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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DLG2-CARD17 (FusionGDB2 ID:23059)

Fusion Gene Summary for DLG2-CARD17

check button Fusion gene summary
Fusion gene informationFusion gene name: DLG2-CARD17
Fusion gene ID: 23059
HgeneTgene
Gene symbol

DLG2

CARD17

Gene ID

4355

440068

Gene namemembrane palmitoylated protein 2caspase recruitment domain family member 17
SynonymsDLG2INCA
Cytomap

17q21.31

11q22.3

Type of geneprotein-codingprotein-coding
DescriptionMAGUK p55 subfamily member 2discs large, homolog 2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)caspase recruitment domain-containing protein 17Inhibitory CARDcaspase-1 inhibitor INCAinhibitory caspase recruitment domain (CARD) proteininhibitory caspase recruitment domain protein
Modification date2020031320200320
UniProtAcc.

Q5XLA6

Ensembl transtripts involved in fusion geneENST00000376104, ENST00000376106, 
ENST00000398304, ENST00000404783, 
ENST00000426717, ENST00000537455, 
ENST00000280241, ENST00000330014, 
ENST00000398309, ENST00000418306, 
ENST00000524982, ENST00000530800, 
ENST00000531015, ENST00000532653, 
ENST00000543673, ENST00000398301, 
ENST00000472545, 		ENST00000375707, 
Fusion gene scores* DoF score22 X 25 X 7=38503 X 1 X 2=6
# samples 233
** MAII scorelog2(23/3850*10)=-4.06515267952525
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/6*10)=2.32192809488736
Context

PubMed: DLG2 [Title/Abstract] AND CARD17 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDLG2(83252725)-CARD17(104970148), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCARD17

GO:0050713

negative regulation of interleukin-1 beta secretion

15383541

TgeneCARD17

GO:0071222

cellular response to lipopolysaccharide

15383541


check buttonFusion gene breakpoints across DLG2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CARD17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-YL-A8S8-01ADLG2chr11

83252725

-CARD17chr11

104970148

-
ChimerDB4PRADTCGA-YL-A8S8DLG2chr11

83252725

-CARD17chr11

104970148

-


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Fusion Gene ORF analysis for DLG2-CARD17

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000376104ENST00000375707DLG2chr11

83252725

-CARD17chr11

104970148

-
Frame-shiftENST00000376106ENST00000375707DLG2chr11

83252725

-CARD17chr11

104970148

-
Frame-shiftENST00000398304ENST00000375707DLG2chr11

83252725

-CARD17chr11

104970148

-
Frame-shiftENST00000404783ENST00000375707DLG2chr11

83252725

-CARD17chr11

104970148

-
Frame-shiftENST00000426717ENST00000375707DLG2chr11

83252725

-CARD17chr11

104970148

-
Frame-shiftENST00000537455ENST00000375707DLG2chr11

83252725

-CARD17chr11

104970148

-
In-frameENST00000280241ENST00000375707DLG2chr11

83252725

-CARD17chr11

104970148

-
In-frameENST00000330014ENST00000375707DLG2chr11

83252725

-CARD17chr11

104970148

-
In-frameENST00000398309ENST00000375707DLG2chr11

83252725

-CARD17chr11

104970148

-
In-frameENST00000418306ENST00000375707DLG2chr11

83252725

-CARD17chr11

104970148

-
In-frameENST00000524982ENST00000375707DLG2chr11

83252725

-CARD17chr11

104970148

-
In-frameENST00000530800ENST00000375707DLG2chr11

83252725

-CARD17chr11

104970148

-
In-frameENST00000531015ENST00000375707DLG2chr11

83252725

-CARD17chr11

104970148

-
In-frameENST00000532653ENST00000375707DLG2chr11

83252725

-CARD17chr11

104970148

-
In-frameENST00000543673ENST00000375707DLG2chr11

83252725

-CARD17chr11

104970148

-
intron-3CDSENST00000398301ENST00000375707DLG2chr11

83252725

-CARD17chr11

104970148

-
intron-3CDSENST00000472545ENST00000375707DLG2chr11

83252725

-CARD17chr11

104970148

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398309DLG2chr1183252725-ENST00000375707CARD17chr11104970148-244822734712348625
ENST00000418306DLG2chr1183252725-ENST00000375707CARD17chr11104970148-16931518251593522
ENST00000280241DLG2chr1183252725-ENST00000375707CARD17chr11104970148-2094191901994664
ENST00000543673DLG2chr1183252725-ENST00000375707CARD17chr11104970148-2292211702192730
ENST00000330014DLG2chr1183252725-ENST00000375707CARD17chr11104970148-18111636171711564
ENST00000524982DLG2chr1183252725-ENST00000375707CARD17chr11104970148-20391864621939625
ENST00000532653DLG2chr1183252725-ENST00000375707CARD17chr11104970148-228021053032180625
ENST00000531015DLG2chr1183252725-ENST00000375707CARD17chr11104970148-19031728251803592
ENST00000530800DLG2chr1183252725-ENST00000375707CARD17chr11104970148-56839355468137

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398309ENST00000375707DLG2chr1183252725-CARD17chr11104970148-0.0018314840.99816847
ENST00000418306ENST00000375707DLG2chr1183252725-CARD17chr11104970148-0.0019688150.9980312
ENST00000280241ENST00000375707DLG2chr1183252725-CARD17chr11104970148-0.0052597910.9947402
ENST00000543673ENST00000375707DLG2chr1183252725-CARD17chr11104970148-0.0062938050.99370617
ENST00000330014ENST00000375707DLG2chr1183252725-CARD17chr11104970148-0.0013351110.99866486
ENST00000524982ENST00000375707DLG2chr1183252725-CARD17chr11104970148-0.0024359620.9975641
ENST00000532653ENST00000375707DLG2chr1183252725-CARD17chr11104970148-0.0025034560.99749655
ENST00000531015ENST00000375707DLG2chr1183252725-CARD17chr11104970148-0.0015557260.99844426
ENST00000530800ENST00000375707DLG2chr1183252725-CARD17chr11104970148-0.0231461080.9768539

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Fusion Genomic Features for DLG2-CARD17


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DLG2-CARD17


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:83252725/chr11:104970148)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CARD17

Q5XLA6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation. {ECO:0000269|PubMed:15383541}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDLG2chr11:83252725chr11:104970148ENST00000280241-1422193_279639910.0DomainPDZ 2
HgeneDLG2chr11:83252725chr11:104970148ENST00000280241-1422421_501639910.0DomainPDZ 3
HgeneDLG2chr11:83252725chr11:104970148ENST00000280241-1422536_606639910.0DomainSH3
HgeneDLG2chr11:83252725chr11:104970148ENST00000280241-142298_184639910.0DomainPDZ 1
HgeneDLG2chr11:83252725chr11:104970148ENST00000376104-2028193_279705976.0DomainPDZ 2
HgeneDLG2chr11:83252725chr11:104970148ENST00000376104-2028421_501705976.0DomainPDZ 3
HgeneDLG2chr11:83252725chr11:104970148ENST00000376104-2028536_606705976.0DomainSH3
HgeneDLG2chr11:83252725chr11:104970148ENST00000376104-202898_184705976.0DomainPDZ 1
HgeneDLG2chr11:83252725chr11:104970148ENST00000398309-1523193_279600871.0DomainPDZ 2
HgeneDLG2chr11:83252725chr11:104970148ENST00000398309-1523421_501600871.0DomainPDZ 3
HgeneDLG2chr11:83252725chr11:104970148ENST00000398309-152398_184600871.0DomainPDZ 1
HgeneDLG2chr11:83252725chr11:104970148ENST00000418306-1220193_279497750.0DomainPDZ 2
HgeneDLG2chr11:83252725chr11:104970148ENST00000418306-122098_184497750.0DomainPDZ 1
HgeneDLG2chr11:83252725chr11:104970148ENST00000543673-1826193_279705976.0DomainPDZ 2
HgeneDLG2chr11:83252725chr11:104970148ENST00000543673-1826421_501705976.0DomainPDZ 3
HgeneDLG2chr11:83252725chr11:104970148ENST00000543673-1826536_606705976.0DomainSH3
HgeneDLG2chr11:83252725chr11:104970148ENST00000543673-182698_184705976.0DomainPDZ 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDLG2chr11:83252725chr11:104970148ENST00000280241-1422680_855639910.0DomainGuanylate kinase-like
HgeneDLG2chr11:83252725chr11:104970148ENST00000376104-2028680_855705976.0DomainGuanylate kinase-like
HgeneDLG2chr11:83252725chr11:104970148ENST00000376106-1422193_27982335.0DomainPDZ 2
HgeneDLG2chr11:83252725chr11:104970148ENST00000376106-1422421_50182335.0DomainPDZ 3
HgeneDLG2chr11:83252725chr11:104970148ENST00000376106-1422536_60682335.0DomainSH3
HgeneDLG2chr11:83252725chr11:104970148ENST00000376106-1422680_85582335.0DomainGuanylate kinase-like
HgeneDLG2chr11:83252725chr11:104970148ENST00000376106-142298_18482335.0DomainPDZ 1
HgeneDLG2chr11:83252725chr11:104970148ENST00000398309-1523536_606600871.0DomainSH3
HgeneDLG2chr11:83252725chr11:104970148ENST00000398309-1523680_855600871.0DomainGuanylate kinase-like
HgeneDLG2chr11:83252725chr11:104970148ENST00000418306-1220421_501497750.0DomainPDZ 3
HgeneDLG2chr11:83252725chr11:104970148ENST00000418306-1220536_606497750.0DomainSH3
HgeneDLG2chr11:83252725chr11:104970148ENST00000418306-1220680_855497750.0DomainGuanylate kinase-like
HgeneDLG2chr11:83252725chr11:104970148ENST00000426717-311193_27982335.0DomainPDZ 2
HgeneDLG2chr11:83252725chr11:104970148ENST00000426717-311421_50182335.0DomainPDZ 3
HgeneDLG2chr11:83252725chr11:104970148ENST00000426717-311536_60682335.0DomainSH3
HgeneDLG2chr11:83252725chr11:104970148ENST00000426717-311680_85582335.0DomainGuanylate kinase-like
HgeneDLG2chr11:83252725chr11:104970148ENST00000426717-31198_18482335.0DomainPDZ 1
HgeneDLG2chr11:83252725chr11:104970148ENST00000543673-1826680_855705976.0DomainGuanylate kinase-like
TgeneCARD17chr11:83252725chr11:104970148ENST00000375707141_919172.33333333333333DomainCARD


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Fusion Gene Sequence for DLG2-CARD17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>23059_23059_1_DLG2-CARD17_DLG2_chr11_83252725_ENST00000280241_CARD17_chr11_104970148_ENST00000375707_length(transcript)=2094nt_BP=1919nt
ATGAATGCATACCTCACCAAGCAACACAGCTGCAGCCGGGGGTCCGATGGGATGGATGCCGTCAGGAGTGCGCCCACCCTGATCAGGGAT
GCCCACTGTGCTTGTGGCTGGCAGAGGAACTGTCAGGGGCTCGGGTACAGTTCTCAGACCATGCCCTCCTCAGGACCAGGGGGCCCAGCT
TCAAACAGGACCGGGGGGTCCAGCTTCAACAGGACCTTGTGGGACAGTGTGCGGAAAAGCCCCCACAAGACGAGCACCAAGGGCAAAGGG
ACTTGTGGGGAGCATTGTACCTGCCCACATGGTTGGTTCAGCCCAGCACAGGCCAGTCCTGCTCCTATAATTGTCAACACAGATACTTTG
GACACAATTCCTTATGTCAATGGGACAGAAATTGAATATGAATTTGAAGAAATTACACTGGAGAGGGGGAATTCTGGCCTGGGATTCAGT
ATTGCTGGGGGGACAGATAATCCCCACATTGGAGATGACCCTGGCATATTTATTACGAAGATTATACCAGGAGGTGCTGCAGCAGAGGAT
GGCAGACTCAGGGTCAATGATTGTATCTTGCGGGTGAATGAGGTTGATGTGTCAGAGGTTTCCCACAGTAAAGCGGTGGAAGCCCTGAAG
GAAGCAGGGTCTATCGTTCGGCTGTATGTGCGTAGAAGACGACCTATTTTGGAGACCGTTGTGGAAATCAAACTGTTCAAAGGCCCTAAA
GGTTTAGGCTTCAGTATTGCAGGAGGTGTGGGGAACCAACACATTCCTGGAGACAACAGCATTTATGTAACTAAAATTATAGATGGAGGA
GCTGCACAAAAAGATGGAAGGTTGCAAGTAGGAGATAGACTACTAATGGTAAACAACTACAGTTTAGAAGAAGTAACACACGAAGAGGCA
GTAGCAATATTAAAGAACACATCAGAGGTAGTTTATTTAAAAGTTGGCAAACCCACTACCATTTATATGACTGATCCTTATGGTCCACCT
GATATTACTCACTCTTATTCTCCACCAATGGAAAACCATCTACTCTCTGGCAACAATGGCACTTTAGAATATAAAACCTCCCTGCCACCC
ATCTCTCCAGGAAGGTACTCACCAATTCCAAAGCACATGCTTGTTGACGACGACTACACCAGGCCTCCGGAACCTGTTTACAGCACTGTG
AACAAACTATGTGATAAGCCTGCTTCTCCCAGGCACTATTCCCCTGTTGAGTGTGACAAAAGCTTCCTCCTCTCAGCTCCCTATTCCCAC
TACCACCTAGGCCTGCTACCTGACTCTGAGATGACCAGTCATTCCCAACATAGCACCGCAACTCGTCAGCCTTCAATGACTCTCCAACGG
GCCGTCTCCCTGGAAGGAGAGCCTCGCAAGGTAGTCCTGCACAAAGGCTCCACTGGCCTGGGCTTCAACATTGTCGGTGGGGAAGATGGA
GAAGGTATTTTTGTGTCCTTCATTCTGGCTGGTGGACCAGCAGACCTAAGTGGGGAGCTCCAGAGAGGAGACCAGATCCTATCGGTGAAT
GGCATTGACCTCCGTGGTGCATCCCACGAGCAGGCAGCTGCTGCACTAAAGGGGGCTGGACAGACAGTGACGATTATAGCACAATATCAA
CCTGAAGATTACGCTCGATTTGAGGCCAAAATCCATGACCTACGAGAGCAGATGATGAACCACAGCATGAGCTCCGGGTCCGGATCCCTG
CGAACCAATCAGAAACGCTCCCTCTACGTCAGAGCCATGTTCGACTACGACAAGAGCAAGGACAGTGGGCTGCCAAGTCAAGGACTTAGT
TTTAAATATGGAGATATTCTCCACGTTATCAATGCCTCTGATGATGAGTGGTGGCAAGCCAGGAGAGTCATGCTGGAGGGAGACAGTGAG
GAGATGGGGGTCATCCCCAGCAAAAGGAGGTCCAACATCTGGAAATCACCTTACTACACAAGATTCTCAAATAGTACTTCCTTCCTAGGT
TCAACTTTCATTTGAGCAGCCAGATGATAAAGCACAGATGCCCAGCACTGAAAGAGTTACTTCGACAAGACGTTTCTATCTCTTCCCAGT

>23059_23059_1_DLG2-CARD17_DLG2_chr11_83252725_ENST00000280241_CARD17_chr11_104970148_ENST00000375707_length(amino acids)=664AA_BP=639
MNAYLTKQHSCSRGSDGMDAVRSAPTLIRDAHCACGWQRNCQGLGYSSQTMPSSGPGGPASNRTGGSSFNRTLWDSVRKSPHKTSTKGKG
TCGEHCTCPHGWFSPAQASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAED
GRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGG
AAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPP
ISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQR
AVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQ
PEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSE

--------------------------------------------------------------
>23059_23059_2_DLG2-CARD17_DLG2_chr11_83252725_ENST00000330014_CARD17_chr11_104970148_ENST00000375707_length(transcript)=1811nt_BP=1636nt
AACAATGTGAACAAGCTATGCAACATGCATTTATTCCGGCCAGTCCTGCTCCTATAATTGTCAACACAGATACTTTGGACACAATTCCTT
ATGTCAATGGGACAGAAATTGAATATGAATTTGAAGAAATTACACTGGAGAGGGGGAATTCTGGCCTGGGATTCAGTATTGCTGGGGGGA
CAGATAATCCCCACATTGGAGATGACCCTGGCATATTTATTACGAAGATTATACCAGGAGGTGCTGCAGCAGAGGATGGCAGACTCAGGG
TCAATGATTGTATCTTGCGGGTGAATGAGGTTGATGTGTCAGAGGTTTCCCACAGTAAAGCGGTGGAAGCCCTGAAGGAAGCAGGGTCTA
TCGTTCGGCTGTATGTGCGTAGAAGACGACCTATTTTGGAGACCGTTGTGGAAATCAAACTGTTCAAAGGCCCTAAAGGTTTAGGCTTCA
GTATTGCAGGAGGTGTGGGGAACCAACACATTCCTGGAGACAACAGCATTTATGTAACTAAAATTATAGATGGAGGAGCTGCACAAAAAG
ATGGAAGGTTGCAAGTAGGAGATAGACTACTAATGGTAAACAACTACAGTTTAGAAGAAGTAACACACGAAGAGGCAGTAGCAATATTAA
AGAACACATCAGAGGTAGTTTATTTAAAAGTTGGCAAACCCACTACCATTTATATGACTGATCCTTATGGTCCACCTGATATTACTCACT
CTTATTCTCCACCAATGGAAAACCATCTACTCTCTGGCAACAATGGCACTTTAGAATATAAAACCTCCCTGCCACCCATCTCTCCAGGAA
GGTACTCACCAATTCCAAAGCACATGCTTGTTGACGACGACTACACCAGGCCTCCGGAACCTGTTTACAGCACTGTGAACAAACTATGTG
ATAAGCCTGCTTCTCCCAGGCACTATTCCCCTGTTGAGTGTGACAAAAGCTTCCTCCTCTCAGCTCCCTATTCCCACTACCACCTAGGCC
TGCTACCTGACTCTGAGATGACCAGTCATTCCCAACATAGCACCGCAACTCGTCAGCCTTCAATGACTCTCCAACGGGCCGTCTCCCTGG
AAGGAGAGCCTCGCAAGGTAGTCCTGCACAAAGGCTCCACTGGCCTGGGCTTCAACATTGTCGGTGGGGAAGATGGAGAAGGTATTTTTG
TGTCCTTCATTCTGGCTGGTGGACCAGCAGACCTAAGTGGGGAGCTCCAGAGAGGAGACCAGATCCTATCGGTGAATGGCATTGACCTCC
GTGGTGCATCCCACGAGCAGGCAGCTGCTGCACTAAAGGGGGCTGGACAGACAGTGACGATTATAGCACAATATCAACCTGAAGATTACG
CTCGATTTGAGGCCAAAATCCATGACCTACGAGAGCAGATGATGAACCACAGCATGAGCTCCGGGTCCGGATCCCTGCGAACCAATCAGA
AACGCTCCCTCTACGTCAGAGCCATGTTCGACTACGACAAGAGCAAGGACAGTGGGCTGCCAAGTCAAGGACTTAGTTTTAAATATGGAG
ATATTCTCCACGTTATCAATGCCTCTGATGATGAGTGGTGGCAAGCCAGGAGAGTCATGCTGGAGGGAGACAGTGAGGAGATGGGGGTCA
TCCCCAGCAAAAGGAGGTCCAACATCTGGAAATCACCTTACTACACAAGATTCTCAAATAGTACTTCCTTCCTAGGTTCAACTTTCATTT
GAGCAGCCAGATGATAAAGCACAGATGCCCAGCACTGAAAGAGTTACTTCGACAAGACGTTTCTATCTCTTCCCAGTACATTAAAATAAG

>23059_23059_2_DLG2-CARD17_DLG2_chr11_83252725_ENST00000330014_CARD17_chr11_104970148_ENST00000375707_length(amino acids)=564AA_BP=539
MQHAFIPASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCIL
RVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQV
GDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIP
KHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRK
VVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAK
IHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRR

--------------------------------------------------------------
>23059_23059_3_DLG2-CARD17_DLG2_chr11_83252725_ENST00000398309_CARD17_chr11_104970148_ENST00000375707_length(transcript)=2448nt_BP=2273nt
ATTTACAGTCTGCGATGCGATCCCATTGTAAAGTATTTAATAGGATAACACCGGGGCTCTCCAGAAATATAAGTAACTCATTGGTTAAAT
TTCAATTCTTCACCTTTCCCCCCCTCCTTCCTGAGTGAGCTCATTCCCCCCTCCTTCTTCTTCTTCTTTTTTTTTTTTAATCCAGTGATT
TAAAATGCTAGAAGGAAAAGCAACTGAGGTCTTAACTTTCAGACGCTGAATTCTCATCTAATTGAAATTACTGGGCATAATGCTATATAT
AGCCAATGAAGAGATTTTGAGCTCTCACTCAGTGCCTTCAAGACATGTCGTTTTGTAGTCAGAGAAAACAGAGATCAATGCATTTTCAAA
CTGACAGAGGGAACGGATGCTCTTTAGTAGCACATGCCCAGGATCGTGTGTGTGGGGCTTGCGCTGTGCTGAGAAGCTGAATACCGGTCC
ATATGCTCCTTATTTACTGCAATGTTCTTTGCATGTTACTGTGCACTCCGGACTAACGTGAAGAAGTATCGATATCAAGATGAGGACGCT
CCACATGATCATTCCTTACCTCGACTAACCCACGAAGTAAGAGGCCCAGAACTCGTGCATGTATCAGAAAAGAACCTCTCTCAAATAGAA
AATGTCCATGGATATGTCTTGCAGTCTCATATTTCTCCTCTGAAGGCCAGTCCTGCTCCTATAATTGTCAACACAGATACTTTGGACACA
ATTCCTTATGTCAATGGGACAGAAATTGAATATGAATTTGAAGAAATTACACTGGAGAGGGGGAATTCTGGCCTGGGATTCAGTATTGCT
GGGGGGACAGATAATCCCCACATTGGAGATGACCCTGGCATATTTATTACGAAGATTATACCAGGAGGTGCTGCAGCAGAGGATGGCAGA
CTCAGGGTCAATGATTGTATCTTGCGGGTGAATGAGGTTGATGTGTCAGAGGTTTCCCACAGTAAAGCGGTGGAAGCCCTGAAGGAAGCA
GGGTCTATCGTTCGGCTGTATGTGCGTAGAAGACGACCTATTTTGGAGACCGTTGTGGAAATCAAACTGTTCAAAGGCCCTAAAGGTTTA
GGCTTCAGTATTGCAGGAGGTGTGGGGAACCAACACATTCCTGGAGACAACAGCATTTATGTAACTAAAATTATAGATGGAGGAGCTGCA
CAAAAAGATGGAAGGTTGCAAGTAGGAGATAGACTACTAATGGTAAACAACTACAGTTTAGAAGAAGTAACACACGAAGAGGCAGTAGCA
ATATTAAAGAACACATCAGAGGTAGTTTATTTAAAAGTTGGCAAACCCACTACCATTTATATGACTGATCCTTATGGTCCACCTGATATT
ACTCACTCTTATTCTCCACCAATGGAAAACCATCTACTCTCTGGCAACAATGGCACTTTAGAATATAAAACCTCCCTGCCACCCATCTCT
CCAGGAAGGTACTCACCAATTCCAAAGCACATGCTTGTTGACGACGACTACACCAGGCCTCCGGAACCTGTTTACAGCACTGTGAACAAA
CTATGTGATAAGCCTGCTTCTCCCAGGCACTATTCCCCTGTTGAGTGTGACAAAAGCTTCCTCCTCTCAGCTCCCTATTCCCACTACCAC
CTAGGCCTGCTACCTGACTCTGAGATGACCAGTCATTCCCAACATAGCACCGCAACTCGTCAGCCTTCAATGACTCTCCAACGGGCCGTC
TCCCTGGAAGGAGAGCCTCGCAAGGTAGTCCTGCACAAAGGCTCCACTGGCCTGGGCTTCAACATTGTCGGTGGGGAAGATGGAGAAGGT
ATTTTTGTGTCCTTCATTCTGGCTGGTGGACCAGCAGACCTAAGTGGGGAGCTCCAGAGAGGAGACCAGATCCTATCGGTGAATGGCATT
GACCTCCGTGGTGCATCCCACGAGCAGGCAGCTGCTGCACTAAAGGGGGCTGGACAGACAGTGACGATTATAGCACAATATCAACCTGAA
GATTACGCTCGATTTGAGGCCAAAATCCATGACCTACGAGAGCAGATGATGAACCACAGCATGAGCTCCGGGTCCGGATCCCTGCGAACC
AATCAGAAACGCTCCCTCTACGTCAGAGCCATGTTCGACTACGACAAGAGCAAGGACAGTGGGCTGCCAAGTCAAGGACTTAGTTTTAAA
TATGGAGATATTCTCCACGTTATCAATGCCTCTGATGATGAGTGGTGGCAAGCCAGGAGAGTCATGCTGGAGGGAGACAGTGAGGAGATG
GGGGTCATCCCCAGCAAAAGGAGGTCCAACATCTGGAAATCACCTTACTACACAAGATTCTCAAATAGTACTTCCTTCCTAGGTTCAACT
TTCATTTGAGCAGCCAGATGATAAAGCACAGATGCCCAGCACTGAAAGAGTTACTTCGACAAGACGTTTCTATCTCTTCCCAGTACATTA

>23059_23059_3_DLG2-CARD17_DLG2_chr11_83252725_ENST00000398309_CARD17_chr11_104970148_ENST00000375707_length(amino acids)=625AA_BP=600
MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGT
EIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY
VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSE
VVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS
PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFIL
AGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY

--------------------------------------------------------------
>23059_23059_4_DLG2-CARD17_DLG2_chr11_83252725_ENST00000418306_CARD17_chr11_104970148_ENST00000375707_length(transcript)=1693nt_BP=1518nt
AGTTTGAGTGTTACCAGCTTTCGCTATGCAACGGCCAAGTGTTTCTCGGGCTGAGAATTATCAGCTTTTGTGGGATACTATTGCTTCCTT
AAAACAATGTGAACAAGCTATGCAACATGCATTTATTCCGGTCAATGGGACAGAAATTGAATATGAATTTGAAGAAATTACACTGGAGAG
GGGGAATTCTGGCCTGGGATTCAGTATTGCTGGGGGGACAGATAATCCCCACATTGGAGATGACCCTGGCATATTTATTACGAAGATTAT
ACCAGGAGGTGCTGCAGCAGAGGATGGCAGACTCAGGGTCAATGATTGTATCTTGCGGGTGAATGAGGTTGATGTGTCAGAGGTTTCCCA
CAGTAAAGCGGTGGAAGCCCTGAAGGAAGCAGGGTCTATCGTTCGGCTGTATGTGCGTAGAAGACGACCTATTTTGGAGACCGTTGTGGA
AATCAAACTGTTCAAAGGCCCTAAAGGTTTAGGCTTCAGTATTGCAGGAGGTGTGGGGAACCAACACATTCCTGGAGACAACAGCATTTA
TGTAACTAAAATTATAGATGGAGGAGCTGCACAAAAAGATGGAAGGTTGCAAGTAGGAGATAGACTACTAATGGTAAACAACTACAGTTT
AGAAGAAGTAACACACGAAGAGGCAGTAGCAATATTAAAGAACACATCAGAGGTAGTTTATTTAAAAGTTGGCAAACCCACTACCATTTA
TATGACTGATCCTTATGGTCCACCTGATATTACTCACTCTTATTCTCCACCAATGGAAAACCATCTACTCTCTGGCAACAATGGCACTTT
AGAATATAAAACCTCCCTGCCACCCATCTCTCCAGGAAGGTACTCACCAATTCCAAAGCACATGCTTGTTGACGACGACTACACCAGTCA
TTCCCAACATAGCACCGCAACTCGTCAGCCTTCAATGACTCTCCAACGGGCCGTCTCCCTGGAAGGAGAGCCTCGCAAGGTAGTCCTGCA
CAAAGGCTCCACTGGCCTGGGCTTCAACATTGTCGGTGGGGAAGATGGAGAAGGTATTTTTGTGTCCTTCATTCTGGCTGGTGGACCAGC
AGACCTAAGTGGGGAGCTCCAGAGAGGAGACCAGATCCTATCGGTGAATGGCATTGACCTCCGTGGTGCATCCCACGAGCAGGCAGCTGC
TGCACTAAAGGGGGCTGGACAGACAGTGACGATTATAGCACAATATCAACCTGAAGATTACGCTCGATTTGAGGCCAAAATCCATGACCT
ACGAGAGCAGATGATGAACCACAGCATGAGCTCCGGGTCCGGATCCCTGCGAACCAATCAGAAACGCTCCCTCTACGTCAGAGCCATGTT
CGACTACGACAAGAGCAAGGACAGTGGGCTGCCAAGTCAAGGACTTAGTTTTAAATATGGAGATATTCTCCACGTTATCAATGCCTCTGA
TGATGAGTGGTGGCAAGCCAGGAGAGTCATGCTGGAGGGAGACAGTGAGGAGATGGGGGTCATCCCCAGCAAAAGGAGGTCCAACATCTG
GAAATCACCTTACTACACAAGATTCTCAAATAGTACTTCCTTCCTAGGTTCAACTTTCATTTGAGCAGCCAGATGATAAAGCACAGATGC

>23059_23059_4_DLG2-CARD17_DLG2_chr11_83252725_ENST00000418306_CARD17_chr11_104970148_ENST00000375707_length(amino acids)=522AA_BP=497
MQRPSVSRAENYQLLWDTIASLKQCEQAMQHAFIPVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAED
GRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGG
AAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPP
ISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQR
GDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDS

--------------------------------------------------------------
>23059_23059_5_DLG2-CARD17_DLG2_chr11_83252725_ENST00000524982_CARD17_chr11_104970148_ENST00000375707_length(transcript)=2039nt_BP=1864nt
GTGTGGGGCTTGCGCTGTGCTGAGAAGCTGAATACCGGTCCATATGCTCCTTATTTACTGCAATGTTCTTTGCATGTTACTGTGCACTCC
GGACTAACGTGAAGAAGTATCGATATCAAGATGAGGACGCTCCACATGATCATTCCTTACCTCGACTAACCCACGAAGTAAGAGGCCCAG
AACTCGTGCATGTATCAGAAAAGAACCTCTCTCAAATAGAAAATGTCCATGGATATGTCTTGCAGTCTCATATTTCTCCTCTGAAGGCCA
GTCCTGCTCCTATAATTGTCAACACAGATACTTTGGACACAATTCCTTATGTCAATGGGACAGAAATTGAATATGAATTTGAAGAAATTA
CACTGGAGAGGGGGAATTCTGGCCTGGGATTCAGTATTGCTGGGGGGACAGATAATCCCCACATTGGAGATGACCCTGGCATATTTATTA
CGAAGATTATACCAGGAGGTGCTGCAGCAGAGGATGGCAGACTCAGGGTCAATGATTGTATCTTGCGGGTGAATGAGGTTGATGTGTCAG
AGGTTTCCCACAGTAAAGCGGTGGAAGCCCTGAAGGAAGCAGGGTCTATCGTTCGGCTGTATGTGCGTAGAAGACGACCTATTTTGGAGA
CCGTTGTGGAAATCAAACTGTTCAAAGGCCCTAAAGGTTTAGGCTTCAGTATTGCAGGAGGTGTGGGGAACCAACACATTCCTGGAGACA
ACAGCATTTATGTAACTAAAATTATAGATGGAGGAGCTGCACAAAAAGATGGAAGGTTGCAAGTAGGAGATAGACTACTAATGGTAAACA
ACTACAGTTTAGAAGAAGTAACACACGAAGAGGCAGTAGCAATATTAAAGAACACATCAGAGGTAGTTTATTTAAAAGTTGGCAAACCCA
CTACCATTTATATGACTGATCCTTATGGTCCACCTGATATTACTCACTCTTATTCTCCACCAATGGAAAACCATCTACTCTCTGGCAACA
ATGGCACTTTAGAATATAAAACCTCCCTGCCACCCATCTCTCCAGGAAGGTACTCACCAATTCCAAAGCACATGCTTGTTGACGACGACT
ACACCAGGCCTCCGGAACCTGTTTACAGCACTGTGAACAAACTATGTGATAAGCCTGCTTCTCCCAGGCACTATTCCCCTGTTGAGTGTG
ACAAAAGCTTCCTCCTCTCAGCTCCCTATTCCCACTACCACCTAGGCCTGCTACCTGACTCTGAGATGACCAGTCATTCCCAACATAGCA
CCGCAACTCGTCAGCCTTCAATGACTCTCCAACGGGCCGTCTCCCTGGAAGGAGAGCCTCGCAAGGTAGTCCTGCACAAAGGCTCCACTG
GCCTGGGCTTCAACATTGTCGGTGGGGAAGATGGAGAAGGTATTTTTGTGTCCTTCATTCTGGCTGGTGGACCAGCAGACCTAAGTGGGG
AGCTCCAGAGAGGAGACCAGATCCTATCGGTGAATGGCATTGACCTCCGTGGTGCATCCCACGAGCAGGCAGCTGCTGCACTAAAGGGGG
CTGGACAGACAGTGACGATTATAGCACAATATCAACCTGAAGATTACGCTCGATTTGAGGCCAAAATCCATGACCTACGAGAGCAGATGA
TGAACCACAGCATGAGCTCCGGGTCCGGATCCCTGCGAACCAATCAGAAACGCTCCCTCTACGTCAGAGCCATGTTCGACTACGACAAGA
GCAAGGACAGTGGGCTGCCAAGTCAAGGACTTAGTTTTAAATATGGAGATATTCTCCACGTTATCAATGCCTCTGATGATGAGTGGTGGC
AAGCCAGGAGAGTCATGCTGGAGGGAGACAGTGAGGAGATGGGGGTCATCCCCAGCAAAAGGAGGTCCAACATCTGGAAATCACCTTACT
ACACAAGATTCTCAAATAGTACTTCCTTCCTAGGTTCAACTTTCATTTGAGCAGCCAGATGATAAAGCACAGATGCCCAGCACTGAAAGA

>23059_23059_5_DLG2-CARD17_DLG2_chr11_83252725_ENST00000524982_CARD17_chr11_104970148_ENST00000375707_length(amino acids)=625AA_BP=600
MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGT
EIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY
VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSE
VVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS
PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFIL
AGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY

--------------------------------------------------------------
>23059_23059_6_DLG2-CARD17_DLG2_chr11_83252725_ENST00000530800_CARD17_chr11_104970148_ENST00000375707_length(transcript)=568nt_BP=393nt
TATACACCAAGCAGCTCAACCAGGAGGAGGGAACAGAGCTGAATTTGGGAAGCAGCTGCCTGCTATGCTGAAAACCCCTGGAAACTTGCT
AAAGAGCTGTGATTACGCTCGATTTGAGGCCAAAATCCATGACCTACGAGAGCAGATGATGAACCACAGCATGAGCTCCGGGTCCGGATC
CCTGCGAACCAATCAGAAACGCTCCCTCTACGTCAGAGCCATGTTCGACTACGACAAGAGCAAGGACAGTGGGCTGCCAAGTCAAGGACT
TAGTTTTAAATATGGAGATATTCTCCACGTTATCAATGCCTCTGATGATGAGTGGTGGCAAGCCAGGAGAGTCATGCTGGAGGGAGACAG
TGAGGAGATGGGGGTCATCCCCAGCAAAAGGAGGTCCAACATCTGGAAATCACCTTACTACACAAGATTCTCAAATAGTACTTCCTTCCT
AGGTTCAACTTTCATTTGAGCAGCCAGATGATAAAGCACAGATGCCCAGCACTGAAAGAGTTACTTCGACAAGACGTTTCTATCTCTTCC

>23059_23059_6_DLG2-CARD17_DLG2_chr11_83252725_ENST00000530800_CARD17_chr11_104970148_ENST00000375707_length(amino acids)=137AA_BP=112
MPAMLKTPGNLLKSCDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW

--------------------------------------------------------------
>23059_23059_7_DLG2-CARD17_DLG2_chr11_83252725_ENST00000531015_CARD17_chr11_104970148_ENST00000375707_length(transcript)=1903nt_BP=1728nt
AGTTTGAGTGTTACCAGCTTTCGCTATGCAACGGCCAAGTGTTTCTCGGGCTGAGAATTATCAGCTTTTGTGGGATACTATTGCTTCCTT
AAAACAATGTGAACAAGCTATGCAACATGCATTTATTCCGGCCAGTCCTGCTCCTATAATTGTCAACACAGATACTTTGGACACAATTCC
TTATGTCAATGGGACAGAAATTGAATATGAATTTGAAGAAATTACACTGGAGAGGGGGAATTCTGGCCTGGGATTCAGTATTGCTGGGGG
GACAGATAATCCCCACATTGGAGATGACCCTGGCATATTTATTACGAAGATTATACCAGGAGGTGCTGCAGCAGAGGATGGCAGACTCAG
GGTCAATGATTGTATCTTGCGGGTGAATGAGGTTGATGTGTCAGAGGTTTCCCACAGTAAAGCGGTGGAAGCCCTGAAGGAAGCAGGGTC
TATCGTTCGGCTGTATGTGCGTAGAAGACGACCTATTTTGGAGACCGTTGTGGAAATCAAACTGTTCAAAGGCCCTAAAGGTTTAGGCTT
CAGTATTGCAGGAGGTGTGGGGAACCAACACATTCCTGGAGACAACAGCATTTATGTAACTAAAATTATAGATGGAGGAGCTGCACAAAA
AGATGGAAGGTTGCAAGTAGGAGATAGACTACTAATGGTAAACAACTACAGTTTAGAAGAAGTAACACACGAAGAGGCAGTAGCAATATT
AAAGAACACATCAGAGGTAGTTTATTTAAAAGTTGGCAAACCCACTACCATTTATATGACTGATCCTTATGGTCCACCTGATATTACTCA
CTCTTATTCTCCACCAATGGAAAACCATCTACTCTCTGGCAACAATGGCACTTTAGAATATAAAACCTCCCTGCCACCCATCTCTCCAGG
AAGGTACTCACCAATTCCAAAGCACATGCTTGTTGACGACGACTACACCAGGCCTCCGGAACCTGTTTACAGCACTGTGAACAAACTATG
TGATAAGCCTGCTTCTCCCAGGCACTATTCCCCTGTTGAGTGTGACAAAAGCTTCCTCCTCTCAGCTCCCTATTCCCACTACCACCTAGG
CCTGCTACCTGACTCTGAGATGACCAGTCATTCCCAACATAGCACCGCAACTCGTCAGCCTTCAATGACTCTCCAACGGGCCGTCTCCCT
GGAAGGAGAGCCTCGCAAGGTAGTCCTGCACAAAGGCTCCACTGGCCTGGGCTTCAACATTGTCGGTGGGGAAGATGGAGAAGGTATTTT
TGTGTCCTTCATTCTGGCTGGTGGACCAGCAGACCTAAGTGGGGAGCTCCAGAGAGGAGACCAGATCCTATCGGTGAATGGCATTGACCT
CCGTGGTGCATCCCACGAGCAGGCAGCTGCTGCACTAAAGGGGGCTGGACAGACAGTGACGATTATAGCACAATATCAACCTGAAGATTA
CGCTCGATTTGAGGCCAAAATCCATGACCTACGAGAGCAGATGATGAACCACAGCATGAGCTCCGGGTCCGGATCCCTGCGAACCAATCA
GAAACGCTCCCTCTACGTCAGAGCCATGTTCGACTACGACAAGAGCAAGGACAGTGGGCTGCCAAGTCAAGGACTTAGTTTTAAATATGG
AGATATTCTCCACGTTATCAATGCCTCTGATGATGAGTGGTGGCAAGCCAGGAGAGTCATGCTGGAGGGAGACAGTGAGGAGATGGGGGT
CATCCCCAGCAAAAGGAGGTCCAACATCTGGAAATCACCTTACTACACAAGATTCTCAAATAGTACTTCCTTCCTAGGTTCAACTTTCAT
TTGAGCAGCCAGATGATAAAGCACAGATGCCCAGCACTGAAAGAGTTACTTCGACAAGACGTTTCTATCTCTTCCCAGTACATTAAAATA

>23059_23059_7_DLG2-CARD17_DLG2_chr11_83252725_ENST00000531015_CARD17_chr11_104970148_ENST00000375707_length(amino acids)=592AA_BP=567
MQRPSVSRAENYQLLWDTIASLKQCEQAMQHAFIPASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGD
DPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGN
QHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMEN
HLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMT
SHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQA
AAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINA

--------------------------------------------------------------
>23059_23059_8_DLG2-CARD17_DLG2_chr11_83252725_ENST00000532653_CARD17_chr11_104970148_ENST00000375707_length(transcript)=2280nt_BP=2105nt
AATCCAGTGATTTAAAATGCTAGAAGGAAAAGCAACTGAGGTCTTAACTTTCAGACGCTGAATTCTCATCTAATTGAAATTACTGGGCAT
AATGCTATATATAGCCAATGAAGAGATTTTGAGCTCTCACTCAGTGCCTTCAAGACATGTCGTTTTGTAGTCAGAGAAAACAGAGATCAA
TGCATTTTCAAACTGACAGAGGGAACGGATGCTCTTTAGTAGCACATGCCCAGGATCGTGTGTGTGGGGCTTGCGCTGTGCTGAGAAGCT
GAATACCGGTCCATATGCTCCTTATTTACTGCAATGTTCTTTGCATGTTACTGTGCACTCCGGACTAACGTGAAGAAGTATCGATATCAA
GATGAGGACGCTCCACATGATCATTCCTTACCTCGACTAACCCACGAAGTAAGAGGCCCAGAACTCGTGCATGTATCAGAAAAGAACCTC
TCTCAAATAGAAAATGTCCATGGATATGTCTTGCAGTCTCATATTTCTCCTCTGAAGGCCAGTCCTGCTCCTATAATTGTCAACACAGAT
ACTTTGGACACAATTCCTTATGTCAATGGGACAGAAATTGAATATGAATTTGAAGAAATTACACTGGAGAGGGGGAATTCTGGCCTGGGA
TTCAGTATTGCTGGGGGGACAGATAATCCCCACATTGGAGATGACCCTGGCATATTTATTACGAAGATTATACCAGGAGGTGCTGCAGCA
GAGGATGGCAGACTCAGGGTCAATGATTGTATCTTGCGGGTGAATGAGGTTGATGTGTCAGAGGTTTCCCACAGTAAAGCGGTGGAAGCC
CTGAAGGAAGCAGGGTCTATCGTTCGGCTGTATGTGCGTAGAAGACGACCTATTTTGGAGACCGTTGTGGAAATCAAACTGTTCAAAGGC
CCTAAAGGTTTAGGCTTCAGTATTGCAGGAGGTGTGGGGAACCAACACATTCCTGGAGACAACAGCATTTATGTAACTAAAATTATAGAT
GGAGGAGCTGCACAAAAAGATGGAAGGTTGCAAGTAGGAGATAGACTACTAATGGTAAACAACTACAGTTTAGAAGAAGTAACACACGAA
GAGGCAGTAGCAATATTAAAGAACACATCAGAGGTAGTTTATTTAAAAGTTGGCAAACCCACTACCATTTATATGACTGATCCTTATGGT
CCACCTGATATTACTCACTCTTATTCTCCACCAATGGAAAACCATCTACTCTCTGGCAACAATGGCACTTTAGAATATAAAACCTCCCTG
CCACCCATCTCTCCAGGAAGGTACTCACCAATTCCAAAGCACATGCTTGTTGACGACGACTACACCAGGCCTCCGGAACCTGTTTACAGC
ACTGTGAACAAACTATGTGATAAGCCTGCTTCTCCCAGGCACTATTCCCCTGTTGAGTGTGACAAAAGCTTCCTCCTCTCAGCTCCCTAT
TCCCACTACCACCTAGGCCTGCTACCTGACTCTGAGATGACCAGTCATTCCCAACATAGCACCGCAACTCGTCAGCCTTCAATGACTCTC
CAACGGGCCGTCTCCCTGGAAGGAGAGCCTCGCAAGGTAGTCCTGCACAAAGGCTCCACTGGCCTGGGCTTCAACATTGTCGGTGGGGAA
GATGGAGAAGGTATTTTTGTGTCCTTCATTCTGGCTGGTGGACCAGCAGACCTAAGTGGGGAGCTCCAGAGAGGAGACCAGATCCTATCG
GTGAATGGCATTGACCTCCGTGGTGCATCCCACGAGCAGGCAGCTGCTGCACTAAAGGGGGCTGGACAGACAGTGACGATTATAGCACAA
TATCAACCTGAAGATTACGCTCGATTTGAGGCCAAAATCCATGACCTACGAGAGCAGATGATGAACCACAGCATGAGCTCCGGGTCCGGA
TCCCTGCGAACCAATCAGAAACGCTCCCTCTACGTCAGAGCCATGTTCGACTACGACAAGAGCAAGGACAGTGGGCTGCCAAGTCAAGGA
CTTAGTTTTAAATATGGAGATATTCTCCACGTTATCAATGCCTCTGATGATGAGTGGTGGCAAGCCAGGAGAGTCATGCTGGAGGGAGAC
AGTGAGGAGATGGGGGTCATCCCCAGCAAAAGGAGGTCCAACATCTGGAAATCACCTTACTACACAAGATTCTCAAATAGTACTTCCTTC
CTAGGTTCAACTTTCATTTGAGCAGCCAGATGATAAAGCACAGATGCCCAGCACTGAAAGAGTTACTTCGACAAGACGTTTCTATCTCTT

>23059_23059_8_DLG2-CARD17_DLG2_chr11_83252725_ENST00000532653_CARD17_chr11_104970148_ENST00000375707_length(amino acids)=625AA_BP=600
MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGT
EIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY
VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSE
VVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS
PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFIL
AGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY

--------------------------------------------------------------
>23059_23059_9_DLG2-CARD17_DLG2_chr11_83252725_ENST00000543673_CARD17_chr11_104970148_ENST00000375707_length(transcript)=2292nt_BP=2117nt
ATGGGTATCTTTAAGAGCAGCTTATTCCAAGCTTTGCTAGATATCCAAGAATTTTATGAGGTGACATTGCTAAATTCTCAAAAAAGTTGT
GAGCAGAAGATAGAAGAAGCCAATCAAGTTTTACAGAAATGGGAGAAGACATCCCTTCTTGCTCCGTGCCATGACAGACTTCAAAAATCT
TCAGAGCTTACAGATTGCAGTGGATCAAAGGAAAATGCTTCATGTATTGAGCAAAATAAAGAAAATCAGAGTTTTGAAAATGAAACTGAT
GAGACGACAACTCAAAACCAAGGCAGATGCCCAGCCCAGAATTGTTCAGTGGAAGCCCCTGCTTGGATGCCTGTCCACCACTGTACTAAG
TATCGATATCAAGATGAGGACGCTCCACATGATCATTCCTTACCTCGACTAACCCACGAAGTAAGAGGCCCAGAACTCGTGCATGTATCA
GAAAAGAACCTCTCTCAAATAGAAAATGTCCATGGATATGTCTTGCAGTCTCATATTTCTCCTCTGAAGGCCAGTCCTGCTCCTATAATT
GTCAACACAGATACTTTGGACACAATTCCTTATGTCAATGGGACAGAAATTGAATATGAATTTGAAGAAATTACACTGGAGAGGGGGAAT
TCTGGCCTGGGATTCAGTATTGCTGGGGGGACAGATAATCCCCACATTGGAGATGACCCTGGCATATTTATTACGAAGATTATACCAGGA
GGTGCTGCAGCAGAGGATGGCAGACTCAGGGTCAATGATTGTATCTTGCGGGTGAATGAGGTTGATGTGTCAGAGGTTTCCCACAGTAAA
GCGGTGGAAGCCCTGAAGGAAGCAGGGTCTATCGTTCGGCTGTATGTGCGTAGAAGACGACCTATTTTGGAGACCGTTGTGGAAATCAAA
CTGTTCAAAGGCCCTAAAGGTTTAGGCTTCAGTATTGCAGGAGGTGTGGGGAACCAACACATTCCTGGAGACAACAGCATTTATGTAACT
AAAATTATAGATGGAGGAGCTGCACAAAAAGATGGAAGGTTGCAAGTAGGAGATAGACTACTAATGGTAAACAACTACAGTTTAGAAGAA
GTAACACACGAAGAGGCAGTAGCAATATTAAAGAACACATCAGAGGTAGTTTATTTAAAAGTTGGCAAACCCACTACCATTTATATGACT
GATCCTTATGGTCCACCTGATATTACTCACTCTTATTCTCCACCAATGGAAAACCATCTACTCTCTGGCAACAATGGCACTTTAGAATAT
AAAACCTCCCTGCCACCCATCTCTCCAGGAAGGTACTCACCAATTCCAAAGCACATGCTTGTTGACGACGACTACACCAGGCCTCCGGAA
CCTGTTTACAGCACTGTGAACAAACTATGTGATAAGCCTGCTTCTCCCAGGCACTATTCCCCTGTTGAGTGTGACAAAAGCTTCCTCCTC
TCAGCTCCCTATTCCCACTACCACCTAGGCCTGCTACCTGACTCTGAGATGACCAGTCATTCCCAACATAGCACCGCAACTCGTCAGCCT
TCAATGACTCTCCAACGGGCCGTCTCCCTGGAAGGAGAGCCTCGCAAGGTAGTCCTGCACAAAGGCTCCACTGGCCTGGGCTTCAACATT
GTCGGTGGGGAAGATGGAGAAGGTATTTTTGTGTCCTTCATTCTGGCTGGTGGACCAGCAGACCTAAGTGGGGAGCTCCAGAGAGGAGAC
CAGATCCTATCGGTGAATGGCATTGACCTCCGTGGTGCATCCCACGAGCAGGCAGCTGCTGCACTAAAGGGGGCTGGACAGACAGTGACG
ATTATAGCACAATATCAACCTGAAGATTACGCTCGATTTGAGGCCAAAATCCATGACCTACGAGAGCAGATGATGAACCACAGCATGAGC
TCCGGGTCCGGATCCCTGCGAACCAATCAGAAACGCTCCCTCTACGTCAGAGCCATGTTCGACTACGACAAGAGCAAGGACAGTGGGCTG
CCAAGTCAAGGACTTAGTTTTAAATATGGAGATATTCTCCACGTTATCAATGCCTCTGATGATGAGTGGTGGCAAGCCAGGAGAGTCATG
CTGGAGGGAGACAGTGAGGAGATGGGGGTCATCCCCAGCAAAAGGAGGTCCAACATCTGGAAATCACCTTACTACACAAGATTCTCAAAT
AGTACTTCCTTCCTAGGTTCAACTTTCATTTGAGCAGCCAGATGATAAAGCACAGATGCCCAGCACTGAAAGAGTTACTTCGACAAGACG

>23059_23059_9_DLG2-CARD17_DLG2_chr11_83252725_ENST00000543673_CARD17_chr11_104970148_ENST00000375707_length(amino acids)=730AA_BP=705
MGIFKSSLFQALLDIQEFYEVTLLNSQKSCEQKIEEANQVLQKWEKTSLLAPCHDRLQKSSELTDCSGSKENASCIEQNKENQSFENETD
ETTTQNQGRCPAQNCSVEAPAWMPVHHCTKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPII
VNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSK
AVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEE
VTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPE
PVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNI
VGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMS
SGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRSNIWKSPYYTRFSN

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Fusion Gene PPI Analysis for DLG2-CARD17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DLG2-CARD17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DLG2-CARD17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource