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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DLC1-CLASP2 (FusionGDB2 ID:22976)

Fusion Gene Summary for DLC1-CLASP2

check button Fusion gene summary
Fusion gene informationFusion gene name: DLC1-CLASP2
Fusion gene ID: 22976
HgeneTgene
Gene symbol

DLC1

CLASP2

Gene ID

10395

23122

Gene nameDLC1 Rho GTPase activating proteincytoplasmic linker associated protein 2
SynonymsARHGAP7|HP|STARD12|p122-RhoGAP-
Cytomap

8p22

3p22.3

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 7Rho-GTPase-activating protein 7START domain-containing protein 12StAR-related lipid transfer (START) domain containing 12deleted in liver cancer 1 proteindeleted in liver cancer 1 variant 2deleted in liver cancer variaCLIP-associating protein 2CLIP-associating protein CLASP2multiple asters (Mast)-like homolog 2protein Orbit homolog 2
Modification date2020031320200313
UniProtAcc

Q96QB1

O75122

Ensembl transtripts involved in fusion geneENST00000512044, ENST00000276297, 
ENST00000316609, ENST00000358919, 
ENST00000510318, ENST00000511869, 
ENST00000520226, 		ENST00000313350, 
ENST00000333778, ENST00000482896, 
ENST00000487200, ENST00000307312, 
ENST00000359576, ENST00000399362, 
ENST00000461133, ENST00000468888, 
ENST00000480013, ENST00000539981, 
Fusion gene scores* DoF score5 X 4 X 4=8015 X 10 X 9=1350
# samples 515
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1350*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DLC1 [Title/Abstract] AND CLASP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDLC1(13133771)-CLASP2(33592887), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDLC1

GO:0006915

apoptotic process

17292327

HgeneDLC1

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

17888903

HgeneDLC1

GO:0008285

negative regulation of cell proliferation

12545165|17932950

HgeneDLC1

GO:0030336

negative regulation of cell migration

17932950|19158340

HgeneDLC1

GO:0035307

positive regulation of protein dephosphorylation

17292327

HgeneDLC1

GO:0051497

negative regulation of stress fiber assembly

17932950

HgeneDLC1

GO:0051895

negative regulation of focal adhesion assembly

19158340

HgeneDLC1

GO:1900119

positive regulation of execution phase of apoptosis

17888903


check buttonFusion gene breakpoints across DLC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CLASP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-BR-6564-11ADLC1chr8

13133771

-CLASP2chr3

33592887

-


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Fusion Gene ORF analysis for DLC1-CLASP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000512044ENST00000313350DLC1chr8

13133771

-CLASP2chr3

33592887

-
5CDS-intronENST00000512044ENST00000333778DLC1chr8

13133771

-CLASP2chr3

33592887

-
5CDS-intronENST00000512044ENST00000482896DLC1chr8

13133771

-CLASP2chr3

33592887

-
5CDS-intronENST00000512044ENST00000487200DLC1chr8

13133771

-CLASP2chr3

33592887

-
In-frameENST00000512044ENST00000307312DLC1chr8

13133771

-CLASP2chr3

33592887

-
In-frameENST00000512044ENST00000359576DLC1chr8

13133771

-CLASP2chr3

33592887

-
In-frameENST00000512044ENST00000399362DLC1chr8

13133771

-CLASP2chr3

33592887

-
In-frameENST00000512044ENST00000461133DLC1chr8

13133771

-CLASP2chr3

33592887

-
In-frameENST00000512044ENST00000468888DLC1chr8

13133771

-CLASP2chr3

33592887

-
In-frameENST00000512044ENST00000480013DLC1chr8

13133771

-CLASP2chr3

33592887

-
In-frameENST00000512044ENST00000539981DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000276297ENST00000307312DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000276297ENST00000359576DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000276297ENST00000399362DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000276297ENST00000461133DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000276297ENST00000468888DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000276297ENST00000480013DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000276297ENST00000539981DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000316609ENST00000307312DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000316609ENST00000359576DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000316609ENST00000399362DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000316609ENST00000461133DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000316609ENST00000468888DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000316609ENST00000480013DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000316609ENST00000539981DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000358919ENST00000307312DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000358919ENST00000359576DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000358919ENST00000399362DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000358919ENST00000461133DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000358919ENST00000468888DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000358919ENST00000480013DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000358919ENST00000539981DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000510318ENST00000307312DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000510318ENST00000359576DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000510318ENST00000399362DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000510318ENST00000461133DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000510318ENST00000468888DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000510318ENST00000480013DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000510318ENST00000539981DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000511869ENST00000307312DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000511869ENST00000359576DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000511869ENST00000399362DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000511869ENST00000461133DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000511869ENST00000468888DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000511869ENST00000480013DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000511869ENST00000539981DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000520226ENST00000307312DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000520226ENST00000359576DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000520226ENST00000399362DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000520226ENST00000461133DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000520226ENST00000468888DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000520226ENST00000480013DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-3CDSENST00000520226ENST00000539981DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000276297ENST00000313350DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000276297ENST00000333778DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000276297ENST00000482896DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000276297ENST00000487200DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000316609ENST00000313350DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000316609ENST00000333778DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000316609ENST00000482896DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000316609ENST00000487200DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000358919ENST00000313350DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000358919ENST00000333778DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000358919ENST00000482896DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000358919ENST00000487200DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000510318ENST00000313350DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000510318ENST00000333778DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000510318ENST00000482896DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000510318ENST00000487200DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000511869ENST00000313350DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000511869ENST00000333778DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000511869ENST00000482896DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000511869ENST00000487200DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000520226ENST00000313350DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000520226ENST00000333778DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000520226ENST00000482896DLC1chr8

13133771

-CLASP2chr3

33592887

-
intron-intronENST00000520226ENST00000487200DLC1chr8

13133771

-CLASP2chr3

33592887

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000512044DLC1chr813133771-ENST00000468888CLASP2chr333592887-41832852461796516
ENST00000512044DLC1chr813133771-ENST00000399362CLASP2chr333592887-41832852461796516
ENST00000512044DLC1chr813133771-ENST00000539981CLASP2chr333592887-41792852461796516
ENST00000512044DLC1chr813133771-ENST00000359576CLASP2chr333592887-41792852461796516
ENST00000512044DLC1chr813133771-ENST00000307312CLASP2chr333592887-41792852461796516
ENST00000512044DLC1chr813133771-ENST00000480013CLASP2chr333592887-34352852461796516
ENST00000512044DLC1chr813133771-ENST00000461133CLASP2chr333592887-26732852461796516

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000512044ENST00000468888DLC1chr813133771-CLASP2chr333592887-0.000187290.9998128
ENST00000512044ENST00000399362DLC1chr813133771-CLASP2chr333592887-0.000187290.9998128
ENST00000512044ENST00000539981DLC1chr813133771-CLASP2chr333592887-0.000188910.9998111
ENST00000512044ENST00000359576DLC1chr813133771-CLASP2chr333592887-0.000188910.9998111
ENST00000512044ENST00000307312DLC1chr813133771-CLASP2chr333592887-0.000188910.9998111
ENST00000512044ENST00000480013DLC1chr813133771-CLASP2chr333592887-0.0002109980.99978906
ENST00000512044ENST00000461133DLC1chr813133771-CLASP2chr333592887-0.0003013010.99969876

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Fusion Genomic Features for DLC1-CLASP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DLC1-CLASP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:13133771/chr3:33592887)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DLC1

Q96QB1

CLASP2

O75122

FUNCTION: Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422}.FUNCTION: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCLASP2chr8:13133771chr3:33592887ENST000003133500131104_11080432.0Compositional biasNote=Poly-Leu
TgeneCLASP2chr8:13133771chr3:33592887ENST00000313350013310_5870432.0Compositional biasNote=Ser-rich
TgeneCLASP2chr8:13133771chr3:33592887ENST000003133500131017_12940432.0RegionNote=Required for cortical localization
TgeneCLASP2chr8:13133771chr3:33592887ENST0000031335001360_3110432.0RegionTOG 1
TgeneCLASP2chr8:13133771chr3:33592887ENST00000313350013649_8810432.0RegionTOG 2
TgeneCLASP2chr8:13133771chr3:33592887ENST000003133500131054_10910432.0RepeatHEAT 6
TgeneCLASP2chr8:13133771chr3:33592887ENST000003133500131098_11350432.0RepeatHEAT 7
TgeneCLASP2chr8:13133771chr3:33592887ENST000003133500131216_12530432.0RepeatHEAT 8
TgeneCLASP2chr8:13133771chr3:33592887ENST00000313350013173_2080432.0RepeatHEAT 1
TgeneCLASP2chr8:13133771chr3:33592887ENST00000313350013209_2450432.0RepeatHEAT 2
TgeneCLASP2chr8:13133771chr3:33592887ENST00000313350013250_2870432.0RepeatHEAT 3
TgeneCLASP2chr8:13133771chr3:33592887ENST00000313350013710_7470432.0RepeatHEAT 4
TgeneCLASP2chr8:13133771chr3:33592887ENST00000313350013772_8090432.0RepeatHEAT 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDLC1chr8:13133771chr3:33592887ENST00000276297-118741_74701529.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:13133771chr3:33592887ENST00000276297-118868_87401529.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:13133771chr3:33592887ENST00000316609-16741_7470499.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:13133771chr3:33592887ENST00000316609-16868_8740499.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:13133771chr3:33592887ENST00000358919-114741_74701092.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:13133771chr3:33592887ENST00000358919-114868_87401092.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:13133771chr3:33592887ENST00000511869-15741_7470464.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:13133771chr3:33592887ENST00000511869-15868_8740464.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:13133771chr3:33592887ENST00000520226-114741_74701018.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:13133771chr3:33592887ENST00000520226-114868_87401018.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:13133771chr3:33592887ENST00000276297-1181078_128401529.0DomainRho-GAP
HgeneDLC1chr8:13133771chr3:33592887ENST00000276297-1181314_152101529.0DomainSTART
HgeneDLC1chr8:13133771chr3:33592887ENST00000276297-118448_51501529.0DomainNote=SAM
HgeneDLC1chr8:13133771chr3:33592887ENST00000316609-161078_12840499.0DomainRho-GAP
HgeneDLC1chr8:13133771chr3:33592887ENST00000316609-161314_15210499.0DomainSTART
HgeneDLC1chr8:13133771chr3:33592887ENST00000316609-16448_5150499.0DomainNote=SAM
HgeneDLC1chr8:13133771chr3:33592887ENST00000358919-1141078_128401092.0DomainRho-GAP
HgeneDLC1chr8:13133771chr3:33592887ENST00000358919-1141314_152101092.0DomainSTART
HgeneDLC1chr8:13133771chr3:33592887ENST00000358919-114448_51501092.0DomainNote=SAM
HgeneDLC1chr8:13133771chr3:33592887ENST00000511869-151078_12840464.0DomainRho-GAP
HgeneDLC1chr8:13133771chr3:33592887ENST00000511869-151314_15210464.0DomainSTART
HgeneDLC1chr8:13133771chr3:33592887ENST00000511869-15448_5150464.0DomainNote=SAM
HgeneDLC1chr8:13133771chr3:33592887ENST00000520226-1141078_128401018.0DomainRho-GAP
HgeneDLC1chr8:13133771chr3:33592887ENST00000520226-1141314_152101018.0DomainSTART
HgeneDLC1chr8:13133771chr3:33592887ENST00000520226-114448_51501018.0DomainNote=SAM
HgeneDLC1chr8:13133771chr3:33592887ENST00000276297-1181051_107301529.0RegionNote=Polybasic cluster (PBR)
HgeneDLC1chr8:13133771chr3:33592887ENST00000276297-118710_88401529.0RegionNote=Focal adhesion-targeting (FAT)
HgeneDLC1chr8:13133771chr3:33592887ENST00000316609-161051_10730499.0RegionNote=Polybasic cluster (PBR)
HgeneDLC1chr8:13133771chr3:33592887ENST00000316609-16710_8840499.0RegionNote=Focal adhesion-targeting (FAT)
HgeneDLC1chr8:13133771chr3:33592887ENST00000358919-1141051_107301092.0RegionNote=Polybasic cluster (PBR)
HgeneDLC1chr8:13133771chr3:33592887ENST00000358919-114710_88401092.0RegionNote=Focal adhesion-targeting (FAT)
HgeneDLC1chr8:13133771chr3:33592887ENST00000511869-151051_10730464.0RegionNote=Polybasic cluster (PBR)
HgeneDLC1chr8:13133771chr3:33592887ENST00000511869-15710_8840464.0RegionNote=Focal adhesion-targeting (FAT)
HgeneDLC1chr8:13133771chr3:33592887ENST00000520226-1141051_107301018.0RegionNote=Polybasic cluster (PBR)
HgeneDLC1chr8:13133771chr3:33592887ENST00000520226-114710_88401018.0RegionNote=Focal adhesion-targeting (FAT)


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Fusion Gene Sequence for DLC1-CLASP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22976_22976_1_DLC1-CLASP2_DLC1_chr8_13133771_ENST00000512044_CLASP2_chr3_33592887_ENST00000307312_length(transcript)=4179nt_BP=285nt
AGTTGGCGCTTCCCGGGGCCGCAGTGCCAGCCGCAATGCCGGCCTCCTGAAGGCAGGCGACAGCCTGCGGCCGGGAGCACAGCGCGGGGC
GGAGTACCGAGGCATGGTCGCGGCGCCCGGGCTGCGCTGAAGGCGTCTGCGAGCGGATGGGGGACCCCAAGGCCCACGTGATGGCGCGCC
CCCTGCGAGCCCCTCTCCGGAGGTCCTTTAGCGATCACATCAGGGACTCCACGGCCAGAGCCCTGGATGTCATTTGGAAAAACACTAGAG
ACAGACGGCTGGCAGGTGAAGGTTGCTATCCTTAAATACATAGAAACTCTGGCCAAACAGATGGATCCAGGAGATTTTATAAATTCCAGT
GAAACTCGCCTAGCAGTGTCTCGGGTCATCACTTGGACAACAGAACCCAAAAGTTCTGATGTTCGGAAGGCAGCACAGTCAGTGCTGATT
TCATTATTTGAACTCAATACCCCAGAGTTTACAATGTTATTAGGAGCTTTACCAAAAACTTTTCAGGATGGTGCTACCAAGCTTCTTCAT
AATCACCTTCGAAACACTGGCAATGGAACCCAGAGTTCCATGGGGAGTCCTTTGACAAGACCAACACCACGATCACCAGCTAACTGGTCC
AGTCCTCTTACTTCTCCTACCAATACATCACAGAATACTTTATCTCCAAGTGCATTTGATTATGACACAGAAAATATGAACTCTGAAGAT
ATTTATAGCTCTCTTAGAGGTGTCACTGAAGCAATCCAGAATTTCAGCTTCCGTAGCCAAGAAGATATGAATGAGCCATTGAAAAGGGAT
TCTAAAAAAGATGATGGCGATTCAATGTGTGGTGGTCCTGGGATGTCTGACCCAAGAGCAGGAGGTGATGCTACTGACTCAAGTCAAACA
GCTCTTGATAATAAAGCTTCATTGCTCCATTCAATGCCTACTCACTCCTCTCCACGCTCTCGAGACTATAATCCATATAACTATTCAGAT
AGCATCAGTCCCTTCAACAAGTCTGCCCTCAAGGAAGCCATGTTTGATGATGATGCTGACCAGTTTCCTGACGATCTTTCCCTAGATCAT
TCTGACCTAGTTGCAGAGTTGTTGAAGGAGCTGTCTAACCATAATGAGCGTGTAGAAGAAAGAAAAATTGCCCTCTATGAACTTATGAAA
CTGACACAGGAAGAATCTTTTAGTGTTTGGGATGAACACTTCAAAACAATATTGCTTTTATTGCTTGAAACGCTTGGAGATAAAGAGCCT
ACAATCAGGGCTTTGGCATTAAAGGTTTTAAGAGAAATCCTAAGGCATCAACCAGCAAGATTTAAAAACTATGCAGAATTGACTGTCATG
AAAACATTGGAAGCACATAAAGATCCTCATAAGGAGGTGGTGAGATCTGCTGAGGAAGCGGCATCAGTGTTGGCCACTTCAATTAGTCCA
GAGCAGTGCATCAAAGTGCTTTGTCCTATCATTCAAACTGCAGACTACCCAATTAATCTGGCTGCAATCAAAATGCAAACAAAAGTGATA
GAGAGAGTGTCCAAGGAAACCCTAAACCTGCTTTTGCCAGAGATTATGCCAGGTCTAATACAGGGTTATGATAATTCAGAGAGCAGTGTT
CGGAAAGCTTGTGTCTTCTGCCTGGTGGCTGTTCATGCGGTAATTGGTGATGAACTAAAACCACATCTCAGTCAACTTACTGGCAGTAAA
ATGAAGCTACTGAATCTTTACATCAAACGTGCACAAACAGGTTCTGGAGGAGCTGATCCCACTACTGATGTTTCTGGACAAAGTTAGTGA
AGCTCATCACAGCGAACCAGGTCTCTCAAAAGAAAGGACAGATAGACCACCCTCATCAATGAAAGGAAGTTCTCAAACACATCCTTTGGA
ACTTACTATTGTTTCCCAGTTTTAGTTTTTTGTTTCGTTTCGTTTTGTATTTTCTGTAACAGAGGACTATCCTCAGTCTGCATGTAACTT
TTATGATAGTTATTCCAAATTCAAGAAGAAGCAGTATTAACATCAATTGATCGACACAAAGTAATTTTTAATTTAATTCATCATTTCACA
TGTTTGTACTTTGTCTTCCCATTAACCTTTGCCAGTGTTATGATTGTATAAATTTTTTTAAATGCTGGTTAAACAGGAATGCTTAAAGCT
TTAAAAGTTTAACAGTCTAAAACATTTTTGCTTTTATTCAACTGCAGAATAATATTTTTATTGCTACTTTGAGTTTTGTTTCGTATCATG
TCCTATGCTAGAAATATTTAAATGATGTGAAACAAAGCAGGACTAATTTGAACTACAGCTGGACTCCGTTTGTGTGATGGTGATACATGT
CATTAGTTGCAACTTCTTTGGGGTGATCTATAGTTTGAAAACTAAAACCTCAAAGACAGATGTTACAGAATCAGCCAGTTCTGTAAAACT
GATATTGTCTATTGGTTATTGATCTTGCCATCTTTATTTAAAACCATGTCCCTTCTATGATCCCTTAAGAAAGCTGCACCAAATCATCTG
CCTGTTTTTTCTTGATACTTACTGAAATAGAAGGTTTTATTGCAGGGTTTATTTTGGTTTGTTTATATCTTTGTTGTGAATGATGCTTTT
TTGTATTTATTAATATCAAATTCACTTATGAATAAACTTGATAATGGAAACGGACAAAAAAAATCAAGTGCGTGTGTGTCCTTGACCGTC
TTCTGTTTCTCACGTAATAAACAAATTATCGAGACATGGGAGTGACCAGCACCTTTTCTTTAAATGGTGGAACCTGGTTTCCTTTTACCA
TGAAATTGTCTTACTTGAAAATATTGATCCTGATGAGAGAGAAGATGGTGCCAAGGCTGTCTTTGTATAATGGGCTCAAATTCTCTACCT
CTTCAGGGCTAATACTTTTAACTGAGCTGCTGCCTATAGTGTCTTTTGGAAAACTACTTAAAGGGTGATTTTCTGTTACTTTTTAGCAAA
TTTTTTTAATCACCTCTTGCTACACCCATTCTTTTCATGTGCAGCCGACTCAAAAATTACCAGTTTTGGTGAAAGGCTAAATTAGATAAT
TTGGAACCAGGATACTAATGATTTCTCATCTTTACTTTTTTTTAATCCTAATATAAAGTGAATTTGATTGAAAAGGCAAATAGCTATTAG
GGAAGCAGTTTGCCATTGTTGCAGAGTTATCTGTACTTTGTTTAACTGAAAAAAATGTAGAAATATATGTAAAGAATTTAAGACAAGAGT
ACTGAATGGATGATTTGTCATAGGCTTTCCCCTTTCTTTCTGTTCTAGCAGCAGGAAAAGTTTCTCTATATCCTCTCCCTCTACCTGTAA
CAATTTTGTTTTCTACTGTTAATTACATTGTGTATTTATAGTTCTATGCTTACTGTTGTGCATATACTGGCAATAAAACTGTACATAACA
TTACTTGAAAAAGTTAATAATGTATATCAGTTTTTCTGTCTCACTGTGTAACAAGTCACTCAGTTTTATTTTAACTTTAGACGGTCTTGT
ATCAGTGGTGGTCTCTTGAATTTTGTAAGTTCATCTGAGGAGAAAAGATTTTTCAGGTGTAGCTACCACAATCAAAGGTATATAGCTACA
TACGCATGTATATATTACAGCTTATCTGTAAGAAGAAAATGCATTTTAAACACAACTCTTCTCAGTAGCATTTTATGACCTTTGGATATG
TTTGTAATCATTTCGAATCAAAATATTGATTTAATTTTGACCTCTGGTTTAAGATACTGCTTTAACTACTGTTGACAACCAAGTAGAGTG
ACTTAAGCTGAACAGTAACTAACTGGAAAATTAGATAAGCACCTGGCATCTAATGGCAGGCAGGCACTCAAGAAATGAATTAACTACATA
ATGGAAAAGTATGGTTTAATGTGTCCAAATGAAAGCTAGTAGATGTAAACATGGAAAAATTGTGTTTACAATTTTATAATCTCAGTTGAT
AAGACTATAAGAAAGCTGATTATTTAAATCACTATATACAATACACCCTTAATTTGTTCATTCCAGAAACATACTGAGATGTCAGCTACT
TAAAAATGGTCACAAAAAGCTACTGTTTATATTTTTCCTCCTGCTATTCTCTCCCAAATTAATTATTAATAAGTGTTGTTCATTTACTGC

>22976_22976_1_DLC1-CLASP2_DLC1_chr8_13133771_ENST00000512044_CLASP2_chr3_33592887_ENST00000307312_length(amino acids)=516AA_BP=12
MSFGKTLETDGWQVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQ
DGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQED
MNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQF
PDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFK
NYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQG

--------------------------------------------------------------
>22976_22976_2_DLC1-CLASP2_DLC1_chr8_13133771_ENST00000512044_CLASP2_chr3_33592887_ENST00000359576_length(transcript)=4179nt_BP=285nt
AGTTGGCGCTTCCCGGGGCCGCAGTGCCAGCCGCAATGCCGGCCTCCTGAAGGCAGGCGACAGCCTGCGGCCGGGAGCACAGCGCGGGGC
GGAGTACCGAGGCATGGTCGCGGCGCCCGGGCTGCGCTGAAGGCGTCTGCGAGCGGATGGGGGACCCCAAGGCCCACGTGATGGCGCGCC
CCCTGCGAGCCCCTCTCCGGAGGTCCTTTAGCGATCACATCAGGGACTCCACGGCCAGAGCCCTGGATGTCATTTGGAAAAACACTAGAG
ACAGACGGCTGGCAGGTGAAGGTTGCTATCCTTAAATACATAGAAACTCTGGCCAAACAGATGGATCCAGGAGATTTTATAAATTCCAGT
GAAACTCGCCTAGCAGTGTCTCGGGTCATCACTTGGACAACAGAACCCAAAAGTTCTGATGTTCGGAAGGCAGCACAGTCAGTGCTGATT
TCATTATTTGAACTCAATACCCCAGAGTTTACAATGTTATTAGGAGCTTTACCAAAAACTTTTCAGGATGGTGCTACCAAGCTTCTTCAT
AATCACCTTCGAAACACTGGCAATGGAACCCAGAGTTCCATGGGGAGTCCTTTGACAAGACCAACACCACGATCACCAGCTAACTGGTCC
AGTCCTCTTACTTCTCCTACCAATACATCACAGAATACTTTATCTCCAAGTGCATTTGATTATGACACAGAAAATATGAACTCTGAAGAT
ATTTATAGCTCTCTTAGAGGTGTCACTGAAGCAATCCAGAATTTCAGCTTCCGTAGCCAAGAAGATATGAATGAGCCATTGAAAAGGGAT
TCTAAAAAAGATGATGGCGATTCAATGTGTGGTGGTCCTGGGATGTCTGACCCAAGAGCAGGAGGTGATGCTACTGACTCAAGTCAAACA
GCTCTTGATAATAAAGCTTCATTGCTCCATTCAATGCCTACTCACTCCTCTCCACGCTCTCGAGACTATAATCCATATAACTATTCAGAT
AGCATCAGTCCCTTCAACAAGTCTGCCCTCAAGGAAGCCATGTTTGATGATGATGCTGACCAGTTTCCTGACGATCTTTCCCTAGATCAT
TCTGACCTAGTTGCAGAGTTGTTGAAGGAGCTGTCTAACCATAATGAGCGTGTAGAAGAAAGAAAAATTGCCCTCTATGAACTTATGAAA
CTGACACAGGAAGAATCTTTTAGTGTTTGGGATGAACACTTCAAAACAATATTGCTTTTATTGCTTGAAACGCTTGGAGATAAAGAGCCT
ACAATCAGGGCTTTGGCATTAAAGGTTTTAAGAGAAATCCTAAGGCATCAACCAGCAAGATTTAAAAACTATGCAGAATTGACTGTCATG
AAAACATTGGAAGCACATAAAGATCCTCATAAGGAGGTGGTGAGATCTGCTGAGGAAGCGGCATCAGTGTTGGCCACTTCAATTAGTCCA
GAGCAGTGCATCAAAGTGCTTTGTCCTATCATTCAAACTGCAGACTACCCAATTAATCTGGCTGCAATCAAAATGCAAACAAAAGTGATA
GAGAGAGTGTCCAAGGAAACCCTAAACCTGCTTTTGCCAGAGATTATGCCAGGTCTAATACAGGGTTATGATAATTCAGAGAGCAGTGTT
CGGAAAGCTTGTGTCTTCTGCCTGGTGGCTGTTCATGCGGTAATTGGTGATGAACTAAAACCACATCTCAGTCAACTTACTGGCAGTAAA
ATGAAGCTACTGAATCTTTACATCAAACGTGCACAAACAGGTTCTGGAGGAGCTGATCCCACTACTGATGTTTCTGGACAAAGTTAGTGA
AGCTCATCACAGCGAACCAGGTCTCTCAAAAGAAAGGACAGATAGACCACCCTCATCAATGAAAGGAAGTTCTCAAACACATCCTTTGGA
ACTTACTATTGTTTCCCAGTTTTAGTTTTTTGTTTCGTTTCGTTTTGTATTTTCTGTAACAGAGGACTATCCTCAGTCTGCATGTAACTT
TTATGATAGTTATTCCAAATTCAAGAAGAAGCAGTATTAACATCAATTGATCGACACAAAGTAATTTTTAATTTAATTCATCATTTCACA
TGTTTGTACTTTGTCTTCCCATTAACCTTTGCCAGTGTTATGATTGTATAAATTTTTTTAAATGCTGGTTAAACAGGAATGCTTAAAGCT
TTAAAAGTTTAACAGTCTAAAACATTTTTGCTTTTATTCAACTGCAGAATAATATTTTTATTGCTACTTTGAGTTTTGTTTCGTATCATG
TCCTATGCTAGAAATATTTAAATGATGTGAAACAAAGCAGGACTAATTTGAACTACAGCTGGACTCCGTTTGTGTGATGGTGATACATGT
CATTAGTTGCAACTTCTTTGGGGTGATCTATAGTTTGAAAACTAAAACCTCAAAGACAGATGTTACAGAATCAGCCAGTTCTGTAAAACT
GATATTGTCTATTGGTTATTGATCTTGCCATCTTTATTTAAAACCATGTCCCTTCTATGATCCCTTAAGAAAGCTGCACCAAATCATCTG
CCTGTTTTTTCTTGATACTTACTGAAATAGAAGGTTTTATTGCAGGGTTTATTTTGGTTTGTTTATATCTTTGTTGTGAATGATGCTTTT
TTGTATTTATTAATATCAAATTCACTTATGAATAAACTTGATAATGGAAACGGACAAAAAAAATCAAGTGCGTGTGTGTCCTTGACCGTC
TTCTGTTTCTCACGTAATAAACAAATTATCGAGACATGGGAGTGACCAGCACCTTTTCTTTAAATGGTGGAACCTGGTTTCCTTTTACCA
TGAAATTGTCTTACTTGAAAATATTGATCCTGATGAGAGAGAAGATGGTGCCAAGGCTGTCTTTGTATAATGGGCTCAAATTCTCTACCT
CTTCAGGGCTAATACTTTTAACTGAGCTGCTGCCTATAGTGTCTTTTGGAAAACTACTTAAAGGGTGATTTTCTGTTACTTTTTAGCAAA
TTTTTTTAATCACCTCTTGCTACACCCATTCTTTTCATGTGCAGCCGACTCAAAAATTACCAGTTTTGGTGAAAGGCTAAATTAGATAAT
TTGGAACCAGGATACTAATGATTTCTCATCTTTACTTTTTTTTAATCCTAATATAAAGTGAATTTGATTGAAAAGGCAAATAGCTATTAG
GGAAGCAGTTTGCCATTGTTGCAGAGTTATCTGTACTTTGTTTAACTGAAAAAAATGTAGAAATATATGTAAAGAATTTAAGACAAGAGT
ACTGAATGGATGATTTGTCATAGGCTTTCCCCTTTCTTTCTGTTCTAGCAGCAGGAAAAGTTTCTCTATATCCTCTCCCTCTACCTGTAA
CAATTTTGTTTTCTACTGTTAATTACATTGTGTATTTATAGTTCTATGCTTACTGTTGTGCATATACTGGCAATAAAACTGTACATAACA
TTACTTGAAAAAGTTAATAATGTATATCAGTTTTTCTGTCTCACTGTGTAACAAGTCACTCAGTTTTATTTTAACTTTAGACGGTCTTGT
ATCAGTGGTGGTCTCTTGAATTTTGTAAGTTCATCTGAGGAGAAAAGATTTTTCAGGTGTAGCTACCACAATCAAAGGTATATAGCTACA
TACGCATGTATATATTACAGCTTATCTGTAAGAAGAAAATGCATTTTAAACACAACTCTTCTCAGTAGCATTTTATGACCTTTGGATATG
TTTGTAATCATTTCGAATCAAAATATTGATTTAATTTTGACCTCTGGTTTAAGATACTGCTTTAACTACTGTTGACAACCAAGTAGAGTG
ACTTAAGCTGAACAGTAACTAACTGGAAAATTAGATAAGCACCTGGCATCTAATGGCAGGCAGGCACTCAAGAAATGAATTAACTACATA
ATGGAAAAGTATGGTTTAATGTGTCCAAATGAAAGCTAGTAGATGTAAACATGGAAAAATTGTGTTTACAATTTTATAATCTCAGTTGAT
AAGACTATAAGAAAGCTGATTATTTAAATCACTATATACAATACACCCTTAATTTGTTCATTCCAGAAACATACTGAGATGTCAGCTACT
TAAAAATGGTCACAAAAAGCTACTGTTTATATTTTTCCTCCTGCTATTCTCTCCCAAATTAATTATTAATAAGTGTTGTTCATTTACTGC

>22976_22976_2_DLC1-CLASP2_DLC1_chr8_13133771_ENST00000512044_CLASP2_chr3_33592887_ENST00000359576_length(amino acids)=516AA_BP=12
MSFGKTLETDGWQVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQ
DGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQED
MNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQF
PDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFK
NYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQG

--------------------------------------------------------------
>22976_22976_3_DLC1-CLASP2_DLC1_chr8_13133771_ENST00000512044_CLASP2_chr3_33592887_ENST00000399362_length(transcript)=4183nt_BP=285nt
AGTTGGCGCTTCCCGGGGCCGCAGTGCCAGCCGCAATGCCGGCCTCCTGAAGGCAGGCGACAGCCTGCGGCCGGGAGCACAGCGCGGGGC
GGAGTACCGAGGCATGGTCGCGGCGCCCGGGCTGCGCTGAAGGCGTCTGCGAGCGGATGGGGGACCCCAAGGCCCACGTGATGGCGCGCC
CCCTGCGAGCCCCTCTCCGGAGGTCCTTTAGCGATCACATCAGGGACTCCACGGCCAGAGCCCTGGATGTCATTTGGAAAAACACTAGAG
ACAGACGGCTGGCAGGTGAAGGTTGCTATCCTTAAATACATAGAAACTCTGGCCAAACAGATGGATCCAGGAGATTTTATAAATTCCAGT
GAAACTCGCCTAGCAGTGTCTCGGGTCATCACTTGGACAACAGAACCCAAAAGTTCTGATGTTCGGAAGGCAGCACAGTCAGTGCTGATT
TCATTATTTGAACTCAATACCCCAGAGTTTACAATGTTATTAGGAGCTTTACCAAAAACTTTTCAGGATGGTGCTACCAAGCTTCTTCAT
AATCACCTTCGAAACACTGGCAATGGAACCCAGAGTTCCATGGGGAGTCCTTTGACAAGACCAACACCACGATCACCAGCTAACTGGTCC
AGTCCTCTTACTTCTCCTACCAATACATCACAGAATACTTTATCTCCAAGTGCATTTGATTATGACACAGAAAATATGAACTCTGAAGAT
ATTTATAGCTCTCTTAGAGGTGTCACTGAAGCAATCCAGAATTTCAGCTTCCGTAGCCAAGAAGATATGAATGAGCCATTGAAAAGGGAT
TCTAAAAAAGATGATGGCGATTCAATGTGTGGTGGTCCTGGGATGTCTGACCCAAGAGCAGGAGGTGATGCTACTGACTCAAGTCAAACA
GCTCTTGATAATAAAGCTTCATTGCTCCATTCAATGCCTACTCACTCCTCTCCACGCTCTCGAGACTATAATCCATATAACTATTCAGAT
AGCATCAGTCCCTTCAACAAGTCTGCCCTCAAGGAAGCCATGTTTGATGATGATGCTGACCAGTTTCCTGACGATCTTTCCCTAGATCAT
TCTGACCTAGTTGCAGAGTTGTTGAAGGAGCTGTCTAACCATAATGAGCGTGTAGAAGAAAGAAAAATTGCCCTCTATGAACTTATGAAA
CTGACACAGGAAGAATCTTTTAGTGTTTGGGATGAACACTTCAAAACAATATTGCTTTTATTGCTTGAAACGCTTGGAGATAAAGAGCCT
ACAATCAGGGCTTTGGCATTAAAGGTTTTAAGAGAAATCCTAAGGCATCAACCAGCAAGATTTAAAAACTATGCAGAATTGACTGTCATG
AAAACATTGGAAGCACATAAAGATCCTCATAAGGAGGTGGTGAGATCTGCTGAGGAAGCGGCATCAGTGTTGGCCACTTCAATTAGTCCA
GAGCAGTGCATCAAAGTGCTTTGTCCTATCATTCAAACTGCAGACTACCCAATTAATCTGGCTGCAATCAAAATGCAAACAAAAGTGATA
GAGAGAGTGTCCAAGGAAACCCTAAACCTGCTTTTGCCAGAGATTATGCCAGGTCTAATACAGGGTTATGATAATTCAGAGAGCAGTGTT
CGGAAAGCTTGTGTCTTCTGCCTGGTGGCTGTTCATGCGGTAATTGGTGATGAACTAAAACCACATCTCAGTCAACTTACTGGCAGTAAA
ATGAAGCTACTGAATCTTTACATCAAACGTGCACAAACAGGTTCTGGAGGAGCTGATCCCACTACTGATGTTTCTGGACAAAGTTAGTGA
AGCTCATCACAGCGAACCAGGTCTCTCAAAAGAAAGGACAGATAGACCACCCTCATCAATGAAAGGAAGTTCTCAAACACATCCTTTGGA
ACTTACTATTGTTTCCCAGTTTTAGTTTTTTGTTTCGTTTCGTTTTGTATTTTCTGTAACAGAGGACTATCCTCAGTCTGCATGTAACTT
TTATGATAGTTATTCCAAATTCAAGAAGAAGCAGTATTAACATCAATTGATCGACACAAAGTAATTTTTAATTTAATTCATCATTTCACA
TGTTTGTACTTTGTCTTCCCATTAACCTTTGCCAGTGTTATGATTGTATAAATTTTTTTAAATGCTGGTTAAACAGGAATGCTTAAAGCT
TTAAAAGTTTAACAGTCTAAAACATTTTTGCTTTTATTCAACTGCAGAATAATATTTTTATTGCTACTTTGAGTTTTGTTTCGTATCATG
TCCTATGCTAGAAATATTTAAATGATGTGAAACAAAGCAGGACTAATTTGAACTACAGCTGGACTCCGTTTGTGTGATGGTGATACATGT
CATTAGTTGCAACTTCTTTGGGGTGATCTATAGTTTGAAAACTAAAACCTCAAAGACAGATGTTACAGAATCAGCCAGTTCTGTAAAACT
GATATTGTCTATTGGTTATTGATCTTGCCATCTTTATTTAAAACCATGTCCCTTCTATGATCCCTTAAGAAAGCTGCACCAAATCATCTG
CCTGTTTTTTCTTGATACTTACTGAAATAGAAGGTTTTATTGCAGGGTTTATTTTGGTTTGTTTATATCTTTGTTGTGAATGATGCTTTT
TTGTATTTATTAATATCAAATTCACTTATGAATAAACTTGATAATGGAAACGGACAAAAAAAATCAAGTGCGTGTGTGTCCTTGACCGTC
TTCTGTTTCTCACGTAATAAACAAATTATCGAGACATGGGAGTGACCAGCACCTTTTCTTTAAATGGTGGAACCTGGTTTCCTTTTACCA
TGAAATTGTCTTACTTGAAAATATTGATCCTGATGAGAGAGAAGATGGTGCCAAGGCTGTCTTTGTATAATGGGCTCAAATTCTCTACCT
CTTCAGGGCTAATACTTTTAACTGAGCTGCTGCCTATAGTGTCTTTTGGAAAACTACTTAAAGGGTGATTTTCTGTTACTTTTTAGCAAA
TTTTTTTAATCACCTCTTGCTACACCCATTCTTTTCATGTGCAGCCGACTCAAAAATTACCAGTTTTGGTGAAAGGCTAAATTAGATAAT
TTGGAACCAGGATACTAATGATTTCTCATCTTTACTTTTTTTTAATCCTAATATAAAGTGAATTTGATTGAAAAGGCAAATAGCTATTAG
GGAAGCAGTTTGCCATTGTTGCAGAGTTATCTGTACTTTGTTTAACTGAAAAAAATGTAGAAATATATGTAAAGAATTTAAGACAAGAGT
ACTGAATGGATGATTTGTCATAGGCTTTCCCCTTTCTTTCTGTTCTAGCAGCAGGAAAAGTTTCTCTATATCCTCTCCCTCTACCTGTAA
CAATTTTGTTTTCTACTGTTAATTACATTGTGTATTTATAGTTCTATGCTTACTGTTGTGCATATACTGGCAATAAAACTGTACATAACA
TTACTTGAAAAAGTTAATAATGTATATCAGTTTTTCTGTCTCACTGTGTAACAAGTCACTCAGTTTTATTTTAACTTTAGACGGTCTTGT
ATCAGTGGTGGTCTCTTGAATTTTGTAAGTTCATCTGAGGAGAAAAGATTTTTCAGGTGTAGCTACCACAATCAAAGGTATATAGCTACA
TACGCATGTATATATTACAGCTTATCTGTAAGAAGAAAATGCATTTTAAACACAACTCTTCTCAGTAGCATTTTATGACCTTTGGATATG
TTTGTAATCATTTCGAATCAAAATATTGATTTAATTTTGACCTCTGGTTTAAGATACTGCTTTAACTACTGTTGACAACCAAGTAGAGTG
ACTTAAGCTGAACAGTAACTAACTGGAAAATTAGATAAGCACCTGGCATCTAATGGCAGGCAGGCACTCAAGAAATGAATTAACTACATA
ATGGAAAAGTATGGTTTAATGTGTCCAAATGAAAGCTAGTAGATGTAAACATGGAAAAATTGTGTTTACAATTTTATAATCTCAGTTGAT
AAGACTATAAGAAAGCTGATTATTTAAATCACTATATACAATACACCCTTAATTTGTTCATTCCAGAAACATACTGAGATGTCAGCTACT
TAAAAATGGTCACAAAAAGCTACTGTTTATATTTTTCCTCCTGCTATTCTCTCCCAAATTAATTATTAATAAGTGTTGTTCATTTACTGC

>22976_22976_3_DLC1-CLASP2_DLC1_chr8_13133771_ENST00000512044_CLASP2_chr3_33592887_ENST00000399362_length(amino acids)=516AA_BP=12
MSFGKTLETDGWQVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQ
DGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQED
MNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQF
PDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFK
NYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQG

--------------------------------------------------------------
>22976_22976_4_DLC1-CLASP2_DLC1_chr8_13133771_ENST00000512044_CLASP2_chr3_33592887_ENST00000461133_length(transcript)=2673nt_BP=285nt
AGTTGGCGCTTCCCGGGGCCGCAGTGCCAGCCGCAATGCCGGCCTCCTGAAGGCAGGCGACAGCCTGCGGCCGGGAGCACAGCGCGGGGC
GGAGTACCGAGGCATGGTCGCGGCGCCCGGGCTGCGCTGAAGGCGTCTGCGAGCGGATGGGGGACCCCAAGGCCCACGTGATGGCGCGCC
CCCTGCGAGCCCCTCTCCGGAGGTCCTTTAGCGATCACATCAGGGACTCCACGGCCAGAGCCCTGGATGTCATTTGGAAAAACACTAGAG
ACAGACGGCTGGCAGGTGAAGGTTGCTATCCTTAAATACATAGAAACTCTGGCCAAACAGATGGATCCAGGAGATTTTATAAATTCCAGT
GAAACTCGCCTAGCAGTGTCTCGGGTCATCACTTGGACAACAGAACCCAAAAGTTCTGATGTTCGGAAGGCAGCACAGTCAGTGCTGATT
TCATTATTTGAACTCAATACCCCAGAGTTTACAATGTTATTAGGAGCTTTACCAAAAACTTTTCAGGATGGTGCTACCAAGCTTCTTCAT
AATCACCTTCGAAACACTGGCAATGGAACCCAGAGTTCCATGGGGAGTCCTTTGACAAGACCAACACCACGATCACCAGCTAACTGGTCC
AGTCCTCTTACTTCTCCTACCAATACATCACAGAATACTTTATCTCCAAGTGCATTTGATTATGACACAGAAAATATGAACTCTGAAGAT
ATTTATAGCTCTCTTAGAGGTGTCACTGAAGCAATCCAGAATTTCAGCTTCCGTAGCCAAGAAGATATGAATGAGCCATTGAAAAGGGAT
TCTAAAAAAGATGATGGCGATTCAATGTGTGGTGGTCCTGGGATGTCTGACCCAAGAGCAGGAGGTGATGCTACTGACTCAAGTCAAACA
GCTCTTGATAATAAAGCTTCATTGCTCCATTCAATGCCTACTCACTCCTCTCCACGCTCTCGAGACTATAATCCATATAACTATTCAGAT
AGCATCAGTCCCTTCAACAAGTCTGCCCTCAAGGAAGCCATGTTTGATGATGATGCTGACCAGTTTCCTGACGATCTTTCCCTAGATCAT
TCTGACCTAGTTGCAGAGTTGTTGAAGGAGCTGTCTAACCATAATGAGCGTGTAGAAGAAAGAAAAATTGCCCTCTATGAACTTATGAAA
CTGACACAGGAAGAATCTTTTAGTGTTTGGGATGAACACTTCAAAACAATATTGCTTTTATTGCTTGAAACGCTTGGAGATAAAGAGCCT
ACAATCAGGGCTTTGGCATTAAAGGTTTTAAGAGAAATCCTAAGGCATCAACCAGCAAGATTTAAAAACTATGCAGAATTGACTGTCATG
AAAACATTGGAAGCACATAAAGATCCTCATAAGGAGGTGGTGAGATCTGCTGAGGAAGCGGCATCAGTGTTGGCCACTTCAATTAGTCCA
GAGCAGTGCATCAAAGTGCTTTGTCCTATCATTCAAACTGCAGACTACCCAATTAATCTGGCTGCAATCAAAATGCAAACAAAAGTGATA
GAGAGAGTGTCCAAGGAAACCCTAAACCTGCTTTTGCCAGAGATTATGCCAGGTCTAATACAGGGTTATGATAATTCAGAGAGCAGTGTT
CGGAAAGCTTGTGTCTTCTGCCTGGTGGCTGTTCATGCGGTAATTGGTGATGAACTAAAACCACATCTCAGTCAACTTACTGGCAGTAAA
ATGAAGCTACTGAATCTTTACATCAAACGTGCACAAACAGGTTCTGGAGGAGCTGATCCCACTACTGATGTTTCTGGACAAAGTTAGTGA
AGCTCATCACAGCGAACCAGGTCTCTCAAAAGAAAGGACAGATAGACCACCCTCATCAATGAAAGGAAGTTCTCAAACACATCCTTTGGA
ACTTACTATTGTTTCCCAGTTTTAGTTTTTTGTTTCGTTTCGTTTTGTATTTTCTGTAACAGAGGACTATCCTCAGTCTGCATGTAACTT
TTATGATAGTTATTCCAAATTCAAGAAGAAGCAGTATTAACATCAATTGATCGACACAAAGTAATTTTTAATTTAATTCATCATTTCACA
TGTTTGTACTTTGTCTTCCCATTAACCTTTGCCAGTGTTATGATTGTATAAATTTTTTTAAATGCTGGTTAAACAGGAATGCTTAAAGCT
TTAAAAGTTTAACAGTCTAAAACATTTTTGCTTTTATTCAACTGCAGAATAATATTTTTATTGCTACTTTGAGTTTTGTTTCGTATCATG
TCCTATGCTAGAAATATTTAAATGATGTGAAACAAAGCAGGACTAATTTGAACTACAGCTGGACTCCGTTTGTGTGATGGTGATACATGT
CATTAGTTGCAACTTCTTTGGGGTGATCTATAGTTTGAAAACTAAAACCTCAAAGACAGATGTTACAGAATCAGCCAGTTCTGTAAAACT
GATATTGTCTATTGGTTATTGATCTTGCCATCTTTATTTAAAACCATGTCCCTTCTATGATCCCTTAAGAAAGCTGCACCAAATCATCTG
CCTGTTTTTTCTTGATACTTACTGAAATAGAAGGTTTTATTGCAGGGTTTATTTTGGTTTGTTTATATCTTTGTTGTGAATGATGCTTTT

>22976_22976_4_DLC1-CLASP2_DLC1_chr8_13133771_ENST00000512044_CLASP2_chr3_33592887_ENST00000461133_length(amino acids)=516AA_BP=12
MSFGKTLETDGWQVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQ
DGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQED
MNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQF
PDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFK
NYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQG

--------------------------------------------------------------
>22976_22976_5_DLC1-CLASP2_DLC1_chr8_13133771_ENST00000512044_CLASP2_chr3_33592887_ENST00000468888_length(transcript)=4183nt_BP=285nt
AGTTGGCGCTTCCCGGGGCCGCAGTGCCAGCCGCAATGCCGGCCTCCTGAAGGCAGGCGACAGCCTGCGGCCGGGAGCACAGCGCGGGGC
GGAGTACCGAGGCATGGTCGCGGCGCCCGGGCTGCGCTGAAGGCGTCTGCGAGCGGATGGGGGACCCCAAGGCCCACGTGATGGCGCGCC
CCCTGCGAGCCCCTCTCCGGAGGTCCTTTAGCGATCACATCAGGGACTCCACGGCCAGAGCCCTGGATGTCATTTGGAAAAACACTAGAG
ACAGACGGCTGGCAGGTGAAGGTTGCTATCCTTAAATACATAGAAACTCTGGCCAAACAGATGGATCCAGGAGATTTTATAAATTCCAGT
GAAACTCGCCTAGCAGTGTCTCGGGTCATCACTTGGACAACAGAACCCAAAAGTTCTGATGTTCGGAAGGCAGCACAGTCAGTGCTGATT
TCATTATTTGAACTCAATACCCCAGAGTTTACAATGTTATTAGGAGCTTTACCAAAAACTTTTCAGGATGGTGCTACCAAGCTTCTTCAT
AATCACCTTCGAAACACTGGCAATGGAACCCAGAGTTCCATGGGGAGTCCTTTGACAAGACCAACACCACGATCACCAGCTAACTGGTCC
AGTCCTCTTACTTCTCCTACCAATACATCACAGAATACTTTATCTCCAAGTGCATTTGATTATGACACAGAAAATATGAACTCTGAAGAT
ATTTATAGCTCTCTTAGAGGTGTCACTGAAGCAATCCAGAATTTCAGCTTCCGTAGCCAAGAAGATATGAATGAGCCATTGAAAAGGGAT
TCTAAAAAAGATGATGGCGATTCAATGTGTGGTGGTCCTGGGATGTCTGACCCAAGAGCAGGAGGTGATGCTACTGACTCAAGTCAAACA
GCTCTTGATAATAAAGCTTCATTGCTCCATTCAATGCCTACTCACTCCTCTCCACGCTCTCGAGACTATAATCCATATAACTATTCAGAT
AGCATCAGTCCCTTCAACAAGTCTGCCCTCAAGGAAGCCATGTTTGATGATGATGCTGACCAGTTTCCTGACGATCTTTCCCTAGATCAT
TCTGACCTAGTTGCAGAGTTGTTGAAGGAGCTGTCTAACCATAATGAGCGTGTAGAAGAAAGAAAAATTGCCCTCTATGAACTTATGAAA
CTGACACAGGAAGAATCTTTTAGTGTTTGGGATGAACACTTCAAAACAATATTGCTTTTATTGCTTGAAACGCTTGGAGATAAAGAGCCT
ACAATCAGGGCTTTGGCATTAAAGGTTTTAAGAGAAATCCTAAGGCATCAACCAGCAAGATTTAAAAACTATGCAGAATTGACTGTCATG
AAAACATTGGAAGCACATAAAGATCCTCATAAGGAGGTGGTGAGATCTGCTGAGGAAGCGGCATCAGTGTTGGCCACTTCAATTAGTCCA
GAGCAGTGCATCAAAGTGCTTTGTCCTATCATTCAAACTGCAGACTACCCAATTAATCTGGCTGCAATCAAAATGCAAACAAAAGTGATA
GAGAGAGTGTCCAAGGAAACCCTAAACCTGCTTTTGCCAGAGATTATGCCAGGTCTAATACAGGGTTATGATAATTCAGAGAGCAGTGTT
CGGAAAGCTTGTGTCTTCTGCCTGGTGGCTGTTCATGCGGTAATTGGTGATGAACTAAAACCACATCTCAGTCAACTTACTGGCAGTAAA
ATGAAGCTACTGAATCTTTACATCAAACGTGCACAAACAGGTTCTGGAGGAGCTGATCCCACTACTGATGTTTCTGGACAAAGTTAGTGA
AGCTCATCACAGCGAACCAGGTCTCTCAAAAGAAAGGACAGATAGACCACCCTCATCAATGAAAGGAAGTTCTCAAACACATCCTTTGGA
ACTTACTATTGTTTCCCAGTTTTAGTTTTTTGTTTCGTTTCGTTTTGTATTTTCTGTAACAGAGGACTATCCTCAGTCTGCATGTAACTT
TTATGATAGTTATTCCAAATTCAAGAAGAAGCAGTATTAACATCAATTGATCGACACAAAGTAATTTTTAATTTAATTCATCATTTCACA
TGTTTGTACTTTGTCTTCCCATTAACCTTTGCCAGTGTTATGATTGTATAAATTTTTTTAAATGCTGGTTAAACAGGAATGCTTAAAGCT
TTAAAAGTTTAACAGTCTAAAACATTTTTGCTTTTATTCAACTGCAGAATAATATTTTTATTGCTACTTTGAGTTTTGTTTCGTATCATG
TCCTATGCTAGAAATATTTAAATGATGTGAAACAAAGCAGGACTAATTTGAACTACAGCTGGACTCCGTTTGTGTGATGGTGATACATGT
CATTAGTTGCAACTTCTTTGGGGTGATCTATAGTTTGAAAACTAAAACCTCAAAGACAGATGTTACAGAATCAGCCAGTTCTGTAAAACT
GATATTGTCTATTGGTTATTGATCTTGCCATCTTTATTTAAAACCATGTCCCTTCTATGATCCCTTAAGAAAGCTGCACCAAATCATCTG
CCTGTTTTTTCTTGATACTTACTGAAATAGAAGGTTTTATTGCAGGGTTTATTTTGGTTTGTTTATATCTTTGTTGTGAATGATGCTTTT
TTGTATTTATTAATATCAAATTCACTTATGAATAAACTTGATAATGGAAACGGACAAAAAAAATCAAGTGCGTGTGTGTCCTTGACCGTC
TTCTGTTTCTCACGTAATAAACAAATTATCGAGACATGGGAGTGACCAGCACCTTTTCTTTAAATGGTGGAACCTGGTTTCCTTTTACCA
TGAAATTGTCTTACTTGAAAATATTGATCCTGATGAGAGAGAAGATGGTGCCAAGGCTGTCTTTGTATAATGGGCTCAAATTCTCTACCT
CTTCAGGGCTAATACTTTTAACTGAGCTGCTGCCTATAGTGTCTTTTGGAAAACTACTTAAAGGGTGATTTTCTGTTACTTTTTAGCAAA
TTTTTTTAATCACCTCTTGCTACACCCATTCTTTTCATGTGCAGCCGACTCAAAAATTACCAGTTTTGGTGAAAGGCTAAATTAGATAAT
TTGGAACCAGGATACTAATGATTTCTCATCTTTACTTTTTTTTAATCCTAATATAAAGTGAATTTGATTGAAAAGGCAAATAGCTATTAG
GGAAGCAGTTTGCCATTGTTGCAGAGTTATCTGTACTTTGTTTAACTGAAAAAAATGTAGAAATATATGTAAAGAATTTAAGACAAGAGT
ACTGAATGGATGATTTGTCATAGGCTTTCCCCTTTCTTTCTGTTCTAGCAGCAGGAAAAGTTTCTCTATATCCTCTCCCTCTACCTGTAA
CAATTTTGTTTTCTACTGTTAATTACATTGTGTATTTATAGTTCTATGCTTACTGTTGTGCATATACTGGCAATAAAACTGTACATAACA
TTACTTGAAAAAGTTAATAATGTATATCAGTTTTTCTGTCTCACTGTGTAACAAGTCACTCAGTTTTATTTTAACTTTAGACGGTCTTGT
ATCAGTGGTGGTCTCTTGAATTTTGTAAGTTCATCTGAGGAGAAAAGATTTTTCAGGTGTAGCTACCACAATCAAAGGTATATAGCTACA
TACGCATGTATATATTACAGCTTATCTGTAAGAAGAAAATGCATTTTAAACACAACTCTTCTCAGTAGCATTTTATGACCTTTGGATATG
TTTGTAATCATTTCGAATCAAAATATTGATTTAATTTTGACCTCTGGTTTAAGATACTGCTTTAACTACTGTTGACAACCAAGTAGAGTG
ACTTAAGCTGAACAGTAACTAACTGGAAAATTAGATAAGCACCTGGCATCTAATGGCAGGCAGGCACTCAAGAAATGAATTAACTACATA
ATGGAAAAGTATGGTTTAATGTGTCCAAATGAAAGCTAGTAGATGTAAACATGGAAAAATTGTGTTTACAATTTTATAATCTCAGTTGAT
AAGACTATAAGAAAGCTGATTATTTAAATCACTATATACAATACACCCTTAATTTGTTCATTCCAGAAACATACTGAGATGTCAGCTACT
TAAAAATGGTCACAAAAAGCTACTGTTTATATTTTTCCTCCTGCTATTCTCTCCCAAATTAATTATTAATAAGTGTTGTTCATTTACTGC

>22976_22976_5_DLC1-CLASP2_DLC1_chr8_13133771_ENST00000512044_CLASP2_chr3_33592887_ENST00000468888_length(amino acids)=516AA_BP=12
MSFGKTLETDGWQVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQ
DGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQED
MNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQF
PDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFK
NYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQG

--------------------------------------------------------------
>22976_22976_6_DLC1-CLASP2_DLC1_chr8_13133771_ENST00000512044_CLASP2_chr3_33592887_ENST00000480013_length(transcript)=3435nt_BP=285nt
AGTTGGCGCTTCCCGGGGCCGCAGTGCCAGCCGCAATGCCGGCCTCCTGAAGGCAGGCGACAGCCTGCGGCCGGGAGCACAGCGCGGGGC
GGAGTACCGAGGCATGGTCGCGGCGCCCGGGCTGCGCTGAAGGCGTCTGCGAGCGGATGGGGGACCCCAAGGCCCACGTGATGGCGCGCC
CCCTGCGAGCCCCTCTCCGGAGGTCCTTTAGCGATCACATCAGGGACTCCACGGCCAGAGCCCTGGATGTCATTTGGAAAAACACTAGAG
ACAGACGGCTGGCAGGTGAAGGTTGCTATCCTTAAATACATAGAAACTCTGGCCAAACAGATGGATCCAGGAGATTTTATAAATTCCAGT
GAAACTCGCCTAGCAGTGTCTCGGGTCATCACTTGGACAACAGAACCCAAAAGTTCTGATGTTCGGAAGGCAGCACAGTCAGTGCTGATT
TCATTATTTGAACTCAATACCCCAGAGTTTACAATGTTATTAGGAGCTTTACCAAAAACTTTTCAGGATGGTGCTACCAAGCTTCTTCAT
AATCACCTTCGAAACACTGGCAATGGAACCCAGAGTTCCATGGGGAGTCCTTTGACAAGACCAACACCACGATCACCAGCTAACTGGTCC
AGTCCTCTTACTTCTCCTACCAATACATCACAGAATACTTTATCTCCAAGTGCATTTGATTATGACACAGAAAATATGAACTCTGAAGAT
ATTTATAGCTCTCTTAGAGGTGTCACTGAAGCAATCCAGAATTTCAGCTTCCGTAGCCAAGAAGATATGAATGAGCCATTGAAAAGGGAT
TCTAAAAAAGATGATGGCGATTCAATGTGTGGTGGTCCTGGGATGTCTGACCCAAGAGCAGGAGGTGATGCTACTGACTCAAGTCAAACA
GCTCTTGATAATAAAGCTTCATTGCTCCATTCAATGCCTACTCACTCCTCTCCACGCTCTCGAGACTATAATCCATATAACTATTCAGAT
AGCATCAGTCCCTTCAACAAGTCTGCCCTCAAGGAAGCCATGTTTGATGATGATGCTGACCAGTTTCCTGACGATCTTTCCCTAGATCAT
TCTGACCTAGTTGCAGAGTTGTTGAAGGAGCTGTCTAACCATAATGAGCGTGTAGAAGAAAGAAAAATTGCCCTCTATGAACTTATGAAA
CTGACACAGGAAGAATCTTTTAGTGTTTGGGATGAACACTTCAAAACAATATTGCTTTTATTGCTTGAAACGCTTGGAGATAAAGAGCCT
ACAATCAGGGCTTTGGCATTAAAGGTTTTAAGAGAAATCCTAAGGCATCAACCAGCAAGATTTAAAAACTATGCAGAATTGACTGTCATG
AAAACATTGGAAGCACATAAAGATCCTCATAAGGAGGTGGTGAGATCTGCTGAGGAAGCGGCATCAGTGTTGGCCACTTCAATTAGTCCA
GAGCAGTGCATCAAAGTGCTTTGTCCTATCATTCAAACTGCAGACTACCCAATTAATCTGGCTGCAATCAAAATGCAAACAAAAGTGATA
GAGAGAGTGTCCAAGGAAACCCTAAACCTGCTTTTGCCAGAGATTATGCCAGGTCTAATACAGGGTTATGATAATTCAGAGAGCAGTGTT
CGGAAAGCTTGTGTCTTCTGCCTGGTGGCTGTTCATGCGGTAATTGGTGATGAACTAAAACCACATCTCAGTCAACTTACTGGCAGTAAA
ATGAAGCTACTGAATCTTTACATCAAACGTGCACAAACAGGTTCTGGAGGAGCTGATCCCACTACTGATGTTTCTGGACAAAGTTAGTGA
AGCTCATCACAGCGAACCAGGTCTCTCAAAAGAAAGGACAGATAGACCACCCTCATCAATGAAAGGAAGTTCTCAAACACATCCTTTGGA
ACTTACTATTGTTTCCCAGTTTTAGTTTTTTGTTTCGTTTCGTTTTGTATTTTCTGTAACAGAGGACTATCCTCAGTCTGCATGTAACTT
TTATGATAGTTATTCCAAATTCAAGAAGAAGCAGTATTAACATCAATTGATCGACACAAAGTAATTTTTAATTTAATTCATCATTTCACA
TGTTTGTACTTTGTCTTCCCATTAACCTTTGCCAGTGTTATGATTGTATAAATTTTTTTAAATGCTGGTTAAACAGGAATGCTTAAAGCT
TTAAAAGTTTAACAGTCTAAAACATTTTTGCTTTTATTCAACTGCAGAATAATATTTTTATTGCTACTTTGAGTTTTGTTTCGTATCATG
TCCTATGCTAGAAATATTTAAATGATGTGAAACAAAGCAGGACTAATTTGAACTACAGCTGGACTCCGTTTGTGTGATGGTGATACATGT
CATTAGTTGCAACTTCTTTGGGGTGATCTATAGTTTGAAAACTAAAACCTCAAAGACAGATGTTACAGAATCAGCCAGTTCTGTAAAACT
GATATTGTCTATTGGTTATTGATCTTGCCATCTTTATTTAAAACCATGTCCCTTCTATGATCCCTTAAGAAAGCTGCACCAAATCATCTG
CCTGTTTTTTCTTGATACTTACTGAAATAGAAGGTTTTATTGCAGGGTTTATTTTGGTTTGTTTATATCTTTGTTGTGAATGATGCTTTT
TTGTATTTATTAATATCAAATTCACTTATGAATAAACTTGATAATGGAAACGGACAAAAAAAATCAAGTGCGTGTGTGTCCTTGACCGTC
TTCTGTTTCTCACGTAATAAACAAATTATCGAGACATGGGAGTGACCAGCACCTTTTCTTTAAATGGTGGAACCTGGTTTCCTTTTACCA
TGAAATTGTCTTACTTGAAAATATTGATCCTGATGAGAGAGAAGATGGTGCCAAGGCTGTCTTTGTATAATGGGCTCAAATTCTCTACCT
CTTCAGGGCTAATACTTTTAACTGAGCTGCTGCCTATAGTGTCTTTTGGAAAACTACTTAAAGGGTGATTTTCTGTTACTTTTTAGCAAA
TTTTTTTAATCACCTCTTGCTACACCCATTCTTTTCATGTGCAGCCGACTCAAAAATTACCAGTTTTGGTGAAAGGCTAAATTAGATAAT
TTGGAACCAGGATACTAATGATTTCTCATCTTTACTTTTTTTTAATCCTAATATAAAGTGAATTTGATTGAAAAGGCAAATAGCTATTAG
GGAAGCAGTTTGCCATTGTTGCAGAGTTATCTGTACTTTGTTTAACTGAAAAAAATGTAGAAATATATGTAAAGAATTTAAGACAAGAGT
ACTGAATGGATGATTTGTCATAGGCTTTCCCCTTTCTTTCTGTTCTAGCAGCAGGAAAAGTTTCTCTATATCCTCTCCCTCTACCTGTAA
CAATTTTGTTTTCTACTGTTAATTACATTGTGTATTTATAGTTCTATGCTTACTGTTGTGCATATACTGGCAATAAAACTGTACATAACA

>22976_22976_6_DLC1-CLASP2_DLC1_chr8_13133771_ENST00000512044_CLASP2_chr3_33592887_ENST00000480013_length(amino acids)=516AA_BP=12
MSFGKTLETDGWQVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQ
DGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQED
MNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQF
PDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFK
NYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQG

--------------------------------------------------------------
>22976_22976_7_DLC1-CLASP2_DLC1_chr8_13133771_ENST00000512044_CLASP2_chr3_33592887_ENST00000539981_length(transcript)=4179nt_BP=285nt
AGTTGGCGCTTCCCGGGGCCGCAGTGCCAGCCGCAATGCCGGCCTCCTGAAGGCAGGCGACAGCCTGCGGCCGGGAGCACAGCGCGGGGC
GGAGTACCGAGGCATGGTCGCGGCGCCCGGGCTGCGCTGAAGGCGTCTGCGAGCGGATGGGGGACCCCAAGGCCCACGTGATGGCGCGCC
CCCTGCGAGCCCCTCTCCGGAGGTCCTTTAGCGATCACATCAGGGACTCCACGGCCAGAGCCCTGGATGTCATTTGGAAAAACACTAGAG
ACAGACGGCTGGCAGGTGAAGGTTGCTATCCTTAAATACATAGAAACTCTGGCCAAACAGATGGATCCAGGAGATTTTATAAATTCCAGT
GAAACTCGCCTAGCAGTGTCTCGGGTCATCACTTGGACAACAGAACCCAAAAGTTCTGATGTTCGGAAGGCAGCACAGTCAGTGCTGATT
TCATTATTTGAACTCAATACCCCAGAGTTTACAATGTTATTAGGAGCTTTACCAAAAACTTTTCAGGATGGTGCTACCAAGCTTCTTCAT
AATCACCTTCGAAACACTGGCAATGGAACCCAGAGTTCCATGGGGAGTCCTTTGACAAGACCAACACCACGATCACCAGCTAACTGGTCC
AGTCCTCTTACTTCTCCTACCAATACATCACAGAATACTTTATCTCCAAGTGCATTTGATTATGACACAGAAAATATGAACTCTGAAGAT
ATTTATAGCTCTCTTAGAGGTGTCACTGAAGCAATCCAGAATTTCAGCTTCCGTAGCCAAGAAGATATGAATGAGCCATTGAAAAGGGAT
TCTAAAAAAGATGATGGCGATTCAATGTGTGGTGGTCCTGGGATGTCTGACCCAAGAGCAGGAGGTGATGCTACTGACTCAAGTCAAACA
GCTCTTGATAATAAAGCTTCATTGCTCCATTCAATGCCTACTCACTCCTCTCCACGCTCTCGAGACTATAATCCATATAACTATTCAGAT
AGCATCAGTCCCTTCAACAAGTCTGCCCTCAAGGAAGCCATGTTTGATGATGATGCTGACCAGTTTCCTGACGATCTTTCCCTAGATCAT
TCTGACCTAGTTGCAGAGTTGTTGAAGGAGCTGTCTAACCATAATGAGCGTGTAGAAGAAAGAAAAATTGCCCTCTATGAACTTATGAAA
CTGACACAGGAAGAATCTTTTAGTGTTTGGGATGAACACTTCAAAACAATATTGCTTTTATTGCTTGAAACGCTTGGAGATAAAGAGCCT
ACAATCAGGGCTTTGGCATTAAAGGTTTTAAGAGAAATCCTAAGGCATCAACCAGCAAGATTTAAAAACTATGCAGAATTGACTGTCATG
AAAACATTGGAAGCACATAAAGATCCTCATAAGGAGGTGGTGAGATCTGCTGAGGAAGCGGCATCAGTGTTGGCCACTTCAATTAGTCCA
GAGCAGTGCATCAAAGTGCTTTGTCCTATCATTCAAACTGCAGACTACCCAATTAATCTGGCTGCAATCAAAATGCAAACAAAAGTGATA
GAGAGAGTGTCCAAGGAAACCCTAAACCTGCTTTTGCCAGAGATTATGCCAGGTCTAATACAGGGTTATGATAATTCAGAGAGCAGTGTT
CGGAAAGCTTGTGTCTTCTGCCTGGTGGCTGTTCATGCGGTAATTGGTGATGAACTAAAACCACATCTCAGTCAACTTACTGGCAGTAAA
ATGAAGCTACTGAATCTTTACATCAAACGTGCACAAACAGGTTCTGGAGGAGCTGATCCCACTACTGATGTTTCTGGACAAAGTTAGTGA
AGCTCATCACAGCGAACCAGGTCTCTCAAAAGAAAGGACAGATAGACCACCCTCATCAATGAAAGGAAGTTCTCAAACACATCCTTTGGA
ACTTACTATTGTTTCCCAGTTTTAGTTTTTTGTTTCGTTTCGTTTTGTATTTTCTGTAACAGAGGACTATCCTCAGTCTGCATGTAACTT
TTATGATAGTTATTCCAAATTCAAGAAGAAGCAGTATTAACATCAATTGATCGACACAAAGTAATTTTTAATTTAATTCATCATTTCACA
TGTTTGTACTTTGTCTTCCCATTAACCTTTGCCAGTGTTATGATTGTATAAATTTTTTTAAATGCTGGTTAAACAGGAATGCTTAAAGCT
TTAAAAGTTTAACAGTCTAAAACATTTTTGCTTTTATTCAACTGCAGAATAATATTTTTATTGCTACTTTGAGTTTTGTTTCGTATCATG
TCCTATGCTAGAAATATTTAAATGATGTGAAACAAAGCAGGACTAATTTGAACTACAGCTGGACTCCGTTTGTGTGATGGTGATACATGT
CATTAGTTGCAACTTCTTTGGGGTGATCTATAGTTTGAAAACTAAAACCTCAAAGACAGATGTTACAGAATCAGCCAGTTCTGTAAAACT
GATATTGTCTATTGGTTATTGATCTTGCCATCTTTATTTAAAACCATGTCCCTTCTATGATCCCTTAAGAAAGCTGCACCAAATCATCTG
CCTGTTTTTTCTTGATACTTACTGAAATAGAAGGTTTTATTGCAGGGTTTATTTTGGTTTGTTTATATCTTTGTTGTGAATGATGCTTTT
TTGTATTTATTAATATCAAATTCACTTATGAATAAACTTGATAATGGAAACGGACAAAAAAAATCAAGTGCGTGTGTGTCCTTGACCGTC
TTCTGTTTCTCACGTAATAAACAAATTATCGAGACATGGGAGTGACCAGCACCTTTTCTTTAAATGGTGGAACCTGGTTTCCTTTTACCA
TGAAATTGTCTTACTTGAAAATATTGATCCTGATGAGAGAGAAGATGGTGCCAAGGCTGTCTTTGTATAATGGGCTCAAATTCTCTACCT
CTTCAGGGCTAATACTTTTAACTGAGCTGCTGCCTATAGTGTCTTTTGGAAAACTACTTAAAGGGTGATTTTCTGTTACTTTTTAGCAAA
TTTTTTTAATCACCTCTTGCTACACCCATTCTTTTCATGTGCAGCCGACTCAAAAATTACCAGTTTTGGTGAAAGGCTAAATTAGATAAT
TTGGAACCAGGATACTAATGATTTCTCATCTTTACTTTTTTTTAATCCTAATATAAAGTGAATTTGATTGAAAAGGCAAATAGCTATTAG
GGAAGCAGTTTGCCATTGTTGCAGAGTTATCTGTACTTTGTTTAACTGAAAAAAATGTAGAAATATATGTAAAGAATTTAAGACAAGAGT
ACTGAATGGATGATTTGTCATAGGCTTTCCCCTTTCTTTCTGTTCTAGCAGCAGGAAAAGTTTCTCTATATCCTCTCCCTCTACCTGTAA
CAATTTTGTTTTCTACTGTTAATTACATTGTGTATTTATAGTTCTATGCTTACTGTTGTGCATATACTGGCAATAAAACTGTACATAACA
TTACTTGAAAAAGTTAATAATGTATATCAGTTTTTCTGTCTCACTGTGTAACAAGTCACTCAGTTTTATTTTAACTTTAGACGGTCTTGT
ATCAGTGGTGGTCTCTTGAATTTTGTAAGTTCATCTGAGGAGAAAAGATTTTTCAGGTGTAGCTACCACAATCAAAGGTATATAGCTACA
TACGCATGTATATATTACAGCTTATCTGTAAGAAGAAAATGCATTTTAAACACAACTCTTCTCAGTAGCATTTTATGACCTTTGGATATG
TTTGTAATCATTTCGAATCAAAATATTGATTTAATTTTGACCTCTGGTTTAAGATACTGCTTTAACTACTGTTGACAACCAAGTAGAGTG
ACTTAAGCTGAACAGTAACTAACTGGAAAATTAGATAAGCACCTGGCATCTAATGGCAGGCAGGCACTCAAGAAATGAATTAACTACATA
ATGGAAAAGTATGGTTTAATGTGTCCAAATGAAAGCTAGTAGATGTAAACATGGAAAAATTGTGTTTACAATTTTATAATCTCAGTTGAT
AAGACTATAAGAAAGCTGATTATTTAAATCACTATATACAATACACCCTTAATTTGTTCATTCCAGAAACATACTGAGATGTCAGCTACT
TAAAAATGGTCACAAAAAGCTACTGTTTATATTTTTCCTCCTGCTATTCTCTCCCAAATTAATTATTAATAAGTGTTGTTCATTTACTGC

>22976_22976_7_DLC1-CLASP2_DLC1_chr8_13133771_ENST00000512044_CLASP2_chr3_33592887_ENST00000539981_length(amino acids)=516AA_BP=12
MSFGKTLETDGWQVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQ
DGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQED
MNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQF
PDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFK
NYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQG

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Fusion Gene PPI Analysis for DLC1-CLASP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCLASP2chr8:13133771chr3:33592887ENST00000313350013444_5800432.0microtubules%2C MAPRE1 and MAPRE3
TgeneCLASP2chr8:13133771chr3:33592887ENST00000313350013872_12940432.0RSN and localization to the Golgi and kinetochores


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DLC1-CLASP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DLC1-CLASP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource