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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DNAH3-SDF2 (FusionGDB2 ID:23366)

Fusion Gene Summary for DNAH3-SDF2

Fusion gene summary

Fusion gene information	Fusion gene name: DNAH3-SDF2
	Fusion gene ID: 23366
		Hgene	Tgene
	Gene symbol	DNAH3	SDF2
	Gene ID	55567	6388
	Gene name	dynein axonemal heavy chain 3	stromal cell derived factor 2
	Synonyms	DNAHC3-B\|DNAHC3B\|HDHC8\|HEL-36\|HSADHC3	-
	Cytomap	16p12.3	17q11.2
	Type of gene	protein-coding	protein-coding
	Description	dynein heavy chain 3, axonemalaxonemal beta dynein heavy chain 3axonemal dynein, heavy chainciliary dynein heavy chain 3dynein, axonemal, heavy polypeptide 3epididymis luminal protein 36	stromal cell-derived factor 2SDF-2
	Modification date	20200313	20200313
	UniProtAcc	Q8TD57	.
	Ensembl transtripts involved in fusion gene	ENST00000415178, ENST00000261383, ENST00000575491,	ENST00000247020, ENST00000592250,
Fusion gene scores	* DoF score	7 X 7 X 2=98	9 X 4 X 8=288
	# samples	7	10
	** MAII score	log2(7/98*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DNAH3 [Title/Abstract] AND SDF2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DNAH3(21030946)-SDF2(26982501), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across DNAH3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SDF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CD-8525-01A	DNAH3	chr16	21030946	-	SDF2	chr17	26982501	-

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Fusion Gene ORF analysis for DNAH3-SDF2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000415178	ENST00000247020	DNAH3	chr16	21030946	-	SDF2	chr17	26982501	-
3UTR-5UTR	ENST00000415178	ENST00000592250	DNAH3	chr16	21030946	-	SDF2	chr17	26982501	-
5CDS-5UTR	ENST00000261383	ENST00000592250	DNAH3	chr16	21030946	-	SDF2	chr17	26982501	-
In-frame	ENST00000261383	ENST00000247020	DNAH3	chr16	21030946	-	SDF2	chr17	26982501	-
intron-3CDS	ENST00000575491	ENST00000247020	DNAH3	chr16	21030946	-	SDF2	chr17	26982501	-
intron-5UTR	ENST00000575491	ENST00000592250	DNAH3	chr16	21030946	-	SDF2	chr17	26982501	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000261383

DNAH3

chr16

21030946

ENST00000247020

SDF2

chr17

26982501

7140

6022

6506

2168

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000261383	ENST00000247020	DNAH3	chr16	21030946	-	SDF2	chr17	26982501	-	0.000395364	0.99960464

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Fusion Genomic Features for DNAH3-SDF2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DNAH3-SDF2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:21030946/chr17:26982501)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DNAH3 Q8TD57	.
FUNCTION: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000261383

785_852

2007

4117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000415178

785_852

1964

3012.6666666666665

Coiled coil

Ontology_term=ECO:0000255

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000261383

1429_1436

2007

4117.0

Nucleotide binding

ATP

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000261383

1710_1717

2007

4117.0

Nucleotide binding

ATP

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000415178

1429_1436

1964

3012.6666666666665

Nucleotide binding

ATP

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000415178

1710_1717

1964

3012.6666666666665

Nucleotide binding

ATP

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000261383

1391_1612

2007

4117.0

Region

AAA 1

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000261383

1672_1903

2007

4117.0

Region

AAA 2

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000261383

1_1390

2007

4117.0

Region

Stem

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000415178

1391_1612

1964

3012.6666666666665

Region

AAA 1

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000415178

1672_1903

1964

3012.6666666666665

Region

AAA 2

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000415178

1_1390

1964

3012.6666666666665

Region

Stem

Tgene

SDF2

chr16:21030946

chr17:26982501

ENST00000247020

139_193

212.0

Domain

MIR 3

Tgene

SDF2

chr16:21030946

chr17:26982501

ENST00000247020

83_138

212.0

Domain

MIR 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000261383

2074_2081

2007

4117.0

Nucleotide binding

ATP

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000261383

2434_2441

2007

4117.0

Nucleotide binding

ATP

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000415178

2074_2081

1964

3012.6666666666665

Nucleotide binding

ATP

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000415178

2434_2441

1964

3012.6666666666665

Nucleotide binding

ATP

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000261383

2036_2284

2007

4117.0

Region

AAA 3

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000261383

2395_2646

2007

4117.0

Region

AAA 4

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000261383

2661_2960

2007

4117.0

Region

Stalk

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000261383

3045_3275

2007

4117.0

Region

AAA 5

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000261383

3488_3712

2007

4117.0

Region

AAA 6

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000415178

2036_2284

1964

3012.6666666666665

Region

AAA 3

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000415178

2395_2646

1964

3012.6666666666665

Region

AAA 4

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000415178

2661_2960

1964

3012.6666666666665

Region

Stalk

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000415178

3045_3275

1964

3012.6666666666665

Region

AAA 5

Hgene

DNAH3

chr16:21030946

chr17:26982501

ENST00000415178

3488_3712

1964

3012.6666666666665

Region

AAA 6

Tgene

SDF2

chr16:21030946

chr17:26982501

ENST00000247020

21_75

212.0

Domain

MIR 1

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Fusion Gene Sequence for DNAH3-SDF2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>23366_23366_1_DNAH3-SDF2_DNAH3_chr16_21030946_ENST00000261383_SDF2_chr17_26982501_ENST00000247020_length(transcript)=7140nt_BP=6022nt
ATGGGAGCTACAGGGCGCCTCGAGCTCACACTGGCCGCCCCTCCCCATCCGGGCCCAGCCTTTCAGCGTTCAAAAGCCAGGGAGACCCAA
GGAGAGGAGGAAGGGAGTGAAATGCAGATCGCCAAAAGTGACTCCATACATCACATGAGCCACTCCCAGGGGCAGCCAGAGCTGCCTCCT
CTGCCTGCTTCTGCTAATGAGGAACCGTCTGGACTCTATCAGACTGTCATGTCACACAGCTTTTACCCGCCCTTGATGCAACGCACGTCA
TGGACCTTGGCTGCACCCTTCAAAGAACAGCATCACCACCGTGGACCCAGTGATTCCATCGCCAACAACTACTCCTTGATGGCCCAGGAC
CTGAAGCTGAAAGATCTGCTGAAGGTCTACCAACCGGCCACCATCAGTGTCCCTAGGGACAGGACCGGTCAGGGGCTGCCATCATCAGGA
AATAGAAGCTCATCAGAGCCCATGAGGAAAAAAACGAAGTTTTCCTCCAGAAACAAAGAGGATTCCACTAGGATCAAGTTGGCCTTCAAG
ACGTCAATCTTCTCACCCATGAAGAAGGAGGTAAAGACATCTTTGACGTTCCCAGGAAGCAGACCAATGAGTCCAGAACAGCAGCTCGAT
GTCATGTTACAGCAGGAGATGGAAATGGAAAGTAAAGAAAAGAAGCCATCTGAATCGGACCTGGAGAGATACTATTACTATCTGACCAAT
GGAATTCGCAAAGACATGATTGCCCCTGAGGAGGGTGAAGTGATGGTTCGGATTTCAAAGCTGATTTCTAACACGCTGCTGACGAGTCCC
TTCCTGGAGCCCCTGATGGTGGTCCTCGTGCAGGAGAAGGAGAATGACTATTACTGTAGCCTCATGAAAAGCATCGTTGATTACATCCTC
ATGGACCCAATGGAGAGAAAACGGCTCTTTATTGAGAGCATCCCCCGCTTGTTTCCTCAAAGAGTGATCCGGGCCCCTGTGCCCTGGCAC
AGTGTCTACAGGAGCGCCAAGAAGTGGAACGAGGAGCATCTGCACACGGTGAACCCCATGATGCTCAGGCTGAAAGAACTGTGGTTTGCA
GAATTCAGAGACCTCAGGTTTGTTCGAACAGCAGAAATACTAGCGGGAAAATTGCCTCTGCAGCCTCAGGAATTTTGGGATGTGATCCAG
AAACACTGCCTGGAGGCACACCAGACTCTTCTCAACAAGTGGATCCCCACCTGCGCCCAGCTTTTTACCTCACGGAAGGAGCACTGGATT
CATTTTGCTCCCAAGAGCAACTATGACTCAAGTCGAAACATTGAGGAATATTTTGCTTCTGTGGCATCATTCATGTCGCTGCAGCTTAGG
GAGCTGGTCATTAAGTCACTTGAGGACCTCGTTTCCCTTTTCATGATACACAAAGATGGGAATGATTTTAAGGAGCCCTACCAAGAGATG
AAGTTTTTCATACCTCAGCTAATCATGATCAAACTTGAAGTCAGTGAACCCATTATTGTCTTCAATCCATCTTTTGATGGCTGCTGGGAA
TTAATACGTGACTCTTTCCTGGAAATTATTAAGAACTCTAATGGGATCCCCAAGCTGAAATACATACCACTTAAGTTCTCCTTCACTGCT
GCTGCTGCTGATCGGCAATGTGTGAAAGCAGCTGAGCCAGGAGAGCCCAGCATGCACGCGGCTGCCACTGCAATGGCAGAGCTGAAAGGA
TATAATCTGCTCCTTGGAACTGTTAACGCAGAAGAAAAACTTGTTTCTGATTTTTTGATTCAAACTTTCAAGGTATTTCAGAAAAATCAA
GTTGGCCCCTGCAAATATTTAAATGTCTACAAAAAGTATGTTGACTTATTGGATAACACGGCAGAGCAAAACATCGCTGCGTTCCTGAAA
GAAAATCATGACATTGATGATTTTGTGACGAAGATCAATGCCATAAAGAAACGGAGAAATGAAATTGCATCCATGAACATCACCGTGCCT
TTAGCCATGTTCTGCCTTGATGCTACGGCCCTAAATCATGATCTCTGTGAGCGAGCTCAAAATCTTAAAGACCATCTGATTCAATTCCAA
GTGGATGTAAACCGAGACACCAATACCAGCATTTGTAATCAGTACAGCCACATCGCAGACAAAGTCAGTGAGGTTCCTGCCAACACTAAG
GAGCTGGTATCCCTCATTGAATTCCTAAAGAAATCCAGTGCTGTCACTGTGTTCAAACTCAGGAGGCAACTTAGAGATGCAAGTGAACGG
CTGGAGTTCCTGATGGACTATGCAGACTTGCCGTACCAGATTGAAGATATCTTTGACAACAGCCGGAACTTGCTCCTTCACAAGAGGGAT
CAGGCAGAAATGGATCTGATTAAAAGATGCTCAGAATTTGAGTTGAGACTTGAGGGCTACCACAGAGAACTGGAAAGTTTTAGGAAGCGC
GAAGTGATGACTACAGAAGAAATGAAGCACAATGTTGAAAAGCTTAATGAGCTTTCAAAGAACCTAAATCGGGCGTTTGCAGAGTTTGAG
TTGATCAATAAGGAGGAAGAGCTATTGGAAAAGGAGAAGAGTACTTACCCTCTTCTGCAGGCCATGCTGAAGAACAAAGTACCTTATGAG
CAGCTGTGGTCGACAGCCTATGAGTTCAGCATCAAGTCAGAGGAATGGATGAATGGACCCCTCTTCTTACTGAATGCTGAGCAAATTGCG
GAGGAGATAGGGAATATGTGGAGGACAACGTATAAACTGATCAAGACCTTGTCTGATGTGCCTGCACCCAGGCGCTTAGCAGAGAATGTG
AAGATCAAGATCGATAAGTTCAAGCAGTACATTCCCATCCTCAGTATTTCCTGCAACCCAGGAATGAAAGACCGACACTGGCAGCAGATC
AGTGAGATTGTTGGCTATGAGATAAAGCCCACCGAAACGACCTGCCTCTCAAATATGCTCGAATTTGGATTCGGCAAATTCGTTGAAAAA
TTGGAGCCCATTGGTGCAGCTGCCAGCAAGGAATACTCTCTGGAGAAAAACTTGGATAGAATGAAGTTGGATTGGGTTAACGTGACGTTC
AGCTTCGTGAAATACAGGGACACTGATACAAACATCTTGTGTGCAATTGATGACATTCAAATGCTACTTGATGATCACGTGATAAAGACC
CAGACCATGTGTGGCTCCCCATTCATCAAACCAATAGAAGCAGAATGCCGGAAATGGGAAGAAAAGCTAATTCGCATACAAGACAATTTG
GATGCCTGGTTGAAATGCCAAGCCACCTGGCTGTACCTGGAACCAATCTTCAGTTCAGAGGACATCATAGCCCAGATGCCAGAAGAGGGG
AGGAAATTTGGCATTGTTGATAGTTACTGGAAATCACTTATGTCCCAAGCGGTGAAAGATAACAGGATTCTGGTGGCAGCCGACCAGCCA
CGGATGGCAGAGAAGCTTCAAGAAGCCAACTTTCTCTTGGAGGACATCCAGAAAGGGCTGAATGATTACTTGGAGAAGAAGAGACTATTC
TTCCCCAGATTCTTCTTCCTATCAAACGATGAGCTGCTGGAAATCTTGTCCGAGACAAAGGACCCTCTCCGAGTGCAGCCGCACTTGAAG
AAGTGCTTTGAAGGAATTGCCAAGCTTGAGTTTACAGACAATCTGGAAATTGTGGGCATGATCAGCTCGGAAAAAGAAACTGTTCCATTC
ATACAGAAAATCTACCCAGCTAATGCCAAGGGCATGGTGGAAAAGTGGCTCCAGCAGGTGGAGCAGATGATGCTGGCCAGTATGCGAGAA
GTCATTGGACTTGGGATTGAAGCATATGTCAAGGTCCCTCGAAATCACTGGGTCTTACAGTGGCCTGGACAGGTGGTTATCTGTGTCTCC
TCCATCTTTTGGACCCAGGAGGTGTCCCAAGCCCTGGCGGAAAATACCTTACTGGATTTTCTGAAAAAGAGCAATGATCAGATTGCGCAG
ATTGTCCAGCTGGTGCGAGGGAAGCTGAGCAGTGGAGCTCGACTCACTCTCGGGGCCCTCACGGTCATCGATGTCCACGCCCGCGACGTG
GTGGCCAAGTTATCTGAGGACAGGGTCTCCGATCTGAATGATTTCCAATGGATCTCACAGCTGCGCTACTACTGGGTGGCCAAGGATGTG
CAGGTGCAGATTATCACCACAGAAGCCTTGTATGGCTATGAGTACCTGGGAAACTCCCCCCGGCTGGTGATCACACCCCTCACCGACCGC
TGCTACAGGACACTGATGGGAGCTTTGAAGCTGAACCTTGGGGGTGCTCCAGAGGGTCCAGCTGGGACTGGCAAGACAGAAACCACCAAA
GATTTGGCCAAAGCCTTGGCTAAGCAGTGTGTGGTCTTCAACTGCTCCGATGGTTTGGATTACAAAGCTATGGGGAAGTTCTTCAAGGGG
CTGGCACAGGCTGGAGCATGGGCGTGCTTTGATGAGTTCAACAGGATCGAGGTAGAAGTGCTGTCTGTGGTCGCTCAGCAGATCCTCAGC
ATCCAACAAGCCATCATTCGGAAGCTAAAGACATTCATCTTTGAAGGGACTGAGCTCTCTCTGAACCCAACCTGCGCTGTGTTCATCACC
ATGAACCCCGGGTATGCTGGCAGGGCTGAACTGCCCGACAATCTCAAGGCCTTGTTCCGGACAGTGGCCATGATGGTCCCAGATTACGCC
CTCATTGGAGAAATCTCCCTCTACTCCATGGGGTTTCTGGACTCCAGAAGTCTCGCCCAGAAGATCGTTGCGACCTACCGCCTGTGCTCG
GAACAACTGTCCTCTCAGCATCACTATGACTACGGTATGCGCGCTGTCAAGTCTGTGCTTACTGCCGCAGGAAACCTGAAGCTCAAGTAT
CCAGAGGAGAATGAAAGTGTCCTGCTGCTCCGGGCATTGCTTGATGTCAATCTGGCCAAGTTCTTAGCGCAAGATGTCCCTCTGTTTCAG
GGAATTATATCTGATTTATTTCCTGGAGTTGTTCTTCCAAAGCCAGACTATGAAGTTTTTCTGAAAGTGCTGAATGATAACATCAAAAAG
ATGAAACTCCAGCCAGTACCTTGGTTTATAGGGAAAATTATCCAGATCTACGAAATGATGCTGGTGAGACATGGCTATATGATTGTAGGA
GACCCCATGGGCGGCAAGACCTCTGCTTATAAAGTGTTGGCTGCAGCTCTCGGCGATTTACACGCAGCCAATCAGATGGAGGAGTTTGCT
GTGGAGTACAAGATCATCAACCCCAAGGCTATCACGATGGGGCAGCTGTATGGGTGCTTTGACCAAGTGAGCCACGAGTGGATGGATGGT
GTCCTTGCCAATGCTTTCCGGGAGCAAGCGTCTTCACTCTCTGATGATCGCAAGTGGATTATATTTGATGGGCCAGTGGATGCTATTTGG
ATTGAAAATATGAACACTGTTCTGGATGACAATAAAAAGCTGTGTCTCATGAGTGGGGAAATTATCCAGATGAACTCCAAGATGAGCCTG
ATCTTCGAGCCCGCCGACCTCGAGCAAGCCTCTCCAGCCACTGTGAGCAGGTGTGGGATGATCTACATGGAGCCCCATCAACTAGGCTGG
AAGCCCCTGAAGGATTCCTACATGGACACCCTGCCCTCCAGTCTCACCAAGGAGCACAAAGAATTGGTCAATGACATGTTCATGTGGCTT
GTCCAGCCCTGCCTGGAATTTGGTCGCCTTCATTGTAAATTTGTTGTCCAGACATCTCCCATCCACCTTGCCTTCTCAATGATGAGACTG
TACTCTTCTCTGCTTGATGAAATCAGGGCAGTAGAAGAGGAGGAAATGGAATTAGGTGAAGGCCTGTCAAGTCAACAGATCTTTCTCTGG
CTCCAAGGACTGTTTCTCTTTTCCTTGGTGTGGACCGTGGCTGGCACCATCAACGCAGACAGCAGAAAGAAATTTGATGTGTTTTTCCGC
AACCTGATCATGGGCATGGATGATAACCACCCAAGGCCCAAAAGCGTCAAACTCACCAAAAACAACATCTTTCCAGAAAGAGGTAGTGGG
CAGCAGTCAGTGACAGGTGTAACCTCTGTGGATGACAGCAACAGTTACTGGAGGATACGGGGGAAGAGTGCCACAGTGTGTGAGAGGGGA
ACCCCCATCAAGTGTGGCCAGCCCATCCGGCTGACACATGTCAACACTGGCCGAAACCTCCATAGTCACCACTTCACTTCACCTCTTTCT
GGAAACCAGGAAGTGAGTGCTTTTGGTGAGGAAGGTGAAGGTGATTATCTGGATGACTGGACAGTGCTCTGTAATGGACCCTACTGGGTG
AGAGATGGTGAGGTGCGGTTCAAACACTCTTCCACTGAGGTACTGCTGTCTGTCACAGGAGAACAATATGGTCGACCTATCAGTGGGCAA
AAAGAGGTGCATGGCATGGCCCAGCCAAGTCAGAACAACTACTGGAAAGCCATGGAAGGCATCTTCATGAAGCCCAGTGAGTTGTTGAAG
GCAGAAGCCCACCATGCAGAGCTGTGAATCTAGAGGCTCTGAGCCACTGTTAACGCACAATGTTCACAGACATCTGTTGCTGCCTCACCT
TGGGATCCCTGCCACAAGTTCCTTGGGCAGTGGCCATGTCACCATTGAGATGAAGATATACAACAGAAAATAGTGGCTGTGTTTGGAAGC
TTCAGCCCTGCACATTTGAACTAGTCACTCTCCCAGACTTGCGTGGGTCAGTTCTTTCTGAGTAGAGGACTTGCTGGTAAAGGGGCAGAT
GCTTTTTATTAGTACTGATAAAACAAACTGAGGGAAACATCCCTCTTAGCTGGGAAACTTTTACTCTTCAGGAGCTTGGCATCATGGACT
GTTAATGTATGTGATTTTCCCCCTATTTTCTCTCTCCAAAATGATAAAAACAATAATTTTATTATGAGTCACTGTGTTGTTATTTATTAG
GTGTGCTATTTCATTAGCTGCTTAATCCTTTGAGTCCTAAGACTCTTTGGAGACGCTATGAAGCTCCAATGTGGGCCCTTTTAAGAGCTT
TTCTTGCATACAAACCTTTTCTCCCTCTACTTTGACTTCTCTCCAGGCATCTCATCTTTAATAGATCTTTGACTAATTATAGCTAAAAAC

>23366_23366_1_DNAH3-SDF2_DNAH3_chr16_21030946_ENST00000261383_SDF2_chr17_26982501_ENST00000247020_length(amino acids)=2168AA_BP=2007
MGATGRLELTLAAPPHPGPAFQRSKARETQGEEEGSEMQIAKSDSIHHMSHSQGQPELPPLPASANEEPSGLYQTVMSHSFYPPLMQRTS
WTLAAPFKEQHHHRGPSDSIANNYSLMAQDLKLKDLLKVYQPATISVPRDRTGQGLPSSGNRSSSEPMRKKTKFSSRNKEDSTRIKLAFK
TSIFSPMKKEVKTSLTFPGSRPMSPEQQLDVMLQQEMEMESKEKKPSESDLERYYYYLTNGIRKDMIAPEEGEVMVRISKLISNTLLTSP
FLEPLMVVLVQEKENDYYCSLMKSIVDYILMDPMERKRLFIESIPRLFPQRVIRAPVPWHSVYRSAKKWNEEHLHTVNPMMLRLKELWFA
EFRDLRFVRTAEILAGKLPLQPQEFWDVIQKHCLEAHQTLLNKWIPTCAQLFTSRKEHWIHFAPKSNYDSSRNIEEYFASVASFMSLQLR
ELVIKSLEDLVSLFMIHKDGNDFKEPYQEMKFFIPQLIMIKLEVSEPIIVFNPSFDGCWELIRDSFLEIIKNSNGIPKLKYIPLKFSFTA
AAADRQCVKAAEPGEPSMHAAATAMAELKGYNLLLGTVNAEEKLVSDFLIQTFKVFQKNQVGPCKYLNVYKKYVDLLDNTAEQNIAAFLK
ENHDIDDFVTKINAIKKRRNEIASMNITVPLAMFCLDATALNHDLCERAQNLKDHLIQFQVDVNRDTNTSICNQYSHIADKVSEVPANTK
ELVSLIEFLKKSSAVTVFKLRRQLRDASERLEFLMDYADLPYQIEDIFDNSRNLLLHKRDQAEMDLIKRCSEFELRLEGYHRELESFRKR
EVMTTEEMKHNVEKLNELSKNLNRAFAEFELINKEEELLEKEKSTYPLLQAMLKNKVPYEQLWSTAYEFSIKSEEWMNGPLFLLNAEQIA
EEIGNMWRTTYKLIKTLSDVPAPRRLAENVKIKIDKFKQYIPILSISCNPGMKDRHWQQISEIVGYEIKPTETTCLSNMLEFGFGKFVEK
LEPIGAAASKEYSLEKNLDRMKLDWVNVTFSFVKYRDTDTNILCAIDDIQMLLDDHVIKTQTMCGSPFIKPIEAECRKWEEKLIRIQDNL
DAWLKCQATWLYLEPIFSSEDIIAQMPEEGRKFGIVDSYWKSLMSQAVKDNRILVAADQPRMAEKLQEANFLLEDIQKGLNDYLEKKRLF
FPRFFFLSNDELLEILSETKDPLRVQPHLKKCFEGIAKLEFTDNLEIVGMISSEKETVPFIQKIYPANAKGMVEKWLQQVEQMMLASMRE
VIGLGIEAYVKVPRNHWVLQWPGQVVICVSSIFWTQEVSQALAENTLLDFLKKSNDQIAQIVQLVRGKLSSGARLTLGALTVIDVHARDV
VAKLSEDRVSDLNDFQWISQLRYYWVAKDVQVQIITTEALYGYEYLGNSPRLVITPLTDRCYRTLMGALKLNLGGAPEGPAGTGKTETTK
DLAKALAKQCVVFNCSDGLDYKAMGKFFKGLAQAGAWACFDEFNRIEVEVLSVVAQQILSIQQAIIRKLKTFIFEGTELSLNPTCAVFIT
MNPGYAGRAELPDNLKALFRTVAMMVPDYALIGEISLYSMGFLDSRSLAQKIVATYRLCSEQLSSQHHYDYGMRAVKSVLTAAGNLKLKY
PEENESVLLLRALLDVNLAKFLAQDVPLFQGIISDLFPGVVLPKPDYEVFLKVLNDNIKKMKLQPVPWFIGKIIQIYEMMLVRHGYMIVG
DPMGGKTSAYKVLAAALGDLHAANQMEEFAVEYKIINPKAITMGQLYGCFDQVSHEWMDGVLANAFREQASSLSDDRKWIIFDGPVDAIW
IENMNTVLDDNKKLCLMSGEIIQMNSKMSLIFEPADLEQASPATVSRCGMIYMEPHQLGWKPLKDSYMDTLPSSLTKEHKELVNDMFMWL
VQPCLEFGRLHCKFVVQTSPIHLAFSMMRLYSSLLDEIRAVEEEEMELGEGLSSQQIFLWLQGLFLFSLVWTVAGTINADSRKKFDVFFR
NLIMGMDDNHPRPKSVKLTKNNIFPERGSGQQSVTGVTSVDDSNSYWRIRGKSATVCERGTPIKCGQPIRLTHVNTGRNLHSHHFTSPLS
GNQEVSAFGEEGEGDYLDDWTVLCNGPYWVRDGEVRFKHSSTEVLLSVTGEQYGRPISGQKEVHGMAQPSQNNYWKAMEGIFMKPSELLK

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Top

Fusion Gene PPI Analysis for DNAH3-SDF2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for DNAH3-SDF2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for DNAH3-SDF2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source