FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:DIXDC1-CTNND1 (FusionGDB2 ID:22951)

Fusion Gene Summary for DIXDC1-CTNND1

check button Fusion gene summary
Fusion gene informationFusion gene name: DIXDC1-CTNND1
Fusion gene ID: 22951
HgeneTgene
Gene symbol

DIXDC1

CTNND1

Gene ID

85458

100528016

Gene nameDIX domain containing 1TMX2-CTNND1 readthrough (NMD candidate)
SynonymsCCD1CAS|CTNND1|p120(cas)|p120(ctn)
Cytomap

11q23.1

11q12.1

Type of geneprotein-codingncRNA
Descriptiondixincoiled-coil protein DIX1Cadherin-associated Src substrateCatenin delta-1TMX2-CTNND1 readthrough (non-protein coding)p120 catenin
Modification date2020031320200313
UniProtAcc

Q155Q3

O60716

Ensembl transtripts involved in fusion geneENST00000389821, ENST00000440460, 
ENST00000531396, ENST00000315253, 
ENST00000529225, 		ENST00000358694, 
ENST00000360682, ENST00000361332, 
ENST00000361391, ENST00000361796, 
ENST00000399039, ENST00000399050, 
ENST00000415361, ENST00000426142, 
ENST00000428599, ENST00000524630, 
ENST00000525902, ENST00000526357, 
ENST00000526772, ENST00000526938, 
ENST00000527467, ENST00000528232, 
ENST00000528621, ENST00000529526, 
ENST00000529873, ENST00000529919, 
ENST00000529986, ENST00000530094, 
ENST00000530748, ENST00000531014, 
ENST00000532245, ENST00000532463, 
ENST00000532649, ENST00000532787, 
ENST00000532844, ENST00000533667, 
ENST00000534579, 
Fusion gene scores* DoF score7 X 6 X 4=16817 X 21 X 10=3570
# samples 925
** MAII scorelog2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/3570*10)=-3.83592407425437
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DIXDC1 [Title/Abstract] AND CTNND1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDIXDC1(111808191)-CTNND1(57561656), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDIXDC1

GO:0060070

canonical Wnt signaling pathway

21189423


check buttonFusion gene breakpoints across DIXDC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CTNND1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAX184673DIXDC1chr11

111808191

+CTNND1chr11

57561656

-


Top

Fusion Gene ORF analysis for DIXDC1-CTNND1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000389821ENST00000358694DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000360682DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000361332DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000361391DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000361796DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000399039DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000399050DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000415361DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000426142DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000428599DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000524630DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000525902DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000526357DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000526772DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000526938DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000527467DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000528232DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000528621DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000529526DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000529873DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000529919DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000529986DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000530094DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000530748DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000531014DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000532245DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000532463DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000532649DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000532787DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000532844DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000533667DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
3UTR-intronENST00000389821ENST00000534579DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000358694DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000360682DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000361332DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000361391DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000361796DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000399039DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000399050DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000415361DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000426142DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000428599DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000524630DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000525902DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000526357DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000526772DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000526938DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000527467DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000528232DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000528621DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000529526DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000529873DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000529919DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000529986DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000530094DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000530748DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000531014DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000532245DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000532463DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000532649DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000532787DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000532844DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000533667DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000440460ENST00000534579DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000358694DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000360682DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000361332DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000361391DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000361796DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000399039DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000399050DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000415361DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000426142DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000428599DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000524630DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000525902DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000526357DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000526772DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000526938DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000527467DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000528232DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000528621DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000529526DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000529873DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000529919DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000529986DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000530094DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000530748DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000531014DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000532245DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000532463DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000532649DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000532787DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000532844DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000533667DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
5UTR-intronENST00000531396ENST00000534579DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000358694DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000360682DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000361332DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000361391DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000361796DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000399039DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000399050DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000415361DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000426142DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000428599DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000524630DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000525902DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000526357DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000526772DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000526938DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000527467DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000528232DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000528621DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000529526DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000529873DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000529919DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000529986DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000530094DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000530748DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000531014DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000532245DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000532463DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000532649DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000532787DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000532844DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000533667DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000315253ENST00000534579DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000358694DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000360682DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000361332DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000361391DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000361796DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000399039DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000399050DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000415361DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000426142DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000428599DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000524630DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000525902DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000526357DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000526772DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000526938DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000527467DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000528232DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000528621DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000529526DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000529873DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000529919DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000529986DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000530094DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000530748DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000531014DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000532245DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000532463DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000532649DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000532787DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000532844DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000533667DIXDC1chr11

111808191

+CTNND1chr11

57561656

-
intron-intronENST00000529225ENST00000534579DIXDC1chr11

111808191

+CTNND1chr11

57561656

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for DIXDC1-CTNND1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for DIXDC1-CTNND1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:111808191/:57561656)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DIXDC1

Q155Q3

CTNND1

O60716

FUNCTION: Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. {ECO:0000269|PubMed:15262978, ECO:0000269|PubMed:21189423}.FUNCTION: Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:20371349}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for DIXDC1-CTNND1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for DIXDC1-CTNND1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DIXDC1-CTNND1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for DIXDC1-CTNND1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource