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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:DNAJB1-MED26 (FusionGDB2 ID:23420) |
Fusion Gene Summary for DNAJB1-MED26 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DNAJB1-MED26 | Fusion gene ID: 23420 | Hgene | Tgene | Gene symbol | DNAJB1 | MED26 | Gene ID | 3337 | 9441 |
| Gene name | DnaJ heat shock protein family (Hsp40) member B1 | mediator complex subunit 26 | |
| Synonyms | HSPF1|Hdj1|Hsp40|RSPH16B|Sis1 | CRSP7|CRSP70 | |
| Cytomap | 19p13.12 | 19p13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dnaJ homolog subfamily B member 1DnaJ (Hsp40) homolog, subfamily B, member 1dnaJ protein homolog 1heat shock 40 kDa protein 1human DnaJ protein 1radial spoke 16 homolog B | mediator of RNA polymerase II transcription subunit 26ARC70CRSP complex subunit 7activator-recruited cofactor 70 kDa componentcofactor required for Sp1 transcriptional activation subunit 7cofactor required for Sp1 transcriptional activation, subunit | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P25685 | O95402 | |
| Ensembl transtripts involved in fusion gene | ENST00000254322, ENST00000396969, | ENST00000263390, | |
| Fusion gene scores | * DoF score | 5 X 8 X 5=200 | 5 X 3 X 3=45 |
| # samples | 10 | 9 | |
| ** MAII score | log2(10/200*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/45*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DNAJB1 [Title/Abstract] AND MED26 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DNAJB1(14627278)-MED26(16689220), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DNAJB1 | GO:0032781 | positive regulation of ATPase activity | 23921388 |
| Hgene | DNAJB1 | GO:0051085 | chaperone cofactor-dependent protein refolding | 18620420 |
| Hgene | DNAJB1 | GO:0090084 | negative regulation of inclusion body assembly | 21231916 |
| Hgene | DNAJB1 | GO:0097201 | negative regulation of transcription from RNA polymerase II promoter in response to stress | 9499401 |
| Tgene | MED26 | GO:0006357 | regulation of transcription by RNA polymerase II | 15989967 |
| Fusion gene breakpoints across DNAJB1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across MED26 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | OV | TCGA-25-1319-01A | DNAJB1 | chr19 | 14627278 | - | MED26 | chr19 | 16689220 | - |
| ChimerDB4 | OV | TCGA-25-1319 | DNAJB1 | chr19 | 14627277 | - | MED26 | chr19 | 16689220 | - |
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Fusion Gene ORF analysis for DNAJB1-MED26 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000254322 | ENST00000263390 | DNAJB1 | chr19 | 14627278 | - | MED26 | chr19 | 16689220 | - |
| In-frame | ENST00000254322 | ENST00000263390 | DNAJB1 | chr19 | 14627277 | - | MED26 | chr19 | 16689220 | - |
| In-frame | ENST00000396969 | ENST00000263390 | DNAJB1 | chr19 | 14627278 | - | MED26 | chr19 | 16689220 | - |
| In-frame | ENST00000396969 | ENST00000263390 | DNAJB1 | chr19 | 14627277 | - | MED26 | chr19 | 16689220 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000254322 | DNAJB1 | chr19 | 14627278 | - | ENST00000263390 | MED26 | chr19 | 16689220 | - | 3702 | 863 | 11 | 2593 | 860 |
| ENST00000396969 | DNAJB1 | chr19 | 14627278 | - | ENST00000263390 | MED26 | chr19 | 16689220 | - | 3604 | 765 | 273 | 2495 | 740 |
| ENST00000254322 | DNAJB1 | chr19 | 14627277 | - | ENST00000263390 | MED26 | chr19 | 16689220 | - | 3702 | 863 | 11 | 2593 | 860 |
| ENST00000396969 | DNAJB1 | chr19 | 14627277 | - | ENST00000263390 | MED26 | chr19 | 16689220 | - | 3604 | 765 | 273 | 2495 | 740 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000254322 | ENST00000263390 | DNAJB1 | chr19 | 14627278 | - | MED26 | chr19 | 16689220 | - | 0.002772406 | 0.9972276 |
| ENST00000396969 | ENST00000263390 | DNAJB1 | chr19 | 14627278 | - | MED26 | chr19 | 16689220 | - | 0.006127701 | 0.9938723 |
| ENST00000254322 | ENST00000263390 | DNAJB1 | chr19 | 14627277 | - | MED26 | chr19 | 16689220 | - | 0.002772406 | 0.9972276 |
| ENST00000396969 | ENST00000263390 | DNAJB1 | chr19 | 14627277 | - | MED26 | chr19 | 16689220 | - | 0.006127701 | 0.9938723 |
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Fusion Genomic Features for DNAJB1-MED26 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for DNAJB1-MED26 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:14627278/chr19:16689220) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DNAJB1 | MED26 |
| FUNCTION: Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:9499401}. | FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DNAJB1 | chr19:14627277 | chr19:16689220 | ENST00000254322 | - | 2 | 3 | 2_70 | 264 | 341.0 | Domain | J |
| Hgene | DNAJB1 | chr19:14627278 | chr19:16689220 | ENST00000254322 | - | 2 | 3 | 2_70 | 264 | 341.0 | Domain | J |
| Tgene | MED26 | chr19:14627277 | chr19:16689220 | ENST00000263390 | 0 | 3 | 228_325 | 24 | 601.0 | Compositional bias | Note=Pro-rich | |
| Tgene | MED26 | chr19:14627278 | chr19:16689220 | ENST00000263390 | 0 | 3 | 228_325 | 24 | 601.0 | Compositional bias | Note=Pro-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | MED26 | chr19:14627277 | chr19:16689220 | ENST00000263390 | 0 | 3 | 10_87 | 24 | 601.0 | Domain | TFIIS N-terminal | |
| Tgene | MED26 | chr19:14627278 | chr19:16689220 | ENST00000263390 | 0 | 3 | 10_87 | 24 | 601.0 | Domain | TFIIS N-terminal |
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Fusion Gene Sequence for DNAJB1-MED26 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >23420_23420_1_DNAJB1-MED26_DNAJB1_chr19_14627277_ENST00000254322_MED26_chr19_16689220_ENST00000263390_length(transcript)=3702nt_BP=863nt AGAGTCCGGGACTGGTCGGCGGCGGAGCCGGGGGACGGCGACAGCGGGTCGGCGGGCCGCAGGAGGGGGTCATGGGTAAAGACTACTACC AGACGTTGGGCCTGGCCCGCGGCGCGTCGGACGAGGAGATCAAGCGGGCCTACCGCCGCCAGGCGCTGCGCTACCACCCGGACAAGAACA AGGAGCCCGGCGCCGAGGAGAAGTTCAAGGAGATCGCTGAGGCCTACGACGTGCTCAGCGACCCGCGCAAGCGCGAGATCTTCGACCGCT ACGGGGAGGAAGGCCTAAAGGGGAGTGGCCCCAGTGGCGGTAGCGGCGGTGGTGCCAATGGTACCTCTTTCAGCTACACATTCCATGGAG ACCCTCATGCCATGTTTGCTGAGTTCTTCGGTGGCAGAAATCCCTTTGACACCTTTTTTGGGCAGCGGAACGGGGAGGAAGGCATGGACA TTGATGACCCATTCTCTGGCTTCCCTATGGGCATGGGTGGCTTCACCAACGTGAACTTTGGCCGCTCCCGCTCTGCCCAAGAGCCCGCCC GAAAGAAGCAAGATCCCCCAGTCACCCACGACCTTCGAGTCTCCCTTGAAGAGATCTACAGCGGCTGTACCAAGAAGATGAAAATCTCCC ACAAGCGGCTAAACCCCGACGGAAAGAGCATTCGAAACGAAGACAAAATATTGACCATCGAAGTGAAGAAGGGGTGGAAAGAAGGAACCA AAATCACTTTCCCCAAGGAAGGAGACCAGACCTCCAACAACATTCCAGCTGATATCGTCTTTGTTTTAAAGGACAAGCCCCACAATATCT TTAAGAGAGATGGCTCTGATGTCATTTATCCTGCCAGGATCAGCCTCCGGGAGATCCGGAACATGGTGGCGGTGCTGGAAGTCATCTCCA GCCTGGAGAAATACCCTATTACCAAAGAGGCACTTGAGGAAACACGACTTGGGAAGCTCATCAACGACGTCCGCAAGAAAACCAAGAACG AGGAGCTCGCCAAGCGGGCCAAGAAGCTGCTGCGGAGCTGGCAGAAGCTCATCGAGCCGGCACACCAGCATGAGGCGGCGCTGCGGGGGC TGGCGGGGGCCACCGGCTCTGCCAACGGGGGCGCACACAACTGCCGGCCGGAGGTGGGGGCGGCTGGCCCACCCAGGAGCATCCATGACC TGAAGAGCCGCAATGACCTCCAGAGGCTGCCCGGGCAGCGGCTGGACAGGCTGGGCAGCCGCAAGCGCCGGGGTGACCAGCGTGACCTCG GCCACCCAGGGCCGCCACCCAAGGTCTCCAAAGCTAGCCACGACCCCCTGGTCCCCAACTCATCCCCCCTCCCCACCAACGGGATCAGTG GGAGTCCAGAGAGCTTCGCCAGCTCCCTGGATGGCAGTGGGCATGCAGGCCCAGAGGGCAGCCGCCTGGAGCGTGACGAGAATGACAAGC ACAGTGGCAAGATCCCCGTCAACGCCGTGCGACCGCACACCAGCTCCCCGGGCCTGGGCAAGCCCCCTGGACCCTGCTTGCAGCCAAAGG CTTCGGTGCTGCAGCAGCTGGACAGGGTGGACGAGACTCCGGGGCCTCCCCATCCCAAGGGACCCCCTCGCTGCTCTTTCAGTCCTCGGA ACTCACGGCATGAGGGCTCCTTTGCCCGGCAGCAGAGCTTGTATGCACCCAAGGGCTCCGTGCCCAGCCCCTCACCGCGGCCCCAGGCAC TCGATGCCACACAGGTGCCGTCACCGCTTCCACTGGCACAGCCGTCCACACCCCCCGTACGGCGGCTCGAGCTGCTGCCCAGTGCGGAAA GCCCAGTGTGCTGGCTTGAGCAGCCTGAGAGCCACCAGCGGCTGGCGGGGCCGGGCTGCAAGGCAGGGCTGTCCCCAGCCGAGCCCCTCC TGTCCCGGGCAGGCTTTTCCCCAGACTCCTCCAAGGCGGACAGTGATGCTGCCTCCTCAGGGGGCTCGGACAGTAAAAAGAAGAAGAGGT ACCGACCTCGAGACTATACGGTTAACTTGGACGGGCAGGTGGCTGAGGCGGGCGTCAAGCCTGTCCGGTTAAAAGAGCGGAAGCTCACCT TTGACCCCATGACGAGACAGATCAAACCTCTGACCCAGAAAGAGCCAGTGCGGGCAGACAGCCCTGTGCACATGGAGCAGCAGTCCAGGA CAGAGCTGGACAAGCAGGAGGCCAAGGCCAGCCTCCAGAGCCCCTTCGAACAGACGAACTGGAAGGAGCTGTCACGCAACGAGATCATCC AGTCCTACCTGAGCCGGCAGAGCAGCCTGCTCTCATCATCGGGCGCGCAGACCCCAGGGGCTCACCACTTCATGTCTGAGTACCTGAAGC AGGAGGAGAGCACCCGGCAAGGGGCCAGGCAGCTGCATGTGCTGGTGCCTCAAAGCCCGCCCACGGACCTCCCTGGTCTGACCCGGGAGG TCACACAGGACGATCTCGACAGAATCCAGGCCAGCCAGTGGCCGGGGGTGAACGGGTGTCAGGACACACAGGGTAACTGGTATGACTGGA CGCAGTGCATATCGCTCGATCCGCACGGCGACGACGGGCGCTTGAACATTCTGCCTTATGTCTGCTTGGACTGACCGGCCTGTCAGCCAC AAAGTGCATTCCCATCTTGCAGAAGCCGGGTGGGCGGGCAGGCAGGTGGGCAGGTGGCCGGGGCCCAGCTGCCTCCTGCGCTGGGAACTC GGGGAGTCCGGCCCAGGCGGGAGGGAGGGGGCGGGAGTCACGCGGTCTCTCTGCGCTCTTCCCTCAAAACTCTTTTTGTGAAATGCTGCT ACCAGTTTACTAACAAAATTGCGAAGAAGGACCGCGTGGAAGGAAGGACGGCAAAGTGAGTTCAGAACTCTATAGCAAACCAGCTATAAA AAGCGTTAGTCCCTCACCCCCAAAGAGGTGCGGACACTTTCCAGCACCTGAAAGCTGGGGCCTCAGTTGCAGGCAGGCACAGAAAACCTG TGGGAGAGGTCACCTTTAACACAGCAACAGAAGCACGCATCTCATCTCTCTTGCATTTTCTGTTCTTTAATTTGGCCCTGAGTGTCTTGA GACAGTGGGCCATGCCACTGCCTCTGTTTGCTCCCTACCCAGCCACTGTCAGGCCAGTGTTGTCTGTCATGTGCCAGAAGCTTCTCAGCT GTGGTGAGCCACTGGCATTGGGCAGGCGGGCCAGCTGGCCAGCCAGTGTGACCCACACTCCATGGGCAGCCACCTGTTTATATCTGGTTT CAGTTATAACCCAGTTTTTAAAGAAATGCTGCAAAAATTTAAGTTTTCTCATGTTTATTTTAAACAATTCCTCTTCCATCAGACCACCAG ACAAAAAAACCTTTCCTTTCTTCCTCCCTTTTCTTTTTTCCCTTCCTGTACACATCTAGAAAACTTCACCTTTCTAGAGTCCCCCCAAAA CAACACAAAAGTTATTGTGGGTGCTACTGGTTTTATGCTGTACTGTGGGGCGAGGGGGAAGACCTGTCTGTACGCTGGAAACACTCATAA CCATTCCTTTAGATTCGTTTGCCTTATGGTTATTTGTCATAAACGCGATTTGCAAAAACAAGGAGCCTTAGTGAATGTACAGTACCTAGA CTTCTGTGTTCTCAGGACGCAGAAGGGAGCAACTTTGCTATTTGGTCCAGTAAGTGGACACCTTGTGATATAAATGTGGAAATAAAAAAA >23420_23420_1_DNAJB1-MED26_DNAJB1_chr19_14627277_ENST00000254322_MED26_chr19_16689220_ENST00000263390_length(amino acids)=860AA_BP=284 MVGGGAGGRRQRVGGPQEGVMGKDYYQTLGLARGASDEEIKRAYRRQALRYHPDKNKEPGAEEKFKEIAEAYDVLSDPRKREIFDRYGEE GLKGSGPSGGSGGGANGTSFSYTFHGDPHAMFAEFFGGRNPFDTFFGQRNGEEGMDIDDPFSGFPMGMGGFTNVNFGRSRSAQEPARKKQ DPPVTHDLRVSLEEIYSGCTKKMKISHKRLNPDGKSIRNEDKILTIEVKKGWKEGTKITFPKEGDQTSNNIPADIVFVLKDKPHNIFKRD GSDVIYPARISLREIRNMVAVLEVISSLEKYPITKEALEETRLGKLINDVRKKTKNEELAKRAKKLLRSWQKLIEPAHQHEAALRGLAGA TGSANGGAHNCRPEVGAAGPPRSIHDLKSRNDLQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDPLVPNSSPLPTNGISGSPE SFASSLDGSGHAGPEGSRLERDENDKHSGKIPVNAVRPHTSSPGLGKPPGPCLQPKASVLQQLDRVDETPGPPHPKGPPRCSFSPRNSRH EGSFARQQSLYAPKGSVPSPSPRPQALDATQVPSPLPLAQPSTPPVRRLELLPSAESPVCWLEQPESHQRLAGPGCKAGLSPAEPLLSRA GFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVHMEQQSRTELD KQEAKASLQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMSEYLKQEESTRQGARQLHVLVPQSPPTDLPGLTREVTQD -------------------------------------------------------------- >23420_23420_2_DNAJB1-MED26_DNAJB1_chr19_14627277_ENST00000396969_MED26_chr19_16689220_ENST00000263390_length(transcript)=3604nt_BP=765nt AAGCGACGGTTAGGCCAGACGCGGGGGCGGGGTAAGAAGTTGAGTGACAGGCAAGGCAGCATCCACATGACAGGCGGCGCCGAAGGGGTA AATTCTGAGATCCTGCCCCTGAGCTTTCATGAGCTGTTGAACCATCTGGAATTCACAGGCCTGTCATGAGAGACACGATGAGAAGTCCTT AAAGGCCTAAAGGGGAGTGGCCCCAGTGGCGGTAGCGGCGGTGGTGCCAATGGTACCTCTTTCAGCTACACATTCCATGGAGACCCTCAT GCCATGTTTGCTGAGTTCTTCGGTGGCAGAAATCCCTTTGACACCTTTTTTGGGCAGCGGAACGGGGAGGAAGGCATGGACATTGATGAC CCATTCTCTGGCTTCCCTATGGGCATGGGTGGCTTCACCAACGTGAACTTTGGCCGCTCCCGCTCTGCCCAAGAGCCCGCCCGAAAGAAG CAAGATCCCCCAGTCACCCACGACCTTCGAGTCTCCCTTGAAGAGATCTACAGCGGCTGTACCAAGAAGATGAAAATCTCCCACAAGCGG CTAAACCCCGACGGAAAGAGCATTCGAAACGAAGACAAAATATTGACCATCGAAGTGAAGAAGGGGTGGAAAGAAGGAACCAAAATCACT TTCCCCAAGGAAGGAGACCAGACCTCCAACAACATTCCAGCTGATATCGTCTTTGTTTTAAAGGACAAGCCCCACAATATCTTTAAGAGA GATGGCTCTGATGTCATTTATCCTGCCAGGATCAGCCTCCGGGAGATCCGGAACATGGTGGCGGTGCTGGAAGTCATCTCCAGCCTGGAG AAATACCCTATTACCAAAGAGGCACTTGAGGAAACACGACTTGGGAAGCTCATCAACGACGTCCGCAAGAAAACCAAGAACGAGGAGCTC GCCAAGCGGGCCAAGAAGCTGCTGCGGAGCTGGCAGAAGCTCATCGAGCCGGCACACCAGCATGAGGCGGCGCTGCGGGGGCTGGCGGGG GCCACCGGCTCTGCCAACGGGGGCGCACACAACTGCCGGCCGGAGGTGGGGGCGGCTGGCCCACCCAGGAGCATCCATGACCTGAAGAGC CGCAATGACCTCCAGAGGCTGCCCGGGCAGCGGCTGGACAGGCTGGGCAGCCGCAAGCGCCGGGGTGACCAGCGTGACCTCGGCCACCCA GGGCCGCCACCCAAGGTCTCCAAAGCTAGCCACGACCCCCTGGTCCCCAACTCATCCCCCCTCCCCACCAACGGGATCAGTGGGAGTCCA GAGAGCTTCGCCAGCTCCCTGGATGGCAGTGGGCATGCAGGCCCAGAGGGCAGCCGCCTGGAGCGTGACGAGAATGACAAGCACAGTGGC AAGATCCCCGTCAACGCCGTGCGACCGCACACCAGCTCCCCGGGCCTGGGCAAGCCCCCTGGACCCTGCTTGCAGCCAAAGGCTTCGGTG CTGCAGCAGCTGGACAGGGTGGACGAGACTCCGGGGCCTCCCCATCCCAAGGGACCCCCTCGCTGCTCTTTCAGTCCTCGGAACTCACGG CATGAGGGCTCCTTTGCCCGGCAGCAGAGCTTGTATGCACCCAAGGGCTCCGTGCCCAGCCCCTCACCGCGGCCCCAGGCACTCGATGCC ACACAGGTGCCGTCACCGCTTCCACTGGCACAGCCGTCCACACCCCCCGTACGGCGGCTCGAGCTGCTGCCCAGTGCGGAAAGCCCAGTG TGCTGGCTTGAGCAGCCTGAGAGCCACCAGCGGCTGGCGGGGCCGGGCTGCAAGGCAGGGCTGTCCCCAGCCGAGCCCCTCCTGTCCCGG GCAGGCTTTTCCCCAGACTCCTCCAAGGCGGACAGTGATGCTGCCTCCTCAGGGGGCTCGGACAGTAAAAAGAAGAAGAGGTACCGACCT CGAGACTATACGGTTAACTTGGACGGGCAGGTGGCTGAGGCGGGCGTCAAGCCTGTCCGGTTAAAAGAGCGGAAGCTCACCTTTGACCCC ATGACGAGACAGATCAAACCTCTGACCCAGAAAGAGCCAGTGCGGGCAGACAGCCCTGTGCACATGGAGCAGCAGTCCAGGACAGAGCTG GACAAGCAGGAGGCCAAGGCCAGCCTCCAGAGCCCCTTCGAACAGACGAACTGGAAGGAGCTGTCACGCAACGAGATCATCCAGTCCTAC CTGAGCCGGCAGAGCAGCCTGCTCTCATCATCGGGCGCGCAGACCCCAGGGGCTCACCACTTCATGTCTGAGTACCTGAAGCAGGAGGAG AGCACCCGGCAAGGGGCCAGGCAGCTGCATGTGCTGGTGCCTCAAAGCCCGCCCACGGACCTCCCTGGTCTGACCCGGGAGGTCACACAG GACGATCTCGACAGAATCCAGGCCAGCCAGTGGCCGGGGGTGAACGGGTGTCAGGACACACAGGGTAACTGGTATGACTGGACGCAGTGC ATATCGCTCGATCCGCACGGCGACGACGGGCGCTTGAACATTCTGCCTTATGTCTGCTTGGACTGACCGGCCTGTCAGCCACAAAGTGCA TTCCCATCTTGCAGAAGCCGGGTGGGCGGGCAGGCAGGTGGGCAGGTGGCCGGGGCCCAGCTGCCTCCTGCGCTGGGAACTCGGGGAGTC CGGCCCAGGCGGGAGGGAGGGGGCGGGAGTCACGCGGTCTCTCTGCGCTCTTCCCTCAAAACTCTTTTTGTGAAATGCTGCTACCAGTTT ACTAACAAAATTGCGAAGAAGGACCGCGTGGAAGGAAGGACGGCAAAGTGAGTTCAGAACTCTATAGCAAACCAGCTATAAAAAGCGTTA GTCCCTCACCCCCAAAGAGGTGCGGACACTTTCCAGCACCTGAAAGCTGGGGCCTCAGTTGCAGGCAGGCACAGAAAACCTGTGGGAGAG GTCACCTTTAACACAGCAACAGAAGCACGCATCTCATCTCTCTTGCATTTTCTGTTCTTTAATTTGGCCCTGAGTGTCTTGAGACAGTGG GCCATGCCACTGCCTCTGTTTGCTCCCTACCCAGCCACTGTCAGGCCAGTGTTGTCTGTCATGTGCCAGAAGCTTCTCAGCTGTGGTGAG CCACTGGCATTGGGCAGGCGGGCCAGCTGGCCAGCCAGTGTGACCCACACTCCATGGGCAGCCACCTGTTTATATCTGGTTTCAGTTATA ACCCAGTTTTTAAAGAAATGCTGCAAAAATTTAAGTTTTCTCATGTTTATTTTAAACAATTCCTCTTCCATCAGACCACCAGACAAAAAA ACCTTTCCTTTCTTCCTCCCTTTTCTTTTTTCCCTTCCTGTACACATCTAGAAAACTTCACCTTTCTAGAGTCCCCCCAAAACAACACAA AAGTTATTGTGGGTGCTACTGGTTTTATGCTGTACTGTGGGGCGAGGGGGAAGACCTGTCTGTACGCTGGAAACACTCATAACCATTCCT TTAGATTCGTTTGCCTTATGGTTATTTGTCATAAACGCGATTTGCAAAAACAAGGAGCCTTAGTGAATGTACAGTACCTAGACTTCTGTG TTCTCAGGACGCAGAAGGGAGCAACTTTGCTATTTGGTCCAGTAAGTGGACACCTTGTGATATAAATGTGGAAATAAAAAAAAAAAAAAA >23420_23420_2_DNAJB1-MED26_DNAJB1_chr19_14627277_ENST00000396969_MED26_chr19_16689220_ENST00000263390_length(amino acids)=740AA_BP=164 MFAEFFGGRNPFDTFFGQRNGEEGMDIDDPFSGFPMGMGGFTNVNFGRSRSAQEPARKKQDPPVTHDLRVSLEEIYSGCTKKMKISHKRL NPDGKSIRNEDKILTIEVKKGWKEGTKITFPKEGDQTSNNIPADIVFVLKDKPHNIFKRDGSDVIYPARISLREIRNMVAVLEVISSLEK YPITKEALEETRLGKLINDVRKKTKNEELAKRAKKLLRSWQKLIEPAHQHEAALRGLAGATGSANGGAHNCRPEVGAAGPPRSIHDLKSR NDLQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDPLVPNSSPLPTNGISGSPESFASSLDGSGHAGPEGSRLERDENDKHSGK IPVNAVRPHTSSPGLGKPPGPCLQPKASVLQQLDRVDETPGPPHPKGPPRCSFSPRNSRHEGSFARQQSLYAPKGSVPSPSPRPQALDAT QVPSPLPLAQPSTPPVRRLELLPSAESPVCWLEQPESHQRLAGPGCKAGLSPAEPLLSRAGFSPDSSKADSDAASSGGSDSKKKKRYRPR DYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVHMEQQSRTELDKQEAKASLQSPFEQTNWKELSRNEIIQSYL SRQSSLLSSSGAQTPGAHHFMSEYLKQEESTRQGARQLHVLVPQSPPTDLPGLTREVTQDDLDRIQASQWPGVNGCQDTQGNWYDWTQCI -------------------------------------------------------------- >23420_23420_3_DNAJB1-MED26_DNAJB1_chr19_14627278_ENST00000254322_MED26_chr19_16689220_ENST00000263390_length(transcript)=3702nt_BP=863nt AGAGTCCGGGACTGGTCGGCGGCGGAGCCGGGGGACGGCGACAGCGGGTCGGCGGGCCGCAGGAGGGGGTCATGGGTAAAGACTACTACC AGACGTTGGGCCTGGCCCGCGGCGCGTCGGACGAGGAGATCAAGCGGGCCTACCGCCGCCAGGCGCTGCGCTACCACCCGGACAAGAACA AGGAGCCCGGCGCCGAGGAGAAGTTCAAGGAGATCGCTGAGGCCTACGACGTGCTCAGCGACCCGCGCAAGCGCGAGATCTTCGACCGCT ACGGGGAGGAAGGCCTAAAGGGGAGTGGCCCCAGTGGCGGTAGCGGCGGTGGTGCCAATGGTACCTCTTTCAGCTACACATTCCATGGAG ACCCTCATGCCATGTTTGCTGAGTTCTTCGGTGGCAGAAATCCCTTTGACACCTTTTTTGGGCAGCGGAACGGGGAGGAAGGCATGGACA TTGATGACCCATTCTCTGGCTTCCCTATGGGCATGGGTGGCTTCACCAACGTGAACTTTGGCCGCTCCCGCTCTGCCCAAGAGCCCGCCC GAAAGAAGCAAGATCCCCCAGTCACCCACGACCTTCGAGTCTCCCTTGAAGAGATCTACAGCGGCTGTACCAAGAAGATGAAAATCTCCC ACAAGCGGCTAAACCCCGACGGAAAGAGCATTCGAAACGAAGACAAAATATTGACCATCGAAGTGAAGAAGGGGTGGAAAGAAGGAACCA AAATCACTTTCCCCAAGGAAGGAGACCAGACCTCCAACAACATTCCAGCTGATATCGTCTTTGTTTTAAAGGACAAGCCCCACAATATCT TTAAGAGAGATGGCTCTGATGTCATTTATCCTGCCAGGATCAGCCTCCGGGAGATCCGGAACATGGTGGCGGTGCTGGAAGTCATCTCCA GCCTGGAGAAATACCCTATTACCAAAGAGGCACTTGAGGAAACACGACTTGGGAAGCTCATCAACGACGTCCGCAAGAAAACCAAGAACG AGGAGCTCGCCAAGCGGGCCAAGAAGCTGCTGCGGAGCTGGCAGAAGCTCATCGAGCCGGCACACCAGCATGAGGCGGCGCTGCGGGGGC TGGCGGGGGCCACCGGCTCTGCCAACGGGGGCGCACACAACTGCCGGCCGGAGGTGGGGGCGGCTGGCCCACCCAGGAGCATCCATGACC TGAAGAGCCGCAATGACCTCCAGAGGCTGCCCGGGCAGCGGCTGGACAGGCTGGGCAGCCGCAAGCGCCGGGGTGACCAGCGTGACCTCG GCCACCCAGGGCCGCCACCCAAGGTCTCCAAAGCTAGCCACGACCCCCTGGTCCCCAACTCATCCCCCCTCCCCACCAACGGGATCAGTG GGAGTCCAGAGAGCTTCGCCAGCTCCCTGGATGGCAGTGGGCATGCAGGCCCAGAGGGCAGCCGCCTGGAGCGTGACGAGAATGACAAGC ACAGTGGCAAGATCCCCGTCAACGCCGTGCGACCGCACACCAGCTCCCCGGGCCTGGGCAAGCCCCCTGGACCCTGCTTGCAGCCAAAGG CTTCGGTGCTGCAGCAGCTGGACAGGGTGGACGAGACTCCGGGGCCTCCCCATCCCAAGGGACCCCCTCGCTGCTCTTTCAGTCCTCGGA ACTCACGGCATGAGGGCTCCTTTGCCCGGCAGCAGAGCTTGTATGCACCCAAGGGCTCCGTGCCCAGCCCCTCACCGCGGCCCCAGGCAC TCGATGCCACACAGGTGCCGTCACCGCTTCCACTGGCACAGCCGTCCACACCCCCCGTACGGCGGCTCGAGCTGCTGCCCAGTGCGGAAA GCCCAGTGTGCTGGCTTGAGCAGCCTGAGAGCCACCAGCGGCTGGCGGGGCCGGGCTGCAAGGCAGGGCTGTCCCCAGCCGAGCCCCTCC TGTCCCGGGCAGGCTTTTCCCCAGACTCCTCCAAGGCGGACAGTGATGCTGCCTCCTCAGGGGGCTCGGACAGTAAAAAGAAGAAGAGGT ACCGACCTCGAGACTATACGGTTAACTTGGACGGGCAGGTGGCTGAGGCGGGCGTCAAGCCTGTCCGGTTAAAAGAGCGGAAGCTCACCT TTGACCCCATGACGAGACAGATCAAACCTCTGACCCAGAAAGAGCCAGTGCGGGCAGACAGCCCTGTGCACATGGAGCAGCAGTCCAGGA CAGAGCTGGACAAGCAGGAGGCCAAGGCCAGCCTCCAGAGCCCCTTCGAACAGACGAACTGGAAGGAGCTGTCACGCAACGAGATCATCC AGTCCTACCTGAGCCGGCAGAGCAGCCTGCTCTCATCATCGGGCGCGCAGACCCCAGGGGCTCACCACTTCATGTCTGAGTACCTGAAGC AGGAGGAGAGCACCCGGCAAGGGGCCAGGCAGCTGCATGTGCTGGTGCCTCAAAGCCCGCCCACGGACCTCCCTGGTCTGACCCGGGAGG TCACACAGGACGATCTCGACAGAATCCAGGCCAGCCAGTGGCCGGGGGTGAACGGGTGTCAGGACACACAGGGTAACTGGTATGACTGGA CGCAGTGCATATCGCTCGATCCGCACGGCGACGACGGGCGCTTGAACATTCTGCCTTATGTCTGCTTGGACTGACCGGCCTGTCAGCCAC AAAGTGCATTCCCATCTTGCAGAAGCCGGGTGGGCGGGCAGGCAGGTGGGCAGGTGGCCGGGGCCCAGCTGCCTCCTGCGCTGGGAACTC GGGGAGTCCGGCCCAGGCGGGAGGGAGGGGGCGGGAGTCACGCGGTCTCTCTGCGCTCTTCCCTCAAAACTCTTTTTGTGAAATGCTGCT ACCAGTTTACTAACAAAATTGCGAAGAAGGACCGCGTGGAAGGAAGGACGGCAAAGTGAGTTCAGAACTCTATAGCAAACCAGCTATAAA AAGCGTTAGTCCCTCACCCCCAAAGAGGTGCGGACACTTTCCAGCACCTGAAAGCTGGGGCCTCAGTTGCAGGCAGGCACAGAAAACCTG TGGGAGAGGTCACCTTTAACACAGCAACAGAAGCACGCATCTCATCTCTCTTGCATTTTCTGTTCTTTAATTTGGCCCTGAGTGTCTTGA GACAGTGGGCCATGCCACTGCCTCTGTTTGCTCCCTACCCAGCCACTGTCAGGCCAGTGTTGTCTGTCATGTGCCAGAAGCTTCTCAGCT GTGGTGAGCCACTGGCATTGGGCAGGCGGGCCAGCTGGCCAGCCAGTGTGACCCACACTCCATGGGCAGCCACCTGTTTATATCTGGTTT CAGTTATAACCCAGTTTTTAAAGAAATGCTGCAAAAATTTAAGTTTTCTCATGTTTATTTTAAACAATTCCTCTTCCATCAGACCACCAG ACAAAAAAACCTTTCCTTTCTTCCTCCCTTTTCTTTTTTCCCTTCCTGTACACATCTAGAAAACTTCACCTTTCTAGAGTCCCCCCAAAA CAACACAAAAGTTATTGTGGGTGCTACTGGTTTTATGCTGTACTGTGGGGCGAGGGGGAAGACCTGTCTGTACGCTGGAAACACTCATAA CCATTCCTTTAGATTCGTTTGCCTTATGGTTATTTGTCATAAACGCGATTTGCAAAAACAAGGAGCCTTAGTGAATGTACAGTACCTAGA CTTCTGTGTTCTCAGGACGCAGAAGGGAGCAACTTTGCTATTTGGTCCAGTAAGTGGACACCTTGTGATATAAATGTGGAAATAAAAAAA >23420_23420_3_DNAJB1-MED26_DNAJB1_chr19_14627278_ENST00000254322_MED26_chr19_16689220_ENST00000263390_length(amino acids)=860AA_BP=284 MVGGGAGGRRQRVGGPQEGVMGKDYYQTLGLARGASDEEIKRAYRRQALRYHPDKNKEPGAEEKFKEIAEAYDVLSDPRKREIFDRYGEE GLKGSGPSGGSGGGANGTSFSYTFHGDPHAMFAEFFGGRNPFDTFFGQRNGEEGMDIDDPFSGFPMGMGGFTNVNFGRSRSAQEPARKKQ DPPVTHDLRVSLEEIYSGCTKKMKISHKRLNPDGKSIRNEDKILTIEVKKGWKEGTKITFPKEGDQTSNNIPADIVFVLKDKPHNIFKRD GSDVIYPARISLREIRNMVAVLEVISSLEKYPITKEALEETRLGKLINDVRKKTKNEELAKRAKKLLRSWQKLIEPAHQHEAALRGLAGA TGSANGGAHNCRPEVGAAGPPRSIHDLKSRNDLQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDPLVPNSSPLPTNGISGSPE SFASSLDGSGHAGPEGSRLERDENDKHSGKIPVNAVRPHTSSPGLGKPPGPCLQPKASVLQQLDRVDETPGPPHPKGPPRCSFSPRNSRH EGSFARQQSLYAPKGSVPSPSPRPQALDATQVPSPLPLAQPSTPPVRRLELLPSAESPVCWLEQPESHQRLAGPGCKAGLSPAEPLLSRA GFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVHMEQQSRTELD KQEAKASLQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMSEYLKQEESTRQGARQLHVLVPQSPPTDLPGLTREVTQD -------------------------------------------------------------- >23420_23420_4_DNAJB1-MED26_DNAJB1_chr19_14627278_ENST00000396969_MED26_chr19_16689220_ENST00000263390_length(transcript)=3604nt_BP=765nt AAGCGACGGTTAGGCCAGACGCGGGGGCGGGGTAAGAAGTTGAGTGACAGGCAAGGCAGCATCCACATGACAGGCGGCGCCGAAGGGGTA AATTCTGAGATCCTGCCCCTGAGCTTTCATGAGCTGTTGAACCATCTGGAATTCACAGGCCTGTCATGAGAGACACGATGAGAAGTCCTT AAAGGCCTAAAGGGGAGTGGCCCCAGTGGCGGTAGCGGCGGTGGTGCCAATGGTACCTCTTTCAGCTACACATTCCATGGAGACCCTCAT GCCATGTTTGCTGAGTTCTTCGGTGGCAGAAATCCCTTTGACACCTTTTTTGGGCAGCGGAACGGGGAGGAAGGCATGGACATTGATGAC CCATTCTCTGGCTTCCCTATGGGCATGGGTGGCTTCACCAACGTGAACTTTGGCCGCTCCCGCTCTGCCCAAGAGCCCGCCCGAAAGAAG CAAGATCCCCCAGTCACCCACGACCTTCGAGTCTCCCTTGAAGAGATCTACAGCGGCTGTACCAAGAAGATGAAAATCTCCCACAAGCGG CTAAACCCCGACGGAAAGAGCATTCGAAACGAAGACAAAATATTGACCATCGAAGTGAAGAAGGGGTGGAAAGAAGGAACCAAAATCACT TTCCCCAAGGAAGGAGACCAGACCTCCAACAACATTCCAGCTGATATCGTCTTTGTTTTAAAGGACAAGCCCCACAATATCTTTAAGAGA GATGGCTCTGATGTCATTTATCCTGCCAGGATCAGCCTCCGGGAGATCCGGAACATGGTGGCGGTGCTGGAAGTCATCTCCAGCCTGGAG AAATACCCTATTACCAAAGAGGCACTTGAGGAAACACGACTTGGGAAGCTCATCAACGACGTCCGCAAGAAAACCAAGAACGAGGAGCTC GCCAAGCGGGCCAAGAAGCTGCTGCGGAGCTGGCAGAAGCTCATCGAGCCGGCACACCAGCATGAGGCGGCGCTGCGGGGGCTGGCGGGG GCCACCGGCTCTGCCAACGGGGGCGCACACAACTGCCGGCCGGAGGTGGGGGCGGCTGGCCCACCCAGGAGCATCCATGACCTGAAGAGC CGCAATGACCTCCAGAGGCTGCCCGGGCAGCGGCTGGACAGGCTGGGCAGCCGCAAGCGCCGGGGTGACCAGCGTGACCTCGGCCACCCA GGGCCGCCACCCAAGGTCTCCAAAGCTAGCCACGACCCCCTGGTCCCCAACTCATCCCCCCTCCCCACCAACGGGATCAGTGGGAGTCCA GAGAGCTTCGCCAGCTCCCTGGATGGCAGTGGGCATGCAGGCCCAGAGGGCAGCCGCCTGGAGCGTGACGAGAATGACAAGCACAGTGGC AAGATCCCCGTCAACGCCGTGCGACCGCACACCAGCTCCCCGGGCCTGGGCAAGCCCCCTGGACCCTGCTTGCAGCCAAAGGCTTCGGTG CTGCAGCAGCTGGACAGGGTGGACGAGACTCCGGGGCCTCCCCATCCCAAGGGACCCCCTCGCTGCTCTTTCAGTCCTCGGAACTCACGG CATGAGGGCTCCTTTGCCCGGCAGCAGAGCTTGTATGCACCCAAGGGCTCCGTGCCCAGCCCCTCACCGCGGCCCCAGGCACTCGATGCC ACACAGGTGCCGTCACCGCTTCCACTGGCACAGCCGTCCACACCCCCCGTACGGCGGCTCGAGCTGCTGCCCAGTGCGGAAAGCCCAGTG TGCTGGCTTGAGCAGCCTGAGAGCCACCAGCGGCTGGCGGGGCCGGGCTGCAAGGCAGGGCTGTCCCCAGCCGAGCCCCTCCTGTCCCGG GCAGGCTTTTCCCCAGACTCCTCCAAGGCGGACAGTGATGCTGCCTCCTCAGGGGGCTCGGACAGTAAAAAGAAGAAGAGGTACCGACCT CGAGACTATACGGTTAACTTGGACGGGCAGGTGGCTGAGGCGGGCGTCAAGCCTGTCCGGTTAAAAGAGCGGAAGCTCACCTTTGACCCC ATGACGAGACAGATCAAACCTCTGACCCAGAAAGAGCCAGTGCGGGCAGACAGCCCTGTGCACATGGAGCAGCAGTCCAGGACAGAGCTG GACAAGCAGGAGGCCAAGGCCAGCCTCCAGAGCCCCTTCGAACAGACGAACTGGAAGGAGCTGTCACGCAACGAGATCATCCAGTCCTAC CTGAGCCGGCAGAGCAGCCTGCTCTCATCATCGGGCGCGCAGACCCCAGGGGCTCACCACTTCATGTCTGAGTACCTGAAGCAGGAGGAG AGCACCCGGCAAGGGGCCAGGCAGCTGCATGTGCTGGTGCCTCAAAGCCCGCCCACGGACCTCCCTGGTCTGACCCGGGAGGTCACACAG GACGATCTCGACAGAATCCAGGCCAGCCAGTGGCCGGGGGTGAACGGGTGTCAGGACACACAGGGTAACTGGTATGACTGGACGCAGTGC ATATCGCTCGATCCGCACGGCGACGACGGGCGCTTGAACATTCTGCCTTATGTCTGCTTGGACTGACCGGCCTGTCAGCCACAAAGTGCA TTCCCATCTTGCAGAAGCCGGGTGGGCGGGCAGGCAGGTGGGCAGGTGGCCGGGGCCCAGCTGCCTCCTGCGCTGGGAACTCGGGGAGTC CGGCCCAGGCGGGAGGGAGGGGGCGGGAGTCACGCGGTCTCTCTGCGCTCTTCCCTCAAAACTCTTTTTGTGAAATGCTGCTACCAGTTT ACTAACAAAATTGCGAAGAAGGACCGCGTGGAAGGAAGGACGGCAAAGTGAGTTCAGAACTCTATAGCAAACCAGCTATAAAAAGCGTTA GTCCCTCACCCCCAAAGAGGTGCGGACACTTTCCAGCACCTGAAAGCTGGGGCCTCAGTTGCAGGCAGGCACAGAAAACCTGTGGGAGAG GTCACCTTTAACACAGCAACAGAAGCACGCATCTCATCTCTCTTGCATTTTCTGTTCTTTAATTTGGCCCTGAGTGTCTTGAGACAGTGG GCCATGCCACTGCCTCTGTTTGCTCCCTACCCAGCCACTGTCAGGCCAGTGTTGTCTGTCATGTGCCAGAAGCTTCTCAGCTGTGGTGAG CCACTGGCATTGGGCAGGCGGGCCAGCTGGCCAGCCAGTGTGACCCACACTCCATGGGCAGCCACCTGTTTATATCTGGTTTCAGTTATA ACCCAGTTTTTAAAGAAATGCTGCAAAAATTTAAGTTTTCTCATGTTTATTTTAAACAATTCCTCTTCCATCAGACCACCAGACAAAAAA ACCTTTCCTTTCTTCCTCCCTTTTCTTTTTTCCCTTCCTGTACACATCTAGAAAACTTCACCTTTCTAGAGTCCCCCCAAAACAACACAA AAGTTATTGTGGGTGCTACTGGTTTTATGCTGTACTGTGGGGCGAGGGGGAAGACCTGTCTGTACGCTGGAAACACTCATAACCATTCCT TTAGATTCGTTTGCCTTATGGTTATTTGTCATAAACGCGATTTGCAAAAACAAGGAGCCTTAGTGAATGTACAGTACCTAGACTTCTGTG TTCTCAGGACGCAGAAGGGAGCAACTTTGCTATTTGGTCCAGTAAGTGGACACCTTGTGATATAAATGTGGAAATAAAAAAAAAAAAAAA >23420_23420_4_DNAJB1-MED26_DNAJB1_chr19_14627278_ENST00000396969_MED26_chr19_16689220_ENST00000263390_length(amino acids)=740AA_BP=164 MFAEFFGGRNPFDTFFGQRNGEEGMDIDDPFSGFPMGMGGFTNVNFGRSRSAQEPARKKQDPPVTHDLRVSLEEIYSGCTKKMKISHKRL NPDGKSIRNEDKILTIEVKKGWKEGTKITFPKEGDQTSNNIPADIVFVLKDKPHNIFKRDGSDVIYPARISLREIRNMVAVLEVISSLEK YPITKEALEETRLGKLINDVRKKTKNEELAKRAKKLLRSWQKLIEPAHQHEAALRGLAGATGSANGGAHNCRPEVGAAGPPRSIHDLKSR NDLQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDPLVPNSSPLPTNGISGSPESFASSLDGSGHAGPEGSRLERDENDKHSGK IPVNAVRPHTSSPGLGKPPGPCLQPKASVLQQLDRVDETPGPPHPKGPPRCSFSPRNSRHEGSFARQQSLYAPKGSVPSPSPRPQALDAT QVPSPLPLAQPSTPPVRRLELLPSAESPVCWLEQPESHQRLAGPGCKAGLSPAEPLLSRAGFSPDSSKADSDAASSGGSDSKKKKRYRPR DYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVHMEQQSRTELDKQEAKASLQSPFEQTNWKELSRNEIIQSYL SRQSSLLSSSGAQTPGAHHFMSEYLKQEESTRQGARQLHVLVPQSPPTDLPGLTREVTQDDLDRIQASQWPGVNGCQDTQGNWYDWTQCI -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for DNAJB1-MED26 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DNAJB1-MED26 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DNAJB1-MED26 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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