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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DNAJB1-EPS15L1 (FusionGDB2 ID:23419)

Fusion Gene Summary for DNAJB1-EPS15L1

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAJB1-EPS15L1
Fusion gene ID: 23419
HgeneTgene
Gene symbol

DNAJB1

EPS15L1

Gene ID

3337

58513

Gene nameDnaJ heat shock protein family (Hsp40) member B1epidermal growth factor receptor pathway substrate 15 like 1
SynonymsHSPF1|Hdj1|Hsp40|RSPH16B|Sis1EPS15R
Cytomap

19p13.12

19p13.11

Type of geneprotein-codingprotein-coding
DescriptiondnaJ homolog subfamily B member 1DnaJ (Hsp40) homolog, subfamily B, member 1dnaJ protein homolog 1heat shock 40 kDa protein 1human DnaJ protein 1radial spoke 16 homolog Bepidermal growth factor receptor substrate 15-like 1epidermal growth factor receptor substrate EPS15Reps15-related protein
Modification date2020031320200313
UniProtAcc

P25685

Q9UBC2

Ensembl transtripts involved in fusion geneENST00000254322, ENST00000396969, 
ENST00000248070, ENST00000535753, 
ENST00000594975, ENST00000597937, 
ENST00000602009, ENST00000455140, 
Fusion gene scores* DoF score5 X 8 X 5=20012 X 10 X 6=720
# samples 1013
** MAII scorelog2(10/200*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNAJB1 [Title/Abstract] AND EPS15L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNAJB1(14628951)-EPS15L1(16472795), # samples:2
DNAJB1(14628950)-EPS15L1(16472795), # samples:2
Anticipated loss of major functional domain due to fusion event.DNAJB1-EPS15L1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
DNAJB1-EPS15L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DNAJB1-EPS15L1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
DNAJB1-EPS15L1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNAJB1

GO:0032781

positive regulation of ATPase activity

23921388

HgeneDNAJB1

GO:0051085

chaperone cofactor-dependent protein refolding

18620420

HgeneDNAJB1

GO:0090084

negative regulation of inclusion body assembly

21231916

HgeneDNAJB1

GO:0097201

negative regulation of transcription from RNA polymerase II promoter in response to stress

9499401


check buttonFusion gene breakpoints across DNAJB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EPS15L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-04-1519-01ADNAJB1chr19

14628951

-EPS15L1chr19

16466662

-
ChimerDB4OVTCGA-04-1519-01ADNAJB1chr19

14628951

-EPS15L1chr19

16472795

-
ChimerDB4OVTCGA-04-1519DNAJB1chr19

14628950

-EPS15L1chr19

16472795

-


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Fusion Gene ORF analysis for DNAJB1-EPS15L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000254322ENST00000248070DNAJB1chr19

14628951

-EPS15L1chr19

16466662

-
5CDS-intronENST00000254322ENST00000535753DNAJB1chr19

14628951

-EPS15L1chr19

16466662

-
5CDS-intronENST00000254322ENST00000594975DNAJB1chr19

14628951

-EPS15L1chr19

16466662

-
5CDS-intronENST00000254322ENST00000597937DNAJB1chr19

14628951

-EPS15L1chr19

16466662

-
5CDS-intronENST00000254322ENST00000597937DNAJB1chr19

14628951

-EPS15L1chr19

16472795

-
5CDS-intronENST00000254322ENST00000597937DNAJB1chr19

14628950

-EPS15L1chr19

16472795

-
5CDS-intronENST00000254322ENST00000602009DNAJB1chr19

14628951

-EPS15L1chr19

16466662

-
5CDS-intronENST00000254322ENST00000602009DNAJB1chr19

14628951

-EPS15L1chr19

16472795

-
5CDS-intronENST00000254322ENST00000602009DNAJB1chr19

14628950

-EPS15L1chr19

16472795

-
Frame-shiftENST00000254322ENST00000455140DNAJB1chr19

14628951

-EPS15L1chr19

16466662

-
Frame-shiftENST00000254322ENST00000455140DNAJB1chr19

14628951

-EPS15L1chr19

16472795

-
Frame-shiftENST00000254322ENST00000455140DNAJB1chr19

14628950

-EPS15L1chr19

16472795

-
Frame-shiftENST00000254322ENST00000594975DNAJB1chr19

14628951

-EPS15L1chr19

16472795

-
Frame-shiftENST00000254322ENST00000594975DNAJB1chr19

14628950

-EPS15L1chr19

16472795

-
In-frameENST00000254322ENST00000248070DNAJB1chr19

14628951

-EPS15L1chr19

16472795

-
In-frameENST00000254322ENST00000248070DNAJB1chr19

14628950

-EPS15L1chr19

16472795

-
In-frameENST00000254322ENST00000535753DNAJB1chr19

14628951

-EPS15L1chr19

16472795

-
In-frameENST00000254322ENST00000535753DNAJB1chr19

14628950

-EPS15L1chr19

16472795

-
intron-3CDSENST00000396969ENST00000248070DNAJB1chr19

14628951

-EPS15L1chr19

16472795

-
intron-3CDSENST00000396969ENST00000248070DNAJB1chr19

14628950

-EPS15L1chr19

16472795

-
intron-3CDSENST00000396969ENST00000455140DNAJB1chr19

14628951

-EPS15L1chr19

16466662

-
intron-3CDSENST00000396969ENST00000455140DNAJB1chr19

14628951

-EPS15L1chr19

16472795

-
intron-3CDSENST00000396969ENST00000455140DNAJB1chr19

14628950

-EPS15L1chr19

16472795

-
intron-3CDSENST00000396969ENST00000535753DNAJB1chr19

14628951

-EPS15L1chr19

16472795

-
intron-3CDSENST00000396969ENST00000535753DNAJB1chr19

14628950

-EPS15L1chr19

16472795

-
intron-3CDSENST00000396969ENST00000594975DNAJB1chr19

14628951

-EPS15L1chr19

16472795

-
intron-3CDSENST00000396969ENST00000594975DNAJB1chr19

14628950

-EPS15L1chr19

16472795

-
intron-intronENST00000396969ENST00000248070DNAJB1chr19

14628951

-EPS15L1chr19

16466662

-
intron-intronENST00000396969ENST00000535753DNAJB1chr19

14628951

-EPS15L1chr19

16466662

-
intron-intronENST00000396969ENST00000594975DNAJB1chr19

14628951

-EPS15L1chr19

16466662

-
intron-intronENST00000396969ENST00000597937DNAJB1chr19

14628951

-EPS15L1chr19

16466662

-
intron-intronENST00000396969ENST00000597937DNAJB1chr19

14628951

-EPS15L1chr19

16472795

-
intron-intronENST00000396969ENST00000597937DNAJB1chr19

14628950

-EPS15L1chr19

16472795

-
intron-intronENST00000396969ENST00000602009DNAJB1chr19

14628951

-EPS15L1chr19

16466662

-
intron-intronENST00000396969ENST00000602009DNAJB1chr19

14628951

-EPS15L1chr19

16472795

-
intron-intronENST00000396969ENST00000602009DNAJB1chr19

14628950

-EPS15L1chr19

16472795

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000254322DNAJB1chr1914628951-ENST00000248070EPS15L1chr1916472795-6862825802193
ENST00000254322DNAJB1chr1914628951-ENST00000535753EPS15L1chr1916472795-67028211496161
ENST00000254322DNAJB1chr1914628950-ENST00000248070EPS15L1chr1916472795-6862825802193
ENST00000254322DNAJB1chr1914628950-ENST00000535753EPS15L1chr1916472795-67028211496161

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000254322ENST00000248070DNAJB1chr1914628951-EPS15L1chr1916472795-0.0103753220.9896247
ENST00000254322ENST00000535753DNAJB1chr1914628951-EPS15L1chr1916472795-0.0106167290.9893833
ENST00000254322ENST00000248070DNAJB1chr1914628950-EPS15L1chr1916472795-0.0103753220.9896247
ENST00000254322ENST00000535753DNAJB1chr1914628950-EPS15L1chr1916472795-0.0106167290.9893833

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Fusion Genomic Features for DNAJB1-EPS15L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DNAJB1-EPS15L1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:14628951/chr19:16472795)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAJB1

P25685

EPS15L1

Q9UBC2

FUNCTION: Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:9499401}.FUNCTION: Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNAJB1chr19:14628950chr19:16472795ENST00000254322-132_7070341.0DomainJ
HgeneDNAJB1chr19:14628951chr19:16472795ENST00000254322-132_7070341.0DomainJ
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016172_1840602.0Calcium bindingOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016172_1840602.0Calcium bindingOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016386_5530602.0Coiled coilOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016386_5530602.0Coiled coilOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022750_816749755.0Compositional biasNote=Pro-rich
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016750_8160602.0Compositional biasNote=Pro-rich
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022750_816749755.0Compositional biasNote=Pro-rich
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016750_8160602.0Compositional biasNote=Pro-rich
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016127_2150602.0DomainEH 2
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016159_1940602.0DomainEF-hand
TgeneEPS15L1chr19:14628950chr19:16472795ENST0000059793701615_1040602.0DomainEH 1
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016275_3650602.0DomainEH 3
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016127_2150602.0DomainEH 2
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016159_1940602.0DomainEF-hand
TgeneEPS15L1chr19:14628951chr19:16472795ENST0000059793701615_1040602.0DomainEH 1
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016275_3650602.0DomainEH 3
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016618_8350602.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016618_8350602.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123806_808793865.0RepeatNote=13
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123812_814793865.0RepeatNote=14
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123833_835793865.0RepeatNote=15
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124806_808793911.0RepeatNote=13
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124812_814793911.0RepeatNote=14
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124833_835793911.0RepeatNote=15
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022754_756749755.0RepeatNote=12
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022806_808749755.0RepeatNote=13
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022812_814749755.0RepeatNote=14
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022833_835749755.0RepeatNote=15
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016618_6200602.0RepeatNote=1
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016640_6420602.0RepeatNote=2
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016645_6470602.0RepeatNote=3
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016650_6520602.0RepeatNote=4
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016656_6580602.0RepeatNote=5
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016661_6630602.0RepeatNote=6
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016667_6690602.0RepeatNote=7
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016685_6870602.0RepeatNote=8
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016690_6920602.0RepeatNote=9
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016709_7110602.0RepeatNote=10
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016728_7300602.0RepeatNote=11
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016754_7560602.0RepeatNote=12
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016806_8080602.0RepeatNote=13
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016812_8140602.0RepeatNote=14
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000597937016833_8350602.0RepeatNote=15
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123806_808793865.0RepeatNote=13
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123812_814793865.0RepeatNote=14
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123833_835793865.0RepeatNote=15
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124806_808793911.0RepeatNote=13
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124812_814793911.0RepeatNote=14
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124833_835793911.0RepeatNote=15
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022754_756749755.0RepeatNote=12
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022806_808749755.0RepeatNote=13
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022812_814749755.0RepeatNote=14
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022833_835749755.0RepeatNote=15
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016618_6200602.0RepeatNote=1
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016640_6420602.0RepeatNote=2
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016645_6470602.0RepeatNote=3
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016650_6520602.0RepeatNote=4
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016656_6580602.0RepeatNote=5
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016661_6630602.0RepeatNote=6
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016667_6690602.0RepeatNote=7
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016685_6870602.0RepeatNote=8
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016690_6920602.0RepeatNote=9
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016709_7110602.0RepeatNote=10
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016728_7300602.0RepeatNote=11
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016754_7560602.0RepeatNote=12
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016806_8080602.0RepeatNote=13
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016812_8140602.0RepeatNote=14
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000597937016833_8350602.0RepeatNote=15

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123172_184793865.0Calcium bindingOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124172_184793911.0Calcium bindingOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022172_184749755.0Calcium bindingOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123172_184793865.0Calcium bindingOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124172_184793911.0Calcium bindingOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022172_184749755.0Calcium bindingOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123386_553793865.0Coiled coilOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124386_553793911.0Coiled coilOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022386_553749755.0Coiled coilOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123386_553793865.0Coiled coilOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124386_553793911.0Coiled coilOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022386_553749755.0Coiled coilOntology_term=ECO:0000255
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123750_816793865.0Compositional biasNote=Pro-rich
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124750_816793911.0Compositional biasNote=Pro-rich
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123750_816793865.0Compositional biasNote=Pro-rich
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124750_816793911.0Compositional biasNote=Pro-rich
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123127_215793865.0DomainEH 2
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123159_194793865.0DomainEF-hand
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000248070212315_104793865.0DomainEH 1
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123275_365793865.0DomainEH 3
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124127_215793911.0DomainEH 2
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124159_194793911.0DomainEF-hand
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000455140212415_104793911.0DomainEH 1
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124275_365793911.0DomainEH 3
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022127_215749755.0DomainEH 2
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022159_194749755.0DomainEF-hand
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000535753202215_104749755.0DomainEH 1
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022275_365749755.0DomainEH 3
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123127_215793865.0DomainEH 2
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123159_194793865.0DomainEF-hand
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000248070212315_104793865.0DomainEH 1
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123275_365793865.0DomainEH 3
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124127_215793911.0DomainEH 2
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124159_194793911.0DomainEF-hand
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000455140212415_104793911.0DomainEH 1
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124275_365793911.0DomainEH 3
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022127_215749755.0DomainEH 2
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022159_194749755.0DomainEF-hand
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000535753202215_104749755.0DomainEH 1
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022275_365749755.0DomainEH 3
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123618_835793865.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124618_835793911.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022618_835749755.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123618_835793865.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124618_835793911.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022618_835749755.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123618_620793865.0RepeatNote=1
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123640_642793865.0RepeatNote=2
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123645_647793865.0RepeatNote=3
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123650_652793865.0RepeatNote=4
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123656_658793865.0RepeatNote=5
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123661_663793865.0RepeatNote=6
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123667_669793865.0RepeatNote=7
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123685_687793865.0RepeatNote=8
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123690_692793865.0RepeatNote=9
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123709_711793865.0RepeatNote=10
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123728_730793865.0RepeatNote=11
TgeneEPS15L1chr19:14628950chr19:16472795ENST000002480702123754_756793865.0RepeatNote=12
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124618_620793911.0RepeatNote=1
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124640_642793911.0RepeatNote=2
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124645_647793911.0RepeatNote=3
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124650_652793911.0RepeatNote=4
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124656_658793911.0RepeatNote=5
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124661_663793911.0RepeatNote=6
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124667_669793911.0RepeatNote=7
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124685_687793911.0RepeatNote=8
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124690_692793911.0RepeatNote=9
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124709_711793911.0RepeatNote=10
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124728_730793911.0RepeatNote=11
TgeneEPS15L1chr19:14628950chr19:16472795ENST000004551402124754_756793911.0RepeatNote=12
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022618_620749755.0RepeatNote=1
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022640_642749755.0RepeatNote=2
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022645_647749755.0RepeatNote=3
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022650_652749755.0RepeatNote=4
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022656_658749755.0RepeatNote=5
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022661_663749755.0RepeatNote=6
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022667_669749755.0RepeatNote=7
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022685_687749755.0RepeatNote=8
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022690_692749755.0RepeatNote=9
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022709_711749755.0RepeatNote=10
TgeneEPS15L1chr19:14628950chr19:16472795ENST000005357532022728_730749755.0RepeatNote=11
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123618_620793865.0RepeatNote=1
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123640_642793865.0RepeatNote=2
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123645_647793865.0RepeatNote=3
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123650_652793865.0RepeatNote=4
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123656_658793865.0RepeatNote=5
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123661_663793865.0RepeatNote=6
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123667_669793865.0RepeatNote=7
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123685_687793865.0RepeatNote=8
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123690_692793865.0RepeatNote=9
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123709_711793865.0RepeatNote=10
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123728_730793865.0RepeatNote=11
TgeneEPS15L1chr19:14628951chr19:16472795ENST000002480702123754_756793865.0RepeatNote=12
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124618_620793911.0RepeatNote=1
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124640_642793911.0RepeatNote=2
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124645_647793911.0RepeatNote=3
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124650_652793911.0RepeatNote=4
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124656_658793911.0RepeatNote=5
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124661_663793911.0RepeatNote=6
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124667_669793911.0RepeatNote=7
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124685_687793911.0RepeatNote=8
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124690_692793911.0RepeatNote=9
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124709_711793911.0RepeatNote=10
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124728_730793911.0RepeatNote=11
TgeneEPS15L1chr19:14628951chr19:16472795ENST000004551402124754_756793911.0RepeatNote=12
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022618_620749755.0RepeatNote=1
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022640_642749755.0RepeatNote=2
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022645_647749755.0RepeatNote=3
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022650_652749755.0RepeatNote=4
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022656_658749755.0RepeatNote=5
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022661_663749755.0RepeatNote=6
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022667_669749755.0RepeatNote=7
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022685_687749755.0RepeatNote=8
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022690_692749755.0RepeatNote=9
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022709_711749755.0RepeatNote=10
TgeneEPS15L1chr19:14628951chr19:16472795ENST000005357532022728_730749755.0RepeatNote=11


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Fusion Gene Sequence for DNAJB1-EPS15L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>23419_23419_1_DNAJB1-EPS15L1_DNAJB1_chr19_14628950_ENST00000254322_EPS15L1_chr19_16472795_ENST00000248070_length(transcript)=686nt_BP=282nt
AGAGTCCGGGACTGGTCGGCGGCGGAGCCGGGGGACGGCGACAGCGGGTCGGCGGGCCGCAGGAGGGGGTCATGGGTAAAGACTACTACC
AGACGTTGGGCCTGGCCCGCGGCGCGTCGGACGAGGAGATCAAGCGGGCCTACCGCCGCCAGGCGCTGCGCTACCACCCGGACAAGAACA
AGGAGCCCGGCGCCGAGGAGAAGTTCAAGGAGATCGCTGAGGCCTACGACGTGCTCAGCGACCCGCGCAAGCGCGAGATCTTCGACCGCT
ACGGGGAGGAAGGTAAAAGTACACCTGTAAGCCAGCTTGGTTCCGCAGACTTTCCCGAGGCCCCCGATCCATTCCAGCCACTCGGGGCTG
ACAGCGGCGACCCGTTCCAAAGTAAAAAGGGGTTTGGGGACCCGTTTAGTGGAAAAGACCCATTTGTCCCCTCCTCTGCAGCTAAACCTT
CTAAGGCCTCTGCCTCGGGCTTTGCAGACTTCACCTCTGTAAGTTGAGTCCTCCGCCTCCGGGCCACCCCACTCCCTTCCGCTTGCAGCT
TCCCTGGGATTTTTGTCTCCTTTTAAAGGCAAACCTCCCAGCTTCTTTAGCCTCTTGGTACCTCACACTCTCTGTCCCTCGCGTTATTTA

>23419_23419_1_DNAJB1-EPS15L1_DNAJB1_chr19_14628950_ENST00000254322_EPS15L1_chr19_16472795_ENST00000248070_length(amino acids)=193AA_BP=1
MGGLPLKGDKNPREAASGREWGGPEAEDSTYRGEVCKARGRGLRRFSCRGGDKWVFSTKRVPKPLFTLERVAAVSPEWLEWIGGLGKVCG
TKLAYRCTFTFLPVAVEDLALARVAEHVVGLSDLLELLLGAGLLVLVRVVAQRLAAVGPLDLLVRRAAGQAQRLVVVFTHDPLLRPADPL

--------------------------------------------------------------
>23419_23419_2_DNAJB1-EPS15L1_DNAJB1_chr19_14628950_ENST00000254322_EPS15L1_chr19_16472795_ENST00000535753_length(transcript)=670nt_BP=282nt
AGAGTCCGGGACTGGTCGGCGGCGGAGCCGGGGGACGGCGACAGCGGGTCGGCGGGCCGCAGGAGGGGGTCATGGGTAAAGACTACTACC
AGACGTTGGGCCTGGCCCGCGGCGCGTCGGACGAGGAGATCAAGCGGGCCTACCGCCGCCAGGCGCTGCGCTACCACCCGGACAAGAACA
AGGAGCCCGGCGCCGAGGAGAAGTTCAAGGAGATCGCTGAGGCCTACGACGTGCTCAGCGACCCGCGCAAGCGCGAGATCTTCGACCGCT
ACGGGGAGGAAGGTAAAAGTACACCTGTAAGCCAGCTTGGTTCCGCAGACTTTCCCGAGGCCCCCGATCCATTCCAGCCACTCGGGGCTG
ACAGCGGCGACCCGTTCCAAAGTAAAAAGGGGTTTGGGGACCCGTTTAGTGGAAAAGACCCATTTGTCCCCTCCTCTGCAGCTAAACCTT
CTAAGGCCTCTGCCTCGGGCTTTGCAGACTTCACCTCTGTAAGTTGAGTCCTCCGCCTCCGGGCCACCCCACTCCCTTCCGCTTGCAGCT
TCCCTGGGATTTTTGTCTCCTTTTAAAGGCAAACCTCCCAGCTTCTTTAGCCTCTTGGTACCTCACACTCTCTGTCCCTCGCGTTATTTA

>23419_23419_2_DNAJB1-EPS15L1_DNAJB1_chr19_14628950_ENST00000254322_EPS15L1_chr19_16472795_ENST00000535753_length(amino acids)=161AA_BP=90
MVGGGAGGRRQRVGGPQEGVMGKDYYQTLGLARGASDEEIKRAYRRQALRYHPDKNKEPGAEEKFKEIAEAYDVLSDPRKREIFDRYGEE

--------------------------------------------------------------
>23419_23419_3_DNAJB1-EPS15L1_DNAJB1_chr19_14628951_ENST00000254322_EPS15L1_chr19_16472795_ENST00000248070_length(transcript)=686nt_BP=282nt
AGAGTCCGGGACTGGTCGGCGGCGGAGCCGGGGGACGGCGACAGCGGGTCGGCGGGCCGCAGGAGGGGGTCATGGGTAAAGACTACTACC
AGACGTTGGGCCTGGCCCGCGGCGCGTCGGACGAGGAGATCAAGCGGGCCTACCGCCGCCAGGCGCTGCGCTACCACCCGGACAAGAACA
AGGAGCCCGGCGCCGAGGAGAAGTTCAAGGAGATCGCTGAGGCCTACGACGTGCTCAGCGACCCGCGCAAGCGCGAGATCTTCGACCGCT
ACGGGGAGGAAGGTAAAAGTACACCTGTAAGCCAGCTTGGTTCCGCAGACTTTCCCGAGGCCCCCGATCCATTCCAGCCACTCGGGGCTG
ACAGCGGCGACCCGTTCCAAAGTAAAAAGGGGTTTGGGGACCCGTTTAGTGGAAAAGACCCATTTGTCCCCTCCTCTGCAGCTAAACCTT
CTAAGGCCTCTGCCTCGGGCTTTGCAGACTTCACCTCTGTAAGTTGAGTCCTCCGCCTCCGGGCCACCCCACTCCCTTCCGCTTGCAGCT
TCCCTGGGATTTTTGTCTCCTTTTAAAGGCAAACCTCCCAGCTTCTTTAGCCTCTTGGTACCTCACACTCTCTGTCCCTCGCGTTATTTA

>23419_23419_3_DNAJB1-EPS15L1_DNAJB1_chr19_14628951_ENST00000254322_EPS15L1_chr19_16472795_ENST00000248070_length(amino acids)=193AA_BP=1
MGGLPLKGDKNPREAASGREWGGPEAEDSTYRGEVCKARGRGLRRFSCRGGDKWVFSTKRVPKPLFTLERVAAVSPEWLEWIGGLGKVCG
TKLAYRCTFTFLPVAVEDLALARVAEHVVGLSDLLELLLGAGLLVLVRVVAQRLAAVGPLDLLVRRAAGQAQRLVVVFTHDPLLRPADPL

--------------------------------------------------------------
>23419_23419_4_DNAJB1-EPS15L1_DNAJB1_chr19_14628951_ENST00000254322_EPS15L1_chr19_16472795_ENST00000535753_length(transcript)=670nt_BP=282nt
AGAGTCCGGGACTGGTCGGCGGCGGAGCCGGGGGACGGCGACAGCGGGTCGGCGGGCCGCAGGAGGGGGTCATGGGTAAAGACTACTACC
AGACGTTGGGCCTGGCCCGCGGCGCGTCGGACGAGGAGATCAAGCGGGCCTACCGCCGCCAGGCGCTGCGCTACCACCCGGACAAGAACA
AGGAGCCCGGCGCCGAGGAGAAGTTCAAGGAGATCGCTGAGGCCTACGACGTGCTCAGCGACCCGCGCAAGCGCGAGATCTTCGACCGCT
ACGGGGAGGAAGGTAAAAGTACACCTGTAAGCCAGCTTGGTTCCGCAGACTTTCCCGAGGCCCCCGATCCATTCCAGCCACTCGGGGCTG
ACAGCGGCGACCCGTTCCAAAGTAAAAAGGGGTTTGGGGACCCGTTTAGTGGAAAAGACCCATTTGTCCCCTCCTCTGCAGCTAAACCTT
CTAAGGCCTCTGCCTCGGGCTTTGCAGACTTCACCTCTGTAAGTTGAGTCCTCCGCCTCCGGGCCACCCCACTCCCTTCCGCTTGCAGCT
TCCCTGGGATTTTTGTCTCCTTTTAAAGGCAAACCTCCCAGCTTCTTTAGCCTCTTGGTACCTCACACTCTCTGTCCCTCGCGTTATTTA

>23419_23419_4_DNAJB1-EPS15L1_DNAJB1_chr19_14628951_ENST00000254322_EPS15L1_chr19_16472795_ENST00000535753_length(amino acids)=161AA_BP=90
MVGGGAGGRRQRVGGPQEGVMGKDYYQTLGLARGASDEEIKRAYRRQALRYHPDKNKEPGAEEKFKEIAEAYDVLSDPRKREIFDRYGEE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DNAJB1-EPS15L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneEPS15L1chr19:14628950chr19:16472795ENST0000059793701615_3680602.0DAB2
TgeneEPS15L1chr19:14628951chr19:16472795ENST0000059793701615_3680602.0DAB2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000248070212315_368793.3333333333334865.0DAB2
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000455140212415_368793.3333333333334911.0DAB2
TgeneEPS15L1chr19:14628950chr19:16472795ENST00000535753202215_368749.0755.0DAB2
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000248070212315_368793.3333333333334865.0DAB2
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000455140212415_368793.3333333333334911.0DAB2
TgeneEPS15L1chr19:14628951chr19:16472795ENST00000535753202215_368749.0755.0DAB2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DNAJB1-EPS15L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DNAJB1-EPS15L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource