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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DLGAP1-XRCC6BP1 (FusionGDB2 ID:23149)

Fusion Gene Summary for DLGAP1-XRCC6BP1

check button Fusion gene summary
Fusion gene informationFusion gene name: DLGAP1-XRCC6BP1
Fusion gene ID: 23149
HgeneTgene
Gene symbol

DLGAP1

XRCC6BP1

Gene ID

9229

91419

Gene nameDLG associated protein 1ATP23 metallopeptidase and ATP synthase assembly factor homolog
SynonymsDAP-1|DAP-1-ALPHA|DAP-1-BETA|DAP1|DLGAP1A|DLGAP1B|GKAP|SAPAP1KUB3|XRCC6BP1
Cytomap

18p11.31

12q14.1

Type of geneprotein-codingprotein-coding
Descriptiondisks large-associated protein 1PSD-95/SAP90 binding protein 1SAP90/PSD-95-associated protein 1discs large homolog associated protein 1guanylate kinase-associated proteinmitochondrial inner membrane protease ATP23 homologKu70-binding protein 3XRCC6-binding protein 1
Modification date2020031320200320
UniProtAcc

O14490

.
Ensembl transtripts involved in fusion geneENST00000315677, ENST00000400145, 
ENST00000400147, ENST00000400149, 
ENST00000400150, ENST00000400155, 
ENST00000515196, ENST00000534970, 
ENST00000539435, ENST00000581527, 
ENST00000581699, ENST00000584874, 
ENST00000478161, 		ENST00000546709, 
ENST00000300145, 
Fusion gene scores* DoF score37 X 27 X 8=799218 X 7 X 5=630
# samples 3721
** MAII scorelog2(37/7992*10)=-4.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/630*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DLGAP1 [Title/Abstract] AND XRCC6BP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDLGAP1(3729135)-XRCC6BP1(58350470), # samples:1
Anticipated loss of major functional domain due to fusion event.DLGAP1-XRCC6BP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DLGAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across XRCC6BP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-J4-A67L-01ADLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+


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Fusion Gene ORF analysis for DLGAP1-XRCC6BP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000315677ENST00000546709DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
5CDS-3UTRENST00000400145ENST00000546709DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
5CDS-3UTRENST00000400147ENST00000546709DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
5CDS-3UTRENST00000400149ENST00000546709DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
5CDS-3UTRENST00000400150ENST00000546709DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
5CDS-3UTRENST00000400155ENST00000546709DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
5CDS-3UTRENST00000515196ENST00000546709DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
5CDS-3UTRENST00000534970ENST00000546709DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
5CDS-3UTRENST00000539435ENST00000546709DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
5CDS-3UTRENST00000581527ENST00000546709DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
5CDS-3UTRENST00000581699ENST00000546709DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
5CDS-3UTRENST00000584874ENST00000546709DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
5UTR-3CDSENST00000478161ENST00000300145DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
5UTR-3UTRENST00000478161ENST00000546709DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
Frame-shiftENST00000315677ENST00000300145DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
Frame-shiftENST00000400145ENST00000300145DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
Frame-shiftENST00000400147ENST00000300145DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
Frame-shiftENST00000400149ENST00000300145DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
Frame-shiftENST00000400150ENST00000300145DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
Frame-shiftENST00000400155ENST00000300145DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
Frame-shiftENST00000534970ENST00000300145DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
Frame-shiftENST00000539435ENST00000300145DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
Frame-shiftENST00000581527ENST00000300145DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
Frame-shiftENST00000581699ENST00000300145DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
Frame-shiftENST00000584874ENST00000300145DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+
In-frameENST00000515196ENST00000300145DLGAP1chr18

3729135

-XRCC6BP1chr12

58350470

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000515196DLGAP1chr183729135-ENST00000300145XRCC6BP1chr1258350470+244318602691903544

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000515196ENST00000300145DLGAP1chr183729135-XRCC6BP1chr1258350470+0.040578580.9594214

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Fusion Genomic Features for DLGAP1-XRCC6BP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DLGAP1chr183729134-XRCC6BP1chr1258350469+0.0004171180.9995828
DLGAP1chr183729134-XRCC6BP1chr1258350469+0.0004171180.9995828

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DLGAP1-XRCC6BP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:3729135/chr12:58350470)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DLGAP1

O14490

.
FUNCTION: Part of the postsynaptic scaffold in neuronal cells.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000315677-713622_630530978.0Compositional biasNote=Poly-Thr
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000400145-49622_630228628.0Compositional biasNote=Poly-Thr
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000400147-410622_630228676.0Compositional biasNote=Poly-Thr
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000400155-410622_630236684.0Compositional biasNote=Poly-Thr
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000515196-611622_630530930.0Compositional biasNote=Poly-Thr
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000534970-410622_630242662.0Compositional biasNote=Poly-Thr
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000539435-411622_630228686.0Compositional biasNote=Poly-Thr
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000581527-712622_630530930.0Compositional biasNote=Poly-Thr
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000581699-410622_630236684.0Compositional biasNote=Poly-Thr
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000584874-410622_630530978.0Compositional biasNote=Poly-Thr
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000315677-713975_977530978.0MotifPDZ-binding
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000400145-49975_977228628.0MotifPDZ-binding
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000400147-410975_977228676.0MotifPDZ-binding
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000400155-410975_977236684.0MotifPDZ-binding
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000515196-611975_977530930.0MotifPDZ-binding
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000534970-410975_977242662.0MotifPDZ-binding
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000539435-411975_977228686.0MotifPDZ-binding
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000581527-712975_977530930.0MotifPDZ-binding
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000581699-410975_977236684.0MotifPDZ-binding
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000584874-410975_977530978.0MotifPDZ-binding


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Fusion Gene Sequence for DLGAP1-XRCC6BP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>23149_23149_1_DLGAP1-XRCC6BP1_DLGAP1_chr18_3729135_ENST00000515196_XRCC6BP1_chr12_58350470_ENST00000300145_length(transcript)=2443nt_BP=1860nt
CAGAGCAGTTGAACATCAGATACCCAGAGTGACATCAGGTTAAAAAAAAGCCTGCAATTTGGATCTTTTCCTGACTCGGAAGCAAGGAAA
ATGGACAATTGATAATCAAAGGCTAAATCTCTTCTGGGATCCACTGAATGCCACTAGAGGGTCTGCTCGAGAGAATTCCTGATTGAATGA
CAACGGCGCTAAGAACAATCCCTGCCCAAGACGGGTCTGGAGCCTGACTTCCGGGTGTCCATGACCCTGGCGGCTGCTTCCGGTCCGCCA
TGAAAGGGCTATCAGGCAGCCGCAGCCATCACCACGGGGTCACCTGCGACTCGGCCTGTGACTCGCTGTCGCACCACTCCGACCGCAAGC
CCTACCTGCTGAGCCCAGTGGAGCACCACCCCGCAGACCACCCATACTACACCCAGCGGAACTCCTTCCAGGCTGAGTGCGTGGGCCCCT
TCAGCGACCCGCTGGCCAGCAGCACCTTCCCCCGCAGGCACTACACCTCGCAGCAAGAGCTGAAGGACGAGTGTGCCCTGGTGCCCCGCA
CCCTGGCCACCAAGGCGAACCGCATCCCCGCCAACCTGCTGGACCAGTTCGAGCGGCAGCTGCCACTCAGCCGCGATGGCTATCACACCC
TGCAGTACAAGCGCACGGCCGTGGAGCACCGCAGCGACAGCCCCGGCCGCATCCGCCACCTGGTGCACTCGGTCCAGAAGCTCTTCACCA
AGTCGCACTCCCTGGAGGGGCCGTCCAAGGGCAGCGTCAACGGGGGCAAGGCCAGCCCTGACGAGGCGCAGGCGGCGCGCTATGGCAAAC
GCAGCAAGAGCAAGGAGCGGCGCGCGGAGCCCAAGGCCCGGCCCAGCACCTCCCCGGGCTGGTGGAGCTCGGACGACAACCTGGATGGTG
ACATGTGCATCTACCACGCCCCCTCGGGCGTGATGACCATGGGCAGGTGCCCCGACCGCTCGGCCTCACAGTACTTCCTGGAGGCCTACA
ACACCATCAGCGAGCAGGCGGTGAAGGCCTCCCGGAGCAACAACGACGTCAAGTGCTCCACCTGCGCCAACCTGCCGGTCAGCCTGGACA
CCCCGCTGCTGAAGAAGAGCGCCTGGTCCTCCACGCTCACCGTGAGCCGGGCCCGGGAGGTTTACCAGAAGGCCTCGGTGAACATGGACC
AGGCCATGGTGAAGTCCGAGTCGTGTCAGCAAGAACGCTCCTGCCAGTACCTGCAGGTTCCACAAGATGAATGGACAGGGTACACCCCAC
GAGGTAAAGATGATGAAATTCCATGCCGAAGAATGCGGAGTGGCAGTTATATCAAGGCCATGGGGGATGAAGACAGTGGAGACTCAGACA
CGAGTCCTAAGCCTTCTCCAAAAGTTGCTGCGCGGAGAGAAAGCTATCTCAAGGCTACTCAGCCATCCCTTACAGAACTCACCACACTCA
AAATCTCCAATGAACACTCACCCAAACTCCAGATCCGGAGTCATAGTTACCTGAGGGCAGTGAGTGAAGTCTCCATCAACCGGAGCCTGG
ACAGCCTGGACCCTGCAGGCTTGCTCACATCACCAAAGTTCCGCTCCAGGAATGAGAGCTACATGCGAGCCATGAGCACCATCAGCCAGG
TGAGCGAGATGGAAGTGAACGGGCAGTTCGAGTCCGTGTGCGAGTCCGTGTTCAGCGAGCTGGAGTCGCAGGCCGTGGAAGCGCTGGACC
TGCCCATGCCCGGCTGCTTCCGCATGCGGAGCCACAGCTATGTGCGGGCCATTGAGAAAGGCTGCTCCCAGGACGACGAGTGCGTGTCCC
TGAGGTCGTCCTCGCCGCCGCGCACCACCACCACCGTTAGGACCATCCAGAGCAGCACGGACTTGTGTGCGAGACAGAGCCACTCTTTCT
ATCCTGGCTGTTAGGAATATCAGCAAAGAAGTAGCTAAAAAGGCTGTTGATGAAGTTTTTGAATCTTGTTTCAATGACCATGAACCTTTT
GGAAGGATCCCACATAACAAGACTTATGCAAGATATGCTCACAGAGACTTTGAAAACCGTGATCGGTATTATTCAAATATATGAGCACAA
TGACATTTTTATATTACAGAGCTTCCATCATCATGAAGAAAAAAAAATTTGGTTCTCAAGTGAACAAACATATAAAATGTAAACAATCCC
TACAATCCAGATAAAACAGAGAAGACTGTGATTCTAGCATATTATCAGAAAAAGTAACTATGGCAAAAAATGAAACTGCTTTAAACTCCA
AGGCAGAAATTGTATCTTTATAGCTAACCATTTAGTAAATAAATACATTACATTTTTGTATTTTAGTCATTTGTTTTTATTACATGTGAT
TATTTTAAAATTTGATTATGAAACCTGTGAAGTGTGCTCTTCCATGATGTTGATAGGTGACCACTGTTGGTATTTACATTAAATGTAAAG

>23149_23149_1_DLGAP1-XRCC6BP1_DLGAP1_chr18_3729135_ENST00000515196_XRCC6BP1_chr12_58350470_ENST00000300145_length(amino acids)=544AA_BP=
MKGLSGSRSHHHGVTCDSACDSLSHHSDRKPYLLSPVEHHPADHPYYTQRNSFQAECVGPFSDPLASSTFPRRHYTSQQELKDECALVPR
TLATKANRIPANLLDQFERQLPLSRDGYHTLQYKRTAVEHRSDSPGRIRHLVHSVQKLFTKSHSLEGPSKGSVNGGKASPDEAQAARYGK
RSKSKERRAEPKARPSTSPGWWSSDDNLDGDMCIYHAPSGVMTMGRCPDRSASQYFLEAYNTISEQAVKASRSNNDVKCSTCANLPVSLD
TPLLKKSAWSSTLTVSRAREVYQKASVNMDQAMVKSESCQQERSCQYLQVPQDEWTGYTPRGKDDEIPCRRMRSGSYIKAMGDEDSGDSD
TSPKPSPKVAARRESYLKATQPSLTELTTLKISNEHSPKLQIRSHSYLRAVSEVSINRSLDSLDPAGLLTSPKFRSRNESYMRAMSTISQ
VSEMEVNGQFESVCESVFSELESQAVEALDLPMPGCFRMRSHSYVRAIEKGCSQDDECVSLRSSSPPRTTTTVRTIQSSTDLCARQSHSF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DLGAP1-XRCC6BP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000315677-713650_661530.3333333333334978.0DYL2
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000315677-713672_683530.3333333333334978.0DYL2
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000400145-49650_661228.33333333333334628.0DYL2
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000400145-49672_683228.33333333333334628.0DYL2
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000400147-410650_661228.33333333333334676.0DYL2
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000400147-410672_683228.33333333333334676.0DYL2
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000400155-410650_661236.33333333333334684.0DYL2
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000400155-410672_683236.33333333333334684.0DYL2
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000515196-611650_661530.3333333333334930.0DYL2
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000515196-611672_683530.3333333333334930.0DYL2
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000534970-410650_661242.33333333333334662.0DYL2
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000534970-410672_683242.33333333333334662.0DYL2
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000539435-411650_661228.33333333333334686.0DYL2
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000539435-411672_683228.33333333333334686.0DYL2
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000581527-712650_661530.3333333333334930.0DYL2
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000581527-712672_683530.3333333333334930.0DYL2
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000581699-410650_661236.33333333333334684.0DYL2
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000581699-410672_683236.33333333333334684.0DYL2
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000584874-410650_661530.3333333333334978.0DYL2
HgeneDLGAP1chr18:3729135chr12:58350470ENST00000584874-410672_683530.3333333333334978.0DYL2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DLGAP1-XRCC6BP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DLGAP1-XRCC6BP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource