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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DNAH14-EPHX1 (FusionGDB2 ID:23341)

Fusion Gene Summary for DNAH14-EPHX1

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAH14-EPHX1
Fusion gene ID: 23341
HgeneTgene
Gene symbol

DNAH14

EPHX1

Gene ID

127602

2052

Gene namedynein axonemal heavy chain 14epoxide hydrolase 1
SynonymsC1orf67|Dnahc14|HL-18|HL18EPHX|EPOX|HYL1|MEH
Cytomap

1q42.12

1q42.12

Type of geneprotein-codingprotein-coding
Descriptiondynein heavy chain 14, axonemalaxonemal beta dynein heavy chain 14ciliary dynein heavy chain 14dynein, axonemal, heavy polypeptide 14epoxide hydrolase 1epoxide hydrataseepoxide hydrolase 1 microsomalepoxide hydrolase 1, microsomal (xenobiotic)
Modification date2020031320200313
UniProtAcc

Q0VDD8

P07099

Ensembl transtripts involved in fusion geneENST00000498360, ENST00000445597, 
ENST00000366849, ENST00000366850, 
ENST00000400952, ENST00000430092, 
ENST00000366848, ENST00000439375, 
ENST00000272167, ENST00000366837, 
ENST00000467015, 
Fusion gene scores* DoF score8 X 6 X 4=19212 X 11 X 7=924
# samples 713
** MAII scorelog2(7/192*10)=-1.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/924*10)=-2.8293812283876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNAH14 [Title/Abstract] AND EPHX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNAH14(225117537)-EPHX1(226016426), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEPHX1

GO:0097176

epoxide metabolic process

22798687


check buttonFusion gene breakpoints across DNAH14 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across EPHX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-J2-A4AD-01ADNAH14chr1

225117537

+EPHX1chr1

226016426

+


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Fusion Gene ORF analysis for DNAH14-EPHX1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000498360ENST00000272167DNAH14chr1

225117537

+EPHX1chr1

226016426

+
3UTR-5UTRENST00000498360ENST00000366837DNAH14chr1

225117537

+EPHX1chr1

226016426

+
3UTR-intronENST00000498360ENST00000467015DNAH14chr1

225117537

+EPHX1chr1

226016426

+
5CDS-5UTRENST00000445597ENST00000272167DNAH14chr1

225117537

+EPHX1chr1

226016426

+
5CDS-5UTRENST00000445597ENST00000366837DNAH14chr1

225117537

+EPHX1chr1

226016426

+
5CDS-intronENST00000445597ENST00000467015DNAH14chr1

225117537

+EPHX1chr1

226016426

+
5UTR-5UTRENST00000366849ENST00000272167DNAH14chr1

225117537

+EPHX1chr1

226016426

+
5UTR-5UTRENST00000366849ENST00000366837DNAH14chr1

225117537

+EPHX1chr1

226016426

+
5UTR-5UTRENST00000366850ENST00000272167DNAH14chr1

225117537

+EPHX1chr1

226016426

+
5UTR-5UTRENST00000366850ENST00000366837DNAH14chr1

225117537

+EPHX1chr1

226016426

+
5UTR-5UTRENST00000400952ENST00000272167DNAH14chr1

225117537

+EPHX1chr1

226016426

+
5UTR-5UTRENST00000400952ENST00000366837DNAH14chr1

225117537

+EPHX1chr1

226016426

+
5UTR-5UTRENST00000430092ENST00000272167DNAH14chr1

225117537

+EPHX1chr1

226016426

+
5UTR-5UTRENST00000430092ENST00000366837DNAH14chr1

225117537

+EPHX1chr1

226016426

+
5UTR-intronENST00000366849ENST00000467015DNAH14chr1

225117537

+EPHX1chr1

226016426

+
5UTR-intronENST00000366850ENST00000467015DNAH14chr1

225117537

+EPHX1chr1

226016426

+
5UTR-intronENST00000400952ENST00000467015DNAH14chr1

225117537

+EPHX1chr1

226016426

+
5UTR-intronENST00000430092ENST00000467015DNAH14chr1

225117537

+EPHX1chr1

226016426

+
intron-5UTRENST00000366848ENST00000272167DNAH14chr1

225117537

+EPHX1chr1

226016426

+
intron-5UTRENST00000366848ENST00000366837DNAH14chr1

225117537

+EPHX1chr1

226016426

+
intron-5UTRENST00000439375ENST00000272167DNAH14chr1

225117537

+EPHX1chr1

226016426

+
intron-5UTRENST00000439375ENST00000366837DNAH14chr1

225117537

+EPHX1chr1

226016426

+
intron-intronENST00000366848ENST00000467015DNAH14chr1

225117537

+EPHX1chr1

226016426

+
intron-intronENST00000439375ENST00000467015DNAH14chr1

225117537

+EPHX1chr1

226016426

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DNAH14-EPHX1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DNAH14chr1225117537+EPHX1chr1226016425+2.29E-070.99999976
DNAH14chr1225117537+EPHX1chr1226016425+2.29E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DNAH14-EPHX1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:225117537/:226016426)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAH14

Q0VDD8

EPHX1

P07099

FUNCTION: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). {ECO:0000250}.FUNCTION: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids (PubMed:22798687). Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (PubMed:24958911). {ECO:0000250|UniProtKB:P07687, ECO:0000269|PubMed:22798687, ECO:0000269|PubMed:24958911}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DNAH14-EPHX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DNAH14-EPHX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DNAH14-EPHX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DNAH14-EPHX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource