Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DMKN-IPO5 (FusionGDB2 ID:23251)

Fusion Gene Summary for DMKN-IPO5

Fusion gene summary

Fusion gene information	Fusion gene name: DMKN-IPO5
	Fusion gene ID: 23251
		Hgene	Tgene
	Gene symbol	DMKN	IPO5
	Gene ID	93099	3843
	Gene name	dermokine	importin 5
	Synonyms	UNQ729\|ZD52F10	IMB3\|KPNB3\|Pse1\|RANBP5\|imp5
	Cytomap	19q13.12	13q32.2
	Type of gene	protein-coding	protein-coding
	Description	dermokineepidermis-specific secreted protein SK30/SK89	importin-5RAN binding protein 5Ran_GTP binding protein 5importin beta-3 subunitimportin subunit beta-3karyopherin (importin) beta 3karyopherin beta-3ran-binding protein 5
	Modification date	20200313	20200313
	UniProtAcc	Q6E0U4	O00410
	Ensembl transtripts involved in fusion gene	ENST00000339686, ENST00000392206, ENST00000402589, ENST00000408915, ENST00000414866, ENST00000418261, ENST00000419602, ENST00000424570, ENST00000429837, ENST00000436012, ENST00000440396, ENST00000443640, ENST00000447113, ENST00000451297, ENST00000458071, ENST00000461300, ENST00000462126, ENST00000467637, ENST00000472252, ENST00000474928, ENST00000480502, ENST00000488892, ENST00000492341, ENST00000602781,	ENST00000261574, ENST00000490680, ENST00000493492, ENST00000539640,
Fusion gene scores	* DoF score	2 X 2 X 2=8	10 X 13 X 4=520
	# samples	2	13
	** MAII score	log2(2/8*10)=1.32192809488736	log2(13/520*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DMKN [Title/Abstract] AND IPO5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DMKN(35988341)-IPO5(98628569), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	IPO5	GO:0006610	ribosomal protein import into nucleus	9687515

Fusion gene breakpoints across DMKN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across IPO5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	FN173501	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+

Top

Fusion Gene ORF analysis for DMKN-IPO5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000339686	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000339686	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000339686	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000339686	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000392206	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000392206	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000392206	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000392206	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000402589	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000402589	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000402589	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000402589	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000408915	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000408915	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000408915	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000408915	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000414866	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000414866	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000414866	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000414866	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000418261	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000418261	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000418261	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000418261	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000419602	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000419602	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000419602	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000419602	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000424570	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000424570	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000424570	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000424570	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000429837	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000429837	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000429837	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000429837	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000436012	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000436012	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000436012	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000436012	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000440396	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000440396	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000440396	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000440396	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000443640	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000443640	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000443640	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000443640	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000447113	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000447113	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000447113	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000447113	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000451297	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000451297	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000451297	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000451297	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000458071	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000458071	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000458071	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000458071	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000461300	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000461300	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000461300	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000461300	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000462126	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000462126	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000462126	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000462126	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000467637	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000467637	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000467637	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000467637	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000472252	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000472252	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000472252	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000472252	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000474928	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000474928	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000474928	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000474928	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000480502	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000480502	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000480502	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000480502	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000488892	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000488892	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000488892	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000488892	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000492341	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000492341	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000492341	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000492341	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000602781	ENST00000261574	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000602781	ENST00000490680	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000602781	ENST00000493492	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+
intron-intron	ENST00000602781	ENST00000539640	DMKN	chr19	35988341	-	IPO5	chr13	98628569	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for DMKN-IPO5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for DMKN-IPO5

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:35988341/:98628569)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DMKN Q6E0U4	IPO5 O00410
FUNCTION: May act as a soluble regulator of keratinocyte differentiation. {ECO:0000305}.	FUNCTION: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000250\|UniProtKB:Q8BKC5, ECO:0000269\|PubMed:9687515}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for DMKN-IPO5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for DMKN-IPO5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for DMKN-IPO5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for DMKN-IPO5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source