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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DIS3L2-WDR75 (FusionGDB2 ID:22925)

Fusion Gene Summary for DIS3L2-WDR75

check button Fusion gene summary
Fusion gene informationFusion gene name: DIS3L2-WDR75
Fusion gene ID: 22925
HgeneTgene
Gene symbol

DIS3L2

WDR75

Gene ID

129563

84128

Gene nameDIS3 like 3'-5' exoribonuclease 2WD repeat domain 75
SynonymsFAM6A|PRLMNS|hDIS3L2NET16|UTP17
Cytomap

2q37.1

2q32.2

Type of geneprotein-codingprotein-coding
DescriptionDIS3-like exonuclease 2DIS3 mitotic control homolog-like 2family with sequence similarity 6, member AWD repeat-containing protein 75U3 small nucleolar RNA-associated protein 17 homologUTP17, small subunit (SSU) processome component, homolog
Modification date2020031320200313
UniProtAcc

Q8IYB7

.
Ensembl transtripts involved in fusion geneENST00000273009, ENST00000325385, 
ENST00000409307, ENST00000360410, 
ENST00000409401, ENST00000470087, 
ENST00000314761, 
Fusion gene scores* DoF score27 X 9 X 12=29164 X 4 X 2=32
# samples 255
** MAII scorelog2(25/2916*10)=-3.54399071966485
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/32*10)=0.643856189774725
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DIS3L2 [Title/Abstract] AND WDR75 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDIS3L2(233028342)-WDR75(190313104), # samples:1
DIS3L2(233028342)-WDR75(190313105), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDIS3L2

GO:0010587

miRNA catabolic process

24141620


check buttonFusion gene breakpoints across DIS3L2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across WDR75 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4J9-01ADIS3L2chr2

233028342

+WDR75chr2

190313105

+
ChimerDB4STADTCGA-BR-A4J9DIS3L2chr2

233028342

+WDR75chr2

190313104

+


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Fusion Gene ORF analysis for DIS3L2-WDR75

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000273009ENST00000314761DIS3L2chr2

233028342

+WDR75chr2

190313105

+
In-frameENST00000273009ENST00000314761DIS3L2chr2

233028342

+WDR75chr2

190313104

+
In-frameENST00000325385ENST00000314761DIS3L2chr2

233028342

+WDR75chr2

190313105

+
In-frameENST00000325385ENST00000314761DIS3L2chr2

233028342

+WDR75chr2

190313104

+
In-frameENST00000409307ENST00000314761DIS3L2chr2

233028342

+WDR75chr2

190313105

+
In-frameENST00000409307ENST00000314761DIS3L2chr2

233028342

+WDR75chr2

190313104

+
intron-3CDSENST00000360410ENST00000314761DIS3L2chr2

233028342

+WDR75chr2

190313105

+
intron-3CDSENST00000360410ENST00000314761DIS3L2chr2

233028342

+WDR75chr2

190313104

+
intron-3CDSENST00000409401ENST00000314761DIS3L2chr2

233028342

+WDR75chr2

190313105

+
intron-3CDSENST00000409401ENST00000314761DIS3L2chr2

233028342

+WDR75chr2

190313104

+
intron-3CDSENST00000470087ENST00000314761DIS3L2chr2

233028342

+WDR75chr2

190313105

+
intron-3CDSENST00000470087ENST00000314761DIS3L2chr2

233028342

+WDR75chr2

190313104

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000273009DIS3L2chr2233028342+ENST00000314761WDR75chr2190313104+4293173857841441188
ENST00000325385DIS3L2chr2233028342+ENST00000314761WDR75chr2190313104+3955140024038061188
ENST00000409307DIS3L2chr2233028342+ENST00000314761WDR75chr2190313104+36791124035301176
ENST00000273009DIS3L2chr2233028342+ENST00000314761WDR75chr2190313105+4293173857841441188
ENST00000325385DIS3L2chr2233028342+ENST00000314761WDR75chr2190313105+3955140024038061188
ENST00000409307DIS3L2chr2233028342+ENST00000314761WDR75chr2190313105+36791124035301176

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000273009ENST00000314761DIS3L2chr2233028342+WDR75chr2190313104+0.0006031450.9993968
ENST00000325385ENST00000314761DIS3L2chr2233028342+WDR75chr2190313104+0.000356010.99964404
ENST00000409307ENST00000314761DIS3L2chr2233028342+WDR75chr2190313104+0.0002255740.9997744
ENST00000273009ENST00000314761DIS3L2chr2233028342+WDR75chr2190313105+0.0006031450.9993968
ENST00000325385ENST00000314761DIS3L2chr2233028342+WDR75chr2190313105+0.000356010.99964404
ENST00000409307ENST00000314761DIS3L2chr2233028342+WDR75chr2190313105+0.0002255740.9997744

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Fusion Genomic Features for DIS3L2-WDR75


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DIS3L2chr2233028342+WDR75chr2190313104+2.27E-060.99999774
DIS3L2chr2233028342+WDR75chr2190313104+2.27E-060.99999774
DIS3L2chr2233028342+WDR75chr2190313104+2.27E-060.99999774
DIS3L2chr2233028342+WDR75chr2190313104+2.27E-060.99999774

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DIS3L2-WDR75


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:233028342/chr2:190313104)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DIS3L2

Q8IYB7

.
FUNCTION: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. {ECO:0000255|HAMAP-Rule:MF_03045, ECO:0000269|PubMed:23756462, ECO:0000269|PubMed:24141620}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWDR75chr2:233028342chr2:190313104ENST00000314761021145_18428831.0RepeatNote=WD 4
TgeneWDR75chr2:233028342chr2:190313104ENST00000314761021193_23128831.0RepeatNote=WD 5
TgeneWDR75chr2:233028342chr2:190313104ENST00000314761021237_27628831.0RepeatNote=WD 6
TgeneWDR75chr2:233028342chr2:190313104ENST00000314761021279_31828831.0RepeatNote=WD 7
TgeneWDR75chr2:233028342chr2:190313104ENST00000314761021324_36228831.0RepeatNote=WD 8
TgeneWDR75chr2:233028342chr2:190313104ENST00000314761021376_42328831.0RepeatNote=WD 9
TgeneWDR75chr2:233028342chr2:190313104ENST00000314761021430_47428831.0RepeatNote=WD 10
TgeneWDR75chr2:233028342chr2:190313104ENST0000031476102147_8628831.0RepeatNote=WD 2
TgeneWDR75chr2:233028342chr2:190313104ENST00000314761021487_52528831.0RepeatNote=WD 11
TgeneWDR75chr2:233028342chr2:190313104ENST00000314761021529_56928831.0RepeatNote=WD 12
TgeneWDR75chr2:233028342chr2:190313104ENST00000314761021574_61128831.0RepeatNote=WD 13
TgeneWDR75chr2:233028342chr2:190313104ENST0000031476102190_13128831.0RepeatNote=WD 3
TgeneWDR75chr2:233028342chr2:190313105ENST00000314761021145_18428831.0RepeatNote=WD 4
TgeneWDR75chr2:233028342chr2:190313105ENST00000314761021193_23128831.0RepeatNote=WD 5
TgeneWDR75chr2:233028342chr2:190313105ENST00000314761021237_27628831.0RepeatNote=WD 6
TgeneWDR75chr2:233028342chr2:190313105ENST00000314761021279_31828831.0RepeatNote=WD 7
TgeneWDR75chr2:233028342chr2:190313105ENST00000314761021324_36228831.0RepeatNote=WD 8
TgeneWDR75chr2:233028342chr2:190313105ENST00000314761021376_42328831.0RepeatNote=WD 9
TgeneWDR75chr2:233028342chr2:190313105ENST00000314761021430_47428831.0RepeatNote=WD 10
TgeneWDR75chr2:233028342chr2:190313105ENST0000031476102147_8628831.0RepeatNote=WD 2
TgeneWDR75chr2:233028342chr2:190313105ENST00000314761021487_52528831.0RepeatNote=WD 11
TgeneWDR75chr2:233028342chr2:190313105ENST00000314761021529_56928831.0RepeatNote=WD 12
TgeneWDR75chr2:233028342chr2:190313105ENST00000314761021574_61128831.0RepeatNote=WD 13
TgeneWDR75chr2:233028342chr2:190313105ENST0000031476102190_13128831.0RepeatNote=WD 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWDR75chr2:233028342chr2:190313104ENST000003147610214_4328831.0RepeatNote=WD 1
TgeneWDR75chr2:233028342chr2:190313105ENST000003147610214_4328831.0RepeatNote=WD 1


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Fusion Gene Sequence for DIS3L2-WDR75


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22925_22925_1_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000273009_WDR75_chr2_190313104_ENST00000314761_length(transcript)=4293nt_BP=1738nt
ATGCGGGGGTTGTCCATCTCTGTATCCCCAGTGCCAGCACTGCACCTCGCCCCAAGCAGTTGTCCAATAAATGAGCAGTGAGTAAATGAA
AGAATGAGCAAAGCCTTGTAACAGGAAAGGGGCCGGCGGCGTCTGCCGTGCAAGACCTGGCCCAGTGGAGCAGAGCCTGGAGGTTCAGGA
GCCGGGTCTGGAAGGCTCCTTCCGGTGGAAGAGGGGCCCGGAGCCAGCCGGCGCCTGGCACAAGGCGTCTCAGAGGCCGCCCACTGGGAG
CCAACCGTTGCAGCCAGTTGTCCCCGCGAGCGAGGCCGGAGAAGGCGCGGCGGCCCCTGGCCTGGCCATTTCGCCCTTGTCGCAGCTGAA
CCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCACCGTCGCTCTCTAGAACGCCGCG
CCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAAACGCGAATGACAACAGAGCTGC
TCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAGCCAATAATGAGCCATCCTGACT
ACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCTTCGCCAGGTGACAAAA
AGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCAGAAGGCTTGAAGAGAG
GAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGTGATCGAGACATTTTTA
TTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCATTGGAAGGTAGTTAAAC
CAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTCCCGCAACAGTCCCTGA
AAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGCATCACACAAAATGTGC
TGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACAAAAGATGAGACCACCT
GCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAGAAAAAACATTCTCGAG
CAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCCTCAGACCACCGAGTGC
CTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTGTTCATCTGCCGCATTG
TGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAGCCTGAAACAGAAGGAA
TACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCATGGACAATTCCACCAG
AGGAGTTCAGCAAGAGAAGGGATTTAAGGTATATCTTCTGTGTCTCTGGAGACTTTGTTAAAGTTTACAGCACAGTTACAGAAGAGTGTG
TACACATACTGCATGGACACAGAAATCTGGTGACTGGAATCCAGCTTAACCCCAACAACCATCTACAGCTGTATTCTTGTTCCCTTGATG
GCACAATTAAACTGTGGGACTATATAGATGGCATCTTAATAAAGACTTTCATAGTTGGATGTAAACTTCATGCCCTCTTTACTCTTGCCC
AAGCTGAGGATTCTGTCTTTGTTATAGTGAATAAAGAAAAACCAGATATATTTCAGCTGGTTTCAGTGAAACTGCCAAAATCCTCAAGCC
AGGAAGTAGAAGCCAAGGAGCTGTCCTTTGTTTTGGATTACATAAACCAGTCACCCAAGTGCATTGCCTTTGGAAACGAGGGAGTATATG
TTGCTGCAGTACGGGAATTTTACTTGTCTGTTTATTTTTTCAAAAAGAAAACAACATCAAGGTTTACTTTATCATCATCAAGAAATAAGA
AGCATGCTAAAAACAATTTTACATGTGTAGCATGTCACCCAACGGAAGACTGCATCGCATCTGGTCACATGGATGGCAAAATTCGTCTTT
GGAGGAATTTTTATGATGATAAGAAATATACGTACACATGTTTACATTGGCACCATGATATGGTTATGGATTTGGCTTTTTCAGTGACAG
GCACCAGTCTGCTGAGTGGCGGTCGTGAATCTGTACTTGTAGAGTGGCGCGATGCAACAGAGAAGAATAAGGAGTTTCTCCCGCGTTTAG
GAGCTACTATTGAACATATCTCAGTCTCGCCTGCAGGAGATTTATTCTGCACTTCTCACTCTGATAATAAGATAATAATTATTCACCGAA
ACCTTGAAGCATCCGCAGTAATTCAAGGCCTAGTGAAAGATAGGAGTATCTTCACTGGTTTGATGATTGATCCAAGAACTAAAGCTTTGG
TTTTGAATGGAAAACCTGGCCACCTGCAGTTTTATTCTCTCCAGAGTGATAAACAGTTATACAATTTAGATATTATACAGCAAGAATATA
TTAATGATTATGGTCTGATCCAAATTGAACTAACAAAGGCTGCATTTGGCTGCTTTGGTAACTGGCTTGCAACAGTGGAACAGCGGCAAG
AAAAGGAAACTGAGCTTGAATTGCAAATGAAACTGTGGATGTATAATAAGAAAACACAAGGGTTTATTCTTAACACTAAAATTAACATGC
CACACGAAGACTGCATTACAGCTCTCTGTTTCTGTAATGCAGAAAAATCTGAACAGCCCACCTTGGTTACAGCTAGCAAAGATGGTTACT
TCAAAGTATGGATATTAACAGATGACTCTGACATATACAAAAAAGCTGTTGGCTGGACCTGTGACTTTGTTGGTAGTTATCACAAGTATC
AAGCAACTAACTGTTGTTTCTCCGAAGATGGTTCTTTACTAGCAGTTAGTTTTGAGGAAATAGTCACAATATGGGATTCTGTAACATGGG
AACTTAAATGTACATTTTGCCAACGAGCTGGGAAAATAAGGCACCTTTGCTTTGGGAGATTGACGTGTTCAAAGTATCTACTTGGTGCTA
CTGAAAATGGCATTCTTTGCTGTTGGAATCTGCTGAGCTGTGCATTGGAGTGGAATGCAAAATTAAATGTTAGAGTTATGGAACCCGATC
CTAATTCAGAGAATATTGCTGCAATCTCTCAGTCTTCAGTGGGTTCAGACTTGTTTGTATTTAAACCTAGTGAGCCAAGGCCATTGTATA
TTCAAAAGGGTATCTCCAGAGAGAAAGTCCAGTGGGGAGTGTTTGTTCCACGAGATGTCCCTGAATCCTTCACCTCAGAAGCTTACCAGT
GGCTAAATAGATCCCAGTTTTACTTCCTAACAAAATCACAGAGTTTATTGACATTCAGTACAAAGTCTCCAGAAGAAAAACTCACACCAA
CAAGCAAACAGCTGCTAGCAGAAGAAAGTCTTCCCACAACCCCATTTTATTTCATATTGGGAAAACACAGGCAACAGCAGGATGAAAAAC
TAAACGAAACTTTAGAGAATGAGCTGGTACAACTACCCTTAACAGAAAACATACCCGCAATTAGTGAGCTTCTTCACACTCCAGCCCATG
TCCTGCCATCTGCTGCTTTCCTGTGCTCCATGTTTGTAAATTCATTGCTGCTGTCTAAAGAGACTAAGAGTGCTAAGGAAATTCCTGAAG
ATGTAGATATGGAAGAAGAAAAAGAAAGTGAAGATTCAGATGAAGAAAATGATTTTACCGAAAAAGTCCAGGATACAAGTAACACAGGTT
TAGGAGAAGACATTATACATCAGTTGTCAAAATCTGAAGAAAAAGAACTGAGAAAATTTAGGAAAATAGACTACAGCTGGATAGCTGCCC
TTTAAGCCTTGGAGATGGGGAGGATCCTTGGACTTTGTGTTTTTGATTGTATGTTGATATTCTAAAAACATCTATTTTAATGTTATTTCT

>22925_22925_1_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000273009_WDR75_chr2_190313104_ENST00000314761_length(amino acids)=1188AA_BP=386
MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK
KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA
QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN
SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS
SEVLECLPQGLPWTIPPEEFSKRRDLRYIFCVSGDFVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGIL
IKTFIVGCKLHALFTLAQAEDSVFVIVNKEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSVYF
FKKKTTSRFTLSSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMDLAFSVTGTSLLSGGRESVL
VEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDNKIIIIHRNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYS
LQSDKQLYNLDIIQQEYINDYGLIQIELTKAAFGCFGNWLATVEQRQEKETELELQMKLWMYNKKTQGFILNTKINMPHEDCITALCFCN
AEKSEQPTLVTASKDGYFKVWILTDDSDIYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLLAVSFEEIVTIWDSVTWELKCTFCQRAGKI
RHLCFGRLTCSKYLLGATENGILCCWNLLSCALEWNAKLNVRVMEPDPNSENIAAISQSSVGSDLFVFKPSEPRPLYIQKGISREKVQWG
VFVPRDVPESFTSEAYQWLNRSQFYFLTKSQSLLTFSTKSPEEKLTPTSKQLLAEESLPTTPFYFILGKHRQQQDEKLNETLENELVQLP
LTENIPAISELLHTPAHVLPSAAFLCSMFVNSLLLSKETKSAKEIPEDVDMEEEKESEDSDEENDFTEKVQDTSNTGLGEDIIHQLSKSE

--------------------------------------------------------------
>22925_22925_2_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000273009_WDR75_chr2_190313105_ENST00000314761_length(transcript)=4293nt_BP=1738nt
ATGCGGGGGTTGTCCATCTCTGTATCCCCAGTGCCAGCACTGCACCTCGCCCCAAGCAGTTGTCCAATAAATGAGCAGTGAGTAAATGAA
AGAATGAGCAAAGCCTTGTAACAGGAAAGGGGCCGGCGGCGTCTGCCGTGCAAGACCTGGCCCAGTGGAGCAGAGCCTGGAGGTTCAGGA
GCCGGGTCTGGAAGGCTCCTTCCGGTGGAAGAGGGGCCCGGAGCCAGCCGGCGCCTGGCACAAGGCGTCTCAGAGGCCGCCCACTGGGAG
CCAACCGTTGCAGCCAGTTGTCCCCGCGAGCGAGGCCGGAGAAGGCGCGGCGGCCCCTGGCCTGGCCATTTCGCCCTTGTCGCAGCTGAA
CCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCACCGTCGCTCTCTAGAACGCCGCG
CCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAAACGCGAATGACAACAGAGCTGC
TCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAGCCAATAATGAGCCATCCTGACT
ACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCTTCGCCAGGTGACAAAA
AGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCAGAAGGCTTGAAGAGAG
GAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGTGATCGAGACATTTTTA
TTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCATTGGAAGGTAGTTAAAC
CAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTCCCGCAACAGTCCCTGA
AAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGCATCACACAAAATGTGC
TGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACAAAAGATGAGACCACCT
GCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAGAAAAAACATTCTCGAG
CAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCCTCAGACCACCGAGTGC
CTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTGTTCATCTGCCGCATTG
TGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAGCCTGAAACAGAAGGAA
TACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCATGGACAATTCCACCAG
AGGAGTTCAGCAAGAGAAGGGATTTAAGGTATATCTTCTGTGTCTCTGGAGACTTTGTTAAAGTTTACAGCACAGTTACAGAAGAGTGTG
TACACATACTGCATGGACACAGAAATCTGGTGACTGGAATCCAGCTTAACCCCAACAACCATCTACAGCTGTATTCTTGTTCCCTTGATG
GCACAATTAAACTGTGGGACTATATAGATGGCATCTTAATAAAGACTTTCATAGTTGGATGTAAACTTCATGCCCTCTTTACTCTTGCCC
AAGCTGAGGATTCTGTCTTTGTTATAGTGAATAAAGAAAAACCAGATATATTTCAGCTGGTTTCAGTGAAACTGCCAAAATCCTCAAGCC
AGGAAGTAGAAGCCAAGGAGCTGTCCTTTGTTTTGGATTACATAAACCAGTCACCCAAGTGCATTGCCTTTGGAAACGAGGGAGTATATG
TTGCTGCAGTACGGGAATTTTACTTGTCTGTTTATTTTTTCAAAAAGAAAACAACATCAAGGTTTACTTTATCATCATCAAGAAATAAGA
AGCATGCTAAAAACAATTTTACATGTGTAGCATGTCACCCAACGGAAGACTGCATCGCATCTGGTCACATGGATGGCAAAATTCGTCTTT
GGAGGAATTTTTATGATGATAAGAAATATACGTACACATGTTTACATTGGCACCATGATATGGTTATGGATTTGGCTTTTTCAGTGACAG
GCACCAGTCTGCTGAGTGGCGGTCGTGAATCTGTACTTGTAGAGTGGCGCGATGCAACAGAGAAGAATAAGGAGTTTCTCCCGCGTTTAG
GAGCTACTATTGAACATATCTCAGTCTCGCCTGCAGGAGATTTATTCTGCACTTCTCACTCTGATAATAAGATAATAATTATTCACCGAA
ACCTTGAAGCATCCGCAGTAATTCAAGGCCTAGTGAAAGATAGGAGTATCTTCACTGGTTTGATGATTGATCCAAGAACTAAAGCTTTGG
TTTTGAATGGAAAACCTGGCCACCTGCAGTTTTATTCTCTCCAGAGTGATAAACAGTTATACAATTTAGATATTATACAGCAAGAATATA
TTAATGATTATGGTCTGATCCAAATTGAACTAACAAAGGCTGCATTTGGCTGCTTTGGTAACTGGCTTGCAACAGTGGAACAGCGGCAAG
AAAAGGAAACTGAGCTTGAATTGCAAATGAAACTGTGGATGTATAATAAGAAAACACAAGGGTTTATTCTTAACACTAAAATTAACATGC
CACACGAAGACTGCATTACAGCTCTCTGTTTCTGTAATGCAGAAAAATCTGAACAGCCCACCTTGGTTACAGCTAGCAAAGATGGTTACT
TCAAAGTATGGATATTAACAGATGACTCTGACATATACAAAAAAGCTGTTGGCTGGACCTGTGACTTTGTTGGTAGTTATCACAAGTATC
AAGCAACTAACTGTTGTTTCTCCGAAGATGGTTCTTTACTAGCAGTTAGTTTTGAGGAAATAGTCACAATATGGGATTCTGTAACATGGG
AACTTAAATGTACATTTTGCCAACGAGCTGGGAAAATAAGGCACCTTTGCTTTGGGAGATTGACGTGTTCAAAGTATCTACTTGGTGCTA
CTGAAAATGGCATTCTTTGCTGTTGGAATCTGCTGAGCTGTGCATTGGAGTGGAATGCAAAATTAAATGTTAGAGTTATGGAACCCGATC
CTAATTCAGAGAATATTGCTGCAATCTCTCAGTCTTCAGTGGGTTCAGACTTGTTTGTATTTAAACCTAGTGAGCCAAGGCCATTGTATA
TTCAAAAGGGTATCTCCAGAGAGAAAGTCCAGTGGGGAGTGTTTGTTCCACGAGATGTCCCTGAATCCTTCACCTCAGAAGCTTACCAGT
GGCTAAATAGATCCCAGTTTTACTTCCTAACAAAATCACAGAGTTTATTGACATTCAGTACAAAGTCTCCAGAAGAAAAACTCACACCAA
CAAGCAAACAGCTGCTAGCAGAAGAAAGTCTTCCCACAACCCCATTTTATTTCATATTGGGAAAACACAGGCAACAGCAGGATGAAAAAC
TAAACGAAACTTTAGAGAATGAGCTGGTACAACTACCCTTAACAGAAAACATACCCGCAATTAGTGAGCTTCTTCACACTCCAGCCCATG
TCCTGCCATCTGCTGCTTTCCTGTGCTCCATGTTTGTAAATTCATTGCTGCTGTCTAAAGAGACTAAGAGTGCTAAGGAAATTCCTGAAG
ATGTAGATATGGAAGAAGAAAAAGAAAGTGAAGATTCAGATGAAGAAAATGATTTTACCGAAAAAGTCCAGGATACAAGTAACACAGGTT
TAGGAGAAGACATTATACATCAGTTGTCAAAATCTGAAGAAAAAGAACTGAGAAAATTTAGGAAAATAGACTACAGCTGGATAGCTGCCC
TTTAAGCCTTGGAGATGGGGAGGATCCTTGGACTTTGTGTTTTTGATTGTATGTTGATATTCTAAAAACATCTATTTTAATGTTATTTCT

>22925_22925_2_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000273009_WDR75_chr2_190313105_ENST00000314761_length(amino acids)=1188AA_BP=386
MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK
KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA
QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN
SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS
SEVLECLPQGLPWTIPPEEFSKRRDLRYIFCVSGDFVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGIL
IKTFIVGCKLHALFTLAQAEDSVFVIVNKEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSVYF
FKKKTTSRFTLSSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMDLAFSVTGTSLLSGGRESVL
VEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDNKIIIIHRNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYS
LQSDKQLYNLDIIQQEYINDYGLIQIELTKAAFGCFGNWLATVEQRQEKETELELQMKLWMYNKKTQGFILNTKINMPHEDCITALCFCN
AEKSEQPTLVTASKDGYFKVWILTDDSDIYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLLAVSFEEIVTIWDSVTWELKCTFCQRAGKI
RHLCFGRLTCSKYLLGATENGILCCWNLLSCALEWNAKLNVRVMEPDPNSENIAAISQSSVGSDLFVFKPSEPRPLYIQKGISREKVQWG
VFVPRDVPESFTSEAYQWLNRSQFYFLTKSQSLLTFSTKSPEEKLTPTSKQLLAEESLPTTPFYFILGKHRQQQDEKLNETLENELVQLP
LTENIPAISELLHTPAHVLPSAAFLCSMFVNSLLLSKETKSAKEIPEDVDMEEEKESEDSDEENDFTEKVQDTSNTGLGEDIIHQLSKSE

--------------------------------------------------------------
>22925_22925_3_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000325385_WDR75_chr2_190313104_ENST00000314761_length(transcript)=3955nt_BP=1400nt
TTTCGCCCTTGTCGCAGCTGAACCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCAC
CGTCGCTCTCTAGAACGCCGCGCCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAA
ACGCGAATGACAACAGAGCTGCTCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAG
CCAATAATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATT
GGTGCTTCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGAT
GTTTCAGAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCG
GATGGTGATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAG
GAGCATTGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACAC
CATCTCCCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGA
CATGGCATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCG
GTTACAAAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATC
TTGGAGAAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTT
TCTCCCTCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAAC
ACACTGTTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAA
ATTGAGCCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGC
CTGCCATGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGGTATATCTTCTGTGTCTCTGGAGACTTTGTTAAAGTTTAC
AGCACAGTTACAGAAGAGTGTGTACACATACTGCATGGACACAGAAATCTGGTGACTGGAATCCAGCTTAACCCCAACAACCATCTACAG
CTGTATTCTTGTTCCCTTGATGGCACAATTAAACTGTGGGACTATATAGATGGCATCTTAATAAAGACTTTCATAGTTGGATGTAAACTT
CATGCCCTCTTTACTCTTGCCCAAGCTGAGGATTCTGTCTTTGTTATAGTGAATAAAGAAAAACCAGATATATTTCAGCTGGTTTCAGTG
AAACTGCCAAAATCCTCAAGCCAGGAAGTAGAAGCCAAGGAGCTGTCCTTTGTTTTGGATTACATAAACCAGTCACCCAAGTGCATTGCC
TTTGGAAACGAGGGAGTATATGTTGCTGCAGTACGGGAATTTTACTTGTCTGTTTATTTTTTCAAAAAGAAAACAACATCAAGGTTTACT
TTATCATCATCAAGAAATAAGAAGCATGCTAAAAACAATTTTACATGTGTAGCATGTCACCCAACGGAAGACTGCATCGCATCTGGTCAC
ATGGATGGCAAAATTCGTCTTTGGAGGAATTTTTATGATGATAAGAAATATACGTACACATGTTTACATTGGCACCATGATATGGTTATG
GATTTGGCTTTTTCAGTGACAGGCACCAGTCTGCTGAGTGGCGGTCGTGAATCTGTACTTGTAGAGTGGCGCGATGCAACAGAGAAGAAT
AAGGAGTTTCTCCCGCGTTTAGGAGCTACTATTGAACATATCTCAGTCTCGCCTGCAGGAGATTTATTCTGCACTTCTCACTCTGATAAT
AAGATAATAATTATTCACCGAAACCTTGAAGCATCCGCAGTAATTCAAGGCCTAGTGAAAGATAGGAGTATCTTCACTGGTTTGATGATT
GATCCAAGAACTAAAGCTTTGGTTTTGAATGGAAAACCTGGCCACCTGCAGTTTTATTCTCTCCAGAGTGATAAACAGTTATACAATTTA
GATATTATACAGCAAGAATATATTAATGATTATGGTCTGATCCAAATTGAACTAACAAAGGCTGCATTTGGCTGCTTTGGTAACTGGCTT
GCAACAGTGGAACAGCGGCAAGAAAAGGAAACTGAGCTTGAATTGCAAATGAAACTGTGGATGTATAATAAGAAAACACAAGGGTTTATT
CTTAACACTAAAATTAACATGCCACACGAAGACTGCATTACAGCTCTCTGTTTCTGTAATGCAGAAAAATCTGAACAGCCCACCTTGGTT
ACAGCTAGCAAAGATGGTTACTTCAAAGTATGGATATTAACAGATGACTCTGACATATACAAAAAAGCTGTTGGCTGGACCTGTGACTTT
GTTGGTAGTTATCACAAGTATCAAGCAACTAACTGTTGTTTCTCCGAAGATGGTTCTTTACTAGCAGTTAGTTTTGAGGAAATAGTCACA
ATATGGGATTCTGTAACATGGGAACTTAAATGTACATTTTGCCAACGAGCTGGGAAAATAAGGCACCTTTGCTTTGGGAGATTGACGTGT
TCAAAGTATCTACTTGGTGCTACTGAAAATGGCATTCTTTGCTGTTGGAATCTGCTGAGCTGTGCATTGGAGTGGAATGCAAAATTAAAT
GTTAGAGTTATGGAACCCGATCCTAATTCAGAGAATATTGCTGCAATCTCTCAGTCTTCAGTGGGTTCAGACTTGTTTGTATTTAAACCT
AGTGAGCCAAGGCCATTGTATATTCAAAAGGGTATCTCCAGAGAGAAAGTCCAGTGGGGAGTGTTTGTTCCACGAGATGTCCCTGAATCC
TTCACCTCAGAAGCTTACCAGTGGCTAAATAGATCCCAGTTTTACTTCCTAACAAAATCACAGAGTTTATTGACATTCAGTACAAAGTCT
CCAGAAGAAAAACTCACACCAACAAGCAAACAGCTGCTAGCAGAAGAAAGTCTTCCCACAACCCCATTTTATTTCATATTGGGAAAACAC
AGGCAACAGCAGGATGAAAAACTAAACGAAACTTTAGAGAATGAGCTGGTACAACTACCCTTAACAGAAAACATACCCGCAATTAGTGAG
CTTCTTCACACTCCAGCCCATGTCCTGCCATCTGCTGCTTTCCTGTGCTCCATGTTTGTAAATTCATTGCTGCTGTCTAAAGAGACTAAG
AGTGCTAAGGAAATTCCTGAAGATGTAGATATGGAAGAAGAAAAAGAAAGTGAAGATTCAGATGAAGAAAATGATTTTACCGAAAAAGTC
CAGGATACAAGTAACACAGGTTTAGGAGAAGACATTATACATCAGTTGTCAAAATCTGAAGAAAAAGAACTGAGAAAATTTAGGAAAATA
GACTACAGCTGGATAGCTGCCCTTTAAGCCTTGGAGATGGGGAGGATCCTTGGACTTTGTGTTTTTGATTGTATGTTGATATTCTAAAAA

>22925_22925_3_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000325385_WDR75_chr2_190313104_ENST00000314761_length(amino acids)=1188AA_BP=386
MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK
KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA
QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN
SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS
SEVLECLPQGLPWTIPPEEFSKRRDLRYIFCVSGDFVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGIL
IKTFIVGCKLHALFTLAQAEDSVFVIVNKEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSVYF
FKKKTTSRFTLSSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMDLAFSVTGTSLLSGGRESVL
VEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDNKIIIIHRNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYS
LQSDKQLYNLDIIQQEYINDYGLIQIELTKAAFGCFGNWLATVEQRQEKETELELQMKLWMYNKKTQGFILNTKINMPHEDCITALCFCN
AEKSEQPTLVTASKDGYFKVWILTDDSDIYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLLAVSFEEIVTIWDSVTWELKCTFCQRAGKI
RHLCFGRLTCSKYLLGATENGILCCWNLLSCALEWNAKLNVRVMEPDPNSENIAAISQSSVGSDLFVFKPSEPRPLYIQKGISREKVQWG
VFVPRDVPESFTSEAYQWLNRSQFYFLTKSQSLLTFSTKSPEEKLTPTSKQLLAEESLPTTPFYFILGKHRQQQDEKLNETLENELVQLP
LTENIPAISELLHTPAHVLPSAAFLCSMFVNSLLLSKETKSAKEIPEDVDMEEEKESEDSDEENDFTEKVQDTSNTGLGEDIIHQLSKSE

--------------------------------------------------------------
>22925_22925_4_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000325385_WDR75_chr2_190313105_ENST00000314761_length(transcript)=3955nt_BP=1400nt
TTTCGCCCTTGTCGCAGCTGAACCGCCGACTACGAGCTCCTGCACCGCGCACACACCCCGCGCGCTTCGCTCTCGGCCTCGCCCGGCCAC
CGTCGCTCTCTAGAACGCCGCGCCCGTGACCCGGAAGAGCATTCTCCTTAGCAACTGCGGGACTGCGGCGGCGCCGGCCTCCGGGGAGAA
ACGCGAATGACAACAGAGCTGCTCAAGGCGGGAACTCTGAGCTAAGCAGTGGAGGTTTCTCTGGATCTGGAGAGAAGAGTGACCTTGGAG
CCAATAATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATT
GGTGCTTCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGAT
GTTTCAGAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCG
GATGGTGATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAG
GAGCATTGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACAC
CATCTCCCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGA
CATGGCATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCG
GTTACAAAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATC
TTGGAGAAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTT
TCTCCCTCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAAC
ACACTGTTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAA
ATTGAGCCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGC
CTGCCATGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGGTATATCTTCTGTGTCTCTGGAGACTTTGTTAAAGTTTAC
AGCACAGTTACAGAAGAGTGTGTACACATACTGCATGGACACAGAAATCTGGTGACTGGAATCCAGCTTAACCCCAACAACCATCTACAG
CTGTATTCTTGTTCCCTTGATGGCACAATTAAACTGTGGGACTATATAGATGGCATCTTAATAAAGACTTTCATAGTTGGATGTAAACTT
CATGCCCTCTTTACTCTTGCCCAAGCTGAGGATTCTGTCTTTGTTATAGTGAATAAAGAAAAACCAGATATATTTCAGCTGGTTTCAGTG
AAACTGCCAAAATCCTCAAGCCAGGAAGTAGAAGCCAAGGAGCTGTCCTTTGTTTTGGATTACATAAACCAGTCACCCAAGTGCATTGCC
TTTGGAAACGAGGGAGTATATGTTGCTGCAGTACGGGAATTTTACTTGTCTGTTTATTTTTTCAAAAAGAAAACAACATCAAGGTTTACT
TTATCATCATCAAGAAATAAGAAGCATGCTAAAAACAATTTTACATGTGTAGCATGTCACCCAACGGAAGACTGCATCGCATCTGGTCAC
ATGGATGGCAAAATTCGTCTTTGGAGGAATTTTTATGATGATAAGAAATATACGTACACATGTTTACATTGGCACCATGATATGGTTATG
GATTTGGCTTTTTCAGTGACAGGCACCAGTCTGCTGAGTGGCGGTCGTGAATCTGTACTTGTAGAGTGGCGCGATGCAACAGAGAAGAAT
AAGGAGTTTCTCCCGCGTTTAGGAGCTACTATTGAACATATCTCAGTCTCGCCTGCAGGAGATTTATTCTGCACTTCTCACTCTGATAAT
AAGATAATAATTATTCACCGAAACCTTGAAGCATCCGCAGTAATTCAAGGCCTAGTGAAAGATAGGAGTATCTTCACTGGTTTGATGATT
GATCCAAGAACTAAAGCTTTGGTTTTGAATGGAAAACCTGGCCACCTGCAGTTTTATTCTCTCCAGAGTGATAAACAGTTATACAATTTA
GATATTATACAGCAAGAATATATTAATGATTATGGTCTGATCCAAATTGAACTAACAAAGGCTGCATTTGGCTGCTTTGGTAACTGGCTT
GCAACAGTGGAACAGCGGCAAGAAAAGGAAACTGAGCTTGAATTGCAAATGAAACTGTGGATGTATAATAAGAAAACACAAGGGTTTATT
CTTAACACTAAAATTAACATGCCACACGAAGACTGCATTACAGCTCTCTGTTTCTGTAATGCAGAAAAATCTGAACAGCCCACCTTGGTT
ACAGCTAGCAAAGATGGTTACTTCAAAGTATGGATATTAACAGATGACTCTGACATATACAAAAAAGCTGTTGGCTGGACCTGTGACTTT
GTTGGTAGTTATCACAAGTATCAAGCAACTAACTGTTGTTTCTCCGAAGATGGTTCTTTACTAGCAGTTAGTTTTGAGGAAATAGTCACA
ATATGGGATTCTGTAACATGGGAACTTAAATGTACATTTTGCCAACGAGCTGGGAAAATAAGGCACCTTTGCTTTGGGAGATTGACGTGT
TCAAAGTATCTACTTGGTGCTACTGAAAATGGCATTCTTTGCTGTTGGAATCTGCTGAGCTGTGCATTGGAGTGGAATGCAAAATTAAAT
GTTAGAGTTATGGAACCCGATCCTAATTCAGAGAATATTGCTGCAATCTCTCAGTCTTCAGTGGGTTCAGACTTGTTTGTATTTAAACCT
AGTGAGCCAAGGCCATTGTATATTCAAAAGGGTATCTCCAGAGAGAAAGTCCAGTGGGGAGTGTTTGTTCCACGAGATGTCCCTGAATCC
TTCACCTCAGAAGCTTACCAGTGGCTAAATAGATCCCAGTTTTACTTCCTAACAAAATCACAGAGTTTATTGACATTCAGTACAAAGTCT
CCAGAAGAAAAACTCACACCAACAAGCAAACAGCTGCTAGCAGAAGAAAGTCTTCCCACAACCCCATTTTATTTCATATTGGGAAAACAC
AGGCAACAGCAGGATGAAAAACTAAACGAAACTTTAGAGAATGAGCTGGTACAACTACCCTTAACAGAAAACATACCCGCAATTAGTGAG
CTTCTTCACACTCCAGCCCATGTCCTGCCATCTGCTGCTTTCCTGTGCTCCATGTTTGTAAATTCATTGCTGCTGTCTAAAGAGACTAAG
AGTGCTAAGGAAATTCCTGAAGATGTAGATATGGAAGAAGAAAAAGAAAGTGAAGATTCAGATGAAGAAAATGATTTTACCGAAAAAGTC
CAGGATACAAGTAACACAGGTTTAGGAGAAGACATTATACATCAGTTGTCAAAATCTGAAGAAAAAGAACTGAGAAAATTTAGGAAAATA
GACTACAGCTGGATAGCTGCCCTTTAAGCCTTGGAGATGGGGAGGATCCTTGGACTTTGTGTTTTTGATTGTATGTTGATATTCTAAAAA

>22925_22925_4_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000325385_WDR75_chr2_190313105_ENST00000314761_length(amino acids)=1188AA_BP=386
MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK
KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA
QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN
SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS
SEVLECLPQGLPWTIPPEEFSKRRDLRYIFCVSGDFVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGIL
IKTFIVGCKLHALFTLAQAEDSVFVIVNKEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSVYF
FKKKTTSRFTLSSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMDLAFSVTGTSLLSGGRESVL
VEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDNKIIIIHRNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYS
LQSDKQLYNLDIIQQEYINDYGLIQIELTKAAFGCFGNWLATVEQRQEKETELELQMKLWMYNKKTQGFILNTKINMPHEDCITALCFCN
AEKSEQPTLVTASKDGYFKVWILTDDSDIYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLLAVSFEEIVTIWDSVTWELKCTFCQRAGKI
RHLCFGRLTCSKYLLGATENGILCCWNLLSCALEWNAKLNVRVMEPDPNSENIAAISQSSVGSDLFVFKPSEPRPLYIQKGISREKVQWG
VFVPRDVPESFTSEAYQWLNRSQFYFLTKSQSLLTFSTKSPEEKLTPTSKQLLAEESLPTTPFYFILGKHRQQQDEKLNETLENELVQLP
LTENIPAISELLHTPAHVLPSAAFLCSMFVNSLLLSKETKSAKEIPEDVDMEEEKESEDSDEENDFTEKVQDTSNTGLGEDIIHQLSKSE

--------------------------------------------------------------
>22925_22925_5_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000409307_WDR75_chr2_190313104_ENST00000314761_length(transcript)=3679nt_BP=1124nt
ATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCT
TCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCA
GAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGT
GATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCAT
TGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTC
CCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGC
ATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACA
AAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAG
AAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCC
TCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTG
TTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAG
CCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCA
TGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGGTATATCTTCTGTGTCTCTGGAGACTTTGTTAAAGTTTACAGCACA
GTTACAGAAGAGTGTGTACACATACTGCATGGACACAGAAATCTGGTGACTGGAATCCAGCTTAACCCCAACAACCATCTACAGCTGTAT
TCTTGTTCCCTTGATGGCACAATTAAACTGTGGGACTATATAGATGGCATCTTAATAAAGACTTTCATAGTTGGATGTAAACTTCATGCC
CTCTTTACTCTTGCCCAAGCTGAGGATTCTGTCTTTGTTATAGTGAATAAAGAAAAACCAGATATATTTCAGCTGGTTTCAGTGAAACTG
CCAAAATCCTCAAGCCAGGAAGTAGAAGCCAAGGAGCTGTCCTTTGTTTTGGATTACATAAACCAGTCACCCAAGTGCATTGCCTTTGGA
AACGAGGGAGTATATGTTGCTGCAGTACGGGAATTTTACTTGTCTGTTTATTTTTTCAAAAAGAAAACAACATCAAGGTTTACTTTATCA
TCATCAAGAAATAAGAAGCATGCTAAAAACAATTTTACATGTGTAGCATGTCACCCAACGGAAGACTGCATCGCATCTGGTCACATGGAT
GGCAAAATTCGTCTTTGGAGGAATTTTTATGATGATAAGAAATATACGTACACATGTTTACATTGGCACCATGATATGGTTATGGATTTG
GCTTTTTCAGTGACAGGCACCAGTCTGCTGAGTGGCGGTCGTGAATCTGTACTTGTAGAGTGGCGCGATGCAACAGAGAAGAATAAGGAG
TTTCTCCCGCGTTTAGGAGCTACTATTGAACATATCTCAGTCTCGCCTGCAGGAGATTTATTCTGCACTTCTCACTCTGATAATAAGATA
ATAATTATTCACCGAAACCTTGAAGCATCCGCAGTAATTCAAGGCCTAGTGAAAGATAGGAGTATCTTCACTGGTTTGATGATTGATCCA
AGAACTAAAGCTTTGGTTTTGAATGGAAAACCTGGCCACCTGCAGTTTTATTCTCTCCAGAGTGATAAACAGTTATACAATTTAGATATT
ATACAGCAAGAATATATTAATGATTATGGTCTGATCCAAATTGAACTAACAAAGGCTGCATTTGGCTGCTTTGGTAACTGGCTTGCAACA
GTGGAACAGCGGCAAGAAAAGGAAACTGAGCTTGAATTGCAAATGAAACTGTGGATGTATAATAAGAAAACACAAGGGTTTATTCTTAAC
ACTAAAATTAACATGCCACACGAAGACTGCATTACAGCTCTCTGTTTCTGTAATGCAGAAAAATCTGAACAGCCCACCTTGGTTACAGCT
AGCAAAGATGGTTACTTCAAAGTATGGATATTAACAGATGACTCTGACATATACAAAAAAGCTGTTGGCTGGACCTGTGACTTTGTTGGT
AGTTATCACAAGTATCAAGCAACTAACTGTTGTTTCTCCGAAGATGGTTCTTTACTAGCAGTTAGTTTTGAGGAAATAGTCACAATATGG
GATTCTGTAACATGGGAACTTAAATGTACATTTTGCCAACGAGCTGGGAAAATAAGGCACCTTTGCTTTGGGAGATTGACGTGTTCAAAG
TATCTACTTGGTGCTACTGAAAATGGCATTCTTTGCTGTTGGAATCTGCTGAGCTGTGCATTGGAGTGGAATGCAAAATTAAATGTTAGA
GTTATGGAACCCGATCCTAATTCAGAGAATATTGCTGCAATCTCTCAGTCTTCAGTGGGTTCAGACTTGTTTGTATTTAAACCTAGTGAG
CCAAGGCCATTGTATATTCAAAAGGGTATCTCCAGAGAGAAAGTCCAGTGGGGAGTGTTTGTTCCACGAGATGTCCCTGAATCCTTCACC
TCAGAAGCTTACCAGTGGCTAAATAGATCCCAGTTTTACTTCCTAACAAAATCACAGAGTTTATTGACATTCAGTACAAAGTCTCCAGAA
GAAAAACTCACACCAACAAGCAAACAGCTGCTAGCAGAAGAAAGTCTTCCCACAACCCCATTTTATTTCATATTGGGAAAACACAGGCAA
CAGCAGGATGAAAAACTAAACGAAACTTTAGAGAATGAGCTGGTACAACTACCCTTAACAGAAAACATACCCGCAATTAGTGAGCTTCTT
CACACTCCAGCCCATGTCCTGCCATCTGCTGCTTTCCTGTGCTCCATGTTTGTAAATTCATTGCTGCTGTCTAAAGAGACTAAGAGTGCT
AAGGAAATTCCTGAAGATGTAGATATGGAAGAAGAAAAAGAAAGTGAAGATTCAGATGAAGAAAATGATTTTACCGAAAAAGTCCAGGAT
ACAAGTAACACAGGTTTAGGAGAAGACATTATACATCAGTTGTCAAAATCTGAAGAAAAAGAACTGAGAAAATTTAGGAAAATAGACTAC
AGCTGGATAGCTGCCCTTTAAGCCTTGGAGATGGGGAGGATCCTTGGACTTTGTGTTTTTGATTGTATGTTGATATTCTAAAAACATCTA

>22925_22925_5_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000409307_WDR75_chr2_190313104_ENST00000314761_length(amino acids)=1176AA_BP=374
MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG
DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG
ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP
SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP
WTIPPEEFSKRRDLRYIFCVSGDFVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGILIKTFIVGCKLHA
LFTLAQAEDSVFVIVNKEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSVYFFKKKTTSRFTLS
SSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKE
FLPRLGATIEHISVSPAGDLFCTSHSDNKIIIIHRNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYSLQSDKQLYNLDI
IQQEYINDYGLIQIELTKAAFGCFGNWLATVEQRQEKETELELQMKLWMYNKKTQGFILNTKINMPHEDCITALCFCNAEKSEQPTLVTA
SKDGYFKVWILTDDSDIYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLLAVSFEEIVTIWDSVTWELKCTFCQRAGKIRHLCFGRLTCSK
YLLGATENGILCCWNLLSCALEWNAKLNVRVMEPDPNSENIAAISQSSVGSDLFVFKPSEPRPLYIQKGISREKVQWGVFVPRDVPESFT
SEAYQWLNRSQFYFLTKSQSLLTFSTKSPEEKLTPTSKQLLAEESLPTTPFYFILGKHRQQQDEKLNETLENELVQLPLTENIPAISELL
HTPAHVLPSAAFLCSMFVNSLLLSKETKSAKEIPEDVDMEEEKESEDSDEENDFTEKVQDTSNTGLGEDIIHQLSKSEEKELRKFRKIDY

--------------------------------------------------------------
>22925_22925_6_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000409307_WDR75_chr2_190313105_ENST00000314761_length(transcript)=3679nt_BP=1124nt
ATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAGGTGTGTCTGCTGTGGCTGGTCCACATGACATTGGTGCT
TCGCCAGGTGACAAAAAGTCAAAGAACAGGTCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCA
GAAGGCTTGAAGAGAGGAACACTCATCCAGGGTGTATTGAGAATTAATCCAAAGAAGTTTCATGAAGCCTTCATTCCTTCCCCGGATGGT
GATCGAGACATTTTTATTGATGGGGTTGTTGCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCAT
TGGAAGGTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGATATCCCCGAGGAGCTCTGTGGACACCATCTC
CCGCAACAGTCCCTGAAAAGCTATAATGACAGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGC
ATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAAGGAAGAGAGGATGGTGATGCACCGGTTACA
AAAGATGAGACCACCTGCATTTCACAAGACACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAGGTGGTTTACATCTTGGAG
AAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAACTGTTTAGGAAATACGCCCTGTTTTCTCCC
TCAGACCACCGAGTGCCTAGAATTTATGTGCCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTG
TTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGGGCAGCTGGCTAAGAGTCTTGGGCAGGCTGGTGAAATTGAG
CCTGAAACAGAAGGAATACTAACAGAGTATGGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCA
TGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAGGTATATCTTCTGTGTCTCTGGAGACTTTGTTAAAGTTTACAGCACA
GTTACAGAAGAGTGTGTACACATACTGCATGGACACAGAAATCTGGTGACTGGAATCCAGCTTAACCCCAACAACCATCTACAGCTGTAT
TCTTGTTCCCTTGATGGCACAATTAAACTGTGGGACTATATAGATGGCATCTTAATAAAGACTTTCATAGTTGGATGTAAACTTCATGCC
CTCTTTACTCTTGCCCAAGCTGAGGATTCTGTCTTTGTTATAGTGAATAAAGAAAAACCAGATATATTTCAGCTGGTTTCAGTGAAACTG
CCAAAATCCTCAAGCCAGGAAGTAGAAGCCAAGGAGCTGTCCTTTGTTTTGGATTACATAAACCAGTCACCCAAGTGCATTGCCTTTGGA
AACGAGGGAGTATATGTTGCTGCAGTACGGGAATTTTACTTGTCTGTTTATTTTTTCAAAAAGAAAACAACATCAAGGTTTACTTTATCA
TCATCAAGAAATAAGAAGCATGCTAAAAACAATTTTACATGTGTAGCATGTCACCCAACGGAAGACTGCATCGCATCTGGTCACATGGAT
GGCAAAATTCGTCTTTGGAGGAATTTTTATGATGATAAGAAATATACGTACACATGTTTACATTGGCACCATGATATGGTTATGGATTTG
GCTTTTTCAGTGACAGGCACCAGTCTGCTGAGTGGCGGTCGTGAATCTGTACTTGTAGAGTGGCGCGATGCAACAGAGAAGAATAAGGAG
TTTCTCCCGCGTTTAGGAGCTACTATTGAACATATCTCAGTCTCGCCTGCAGGAGATTTATTCTGCACTTCTCACTCTGATAATAAGATA
ATAATTATTCACCGAAACCTTGAAGCATCCGCAGTAATTCAAGGCCTAGTGAAAGATAGGAGTATCTTCACTGGTTTGATGATTGATCCA
AGAACTAAAGCTTTGGTTTTGAATGGAAAACCTGGCCACCTGCAGTTTTATTCTCTCCAGAGTGATAAACAGTTATACAATTTAGATATT
ATACAGCAAGAATATATTAATGATTATGGTCTGATCCAAATTGAACTAACAAAGGCTGCATTTGGCTGCTTTGGTAACTGGCTTGCAACA
GTGGAACAGCGGCAAGAAAAGGAAACTGAGCTTGAATTGCAAATGAAACTGTGGATGTATAATAAGAAAACACAAGGGTTTATTCTTAAC
ACTAAAATTAACATGCCACACGAAGACTGCATTACAGCTCTCTGTTTCTGTAATGCAGAAAAATCTGAACAGCCCACCTTGGTTACAGCT
AGCAAAGATGGTTACTTCAAAGTATGGATATTAACAGATGACTCTGACATATACAAAAAAGCTGTTGGCTGGACCTGTGACTTTGTTGGT
AGTTATCACAAGTATCAAGCAACTAACTGTTGTTTCTCCGAAGATGGTTCTTTACTAGCAGTTAGTTTTGAGGAAATAGTCACAATATGG
GATTCTGTAACATGGGAACTTAAATGTACATTTTGCCAACGAGCTGGGAAAATAAGGCACCTTTGCTTTGGGAGATTGACGTGTTCAAAG
TATCTACTTGGTGCTACTGAAAATGGCATTCTTTGCTGTTGGAATCTGCTGAGCTGTGCATTGGAGTGGAATGCAAAATTAAATGTTAGA
GTTATGGAACCCGATCCTAATTCAGAGAATATTGCTGCAATCTCTCAGTCTTCAGTGGGTTCAGACTTGTTTGTATTTAAACCTAGTGAG
CCAAGGCCATTGTATATTCAAAAGGGTATCTCCAGAGAGAAAGTCCAGTGGGGAGTGTTTGTTCCACGAGATGTCCCTGAATCCTTCACC
TCAGAAGCTTACCAGTGGCTAAATAGATCCCAGTTTTACTTCCTAACAAAATCACAGAGTTTATTGACATTCAGTACAAAGTCTCCAGAA
GAAAAACTCACACCAACAAGCAAACAGCTGCTAGCAGAAGAAAGTCTTCCCACAACCCCATTTTATTTCATATTGGGAAAACACAGGCAA
CAGCAGGATGAAAAACTAAACGAAACTTTAGAGAATGAGCTGGTACAACTACCCTTAACAGAAAACATACCCGCAATTAGTGAGCTTCTT
CACACTCCAGCCCATGTCCTGCCATCTGCTGCTTTCCTGTGCTCCATGTTTGTAAATTCATTGCTGCTGTCTAAAGAGACTAAGAGTGCT
AAGGAAATTCCTGAAGATGTAGATATGGAAGAAGAAAAAGAAAGTGAAGATTCAGATGAAGAAAATGATTTTACCGAAAAAGTCCAGGAT
ACAAGTAACACAGGTTTAGGAGAAGACATTATACATCAGTTGTCAAAATCTGAAGAAAAAGAACTGAGAAAATTTAGGAAAATAGACTAC
AGCTGGATAGCTGCCCTTTAAGCCTTGGAGATGGGGAGGATCCTTGGACTTTGTGTTTTTGATTGTATGTTGATATTCTAAAAACATCTA

>22925_22925_6_DIS3L2-WDR75_DIS3L2_chr2_233028342_ENST00000409307_WDR75_chr2_190313105_ENST00000314761_length(amino acids)=1176AA_BP=374
MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG
DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG
ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP
SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP
WTIPPEEFSKRRDLRYIFCVSGDFVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGILIKTFIVGCKLHA
LFTLAQAEDSVFVIVNKEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSVYFFKKKTTSRFTLS
SSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKE
FLPRLGATIEHISVSPAGDLFCTSHSDNKIIIIHRNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYSLQSDKQLYNLDI
IQQEYINDYGLIQIELTKAAFGCFGNWLATVEQRQEKETELELQMKLWMYNKKTQGFILNTKINMPHEDCITALCFCNAEKSEQPTLVTA
SKDGYFKVWILTDDSDIYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLLAVSFEEIVTIWDSVTWELKCTFCQRAGKIRHLCFGRLTCSK
YLLGATENGILCCWNLLSCALEWNAKLNVRVMEPDPNSENIAAISQSSVGSDLFVFKPSEPRPLYIQKGISREKVQWGVFVPRDVPESFT
SEAYQWLNRSQFYFLTKSQSLLTFSTKSPEEKLTPTSKQLLAEESLPTTPFYFILGKHRQQQDEKLNETLENELVQLPLTENIPAISELL
HTPAHVLPSAAFLCSMFVNSLLLSKETKSAKEIPEDVDMEEEKESEDSDEENDFTEKVQDTSNTGLGEDIIHQLSKSEEKELRKFRKIDY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DIS3L2-WDR75


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DIS3L2-WDR75


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DIS3L2-WDR75


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource