FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:DMGDH-NMNAT2 (FusionGDB2 ID:23250)

Fusion Gene Summary for DMGDH-NMNAT2

check button Fusion gene summary
Fusion gene informationFusion gene name: DMGDH-NMNAT2
Fusion gene ID: 23250
HgeneTgene
Gene symbol

DMGDH

NMNAT2

Gene ID

29958

23057

Gene namedimethylglycine dehydrogenasenicotinamide nucleotide adenylyltransferase 2
SynonymsDMGDHD|ME2GLYDHC1orf15|PNAT2
Cytomap

5q14.1

1q25.3

Type of geneprotein-codingprotein-coding
Descriptiondimethylglycine dehydrogenase, mitochondrialnicotinamide/nicotinic acid mononucleotide adenylyltransferase 2NMN adenylyltransferase 2NMN/NaMN adenylyltransferase 2NaMN adenylyltransferase 2nicotinamide mononucleotide adenylyltransferase 2nicotinate-nucleotide adenylyltransferase 2pyridine nuc
Modification date2020031320200313
UniProtAcc.

Q9BZQ4

Ensembl transtripts involved in fusion geneENST00000255189, ENST00000380311, 
ENST00000520388, ENST00000540686, 
ENST00000473046, ENST00000287713, 
ENST00000294868, 
Fusion gene scores* DoF score1 X 2 X 1=28 X 8 X 5=320
# samples 211
** MAII scorelog2(2/2*10)=3.32192809488736log2(11/320*10)=-1.5405683813627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DMGDH [Title/Abstract] AND NMNAT2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDMGDH(78301096)-NMNAT2(183230438), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DMGDH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NMNAT2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-CW-5589-01ADMGDHchr5

78301096

-NMNAT2chr1

183230438

-
ChimerDB4KIRCTCGA-CW-5589DMGDHchr5

78301095

-NMNAT2chr1

183230438

-


Top

Fusion Gene ORF analysis for DMGDH-NMNAT2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000255189ENST00000473046DMGDHchr5

78301096

-NMNAT2chr1

183230438

-
5CDS-intronENST00000255189ENST00000473046DMGDHchr5

78301095

-NMNAT2chr1

183230438

-
In-frameENST00000255189ENST00000287713DMGDHchr5

78301096

-NMNAT2chr1

183230438

-
In-frameENST00000255189ENST00000287713DMGDHchr5

78301095

-NMNAT2chr1

183230438

-
In-frameENST00000255189ENST00000294868DMGDHchr5

78301096

-NMNAT2chr1

183230438

-
In-frameENST00000255189ENST00000294868DMGDHchr5

78301095

-NMNAT2chr1

183230438

-
intron-3CDSENST00000380311ENST00000287713DMGDHchr5

78301096

-NMNAT2chr1

183230438

-
intron-3CDSENST00000380311ENST00000287713DMGDHchr5

78301095

-NMNAT2chr1

183230438

-
intron-3CDSENST00000380311ENST00000294868DMGDHchr5

78301096

-NMNAT2chr1

183230438

-
intron-3CDSENST00000380311ENST00000294868DMGDHchr5

78301095

-NMNAT2chr1

183230438

-
intron-3CDSENST00000520388ENST00000287713DMGDHchr5

78301096

-NMNAT2chr1

183230438

-
intron-3CDSENST00000520388ENST00000287713DMGDHchr5

78301095

-NMNAT2chr1

183230438

-
intron-3CDSENST00000520388ENST00000294868DMGDHchr5

78301096

-NMNAT2chr1

183230438

-
intron-3CDSENST00000520388ENST00000294868DMGDHchr5

78301095

-NMNAT2chr1

183230438

-
intron-3CDSENST00000540686ENST00000287713DMGDHchr5

78301096

-NMNAT2chr1

183230438

-
intron-3CDSENST00000540686ENST00000287713DMGDHchr5

78301095

-NMNAT2chr1

183230438

-
intron-3CDSENST00000540686ENST00000294868DMGDHchr5

78301096

-NMNAT2chr1

183230438

-
intron-3CDSENST00000540686ENST00000294868DMGDHchr5

78301095

-NMNAT2chr1

183230438

-
intron-intronENST00000380311ENST00000473046DMGDHchr5

78301096

-NMNAT2chr1

183230438

-
intron-intronENST00000380311ENST00000473046DMGDHchr5

78301095

-NMNAT2chr1

183230438

-
intron-intronENST00000520388ENST00000473046DMGDHchr5

78301096

-NMNAT2chr1

183230438

-
intron-intronENST00000520388ENST00000473046DMGDHchr5

78301095

-NMNAT2chr1

183230438

-
intron-intronENST00000540686ENST00000473046DMGDHchr5

78301096

-NMNAT2chr1

183230438

-
intron-intronENST00000540686ENST00000473046DMGDHchr5

78301095

-NMNAT2chr1

183230438

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000255189DMGDHchr578301096-ENST00000294868NMNAT2chr1183230438-70912414292686885
ENST00000255189DMGDHchr578301096-ENST00000287713NMNAT2chr1183230438-70912414292686885
ENST00000255189DMGDHchr578301095-ENST00000294868NMNAT2chr1183230438-70912414292686885
ENST00000255189DMGDHchr578301095-ENST00000287713NMNAT2chr1183230438-70912414292686885

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000255189ENST00000294868DMGDHchr578301096-NMNAT2chr1183230438-0.0002525320.99974746
ENST00000255189ENST00000287713DMGDHchr578301096-NMNAT2chr1183230438-0.0002525320.99974746
ENST00000255189ENST00000294868DMGDHchr578301095-NMNAT2chr1183230438-0.0002525320.99974746
ENST00000255189ENST00000287713DMGDHchr578301095-NMNAT2chr1183230438-0.0002525320.99974746

Top

Fusion Genomic Features for DMGDH-NMNAT2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for DMGDH-NMNAT2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:78301096/chr1:183230438)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NMNAT2

Q9BZQ4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:16118205, PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency (PubMed:16118205, PubMed:17402747). Cannot use triazofurin monophosphate (TrMP) as substrate (PubMed:16118205, PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (PubMed:16118205, PubMed:17402747). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively (PubMed:16118205, PubMed:17402747). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:16118205, PubMed:17402747). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity). {ECO:0000250|UniProtKB:Q8BNJ3, ECO:0000269|PubMed:16118205, ECO:0000269|PubMed:17402747}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDMGDHchr5:78301095chr1:183230438ENST00000255189-1516397_402795867.0Nucleotide bindingFAD
HgeneDMGDHchr5:78301095chr1:183230438ENST00000255189-151659_60795867.0Nucleotide bindingFAD
HgeneDMGDHchr5:78301095chr1:183230438ENST00000255189-151680_81795867.0Nucleotide bindingFAD
HgeneDMGDHchr5:78301095chr1:183230438ENST00000255189-151687_95795867.0Nucleotide bindingFAD
HgeneDMGDHchr5:78301096chr1:183230438ENST00000255189-1516397_402795867.0Nucleotide bindingFAD
HgeneDMGDHchr5:78301096chr1:183230438ENST00000255189-151659_60795867.0Nucleotide bindingFAD
HgeneDMGDHchr5:78301096chr1:183230438ENST00000255189-151680_81795867.0Nucleotide bindingFAD
HgeneDMGDHchr5:78301096chr1:183230438ENST00000255189-151687_95795867.0Nucleotide bindingFAD
HgeneDMGDHchr5:78301095chr1:183230438ENST00000255189-1516580_582795867.0RegionTetrahydrofolate binding
HgeneDMGDHchr5:78301095chr1:183230438ENST00000255189-1516683_685795867.0RegionTetrahydrofolate binding
HgeneDMGDHchr5:78301096chr1:183230438ENST00000255189-1516580_582795867.0RegionTetrahydrofolate binding
HgeneDMGDHchr5:78301096chr1:183230438ENST00000255189-1516683_685795867.0RegionTetrahydrofolate binding
TgeneNMNAT2chr5:78301095chr1:183230438ENST00000287713711271_274217308.0Nucleotide bindingATP
TgeneNMNAT2chr5:78301095chr1:183230438ENST00000294868711271_274212303.0Nucleotide bindingATP
TgeneNMNAT2chr5:78301096chr1:183230438ENST00000287713711271_274217308.0Nucleotide bindingATP
TgeneNMNAT2chr5:78301096chr1:183230438ENST00000294868711271_274212303.0Nucleotide bindingATP
TgeneNMNAT2chr5:78301095chr1:183230438ENST00000294868711212_213212303.0RegionSubstrate binding
TgeneNMNAT2chr5:78301096chr1:183230438ENST00000294868711212_213212303.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNMNAT2chr5:78301095chr1:183230438ENST0000028771371115_17217308.0Nucleotide bindingATP
TgeneNMNAT2chr5:78301095chr1:183230438ENST00000287713711200_202217308.0Nucleotide bindingATP
TgeneNMNAT2chr5:78301095chr1:183230438ENST0000029486871115_17212303.0Nucleotide bindingATP
TgeneNMNAT2chr5:78301095chr1:183230438ENST00000294868711200_202212303.0Nucleotide bindingATP
TgeneNMNAT2chr5:78301096chr1:183230438ENST0000028771371115_17217308.0Nucleotide bindingATP
TgeneNMNAT2chr5:78301096chr1:183230438ENST00000287713711200_202217308.0Nucleotide bindingATP
TgeneNMNAT2chr5:78301096chr1:183230438ENST0000029486871115_17212303.0Nucleotide bindingATP
TgeneNMNAT2chr5:78301096chr1:183230438ENST00000294868711200_202212303.0Nucleotide bindingATP
TgeneNMNAT2chr5:78301095chr1:183230438ENST00000287713711212_213217308.0RegionSubstrate binding
TgeneNMNAT2chr5:78301095chr1:183230438ENST0000028771371155_57217308.0RegionSubstrate binding
TgeneNMNAT2chr5:78301095chr1:183230438ENST0000028771371192_95217308.0RegionSubstrate binding
TgeneNMNAT2chr5:78301095chr1:183230438ENST0000029486871155_57212303.0RegionSubstrate binding
TgeneNMNAT2chr5:78301095chr1:183230438ENST0000029486871192_95212303.0RegionSubstrate binding
TgeneNMNAT2chr5:78301096chr1:183230438ENST00000287713711212_213217308.0RegionSubstrate binding
TgeneNMNAT2chr5:78301096chr1:183230438ENST0000028771371155_57217308.0RegionSubstrate binding
TgeneNMNAT2chr5:78301096chr1:183230438ENST0000028771371192_95217308.0RegionSubstrate binding
TgeneNMNAT2chr5:78301096chr1:183230438ENST0000029486871155_57212303.0RegionSubstrate binding
TgeneNMNAT2chr5:78301096chr1:183230438ENST0000029486871192_95212303.0RegionSubstrate binding


Top

Fusion Gene Sequence for DMGDH-NMNAT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>23250_23250_1_DMGDH-NMNAT2_DMGDH_chr5_78301095_ENST00000255189_NMNAT2_chr1_183230438_ENST00000287713_length(transcript)=7091nt_BP=2414nt
GCGCCTGCGCCCTCGGCCTCGGCCTAGTCATGCTCCGTCCCGGCGCGCAGCTGCTGCGGGGCCTCCTGCTGCGGAGCTGCCCGCTGCAGG
GCTCCCCCGGGCGCCCGCGCTCTGTCTGCGGCCGGGAAGGAGAGGAAAAACCACCCTTATCTGCAGAAACACAATGGAAAGACAGAGCAG
AAACAGTGATAATTGGAGGTGGCTGTGTTGGTGTGAGTCTGGCTTATCACCTGGCCAAAGCAGGGATGAAAGATGTGGTCCTGCTGGAGA
AATCAGAGCTCACGGCTGGATCTACCTGGCACGCAGCAGGTTTAACAACTTACTTTCATCCTGGAATAAACTTGAAGAAAATACATTATG
ATAGCATCAAACTTTATGAGAAACTGGAAGAAGAAACTGGTCAGGTGGTGGGATTCCATCAGCCAGGTAGTATCAGACTTGCTACCACCC
CTGTAAGGGTAGATGAATTTAAATATCAAATGACTCGGACTGGCTGGCATGCAACAGAACAGTATCTCATTGAACCTGAAAAAATTCAAG
AGATGTTCCCTTTACTCAACATGAATAAGGTTTTAGCTGGATTGTATAATCCTGGAGATGGTCACATTGATCCTTATTCTCTAACTATGG
CACTGGCTGCTGGGGCTAGGAAATGTGGTGCCCTTTTAAAATATCCTGCACCAGTAACTTCTCTGAAAGCCAGGTCAGATGGAACATGGG
ACGTTGAAACACCACAGGGGTCTATGAGAGCAAATAGAATTGTGAATGCTGCAGGATTTTGGGCTCGTGAAGTAGGTAAAATGATTGGAC
TAGAACATCCTCTCATTCCGGTTCAACATCAATATGTTGTTACATCGACTATATCTGAAGTGAAAGCTTTGAAACGAGAACTGCCTGTGC
TCCGTGACCTGGAAGGATCATATTATCTCCGACAGGAAAGGGATGGGCTTTTGTTTGGTCCATATGAAAGTCAAGAGAAAATGAAAGTTC
AGGACTCCTGGGTCACCAATGGAGTTCCTCCAGGTTTTGGAAAGGAACTCTTTGAGTCTGATCTAGATCGAATCATGGAACACATCAAAG
CTGCCATGGAAATGGTTCCTGTCTTGAAAAAGGCTGACATCATCAATGTTGTCAATGGTCCTATCACGTATTCTCCTGACATTCTGCCTA
TGGTGGGGCCCCATCAGGGGGTCAGAAACTACTGGGTGGCTATAGGCTTTGGATATGGCATAATCCACGCTGGTGGGGTAGGGAAATATC
TCAGTGACTGGATCCTGCATGGAGAACCTCCTTTTGATCTGATAGAATTGGATCCTAATCGCTATGGCAAATGGACAACAACCCAGTACA
CTGAGGCCAAAGCAAGAGAATCATATGGATTCAACAATATTGTTGGTTATCCTAAAGAAGAACGGTTTGCTGGGAGGCCGACTCAACGAG
TCAGTGGGCTCTATCAAAGGCTGGAGTCTAAGTGTTCCATGGGGTTCCATGCTGGCTGGGAGCAGCCGCACTGGTTCTACAAACCAGGCC
AGGACACTCAGTACAGGCCAAGTTTTCGCCGCACAAACTGGTTTGAGCCTGTGGGCTCGGAGTATAAACAGGTTATGCAAAGAGTAGCGG
TAACTGACCTATCACCATTTGGCAAGTTTAACATCAAAGGCCAAGATTCCATTAGACTACTGGACCATCTCTTTGCAAATGTCATTCCAA
AGGTGGGTTTTACAAATATAAGTCACATGTTAACACCCAAGGGTCGAGTGTATGCTGAGCTGACTGTTTCTCACCAATCTCCTGGGGAGT
TTCTTTTAATTACTGGCTCTGGATCAGAACTTCATGATCTTAGATGGATTGAAGAAGAAGCAGTCAAAGGTGGATATGATGTTGAAATTA
AAAACATAACTGATGAGCTTGGAGTTCTTGGAGTTGCTGGGCCACAGGCAAGAAAGGTCCTTCAGAAACTGACCTCTGAAGATCTTAGTG
ATGATGTTTTCAAGTTTCTTCAAACCAAGTCCTTAAAGGTTTCCAACATTCCTGTCACTGCTATTAGGATATCTTATACTGGTGAGCTGG
GTTGGGAGCTGTATCACAGAAGAGAAGATTCTGTGGCGCTGTATGACGCTATCATGAATGCAGGCCAGGAGGAGGGAATCGACAATTTTG
GAACCTATGCCATGAATGCCTTACGCCTGGAGAAAGCCTTCAGAGCCTGGGGGTTAGAGATGAACTGTGATACAAATCCTTTGGAAGCTG
GACTGGAATATTTTGTGAAGTTAAATAAGCCAGCAGACTTCATAGGAAAGCAAGCACTGAAACAGATTAAAGCCAAGGGGCTGAAACGAA
GACTGGTCTGCCTCACCTTGGCAACGGATGATGTTGATCCAGAGGGAAATGAAAGCATCTGGTACAATGGCAAGATGGAGGTGATTGTTG
GTGACTTTGGGATTGTGGTGGTGCCCCGGGATGCAGCCGACACAGACCGAATCATGAATCACTCCTCAATACTCCGCAAATACAAAAACA
ACATCATGGTGGTGAAGGATGACATCAACCATCCCATGTCTGTTGTCAGCTCAACCAAGAGCAGGCTGGCCCTGCAGCATGGGGACGGCC
ATGTTGTGGATTACCTGTCCCAGCCGGTCATCGACTACATCCTCAAAAGCCAGCTGTACATCAATGCCTCCGGCTAGCAGCCCCTCGTCC
TCCGGCAACACAATGGCCCCTCCATCTTTGTCAGCCCCCTGTTTCTCTCCTGCCTCTCTGTTTCTCCATCTCCTCGTCTTGACTGTTTTC
CCTACTTGCTGACTTAACCCCCCATAGTGTGGGGGACCTGCAGAGAACCATGGCATTCCCTATTCCACAGTCATCTTTGGACAGACTTTC
CTCTAGTCTCCGGGTTGGGGGTGGGTGAGGGAATGGGGTGGGAGTCGGGGGAAGTGCAGTCCTTGGAGATGTACTGGTGTCCGTCTCCCA
GCATGCTCTAGAGAGGCGGCTCTGGTGCCCATCCTCCCAGCACGCTCTGGGGAGGCGGCTCTGGTGCCCATCCTCCCAGCATGCTCTAGA
GAGGCGGCTCTGGTGCCCCTCCTCCCAGCATGCTCTGGGGAGGCGGCTCTGGCTCTTGCCTTCCCAGCATGCCCTTTACTACAAAGGGCT
ATTTTTCTTTTCTTTCTTTTGTTTATTTATTTTTCTTTGTTCACTCCCTGTAGAACTTGGATGAAATCAGTGTCCATGGTTCTTTATGTT
TGTAGTCTTGATGTGCTCCTGTGGTATTACTTCCCCTCTGATAGGACATTGTAGCCAGCCTCAGCACTCAGTGAGTTCATCAGGGCCACA
CCCAGTAGAGAAGGCCAAGCAACCTCCACTTCTTCAGCACCACACACACGCACACACACACACACGCACACATGCGTGTGCACCCGCGCA
CGCACATACACACACACATATAGCAGTAGCAGCAGCAGCAGCAGCAGCAGCAACCTTTGATCAGGAGTGAGATTTTCGGGTTCTGAAACC
TGGGACACGAGTCTGTGAATAGTCGGTTTTCTCAGAATAATTTGAATCTGTTTTCTTAGTTTCAAATGACCATTTCCCTGATGCTCTGAG
CTTATGATCACACAGAGCCAGTCCATCCTCATTTCCTGGTGGCATCTGTTCATTTACCTTTGTGGACTGTAGCTGATGGCACAGTGCGGG
TTCCCTACCAGCCAGGGGTTTCCAAGGGACCTTTGGAGGCCATGCTTAGACACATTCCTGTACCTGAGAACAACCACATAGGCAGGACCA
GATCCACATCGTGCAGTCGTGTCATAAAAAAACAAAACAAAACAAAAAAACACTAGGAGTCCACTCAACCCTGGAGGTCTTTGCTAATTG
GAATTATGTATTGTCTGTTGGGCTGGGAAATGTCTCTTTCATATTGTAAGTCCAGGATGAACTAGGAGAAAGCAATTTGTTGCCCTGATG
ATAACTGATGATTTTCACCCTCTCTAGCTGAGGTAACTCAGACAGTGCATGAGGTCAGTTTCTTCTTGAGAAGCAGTGCCTTGGTCTTGT
TTCTGTGGTTGGTTCTAGCCCCTGCAGAGCCTGGGAGCTGCAGGAACTGTCTGAGAAAATCTCCCTAATAGGGGAGTGGGTTCCCAGAAG
GGAGATCTGGGAGGGGTCAGGAGCCACTAAGTTGCTTCACTCCTTTTTTCTCTAATTTTCTACCTTCCTCTCTGTTCCTGCAGACAGTTT
TGCCAGCTTTGCTTCTGGTTACTAGGGTCTCATGCGTGTCCTGCTTGGAGAGCCATAAGGAAATTGCTGTCTTGTGCTTTGTGTCTCTCA
TCCAGTCTCTGGCTCTTGGGATTCTGGTCTTTGAGAAATAGTCCCTGAGTATTAGGATACTTTTATCAAAATCTAGTACCAGCTACGGCC
AGAAAGGGCCAGGTGGGACCTGAAAGCAAAGACAATGTTCTTTACCACACGTTTCACATCTGCAACATCCTTCAATTGCGGGAAAAGGAA
CTTGATTTAACAGAAGAACATGGTAGAGCAGCATCCAGAAAGTCTGTTATTCCTCTTGGATTTTTTGAAATAATCTTCAGAGGAAGGAAG
GAAAATCCTATTTTGGGGTATCAGTGTTTGACTAGGGATCATGAAATAATAAACTGAAAAAAACTTTAGAGTTCAGTTGATCCAACACTT
TCCTTTAAAAGTTGAGGGAGCAGAGGCCCATGGGATTAAATGGCTGGTCCAGGTCAGCCAGCAGGTGTAGGGCCTGACAAGAACATATTG
TTTCCCTGACCCCTAGGCCGTCACACCACACCCTCCATTTCCTCATGTTGCTGACCAGGTGCCCATATGATTTCTACACTTCCCAAGCCT
TACCCTGGCATCTTTCTTTTAAATTATATCTGTCCCAGGTGCTCTCCACACATAGGATGGTAATGCCAGTCCCAGGGGAGGGTGTGATAG
TAAGGAAGGCCACTGTTAGGTTTCCTTTAGAAATAAAGAGATCTCAGCAGCTTGGAAGAAATCCCAGAAGCGGACTCCATCAATCCAAGA
AAGAGTTGCTTTGTGGAAGGTGAAGGAAGACCCACAGAGTGCTCAGGATGATGCTATTGCTGGAGAGCGAAAGATGGAACAGCCTTGTCC
AGGCAGAACAGTCATAAGCCAGGAAATGAAACAAAGGAAAACAGGTGCCTGAATTTCCTGGGGAAACATGGCTTGTTTAAGGACTTGGAG
TTATGGATGGAATTTATGGGACCCACGTGAGCAGACCTGAGGAAGGCTCGATTTCTTTTGTTTCTTGGTCCACTCTGTCACTCTGCTCTG
GTCAAGCCCCATTTGGTCTACAGCCCATGAGAAGGAATGAGGCTGGTTCTGCACTCTCAGCATGCAGTCCGAAAGCATGTGGGAGTGGGG
AGGGAAAGTGAGATGAATTAAGACAAAGAACAGGTGCCATAGAAGTAGATTTCTAGGAATGAAGTGGGGCAGATCTTATCTTTGTGGATT
ACAGGCACTGTACTAAAAACAGGTTTCCTATTTAATATAAAAAGAAAGTGAATCTTCTTTTGGATAGAATCATCCATTCCCATCGCCGCA
CCCCCTACCCCCCAAACACACACACACACACACACACACACACACACACACACACACACACACACGCCCTACTCTTCATTTGCTAGGGGA
AGGTCACAGCACAACTAAATCCAGGACAGGACATTGTGACCATGACCCAGCCACAGTCAATACCAGAAAGATGATTCAGAGTCTGAAGTG
GTGCCCCAGGTGCCAACAGGATAACCTCTACCCCCCGACTTTGTCTCTGGGGTCCTGTTCCTTCCTGCAAAGCCCAATCCAAGACTGGCA
TGGCTCAGAGGTTGTGAGAAAGGCATGGACTGGAACAATCATGTCCAGAGGGGTCTGGAGCTTTGTTTCCTGTTCACCAGCAAAAAATGT
CTCTCCCATTTTTCTGAAAGTGGCTGATGTAAGAACAGGCAGAAGGAAAACCCTTTTTGTCAATAACTCTGTCCTTAAGGAATGGTCCTC
TGGGAGGGCTGTGCTGCTAGTGGGTACCTCAGTCACACACCCCCAACCCCAGGCAGCCTCTAGAGCCTTCTTGCTTTCATTTTCCTTGAA
TGTACATAGGAACAAGGGGGAAAGTCTCTTACTGAAGTGCCTGAAACCCAAAGCTAGAGCTTCTAGAGACGCCGTTCTTCCTGTCTCAGC
TTGGCCAGCCTTTCAACAATGTTCTCTAGTTTCAAGCTCCAGCTTCTCAGAAAGAATTAAAGAACTTGCTGTTCAAATTAAGTAGAAAGT
GAGACTCAATAATAACTGAACTACAGCAAAAGGCAGAGAATTACAGGGAGAAAAAACTTGTACTTACCAGCCCAATTCTACTCTCCTCAA
ACTGACACACACACACACACACACACACACACACACACACACACACTCTTTTAGGGGACTAAGAGAGAGAAGCATGTTATTACATTTTAC
TCATCCAAACAGTAATGCAAAAATAAAACGGTAGAATATGAAAAGCTCAGGATCTCTCCCAAGGCTACCTACTGCAGGAGGGCCAACAGG
TGAGATGGGAAGAATGGAAACAGGGACCGATTTTGTAGCTCATACAATTAGGACACCTTAGGAATAGCATTGTAGTAATGGTGATGAATA
TGCTCTGCCAAATTCATCCAGTCTGCACCATCTTATAGCTGCCCAGCACACTCGACTGTTCATGTGGTCTCTTTGTAGTGTGAGTTTGGA
GTGTCCTATTAGCCTGTTCTGGTTAGGAATGAGTTAACGGCTCTTTCCCTCAACCTTAGTCTAGTCCCAGGGCTGAGGATTCAGCTGGAT
CCACATGGTCTTGAGGGTTGGCATGAGGAGGGGGAAGCTTTTTTGAATCGCTTTTTGATCACATAATCTGCCATTTTAAGAGTAAGATTT
GCTTTATGGAAATCAATTCATTAATAAAAAATGATATTCAAGTTGCAATACCATTTCACAGTGAAATATTTTGAGTACAATTTTGTTGCT

>23250_23250_1_DMGDH-NMNAT2_DMGDH_chr5_78301095_ENST00000255189_NMNAT2_chr1_183230438_ENST00000287713_length(amino acids)=885AA_BP=795
MLRPGAQLLRGLLLRSCPLQGSPGRPRSVCGREGEEKPPLSAETQWKDRAETVIIGGGCVGVSLAYHLAKAGMKDVVLLEKSELTAGSTW
HAAGLTTYFHPGINLKKIHYDSIKLYEKLEEETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMNK
VLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMRANRIVNAAGFWAREVGKMIGLEHPLIPVQH
QYVVTSTISEVKALKRELPVLRDLEGSYYLRQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLK
KADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIGFGYGIIHAGGVGKYLSDWILHGEPPFDLIELDPNRYGKWTTTQYTEAKARESYG
FNNIVGYPKEERFAGRPTQRVSGLYQRLESKCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKF
NIKGQDSIRLLDHLFANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSELHDLRWIEEEAVKGGYDVEIKNITDELGVL
GVAGPQARKVLQKLTSEDLSDDVFKFLQTKSLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRL
EKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVCLTLATDDVDPEGNESIWYNGKMEVIVGDFGIVVVPR

--------------------------------------------------------------
>23250_23250_2_DMGDH-NMNAT2_DMGDH_chr5_78301095_ENST00000255189_NMNAT2_chr1_183230438_ENST00000294868_length(transcript)=7091nt_BP=2414nt
GCGCCTGCGCCCTCGGCCTCGGCCTAGTCATGCTCCGTCCCGGCGCGCAGCTGCTGCGGGGCCTCCTGCTGCGGAGCTGCCCGCTGCAGG
GCTCCCCCGGGCGCCCGCGCTCTGTCTGCGGCCGGGAAGGAGAGGAAAAACCACCCTTATCTGCAGAAACACAATGGAAAGACAGAGCAG
AAACAGTGATAATTGGAGGTGGCTGTGTTGGTGTGAGTCTGGCTTATCACCTGGCCAAAGCAGGGATGAAAGATGTGGTCCTGCTGGAGA
AATCAGAGCTCACGGCTGGATCTACCTGGCACGCAGCAGGTTTAACAACTTACTTTCATCCTGGAATAAACTTGAAGAAAATACATTATG
ATAGCATCAAACTTTATGAGAAACTGGAAGAAGAAACTGGTCAGGTGGTGGGATTCCATCAGCCAGGTAGTATCAGACTTGCTACCACCC
CTGTAAGGGTAGATGAATTTAAATATCAAATGACTCGGACTGGCTGGCATGCAACAGAACAGTATCTCATTGAACCTGAAAAAATTCAAG
AGATGTTCCCTTTACTCAACATGAATAAGGTTTTAGCTGGATTGTATAATCCTGGAGATGGTCACATTGATCCTTATTCTCTAACTATGG
CACTGGCTGCTGGGGCTAGGAAATGTGGTGCCCTTTTAAAATATCCTGCACCAGTAACTTCTCTGAAAGCCAGGTCAGATGGAACATGGG
ACGTTGAAACACCACAGGGGTCTATGAGAGCAAATAGAATTGTGAATGCTGCAGGATTTTGGGCTCGTGAAGTAGGTAAAATGATTGGAC
TAGAACATCCTCTCATTCCGGTTCAACATCAATATGTTGTTACATCGACTATATCTGAAGTGAAAGCTTTGAAACGAGAACTGCCTGTGC
TCCGTGACCTGGAAGGATCATATTATCTCCGACAGGAAAGGGATGGGCTTTTGTTTGGTCCATATGAAAGTCAAGAGAAAATGAAAGTTC
AGGACTCCTGGGTCACCAATGGAGTTCCTCCAGGTTTTGGAAAGGAACTCTTTGAGTCTGATCTAGATCGAATCATGGAACACATCAAAG
CTGCCATGGAAATGGTTCCTGTCTTGAAAAAGGCTGACATCATCAATGTTGTCAATGGTCCTATCACGTATTCTCCTGACATTCTGCCTA
TGGTGGGGCCCCATCAGGGGGTCAGAAACTACTGGGTGGCTATAGGCTTTGGATATGGCATAATCCACGCTGGTGGGGTAGGGAAATATC
TCAGTGACTGGATCCTGCATGGAGAACCTCCTTTTGATCTGATAGAATTGGATCCTAATCGCTATGGCAAATGGACAACAACCCAGTACA
CTGAGGCCAAAGCAAGAGAATCATATGGATTCAACAATATTGTTGGTTATCCTAAAGAAGAACGGTTTGCTGGGAGGCCGACTCAACGAG
TCAGTGGGCTCTATCAAAGGCTGGAGTCTAAGTGTTCCATGGGGTTCCATGCTGGCTGGGAGCAGCCGCACTGGTTCTACAAACCAGGCC
AGGACACTCAGTACAGGCCAAGTTTTCGCCGCACAAACTGGTTTGAGCCTGTGGGCTCGGAGTATAAACAGGTTATGCAAAGAGTAGCGG
TAACTGACCTATCACCATTTGGCAAGTTTAACATCAAAGGCCAAGATTCCATTAGACTACTGGACCATCTCTTTGCAAATGTCATTCCAA
AGGTGGGTTTTACAAATATAAGTCACATGTTAACACCCAAGGGTCGAGTGTATGCTGAGCTGACTGTTTCTCACCAATCTCCTGGGGAGT
TTCTTTTAATTACTGGCTCTGGATCAGAACTTCATGATCTTAGATGGATTGAAGAAGAAGCAGTCAAAGGTGGATATGATGTTGAAATTA
AAAACATAACTGATGAGCTTGGAGTTCTTGGAGTTGCTGGGCCACAGGCAAGAAAGGTCCTTCAGAAACTGACCTCTGAAGATCTTAGTG
ATGATGTTTTCAAGTTTCTTCAAACCAAGTCCTTAAAGGTTTCCAACATTCCTGTCACTGCTATTAGGATATCTTATACTGGTGAGCTGG
GTTGGGAGCTGTATCACAGAAGAGAAGATTCTGTGGCGCTGTATGACGCTATCATGAATGCAGGCCAGGAGGAGGGAATCGACAATTTTG
GAACCTATGCCATGAATGCCTTACGCCTGGAGAAAGCCTTCAGAGCCTGGGGGTTAGAGATGAACTGTGATACAAATCCTTTGGAAGCTG
GACTGGAATATTTTGTGAAGTTAAATAAGCCAGCAGACTTCATAGGAAAGCAAGCACTGAAACAGATTAAAGCCAAGGGGCTGAAACGAA
GACTGGTCTGCCTCACCTTGGCAACGGATGATGTTGATCCAGAGGGAAATGAAAGCATCTGGTACAATGGCAAGATGGAGGTGATTGTTG
GTGACTTTGGGATTGTGGTGGTGCCCCGGGATGCAGCCGACACAGACCGAATCATGAATCACTCCTCAATACTCCGCAAATACAAAAACA
ACATCATGGTGGTGAAGGATGACATCAACCATCCCATGTCTGTTGTCAGCTCAACCAAGAGCAGGCTGGCCCTGCAGCATGGGGACGGCC
ATGTTGTGGATTACCTGTCCCAGCCGGTCATCGACTACATCCTCAAAAGCCAGCTGTACATCAATGCCTCCGGCTAGCAGCCCCTCGTCC
TCCGGCAACACAATGGCCCCTCCATCTTTGTCAGCCCCCTGTTTCTCTCCTGCCTCTCTGTTTCTCCATCTCCTCGTCTTGACTGTTTTC
CCTACTTGCTGACTTAACCCCCCATAGTGTGGGGGACCTGCAGAGAACCATGGCATTCCCTATTCCACAGTCATCTTTGGACAGACTTTC
CTCTAGTCTCCGGGTTGGGGGTGGGTGAGGGAATGGGGTGGGAGTCGGGGGAAGTGCAGTCCTTGGAGATGTACTGGTGTCCGTCTCCCA
GCATGCTCTAGAGAGGCGGCTCTGGTGCCCATCCTCCCAGCACGCTCTGGGGAGGCGGCTCTGGTGCCCATCCTCCCAGCATGCTCTAGA
GAGGCGGCTCTGGTGCCCCTCCTCCCAGCATGCTCTGGGGAGGCGGCTCTGGCTCTTGCCTTCCCAGCATGCCCTTTACTACAAAGGGCT
ATTTTTCTTTTCTTTCTTTTGTTTATTTATTTTTCTTTGTTCACTCCCTGTAGAACTTGGATGAAATCAGTGTCCATGGTTCTTTATGTT
TGTAGTCTTGATGTGCTCCTGTGGTATTACTTCCCCTCTGATAGGACATTGTAGCCAGCCTCAGCACTCAGTGAGTTCATCAGGGCCACA
CCCAGTAGAGAAGGCCAAGCAACCTCCACTTCTTCAGCACCACACACACGCACACACACACACACGCACACATGCGTGTGCACCCGCGCA
CGCACATACACACACACATATAGCAGTAGCAGCAGCAGCAGCAGCAGCAGCAACCTTTGATCAGGAGTGAGATTTTCGGGTTCTGAAACC
TGGGACACGAGTCTGTGAATAGTCGGTTTTCTCAGAATAATTTGAATCTGTTTTCTTAGTTTCAAATGACCATTTCCCTGATGCTCTGAG
CTTATGATCACACAGAGCCAGTCCATCCTCATTTCCTGGTGGCATCTGTTCATTTACCTTTGTGGACTGTAGCTGATGGCACAGTGCGGG
TTCCCTACCAGCCAGGGGTTTCCAAGGGACCTTTGGAGGCCATGCTTAGACACATTCCTGTACCTGAGAACAACCACATAGGCAGGACCA
GATCCACATCGTGCAGTCGTGTCATAAAAAAACAAAACAAAACAAAAAAACACTAGGAGTCCACTCAACCCTGGAGGTCTTTGCTAATTG
GAATTATGTATTGTCTGTTGGGCTGGGAAATGTCTCTTTCATATTGTAAGTCCAGGATGAACTAGGAGAAAGCAATTTGTTGCCCTGATG
ATAACTGATGATTTTCACCCTCTCTAGCTGAGGTAACTCAGACAGTGCATGAGGTCAGTTTCTTCTTGAGAAGCAGTGCCTTGGTCTTGT
TTCTGTGGTTGGTTCTAGCCCCTGCAGAGCCTGGGAGCTGCAGGAACTGTCTGAGAAAATCTCCCTAATAGGGGAGTGGGTTCCCAGAAG
GGAGATCTGGGAGGGGTCAGGAGCCACTAAGTTGCTTCACTCCTTTTTTCTCTAATTTTCTACCTTCCTCTCTGTTCCTGCAGACAGTTT
TGCCAGCTTTGCTTCTGGTTACTAGGGTCTCATGCGTGTCCTGCTTGGAGAGCCATAAGGAAATTGCTGTCTTGTGCTTTGTGTCTCTCA
TCCAGTCTCTGGCTCTTGGGATTCTGGTCTTTGAGAAATAGTCCCTGAGTATTAGGATACTTTTATCAAAATCTAGTACCAGCTACGGCC
AGAAAGGGCCAGGTGGGACCTGAAAGCAAAGACAATGTTCTTTACCACACGTTTCACATCTGCAACATCCTTCAATTGCGGGAAAAGGAA
CTTGATTTAACAGAAGAACATGGTAGAGCAGCATCCAGAAAGTCTGTTATTCCTCTTGGATTTTTTGAAATAATCTTCAGAGGAAGGAAG
GAAAATCCTATTTTGGGGTATCAGTGTTTGACTAGGGATCATGAAATAATAAACTGAAAAAAACTTTAGAGTTCAGTTGATCCAACACTT
TCCTTTAAAAGTTGAGGGAGCAGAGGCCCATGGGATTAAATGGCTGGTCCAGGTCAGCCAGCAGGTGTAGGGCCTGACAAGAACATATTG
TTTCCCTGACCCCTAGGCCGTCACACCACACCCTCCATTTCCTCATGTTGCTGACCAGGTGCCCATATGATTTCTACACTTCCCAAGCCT
TACCCTGGCATCTTTCTTTTAAATTATATCTGTCCCAGGTGCTCTCCACACATAGGATGGTAATGCCAGTCCCAGGGGAGGGTGTGATAG
TAAGGAAGGCCACTGTTAGGTTTCCTTTAGAAATAAAGAGATCTCAGCAGCTTGGAAGAAATCCCAGAAGCGGACTCCATCAATCCAAGA
AAGAGTTGCTTTGTGGAAGGTGAAGGAAGACCCACAGAGTGCTCAGGATGATGCTATTGCTGGAGAGCGAAAGATGGAACAGCCTTGTCC
AGGCAGAACAGTCATAAGCCAGGAAATGAAACAAAGGAAAACAGGTGCCTGAATTTCCTGGGGAAACATGGCTTGTTTAAGGACTTGGAG
TTATGGATGGAATTTATGGGACCCACGTGAGCAGACCTGAGGAAGGCTCGATTTCTTTTGTTTCTTGGTCCACTCTGTCACTCTGCTCTG
GTCAAGCCCCATTTGGTCTACAGCCCATGAGAAGGAATGAGGCTGGTTCTGCACTCTCAGCATGCAGTCCGAAAGCATGTGGGAGTGGGG
AGGGAAAGTGAGATGAATTAAGACAAAGAACAGGTGCCATAGAAGTAGATTTCTAGGAATGAAGTGGGGCAGATCTTATCTTTGTGGATT
ACAGGCACTGTACTAAAAACAGGTTTCCTATTTAATATAAAAAGAAAGTGAATCTTCTTTTGGATAGAATCATCCATTCCCATCGCCGCA
CCCCCTACCCCCCAAACACACACACACACACACACACACACACACACACACACACACACACACACGCCCTACTCTTCATTTGCTAGGGGA
AGGTCACAGCACAACTAAATCCAGGACAGGACATTGTGACCATGACCCAGCCACAGTCAATACCAGAAAGATGATTCAGAGTCTGAAGTG
GTGCCCCAGGTGCCAACAGGATAACCTCTACCCCCCGACTTTGTCTCTGGGGTCCTGTTCCTTCCTGCAAAGCCCAATCCAAGACTGGCA
TGGCTCAGAGGTTGTGAGAAAGGCATGGACTGGAACAATCATGTCCAGAGGGGTCTGGAGCTTTGTTTCCTGTTCACCAGCAAAAAATGT
CTCTCCCATTTTTCTGAAAGTGGCTGATGTAAGAACAGGCAGAAGGAAAACCCTTTTTGTCAATAACTCTGTCCTTAAGGAATGGTCCTC
TGGGAGGGCTGTGCTGCTAGTGGGTACCTCAGTCACACACCCCCAACCCCAGGCAGCCTCTAGAGCCTTCTTGCTTTCATTTTCCTTGAA
TGTACATAGGAACAAGGGGGAAAGTCTCTTACTGAAGTGCCTGAAACCCAAAGCTAGAGCTTCTAGAGACGCCGTTCTTCCTGTCTCAGC
TTGGCCAGCCTTTCAACAATGTTCTCTAGTTTCAAGCTCCAGCTTCTCAGAAAGAATTAAAGAACTTGCTGTTCAAATTAAGTAGAAAGT
GAGACTCAATAATAACTGAACTACAGCAAAAGGCAGAGAATTACAGGGAGAAAAAACTTGTACTTACCAGCCCAATTCTACTCTCCTCAA
ACTGACACACACACACACACACACACACACACACACACACACACACTCTTTTAGGGGACTAAGAGAGAGAAGCATGTTATTACATTTTAC
TCATCCAAACAGTAATGCAAAAATAAAACGGTAGAATATGAAAAGCTCAGGATCTCTCCCAAGGCTACCTACTGCAGGAGGGCCAACAGG
TGAGATGGGAAGAATGGAAACAGGGACCGATTTTGTAGCTCATACAATTAGGACACCTTAGGAATAGCATTGTAGTAATGGTGATGAATA
TGCTCTGCCAAATTCATCCAGTCTGCACCATCTTATAGCTGCCCAGCACACTCGACTGTTCATGTGGTCTCTTTGTAGTGTGAGTTTGGA
GTGTCCTATTAGCCTGTTCTGGTTAGGAATGAGTTAACGGCTCTTTCCCTCAACCTTAGTCTAGTCCCAGGGCTGAGGATTCAGCTGGAT
CCACATGGTCTTGAGGGTTGGCATGAGGAGGGGGAAGCTTTTTTGAATCGCTTTTTGATCACATAATCTGCCATTTTAAGAGTAAGATTT
GCTTTATGGAAATCAATTCATTAATAAAAAATGATATTCAAGTTGCAATACCATTTCACAGTGAAATATTTTGAGTACAATTTTGTTGCT

>23250_23250_2_DMGDH-NMNAT2_DMGDH_chr5_78301095_ENST00000255189_NMNAT2_chr1_183230438_ENST00000294868_length(amino acids)=885AA_BP=795
MLRPGAQLLRGLLLRSCPLQGSPGRPRSVCGREGEEKPPLSAETQWKDRAETVIIGGGCVGVSLAYHLAKAGMKDVVLLEKSELTAGSTW
HAAGLTTYFHPGINLKKIHYDSIKLYEKLEEETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMNK
VLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMRANRIVNAAGFWAREVGKMIGLEHPLIPVQH
QYVVTSTISEVKALKRELPVLRDLEGSYYLRQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLK
KADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIGFGYGIIHAGGVGKYLSDWILHGEPPFDLIELDPNRYGKWTTTQYTEAKARESYG
FNNIVGYPKEERFAGRPTQRVSGLYQRLESKCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKF
NIKGQDSIRLLDHLFANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSELHDLRWIEEEAVKGGYDVEIKNITDELGVL
GVAGPQARKVLQKLTSEDLSDDVFKFLQTKSLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRL
EKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVCLTLATDDVDPEGNESIWYNGKMEVIVGDFGIVVVPR

--------------------------------------------------------------
>23250_23250_3_DMGDH-NMNAT2_DMGDH_chr5_78301096_ENST00000255189_NMNAT2_chr1_183230438_ENST00000287713_length(transcript)=7091nt_BP=2414nt
GCGCCTGCGCCCTCGGCCTCGGCCTAGTCATGCTCCGTCCCGGCGCGCAGCTGCTGCGGGGCCTCCTGCTGCGGAGCTGCCCGCTGCAGG
GCTCCCCCGGGCGCCCGCGCTCTGTCTGCGGCCGGGAAGGAGAGGAAAAACCACCCTTATCTGCAGAAACACAATGGAAAGACAGAGCAG
AAACAGTGATAATTGGAGGTGGCTGTGTTGGTGTGAGTCTGGCTTATCACCTGGCCAAAGCAGGGATGAAAGATGTGGTCCTGCTGGAGA
AATCAGAGCTCACGGCTGGATCTACCTGGCACGCAGCAGGTTTAACAACTTACTTTCATCCTGGAATAAACTTGAAGAAAATACATTATG
ATAGCATCAAACTTTATGAGAAACTGGAAGAAGAAACTGGTCAGGTGGTGGGATTCCATCAGCCAGGTAGTATCAGACTTGCTACCACCC
CTGTAAGGGTAGATGAATTTAAATATCAAATGACTCGGACTGGCTGGCATGCAACAGAACAGTATCTCATTGAACCTGAAAAAATTCAAG
AGATGTTCCCTTTACTCAACATGAATAAGGTTTTAGCTGGATTGTATAATCCTGGAGATGGTCACATTGATCCTTATTCTCTAACTATGG
CACTGGCTGCTGGGGCTAGGAAATGTGGTGCCCTTTTAAAATATCCTGCACCAGTAACTTCTCTGAAAGCCAGGTCAGATGGAACATGGG
ACGTTGAAACACCACAGGGGTCTATGAGAGCAAATAGAATTGTGAATGCTGCAGGATTTTGGGCTCGTGAAGTAGGTAAAATGATTGGAC
TAGAACATCCTCTCATTCCGGTTCAACATCAATATGTTGTTACATCGACTATATCTGAAGTGAAAGCTTTGAAACGAGAACTGCCTGTGC
TCCGTGACCTGGAAGGATCATATTATCTCCGACAGGAAAGGGATGGGCTTTTGTTTGGTCCATATGAAAGTCAAGAGAAAATGAAAGTTC
AGGACTCCTGGGTCACCAATGGAGTTCCTCCAGGTTTTGGAAAGGAACTCTTTGAGTCTGATCTAGATCGAATCATGGAACACATCAAAG
CTGCCATGGAAATGGTTCCTGTCTTGAAAAAGGCTGACATCATCAATGTTGTCAATGGTCCTATCACGTATTCTCCTGACATTCTGCCTA
TGGTGGGGCCCCATCAGGGGGTCAGAAACTACTGGGTGGCTATAGGCTTTGGATATGGCATAATCCACGCTGGTGGGGTAGGGAAATATC
TCAGTGACTGGATCCTGCATGGAGAACCTCCTTTTGATCTGATAGAATTGGATCCTAATCGCTATGGCAAATGGACAACAACCCAGTACA
CTGAGGCCAAAGCAAGAGAATCATATGGATTCAACAATATTGTTGGTTATCCTAAAGAAGAACGGTTTGCTGGGAGGCCGACTCAACGAG
TCAGTGGGCTCTATCAAAGGCTGGAGTCTAAGTGTTCCATGGGGTTCCATGCTGGCTGGGAGCAGCCGCACTGGTTCTACAAACCAGGCC
AGGACACTCAGTACAGGCCAAGTTTTCGCCGCACAAACTGGTTTGAGCCTGTGGGCTCGGAGTATAAACAGGTTATGCAAAGAGTAGCGG
TAACTGACCTATCACCATTTGGCAAGTTTAACATCAAAGGCCAAGATTCCATTAGACTACTGGACCATCTCTTTGCAAATGTCATTCCAA
AGGTGGGTTTTACAAATATAAGTCACATGTTAACACCCAAGGGTCGAGTGTATGCTGAGCTGACTGTTTCTCACCAATCTCCTGGGGAGT
TTCTTTTAATTACTGGCTCTGGATCAGAACTTCATGATCTTAGATGGATTGAAGAAGAAGCAGTCAAAGGTGGATATGATGTTGAAATTA
AAAACATAACTGATGAGCTTGGAGTTCTTGGAGTTGCTGGGCCACAGGCAAGAAAGGTCCTTCAGAAACTGACCTCTGAAGATCTTAGTG
ATGATGTTTTCAAGTTTCTTCAAACCAAGTCCTTAAAGGTTTCCAACATTCCTGTCACTGCTATTAGGATATCTTATACTGGTGAGCTGG
GTTGGGAGCTGTATCACAGAAGAGAAGATTCTGTGGCGCTGTATGACGCTATCATGAATGCAGGCCAGGAGGAGGGAATCGACAATTTTG
GAACCTATGCCATGAATGCCTTACGCCTGGAGAAAGCCTTCAGAGCCTGGGGGTTAGAGATGAACTGTGATACAAATCCTTTGGAAGCTG
GACTGGAATATTTTGTGAAGTTAAATAAGCCAGCAGACTTCATAGGAAAGCAAGCACTGAAACAGATTAAAGCCAAGGGGCTGAAACGAA
GACTGGTCTGCCTCACCTTGGCAACGGATGATGTTGATCCAGAGGGAAATGAAAGCATCTGGTACAATGGCAAGATGGAGGTGATTGTTG
GTGACTTTGGGATTGTGGTGGTGCCCCGGGATGCAGCCGACACAGACCGAATCATGAATCACTCCTCAATACTCCGCAAATACAAAAACA
ACATCATGGTGGTGAAGGATGACATCAACCATCCCATGTCTGTTGTCAGCTCAACCAAGAGCAGGCTGGCCCTGCAGCATGGGGACGGCC
ATGTTGTGGATTACCTGTCCCAGCCGGTCATCGACTACATCCTCAAAAGCCAGCTGTACATCAATGCCTCCGGCTAGCAGCCCCTCGTCC
TCCGGCAACACAATGGCCCCTCCATCTTTGTCAGCCCCCTGTTTCTCTCCTGCCTCTCTGTTTCTCCATCTCCTCGTCTTGACTGTTTTC
CCTACTTGCTGACTTAACCCCCCATAGTGTGGGGGACCTGCAGAGAACCATGGCATTCCCTATTCCACAGTCATCTTTGGACAGACTTTC
CTCTAGTCTCCGGGTTGGGGGTGGGTGAGGGAATGGGGTGGGAGTCGGGGGAAGTGCAGTCCTTGGAGATGTACTGGTGTCCGTCTCCCA
GCATGCTCTAGAGAGGCGGCTCTGGTGCCCATCCTCCCAGCACGCTCTGGGGAGGCGGCTCTGGTGCCCATCCTCCCAGCATGCTCTAGA
GAGGCGGCTCTGGTGCCCCTCCTCCCAGCATGCTCTGGGGAGGCGGCTCTGGCTCTTGCCTTCCCAGCATGCCCTTTACTACAAAGGGCT
ATTTTTCTTTTCTTTCTTTTGTTTATTTATTTTTCTTTGTTCACTCCCTGTAGAACTTGGATGAAATCAGTGTCCATGGTTCTTTATGTT
TGTAGTCTTGATGTGCTCCTGTGGTATTACTTCCCCTCTGATAGGACATTGTAGCCAGCCTCAGCACTCAGTGAGTTCATCAGGGCCACA
CCCAGTAGAGAAGGCCAAGCAACCTCCACTTCTTCAGCACCACACACACGCACACACACACACACGCACACATGCGTGTGCACCCGCGCA
CGCACATACACACACACATATAGCAGTAGCAGCAGCAGCAGCAGCAGCAGCAACCTTTGATCAGGAGTGAGATTTTCGGGTTCTGAAACC
TGGGACACGAGTCTGTGAATAGTCGGTTTTCTCAGAATAATTTGAATCTGTTTTCTTAGTTTCAAATGACCATTTCCCTGATGCTCTGAG
CTTATGATCACACAGAGCCAGTCCATCCTCATTTCCTGGTGGCATCTGTTCATTTACCTTTGTGGACTGTAGCTGATGGCACAGTGCGGG
TTCCCTACCAGCCAGGGGTTTCCAAGGGACCTTTGGAGGCCATGCTTAGACACATTCCTGTACCTGAGAACAACCACATAGGCAGGACCA
GATCCACATCGTGCAGTCGTGTCATAAAAAAACAAAACAAAACAAAAAAACACTAGGAGTCCACTCAACCCTGGAGGTCTTTGCTAATTG
GAATTATGTATTGTCTGTTGGGCTGGGAAATGTCTCTTTCATATTGTAAGTCCAGGATGAACTAGGAGAAAGCAATTTGTTGCCCTGATG
ATAACTGATGATTTTCACCCTCTCTAGCTGAGGTAACTCAGACAGTGCATGAGGTCAGTTTCTTCTTGAGAAGCAGTGCCTTGGTCTTGT
TTCTGTGGTTGGTTCTAGCCCCTGCAGAGCCTGGGAGCTGCAGGAACTGTCTGAGAAAATCTCCCTAATAGGGGAGTGGGTTCCCAGAAG
GGAGATCTGGGAGGGGTCAGGAGCCACTAAGTTGCTTCACTCCTTTTTTCTCTAATTTTCTACCTTCCTCTCTGTTCCTGCAGACAGTTT
TGCCAGCTTTGCTTCTGGTTACTAGGGTCTCATGCGTGTCCTGCTTGGAGAGCCATAAGGAAATTGCTGTCTTGTGCTTTGTGTCTCTCA
TCCAGTCTCTGGCTCTTGGGATTCTGGTCTTTGAGAAATAGTCCCTGAGTATTAGGATACTTTTATCAAAATCTAGTACCAGCTACGGCC
AGAAAGGGCCAGGTGGGACCTGAAAGCAAAGACAATGTTCTTTACCACACGTTTCACATCTGCAACATCCTTCAATTGCGGGAAAAGGAA
CTTGATTTAACAGAAGAACATGGTAGAGCAGCATCCAGAAAGTCTGTTATTCCTCTTGGATTTTTTGAAATAATCTTCAGAGGAAGGAAG
GAAAATCCTATTTTGGGGTATCAGTGTTTGACTAGGGATCATGAAATAATAAACTGAAAAAAACTTTAGAGTTCAGTTGATCCAACACTT
TCCTTTAAAAGTTGAGGGAGCAGAGGCCCATGGGATTAAATGGCTGGTCCAGGTCAGCCAGCAGGTGTAGGGCCTGACAAGAACATATTG
TTTCCCTGACCCCTAGGCCGTCACACCACACCCTCCATTTCCTCATGTTGCTGACCAGGTGCCCATATGATTTCTACACTTCCCAAGCCT
TACCCTGGCATCTTTCTTTTAAATTATATCTGTCCCAGGTGCTCTCCACACATAGGATGGTAATGCCAGTCCCAGGGGAGGGTGTGATAG
TAAGGAAGGCCACTGTTAGGTTTCCTTTAGAAATAAAGAGATCTCAGCAGCTTGGAAGAAATCCCAGAAGCGGACTCCATCAATCCAAGA
AAGAGTTGCTTTGTGGAAGGTGAAGGAAGACCCACAGAGTGCTCAGGATGATGCTATTGCTGGAGAGCGAAAGATGGAACAGCCTTGTCC
AGGCAGAACAGTCATAAGCCAGGAAATGAAACAAAGGAAAACAGGTGCCTGAATTTCCTGGGGAAACATGGCTTGTTTAAGGACTTGGAG
TTATGGATGGAATTTATGGGACCCACGTGAGCAGACCTGAGGAAGGCTCGATTTCTTTTGTTTCTTGGTCCACTCTGTCACTCTGCTCTG
GTCAAGCCCCATTTGGTCTACAGCCCATGAGAAGGAATGAGGCTGGTTCTGCACTCTCAGCATGCAGTCCGAAAGCATGTGGGAGTGGGG
AGGGAAAGTGAGATGAATTAAGACAAAGAACAGGTGCCATAGAAGTAGATTTCTAGGAATGAAGTGGGGCAGATCTTATCTTTGTGGATT
ACAGGCACTGTACTAAAAACAGGTTTCCTATTTAATATAAAAAGAAAGTGAATCTTCTTTTGGATAGAATCATCCATTCCCATCGCCGCA
CCCCCTACCCCCCAAACACACACACACACACACACACACACACACACACACACACACACACACACGCCCTACTCTTCATTTGCTAGGGGA
AGGTCACAGCACAACTAAATCCAGGACAGGACATTGTGACCATGACCCAGCCACAGTCAATACCAGAAAGATGATTCAGAGTCTGAAGTG
GTGCCCCAGGTGCCAACAGGATAACCTCTACCCCCCGACTTTGTCTCTGGGGTCCTGTTCCTTCCTGCAAAGCCCAATCCAAGACTGGCA
TGGCTCAGAGGTTGTGAGAAAGGCATGGACTGGAACAATCATGTCCAGAGGGGTCTGGAGCTTTGTTTCCTGTTCACCAGCAAAAAATGT
CTCTCCCATTTTTCTGAAAGTGGCTGATGTAAGAACAGGCAGAAGGAAAACCCTTTTTGTCAATAACTCTGTCCTTAAGGAATGGTCCTC
TGGGAGGGCTGTGCTGCTAGTGGGTACCTCAGTCACACACCCCCAACCCCAGGCAGCCTCTAGAGCCTTCTTGCTTTCATTTTCCTTGAA
TGTACATAGGAACAAGGGGGAAAGTCTCTTACTGAAGTGCCTGAAACCCAAAGCTAGAGCTTCTAGAGACGCCGTTCTTCCTGTCTCAGC
TTGGCCAGCCTTTCAACAATGTTCTCTAGTTTCAAGCTCCAGCTTCTCAGAAAGAATTAAAGAACTTGCTGTTCAAATTAAGTAGAAAGT
GAGACTCAATAATAACTGAACTACAGCAAAAGGCAGAGAATTACAGGGAGAAAAAACTTGTACTTACCAGCCCAATTCTACTCTCCTCAA
ACTGACACACACACACACACACACACACACACACACACACACACACTCTTTTAGGGGACTAAGAGAGAGAAGCATGTTATTACATTTTAC
TCATCCAAACAGTAATGCAAAAATAAAACGGTAGAATATGAAAAGCTCAGGATCTCTCCCAAGGCTACCTACTGCAGGAGGGCCAACAGG
TGAGATGGGAAGAATGGAAACAGGGACCGATTTTGTAGCTCATACAATTAGGACACCTTAGGAATAGCATTGTAGTAATGGTGATGAATA
TGCTCTGCCAAATTCATCCAGTCTGCACCATCTTATAGCTGCCCAGCACACTCGACTGTTCATGTGGTCTCTTTGTAGTGTGAGTTTGGA
GTGTCCTATTAGCCTGTTCTGGTTAGGAATGAGTTAACGGCTCTTTCCCTCAACCTTAGTCTAGTCCCAGGGCTGAGGATTCAGCTGGAT
CCACATGGTCTTGAGGGTTGGCATGAGGAGGGGGAAGCTTTTTTGAATCGCTTTTTGATCACATAATCTGCCATTTTAAGAGTAAGATTT
GCTTTATGGAAATCAATTCATTAATAAAAAATGATATTCAAGTTGCAATACCATTTCACAGTGAAATATTTTGAGTACAATTTTGTTGCT

>23250_23250_3_DMGDH-NMNAT2_DMGDH_chr5_78301096_ENST00000255189_NMNAT2_chr1_183230438_ENST00000287713_length(amino acids)=885AA_BP=795
MLRPGAQLLRGLLLRSCPLQGSPGRPRSVCGREGEEKPPLSAETQWKDRAETVIIGGGCVGVSLAYHLAKAGMKDVVLLEKSELTAGSTW
HAAGLTTYFHPGINLKKIHYDSIKLYEKLEEETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMNK
VLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMRANRIVNAAGFWAREVGKMIGLEHPLIPVQH
QYVVTSTISEVKALKRELPVLRDLEGSYYLRQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLK
KADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIGFGYGIIHAGGVGKYLSDWILHGEPPFDLIELDPNRYGKWTTTQYTEAKARESYG
FNNIVGYPKEERFAGRPTQRVSGLYQRLESKCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKF
NIKGQDSIRLLDHLFANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSELHDLRWIEEEAVKGGYDVEIKNITDELGVL
GVAGPQARKVLQKLTSEDLSDDVFKFLQTKSLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRL
EKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVCLTLATDDVDPEGNESIWYNGKMEVIVGDFGIVVVPR

--------------------------------------------------------------
>23250_23250_4_DMGDH-NMNAT2_DMGDH_chr5_78301096_ENST00000255189_NMNAT2_chr1_183230438_ENST00000294868_length(transcript)=7091nt_BP=2414nt
GCGCCTGCGCCCTCGGCCTCGGCCTAGTCATGCTCCGTCCCGGCGCGCAGCTGCTGCGGGGCCTCCTGCTGCGGAGCTGCCCGCTGCAGG
GCTCCCCCGGGCGCCCGCGCTCTGTCTGCGGCCGGGAAGGAGAGGAAAAACCACCCTTATCTGCAGAAACACAATGGAAAGACAGAGCAG
AAACAGTGATAATTGGAGGTGGCTGTGTTGGTGTGAGTCTGGCTTATCACCTGGCCAAAGCAGGGATGAAAGATGTGGTCCTGCTGGAGA
AATCAGAGCTCACGGCTGGATCTACCTGGCACGCAGCAGGTTTAACAACTTACTTTCATCCTGGAATAAACTTGAAGAAAATACATTATG
ATAGCATCAAACTTTATGAGAAACTGGAAGAAGAAACTGGTCAGGTGGTGGGATTCCATCAGCCAGGTAGTATCAGACTTGCTACCACCC
CTGTAAGGGTAGATGAATTTAAATATCAAATGACTCGGACTGGCTGGCATGCAACAGAACAGTATCTCATTGAACCTGAAAAAATTCAAG
AGATGTTCCCTTTACTCAACATGAATAAGGTTTTAGCTGGATTGTATAATCCTGGAGATGGTCACATTGATCCTTATTCTCTAACTATGG
CACTGGCTGCTGGGGCTAGGAAATGTGGTGCCCTTTTAAAATATCCTGCACCAGTAACTTCTCTGAAAGCCAGGTCAGATGGAACATGGG
ACGTTGAAACACCACAGGGGTCTATGAGAGCAAATAGAATTGTGAATGCTGCAGGATTTTGGGCTCGTGAAGTAGGTAAAATGATTGGAC
TAGAACATCCTCTCATTCCGGTTCAACATCAATATGTTGTTACATCGACTATATCTGAAGTGAAAGCTTTGAAACGAGAACTGCCTGTGC
TCCGTGACCTGGAAGGATCATATTATCTCCGACAGGAAAGGGATGGGCTTTTGTTTGGTCCATATGAAAGTCAAGAGAAAATGAAAGTTC
AGGACTCCTGGGTCACCAATGGAGTTCCTCCAGGTTTTGGAAAGGAACTCTTTGAGTCTGATCTAGATCGAATCATGGAACACATCAAAG
CTGCCATGGAAATGGTTCCTGTCTTGAAAAAGGCTGACATCATCAATGTTGTCAATGGTCCTATCACGTATTCTCCTGACATTCTGCCTA
TGGTGGGGCCCCATCAGGGGGTCAGAAACTACTGGGTGGCTATAGGCTTTGGATATGGCATAATCCACGCTGGTGGGGTAGGGAAATATC
TCAGTGACTGGATCCTGCATGGAGAACCTCCTTTTGATCTGATAGAATTGGATCCTAATCGCTATGGCAAATGGACAACAACCCAGTACA
CTGAGGCCAAAGCAAGAGAATCATATGGATTCAACAATATTGTTGGTTATCCTAAAGAAGAACGGTTTGCTGGGAGGCCGACTCAACGAG
TCAGTGGGCTCTATCAAAGGCTGGAGTCTAAGTGTTCCATGGGGTTCCATGCTGGCTGGGAGCAGCCGCACTGGTTCTACAAACCAGGCC
AGGACACTCAGTACAGGCCAAGTTTTCGCCGCACAAACTGGTTTGAGCCTGTGGGCTCGGAGTATAAACAGGTTATGCAAAGAGTAGCGG
TAACTGACCTATCACCATTTGGCAAGTTTAACATCAAAGGCCAAGATTCCATTAGACTACTGGACCATCTCTTTGCAAATGTCATTCCAA
AGGTGGGTTTTACAAATATAAGTCACATGTTAACACCCAAGGGTCGAGTGTATGCTGAGCTGACTGTTTCTCACCAATCTCCTGGGGAGT
TTCTTTTAATTACTGGCTCTGGATCAGAACTTCATGATCTTAGATGGATTGAAGAAGAAGCAGTCAAAGGTGGATATGATGTTGAAATTA
AAAACATAACTGATGAGCTTGGAGTTCTTGGAGTTGCTGGGCCACAGGCAAGAAAGGTCCTTCAGAAACTGACCTCTGAAGATCTTAGTG
ATGATGTTTTCAAGTTTCTTCAAACCAAGTCCTTAAAGGTTTCCAACATTCCTGTCACTGCTATTAGGATATCTTATACTGGTGAGCTGG
GTTGGGAGCTGTATCACAGAAGAGAAGATTCTGTGGCGCTGTATGACGCTATCATGAATGCAGGCCAGGAGGAGGGAATCGACAATTTTG
GAACCTATGCCATGAATGCCTTACGCCTGGAGAAAGCCTTCAGAGCCTGGGGGTTAGAGATGAACTGTGATACAAATCCTTTGGAAGCTG
GACTGGAATATTTTGTGAAGTTAAATAAGCCAGCAGACTTCATAGGAAAGCAAGCACTGAAACAGATTAAAGCCAAGGGGCTGAAACGAA
GACTGGTCTGCCTCACCTTGGCAACGGATGATGTTGATCCAGAGGGAAATGAAAGCATCTGGTACAATGGCAAGATGGAGGTGATTGTTG
GTGACTTTGGGATTGTGGTGGTGCCCCGGGATGCAGCCGACACAGACCGAATCATGAATCACTCCTCAATACTCCGCAAATACAAAAACA
ACATCATGGTGGTGAAGGATGACATCAACCATCCCATGTCTGTTGTCAGCTCAACCAAGAGCAGGCTGGCCCTGCAGCATGGGGACGGCC
ATGTTGTGGATTACCTGTCCCAGCCGGTCATCGACTACATCCTCAAAAGCCAGCTGTACATCAATGCCTCCGGCTAGCAGCCCCTCGTCC
TCCGGCAACACAATGGCCCCTCCATCTTTGTCAGCCCCCTGTTTCTCTCCTGCCTCTCTGTTTCTCCATCTCCTCGTCTTGACTGTTTTC
CCTACTTGCTGACTTAACCCCCCATAGTGTGGGGGACCTGCAGAGAACCATGGCATTCCCTATTCCACAGTCATCTTTGGACAGACTTTC
CTCTAGTCTCCGGGTTGGGGGTGGGTGAGGGAATGGGGTGGGAGTCGGGGGAAGTGCAGTCCTTGGAGATGTACTGGTGTCCGTCTCCCA
GCATGCTCTAGAGAGGCGGCTCTGGTGCCCATCCTCCCAGCACGCTCTGGGGAGGCGGCTCTGGTGCCCATCCTCCCAGCATGCTCTAGA
GAGGCGGCTCTGGTGCCCCTCCTCCCAGCATGCTCTGGGGAGGCGGCTCTGGCTCTTGCCTTCCCAGCATGCCCTTTACTACAAAGGGCT
ATTTTTCTTTTCTTTCTTTTGTTTATTTATTTTTCTTTGTTCACTCCCTGTAGAACTTGGATGAAATCAGTGTCCATGGTTCTTTATGTT
TGTAGTCTTGATGTGCTCCTGTGGTATTACTTCCCCTCTGATAGGACATTGTAGCCAGCCTCAGCACTCAGTGAGTTCATCAGGGCCACA
CCCAGTAGAGAAGGCCAAGCAACCTCCACTTCTTCAGCACCACACACACGCACACACACACACACGCACACATGCGTGTGCACCCGCGCA
CGCACATACACACACACATATAGCAGTAGCAGCAGCAGCAGCAGCAGCAGCAACCTTTGATCAGGAGTGAGATTTTCGGGTTCTGAAACC
TGGGACACGAGTCTGTGAATAGTCGGTTTTCTCAGAATAATTTGAATCTGTTTTCTTAGTTTCAAATGACCATTTCCCTGATGCTCTGAG
CTTATGATCACACAGAGCCAGTCCATCCTCATTTCCTGGTGGCATCTGTTCATTTACCTTTGTGGACTGTAGCTGATGGCACAGTGCGGG
TTCCCTACCAGCCAGGGGTTTCCAAGGGACCTTTGGAGGCCATGCTTAGACACATTCCTGTACCTGAGAACAACCACATAGGCAGGACCA
GATCCACATCGTGCAGTCGTGTCATAAAAAAACAAAACAAAACAAAAAAACACTAGGAGTCCACTCAACCCTGGAGGTCTTTGCTAATTG
GAATTATGTATTGTCTGTTGGGCTGGGAAATGTCTCTTTCATATTGTAAGTCCAGGATGAACTAGGAGAAAGCAATTTGTTGCCCTGATG
ATAACTGATGATTTTCACCCTCTCTAGCTGAGGTAACTCAGACAGTGCATGAGGTCAGTTTCTTCTTGAGAAGCAGTGCCTTGGTCTTGT
TTCTGTGGTTGGTTCTAGCCCCTGCAGAGCCTGGGAGCTGCAGGAACTGTCTGAGAAAATCTCCCTAATAGGGGAGTGGGTTCCCAGAAG
GGAGATCTGGGAGGGGTCAGGAGCCACTAAGTTGCTTCACTCCTTTTTTCTCTAATTTTCTACCTTCCTCTCTGTTCCTGCAGACAGTTT
TGCCAGCTTTGCTTCTGGTTACTAGGGTCTCATGCGTGTCCTGCTTGGAGAGCCATAAGGAAATTGCTGTCTTGTGCTTTGTGTCTCTCA
TCCAGTCTCTGGCTCTTGGGATTCTGGTCTTTGAGAAATAGTCCCTGAGTATTAGGATACTTTTATCAAAATCTAGTACCAGCTACGGCC
AGAAAGGGCCAGGTGGGACCTGAAAGCAAAGACAATGTTCTTTACCACACGTTTCACATCTGCAACATCCTTCAATTGCGGGAAAAGGAA
CTTGATTTAACAGAAGAACATGGTAGAGCAGCATCCAGAAAGTCTGTTATTCCTCTTGGATTTTTTGAAATAATCTTCAGAGGAAGGAAG
GAAAATCCTATTTTGGGGTATCAGTGTTTGACTAGGGATCATGAAATAATAAACTGAAAAAAACTTTAGAGTTCAGTTGATCCAACACTT
TCCTTTAAAAGTTGAGGGAGCAGAGGCCCATGGGATTAAATGGCTGGTCCAGGTCAGCCAGCAGGTGTAGGGCCTGACAAGAACATATTG
TTTCCCTGACCCCTAGGCCGTCACACCACACCCTCCATTTCCTCATGTTGCTGACCAGGTGCCCATATGATTTCTACACTTCCCAAGCCT
TACCCTGGCATCTTTCTTTTAAATTATATCTGTCCCAGGTGCTCTCCACACATAGGATGGTAATGCCAGTCCCAGGGGAGGGTGTGATAG
TAAGGAAGGCCACTGTTAGGTTTCCTTTAGAAATAAAGAGATCTCAGCAGCTTGGAAGAAATCCCAGAAGCGGACTCCATCAATCCAAGA
AAGAGTTGCTTTGTGGAAGGTGAAGGAAGACCCACAGAGTGCTCAGGATGATGCTATTGCTGGAGAGCGAAAGATGGAACAGCCTTGTCC
AGGCAGAACAGTCATAAGCCAGGAAATGAAACAAAGGAAAACAGGTGCCTGAATTTCCTGGGGAAACATGGCTTGTTTAAGGACTTGGAG
TTATGGATGGAATTTATGGGACCCACGTGAGCAGACCTGAGGAAGGCTCGATTTCTTTTGTTTCTTGGTCCACTCTGTCACTCTGCTCTG
GTCAAGCCCCATTTGGTCTACAGCCCATGAGAAGGAATGAGGCTGGTTCTGCACTCTCAGCATGCAGTCCGAAAGCATGTGGGAGTGGGG
AGGGAAAGTGAGATGAATTAAGACAAAGAACAGGTGCCATAGAAGTAGATTTCTAGGAATGAAGTGGGGCAGATCTTATCTTTGTGGATT
ACAGGCACTGTACTAAAAACAGGTTTCCTATTTAATATAAAAAGAAAGTGAATCTTCTTTTGGATAGAATCATCCATTCCCATCGCCGCA
CCCCCTACCCCCCAAACACACACACACACACACACACACACACACACACACACACACACACACACGCCCTACTCTTCATTTGCTAGGGGA
AGGTCACAGCACAACTAAATCCAGGACAGGACATTGTGACCATGACCCAGCCACAGTCAATACCAGAAAGATGATTCAGAGTCTGAAGTG
GTGCCCCAGGTGCCAACAGGATAACCTCTACCCCCCGACTTTGTCTCTGGGGTCCTGTTCCTTCCTGCAAAGCCCAATCCAAGACTGGCA
TGGCTCAGAGGTTGTGAGAAAGGCATGGACTGGAACAATCATGTCCAGAGGGGTCTGGAGCTTTGTTTCCTGTTCACCAGCAAAAAATGT
CTCTCCCATTTTTCTGAAAGTGGCTGATGTAAGAACAGGCAGAAGGAAAACCCTTTTTGTCAATAACTCTGTCCTTAAGGAATGGTCCTC
TGGGAGGGCTGTGCTGCTAGTGGGTACCTCAGTCACACACCCCCAACCCCAGGCAGCCTCTAGAGCCTTCTTGCTTTCATTTTCCTTGAA
TGTACATAGGAACAAGGGGGAAAGTCTCTTACTGAAGTGCCTGAAACCCAAAGCTAGAGCTTCTAGAGACGCCGTTCTTCCTGTCTCAGC
TTGGCCAGCCTTTCAACAATGTTCTCTAGTTTCAAGCTCCAGCTTCTCAGAAAGAATTAAAGAACTTGCTGTTCAAATTAAGTAGAAAGT
GAGACTCAATAATAACTGAACTACAGCAAAAGGCAGAGAATTACAGGGAGAAAAAACTTGTACTTACCAGCCCAATTCTACTCTCCTCAA
ACTGACACACACACACACACACACACACACACACACACACACACACTCTTTTAGGGGACTAAGAGAGAGAAGCATGTTATTACATTTTAC
TCATCCAAACAGTAATGCAAAAATAAAACGGTAGAATATGAAAAGCTCAGGATCTCTCCCAAGGCTACCTACTGCAGGAGGGCCAACAGG
TGAGATGGGAAGAATGGAAACAGGGACCGATTTTGTAGCTCATACAATTAGGACACCTTAGGAATAGCATTGTAGTAATGGTGATGAATA
TGCTCTGCCAAATTCATCCAGTCTGCACCATCTTATAGCTGCCCAGCACACTCGACTGTTCATGTGGTCTCTTTGTAGTGTGAGTTTGGA
GTGTCCTATTAGCCTGTTCTGGTTAGGAATGAGTTAACGGCTCTTTCCCTCAACCTTAGTCTAGTCCCAGGGCTGAGGATTCAGCTGGAT
CCACATGGTCTTGAGGGTTGGCATGAGGAGGGGGAAGCTTTTTTGAATCGCTTTTTGATCACATAATCTGCCATTTTAAGAGTAAGATTT
GCTTTATGGAAATCAATTCATTAATAAAAAATGATATTCAAGTTGCAATACCATTTCACAGTGAAATATTTTGAGTACAATTTTGTTGCT

>23250_23250_4_DMGDH-NMNAT2_DMGDH_chr5_78301096_ENST00000255189_NMNAT2_chr1_183230438_ENST00000294868_length(amino acids)=885AA_BP=795
MLRPGAQLLRGLLLRSCPLQGSPGRPRSVCGREGEEKPPLSAETQWKDRAETVIIGGGCVGVSLAYHLAKAGMKDVVLLEKSELTAGSTW
HAAGLTTYFHPGINLKKIHYDSIKLYEKLEEETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMNK
VLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMRANRIVNAAGFWAREVGKMIGLEHPLIPVQH
QYVVTSTISEVKALKRELPVLRDLEGSYYLRQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLK
KADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIGFGYGIIHAGGVGKYLSDWILHGEPPFDLIELDPNRYGKWTTTQYTEAKARESYG
FNNIVGYPKEERFAGRPTQRVSGLYQRLESKCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKF
NIKGQDSIRLLDHLFANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSELHDLRWIEEEAVKGGYDVEIKNITDELGVL
GVAGPQARKVLQKLTSEDLSDDVFKFLQTKSLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRL
EKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVCLTLATDDVDPEGNESIWYNGKMEVIVGDFGIVVVPR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DMGDH-NMNAT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DMGDH-NMNAT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for DMGDH-NMNAT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource