSSEILDTLMESTNQLLLDVICFTFKKMSHIVRLGECPAVLSKETIRRRETEPSCQPSDPGASQAWTKATESS SSSPLSNSHNTSLVINNLVDGMYSKQDKGGVRPGLFKNPTLQSQLSRSHRVPDSSTATTSSKEIYLKGIAGEDTKSPHHSENECRASSEG QRSPTVSQSRSGSQEAEESIHPNTQEKYNCATSRINEVQVNLSLLGDDLLLPAQSTLQTKHPDIYCITDFAEELADTVVSMATEIAAICL DNSSGKQPWFCAWKRGSEFLMTPNVPCRSLKRKKESQGSGTAVRKHKPPRLSEIKRKTDEHPELKEKLMNRVVDESMNLEDVPDSVNLFA NEVAAKIMNLTEFSMVDGMWQAQGYPRNRLLSGDRWSRLKASSCESIPEEDSEARAYVNSLGLMSTLSQPVSRASSVSKQSSCESITDEF SRFMVNQMENEGRGFELLLDYYAGKNASSILNSAMQQACRKSDHLSVRPSCPSKQSSTESITEEFYRYMLRDIERDSRESASSRRSSQDW TAGLLSPSLRSPVCHRQSSMPDSRSPCSRLTVNVPIKANSLDGFAQNCPQDFLSVQPVSSASSSGLCKSDSCLYRRGGTDHITNMLIHET WASSIEALMRKNKIIVDDAEEADTEPVSGGSPSQAEKCANRLAASRMCSGPTLLVQESLDCPRKDSVTECKQPPVSSLSKTASLTNHSPL DSKKETSSCQDPVPINHKRRSLCSREVPLIQIETDQREACAGEPEPFLSKSSLLEEAEGHSNDKNIPDVVRGGDTAVSACQIHSDSLDTR DVPEAEASTEARAPDEAPNPPSSSEESTGSWTQLANEEDNPDDTSSFLQLSERSMSELVEEKKILKGQSESTEAPASGPPTGTASPQRSL LVINFDLEPECPDAELRATLQWIAASELGIPTIYFKKSQENRIEKFLDVVQLVHRKSWKVGDIFHAVVQYCKMHEEQKDGRLSLFDWLLE -------------------------------------------------------------- >22914_22914_2_DIS3L2-SPHKAP_DIS3L2_chr2_233164829_ENST00000325385_SPHKAP_chr2_228996801_ENST00000392056_length(transcript)=8853nt_BP=2015nt TTTCGCCCTTGTCGCAGCTGAACCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCAC CGTCGCTCTCTAGAACGCCGCGCCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAA ACGCGAATGACAACAGAGCTGCTCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAG CCAATAATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATT GGTGCTTCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGAT GTTTCAGAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCG GATGGTGATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAG GAGCATTGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACAC CATCTCCCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGA CATGGCATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCG GTTACAAAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATC TTGGAGAAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTT TCTCCCTCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAAC ACACTGTTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAA ATTGAGCCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGC CTGCCATGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGA GACCTCGATGATGCCCTCTCCTGCAAGCCACTCGCTGACGGCAACTTCAAAGTGGGAGTTCACATTGCTGACGTGAGTTACTTTGTTCCG GAGGGATCTGATCTGGATAAAGTGGCTGCCGAGAGGGCTACAAGCGTCTACTTGGTTCAAAAGGTGGTCCCCATGCTTCCCAGGCTGCTG TGTGAGGAGCTGTGCAGCCTCAACCCCATGTCCGACAAGCTGACCTTCTCTGTGATCTGGACACTGACTCCAGAGGGCAAGATCCTTGAT GAATGGTTTGGCCGGACCATCATCCGCTCCTGCACCAAACTTAGCTACGAGCATGCACAGAGCATGATTGAAAGCCCAACTGAGAAAATC CCTGCGAAAGAGCTGCCCCCCATTTCCCCAGAGCATAGCAGCGAGGAGGTACACCAGGCCGTCTTGAATCTCCACGGAATTGCCAAGCAG TTACGCCAGCAGCGCTTTGTGGACGGCGCACTTCGTTTGGATCAGCTAAAGCTTGCTTTCACTCTGGACCACGAGACCGGATTGCCTCAA GGATGTCATATCTATGAGTACCGCGAGAGCAACAACAACTTGGAGTCATCACGGATGTATGACGTTTTGGAACCGCAGCAGGGCAGAGGC TGTGGCAGCTCAGGAAGCGGCCCGGGGAACTCCATCACAGCCTGTAAGAAGGTTCTTCGCAGCAATAGCCTGCTGGAGTCAACAGACTAC TGGTTGCAGAATCAGAGGATGCCCTGCCAAATTGGTTTTGTAGAAGACAAGTCTGAAAACTGTGCTTCTGTCTGCTTTGTGAATCTTGAT GTGAACAAGGATGAATGCAGCACAGAGCACCTGCAACAGAAACTGGTCAACGTTTCACCAGATCTTCCAAAACTTATCAGTTCCATGAAT GTCCAACAACCAAAAGAAAATGAAATTGTTGTCCTAAGTGGGTTAGCCTCTGGAAATCTCCAGGCAGATTTTGAAGTTTCACAGTGCCCT TGGCTGCCAGATATCTGCTTGGTCCAATGTGCAAGAGGGAACAGACCAAACAGTACCAACTGCATCATCTTTGAAATCAACAAATTTCTG ATTGGTCTGGAACTGGTGCAGGAGCGACAGCTCCACCTGGAAACAAACATCTTGAAACTGGAGGATGACACGAACTGTTCCTTATCTTCA ATCGAGGAAGACTTTCTCACCGCTTCTGAGCACTTGGAGGAGGAAAGCGAGGTGGATGAATCTAGGAACGATTATGAAAATATAAATGTC TCAGCCAATGTTTTGGAAAGTAAACAGCTAAAGGGAGCCACCCAGGTGGAATGGAATTGCAACAAGGAAAAGTGGCTTTATGCTTTGGAA GACAAATACATCAACAAATATCCCACACCATTGATTAAAACAGAACGATCTCCAGAAAACCTAACAAAGAACACAGCCTTGCAGAGTCTA GATCCCTCAGCCAAGCCATCACAGTGGAAAAGAGAAGCTGTGGGGAATGGGAGACAAGCCACACATTATTATCATTCAGAAGCTTTTAAA GGTCAAATGGAAAAATCACAGGCACTGTATATTCCAAAAGATGCTTATTTCTCCATGATGGATAAAGATGTACCTTCTGCATGTGCTGTG GCAGAGCAGAGAAGCAACCTAAACCCAGGAGACCATGAAGACACAAGAAACGCTCTCCCTCCTAGACAAGATGGAGAAGTCACCACTGGC AAGTATGCTACAAATTTAGCAGAATCCGTGCTGCAGGATGCATTTATTAGATTATCTCAATCTCAGTCCACATTACCCCAGGAATCTGCA GTCAGTGTTTCTGTAGGAAGTTCTCTGCTTCCCAGTTGCTATTCCACAAAAGATACAGTGGTTTCTCGGTCATGGAATGAGCTCCCCAAA ATCGTCGTTGTTCAGAGTCCAGATGGCAGTGATGCTGCCCCACAGCCAGGCATCTCCTCCTGGCCTGAGATGGAAGTCTCTGTTGAAACC TCAAGCATCCTCTCTGGAGAGAACTCCAGCAGACAACCCCAGAGTGCTCTAGAAGTGGCGTTAGCTTGTGCAGCCACTGTGATTGGAACT ATTTCCAGTCCACAGGCCACAGAAAGACTCAAAATGGAGCAAGTGGTCTCGAACTTTCCCCCAGGGAGCAGTGGTGCACTGCAAACTCAA GCACCCCAAGGACTCAAGGAACCTTCCATCAATGAGTACTCCTTTCCATCTGCTTTGTGTGGCATGACTCAGGTGGCCAGTGCCGTGGCT GTCTGTGGTCTGGGTGAAAGAGAAGAGGTGACATGCTCAGTGGCTCCAAGTGGTAGCCTCCCGCCTGCAGCTGAGGCTTCTGAAGCCATG CCCCCACTTTGTGGTTTAGCAAGCATGGAGCTTGGCAAGGAAGCCATTGCCAAGGGATTGCTCAAGGAGGCTGCTCTGGTTTTAACAAGG CCTAATACCTACAGCAGCATTGGAGACTTTCTGGACTCCATGAACAGGAGAATCATGGAAACTGCTTCAAAGTCTCAGACCCTGTGCTCA GAAAATGTCGTCAGGAATGAACTGGCACATACCCTGTCCAATGTTATCCTGAGGCATTCCATTGATGAAGTTCACCACAAAAATATGATA ATCGACCCCAATGACAACAGGCATTCATCTGAAATTCTGGACACCTTAATGGAAAGTACAAATCAACTGCTTTTAGATGTGATATGCTTC ACGTTCAAGAAGATGAGTCATATTGTACGGCTTGGTGAATGTCCTGCTGTCCTTTCTAAGGAGACCATCAGAAGGAGGGAGACAGAACCA AGCTGCCAGCCATCTGATCCGGGTGCTAGTCAAGCTTGGACAAAAGCCACTGAATCCTCCAGCAGCTCTCCACTTAGCAATTCACACAAC ACGAGTCTTGTCATCAACAATCTTGTGGATGGCATGTATTCAAAACAAGACAAGGGTGGAGTGAGGCCAGGCCTCTTCAAGAACCCCACG CTGCAGTCACAATTATCACGTAGTCACAGAGTGCCCGATTCTTCAACTGCTACAACATCCTCCAAGGAAATATATCTGAAAGGAATAGCA GGAGAGGATACAAAAAGCCCTCATCACAGTGAGAATGAATGCAGAGCCTCTTCCGAAGGACAAAGGTCCCCAACGGTCAGCCAGTCCAGA AGTGGTTCCCAGGAGGCTGAGGAGAGTATCCACCCAAACACCCAAGAAAAGTACAACTGTGCCACATCTCGCATCAACGAAGTTCAAGTC AACCTGTCCTTGTTAGGGGATGACCTGCTGCTTCCTGCTCAATCCACGCTTCAAACAAAGCATCCAGACATCTACTGCATTACAGACTTT GCGGAAGAATTAGCAGACACGGTCGTCTCCATGGCAACTGAAATTGCAGCGATTTGCCTTGACAACTCCAGTGGAAAACAACCCTGGTTT TGTGCATGGAAAAGAGGGAGTGAGTTTCTGATGACACCCAACGTACCCTGCCGATCCTTGAAGAGGAAGAAAGAGAGCCAGGGGAGCGGG ACCGCTGTGAGGAAACACAAGCCTCCCCGGCTCAGTGAGATCAAGAGGAAGACGGACGAGCACCCTGAGCTTAAAGAAAAGCTGATGAAC AGGGTTGTGGATGAGTCCATGAACCTTGAAGATGTCCCAGATTCTGTCAATCTTTTTGCCAATGAAGTGGCAGCCAAGATCATGAACCTA ACGGAGTTCTCTATGGTGGACGGCATGTGGCAGGCGCAGGGCTATCCCCGGAATCGGTTACTGAGTGGCGACAGGTGGAGCCGGCTGAAG GCCTCCAGCTGCGAAAGCATTCCTGAGGAAGACTCCGAGGCCAGGGCCTATGTCAACAGCCTGGGCTTAATGAGCACGCTGAGCCAGCCG GTCAGCAGGGCCAGCTCTGTCTCCAAGCAGTCGAGCTGTGAGAGCATCACCGATGAGTTTTCCAGGTTCATGGTGAACCAGATGGAAAAT GAAGGGAGAGGATTTGAGTTACTGCTGGATTACTATGCTGGCAAGAACGCCAGCAGCATTCTGAACTCAGCCATGCAACAGGCGTGCCGG AAAAGTGACCACCTCAGTGTGAGGCCTAGCTGTCCCTCTAAGCAGTCCAGCACAGAGAGCATCACTGAGGAGTTCTACAGGTACATGCTG AGGGACATCGAAAGAGACAGCAGAGAAAGTGCCTCCTCCAGACGGAGCAGCCAGGATTGGACAGCCGGCCTGCTGTCTCCTTCTCTGCGA TCCCCAGTGTGCCACAGACAGTCGTCCATGCCAGACAGCAGATCCCCATGCTCCAGGCTGACAGTGAATGTGCCCATCAAAGCCAACTCT TTAGATGGCTTTGCTCAGAACTGCCCACAAGATTTCCTAAGCGTGCAGCCGGTCAGTAGCGCGTCCTCATCCGGTCTCTGCAAATCTGAC TCTTGCTTGTATCGGAGAGGTGGGACTGACCACATCACCAACATGTTAATTCATGAAACGTGGGCTAGCTCCATTGAGGCTCTCATGCGC AAGAACAAAATCATTGTGGATGATGCAGAGGAAGCTGACACTGAGCCTGTTTCTGGTGGCTCTCCCTCGCAAGCAGAGAAGTGTGCAAAT AGATTAGCTGCGAGCAGGATGTGCAGTGGGCCAACTCTGCTTGTTCAGGAGTCTCTCGATTGCCCGAGGAAAGACTCTGTTACCGAATGT AAACAGCCCCCAGTGTCATCTTTGAGCAAAACTGCTTCTCTTACAAACCACAGCCCTTTAGATTCTAAAAAAGAAACTTCCTCGTGCCAG GACCCTGTACCAATAAACCACAAAAGGCGATCACTTTGCTCGAGGGAAGTGCCTTTGATTCAGATTGAAACAGATCAGAGAGAAGCCTGT GCTGGGGAACCTGAACCCTTCCTTTCCAAAAGCAGCCTCCTAGAGGAAGCAGAAGGGCATTCGAATGACAAAAACATCCCAGATGTGGTG AGAGGTGGAGACACAGCCGTGAGCGCTTGTCAAATCCATAGTGACAGCCTTGATACCAGAGATGTACCAGAGGCTGAAGCCTCCACAGAA GCCAGAGCCCCCGATGAGGCCCCCAACCCTCCAAGCAGCAGCGAGGAGAGCACAGGCAGCTGGACCCAGCTTGCCAATGAGGAAGACAAC CCAGATGACACAAGTAGCTTTCTCCAGCTCAGTGAGCGATCCATGAGCAATGGCAACAGTAGTGCCACTAGCAGTCTTGGCATTATGGAT CTGGACATTTATCAGGAAAGCATGCCATCTTCTCCCATGATTAATGAATTAGTAGAAGAAAAGAAGATTCTTAAAGGACAGTCAGAAAGC ACAGAGGCACCTGCATCTGGACCGCCTACGGGAACAGCCAGCCCCCAGAGGAGCCTGCTGGTGATCAACTTTGACCTGGAGCCAGAGTGT CCAGATGCCGAGCTCCGAGCCACTCTGCAGTGGATAGCTGCCTCTGAACTGGGGATTCCCACCATCTACTTTAAGAAATCTCAGGAAAAC AGAATTGAAAAGTTTCTAGATGTCGTGCAGCTGGTTCATCGGAAGTCCTGGAAAGTGGGTGATATCTTCCATGCAGTTGTCCAGTACTGC AAAATGCATGAGGAGCAGAAGGATGGGAGACTGAGTCTCTTTGACTGGCTCTTGGAACTGGGATAATAAGGCAGTCTGCCGTATAGATCA TTCCTTCCCTTTATTCCAACTTAGATTACAGTGGTTTGTTCTAAATGCTCTAAACATTCTCAAAACATCACATCACATTAGCAGAACTAT AAAAAAAAATCTGCTACTCAGATCCACTGCATACAGAATAAGTCAGAGGAAAAGCAAAATATAGGTCTGTCCAAATTCATACAACTTGTG GGTGAGTTCCAAAGAGCTTGGATTAGAAGGGCTGGACAAAGAGAGAATTCAATGGGGCCCAAATTAGAATGCTTATAATGAGACCCAATC TCCAGGAAAACAACACTCACATAAGTTTAATCATATAAAATGATTTGTAATGTCTCTAATTAGATGAATCAACTAGAAACAAACTCAGTG GTCAAAATAATTTTTAAGAGTATTCCGTAACCTATATTTTACTTTTCTGATTATATTAAGGGGCTGCCAGCCCGGAGAAATACTTAAGAT ATGGGTGAGAAATCCCCAGACTTTTATACAAAAGATTTCCACTTTCAAATCAATGTCAGTAGACATTGATAAAAGTATAGCAGCATCCTC TACTGAGGTGATTTCATTTATTCCCTGCAGCCCACTGATAAATATCTCACTTCTCCCAAATAGTATGTGGACTCCCAGCTAAGCAGAAAA CTATTGTCATTCAACTGAAGAAGAGGAAGATAAAAGATTGTCTTGTTTCCATCACTGTATTACTTGTGTAACATGATTACATAATTCTTA TCCTAAGAGAAAGCTTTCATATTTAAAAAAAAGTCTTTTCAGATAAAATCTGCTTGTGTCTTGAATAATATGAAATACAAACTTTCACTT TATTTTATTGTAAATTATAAAGAGATTATTGTCTTAAATAATATATTGAGTTAGCTTCAAGCTTCCTAAAATATGAAGAGATTGTTGTCT AAAGTCACATATTGACATTGAGCTCAGTGGCCTGTTTCATCACGTATGTGCTGCTACCTGTACAGCAGACATGCCGCTCCAGTGACATTT ATAATGACAGAAGCAGGGTAATGGTCTTGTGTTTGACATGATCAGTTAGGATCATAGACTTTCCCTGACTCGTAGATATTAGCCTTGAAT TGGGGGAAAAGAAGACTTTGACACATTTTAGTTATTTTAATAACAGAGATTTACTCTTTTGAAAAATAAAGGTATCTAATGTCTCCCTAA TAAGTCTTCTTTCCTTCCAACTAAATGACCTACACGGACTTTTATTTTCTTGATCAAAGAGGTGTTTATTAAGGACTTCTGGATAACTAT ACTTTTACTCTATTTTTAAAGATCACAAAGTAATTTTAAATGTGAACAGGTTCCCATACCATGAATGCTGGCCTCACCTTCTCTATCATC CACATTTTGAAATGCAAAGAAAGCTCCCTTGTAAGCCATACTTCCTTCCCCACTCCCATCCTAGGATACTTGCCCAGTGCTCATTAGGCA TTTCTTATTCAGATAGTCCAAATTTAGGTTATTATGCTTAATTTGACACATTAACTAAATGCCCAGTTTTAAAATATATCCATCAATTCA CGCTGAAATGTGCTTCTTTGTGCTATCAAATGGAATAGAATACACTTATTTTTTAAACAATCCCAGAATACTGTGTGTAGACTTTTGTTG TGCTCAAATAAATGTTTACTTATCTTACAAAGCTCAAATACTGGATTGTAACCATGTGATGAAGTTATCTATGTTGTACCTAACATTGCA >22914_22914_2_DIS3L2-SPHKAP_DIS3L2_chr2_233164829_ENST00000325385_SPHKAP_chr2_228996801_ENST00000392056_length(amino acids)=2281AA_BP=590 MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQ KVVPMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQA VLNLHGIAKQLRQQRFVDGALRLDQLKLAFTLDHETGLPQGCHIYEYRESNNNLESSRMYDVLEPQQGRGCGSSGSGPGNSITACKKVLR SNSLLESTDYWLQNQRMPCQIGFVEDKSENCASVCFVNLDVNKDECSTEHLQQKLVNVSPDLPKLISSMNVQQPKENEIVVLSGLASGNL QADFEVSQCPWLPDICLVQCARGNRPNSTNCIIFEINKFLIGLELVQERQLHLETNILKLEDDTNCSLSSIEEDFLTASEHLEEESEVDE SRNDYENINVSANVLESKQLKGATQVEWNCNKEKWLYALEDKYINKYPTPLIKTERSPENLTKNTALQSLDPSAKPSQWKREAVGNGRQA THYYHSEAFKGQMEKSQALYIPKDAYFSMMDKDVPSACAVAEQRSNLNPGDHEDTRNALPPRQDGEVTTGKYATNLAESVLQDAFIRLSQ SQSTLPQESAVSVSVGSSLLPSCYSTKDTVVSRSWNELPKIVVVQSPDGSDAAPQPGISSWPEMEVSVETSSILSGENSSRQPQSALEVA LACAATVIGTISSPQATERLKMEQVVSNFPPGSSGALQTQAPQGLKEPSINEYSFPSALCGMTQVASAVAVCGLGEREEVTCSVAPSGSL PPAAEASEAMPPLCGLASMELGKEAIAKGLLKEAALVLTRPNTYSSIGDFLDSMNRRIMETASKSQTLCSENVVRNELAHTLSNVILRHS IDEVHHKNMIIDPNDNRHSSEILDTLMESTNQLLLDVICFTFKKMSHIVRLGECPAVLSKETIRRRETEPSCQPSDPGASQAWTKATESS SSSPLSNSHNTSLVINNLVDGMYSKQDKGGVRPGLFKNPTLQSQLSRSHRVPDSSTATTSSKEIYLKGIAGEDTKSPHHSENECRASSEG QRSPTVSQSRSGSQEAEESIHPNTQEKYNCATSRINEVQVNLSLLGDDLLLPAQSTLQTKHPDIYCITDFAEELADTVVSMATEIAAICL DNSSGKQPWFCAWKRGSEFLMTPNVPCRSLKRKKESQGSGTAVRKHKPPRLSEIKRKTDEHPELKEKLMNRVVDESMNLEDVPDSVNLFA NEVAAKIMNLTEFSMVDGMWQAQGYPRNRLLSGDRWSRLKASSCESIPEEDSEARAYVNSLGLMSTLSQPVSRASSVSKQSSCESITDEF SRFMVNQMENEGRGFELLLDYYAGKNASSILNSAMQQACRKSDHLSVRPSCPSKQSSTESITEEFYRYMLRDIERDSRESASSRRSSQDW TAGLLSPSLRSPVCHRQSSMPDSRSPCSRLTVNVPIKANSLDGFAQNCPQDFLSVQPVSSASSSGLCKSDSCLYRRGGTDHITNMLIHET WASSIEALMRKNKIIVDDAEEADTEPVSGGSPSQAEKCANRLAASRMCSGPTLLVQESLDCPRKDSVTECKQPPVSSLSKTASLTNHSPL DSKKETSSCQDPVPINHKRRSLCSREVPLIQIETDQREACAGEPEPFLSKSSLLEEAEGHSNDKNIPDVVRGGDTAVSACQIHSDSLDTR DVPEAEASTEARAPDEAPNPPSSSEESTGSWTQLANEEDNPDDTSSFLQLSERSMSNGNSSATSSLGIMDLDIYQESMPSSPMINELVEE KKILKGQSESTEAPASGPPTGTASPQRSLLVINFDLEPECPDAELRATLQWIAASELGIPTIYFKKSQENRIEKFLDVVQLVHRKSWKVG -------------------------------------------------------------- >22914_22914_3_DIS3L2-SPHKAP_DIS3L2_chr2_233164829_ENST00000409307_SPHKAP_chr2_228996801_ENST00000344657_length(transcript)=8483nt_BP=1739nt ATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCT TCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCA GAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGT GATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCAT TGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTC CCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGC ATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACA AAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAG AAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCC TCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTG TTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAG CCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCA TGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGAGACCTC GATGATGCCCTCTCCTGCAAGCCACTCGCTGACGGCAACTTCAAAGTGGGAGTTCACATTGCTGACGTGAGTTACTTTGTTCCGGAGGGA TCTGATCTGGATAAAGTGGCTGCCGAGAGGGCTACAAGCGTCTACTTGGTTCAAAAGGTGGTCCCCATGCTTCCCAGGCTGCTGTGTGAG GAGCTGTGCAGCCTCAACCCCATGTCCGACAAGCTGACCTTCTCTGTGATCTGGACACTGACTCCAGAGGGCAAGATCCTTGATGAATGG TTTGGCCGGACCATCATCCGCTCCTGCACCAAACTTAGCTACGAGCATGCACAGAGCATGATTGAAAGCCCAACTGAGAAAATCCCTGCG AAAGAGCTGCCCCCCATTTCCCCAGAGCATAGCAGCGAGGAGGTACACCAGGCCGTCTTGAATCTCCACGGAATTGCCAAGCAGTTACGC CAGCAGCGCTTTGTGGACGGCGCACTTCGTTTGGATCAGCTAAAGCTTGCTTTCACTCTGGACCACGAGACCGGATTGCCTCAAGGATGT CATATCTATGAGTACCGCGAGAGCAACAACAACTTGGAGTCATCACGGATGTATGACGTTTTGGAACCGCAGCAGGGCAGAGGCTGTGGC AGCTCAGGAAGCGGCCCGGGGAACTCCATCACAGCCTGTAAGAAGGTTCTTCGCAGCAATAGCCTGCTGGAGTCAACAGACTACTGGTTG CAGAATCAGAGGATGCCCTGCCAAATTGGTTTTGTAGAAGACAAGTCTGAAAACTGTGCTTCTGTCTGCTTTGTGAATCTTGATGTGAAC AAGGATGAATGCAGCACAGAGCACCTGCAACAGAAACTGGTCAACGTTTCACCAGATCTTCCAAAACTTATCAGTTCCATGAATGTCCAA CAACCAAAAGAAAATGAAATTGTTGTCCTAAGTGGGTTAGCCTCTGGAAATCTCCAGGCAGATTTTGAAGTTTCACAGTGCCCTTGGCTG CCAGATATCTGCTTGGTCCAATGTGCAAGAGGGAACAGACCAAACAGTACCAACTGCATCATCTTTGAAATCAACAAATTTCTGATTGGT CTGGAACTGGTGCAGGAGCGACAGCTCCACCTGGAAACAAACATCTTGAAACTGGAGGATGACACGAACTGTTCCTTATCTTCAATCGAG GAAGACTTTCTCACCGCTTCTGAGCACTTGGAGGAGGAAAGCGAGGTGGATGAATCTAGGAACGATTATGAAAATATAAATGTCTCAGCC AATGTTTTGGAAAGTAAACAGCTAAAGGGAGCCACCCAGGTGGAATGGAATTGCAACAAGGAAAAGTGGCTTTATGCTTTGGAAGACAAA TACATCAACAAATATCCCACACCATTGATTAAAACAGAACGATCTCCAGAAAACCTAACAAAGAACACAGCCTTGCAGAGTCTAGATCCC TCAGCCAAGCCATCACAGTGGAAAAGAGAAGCTGTGGGGAATGGGAGACAAGCCACACATTATTATCATTCAGAAGCTTTTAAAGGTCAA ATGGAAAAATCACAGGCACTGTATATTCCAAAAGATGCTTATTTCTCCATGATGGATAAAGATGTACCTTCTGCATGTGCTGTGGCAGAG CAGAGAAGCAACCTAAACCCAGGAGACCATGAAGACACAAGAAACGCTCTCCCTCCTAGACAAGATGGAGAAGTCACCACTGGCAAGTAT GCTACAAATTTAGCAGAATCCGTGCTGCAGGATGCATTTATTAGATTATCTCAATCTCAGTCCACATTACCCCAGGAATCTGCAGTCAGT GTTTCTGTAGGAAGTTCTCTGCTTCCCAGTTGCTATTCCACAAAAGATACAGTGGTTTCTCGGTCATGGAATGAGCTCCCCAAAATCGTC GTTGTTCAGAGTCCAGATGGCAGTGATGCTGCCCCACAGCCAGGCATCTCCTCCTGGCCTGAGATGGAAGTCTCTGTTGAAACCTCAAGC ATCCTCTCTGGAGAGAACTCCAGCAGACAACCCCAGAGTGCTCTAGAAGTGGCGTTAGCTTGTGCAGCCACTGTGATTGGAACTATTTCC AGTCCACAGGCCACAGAAAGACTCAAAATGGAGCAAGTGGTCTCGAACTTTCCCCCAGGGAGCAGTGGTGCACTGCAAACTCAAGCACCC CAAGGACTCAAGGAACCTTCCATCAATGAGTACTCCTTTCCATCTGCTTTGTGTGGCATGACTCAGGTGGCCAGTGCCGTGGCTGTCTGT GGTCTGGGTGAAAGAGAAGAGGTGACATGCTCAGTGGCTCCAAGTGGTAGCCTCCCGCCTGCAGCTGAGGCTTCTGAAGCCATGCCCCCA CTTTGTGGTTTAGCAAGCATGGAGCTTGGCAAGGAAGCCATTGCCAAGGGATTGCTCAAGGAGGCTGCTCTGGTTTTAACAAGGCCTAAT ACCTACAGCAGCATTGGAGACTTTCTGGACTCCATGAACAGGAGAATCATGGAAACTGCTTCAAAGTCTCAGACCCTGTGCTCAGAAAAT GTCGTCAGGAATGAACTGGCACATACCCTGTCCAATGTTATCCTGAGGCATTCCATTGATGAAGTTCACCACAAAAATATGATAATCGAC CCCAATGACAACAGGCATTCATCTGAAATTCTGGACACCTTAATGGAAAGTACAAATCAACTGCTTTTAGATGTGATATGCTTCACGTTC AAGAAGATGAGTCATATTGTACGGCTTGGTGAATGTCCTGCTGTCCTTTCTAAGGAGACCATCAGAAGGAGGGAGACAGAACCAAGCTGC CAGCCATCTGATCCGGGTGCTAGTCAAGCTTGGACAAAAGCCACTGAATCCTCCAGCAGCTCTCCACTTAGCAATTCACACAACACGAGT CTTGTCATCAACAATCTTGTGGATGGCATGTATTCAAAACAAGACAAGGGTGGAGTGAGGCCAGGCCTCTTCAAGAACCCCACGCTGCAG TCACAATTATCACGTAGTCACAGAGTGCCCGATTCTTCAACTGCTACAACATCCTCCAAGGAAATATATCTGAAAGGAATAGCAGGAGAG GATACAAAAAGCCCTCATCACAGTGAGAATGAATGCAGAGCCTCTTCCGAAGGACAAAGGTCCCCAACGGTCAGCCAGTCCAGAAGTGGT TCCCAGGAGGCTGAGGAGAGTATCCACCCAAACACCCAAGAAAAGTACAACTGTGCCACATCTCGCATCAACGAAGTTCAAGTCAACCTG TCCTTGTTAGGGGATGACCTGCTGCTTCCTGCTCAATCCACGCTTCAAACAAAGCATCCAGACATCTACTGCATTACAGACTTTGCGGAA GAATTAGCAGACACGGTCGTCTCCATGGCAACTGAAATTGCAGCGATTTGCCTTGACAACTCCAGTGGAAAACAACCCTGGTTTTGTGCA TGGAAAAGAGGGAGTGAGTTTCTGATGACACCCAACGTACCCTGCCGATCCTTGAAGAGGAAGAAAGAGAGCCAGGGGAGCGGGACCGCT GTGAGGAAACACAAGCCTCCCCGGCTCAGTGAGATCAAGAGGAAGACGGACGAGCACCCTGAGCTTAAAGAAAAGCTGATGAACAGGGTT GTGGATGAGTCCATGAACCTTGAAGATGTCCCAGATTCTGTCAATCTTTTTGCCAATGAAGTGGCAGCCAAGATCATGAACCTAACGGAG TTCTCTATGGTGGACGGCATGTGGCAGGCGCAGGGCTATCCCCGGAATCGGTTACTGAGTGGCGACAGGTGGAGCCGGCTGAAGGCCTCC AGCTGCGAAAGCATTCCTGAGGAAGACTCCGAGGCCAGGGCCTATGTCAACAGCCTGGGCTTAATGAGCACGCTGAGCCAGCCGGTCAGC AGGGCCAGCTCTGTCTCCAAGCAGTCGAGCTGTGAGAGCATCACCGATGAGTTTTCCAGGTTCATGGTGAACCAGATGGAAAATGAAGGG AGAGGATTTGAGTTACTGCTGGATTACTATGCTGGCAAGAACGCCAGCAGCATTCTGAACTCAGCCATGCAACAGGCGTGCCGGAAAAGT GACCACCTCAGTGTGAGGCCTAGCTGTCCCTCTAAGCAGTCCAGCACAGAGAGCATCACTGAGGAGTTCTACAGGTACATGCTGAGGGAC ATCGAAAGAGACAGCAGAGAAAGTGCCTCCTCCAGACGGAGCAGCCAGGATTGGACAGCCGGCCTGCTGTCTCCTTCTCTGCGATCCCCA GTGTGCCACAGACAGTCGTCCATGCCAGACAGCAGATCCCCATGCTCCAGGCTGACAGTGAATGTGCCCATCAAAGCCAACTCTTTAGAT GGCTTTGCTCAGAACTGCCCACAAGATTTCCTAAGCGTGCAGCCGGTCAGTAGCGCGTCCTCATCCGGTCTCTGCAAATCTGACTCTTGC TTGTATCGGAGAGGTGGGACTGACCACATCACCAACATGTTAATTCATGAAACGTGGGCTAGCTCCATTGAGGCTCTCATGCGCAAGAAC AAAATCATTGTGGATGATGCAGAGGAAGCTGACACTGAGCCTGTTTCTGGTGGCTCTCCCTCGCAAGCAGAGAAGTGTGCAAATAGATTA GCTGCGAGCAGGATGTGCAGTGGGCCAACTCTGCTTGTTCAGGAGTCTCTCGATTGCCCGAGGAAAGACTCTGTTACCGAATGTAAACAG CCCCCAGTGTCATCTTTGAGCAAAACTGCTTCTCTTACAAACCACAGCCCTTTAGATTCTAAAAAAGAAACTTCCTCGTGCCAGGACCCT GTACCAATAAACCACAAAAGGCGATCACTTTGCTCGAGGGAAGTGCCTTTGATTCAGATTGAAACAGATCAGAGAGAAGCCTGTGCTGGG GAACCTGAACCCTTCCTTTCCAAAAGCAGCCTCCTAGAGGAAGCAGAAGGGCATTCGAATGACAAAAACATCCCAGATGTGGTGAGAGGT GGAGACACAGCCGTGAGCGCTTGTCAAATCCATAGTGACAGCCTTGATACCAGAGATGTACCAGAGGCTGAAGCCTCCACAGAAGCCAGA GCCCCCGATGAGGCCCCCAACCCTCCAAGCAGCAGCGAGGAGAGCACAGGCAGCTGGACCCAGCTTGCCAATGAGGAAGACAACCCAGAT GACACAAGTAGCTTTCTCCAGCTCAGTGAGCGATCCATGAGTGAATTAGTAGAAGAAAAGAAGATTCTTAAAGGACAGTCAGAAAGCACA GAGGCACCTGCATCTGGACCGCCTACGGGAACAGCCAGCCCCCAGAGGAGCCTGCTGGTGATCAACTTTGACCTGGAGCCAGAGTGTCCA GATGCCGAGCTCCGAGCCACTCTGCAGTGGATAGCTGCCTCTGAACTGGGGATTCCCACCATCTACTTTAAGAAATCTCAGGAAAACAGA ATTGAAAAGTTTCTAGATGTCGTGCAGCTGGTTCATCGGAAGTCCTGGAAAGTGGGTGATATCTTCCATGCAGTTGTCCAGTACTGCAAA ATGCATGAGGAGCAGAAGGATGGGAGACTGAGTCTCTTTGACTGGCTCTTGGAACTGGGATAATAAGGCAGTCTGCCGTATAGATCATTC CTTCCCTTTATTCCAACTTAGATTACAGTGGTTTGTTCTAAATGCTCTAAACATTCTCAAAACATCACATCACATTAGCAGAACTATAAA AAAAAATCTGCTACTCAGATCCACTGCATACAGAATAAGTCAGAGGAAAAGCAAAATATAGGTCTGTCCAAATTCATACAACTTGTGGGT GAGTTCCAAAGAGCTTGGATTAGAAGGGCTGGACAAAGAGAGAATTCAATGGGGCCCAAATTAGAATGCTTATAATGAGACCCAATCTCC AGGAAAACAACACTCACATAAGTTTAATCATATAAAATGATTTGTAATGTCTCTAATTAGATGAATCAACTAGAAACAAACTCAGTGGTC AAAATAATTTTTAAGAGTATTCCGTAACCTATATTTTACTTTTCTGATTATATTAAGGGGCTGCCAGCCCGGAGAAATACTTAAGATATG GGTGAGAAATCCCCAGACTTTTATACAAAAGATTTCCACTTTCAAATCAATGTCAGTAGACATTGATAAAAGTATAGCAGCATCCTCTAC TGAGGTGATTTCATTTATTCCCTGCAGCCCACTGATAAATATCTCACTTCTCCCAAATAGTATGTGGACTCCCAGCTAAGCAGAAAACTA TTGTCATTCAACTGAAGAAGAGGAAGATAAAAGATTGTCTTGTTTCCATCACTGTATTACTTGTGTAACATGATTACATAATTCTTATCC TAAGAGAAAGCTTTCATATTTAAAAAAAAGTCTTTTCAGATAAAATCTGCTTGTGTCTTGAATAATATGAAATACAAACTTTCACTTTAT TTTATTGTAAATTATAAAGAGATTATTGTCTTAAATAATATATTGAGTTAGCTTCAAGCTTCCTAAAATATGAAGAGATTGTTGTCTAAA GTCACATATTGACATTGAGCTCAGTGGCCTGTTTCATCACGTATGTGCTGCTACCTGTACAGCAGACATGCCGCTCCAGTGACATTTATA ATGACAGAAGCAGGGTAATGGTCTTGTGTTTGACATGATCAGTTAGGATCATAGACTTTCCCTGACTCGTAGATATTAGCCTTGAATTGG GGGAAAAGAAGACTTTGACACATTTTAGTTATTTTAATAACAGAGATTTACTCTTTTGAAAAATAAAGGTATCTAATGTCTCCCTAATAA GTCTTCTTTCCTTCCAACTAAATGACCTACACGGACTTTTATTTTCTTGATCAAAGAGGTGTTTATTAAGGACTTCTGGATAACTATACT TTTACTCTATTTTTAAAGATCACAAAGTAATTTTAAATGTGAACAGGTTCCCATACCATGAATGCTGGCCTCACCTTCTCTATCATCCAC ATTTTGAAATGCAAAGAAAGCTCCCTTGTAAGCCATACTTCCTTCCCCACTCCCATCCTAGGATACTTGCCCAGTGCTCATTAGGCATTT CTTATTCAGATAGTCCAAATTTAGGTTATTATGCTTAATTTGACACATTAACTAAATGCCCAGTTTTAAAATATATCCATCAATTCACGC TGAAATGTGCTTCTTTGTGCTATCAAATGGAATAGAATACACTTATTTTTTAAACAATCCCAGAATACTGTGTGTAGACTTTTGTTGTGC TCAAATAAATGTTTACTTATCTTACAAAGCTCAAATACTGGATTGTAACCATGTGATGAAGTTATCTATGTTGTACCTAACATTGCAAAT >22914_22914_3_DIS3L2-SPHKAP_DIS3L2_chr2_233164829_ENST00000409307_SPHKAP_chr2_228996801_ENST00000344657_length(amino acids)=2240AA_BP=578 MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP WTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQKVVPMLPRLLCE ELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQAVLNLHGIAKQLR QQRFVDGALRLDQLKLAFTLDHETGLPQGCHIYEYRESNNNLESSRMYDVLEPQQGRGCGSSGSGPGNSITACKKVLRSNSLLESTDYWL QNQRMPCQIGFVEDKSENCASVCFVNLDVNKDECSTEHLQQKLVNVSPDLPKLISSMNVQQPKENEIVVLSGLASGNLQADFEVSQCPWL PDICLVQCARGNRPNSTNCIIFEINKFLIGLELVQERQLHLETNILKLEDDTNCSLSSIEEDFLTASEHLEEESEVDESRNDYENINVSA NVLESKQLKGATQVEWNCNKEKWLYALEDKYINKYPTPLIKTERSPENLTKNTALQSLDPSAKPSQWKREAVGNGRQATHYYHSEAFKGQ MEKSQALYIPKDAYFSMMDKDVPSACAVAEQRSNLNPGDHEDTRNALPPRQDGEVTTGKYATNLAESVLQDAFIRLSQSQSTLPQESAVS VSVGSSLLPSCYSTKDTVVSRSWNELPKIVVVQSPDGSDAAPQPGISSWPEMEVSVETSSILSGENSSRQPQSALEVALACAATVIGTIS SPQATERLKMEQVVSNFPPGSSGALQTQAPQGLKEPSINEYSFPSALCGMTQVASAVAVCGLGEREEVTCSVAPSGSLPPAAEASEAMPP LCGLASMELGKEAIAKGLLKEAALVLTRPNTYSSIGDFLDSMNRRIMETASKSQTLCSENVVRNELAHTLSNVILRHSIDEVHHKNMIID PNDNRHSSEILDTLMESTNQLLLDVICFTFKKMSHIVRLGECPAVLSKETIRRRETEPSCQPSDPGASQAWTKATESSSSSPLSNSHNTS LVINNLVDGMYSKQDKGGVRPGLFKNPTLQSQLSRSHRVPDSSTATTSSKEIYLKGIAGEDTKSPHHSENECRASSEGQRSPTVSQSRSG SQEAEESIHPNTQEKYNCATSRINEVQVNLSLLGDDLLLPAQSTLQTKHPDIYCITDFAEELADTVVSMATEIAAICLDNSSGKQPWFCA WKRGSEFLMTPNVPCRSLKRKKESQGSGTAVRKHKPPRLSEIKRKTDEHPELKEKLMNRVVDESMNLEDVPDSVNLFANEVAAKIMNLTE FSMVDGMWQAQGYPRNRLLSGDRWSRLKASSCESIPEEDSEARAYVNSLGLMSTLSQPVSRASSVSKQSSCESITDEFSRFMVNQMENEG RGFELLLDYYAGKNASSILNSAMQQACRKSDHLSVRPSCPSKQSSTESITEEFYRYMLRDIERDSRESASSRRSSQDWTAGLLSPSLRSP VCHRQSSMPDSRSPCSRLTVNVPIKANSLDGFAQNCPQDFLSVQPVSSASSSGLCKSDSCLYRRGGTDHITNMLIHETWASSIEALMRKN KIIVDDAEEADTEPVSGGSPSQAEKCANRLAASRMCSGPTLLVQESLDCPRKDSVTECKQPPVSSLSKTASLTNHSPLDSKKETSSCQDP VPINHKRRSLCSREVPLIQIETDQREACAGEPEPFLSKSSLLEEAEGHSNDKNIPDVVRGGDTAVSACQIHSDSLDTRDVPEAEASTEAR APDEAPNPPSSSEESTGSWTQLANEEDNPDDTSSFLQLSERSMSELVEEKKILKGQSESTEAPASGPPTGTASPQRSLLVINFDLEPECP -------------------------------------------------------------- >22914_22914_4_DIS3L2-SPHKAP_DIS3L2_chr2_233164829_ENST00000409307_SPHKAP_chr2_228996801_ENST00000392056_length(transcript)=8577nt_BP=1739nt ATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCT TCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCA GAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGT GATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCAT TGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTC CCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGC ATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACA AAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAG AAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCC TCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTG TTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAG CCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCA TGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGAAAAGACTGTATCTTCACCATTGACCCATCAACCGCCCGAGACCTC GATGATGCCCTCTCCTGCAAGCCACTCGCTGACGGCAACTTCAAAGTGGGAGTTCACATTGCTGACGTGAGTTACTTTGTTCCGGAGGGA TCTGATCTGGATAAAGTGGCTGCCGAGAGGGCTACAAGCGTCTACTTGGTTCAAAAGGTGGTCCCCATGCTTCCCAGGCTGCTGTGTGAG GAGCTGTGCAGCCTCAACCCCATGTCCGACAAGCTGACCTTCTCTGTGATCTGGACACTGACTCCAGAGGGCAAGATCCTTGATGAATGG TTTGGCCGGACCATCATCCGCTCCTGCACCAAACTTAGCTACGAGCATGCACAGAGCATGATTGAAAGCCCAACTGAGAAAATCCCTGCG AAAGAGCTGCCCCCCATTTCCCCAGAGCATAGCAGCGAGGAGGTACACCAGGCCGTCTTGAATCTCCACGGAATTGCCAAGCAGTTACGC CAGCAGCGCTTTGTGGACGGCGCACTTCGTTTGGATCAGCTAAAGCTTGCTTTCACTCTGGACCACGAGACCGGATTGCCTCAAGGATGT CATATCTATGAGTACCGCGAGAGCAACAACAACTTGGAGTCATCACGGATGTATGACGTTTTGGAACCGCAGCAGGGCAGAGGCTGTGGC AGCTCAGGAAGCGGCCCGGGGAACTCCATCACAGCCTGTAAGAAGGTTCTTCGCAGCAATAGCCTGCTGGAGTCAACAGACTACTGGTTG CAGAATCAGAGGATGCCCTGCCAAATTGGTTTTGTAGAAGACAAGTCTGAAAACTGTGCTTCTGTCTGCTTTGTGAATCTTGATGTGAAC AAGGATGAATGCAGCACAGAGCACCTGCAACAGAAACTGGTCAACGTTTCACCAGATCTTCCAAAACTTATCAGTTCCATGAATGTCCAA CAACCAAAAGAAAATGAAATTGTTGTCCTAAGTGGGTTAGCCTCTGGAAATCTCCAGGCAGATTTTGAAGTTTCACAGTGCCCTTGGCTG CCAGATATCTGCTTGGTCCAATGTGCAAGAGGGAACAGACCAAACAGTACCAACTGCATCATCTTTGAAATCAACAAATTTCTGATTGGT CTGGAACTGGTGCAGGAGCGACAGCTCCACCTGGAAACAAACATCTTGAAACTGGAGGATGACACGAACTGTTCCTTATCTTCAATCGAG GAAGACTTTCTCACCGCTTCTGAGCACTTGGAGGAGGAAAGCGAGGTGGATGAATCTAGGAACGATTATGAAAATATAAATGTCTCAGCC AATGTTTTGGAAAGTAAACAGCTAAAGGGAGCCACCCAGGTGGAATGGAATTGCAACAAGGAAAAGTGGCTTTATGCTTTGGAAGACAAA TACATCAACAAATATCCCACACCATTGATTAAAACAGAACGATCTCCAGAAAACCTAACAAAGAACACAGCCTTGCAGAGTCTAGATCCC TCAGCCAAGCCATCACAGTGGAAAAGAGAAGCTGTGGGGAATGGGAGACAAGCCACACATTATTATCATTCAGAAGCTTTTAAAGGTCAA ATGGAAAAATCACAGGCACTGTATATTCCAAAAGATGCTTATTTCTCCATGATGGATAAAGATGTACCTTCTGCATGTGCTGTGGCAGAG CAGAGAAGCAACCTAAACCCAGGAGACCATGAAGACACAAGAAACGCTCTCCCTCCTAGACAAGATGGAGAAGTCACCACTGGCAAGTAT GCTACAAATTTAGCAGAATCCGTGCTGCAGGATGCATTTATTAGATTATCTCAATCTCAGTCCACATTACCCCAGGAATCTGCAGTCAGT GTTTCTGTAGGAAGTTCTCTGCTTCCCAGTTGCTATTCCACAAAAGATACAGTGGTTTCTCGGTCATGGAATGAGCTCCCCAAAATCGTC GTTGTTCAGAGTCCAGATGGCAGTGATGCTGCCCCACAGCCAGGCATCTCCTCCTGGCCTGAGATGGAAGTCTCTGTTGAAACCTCAAGC ATCCTCTCTGGAGAGAACTCCAGCAGACAACCCCAGAGTGCTCTAGAAGTGGCGTTAGCTTGTGCAGCCACTGTGATTGGAACTATTTCC AGTCCACAGGCCACAGAAAGACTCAAAATGGAGCAAGTGGTCTCGAACTTTCCCCCAGGGAGCAGTGGTGCACTGCAAACTCAAGCACCC CAAGGACTCAAGGAACCTTCCATCAATGAGTACTCCTTTCCATCTGCTTTGTGTGGCATGACTCAGGTGGCCAGTGCCGTGGCTGTCTGT GGTCTGGGTGAAAGAGAAGAGGTGACATGCTCAGTGGCTCCAAGTGGTAGCCTCCCGCCTGCAGCTGAGGCTTCTGAAGCCATGCCCCCA CTTTGTGGTTTAGCAAGCATGGAGCTTGGCAAGGAAGCCATTGCCAAGGGATTGCTCAAGGAGGCTGCTCTGGTTTTAACAAGGCCTAAT ACCTACAGCAGCATTGGAGACTTTCTGGACTCCATGAACAGGAGAATCATGGAAACTGCTTCAAAGTCTCAGACCCTGTGCTCAGAAAAT GTCGTCAGGAATGAACTGGCACATACCCTGTCCAATGTTATCCTGAGGCATTCCATTGATGAAGTTCACCACAAAAATATGATAATCGAC CCCAATGACAACAGGCATTCATCTGAAATTCTGGACACCTTAATGGAAAGTACAAATCAACTGCTTTTAGATGTGATATGCTTCACGTTC AAGAAGATGAGTCATATTGTACGGCTTGGTGAATGTCCTGCTGTCCTTTCTAAGGAGACCATCAGAAGGAGGGAGACAGAACCAAGCTGC CAGCCATCTGATCCGGGTGCTAGTCAAGCTTGGACAAAAGCCACTGAATCCTCCAGCAGCTCTCCACTTAGCAATTCACACAACACGAGT CTTGTCATCAACAATCTTGTGGATGGCATGTATTCAAAACAAGACAAGGGTGGAGTGAGGCCAGGCCTCTTCAAGAACCCCACGCTGCAG TCACAATTATCACGTAGTCACAGAGTGCCCGATTCTTCAACTGCTACAACATCCTCCAAGGAAATATATCTGAAAGGAATAGCAGGAGAG GATACAAAAAGCCCTCATCACAGTGAGAATGAATGCAGAGCCTCTTCCGAAGGACAAAGGTCCCCAACGGTCAGCCAGTCCAGAAGTGGT TCCCAGGAGGCTGAGGAGAGTATCCACCCAAACACCCAAGAAAAGTACAACTGTGCCACATCTCGCATCAACGAAGTTCAAGTCAACCTG TCCTTGTTAGGGGATGACCTGCTGCTTCCTGCTCAATCCACGCTTCAAACAAAGCATCCAGACATCTACTGCATTACAGACTTTGCGGAA GAATTAGCAGACACGGTCGTCTCCATGGCAACTGAAATTGCAGCGATTTGCCTTGACAACTCCAGTGGAAAACAACCCTGGTTTTGTGCA TGGAAAAGAGGGAGTGAGTTTCTGATGACACCCAACGTACCCTGCCGATCCTTGAAGAGGAAGAAAGAGAGCCAGGGGAGCGGGACCGCT GTGAGGAAACACAAGCCTCCCCGGCTCAGTGAGATCAAGAGGAAGACGGACGAGCACCCTGAGCTTAAAGAAAAGCTGATGAACAGGGTT GTGGATGAGTCCATGAACCTTGAAGATGTCCCAGATTCTGTCAATCTTTTTGCCAATGAAGTGGCAGCCAAGATCATGAACCTAACGGAG TTCTCTATGGTGGACGGCATGTGGCAGGCGCAGGGCTATCCCCGGAATCGGTTACTGAGTGGCGACAGGTGGAGCCGGCTGAAGGCCTCC AGCTGCGAAAGCATTCCTGAGGAAGACTCCGAGGCCAGGGCCTATGTCAACAGCCTGGGCTTAATGAGCACGCTGAGCCAGCCGGTCAGC AGGGCCAGCTCTGTCTCCAAGCAGTCGAGCTGTGAGAGCATCACCGATGAGTTTTCCAGGTTCATGGTGAACCAGATGGAAAATGAAGGG AGAGGATTTGAGTTACTGCTGGATTACTATGCTGGCAAGAACGCCAGCAGCATTCTGAACTCAGCCATGCAACAGGCGTGCCGGAAAAGT GACCACCTCAGTGTGAGGCCTAGCTGTCCCTCTAAGCAGTCCAGCACAGAGAGCATCACTGAGGAGTTCTACAGGTACATGCTGAGGGAC ATCGAAAGAGACAGCAGAGAAAGTGCCTCCTCCAGACGGAGCAGCCAGGATTGGACAGCCGGCCTGCTGTCTCCTTCTCTGCGATCCCCA GTGTGCCACAGACAGTCGTCCATGCCAGACAGCAGATCCCCATGCTCCAGGCTGACAGTGAATGTGCCCATCAAAGCCAACTCTTTAGAT GGCTTTGCTCAGAACTGCCCACAAGATTTCCTAAGCGTGCAGCCGGTCAGTAGCGCGTCCTCATCCGGTCTCTGCAAATCTGACTCTTGC TTGTATCGGAGAGGTGGGACTGACCACATCACCAACATGTTAATTCATGAAACGTGGGCTAGCTCCATTGAGGCTCTCATGCGCAAGAAC AAAATCATTGTGGATGATGCAGAGGAAGCTGACACTGAGCCTGTTTCTGGTGGCTCTCCCTCGCAAGCAGAGAAGTGTGCAAATAGATTA GCTGCGAGCAGGATGTGCAGTGGGCCAACTCTGCTTGTTCAGGAGTCTCTCGATTGCCCGAGGAAAGACTCTGTTACCGAATGTAAACAG CCCCCAGTGTCATCTTTGAGCAAAACTGCTTCTCTTACAAACCACAGCCCTTTAGATTCTAAAAAAGAAACTTCCTCGTGCCAGGACCCT GTACCAATAAACCACAAAAGGCGATCACTTTGCTCGAGGGAAGTGCCTTTGATTCAGATTGAAACAGATCAGAGAGAAGCCTGTGCTGGG GAACCTGAACCCTTCCTTTCCAAAAGCAGCCTCCTAGAGGAAGCAGAAGGGCATTCGAATGACAAAAACATCCCAGATGTGGTGAGAGGT GGAGACACAGCCGTGAGCGCTTGTCAAATCCATAGTGACAGCCTTGATACCAGAGATGTACCAGAGGCTGAAGCCTCCACAGAAGCCAGA GCCCCCGATGAGGCCCCCAACCCTCCAAGCAGCAGCGAGGAGAGCACAGGCAGCTGGACCCAGCTTGCCAATGAGGAAGACAACCCAGAT GACACAAGTAGCTTTCTCCAGCTCAGTGAGCGATCCATGAGCAATGGCAACAGTAGTGCCACTAGCAGTCTTGGCATTATGGATCTGGAC ATTTATCAGGAAAGCATGCCATCTTCTCCCATGATTAATGAATTAGTAGAAGAAAAGAAGATTCTTAAAGGACAGTCAGAAAGCACAGAG GCACCTGCATCTGGACCGCCTACGGGAACAGCCAGCCCCCAGAGGAGCCTGCTGGTGATCAACTTTGACCTGGAGCCAGAGTGTCCAGAT GCCGAGCTCCGAGCCACTCTGCAGTGGATAGCTGCCTCTGAACTGGGGATTCCCACCATCTACTTTAAGAAATCTCAGGAAAACAGAATT GAAAAGTTTCTAGATGTCGTGCAGCTGGTTCATCGGAAGTCCTGGAAAGTGGGTGATATCTTCCATGCAGTTGTCCAGTACTGCAAAATG CATGAGGAGCAGAAGGATGGGAGACTGAGTCTCTTTGACTGGCTCTTGGAACTGGGATAATAAGGCAGTCTGCCGTATAGATCATTCCTT CCCTTTATTCCAACTTAGATTACAGTGGTTTGTTCTAAATGCTCTAAACATTCTCAAAACATCACATCACATTAGCAGAACTATAAAAAA AAATCTGCTACTCAGATCCACTGCATACAGAATAAGTCAGAGGAAAAGCAAAATATAGGTCTGTCCAAATTCATACAACTTGTGGGTGAG TTCCAAAGAGCTTGGATTAGAAGGGCTGGACAAAGAGAGAATTCAATGGGGCCCAAATTAGAATGCTTATAATGAGACCCAATCTCCAGG AAAACAACACTCACATAAGTTTAATCATATAAAATGATTTGTAATGTCTCTAATTAGATGAATCAACTAGAAACAAACTCAGTGGTCAAA ATAATTTTTAAGAGTATTCCGTAACCTATATTTTACTTTTCTGATTATATTAAGGGGCTGCCAGCCCGGAGAAATACTTAAGATATGGGT GAGAAATCCCCAGACTTTTATACAAAAGATTTCCACTTTCAAATCAATGTCAGTAGACATTGATAAAAGTATAGCAGCATCCTCTACTGA GGTGATTTCATTTATTCCCTGCAGCCCACTGATAAATATCTCACTTCTCCCAAATAGTATGTGGACTCCCAGCTAAGCAGAAAACTATTG TCATTCAACTGAAGAAGAGGAAGATAAAAGATTGTCTTGTTTCCATCACTGTATTACTTGTGTAACATGATTACATAATTCTTATCCTAA GAGAAAGCTTTCATATTTAAAAAAAAGTCTTTTCAGATAAAATCTGCTTGTGTCTTGAATAATATGAAATACAAACTTTCACTTTATTTT ATTGTAAATTATAAAGAGATTATTGTCTTAAATAATATATTGAGTTAGCTTCAAGCTTCCTAAAATATGAAGAGATTGTTGTCTAAAGTC ACATATTGACATTGAGCTCAGTGGCCTGTTTCATCACGTATGTGCTGCTACCTGTACAGCAGACATGCCGCTCCAGTGACATTTATAATG ACAGAAGCAGGGTAATGGTCTTGTGTTTGACATGATCAGTTAGGATCATAGACTTTCCCTGACTCGTAGATATTAGCCTTGAATTGGGGG AAAAGAAGACTTTGACACATTTTAGTTATTTTAATAACAGAGATTTACTCTTTTGAAAAATAAAGGTATCTAATGTCTCCCTAATAAGTC TTCTTTCCTTCCAACTAAATGACCTACACGGACTTTTATTTTCTTGATCAAAGAGGTGTTTATTAAGGACTTCTGGATAACTATACTTTT ACTCTATTTTTAAAGATCACAAAGTAATTTTAAATGTGAACAGGTTCCCATACCATGAATGCTGGCCTCACCTTCTCTATCATCCACATT TTGAAATGCAAAGAAAGCTCCCTTGTAAGCCATACTTCCTTCCCCACTCCCATCCTAGGATACTTGCCCAGTGCTCATTAGGCATTTCTT ATTCAGATAGTCCAAATTTAGGTTATTATGCTTAATTTGACACATTAACTAAATGCCCAGTTTTAAAATATATCCATCAATTCACGCTGA AATGTGCTTCTTTGTGCTATCAAATGGAATAGAATACACTTATTTTTTAAACAATCCCAGAATACTGTGTGTAGACTTTTGTTGTGCTCA AATAAATGTTTACTTATCTTACAAAGCTCAAATACTGGATTGTAACCATGTGATGAAGTTATCTATGTTGTACCTAACATTGCAAATTAA >22914_22914_4_DIS3L2-SPHKAP_DIS3L2_chr2_233164829_ENST00000409307_SPHKAP_chr2_228996801_ENST00000392056_length(amino acids)=2269AA_BP=578 MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP WTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQKVVPMLPRLLCE ELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQAVLNLHGIAKQLR QQRFVDGALRLDQLKLAFTLDHETGLPQGCHIYEYRESNNNLESSRMYDVLEPQQGRGCGSSGSGPGNSITACKKVLRSNSLLESTDYWL QNQRMPCQIGFVEDKSENCASVCFVNLDVNKDECSTEHLQQKLVNVSPDLPKLISSMNVQQPKENEIVVLSGLASGNLQADFEVSQCPWL PDICLVQCARGNRPNSTNCIIFEINKFLIGLELVQERQLHLETNILKLEDDTNCSLSSIEEDFLTASEHLEEESEVDESRNDYENINVSA NVLESKQLKGATQVEWNCNKEKWLYALEDKYINKYPTPLIKTERSPENLTKNTALQSLDPSAKPSQWKREAVGNGRQATHYYHSEAFKGQ MEKSQALYIPKDAYFSMMDKDVPSACAVAEQRSNLNPGDHEDTRNALPPRQDGEVTTGKYATNLAESVLQDAFIRLSQSQSTLPQESAVS VSVGSSLLPSCYSTKDTVVSRSWNELPKIVVVQSPDGSDAAPQPGISSWPEMEVSVETSSILSGENSSRQPQSALEVALACAATVIGTIS SPQATERLKMEQVVSNFPPGSSGALQTQAPQGLKEPSINEYSFPSALCGMTQVASAVAVCGLGEREEVTCSVAPSGSLPPAAEASEAMPP LCGLASMELGKEAIAKGLLKEAALVLTRPNTYSSIGDFLDSMNRRIMETASKSQTLCSENVVRNELAHTLSNVILRHSIDEVHHKNMIID PNDNRHSSEILDTLMESTNQLLLDVICFTFKKMSHIVRLGECPAVLSKETIRRRETEPSCQPSDPGASQAWTKATESSSSSPLSNSHNTS LVINNLVDGMYSKQDKGGVRPGLFKNPTLQSQLSRSHRVPDSSTATTSSKEIYLKGIAGEDTKSPHHSENECRASSEGQRSPTVSQSRSG SQEAEESIHPNTQEKYNCATSRINEVQVNLSLLGDDLLLPAQSTLQTKHPDIYCITDFAEELADTVVSMATEIAAICLDNSSGKQPWFCA WKRGSEFLMTPNVPCRSLKRKKESQGSGTAVRKHKPPRLSEIKRKTDEHPELKEKLMNRVVDESMNLEDVPDSVNLFANEVAAKIMNLTE FSMVDGMWQAQGYPRNRLLSGDRWSRLKASSCESIPEEDSEARAYVNSLGLMSTLSQPVSRASSVSKQSSCESITDEFSRFMVNQMENEG RGFELLLDYYAGKNASSILNSAMQQACRKSDHLSVRPSCPSKQSSTESITEEFYRYMLRDIERDSRESASSRRSSQDWTAGLLSPSLRSP VCHRQSSMPDSRSPCSRLTVNVPIKANSLDGFAQNCPQDFLSVQPVSSASSSGLCKSDSCLYRRGGTDHITNMLIHETWASSIEALMRKN KIIVDDAEEADTEPVSGGSPSQAEKCANRLAASRMCSGPTLLVQESLDCPRKDSVTECKQPPVSSLSKTASLTNHSPLDSKKETSSCQDP VPINHKRRSLCSREVPLIQIETDQREACAGEPEPFLSKSSLLEEAEGHSNDKNIPDVVRGGDTAVSACQIHSDSLDTRDVPEAEASTEAR APDEAPNPPSSSEESTGSWTQLANEEDNPDDTSSFLQLSERSMSNGNSSATSSLGIMDLDIYQESMPSSPMINELVEEKKILKGQSESTE APASGPPTGTASPQRSLLVINFDLEPECPDAELRATLQWIAASELGIPTIYFKKSQENRIEKFLDVVQLVHRKSWKVGDIFHAVVQYCKM -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for DIS3L2-SPHKAP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DIS3L2-SPHKAP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DIS3L2-SPHKAP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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