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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DMTF1-RUNDC3B (FusionGDB2 ID:23263)

Fusion Gene Summary for DMTF1-RUNDC3B

check button Fusion gene summary
Fusion gene informationFusion gene name: DMTF1-RUNDC3B
Fusion gene ID: 23263
HgeneTgene
Gene symbol

DMTF1

RUNDC3B

Gene ID

9988

154661

Gene namecyclin D binding myb like transcription factor 1RUN domain containing 3B
SynonymsDMP1|DMTF|MRUL|hDMP1RPIB9|RPIP9
Cytomap

7q21.12

7q21.12

Type of geneprotein-codingprotein-coding
Descriptioncyclin-D-binding Myb-like transcription factor 1cyclin D-binding Myb-like proteincyclin-D-interacting Myb-like protein 1hDMTF1RUN domain-containing protein 3BRPIP-9Rap2 binding protein 9Rap2-interacting protein 9rap2-binding protein 9
Modification date2020031320200320
UniProtAcc

Q9Y222

.
Ensembl transtripts involved in fusion geneENST00000331242, ENST00000394702, 
ENST00000411766, ENST00000413276, 
ENST00000432937, ENST00000394703, 
ENST00000414194, ENST00000580710, 
ENST00000338056, ENST00000394654, 
ENST00000493037, ENST00000496000, 
Fusion gene scores* DoF score5 X 5 X 5=1256 X 6 X 4=144
# samples 56
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DMTF1 [Title/Abstract] AND RUNDC3B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDMTF1(86781871)-RUNDC3B(87369107), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DMTF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RUNDC3B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0DO-01BDMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+


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Fusion Gene ORF analysis for DMTF1-RUNDC3B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000331242ENST00000338056DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
5UTR-3CDSENST00000331242ENST00000394654DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
5UTR-3CDSENST00000331242ENST00000493037DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
5UTR-3CDSENST00000394702ENST00000338056DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
5UTR-3CDSENST00000394702ENST00000394654DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
5UTR-3CDSENST00000394702ENST00000493037DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
5UTR-3CDSENST00000411766ENST00000338056DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
5UTR-3CDSENST00000411766ENST00000394654DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
5UTR-3CDSENST00000411766ENST00000493037DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
5UTR-3CDSENST00000413276ENST00000338056DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
5UTR-3CDSENST00000413276ENST00000394654DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
5UTR-3CDSENST00000413276ENST00000493037DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
5UTR-3CDSENST00000432937ENST00000338056DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
5UTR-3CDSENST00000432937ENST00000394654DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
5UTR-3CDSENST00000432937ENST00000493037DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
5UTR-3UTRENST00000331242ENST00000496000DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
5UTR-3UTRENST00000394702ENST00000496000DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
5UTR-3UTRENST00000411766ENST00000496000DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
5UTR-3UTRENST00000413276ENST00000496000DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
5UTR-3UTRENST00000432937ENST00000496000DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
intron-3CDSENST00000394703ENST00000338056DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
intron-3CDSENST00000394703ENST00000394654DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
intron-3CDSENST00000394703ENST00000493037DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
intron-3CDSENST00000414194ENST00000338056DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
intron-3CDSENST00000414194ENST00000394654DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
intron-3CDSENST00000414194ENST00000493037DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
intron-3CDSENST00000580710ENST00000338056DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
intron-3CDSENST00000580710ENST00000394654DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
intron-3CDSENST00000580710ENST00000493037DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
intron-3UTRENST00000394703ENST00000496000DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
intron-3UTRENST00000414194ENST00000496000DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+
intron-3UTRENST00000580710ENST00000496000DMTF1chr7

86781871

+RUNDC3Bchr7

87369107

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DMTF1-RUNDC3B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DMTF1chr786781871+RUNDC3Bchr787369106+0.0029213420.99707866
DMTF1chr786781871+RUNDC3Bchr787369106+0.0029213420.99707866

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DMTF1-RUNDC3B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:86781871/:87369107)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DMTF1

Q9Y222

.
FUNCTION: Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1. {ECO:0000250, ECO:0000269|PubMed:12917399}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DMTF1-RUNDC3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DMTF1-RUNDC3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DMTF1-RUNDC3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DMTF1-RUNDC3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource