FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:DLG1-WDR53 (FusionGDB2 ID:23052)

Fusion Gene Summary for DLG1-WDR53

check button Fusion gene summary
Fusion gene informationFusion gene name: DLG1-WDR53
Fusion gene ID: 23052
HgeneTgene
Gene symbol

DLG1

WDR53

Gene ID

1739

348793

Gene namediscs large MAGUK scaffold protein 1WD repeat domain 53
SynonymsDLGH1|SAP-97|SAP97|hdlg-
Cytomap

3q29

3q29

Type of geneprotein-codingprotein-coding
Descriptiondisks large homolog 1dJ1061C18.1.1discs large homolog 1, scribble cell polarity complex componentpresynaptic protein SAP97synapse-associated protein 97WD repeat-containing protein 53WD domain, G-beta repeat-containing protein
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000314062, ENST00000346964, 
ENST00000357674, ENST00000392382, 
ENST00000419354, ENST00000422288, 
ENST00000448528, ENST00000450955, 
ENST00000485409, ENST00000443183, 
ENST00000452595, 		ENST00000332629, 
ENST00000429115, ENST00000433160, 
Fusion gene scores* DoF score27 X 18 X 14=68045 X 5 X 3=75
# samples 408
** MAII scorelog2(40/6804*10)=-4.08831123588866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/75*10)=0.0931094043914815
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DLG1 [Title/Abstract] AND WDR53 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDLG1(197009549)-WDR53(196288362), # samples:1
DLG1(197009550)-WDR53(196288362), # samples:1
DLG1(197009550)-WDR53(196281678), # samples:1
DLG1(197009549)-WDR53(196288361), # samples:1
DLG1(197009549)-WDR53(196281677), # samples:1
Anticipated loss of major functional domain due to fusion event.DLG1-WDR53 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DLG1-WDR53 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
DLG1-WDR53 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDLG1

GO:0001935

endothelial cell proliferation

14699157

HgeneDLG1

GO:0007015

actin filament organization

14699157

HgeneDLG1

GO:0030866

cortical actin cytoskeleton organization

14699157

HgeneDLG1

GO:0042391

regulation of membrane potential

12970345

HgeneDLG1

GO:0043268

positive regulation of potassium ion transport

12970345

HgeneDLG1

GO:0070830

bicellular tight junction assembly

17332497

HgeneDLG1

GO:0098609

cell-cell adhesion

14699157

HgeneDLG1

GO:1902473

regulation of protein localization to synapse

23676497

HgeneDLG1

GO:1903078

positive regulation of protein localization to plasma membrane

12970345


check buttonFusion gene breakpoints across DLG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across WDR53 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-51-6867-01ADLG1chr3

197009549

-WDR53chr3

196281677

-
ChimerDB4LUSCTCGA-51-6867-01ADLG1chr3

197009549

-WDR53chr3

196288361

-
ChimerDB4LUSCTCGA-51-6867DLG1chr3

197009549

-WDR53chr3

196288362

-
ChimerDB4LUSCTCGA-51-6867DLG1chr3

197009550

-WDR53chr3

196281678

-
ChimerDB4LUSCTCGA-51-6867DLG1chr3

197009550

-WDR53chr3

196288362

-


Top

Fusion Gene ORF analysis for DLG1-WDR53

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000314062ENST00000332629DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-5UTRENST00000314062ENST00000332629DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-5UTRENST00000314062ENST00000332629DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-5UTRENST00000314062ENST00000429115DLG1chr3

197009549

-WDR53chr3

196281677

-
5CDS-5UTRENST00000314062ENST00000429115DLG1chr3

197009550

-WDR53chr3

196281678

-
5CDS-5UTRENST00000314062ENST00000433160DLG1chr3

197009549

-WDR53chr3

196281677

-
5CDS-5UTRENST00000314062ENST00000433160DLG1chr3

197009550

-WDR53chr3

196281678

-
5CDS-5UTRENST00000346964ENST00000332629DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-5UTRENST00000346964ENST00000332629DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-5UTRENST00000346964ENST00000332629DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-5UTRENST00000346964ENST00000429115DLG1chr3

197009549

-WDR53chr3

196281677

-
5CDS-5UTRENST00000346964ENST00000429115DLG1chr3

197009550

-WDR53chr3

196281678

-
5CDS-5UTRENST00000346964ENST00000433160DLG1chr3

197009549

-WDR53chr3

196281677

-
5CDS-5UTRENST00000346964ENST00000433160DLG1chr3

197009550

-WDR53chr3

196281678

-
5CDS-5UTRENST00000357674ENST00000332629DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-5UTRENST00000357674ENST00000332629DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-5UTRENST00000357674ENST00000332629DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-5UTRENST00000357674ENST00000429115DLG1chr3

197009549

-WDR53chr3

196281677

-
5CDS-5UTRENST00000357674ENST00000429115DLG1chr3

197009550

-WDR53chr3

196281678

-
5CDS-5UTRENST00000357674ENST00000433160DLG1chr3

197009549

-WDR53chr3

196281677

-
5CDS-5UTRENST00000357674ENST00000433160DLG1chr3

197009550

-WDR53chr3

196281678

-
5CDS-5UTRENST00000392382ENST00000332629DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-5UTRENST00000392382ENST00000332629DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-5UTRENST00000392382ENST00000332629DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-5UTRENST00000392382ENST00000429115DLG1chr3

197009549

-WDR53chr3

196281677

-
5CDS-5UTRENST00000392382ENST00000429115DLG1chr3

197009550

-WDR53chr3

196281678

-
5CDS-5UTRENST00000392382ENST00000433160DLG1chr3

197009549

-WDR53chr3

196281677

-
5CDS-5UTRENST00000392382ENST00000433160DLG1chr3

197009550

-WDR53chr3

196281678

-
5CDS-5UTRENST00000419354ENST00000332629DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-5UTRENST00000419354ENST00000332629DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-5UTRENST00000419354ENST00000332629DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-5UTRENST00000419354ENST00000429115DLG1chr3

197009549

-WDR53chr3

196281677

-
5CDS-5UTRENST00000419354ENST00000429115DLG1chr3

197009550

-WDR53chr3

196281678

-
5CDS-5UTRENST00000419354ENST00000433160DLG1chr3

197009549

-WDR53chr3

196281677

-
5CDS-5UTRENST00000419354ENST00000433160DLG1chr3

197009550

-WDR53chr3

196281678

-
5CDS-5UTRENST00000422288ENST00000332629DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-5UTRENST00000422288ENST00000332629DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-5UTRENST00000422288ENST00000332629DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-5UTRENST00000422288ENST00000429115DLG1chr3

197009549

-WDR53chr3

196281677

-
5CDS-5UTRENST00000422288ENST00000429115DLG1chr3

197009550

-WDR53chr3

196281678

-
5CDS-5UTRENST00000422288ENST00000433160DLG1chr3

197009549

-WDR53chr3

196281677

-
5CDS-5UTRENST00000422288ENST00000433160DLG1chr3

197009550

-WDR53chr3

196281678

-
5CDS-5UTRENST00000448528ENST00000332629DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-5UTRENST00000448528ENST00000332629DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-5UTRENST00000448528ENST00000332629DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-5UTRENST00000448528ENST00000429115DLG1chr3

197009549

-WDR53chr3

196281677

-
5CDS-5UTRENST00000448528ENST00000429115DLG1chr3

197009550

-WDR53chr3

196281678

-
5CDS-5UTRENST00000448528ENST00000433160DLG1chr3

197009549

-WDR53chr3

196281677

-
5CDS-5UTRENST00000448528ENST00000433160DLG1chr3

197009550

-WDR53chr3

196281678

-
5CDS-5UTRENST00000450955ENST00000332629DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-5UTRENST00000450955ENST00000332629DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-5UTRENST00000450955ENST00000332629DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-5UTRENST00000450955ENST00000429115DLG1chr3

197009549

-WDR53chr3

196281677

-
5CDS-5UTRENST00000450955ENST00000429115DLG1chr3

197009550

-WDR53chr3

196281678

-
5CDS-5UTRENST00000450955ENST00000433160DLG1chr3

197009549

-WDR53chr3

196281677

-
5CDS-5UTRENST00000450955ENST00000433160DLG1chr3

197009550

-WDR53chr3

196281678

-
5CDS-intronENST00000314062ENST00000429115DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-intronENST00000314062ENST00000429115DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-intronENST00000314062ENST00000429115DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-intronENST00000314062ENST00000433160DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-intronENST00000314062ENST00000433160DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-intronENST00000314062ENST00000433160DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-intronENST00000346964ENST00000429115DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-intronENST00000346964ENST00000429115DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-intronENST00000346964ENST00000429115DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-intronENST00000346964ENST00000433160DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-intronENST00000346964ENST00000433160DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-intronENST00000346964ENST00000433160DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-intronENST00000357674ENST00000429115DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-intronENST00000357674ENST00000429115DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-intronENST00000357674ENST00000429115DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-intronENST00000357674ENST00000433160DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-intronENST00000357674ENST00000433160DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-intronENST00000357674ENST00000433160DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-intronENST00000392382ENST00000429115DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-intronENST00000392382ENST00000429115DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-intronENST00000392382ENST00000429115DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-intronENST00000392382ENST00000433160DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-intronENST00000392382ENST00000433160DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-intronENST00000392382ENST00000433160DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-intronENST00000419354ENST00000429115DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-intronENST00000419354ENST00000429115DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-intronENST00000419354ENST00000429115DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-intronENST00000419354ENST00000433160DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-intronENST00000419354ENST00000433160DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-intronENST00000419354ENST00000433160DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-intronENST00000422288ENST00000429115DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-intronENST00000422288ENST00000429115DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-intronENST00000422288ENST00000429115DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-intronENST00000422288ENST00000433160DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-intronENST00000422288ENST00000433160DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-intronENST00000422288ENST00000433160DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-intronENST00000448528ENST00000429115DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-intronENST00000448528ENST00000429115DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-intronENST00000448528ENST00000429115DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-intronENST00000448528ENST00000433160DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-intronENST00000448528ENST00000433160DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-intronENST00000448528ENST00000433160DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-intronENST00000450955ENST00000429115DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-intronENST00000450955ENST00000429115DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-intronENST00000450955ENST00000429115DLG1chr3

197009550

-WDR53chr3

196288362

-
5CDS-intronENST00000450955ENST00000433160DLG1chr3

197009549

-WDR53chr3

196288361

-
5CDS-intronENST00000450955ENST00000433160DLG1chr3

197009549

-WDR53chr3

196288362

-
5CDS-intronENST00000450955ENST00000433160DLG1chr3

197009550

-WDR53chr3

196288362

-
5UTR-3CDSENST00000485409ENST00000332629DLG1chr3

197009549

-WDR53chr3

196281677

-
5UTR-3CDSENST00000485409ENST00000332629DLG1chr3

197009550

-WDR53chr3

196281678

-
5UTR-5UTRENST00000485409ENST00000332629DLG1chr3

197009549

-WDR53chr3

196288361

-
5UTR-5UTRENST00000485409ENST00000332629DLG1chr3

197009549

-WDR53chr3

196288362

-
5UTR-5UTRENST00000485409ENST00000332629DLG1chr3

197009550

-WDR53chr3

196288362

-
5UTR-5UTRENST00000485409ENST00000429115DLG1chr3

197009549

-WDR53chr3

196281677

-
5UTR-5UTRENST00000485409ENST00000429115DLG1chr3

197009550

-WDR53chr3

196281678

-
5UTR-5UTRENST00000485409ENST00000433160DLG1chr3

197009549

-WDR53chr3

196281677

-
5UTR-5UTRENST00000485409ENST00000433160DLG1chr3

197009550

-WDR53chr3

196281678

-
5UTR-intronENST00000485409ENST00000429115DLG1chr3

197009549

-WDR53chr3

196288361

-
5UTR-intronENST00000485409ENST00000429115DLG1chr3

197009549

-WDR53chr3

196288362

-
5UTR-intronENST00000485409ENST00000429115DLG1chr3

197009550

-WDR53chr3

196288362

-
5UTR-intronENST00000485409ENST00000433160DLG1chr3

197009549

-WDR53chr3

196288361

-
5UTR-intronENST00000485409ENST00000433160DLG1chr3

197009549

-WDR53chr3

196288362

-
5UTR-intronENST00000485409ENST00000433160DLG1chr3

197009550

-WDR53chr3

196288362

-
Frame-shiftENST00000314062ENST00000332629DLG1chr3

197009549

-WDR53chr3

196281677

-
Frame-shiftENST00000314062ENST00000332629DLG1chr3

197009550

-WDR53chr3

196281678

-
Frame-shiftENST00000346964ENST00000332629DLG1chr3

197009549

-WDR53chr3

196281677

-
Frame-shiftENST00000346964ENST00000332629DLG1chr3

197009550

-WDR53chr3

196281678

-
Frame-shiftENST00000357674ENST00000332629DLG1chr3

197009549

-WDR53chr3

196281677

-
Frame-shiftENST00000357674ENST00000332629DLG1chr3

197009550

-WDR53chr3

196281678

-
Frame-shiftENST00000392382ENST00000332629DLG1chr3

197009549

-WDR53chr3

196281677

-
Frame-shiftENST00000392382ENST00000332629DLG1chr3

197009550

-WDR53chr3

196281678

-
Frame-shiftENST00000419354ENST00000332629DLG1chr3

197009549

-WDR53chr3

196281677

-
Frame-shiftENST00000419354ENST00000332629DLG1chr3

197009550

-WDR53chr3

196281678

-
Frame-shiftENST00000422288ENST00000332629DLG1chr3

197009549

-WDR53chr3

196281677

-
Frame-shiftENST00000422288ENST00000332629DLG1chr3

197009550

-WDR53chr3

196281678

-
Frame-shiftENST00000448528ENST00000332629DLG1chr3

197009549

-WDR53chr3

196281677

-
Frame-shiftENST00000448528ENST00000332629DLG1chr3

197009550

-WDR53chr3

196281678

-
Frame-shiftENST00000450955ENST00000332629DLG1chr3

197009549

-WDR53chr3

196281677

-
Frame-shiftENST00000450955ENST00000332629DLG1chr3

197009550

-WDR53chr3

196281678

-
intron-3CDSENST00000443183ENST00000332629DLG1chr3

197009549

-WDR53chr3

196281677

-
intron-3CDSENST00000443183ENST00000332629DLG1chr3

197009550

-WDR53chr3

196281678

-
intron-3CDSENST00000452595ENST00000332629DLG1chr3

197009549

-WDR53chr3

196281677

-
intron-3CDSENST00000452595ENST00000332629DLG1chr3

197009550

-WDR53chr3

196281678

-
intron-5UTRENST00000443183ENST00000332629DLG1chr3

197009549

-WDR53chr3

196288361

-
intron-5UTRENST00000443183ENST00000332629DLG1chr3

197009549

-WDR53chr3

196288362

-
intron-5UTRENST00000443183ENST00000332629DLG1chr3

197009550

-WDR53chr3

196288362

-
intron-5UTRENST00000443183ENST00000429115DLG1chr3

197009549

-WDR53chr3

196281677

-
intron-5UTRENST00000443183ENST00000429115DLG1chr3

197009550

-WDR53chr3

196281678

-
intron-5UTRENST00000443183ENST00000433160DLG1chr3

197009549

-WDR53chr3

196281677

-
intron-5UTRENST00000443183ENST00000433160DLG1chr3

197009550

-WDR53chr3

196281678

-
intron-5UTRENST00000452595ENST00000332629DLG1chr3

197009549

-WDR53chr3

196288361

-
intron-5UTRENST00000452595ENST00000332629DLG1chr3

197009549

-WDR53chr3

196288362

-
intron-5UTRENST00000452595ENST00000332629DLG1chr3

197009550

-WDR53chr3

196288362

-
intron-5UTRENST00000452595ENST00000429115DLG1chr3

197009549

-WDR53chr3

196281677

-
intron-5UTRENST00000452595ENST00000429115DLG1chr3

197009550

-WDR53chr3

196281678

-
intron-5UTRENST00000452595ENST00000433160DLG1chr3

197009549

-WDR53chr3

196281677

-
intron-5UTRENST00000452595ENST00000433160DLG1chr3

197009550

-WDR53chr3

196281678

-
intron-intronENST00000443183ENST00000429115DLG1chr3

197009549

-WDR53chr3

196288361

-
intron-intronENST00000443183ENST00000429115DLG1chr3

197009549

-WDR53chr3

196288362

-
intron-intronENST00000443183ENST00000429115DLG1chr3

197009550

-WDR53chr3

196288362

-
intron-intronENST00000443183ENST00000433160DLG1chr3

197009549

-WDR53chr3

196288361

-
intron-intronENST00000443183ENST00000433160DLG1chr3

197009549

-WDR53chr3

196288362

-
intron-intronENST00000443183ENST00000433160DLG1chr3

197009550

-WDR53chr3

196288362

-
intron-intronENST00000452595ENST00000429115DLG1chr3

197009549

-WDR53chr3

196288361

-
intron-intronENST00000452595ENST00000429115DLG1chr3

197009549

-WDR53chr3

196288362

-
intron-intronENST00000452595ENST00000429115DLG1chr3

197009550

-WDR53chr3

196288362

-
intron-intronENST00000452595ENST00000433160DLG1chr3

197009549

-WDR53chr3

196288361

-
intron-intronENST00000452595ENST00000433160DLG1chr3

197009549

-WDR53chr3

196288362

-
intron-intronENST00000452595ENST00000433160DLG1chr3

197009550

-WDR53chr3

196288362

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for DLG1-WDR53


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for DLG1-WDR53


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:197009549/:196288362)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for DLG1-WDR53


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for DLG1-WDR53


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DLG1-WDR53


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for DLG1-WDR53


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource