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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DLGAP4-TMEM189 (FusionGDB2 ID:23181)

Fusion Gene Summary for DLGAP4-TMEM189

check button Fusion gene summary
Fusion gene informationFusion gene name: DLGAP4-TMEM189
Fusion gene ID: 23181
HgeneTgene
Gene symbol

DLGAP4

TMEM189

Gene ID

22839

387521

Gene nameDLG associated protein 4transmembrane protein 189
SynonymsDAP-4|DAP4|DLP4|SAPAP-4|SAPAP4CarF|KUA
Cytomap

20q11.23

20q13.13

Type of geneprotein-codingprotein-coding
Descriptiondisks large-associated protein 4PSD-95/SAP90-binding protein 4SAP90/PSD-95-associated protein 4discs large homolog associated protein 4transmembrane protein 189
Modification date2020031320200313
UniProtAcc

Q9Y2H0

.
Ensembl transtripts involved in fusion geneENST00000475894, ENST00000340491, 
ENST00000339266, ENST00000373907, 
ENST00000373913, ENST00000401952, 
ENST00000371650, ENST00000371652, 
ENST00000371656, ENST00000557021, 
Fusion gene scores* DoF score18 X 16 X 9=25924 X 3 X 4=48
# samples 234
** MAII scorelog2(23/2592*10)=-3.49435995194025
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DLGAP4 [Title/Abstract] AND TMEM189 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDLGAP4(35091002)-TMEM189(48747484), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTMEM189

GO:0008611

ether lipid biosynthetic process

31604315


check buttonFusion gene breakpoints across DLGAP4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMEM189 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-CW-6087-01ADLGAP4chr20

35089913

+TMEM189chr20

48747484

-
ChimerDB4KIRCTCGA-CW-6087-01ADLGAP4chr20

35091002

+TMEM189chr20

48747484

-


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Fusion Gene ORF analysis for DLGAP4-TMEM189

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000475894ENST00000371650DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
3UTR-3CDSENST00000475894ENST00000371652DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
3UTR-3CDSENST00000475894ENST00000371656DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
3UTR-3CDSENST00000475894ENST00000557021DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
In-frameENST00000340491ENST00000371650DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
In-frameENST00000340491ENST00000371652DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
In-frameENST00000340491ENST00000371656DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
In-frameENST00000340491ENST00000557021DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
intron-3CDSENST00000339266ENST00000371650DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
intron-3CDSENST00000339266ENST00000371650DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
intron-3CDSENST00000339266ENST00000371652DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
intron-3CDSENST00000339266ENST00000371652DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
intron-3CDSENST00000339266ENST00000371656DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
intron-3CDSENST00000339266ENST00000371656DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
intron-3CDSENST00000339266ENST00000557021DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
intron-3CDSENST00000339266ENST00000557021DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
intron-3CDSENST00000340491ENST00000371650DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
intron-3CDSENST00000340491ENST00000371652DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
intron-3CDSENST00000340491ENST00000371656DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
intron-3CDSENST00000340491ENST00000557021DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
intron-3CDSENST00000373907ENST00000371650DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
intron-3CDSENST00000373907ENST00000371650DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
intron-3CDSENST00000373907ENST00000371652DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
intron-3CDSENST00000373907ENST00000371652DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
intron-3CDSENST00000373907ENST00000371656DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
intron-3CDSENST00000373907ENST00000371656DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
intron-3CDSENST00000373907ENST00000557021DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
intron-3CDSENST00000373907ENST00000557021DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
intron-3CDSENST00000373913ENST00000371650DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
intron-3CDSENST00000373913ENST00000371650DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
intron-3CDSENST00000373913ENST00000371652DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
intron-3CDSENST00000373913ENST00000371652DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
intron-3CDSENST00000373913ENST00000371656DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
intron-3CDSENST00000373913ENST00000371656DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
intron-3CDSENST00000373913ENST00000557021DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
intron-3CDSENST00000373913ENST00000557021DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
intron-3CDSENST00000401952ENST00000371650DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
intron-3CDSENST00000401952ENST00000371650DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
intron-3CDSENST00000401952ENST00000371652DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
intron-3CDSENST00000401952ENST00000371652DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
intron-3CDSENST00000401952ENST00000371656DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
intron-3CDSENST00000401952ENST00000371656DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
intron-3CDSENST00000401952ENST00000557021DLGAP4chr20

35089913

+TMEM189chr20

48747484

-
intron-3CDSENST00000401952ENST00000557021DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
intron-3CDSENST00000475894ENST00000371650DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
intron-3CDSENST00000475894ENST00000371652DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
intron-3CDSENST00000475894ENST00000371656DLGAP4chr20

35091002

+TMEM189chr20

48747484

-
intron-3CDSENST00000475894ENST00000557021DLGAP4chr20

35091002

+TMEM189chr20

48747484

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000340491DLGAP4chr2035091002+ENST00000557021TMEM189chr2048747484-33678537501724324
ENST00000340491DLGAP4chr2035091002+ENST00000371650TMEM189chr2048747484-273785335805256
ENST00000340491DLGAP4chr2035091002+ENST00000371652TMEM189chr2048747484-271385335805256
ENST00000340491DLGAP4chr2035091002+ENST00000371656TMEM189chr2048747484-271385335805256

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000340491ENST00000557021DLGAP4chr2035091002+TMEM189chr2048747484-0.0062663470.9937337
ENST00000340491ENST00000371650DLGAP4chr2035091002+TMEM189chr2048747484-0.342808250.6571917
ENST00000340491ENST00000371652DLGAP4chr2035091002+TMEM189chr2048747484-0.325240940.6747591
ENST00000340491ENST00000371656DLGAP4chr2035091002+TMEM189chr2048747484-0.325240940.6747591

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Fusion Genomic Features for DLGAP4-TMEM189


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DLGAP4-TMEM189


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:35091002/chr20:48747484)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DLGAP4

Q9Y2H0

.
FUNCTION: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMEM189chr20:35091002chr20:48747484ENST0000037165216186_19080271.0MotifHistidine box-1
TgeneTMEM189chr20:35091002chr20:48747484ENST0000037165216213_21780271.0MotifHistidine box-2
TgeneTMEM189chr20:35091002chr20:48747484ENST0000037165216161_18180271.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDLGAP4chr20:35091002chr20:48747484ENST00000339266+111267_2740993.0Compositional biasNote=Poly-Pro
HgeneDLGAP4chr20:35091002chr20:48747484ENST00000340491+17267_27410454.0Compositional biasNote=Poly-Pro
HgeneDLGAP4chr20:35091002chr20:48747484ENST00000373907+112267_2740993.0Compositional biasNote=Poly-Pro
HgeneDLGAP4chr20:35091002chr20:48747484ENST00000373913+113267_2740990.0Compositional biasNote=Poly-Pro
HgeneDLGAP4chr20:35091002chr20:48747484ENST00000401952+112267_2740990.0Compositional biasNote=Poly-Pro
TgeneTMEM189chr20:35091002chr20:48747484ENST000003716521647_6780271.0TransmembraneHelical
TgeneTMEM189chr20:35091002chr20:48747484ENST000003716521674_9480271.0TransmembraneHelical


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Fusion Gene Sequence for DLGAP4-TMEM189


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>23181_23181_1_DLGAP4-TMEM189_DLGAP4_chr20_35091002_ENST00000340491_TMEM189_chr20_48747484_ENST00000371650_length(transcript)=2737nt_BP=853nt
GTCCGCCCGCCCGCCCGCCCGCCCGCGCTTCCGTCCTGTCCAGCCGCCAGTCCTCCAGCCCGTGTCCCCGCTCCGCCCGCTTTGTCTCTC
CCCGGCTCGCTGTCTCTTTGTCTCTGCCCTCGCGCTCCTCCGCAGCCCCTCCCTCGCTCCCCATCTCGGGTCCCCTTCTCAGAGCGCTCT
TCAGCCCTCAGAGCCGCCCTTTCTGGGCGACCCCACTCTTCGGGACTCCCCCTCAGAGCGCCCCCAGATCTTTTGGGGTTCCCCTTGAGA
ACACCTTCCACTCTCCCCAAGGGCTCCCCGTGAGTTTCTTGCACATCCTTTGGGGGTTCTGCACCCCAAGTCGCTGGGGTCTCGCCTCCT
CTGAACCCCCATTGCCCCTGGGCTTTCCCTCTTCTGGGTGTTCCCCATATCCACTGGGAGCTCCTAGGTCCCAAGTTGGGGTCTTTCTCC
TTGGGACCCCCCAATATGTCCTCAGCTCCCTGACTTCAGGAGCTCCTCTCTGCTTTCCCCTGGTTTGTCCCCTGTCGCTGTCTCTCCTTG
TTCTCTCTCAGGTCTCCGAGCACCCCCACTTCTCGGGATCGGGGTCCCCTGCTTTGCTCTCCCTGCCCCTCTGTGCCCCCACATCTGTCT
CGGTGGTCTCGCCACTCTGTGCCTCTTGCGCTGAAGGCCCCCCTTTGAGCCTGCTTCTTTGCCTGGGGCCCTTGGCCCCCCCTTGCTTTT
TCAGCCCTAGCCCCCTGTCTCCCCTTCTCTCTGCTCCTTGTCTCCCTCTCCCTTTTTCTGTCTTTGCCGGGTCTCTGGGTCTCTGACCCC
CATCCGGCCCTCATGGCTTTGTGTCTGGAGCTCTTGAAGCAATTTGCAGGGGCTCTCATTGCTGACTTCTTGTCTGGCCTGGTACACTGG
GGTGCTGACACATGGGGCTCTGTGGAGCTGCCCATTGCTTTCATCCGACCCTTCCGGGAGCACCACATTGACCCGACAGCTATCACACGG
CACGACTTCATCGAGACCAACGGGGACAACTGCCTGGTGACACTGCTGCCGCTGCTAAACATGGCCTACAAGTTCCGCACCCACAGCCCT
GAAGCCCTGGAGCAGCTATACCCCTGGGAGTGCTTCGTCTTCTGCCTGATCATCTTCGGCACCTTCACCAACCAGATCCACAAGTGGTCG
CACACGTACTTTGGGCTGCCACGCTGGGTCACCCTCCTGCAGGACTGGCATGTCATCCTGCCACGTAAACACCATCGCATCCACCACGTC
TCACCCCACGAGACCTACTTCTGCATCACCACAGGCTGGCTCAACTACCCTCTGGAGAAGATAGGCTTCTGGCGACGCCTGGAGGACCTC
ATCCAGGGCCTGACGGGCGAGAAGCCTCGGGCAGATGACATGAAATGGGCCCAGAAGATCAAATAACTTCTCCGAGCCTGCTACCTGGTT
GCCAACCTTCCCTAGCCCCCAAACCGAAGCCATCTGCCAAATTCCAGCCTCTTTGAGCTGGCCCCTCCAGATGGAGAGGACATCTCCTGG
GCTGGGCCCAGGTACCCCAGCCCACCCCTCATGACACAGAATACTTGAGCCACTGATTTTTCATTTCTTTTTTTTTTTTTTCCTCGGCCC
CTCCTCAGCCACCTGAGTTGCTCTATCTGCAAGCCTGACTCTGCCAGCCTCCCCTGGTAGAGAGGAGGTTTACCCACTCCCTGCACGCCT
GCCGTCCCTGCCCCGCTGGGCAGCCCTTCAGTGTGGCTGGCGTTGGGGCCAGTGAGTTGCCTCTTTCCCTCCTTGTCTGGCCCCAGTGGT
CTGGGGAGCCCCCAGGCACACCTAAGCGTCGTGGAGCATTGTTCTGCCACAGCCCTGCATACTGACCCCGGGAGGCTGGGCAGGTGGACA
GCCCCAGCCACCACCTTCAGCCTAGCCTGTCCCCCAAGGATGGTGAAGCTCAGCAGGGGTCTGAGGGTAGCCGGCCAGAAGAGGCTGGAA
CCTCCTGCTCAAGTCTAGACCCCTACTTCTCTGCTGCCCCCACCCTGCCAGAGCTGATGTTTCCAATACCAAGATGTCTTCACAGGGCAC
AGCCCCTGCAGAGCATCTTGGTCATTTGGAAGAGGACACGGTATCCCCTCTGGCCAGAGTATGTCAGAGAAGGAAGAGTAGGGCTTTTTT
GTTTTGTTTTTTTTTAAAGGTGCTTGCTTGTTTAATGTAAATAATAGAAAGCCTTAATATCTTTTCTGTAACACGGAGTAATATTTTAAT
GTCATGTTTTGGATGTACATAATATATTTATAACAAAGCAGCAAGAGTCTACTTAACCTTGGCTGCCTCGTGGTGTTTCCTGGCTGGGTG
GGGTGGGGGGTATCAAGGAGCCTGGGACGTGAGGCCCCACTCTCGCCCCATTCCCAGCTCCCCCCAACCCTGGCCTCAGGATGAGAGCTG
TCACCTGAGACAGTGAATTAATGTTGACATCTGCTCCAAAGCCTTTTGGAGGGGATTGGGTGAGGACAGTGGTCTTTCCTGTTGATCATG
ATGATAAAGTAATGATGGCTGATCCCTATTTGTGACTTCCTTCAGCAAATATTCACTGGCACCTGGTGTGTGCCAGGCTCTGTCCTGTAC
ACAGGTACAGCGGTGAAAGAACCAACAAAGACCTATCCTGGTGGAGCTGACCTCCTGGGAAAAGAGTCAATAAACAAATAAATGCACATG

>23181_23181_1_DLGAP4-TMEM189_DLGAP4_chr20_35091002_ENST00000340491_TMEM189_chr20_48747484_ENST00000371650_length(amino acids)=256AA_BP=
MSSRQSSSPCPRSARFVSPRLAVSLSLPSRSSAAPPSLPISGPLLRALFSPQSRPFWATPLFGTPPQSAPRSFGVPLENTFHSPQGLPVS
FLHILWGFCTPSRWGLASSEPPLPLGFPSSGCSPYPLGAPRSQVGVFLLGTPQYVLSSLTSGAPLCFPLVCPLSLSLLVLSQVSEHPHFS

--------------------------------------------------------------
>23181_23181_2_DLGAP4-TMEM189_DLGAP4_chr20_35091002_ENST00000340491_TMEM189_chr20_48747484_ENST00000371652_length(transcript)=2713nt_BP=853nt
GTCCGCCCGCCCGCCCGCCCGCCCGCGCTTCCGTCCTGTCCAGCCGCCAGTCCTCCAGCCCGTGTCCCCGCTCCGCCCGCTTTGTCTCTC
CCCGGCTCGCTGTCTCTTTGTCTCTGCCCTCGCGCTCCTCCGCAGCCCCTCCCTCGCTCCCCATCTCGGGTCCCCTTCTCAGAGCGCTCT
TCAGCCCTCAGAGCCGCCCTTTCTGGGCGACCCCACTCTTCGGGACTCCCCCTCAGAGCGCCCCCAGATCTTTTGGGGTTCCCCTTGAGA
ACACCTTCCACTCTCCCCAAGGGCTCCCCGTGAGTTTCTTGCACATCCTTTGGGGGTTCTGCACCCCAAGTCGCTGGGGTCTCGCCTCCT
CTGAACCCCCATTGCCCCTGGGCTTTCCCTCTTCTGGGTGTTCCCCATATCCACTGGGAGCTCCTAGGTCCCAAGTTGGGGTCTTTCTCC
TTGGGACCCCCCAATATGTCCTCAGCTCCCTGACTTCAGGAGCTCCTCTCTGCTTTCCCCTGGTTTGTCCCCTGTCGCTGTCTCTCCTTG
TTCTCTCTCAGGTCTCCGAGCACCCCCACTTCTCGGGATCGGGGTCCCCTGCTTTGCTCTCCCTGCCCCTCTGTGCCCCCACATCTGTCT
CGGTGGTCTCGCCACTCTGTGCCTCTTGCGCTGAAGGCCCCCCTTTGAGCCTGCTTCTTTGCCTGGGGCCCTTGGCCCCCCCTTGCTTTT
TCAGCCCTAGCCCCCTGTCTCCCCTTCTCTCTGCTCCTTGTCTCCCTCTCCCTTTTTCTGTCTTTGCCGGGTCTCTGGGTCTCTGACCCC
CATCCGGCCCTCATGGCTTTGTGTCTGGAGCTCTTGAAGCAATTTGCAGGGGCTCTCATTGCTGACTTCTTGTCTGGCCTGGTACACTGG
GGTGCTGACACATGGGGCTCTGTGGAGCTGCCCATTGTGGGGAAGGCTTTCATCCGACCCTTCCGGGAGCACCACATTGACCCGACAGCT
ATCACACGGCACGACTTCATCGAGACCAACGGGGACAACTGCCTGGTGACACTGCTGCCGCTGCTAAACATGGCCTACAAGTTCCGCACC
CACAGCCCTGAAGCCCTGGAGCAGCTATACCCCTGGGAGTGCTTCGTCTTCTGCCTGATCATCTTCGGCACCTTCACCAACCAGATCCAC
AAGTGGTCGCACACGTACTTTGGGCTGCCACGCTGGGTCACCCTCCTGCAGGACTGGCATGTCATCCTGCCACGTAAACACCATCGCATC
CACCACGTCTCACCCCACGAGACCTACTTCTGCATCACCACAGGCTGGCTCAACTACCCTCTGGAGAAGATAGGCTTCTGGCGACGCCTG
GAGGACCTCATCCAGGGCCTGACGGGCGAGAAGCCTCGGGCAGATGACATGAAATGGGCCCAGAAGATCAAATAACTTCTCCGAGCCTGC
TACCTGGTTGCCAACCTTCCCTAGCCCCCAAACCGAAGCCATCTGCCAAATTCCAGCCTCTTTGAGCTGGCCCCTCCAGATGGAGAGGAC
ATCTCCTGGGCTGGGCCCAGGTACCCCAGCCCACCCCTCATGACACAGAATACTTGAGCCACTGATTTTTCATTTCTTTTTTTTTTTTTT
CCTCGGCCCCTCCTCAGCCACCTGAGTTGCTCTATCTGCAAGCCTGACTCTGCCAGCCTCCCCTGGTAGAGAGGAGGTTTACCCACTCCC
TGCACGCCTGCCGTCCCTGCCCCGCTGGGCAGCCCTTCAGTGTGGCTGGCGTTGGGGCCAGTGAGTTGCCTCTTTCCCTCCTTGTCTGGC
CCCAGTGGTCTGGGGAGCCCCCAGGCACACCTAAGCGTCGTGGAGCATTGTTCTGCCACAGCCCTGCATACTGACCCCGGGAGGCTGGGC
AGGTGGACAGCCCCAGCCACCACCTTCAGCCTAGCCTGTCCCCCAAGGATGGTGAAGCTCAGCAGGGGTCTGAGGGTAGCCGGCCAGAAG
AGGCTGGAACCTCCTGCTCAAGTCTAGACCCCTACTTCTCTGCTGCCCCCACCCTGCCAGAGCTGATGTTTCCAATACCAAGATGTCTTC
ACAGGGCACAGCCCCTGCAGAGCATCTTGGTCATTTGGAAGAGGACACGGTATCCCCTCTGGCCAGAGTATGTCAGAGAAGGAAGAGTAG
GGCTTTTTTGTTTTGTTTTTTTTTAAAGGTGCTTGCTTGTTTAATGTAAATAATAGAAAGCCTTAATATCTTTTCTGTAACACGGAGTAA
TATTTTAATGTCATGTTTTGGATGTACATAATATATTTATAACAAAGCAGCAAGAGTCTACTTAACCTTGGCTGCCTCGTGGTGTTTCCT
GGCTGGGTGGGGTGGGGGGTATCAAGGAGCCTGGGACGTGAGGCCCCACTCTCGCCCCATTCCCAGCTCCCCCCAACCCTGGCCTCAGGA
TGAGAGCTGTCACCTGAGACAGTGAATTAATGTTGACATCTGCTCCAAAGCCTTTTGGAGGGGATTGGGTGAGGACAGTGGTCTTTCCTG
TTGATCATGATGATAAAGTAATGATGGCTGATCCCTATTTGTGACTTCCTTCAGCAAATATTCACTGGCACCTGGTGTGTGCCAGGCTCT
GTCCTGTACACAGGTACAGCGGTGAAAGAACCAACAAAGACCTATCCTGGTGGAGCTGACCTCCTGGGAAAAGAGTCAATAAACAAATAA

>23181_23181_2_DLGAP4-TMEM189_DLGAP4_chr20_35091002_ENST00000340491_TMEM189_chr20_48747484_ENST00000371652_length(amino acids)=256AA_BP=
MSSRQSSSPCPRSARFVSPRLAVSLSLPSRSSAAPPSLPISGPLLRALFSPQSRPFWATPLFGTPPQSAPRSFGVPLENTFHSPQGLPVS
FLHILWGFCTPSRWGLASSEPPLPLGFPSSGCSPYPLGAPRSQVGVFLLGTPQYVLSSLTSGAPLCFPLVCPLSLSLLVLSQVSEHPHFS

--------------------------------------------------------------
>23181_23181_3_DLGAP4-TMEM189_DLGAP4_chr20_35091002_ENST00000340491_TMEM189_chr20_48747484_ENST00000371656_length(transcript)=2713nt_BP=853nt
GTCCGCCCGCCCGCCCGCCCGCCCGCGCTTCCGTCCTGTCCAGCCGCCAGTCCTCCAGCCCGTGTCCCCGCTCCGCCCGCTTTGTCTCTC
CCCGGCTCGCTGTCTCTTTGTCTCTGCCCTCGCGCTCCTCCGCAGCCCCTCCCTCGCTCCCCATCTCGGGTCCCCTTCTCAGAGCGCTCT
TCAGCCCTCAGAGCCGCCCTTTCTGGGCGACCCCACTCTTCGGGACTCCCCCTCAGAGCGCCCCCAGATCTTTTGGGGTTCCCCTTGAGA
ACACCTTCCACTCTCCCCAAGGGCTCCCCGTGAGTTTCTTGCACATCCTTTGGGGGTTCTGCACCCCAAGTCGCTGGGGTCTCGCCTCCT
CTGAACCCCCATTGCCCCTGGGCTTTCCCTCTTCTGGGTGTTCCCCATATCCACTGGGAGCTCCTAGGTCCCAAGTTGGGGTCTTTCTCC
TTGGGACCCCCCAATATGTCCTCAGCTCCCTGACTTCAGGAGCTCCTCTCTGCTTTCCCCTGGTTTGTCCCCTGTCGCTGTCTCTCCTTG
TTCTCTCTCAGGTCTCCGAGCACCCCCACTTCTCGGGATCGGGGTCCCCTGCTTTGCTCTCCCTGCCCCTCTGTGCCCCCACATCTGTCT
CGGTGGTCTCGCCACTCTGTGCCTCTTGCGCTGAAGGCCCCCCTTTGAGCCTGCTTCTTTGCCTGGGGCCCTTGGCCCCCCCTTGCTTTT
TCAGCCCTAGCCCCCTGTCTCCCCTTCTCTCTGCTCCTTGTCTCCCTCTCCCTTTTTCTGTCTTTGCCGGGTCTCTGGGTCTCTGACCCC
CATCCGGCCCTCATGGCTTTGTGTCTGGAGCTCTTGAAGCAATTTGCAGGGGCTCTCATTGCTGACTTCTTGTCTGGCCTGGTACACTGG
GGTGCTGACACATGGGGCTCTGTGGAGCTGCCCATTGTGGGGAAGGCTTTCATCCGACCCTTCCGGGAGCACCACATTGACCCGACAGCT
ATCACACGGCACGACTTCATCGAGACCAACGGGGACAACTGCCTGGTGACACTGCTGCCGCTGCTAAACATGGCCTACAAGTTCCGCACC
CACAGCCCTGAAGCCCTGGAGCAGCTATACCCCTGGGAGTGCTTCGTCTTCTGCCTGATCATCTTCGGCACCTTCACCAACCAGATCCAC
AAGTGGTCGCACACGTACTTTGGGCTGCCACGCTGGGTCACCCTCCTGCAGGACTGGCATGTCATCCTGCCACGTAAACACCATCGCATC
CACCACGTCTCACCCCACGAGACCTACTTCTGCATCACCACAGGCTGGCTCAACTACCCTCTGGAGAAGATAGGCTTCTGGCGACGCCTG
GAGGACCTCATCCAGGGCCTGACGGGCGAGAAGCCTCGGGCAGATGACATGAAATGGGCCCAGAAGATCAAATAACTTCTCCGAGCCTGC
TACCTGGTTGCCAACCTTCCCTAGCCCCCAAACCGAAGCCATCTGCCAAATTCCAGCCTCTTTGAGCTGGCCCCTCCAGATGGAGAGGAC
ATCTCCTGGGCTGGGCCCAGGTACCCCAGCCCACCCCTCATGACACAGAATACTTGAGCCACTGATTTTTCATTTCTTTTTTTTTTTTTT
CCTCGGCCCCTCCTCAGCCACCTGAGTTGCTCTATCTGCAAGCCTGACTCTGCCAGCCTCCCCTGGTAGAGAGGAGGTTTACCCACTCCC
TGCACGCCTGCCGTCCCTGCCCCGCTGGGCAGCCCTTCAGTGTGGCTGGCGTTGGGGCCAGTGAGTTGCCTCTTTCCCTCCTTGTCTGGC
CCCAGTGGTCTGGGGAGCCCCCAGGCACACCTAAGCGTCGTGGAGCATTGTTCTGCCACAGCCCTGCATACTGACCCCGGGAGGCTGGGC
AGGTGGACAGCCCCAGCCACCACCTTCAGCCTAGCCTGTCCCCCAAGGATGGTGAAGCTCAGCAGGGGTCTGAGGGTAGCCGGCCAGAAG
AGGCTGGAACCTCCTGCTCAAGTCTAGACCCCTACTTCTCTGCTGCCCCCACCCTGCCAGAGCTGATGTTTCCAATACCAAGATGTCTTC
ACAGGGCACAGCCCCTGCAGAGCATCTTGGTCATTTGGAAGAGGACACGGTATCCCCTCTGGCCAGAGTATGTCAGAGAAGGAAGAGTAG
GGCTTTTTTGTTTTGTTTTTTTTTAAAGGTGCTTGCTTGTTTAATGTAAATAATAGAAAGCCTTAATATCTTTTCTGTAACACGGAGTAA
TATTTTAATGTCATGTTTTGGATGTACATAATATATTTATAACAAAGCAGCAAGAGTCTACTTAACCTTGGCTGCCTCGTGGTGTTTCCT
GGCTGGGTGGGGTGGGGGGTATCAAGGAGCCTGGGACGTGAGGCCCCACTCTCGCCCCATTCCCAGCTCCCCCCAACCCTGGCCTCAGGA
TGAGAGCTGTCACCTGAGACAGTGAATTAATGTTGACATCTGCTCCAAAGCCTTTTGGAGGGGATTGGGTGAGGACAGTGGTCTTTCCTG
TTGATCATGATGATAAAGTAATGATGGCTGATCCCTATTTGTGACTTCCTTCAGCAAATATTCACTGGCACCTGGTGTGTGCCAGGCTCT
GTCCTGTACACAGGTACAGCGGTGAAAGAACCAACAAAGACCTATCCTGGTGGAGCTGACCTCCTGGGAAAAGAGTCAATAAACAAATAA

>23181_23181_3_DLGAP4-TMEM189_DLGAP4_chr20_35091002_ENST00000340491_TMEM189_chr20_48747484_ENST00000371656_length(amino acids)=256AA_BP=
MSSRQSSSPCPRSARFVSPRLAVSLSLPSRSSAAPPSLPISGPLLRALFSPQSRPFWATPLFGTPPQSAPRSFGVPLENTFHSPQGLPVS
FLHILWGFCTPSRWGLASSEPPLPLGFPSSGCSPYPLGAPRSQVGVFLLGTPQYVLSSLTSGAPLCFPLVCPLSLSLLVLSQVSEHPHFS

--------------------------------------------------------------
>23181_23181_4_DLGAP4-TMEM189_DLGAP4_chr20_35091002_ENST00000340491_TMEM189_chr20_48747484_ENST00000557021_length(transcript)=3367nt_BP=853nt
GTCCGCCCGCCCGCCCGCCCGCCCGCGCTTCCGTCCTGTCCAGCCGCCAGTCCTCCAGCCCGTGTCCCCGCTCCGCCCGCTTTGTCTCTC
CCCGGCTCGCTGTCTCTTTGTCTCTGCCCTCGCGCTCCTCCGCAGCCCCTCCCTCGCTCCCCATCTCGGGTCCCCTTCTCAGAGCGCTCT
TCAGCCCTCAGAGCCGCCCTTTCTGGGCGACCCCACTCTTCGGGACTCCCCCTCAGAGCGCCCCCAGATCTTTTGGGGTTCCCCTTGAGA
ACACCTTCCACTCTCCCCAAGGGCTCCCCGTGAGTTTCTTGCACATCCTTTGGGGGTTCTGCACCCCAAGTCGCTGGGGTCTCGCCTCCT
CTGAACCCCCATTGCCCCTGGGCTTTCCCTCTTCTGGGTGTTCCCCATATCCACTGGGAGCTCCTAGGTCCCAAGTTGGGGTCTTTCTCC
TTGGGACCCCCCAATATGTCCTCAGCTCCCTGACTTCAGGAGCTCCTCTCTGCTTTCCCCTGGTTTGTCCCCTGTCGCTGTCTCTCCTTG
TTCTCTCTCAGGTCTCCGAGCACCCCCACTTCTCGGGATCGGGGTCCCCTGCTTTGCTCTCCCTGCCCCTCTGTGCCCCCACATCTGTCT
CGGTGGTCTCGCCACTCTGTGCCTCTTGCGCTGAAGGCCCCCCTTTGAGCCTGCTTCTTTGCCTGGGGCCCTTGGCCCCCCCTTGCTTTT
TCAGCCCTAGCCCCCTGTCTCCCCTTCTCTCTGCTCCTTGTCTCCCTCTCCCTTTTTCTGTCTTTGCCGGGTCTCTGGGTCTCTGACCCC
CATCCGGCCCTCATGGCTTTGTGTCTGGAGCTCTTGAAGCAATTTGCAGGGGCTCTCATTGCTGACTTCTTGTCTGGCCTGGTACACTGG
GGTGCTGACACATGGGGCTCTGTGGAGCTGCCCATTGTGGGGAAGGCTTTCATCCGACCCTTCCGGGAGCACCACATTGACCCGACAGCT
ATCACACGGCACGACTTCATCGAGACCAACGGGGACAACTGCCTGGTGACACTGCTGCCGCTGCTAAACATGGCCTACAAGTTCCGCACC
CACAGCCCTGAAGCCCTGGAGCAGCTATACCCCTGGGAGTGCTTCGTCTTCTGCCTGATCATCTTCGGCACCTTCACCAACCAGATCCAC
AAGTGGTCGCACACGTACTTTGGGCTGCCACGCTGGGTCACCCTCCTGCAGGACTGGCATGTCATCCTGCCACGTAAACACCATCGCATC
CACCACGTCTCACCCCACGAGACCTACTTCTGCATCACCACAGGAGTAAAAGTCCCTCGCAATTTCCGACTGTTGGAAGAACTCGAAGAA
GGCCAGAAAGGAGTAGGAGATGGCACAGTTAGCTGGGGTCTAGAAGATGACGAAGACATGACACTTACAAGATGGACAGGGATGATAATT
GGGCCTCCAAGAACAATTTATGAAAACCGAATATACAGCCTTAAAATAGAATGTGGACCTAAATACCCAGAAGCACCCCCCTTTGTAAGA
TTTGTAACAAAAATTAATATGAATGGAGTAAATAGTTCTAATGGAGTGGTGGACCCAAGAGCCATATCAGTGCTAGCAAAATGGCAGAAT
TCATATAGCATCAAAGTTGTCCTGCAAGAGCTTCGGCGCCTAATGATGTCTAAAGAAAATATGAAACTCCCTCAGCCGCCCGAAGGACAG
TGTTACAGCAATTAATCAAAAAGAAAAACCACAGGCCCTTCCCCTTCCCCCCAATTCGATTTAATCAGTCTTCATTTTCCACAGTAGTAA
ATTTTCTAGATACGTCTTGTAGACCTCAAAGTACCGGAAAGGAAGCTCCCATTCAAAGGAAATTTATCTTAAGATACTGTAAATGATACT
AATTTTTTGTCCATTTGAAATATATAAGTTGTGCTATAACAAATCATCCTGTCAAGTGTAACCACTGTCCACGTAGTTGAACTTCTGGGA
TCAAGAAAGTCTATTTAAATTGATTCCCATCATAACTGGTGGGGCACATCTAACTCAACTGTGAAAAGACACATCACACAATCACCTTGC
TGCTGATTACACGGCCTGGGGTCTCTGCCTTCTCCCCTTACCCTCCCGCCTCCCACCCTCCCTGCAACAACAGCCCTCTAGCCTGGGGGG
CTTGTTAGAGTAGATGTGAAGGTTTCAGGTCGCAGCCTGTGGGACTACTGCTAGGTGTGTGGGGTGTTTCGCCTGCACCCCTGGTTTCTT
TAAGTCTTAAGTGATGCCCCTTCCAAACCATCATCCTGTCCCCACGCTCCTCCACTCCCGCCCTTGGCCGAAGCATAGATTGTAACCCCT
CCACTCCCCTCTGAGATTGGCCTTCGGTGAGGAATTCAGGGCTTTCCCCATATCTTCTCTCCCCCACCTTTATCGAGGGGTGCTGCTTTT
TCTCCCTCCTCCTCAAGTTCCTTTTTGCACCGTCACCACCCAACACCTTCCATGACACTTCCTTGCTTTGGCCAGAAGCCATCAGGTAAG
GTTGGAAAGAGCCTCTGACCTCCCTTGTTTAGTTTTGGAACCATACTCACTCACTCTCCACCAGCCTGGGAAATGAATATTGGGTCCTCA
GCCCTGCCACCCTCTGCTGTCATCAGCTGATGCATTGTTTTTAGCTCAGGTTTTGATAAGGTGAAAAGAATAGTCACCAGGGTTACTCAG
ACCTGCCAGCTCTCGGAGTCCTTGGTGGTTGAACTTGGAGAAAGACCGCATGAAGATACTTGTAAGCACACATGATCCCTCTGAATTGTT
TTACTTTCCTGTAACTGCTTTTGCTTTTAAAAATTGAAGAAGTTTTAAACAGGGCTTTCATTTGGTCATCCTTGCAATCCATTGGGGTCT
AGTTTGGAATCTGACAACTGGAACAAAAAGAACCTTGAATCCGGTGCATGCCTTGGTTTTGGTGCTGCTGCTGCTTCCCAAGATCCTCAG
CAGGGATTAAGAAGGAACCCGGTGTGCACAGCAGATCCCCGAAATTGGTGGGCTTGACCTCCTGGCAAATTGCTGCGTCTTTCCACTTGC
TGTTCAGGACCACTAAATGCTGAAATGTGGATGCATACCGAAATAAAAGCAATTCATTGTGTACTAAAGGTTTTTTTTTTTTTTTTAATT
TAGTATTTGTGTAAAACCACCTTTTGAAGCAGCAACTATCAAGTCTGAAAAGCAATTGATGTTTCCATTAATCTTTTTCTGGGGGGAAAA
CCTTAGTTCTAAGGATTTAACATCCTGTAAGTGAAGTTTAACATAACAGTATTCCATAAGCAGCCTTTTTATTGTCAGACCATTGCCTGA

>23181_23181_4_DLGAP4-TMEM189_DLGAP4_chr20_35091002_ENST00000340491_TMEM189_chr20_48747484_ENST00000557021_length(amino acids)=324AA_BP=28
MLLVSLSLFLSLPGLWVSDPHPALMALCLELLKQFAGALIADFLSGLVHWGADTWGSVELPIVGKAFIRPFREHHIDPTAITRHDFIETN
GDNCLVTLLPLLNMAYKFRTHSPEALEQLYPWECFVFCLIIFGTFTNQIHKWSHTYFGLPRWVTLLQDWHVILPRKHHRIHHVSPHETYF
CITTGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPFVRFVTKINMNGV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DLGAP4-TMEM189


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DLGAP4-TMEM189


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DLGAP4-TMEM189


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource