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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DLGAP1-ARHGAP28 (FusionGDB2 ID:23109)

Fusion Gene Summary for DLGAP1-ARHGAP28

Fusion gene summary

Fusion gene information	Fusion gene name: DLGAP1-ARHGAP28
	Fusion gene ID: 23109
		Hgene	Tgene
	Gene symbol	DLGAP1	ARHGAP28
	Gene ID	9229	79822
	Gene name	DLG associated protein 1	Rho GTPase activating protein 28
	Synonyms	DAP-1\|DAP-1-ALPHA\|DAP-1-BETA\|DAP1\|DLGAP1A\|DLGAP1B\|GKAP\|SAPAP1	-
	Cytomap	18p11.31	18p11.31
	Type of gene	protein-coding	protein-coding
	Description	disks large-associated protein 1PSD-95/SAP90 binding protein 1SAP90/PSD-95-associated protein 1discs large homolog associated protein 1guanylate kinase-associated protein	rho GTPase-activating protein 28rho-type GTPase-activating protein 28
	Modification date	20200313	20200313
	UniProtAcc	O14490	Q9P2N2
	Ensembl transtripts involved in fusion gene	ENST00000315677, ENST00000581527, ENST00000400145, ENST00000400147, ENST00000400149, ENST00000400150, ENST00000400155, ENST00000478161, ENST00000515196, ENST00000534970, ENST00000539435, ENST00000581699, ENST00000584874,	ENST00000383472, ENST00000400091, ENST00000262227, ENST00000314319, ENST00000418986, ENST00000419673, ENST00000531294, ENST00000532996,
Fusion gene scores	* DoF score	37 X 27 X 8=7992	3 X 4 X 3=36
	# samples	37	4
	** MAII score	log2(37/7992*10)=-4.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: DLGAP1 [Title/Abstract] AND ARHGAP28 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DLGAP1(4455006)-ARHGAP28(6824761), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across DLGAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ARHGAP28 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-EJ-7791-01A	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
ChimerDB4	PRAD	TCGA-EJ-7791	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+

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Fusion Gene ORF analysis for DLGAP1-ARHGAP28

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000315677	ENST00000383472	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
5UTR-3CDS	ENST00000315677	ENST00000400091	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
5UTR-3CDS	ENST00000581527	ENST00000383472	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
5UTR-3CDS	ENST00000581527	ENST00000400091	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
5UTR-5UTR	ENST00000315677	ENST00000262227	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
5UTR-5UTR	ENST00000581527	ENST00000262227	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
5UTR-intron	ENST00000315677	ENST00000314319	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
5UTR-intron	ENST00000315677	ENST00000418986	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
5UTR-intron	ENST00000315677	ENST00000419673	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
5UTR-intron	ENST00000315677	ENST00000531294	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
5UTR-intron	ENST00000315677	ENST00000532996	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
5UTR-intron	ENST00000581527	ENST00000314319	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
5UTR-intron	ENST00000581527	ENST00000418986	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
5UTR-intron	ENST00000581527	ENST00000419673	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
5UTR-intron	ENST00000581527	ENST00000531294	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
5UTR-intron	ENST00000581527	ENST00000532996	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-3CDS	ENST00000400145	ENST00000383472	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-3CDS	ENST00000400145	ENST00000400091	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-3CDS	ENST00000400147	ENST00000383472	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-3CDS	ENST00000400147	ENST00000400091	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-3CDS	ENST00000400149	ENST00000383472	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-3CDS	ENST00000400149	ENST00000400091	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-3CDS	ENST00000400150	ENST00000383472	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-3CDS	ENST00000400150	ENST00000400091	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-3CDS	ENST00000400155	ENST00000383472	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-3CDS	ENST00000400155	ENST00000400091	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-3CDS	ENST00000478161	ENST00000383472	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-3CDS	ENST00000478161	ENST00000400091	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-3CDS	ENST00000515196	ENST00000383472	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-3CDS	ENST00000515196	ENST00000400091	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-3CDS	ENST00000534970	ENST00000383472	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-3CDS	ENST00000534970	ENST00000400091	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-3CDS	ENST00000539435	ENST00000383472	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-3CDS	ENST00000539435	ENST00000400091	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-3CDS	ENST00000581699	ENST00000383472	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-3CDS	ENST00000581699	ENST00000400091	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-3CDS	ENST00000584874	ENST00000383472	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-3CDS	ENST00000584874	ENST00000400091	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-5UTR	ENST00000400145	ENST00000262227	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-5UTR	ENST00000400147	ENST00000262227	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-5UTR	ENST00000400149	ENST00000262227	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-5UTR	ENST00000400150	ENST00000262227	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-5UTR	ENST00000400155	ENST00000262227	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-5UTR	ENST00000478161	ENST00000262227	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-5UTR	ENST00000515196	ENST00000262227	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-5UTR	ENST00000534970	ENST00000262227	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-5UTR	ENST00000539435	ENST00000262227	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-5UTR	ENST00000581699	ENST00000262227	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-5UTR	ENST00000584874	ENST00000262227	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400145	ENST00000314319	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400145	ENST00000418986	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400145	ENST00000419673	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400145	ENST00000531294	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400145	ENST00000532996	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400147	ENST00000314319	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400147	ENST00000418986	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400147	ENST00000419673	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400147	ENST00000531294	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400147	ENST00000532996	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400149	ENST00000314319	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400149	ENST00000418986	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400149	ENST00000419673	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400149	ENST00000531294	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400149	ENST00000532996	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400150	ENST00000314319	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400150	ENST00000418986	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400150	ENST00000419673	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400150	ENST00000531294	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400150	ENST00000532996	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400155	ENST00000314319	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400155	ENST00000418986	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400155	ENST00000419673	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400155	ENST00000531294	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000400155	ENST00000532996	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000478161	ENST00000314319	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000478161	ENST00000418986	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000478161	ENST00000419673	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000478161	ENST00000531294	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000478161	ENST00000532996	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000515196	ENST00000314319	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000515196	ENST00000418986	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000515196	ENST00000419673	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000515196	ENST00000531294	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000515196	ENST00000532996	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000534970	ENST00000314319	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000534970	ENST00000418986	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000534970	ENST00000419673	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000534970	ENST00000531294	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000534970	ENST00000532996	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000539435	ENST00000314319	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000539435	ENST00000418986	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000539435	ENST00000419673	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000539435	ENST00000531294	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000539435	ENST00000532996	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000581699	ENST00000314319	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000581699	ENST00000418986	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000581699	ENST00000419673	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000581699	ENST00000531294	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000581699	ENST00000532996	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000584874	ENST00000314319	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000584874	ENST00000418986	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000584874	ENST00000419673	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000584874	ENST00000531294	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+
intron-intron	ENST00000584874	ENST00000532996	DLGAP1	chr18	4455006	-	ARHGAP28	chr18	6824761	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for DLGAP1-ARHGAP28

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
DLGAP1	chr18	4455005	-	ARHGAP28	chr18	6824760	+	5.78E-07	0.9999994
DLGAP1	chr18	4455005	-	ARHGAP28	chr18	6824760	+	5.78E-07	0.9999994
DLGAP1	chr18	4455005	-	ARHGAP28	chr18	6824760	+	5.78E-07	0.9999994
DLGAP1	chr18	4455005	-	ARHGAP28	chr18	6824760	+	5.78E-07	0.9999994

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DLGAP1-ARHGAP28

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:4455006/:6824761)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DLGAP1 O14490	ARHGAP28 Q9P2N2
FUNCTION: Part of the postsynaptic scaffold in neuronal cells.	FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for DLGAP1-ARHGAP28

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DLGAP1-ARHGAP28

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for DLGAP1-ARHGAP28

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for DLGAP1-ARHGAP28

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source