|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:DNAJB9-DENND5B (FusionGDB2 ID:23438) |
Fusion Gene Summary for DNAJB9-DENND5B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DNAJB9-DENND5B | Fusion gene ID: 23438 | Hgene | Tgene | Gene symbol | DNAJB9 | DENND5B | Gene ID | 4189 | 160518 |
| Gene name | DnaJ heat shock protein family (Hsp40) member B9 | DENN domain containing 5B | |
| Synonyms | ERdj4|MDG-1|MDG1|MST049|MSTP049 | - | |
| Cytomap | 7q31.1|14q24.2-q24.3 | 12p11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dnaJ homolog subfamily B member 9DnaJ (Hsp40) homolog, subfamily B, member 9ER-resident protein ERdj4endoplasmic reticulum DNA J domain-containing protein 4endoplasmic reticulum DnaJ homolog 4microvascular endothelial differentiation gene 1 protein | DENN domain-containing protein 5BDENN/MADD domain containing 5Brab6IP1-like protein | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9UBS3 | Q6ZUT9 | |
| Ensembl transtripts involved in fusion gene | ENST00000465725, ENST00000249356, | ENST00000306833, ENST00000354285, ENST00000389082, ENST00000536562, ENST00000545147, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 6 X 6 X 4=144 |
| # samples | 4 | 6 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DNAJB9 [Title/Abstract] AND DENND5B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DNAJB9(108212387)-DENND5B(31648853), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across DNAJB9 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across DENND5B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | OV | TCGA-25-1317 | DNAJB9 | chr7 | 108212387 | + | DENND5B | chr12 | 31648853 | - |
Top |
Fusion Gene ORF analysis for DNAJB9-DENND5B |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000465725 | ENST00000306833 | DNAJB9 | chr7 | 108212387 | + | DENND5B | chr12 | 31648853 | - |
| 3UTR-3CDS | ENST00000465725 | ENST00000354285 | DNAJB9 | chr7 | 108212387 | + | DENND5B | chr12 | 31648853 | - |
| 3UTR-3CDS | ENST00000465725 | ENST00000389082 | DNAJB9 | chr7 | 108212387 | + | DENND5B | chr12 | 31648853 | - |
| 3UTR-3CDS | ENST00000465725 | ENST00000536562 | DNAJB9 | chr7 | 108212387 | + | DENND5B | chr12 | 31648853 | - |
| 3UTR-5UTR | ENST00000465725 | ENST00000545147 | DNAJB9 | chr7 | 108212387 | + | DENND5B | chr12 | 31648853 | - |
| 5CDS-5UTR | ENST00000249356 | ENST00000545147 | DNAJB9 | chr7 | 108212387 | + | DENND5B | chr12 | 31648853 | - |
| In-frame | ENST00000249356 | ENST00000306833 | DNAJB9 | chr7 | 108212387 | + | DENND5B | chr12 | 31648853 | - |
| In-frame | ENST00000249356 | ENST00000354285 | DNAJB9 | chr7 | 108212387 | + | DENND5B | chr12 | 31648853 | - |
| In-frame | ENST00000249356 | ENST00000389082 | DNAJB9 | chr7 | 108212387 | + | DENND5B | chr12 | 31648853 | - |
| In-frame | ENST00000249356 | ENST00000536562 | DNAJB9 | chr7 | 108212387 | + | DENND5B | chr12 | 31648853 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000249356 | DNAJB9 | chr7 | 108212387 | + | ENST00000306833 | DENND5B | chr12 | 31648853 | - | 9841 | 763 | 546 | 4460 | 1304 |
| ENST00000249356 | DNAJB9 | chr7 | 108212387 | + | ENST00000389082 | DENND5B | chr12 | 31648853 | - | 9841 | 763 | 546 | 4460 | 1304 |
| ENST00000249356 | DNAJB9 | chr7 | 108212387 | + | ENST00000536562 | DENND5B | chr12 | 31648853 | - | 4671 | 763 | 546 | 4460 | 1304 |
| ENST00000249356 | DNAJB9 | chr7 | 108212387 | + | ENST00000354285 | DENND5B | chr12 | 31648853 | - | 3522 | 763 | 546 | 2786 | 746 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000249356 | ENST00000306833 | DNAJB9 | chr7 | 108212387 | + | DENND5B | chr12 | 31648853 | - | 0.000234338 | 0.9997657 |
| ENST00000249356 | ENST00000389082 | DNAJB9 | chr7 | 108212387 | + | DENND5B | chr12 | 31648853 | - | 0.000234338 | 0.9997657 |
| ENST00000249356 | ENST00000536562 | DNAJB9 | chr7 | 108212387 | + | DENND5B | chr12 | 31648853 | - | 0.001979968 | 0.99802005 |
| ENST00000249356 | ENST00000354285 | DNAJB9 | chr7 | 108212387 | + | DENND5B | chr12 | 31648853 | - | 0.000825354 | 0.99917465 |
Top |
Fusion Genomic Features for DNAJB9-DENND5B |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for DNAJB9-DENND5B |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:108212387/chr12:31648853) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DNAJB9 | DENND5B |
| FUNCTION: Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:18400946). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity). {ECO:0000250|UniProtKB:G3H0N9, ECO:0000250|UniProtKB:Q9QYI6, ECO:0000269|PubMed:18400946}. | FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | DENND5B | chr7:108212387 | chr12:31648853 | ENST00000354285 | 1 | 9 | 1118_1267 | 64 | 739.0 | Domain | RUN 2 | |
| Tgene | DENND5B | chr7:108212387 | chr12:31648853 | ENST00000354285 | 1 | 9 | 263_399 | 64 | 739.0 | Domain | cDENN | |
| Tgene | DENND5B | chr7:108212387 | chr12:31648853 | ENST00000354285 | 1 | 9 | 401_581 | 64 | 739.0 | Domain | dDENN | |
| Tgene | DENND5B | chr7:108212387 | chr12:31648853 | ENST00000354285 | 1 | 9 | 772_932 | 64 | 739.0 | Domain | RUN 1 | |
| Tgene | DENND5B | chr7:108212387 | chr12:31648853 | ENST00000354285 | 1 | 9 | 936_1044 | 64 | 739.0 | Domain | PLAT | |
| Tgene | DENND5B | chr7:108212387 | chr12:31648853 | ENST00000389082 | 0 | 21 | 1118_1267 | 42 | 1275.0 | Domain | RUN 2 | |
| Tgene | DENND5B | chr7:108212387 | chr12:31648853 | ENST00000389082 | 0 | 21 | 263_399 | 42 | 1275.0 | Domain | cDENN | |
| Tgene | DENND5B | chr7:108212387 | chr12:31648853 | ENST00000389082 | 0 | 21 | 401_581 | 42 | 1275.0 | Domain | dDENN | |
| Tgene | DENND5B | chr7:108212387 | chr12:31648853 | ENST00000389082 | 0 | 21 | 772_932 | 42 | 1275.0 | Domain | RUN 1 | |
| Tgene | DENND5B | chr7:108212387 | chr12:31648853 | ENST00000389082 | 0 | 21 | 936_1044 | 42 | 1275.0 | Domain | PLAT | |
| Tgene | DENND5B | chr7:108212387 | chr12:31648853 | ENST00000354285 | 1 | 9 | 916_936 | 64 | 739.0 | Transmembrane | Helical | |
| Tgene | DENND5B | chr7:108212387 | chr12:31648853 | ENST00000389082 | 0 | 21 | 916_936 | 42 | 1275.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DNAJB9 | chr7:108212387 | chr12:31648853 | ENST00000249356 | + | 2 | 3 | 26_90 | 72 | 224.0 | Domain | J |
| Hgene | DNAJB9 | chr7:108212387 | chr12:31648853 | ENST00000249356 | + | 2 | 3 | 91_223 | 72 | 224.0 | Region | Divergent targeting domain |
| Tgene | DENND5B | chr7:108212387 | chr12:31648853 | ENST00000354285 | 1 | 9 | 39_244 | 64 | 739.0 | Domain | uDENN | |
| Tgene | DENND5B | chr7:108212387 | chr12:31648853 | ENST00000389082 | 0 | 21 | 39_244 | 42 | 1275.0 | Domain | uDENN |
Top |
Fusion Gene Sequence for DNAJB9-DENND5B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >23438_23438_1_DNAJB9-DENND5B_DNAJB9_chr7_108212387_ENST00000249356_DENND5B_chr12_31648853_ENST00000306833_length(transcript)=9841nt_BP=763nt ATGACTCGGGTGAGGCCCCTGGAGACCGGGGCCGGCGACGGATGCAGGGCGGCCCTCCTCACTGAGGATGCGCCACAGGTCCAGGCCTCT CGAGCCCCTGCGCCTGCGCTAGCATTCTGCCGGGAAAGCCGCCTCGTCTGTCGACTCACTTCCGCCTCCTCCGGTTTAAGCACCGCCTTT TCGGGGGTTGAAGCCGGAAGTGGCGCACAGCCCTAGCAGCAACAACAGTTTTCCACGTGCGCGTAGGGCGCCGGGATCACGTGGGGAGGC AGAAGCCAATGGGGAAGCGTTTCGTGTAGGTCTTCTGAGGTGGTGGCGCCAGCGGCTACCTCCTGCCTGTGAGGAGCTGGCTGAGAGGGG ACTGGGCGCCGGCGGGGAAGGAGGAGCGCTAGGTCGGTGTACGACCGAGATTAGGGTGCGTGCCAGCTCCGGGAGGCCGCGGTGAGGGGC CGGGCCCAAGCTGCCGACCCGAGCCGATCGTCAGGGTCGCCAGCGCCTCAGCTCTGTGGAGGAGCAGCAGTAGTCGGAGGGTGCAGGATA TTAGAAATGGCTACTCCCCAGTCAATTTTCATCTTTGCAATCTGCATTTTAATGATAACAGAATTAATTCTGGCCTCAAAAAGCTACTAT GATATCTTAGGTGTGCCAAAATCGGCATCAGAGCGCCAAATCAAGAAGGCCTTTCACAAGTTGGCCATGAAGTACCACCCTGACAAAAAT AAGAGCCCGGATGCTGAAGCAAAATTCAGAGAGATTGCAGAAGGCGAAAATTTTGACCAGAGTCCTTTGAGAAGAACATTCAAATCCAAA GTTCTCGCCCACTATCCTCAGAATATAGAATGGAACCCTTTTGATCAAGATGCGGTGAACATGTTGTGCATGCCTAAAGGGCTATCTTTC AGGACACAAACGGACAATAAAGACCCCCAGTTTCACTCATTTATAATTACCAGGGAAGATGGTTCTCGCACCTATGGTTTTGTTCTCACT TTTTATGAAGAAGTTACAAGTAAGCAAATCTGCACAGCAATGCAGACACTTTACCAGATGCACAACGCTGAGCATTACAGCAGTGTGTAT GCTTCATCTTCCTGCAGTATGGACTCATTGGCAAGTAGTCTTGATGAAGGAGATACAACTTCCCTTTTGAAACTCCAGCGATACAACTCC TATGATATTAGCAGAGACACCCTGTATGTTTCAAAAAGTATATGCTTGATCACACCGTTACCATTCATGCAGGCCTGCAAGAAATTCCTT ATCCAGCTTTACAAGGCTGTTACCTCACAGCAGCCACCACCCTTGCCACTTGAAAGCTATATCCACAATATTCTTTATGAAGTACCCCTT CCACCTCCAGGGAGGTCACTGAAATTTTATGGTGTTTATGAACCTGTCATCTGCCAGAGGCCTGGGCCCAGTGAACTCCCCCTCTCTGAT TACCCCCTTCGGGAGGCATTTGAGCTCCTGGGATTAGAGAACCTGGTGCAGGTGTTTACCTGTGTTCTTTTAGAGATGCAAATCCTTCTC TACTCACAAGATTATCAACGCCTGATGACTGTGGCAGAAGGCATCACCACACTTTTGTTCCCATTTCAATGGCAACATGTTTATGTGCCC ATTCTACCTGCTTCTCTGCTACATTTTCTTGATGCTCCTGTCCCTTATCTGATGGGCCTTCAGTCAAAAGAAGGAACTGACCGTTCTAAA CTAGAACTTCCTCAAGAGGCTAATTTGTGTTTTGTGGACATTGACAACCATTTTATTGAGTTGCCTGAAGAATTTCCACAGTTCCCCAAT AAAGTGGATTTTATCCAAGAACTCTCTGAGGTTCTTGTTCAATTTGGGATCCCTCCTGAGGGCAGCCTACATTGCAGTGAGAGTACCAGC AAACTGAAGAATATGGTTCTGAAAGACTTGGTCAATGACAAAAAGAACGGCAATGTCTGTACTAATAACATCAGCATGTATGAGTTACTG AAGGGCAATGAAACCATAGCCCGCTTGCAGGCTCTGGCCAAGCGTACTGGTGTGGCTGTGGAAAAAATGGACCTCTCTGCTTCTCTGGGT GAAAAAGACAAGGATTTAAAACTGCATTGTGAAGAGGCAGAACTAAGGGACTACCAGCTCAATGTACAGCTCCGAGAGGTCTTTGCTAAC CGTTTTACACAGATGTTTGCAGATTACGAAGCATTTGTCATTCAGACTGCCCAGGACATGGAATCCTGGCTGACCAACCGGGAACAGATG CAGAACTTTGACAAAGCTTCCTTTCTGTCTGACCAGCCTGAGCCTTACCTGCCATTTCTTTCACGCTTCATTGAAACACAGATGTTTGCC ACCTTTATTGATAATAAAATTATGTCTCAGTGGGAAGAGAAAGATCCTTTGCTTCGGGTCTTTGACACTCGGATTGATAAGATAAGGCTG TATAATGTAAGGGCACCCACCTTGCGGACATCTATATATCAGAAATGCAGCACTTTAAAAGAAGCAGCCCAATCAATTGAGCAGAGACTG ATGAAAATGGATCACACTGCAATCCACCCACATCTACTTGATATGAAAATTGGTCAAGGCAAATATGAGCAGGGGTTCTTTCCAAAGTTA CAGTCCGATGTCTTGGCAACAGGACCAACCAGTAACAATCGCTGGGTAAGTCGGAGTGCCACTGCACAGCGCAGGAAAGAACGCCTTCGC CAGCATTCTGAGCATGTTGGGCTGGACAACGACTTGAGGGAGAAATATATGCAAGAGGCACGAAGTTTAGGAAAAAACCTGAGGCAACCC AAACTGTCAGACCTCTCTCCTGCAGTTATTGCACAGACCAACTGTAAATTCGTAGAAGGCTTATTAAAAGAATGTAGAATGAAGACAAAG CGCATGTTGGTGGAGAAGATGGGACATGAAGCGGTGGAACTTGGCCATGGAGAAGCAAACATCACCGGCCTGGAGGAGAACACCTTGATC GCCAGCCTTTGTGACCTGCTGGAGAGGATATGGAGCCATGGCTTGCAGGTCAAGCAGGGGAAGTCGGCTTTGTGGTCACATTTAATTCAA TTTCAGGACAGAGAAGAGAAACAAGAGCACCTTGCAGAATCACCAGTTGCCCTCGGACCAGAAAGAAGAAAATCTGACTCAGGAGTTATG TTGCCAACGCTCAGGGTCTCTCTTATTCAGGACATGAGGCATATTCAAAACATGAGTGAGATCAAGACTGATGTTGGACGAGCTCGGGCG TGGATAAGACTGTCTCTAGAAAAGAAGCTCTTGTCCCAGCATCTTAAGCAGTTGCTTTCTAACCAACCACTCACCAAGAAGCTTTATAAG CGATATGCTTTTCTACGTTGCGAAGAAGAAAGAGAGCAGTTTCTTTACCACCTTCTTTCTCTCAATGCTGTGGACTATTTCTGCTTCACC AGTGTGTTCACCACTATCATGATTCCGTATAGGTCAGTGATCATCCCAATCAAAAAGCTGAGCAATGCAATAATCACATCAAACCCTTGG ATCTGTGTATCAGGAGAGCTGGGAGACACAGGAGTAATGCAGATTCCCAAAAACCTCCTCGAAATGACCTTTGAGTGCCAGAACTTGGGG AAGCTGACCACTGTTCAGATTGGTCACGATAACTCAGGACTGTTAGCCAAATGGCTAGTGGATTGTGTCATGGTCAGAAATGAAATCACA GGACATACATACAGATTCCCATGTGGGCGGTGGCTGGGGAAAGGCATTGATGATGGGAGCCTGGAGAGAATTCTTATTGGAGAGTTGATG ACATCAGCATCAGATGAAGATCTAGTAAAGCAGTGTCGGACTCCACCCCAGCAGAAGTCACCCACCACGGCTAGGAGATTGAGCATCACT TCACTGACAGGAAAAAACAACAAACCCAATGCTGGGCAGATACAAGAAGGAATTGGAGAAGCTGTGAACAATATTGTGAAACATTTTCAT AAACCTGAAAAAGAGAGAGGAAGCCTCACCGTGTTGCTGTGTGGAGAAAATGGCCTGGTTGCAGCCCTTGAGCAAGTTTTCCACCATGGG TTCAAATCTGCCCGCATCTTTCACAAGAATGTCTTCATCTGGGACTTCATAGAGAAAGTGGTTGCTTATTTTGAAACAACTGACCAGATT CTAGATAATGAAGATGATGTCCTTATTCAGAAATCATCCTGCAAAACCTTCTGCCACTACGTAAATGCTATTAATACTGCACCCAGGAAC ATTGGGAAGGATGGCAAATTCCAGATTTTAGTTTGCCTTGGAACAAGGGATCGCCTGCTCCCACAGTGGATTCCATTGTTAGCTGAGTGT CCTGCCATCACTCGAATGTATGAAGAGAGCGCTCTCCTGCGAGACCGCATGACTGTCAACTCCCTTATCCGAATTCTGCAGACCATTCAG GACTTCACCATAGTCCTAGAAGGATCACTCATCAAAGGAGTGGATGTGTAACCCAACTGGCTAGAAACTCTCAGTCCAAACCTTGCTCCT TCCCCAACTAGGGGACCGATTTGGACTTGTCTGACAGTAGTGAGTCACTGCAGGGGCAGCCAAACATATGCCCCATTTGGAACAATCCTC ACTCTACAGACAAGGCAAAATGTTGTATTGTAGTTCATTTGAACCTGGAATTTAGTATAAAATAGAGTATTTTCATGTGTTAGATGTGTG TAAATATGCTATCTTCTTTAAGAAATTATATTACTCTAATAAGATGCTTTTCTTAGATTGAATATTCCTGTGACTTAAAATAAGTAGCTT AAAAATGTTGGGGGTTGGGGGGAAGAGTGGTGCTAGCCAGGAAGAAGCCAGTAAACATGTAAATATAGTGCAACCCAGTCGGGCTTTTTT TTTTCTCCAGGTATCACAAAGAAACCCAGAATGCATTGTTATGTAGTAGCCATCCATCTTGGAGTCTGATCCTTTGTATTGTGGATGCAC ACAGCTTTACCTACTGTACTGGTAGTCTTCACTTCTATCTTTTAAGTTACAAACTGTTTTATATATTTGAATCGCTAGTCACTTTTCCAG TCTTTTGGAAAAAAATTTCAGTCCGCACAAGATGATATAATTGGAGTATTTTAAACACTAGACCCCAGGAGCTTGGCTGAACTGGAAAGA GAACATACAAAGCTCTGAGAAATGTGTTCAATTGTGGGATTATAACTTCTTTACACTTCGGAAAGATTAGCCTAGACTAACTTCATTCTT GGCATTTTTATTCTTGTTATTTGAGGTACTTTGGGAAGATGTGAATTTCAGTGTTAGATTCATAGTGATAAGAACTGCAAACAGCAATTT GATTCTGTACTTTTAATTTGGCCATCTAAACTGTGCAGTGGTCTACCTCTTAAGGATAACCATGAGCCCTGTCTTTGTTAGGGTCTAATC ACCCACCTCTCCAGGGCCCATCCCCCCTCGGGAAATGGAAGGAATGTCTAAGGAGGAGGAGGGCTGTGTGTGGCTTGGAATGTTTTTGTG AAAGCATTTGTTGACCATGATAATGCAAATAACAGAAGGAGAGAGAGAATGAACCCTTTCTGGGTGTTTCAGGGCAAGCTTTACGTTCCT TTGTAGGAAGGGGAGTAATAATGTAAAACAACTGACCCAGAGAAGCTAAAAGCCACTGGCAGCACAGGCTGACAAAATGGAAGCAAAGCA AGAGGTGGCAACAATTTTGAAAGACCAAAAGTTGTGAGTAACTTTCCAGTTTGATAGTTTATAAAGAAGTTAAGTAAATGTAGTATTGGC TAGTTACTGTAAGTCCTCATCTTCTGGTAGGTCCTGTAACTCTAATTAGGCATTTGTACATTTTTAGCAGCAAAATTGCCTCAGCAGAGC TCCCAGTTTTATTCCCAGTTGTGGCTGAAAAGCAAAGCCATGGCATCAGTATCCTTGTGCAATCGGAGGTTGCTGGGCTTTCACCACCTG TGTTGTTAACCTTATTTCCTGGAGGAAGAAACAGATGAAACAAGTGCCTAACTCCCTTTATCAAACACAGCCAAGGACAGCCTCTTTTAA CATGTGACTTCATACTTGAGGAAAAGGAGAGTTGACAGCTGTATTTAAAAACCCATGGAGCCGGGTGCGGTGGCTCACGCCTATGATCCC AGCACTTTGGGAGGCCGAGGCAGGCGGATCACAAGGTCAGGAGATTGAGACCCTCCTGGCTAACACCGTGAAACCCCGTCTCTACTAAAA ATACAAAAAATTAGCCGGGCGTGGTGGCGGGTGCCTGTACAGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGCGAGGCGGAGCTTGCAG TAAGCTGAGATCGCGCCACTGCCCTCCAGCCTGGGCAACAGAGCAAGACTCCATCTCAAAAAATAAATAGATAAAAATAAAAACCCATGG AAATGGTTTAAGAAAATGGTTCTGGGTACACCAGAAATTTGTTTGCCTGAAGCTAAAGTGTGTCTACAATGGTACAGCTCTTCCAGGGAC ATGGGAAGTTTATCGTGGGAGATATCCAGAACCTGTTTTACACTGGGCTCCTACTGTGTTTGGTGATCAGAAACTATAGAGGGGTCCAAC CCAGGATTTCATGTTTGTATCTTCATAAGGCCATGCTCCTGACAGGTCTAGGCAACCTGGGGGATGACTTAGGTTAATGTGCTAGGATTG ACACACCTCATCCAGCCTTCTTACTTTGTGGATGGGAACACTTAAGGAATAGAGAGATTAAATCTTACACTTACCCCACAGCTGGTTACT GACAACACAAGCTCTAGAATTCATGTTTGTTTGTTTGTTTTATTTCACCAGGCTGCATGAGACTGACCTTCCGGCATTCTTACTAATAGT CTTTCTATTATACTATTGGATCTTTATTCATCCACCTATACAAGTAGGAAATAAGGATGAATATTCATTTAGAAGAATTAATATTCATAT TAACACATTGCTCTCAGATTATTGGGAATTAACATCTTGTAAAAACTGGGAGCAGGCCAGGTACGGTGGCTAACGCCTGTAATCCTGACA CTTTGGGAGTCTGAGGCGGGTGGTTCATCTGAGGTCAGTCGGGAGTTCAAGACCAGACTGGCCAACATGGTGAAACCCCGTCTCTACTAA AAAAAAAAAATAGACAAAAATTAGCGGGGGGGTGGTGGCAGGGCCTGTAATTCCAGCTACTCAGGAGGCTGAAGCAGGAGAATCGTTTAA ACACAGGAGGTGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAACCTGGGTGACAAGAGCGAGACTCCGTCTCAAAAAAAAAA AAAGAAAAAAACTGCAGCCAAAGTTGGATTTGCGGCCTATGAATAAAACCATTACTTTAAAAAGTAATACCCCCAAAAAAGTTACACCTG AAGTTTCATCTTCATGCCTTTGTGTAATATTACTATAATGGTGAAATGATGATTTAAAAAAAACACATCAGAACTGACACATCCTCTTGG ATGATGGGTCCTTCAGTCACCTTGTGAGCCCATGTACTTATTCCGTTGATACAGCCTGTGCTATAAACATGTGGGGCCCTCCTTGTGTGA GCTGCTTGAATGGCCAGTACCCCCATTCTTTTGAATATTCCCAATGGCAGTCAATCTTGGCCTTTAAGAATAAATTTAAATATTTGGAAA TAGTCCTTAGGATCCAAGTTTGATCAATGAAAAGGATGCTTAAGCTGAGTTTGGGGTCACATAAGAAGTGCAGTTATAAAGAAATAAGAC ATGTTGGGCATGGCAGTACACACCTGTAGTCCCAGCTGCTTGGGAAGCCAAGGCAGGAGGATCACTTCAACCCAGGAGTTTGAGTCCAGC CTGGGTAACATAGGGAAACCCCATCTCAAAAAAACAAAACAAAGGACTTAGTTTTTATGTGGCTCATAAGTGTCTCTAAGTTATACCAAA AGTTTGAGCACAACAGTAGTAGCAGAATGCTTAGAATAAATGCTTGACTTTTAAGCTGACTTTTGGAAGGACCATACCCACATAGAGGCA TCTTTTCTGCTGTGGTAATTTTTTAAATTAATACATTGCTTTAGGATTACATCTCAAAGTAAATAAAAAAATCAATATTTAATTTGTTTT TTTCCTGCAAATAAATTAAATGCTGGGACCATAATGATTATTTTTGCATAGTAATAGCTGGTGAAGAAGTTGTTTTAAAATTAAATTGCC AAAAGTATTACCTCTTGAAAAATTTATTTTCCCAAAGTTTTTCATATGTCATGAAACCCCTAATCTTGACCTTTATGACACAGTGGCATT ACACTGATGTTGGAAGCATGTGTGAGATCTGTGCCCTGGTCGGGAGTCATATGCCTTAAAAATGACTGCGAGTCAGTGTGAAGTAGTATA AAGTGGAGTCCTACGTGGGAAAAAGCAGGCTACTGAGGACAAAAACCTCCCAACCCTCCCCACCTTGTTTTCCACTGGGAATGAGAATTT GATATGAGAAACTTCAACCTTGCAGAAGTGTGGATTTCCCTCTGAAATTTAAATGTTTCACACATTTTTGTACCTTTTGTAACCTTGTGG TATTTACTTTCACATGGCTTTTTAAAAAATTATTTTAATGAACTTCTATCACACTATATGAATGATATGGGGGAAATACTGAACTGCTCA TATTTCCTTTTTTGGCAATAAAGCACTGTTATATGTAAATGTAAGTGAAAAAGAGGTTCAAGACTATACAACAGCTTATGTGTAGTATAT GTTGACATCCCTAAGGTATTTTGAAACATGAGGTGACAGACAAGGACCTCAAATTTCCAGGGAAATATTTATTTCACAACATTAGGAGTG TAGCTCTTCATAATGAAATATCTTCTTTCTGCTAAAGATTACAATTTTTCATTTAGGGAACTGTGAATATTTTCTGTGAGGTTTACAGAA ACTAGTGTATCCTTTTCACTATGTTGAAAAGACAATCTGAACTTTAGCTATTTATATTTCAGTATTAACACACCTTCACTGATTGAGAGT CTTGAGCCCTTCTCTACTTTTATAAAGTGAATCCTATTTCCAAGTCATCCATGTCTTTTGAAGTCTGTTTCTTATATAAGTATTTATTAC TTTACTGTTTAGCATAAATAGGAGACAGAAAAGGATAATAAACTACTAGGTCCTTTATTCCTATTAAAATAAATTTATAAATCCCTTGAA TCAACTGAATTCTAAGCTTTTTGAAGAGGTTGCTGATGTAGTGTGATCAAAAGAATCTAAGGAGAACCTCCTCTCCAAAATCTGATTGGA GCTGTTCACCCTCTCAAGGACAAGATAAAGATTGACTTCAGAGATATATCACATCAAGCTAGAGGAAAAAAAAAAAACCTCAAATAAAAT TTTTCCTCATTCGAAGGGATCCAGGGTATCCTTGGGTTATGTAGGAGGGAATCATATTTGTTCTAATTTACCTGAATGTACTTGTGTGTG AATCCAATCTTGATTCTAAACACCAAATCTTGTCAACAGTAGAGAAGTATAGTAAGGAGTTCCTGTTGTCAATCAAATGAGGGTGTGAAA CATTTAGAATGCTCTGTGTTACACTTGAACCATGTATAAATGTAACCTGTGTATCTTTTTTTTAATTAGCTTTTCTGAATTTAAATTATA TTGTTTTTCTTTGTATTGTTAGCAAAATGCATCAGAACTGGATTTTTTTTCTCATCTGAACATAATATAAAATTTGAAAGAGTATTGTGA TATTAAGCACTTTAACATACATATCAGACAAACTGACGTGGGTTTTTCAGGTTTGGGAGTACATTTAAATATGACTTTTCATGCTTTGTT >23438_23438_1_DNAJB9-DENND5B_DNAJB9_chr7_108212387_ENST00000249356_DENND5B_chr12_31648853_ENST00000306833_length(amino acids)=1304AA_BP=72 MATPQSIFIFAICILMITELILASKSYYDILGVPKSASERQIKKAFHKLAMKYHPDKNKSPDAEAKFREIAEGENFDQSPLRRTFKSKVL AHYPQNIEWNPFDQDAVNMLCMPKGLSFRTQTDNKDPQFHSFIITREDGSRTYGFVLTFYEEVTSKQICTAMQTLYQMHNAEHYSSVYAS SSCSMDSLASSLDEGDTTSLLKLQRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYIHNILYEVPLPP PGRSLKFYGVYEPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPIL PASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQELSEVLVQFGIPPEGSLHCSESTSKL KNMVLKDLVNDKKNGNVCTNNISMYELLKGNETIARLQALAKRTGVAVEKMDLSASLGEKDKDLKLHCEEAELRDYQLNVQLREVFANRF TQMFADYEAFVIQTAQDMESWLTNREQMQNFDKASFLSDQPEPYLPFLSRFIETQMFATFIDNKIMSQWEEKDPLLRVFDTRIDKIRLYN VRAPTLRTSIYQKCSTLKEAAQSIEQRLMKMDHTAIHPHLLDMKIGQGKYEQGFFPKLQSDVLATGPTSNNRWVSRSATAQRRKERLRQH SEHVGLDNDLREKYMQEARSLGKNLRQPKLSDLSPAVIAQTNCKFVEGLLKECRMKTKRMLVEKMGHEAVELGHGEANITGLEENTLIAS LCDLLERIWSHGLQVKQGKSALWSHLIQFQDREEKQEHLAESPVALGPERRKSDSGVMLPTLRVSLIQDMRHIQNMSEIKTDVGRARAWI RLSLEKKLLSQHLKQLLSNQPLTKKLYKRYAFLRCEEEREQFLYHLLSLNAVDYFCFTSVFTTIMIPYRSVIIPIKKLSNAIITSNPWIC VSGELGDTGVMQIPKNLLEMTFECQNLGKLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLERILIGELMTS ASDEDLVKQCRTPPQQKSPTTARRLSITSLTGKNNKPNAGQIQEGIGEAVNNIVKHFHKPEKERGSLTVLLCGENGLVAALEQVFHHGFK SARIFHKNVFIWDFIEKVVAYFETTDQILDNEDDVLIQKSSCKTFCHYVNAINTAPRNIGKDGKFQILVCLGTRDRLLPQWIPLLAECPA -------------------------------------------------------------- >23438_23438_2_DNAJB9-DENND5B_DNAJB9_chr7_108212387_ENST00000249356_DENND5B_chr12_31648853_ENST00000354285_length(transcript)=3522nt_BP=763nt ATGACTCGGGTGAGGCCCCTGGAGACCGGGGCCGGCGACGGATGCAGGGCGGCCCTCCTCACTGAGGATGCGCCACAGGTCCAGGCCTCT CGAGCCCCTGCGCCTGCGCTAGCATTCTGCCGGGAAAGCCGCCTCGTCTGTCGACTCACTTCCGCCTCCTCCGGTTTAAGCACCGCCTTT TCGGGGGTTGAAGCCGGAAGTGGCGCACAGCCCTAGCAGCAACAACAGTTTTCCACGTGCGCGTAGGGCGCCGGGATCACGTGGGGAGGC AGAAGCCAATGGGGAAGCGTTTCGTGTAGGTCTTCTGAGGTGGTGGCGCCAGCGGCTACCTCCTGCCTGTGAGGAGCTGGCTGAGAGGGG ACTGGGCGCCGGCGGGGAAGGAGGAGCGCTAGGTCGGTGTACGACCGAGATTAGGGTGCGTGCCAGCTCCGGGAGGCCGCGGTGAGGGGC CGGGCCCAAGCTGCCGACCCGAGCCGATCGTCAGGGTCGCCAGCGCCTCAGCTCTGTGGAGGAGCAGCAGTAGTCGGAGGGTGCAGGATA TTAGAAATGGCTACTCCCCAGTCAATTTTCATCTTTGCAATCTGCATTTTAATGATAACAGAATTAATTCTGGCCTCAAAAAGCTACTAT GATATCTTAGGTGTGCCAAAATCGGCATCAGAGCGCCAAATCAAGAAGGCCTTTCACAAGTTGGCCATGAAGTACCACCCTGACAAAAAT AAGAGCCCGGATGCTGAAGCAAAATTCAGAGAGATTGCAGAAGGCGAAAATTTTGACCAGAGTCCTTTGAGAAGAACATTCAAATCCAAA GTTCTCGCCCACTATCCTCAGAATATAGAATGGAACCCTTTTGATCAAGATGCGGTGAACATGTTGTGCATGCCTAAAGGGCTATCTTTC AGGACACAAACGGACAATAAAGACCCCCAGTTTCACTCATTTATAATTACCAGGGAAGATGGTTCTCGCACCTATGGTTTTGTTCTCACT TTTTATGAAGAAGTTACAAGTAAGCAAATCTGCACAGCAATGCAGACACTTTACCAGATGCACAACGCTGAGCATTACAGCAGTGTGTAT GCTTCATCTTCCTGCAGTATGGACTCATTGGCAAGTAGTCTTGATGAAGGAGATACAACTTCCCTTTTGAAACTCCAGCGATACAACTCC TATGATATTAGCAGAGACACCCTGTATGTTTCAAAAAGTATATGCTTGATCACACCGTTACCATTCATGCAGGCCTGCAAGAAATTCCTT ATCCAGCTTTACAAGGCTGTTACCTCACAGCAGCCACCACCCTTGCCACTTGAAAGCTATATCCACAATATTCTTTATGAAGTACCCCTT CCACCTCCAGGGAGGTCACTGAAATTTTATGGTGTTTATGAACCTGTCATCTGCCAGAGGCCTGGGCCCAGTGAACTCCCCCTCTCTGAT TACCCCCTTCGGGAGGCATTTGAGCTCCTGGGATTAGAGAACCTGGTGCAGGTGTTTACCTGTGTTCTTTTAGAGATGCAAATCCTTCTC TACTCACAAGATTATCAACGCCTGATGACTGTGGCAGAAGGCATCACCACACTTTTGTTCCCATTTCAATGGCAACATGTTTATGTGCCC ATTCTACCTGCTTCTCTGCTACATTTTCTTGATGCTCCTGTCCCTTATCTGATGGGCCTTCAGTCAAAAGAAGGAACTGACCGTTCTAAA CTAGAACTTCCTCAAGAGGCTAATTTGTGTTTTGTGGACATTGACAACCATTTTATTGAGTTGCCTGAAGAATTTCCACAGTTCCCCAAT AAAGTGGATTTTATCCAAGAACTCTCTGAGGTTCTTGTTCAATTTGGGATCCCTCCTGAGGGCAGCCTACATTGCAGTGAGAGTACCAGC AAACTGAAGAATATGGTTCTGAAAGACTTGGTCAATGACAAAAAGAACGGCAATGTCTGTACTAATAACATCAGCATGTATGAGTTACTG AAGGGCAATGAAACCATAGCCCGCTTGCAGGCTCTGGCCAAGCGTACTGGTGTGGCTGTGGAAAAAATGGACCTCTCTGCTTCTCTGGGT GAAAAAGACAAGGATTTAAAACTGCATTGTGAAGAGGCAGAACTAAGGGACTACCAGCTCAATGTACAGCTCCGAGAGGTCTTTGCTAAC CGTTTTACACAGATGTTTGCAGATTACGAAGCATTTGTCATTCAGACTGCCCAGGACATGGAATCCTGGCTGACCAACCGGGAACAGATG CAGAACTTTGACAAAGCTTCCTTTCTGTCTGACCAGCCTGAGCCTTACCTGCCATTTCTTTCACGCTTCATTGAAACACAGATGTTTGCC ACCTTTATTGATAATAAAATTATGTCTCAGTGGGAAGAGAAAGATCCTTTGCTTCGGGTCTTTGACACTCGGATTGATAAGATAAGGCTG TATAATGTAAGGGCACCCACCTTGCGGACATCTATATATCAGAAATGCAGCACTTTAAAAGAAGCAGCCCAATCAATTGAGCAGAGACTG ATGAAAATGGATCACACTGCAATCCACCCACATCTACTTGATATGAAAATTGGTCAAGGCAAATATGAGCAGGGGTTCTTTCCAAAGTTA CAGTCCGATGTCTTGGCAACAGGACCAACCAGTAACAATCGCTGGGTAAGTCGGAGTGCCACTGCACAGCGCAGGAAAGAACGCCTTCGC CAGCATTCTGAGCATGTTGGGCTGGACAACGACTTGAGGGAGGTATGTGGTCTACCTTCCTGGGGTGCCTCACAGCAAGCGCCATGAACT AGGCTTATTCCTTCCAGCAGATGTCATTGTGTAGATTCTTAATGTTCTTTAAAAAAAAAACTGTTTAGTTATAGTTTAAAATATTAATCC TTTTGTACGGACATATAGCAGAAAACACCCTTTTTTCCATTTTTGTAATTTCAAGACATCTATAATAAGGCTCTAAAACAAGTCTTTCTG TGTATTACATCAAGTAAAGATCAAGTTGAGGATAAATTTTTAGTTACTATGTCTCCTATAGGAGAAAAATTGTCTGCATGAGAAGCCTAG ACATTTCTAAGTTTCAAGCATAATTATAAGGAGTAGTGTGATGTACTTGCCTATGCTTTGTTCTTGGCTTGCTGGCACCAGTTTTTTTTC TTGAATCTCTAAATCTACTTTATATTTTTGAAAGTGTTTTAAAACTATTTTTAAATTAAGATCCTTACACTTTTATTTGTACTCTTTGAA AATAAGACCATAATTATACAACAAGTAAGTTTTGATTTTTTTCTGTGTGAAATCTGCATATATATATAGTGTCTTGCTATGTTGCCCAGG TCTTGAACTCCTGGGCTCAAGCAGTGCTCCTGCCTCAGCCTCCCAAAGTATTGGGATTACAGGTGTGAGCTGCCATGCCCAGCCTGATTG TTTCGTTTCTTATGATCAAAAGAGAAATGCAATCAGAAGACTTGTTAACTGTTTTCTAGTATCAAATTTGTAAAAATAAAGCAGAAAACA >23438_23438_2_DNAJB9-DENND5B_DNAJB9_chr7_108212387_ENST00000249356_DENND5B_chr12_31648853_ENST00000354285_length(amino acids)=746AA_BP=72 MATPQSIFIFAICILMITELILASKSYYDILGVPKSASERQIKKAFHKLAMKYHPDKNKSPDAEAKFREIAEGENFDQSPLRRTFKSKVL AHYPQNIEWNPFDQDAVNMLCMPKGLSFRTQTDNKDPQFHSFIITREDGSRTYGFVLTFYEEVTSKQICTAMQTLYQMHNAEHYSSVYAS SSCSMDSLASSLDEGDTTSLLKLQRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYIHNILYEVPLPP PGRSLKFYGVYEPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPIL PASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQELSEVLVQFGIPPEGSLHCSESTSKL KNMVLKDLVNDKKNGNVCTNNISMYELLKGNETIARLQALAKRTGVAVEKMDLSASLGEKDKDLKLHCEEAELRDYQLNVQLREVFANRF TQMFADYEAFVIQTAQDMESWLTNREQMQNFDKASFLSDQPEPYLPFLSRFIETQMFATFIDNKIMSQWEEKDPLLRVFDTRIDKIRLYN VRAPTLRTSIYQKCSTLKEAAQSIEQRLMKMDHTAIHPHLLDMKIGQGKYEQGFFPKLQSDVLATGPTSNNRWVSRSATAQRRKERLRQH -------------------------------------------------------------- >23438_23438_3_DNAJB9-DENND5B_DNAJB9_chr7_108212387_ENST00000249356_DENND5B_chr12_31648853_ENST00000389082_length(transcript)=9841nt_BP=763nt ATGACTCGGGTGAGGCCCCTGGAGACCGGGGCCGGCGACGGATGCAGGGCGGCCCTCCTCACTGAGGATGCGCCACAGGTCCAGGCCTCT CGAGCCCCTGCGCCTGCGCTAGCATTCTGCCGGGAAAGCCGCCTCGTCTGTCGACTCACTTCCGCCTCCTCCGGTTTAAGCACCGCCTTT TCGGGGGTTGAAGCCGGAAGTGGCGCACAGCCCTAGCAGCAACAACAGTTTTCCACGTGCGCGTAGGGCGCCGGGATCACGTGGGGAGGC AGAAGCCAATGGGGAAGCGTTTCGTGTAGGTCTTCTGAGGTGGTGGCGCCAGCGGCTACCTCCTGCCTGTGAGGAGCTGGCTGAGAGGGG ACTGGGCGCCGGCGGGGAAGGAGGAGCGCTAGGTCGGTGTACGACCGAGATTAGGGTGCGTGCCAGCTCCGGGAGGCCGCGGTGAGGGGC CGGGCCCAAGCTGCCGACCCGAGCCGATCGTCAGGGTCGCCAGCGCCTCAGCTCTGTGGAGGAGCAGCAGTAGTCGGAGGGTGCAGGATA TTAGAAATGGCTACTCCCCAGTCAATTTTCATCTTTGCAATCTGCATTTTAATGATAACAGAATTAATTCTGGCCTCAAAAAGCTACTAT GATATCTTAGGTGTGCCAAAATCGGCATCAGAGCGCCAAATCAAGAAGGCCTTTCACAAGTTGGCCATGAAGTACCACCCTGACAAAAAT AAGAGCCCGGATGCTGAAGCAAAATTCAGAGAGATTGCAGAAGGCGAAAATTTTGACCAGAGTCCTTTGAGAAGAACATTCAAATCCAAA GTTCTCGCCCACTATCCTCAGAATATAGAATGGAACCCTTTTGATCAAGATGCGGTGAACATGTTGTGCATGCCTAAAGGGCTATCTTTC AGGACACAAACGGACAATAAAGACCCCCAGTTTCACTCATTTATAATTACCAGGGAAGATGGTTCTCGCACCTATGGTTTTGTTCTCACT TTTTATGAAGAAGTTACAAGTAAGCAAATCTGCACAGCAATGCAGACACTTTACCAGATGCACAACGCTGAGCATTACAGCAGTGTGTAT GCTTCATCTTCCTGCAGTATGGACTCATTGGCAAGTAGTCTTGATGAAGGAGATACAACTTCCCTTTTGAAACTCCAGCGATACAACTCC TATGATATTAGCAGAGACACCCTGTATGTTTCAAAAAGTATATGCTTGATCACACCGTTACCATTCATGCAGGCCTGCAAGAAATTCCTT ATCCAGCTTTACAAGGCTGTTACCTCACAGCAGCCACCACCCTTGCCACTTGAAAGCTATATCCACAATATTCTTTATGAAGTACCCCTT CCACCTCCAGGGAGGTCACTGAAATTTTATGGTGTTTATGAACCTGTCATCTGCCAGAGGCCTGGGCCCAGTGAACTCCCCCTCTCTGAT TACCCCCTTCGGGAGGCATTTGAGCTCCTGGGATTAGAGAACCTGGTGCAGGTGTTTACCTGTGTTCTTTTAGAGATGCAAATCCTTCTC TACTCACAAGATTATCAACGCCTGATGACTGTGGCAGAAGGCATCACCACACTTTTGTTCCCATTTCAATGGCAACATGTTTATGTGCCC ATTCTACCTGCTTCTCTGCTACATTTTCTTGATGCTCCTGTCCCTTATCTGATGGGCCTTCAGTCAAAAGAAGGAACTGACCGTTCTAAA CTAGAACTTCCTCAAGAGGCTAATTTGTGTTTTGTGGACATTGACAACCATTTTATTGAGTTGCCTGAAGAATTTCCACAGTTCCCCAAT AAAGTGGATTTTATCCAAGAACTCTCTGAGGTTCTTGTTCAATTTGGGATCCCTCCTGAGGGCAGCCTACATTGCAGTGAGAGTACCAGC AAACTGAAGAATATGGTTCTGAAAGACTTGGTCAATGACAAAAAGAACGGCAATGTCTGTACTAATAACATCAGCATGTATGAGTTACTG AAGGGCAATGAAACCATAGCCCGCTTGCAGGCTCTGGCCAAGCGTACTGGTGTGGCTGTGGAAAAAATGGACCTCTCTGCTTCTCTGGGT GAAAAAGACAAGGATTTAAAACTGCATTGTGAAGAGGCAGAACTAAGGGACTACCAGCTCAATGTACAGCTCCGAGAGGTCTTTGCTAAC CGTTTTACACAGATGTTTGCAGATTACGAAGCATTTGTCATTCAGACTGCCCAGGACATGGAATCCTGGCTGACCAACCGGGAACAGATG CAGAACTTTGACAAAGCTTCCTTTCTGTCTGACCAGCCTGAGCCTTACCTGCCATTTCTTTCACGCTTCATTGAAACACAGATGTTTGCC ACCTTTATTGATAATAAAATTATGTCTCAGTGGGAAGAGAAAGATCCTTTGCTTCGGGTCTTTGACACTCGGATTGATAAGATAAGGCTG TATAATGTAAGGGCACCCACCTTGCGGACATCTATATATCAGAAATGCAGCACTTTAAAAGAAGCAGCCCAATCAATTGAGCAGAGACTG ATGAAAATGGATCACACTGCAATCCACCCACATCTACTTGATATGAAAATTGGTCAAGGCAAATATGAGCAGGGGTTCTTTCCAAAGTTA CAGTCCGATGTCTTGGCAACAGGACCAACCAGTAACAATCGCTGGGTAAGTCGGAGTGCCACTGCACAGCGCAGGAAAGAACGCCTTCGC CAGCATTCTGAGCATGTTGGGCTGGACAACGACTTGAGGGAGAAATATATGCAAGAGGCACGAAGTTTAGGAAAAAACCTGAGGCAACCC AAACTGTCAGACCTCTCTCCTGCAGTTATTGCACAGACCAACTGTAAATTCGTAGAAGGCTTATTAAAAGAATGTAGAATGAAGACAAAG CGCATGTTGGTGGAGAAGATGGGACATGAAGCGGTGGAACTTGGCCATGGAGAAGCAAACATCACCGGCCTGGAGGAGAACACCTTGATC GCCAGCCTTTGTGACCTGCTGGAGAGGATATGGAGCCATGGCTTGCAGGTCAAGCAGGGGAAGTCGGCTTTGTGGTCACATTTAATTCAA TTTCAGGACAGAGAAGAGAAACAAGAGCACCTTGCAGAATCACCAGTTGCCCTCGGACCAGAAAGAAGAAAATCTGACTCAGGAGTTATG TTGCCAACGCTCAGGGTCTCTCTTATTCAGGACATGAGGCATATTCAAAACATGAGTGAGATCAAGACTGATGTTGGACGAGCTCGGGCG TGGATAAGACTGTCTCTAGAAAAGAAGCTCTTGTCCCAGCATCTTAAGCAGTTGCTTTCTAACCAACCACTCACCAAGAAGCTTTATAAG CGATATGCTTTTCTACGTTGCGAAGAAGAAAGAGAGCAGTTTCTTTACCACCTTCTTTCTCTCAATGCTGTGGACTATTTCTGCTTCACC AGTGTGTTCACCACTATCATGATTCCGTATAGGTCAGTGATCATCCCAATCAAAAAGCTGAGCAATGCAATAATCACATCAAACCCTTGG ATCTGTGTATCAGGAGAGCTGGGAGACACAGGAGTAATGCAGATTCCCAAAAACCTCCTCGAAATGACCTTTGAGTGCCAGAACTTGGGG AAGCTGACCACTGTTCAGATTGGTCACGATAACTCAGGACTGTTAGCCAAATGGCTAGTGGATTGTGTCATGGTCAGAAATGAAATCACA GGACATACATACAGATTCCCATGTGGGCGGTGGCTGGGGAAAGGCATTGATGATGGGAGCCTGGAGAGAATTCTTATTGGAGAGTTGATG ACATCAGCATCAGATGAAGATCTAGTAAAGCAGTGTCGGACTCCACCCCAGCAGAAGTCACCCACCACGGCTAGGAGATTGAGCATCACT TCACTGACAGGAAAAAACAACAAACCCAATGCTGGGCAGATACAAGAAGGAATTGGAGAAGCTGTGAACAATATTGTGAAACATTTTCAT AAACCTGAAAAAGAGAGAGGAAGCCTCACCGTGTTGCTGTGTGGAGAAAATGGCCTGGTTGCAGCCCTTGAGCAAGTTTTCCACCATGGG TTCAAATCTGCCCGCATCTTTCACAAGAATGTCTTCATCTGGGACTTCATAGAGAAAGTGGTTGCTTATTTTGAAACAACTGACCAGATT CTAGATAATGAAGATGATGTCCTTATTCAGAAATCATCCTGCAAAACCTTCTGCCACTACGTAAATGCTATTAATACTGCACCCAGGAAC ATTGGGAAGGATGGCAAATTCCAGATTTTAGTTTGCCTTGGAACAAGGGATCGCCTGCTCCCACAGTGGATTCCATTGTTAGCTGAGTGT CCTGCCATCACTCGAATGTATGAAGAGAGCGCTCTCCTGCGAGACCGCATGACTGTCAACTCCCTTATCCGAATTCTGCAGACCATTCAG GACTTCACCATAGTCCTAGAAGGATCACTCATCAAAGGAGTGGATGTGTAACCCAACTGGCTAGAAACTCTCAGTCCAAACCTTGCTCCT TCCCCAACTAGGGGACCGATTTGGACTTGTCTGACAGTAGTGAGTCACTGCAGGGGCAGCCAAACATATGCCCCATTTGGAACAATCCTC ACTCTACAGACAAGGCAAAATGTTGTATTGTAGTTCATTTGAACCTGGAATTTAGTATAAAATAGAGTATTTTCATGTGTTAGATGTGTG TAAATATGCTATCTTCTTTAAGAAATTATATTACTCTAATAAGATGCTTTTCTTAGATTGAATATTCCTGTGACTTAAAATAAGTAGCTT AAAAATGTTGGGGGTTGGGGGGAAGAGTGGTGCTAGCCAGGAAGAAGCCAGTAAACATGTAAATATAGTGCAACCCAGTCGGGCTTTTTT TTTTCTCCAGGTATCACAAAGAAACCCAGAATGCATTGTTATGTAGTAGCCATCCATCTTGGAGTCTGATCCTTTGTATTGTGGATGCAC ACAGCTTTACCTACTGTACTGGTAGTCTTCACTTCTATCTTTTAAGTTACAAACTGTTTTATATATTTGAATCGCTAGTCACTTTTCCAG TCTTTTGGAAAAAAATTTCAGTCCGCACAAGATGATATAATTGGAGTATTTTAAACACTAGACCCCAGGAGCTTGGCTGAACTGGAAAGA GAACATACAAAGCTCTGAGAAATGTGTTCAATTGTGGGATTATAACTTCTTTACACTTCGGAAAGATTAGCCTAGACTAACTTCATTCTT GGCATTTTTATTCTTGTTATTTGAGGTACTTTGGGAAGATGTGAATTTCAGTGTTAGATTCATAGTGATAAGAACTGCAAACAGCAATTT GATTCTGTACTTTTAATTTGGCCATCTAAACTGTGCAGTGGTCTACCTCTTAAGGATAACCATGAGCCCTGTCTTTGTTAGGGTCTAATC ACCCACCTCTCCAGGGCCCATCCCCCCTCGGGAAATGGAAGGAATGTCTAAGGAGGAGGAGGGCTGTGTGTGGCTTGGAATGTTTTTGTG AAAGCATTTGTTGACCATGATAATGCAAATAACAGAAGGAGAGAGAGAATGAACCCTTTCTGGGTGTTTCAGGGCAAGCTTTACGTTCCT TTGTAGGAAGGGGAGTAATAATGTAAAACAACTGACCCAGAGAAGCTAAAAGCCACTGGCAGCACAGGCTGACAAAATGGAAGCAAAGCA AGAGGTGGCAACAATTTTGAAAGACCAAAAGTTGTGAGTAACTTTCCAGTTTGATAGTTTATAAAGAAGTTAAGTAAATGTAGTATTGGC TAGTTACTGTAAGTCCTCATCTTCTGGTAGGTCCTGTAACTCTAATTAGGCATTTGTACATTTTTAGCAGCAAAATTGCCTCAGCAGAGC TCCCAGTTTTATTCCCAGTTGTGGCTGAAAAGCAAAGCCATGGCATCAGTATCCTTGTGCAATCGGAGGTTGCTGGGCTTTCACCACCTG TGTTGTTAACCTTATTTCCTGGAGGAAGAAACAGATGAAACAAGTGCCTAACTCCCTTTATCAAACACAGCCAAGGACAGCCTCTTTTAA CATGTGACTTCATACTTGAGGAAAAGGAGAGTTGACAGCTGTATTTAAAAACCCATGGAGCCGGGTGCGGTGGCTCACGCCTATGATCCC AGCACTTTGGGAGGCCGAGGCAGGCGGATCACAAGGTCAGGAGATTGAGACCCTCCTGGCTAACACCGTGAAACCCCGTCTCTACTAAAA ATACAAAAAATTAGCCGGGCGTGGTGGCGGGTGCCTGTACAGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGCGAGGCGGAGCTTGCAG TAAGCTGAGATCGCGCCACTGCCCTCCAGCCTGGGCAACAGAGCAAGACTCCATCTCAAAAAATAAATAGATAAAAATAAAAACCCATGG AAATGGTTTAAGAAAATGGTTCTGGGTACACCAGAAATTTGTTTGCCTGAAGCTAAAGTGTGTCTACAATGGTACAGCTCTTCCAGGGAC ATGGGAAGTTTATCGTGGGAGATATCCAGAACCTGTTTTACACTGGGCTCCTACTGTGTTTGGTGATCAGAAACTATAGAGGGGTCCAAC CCAGGATTTCATGTTTGTATCTTCATAAGGCCATGCTCCTGACAGGTCTAGGCAACCTGGGGGATGACTTAGGTTAATGTGCTAGGATTG ACACACCTCATCCAGCCTTCTTACTTTGTGGATGGGAACACTTAAGGAATAGAGAGATTAAATCTTACACTTACCCCACAGCTGGTTACT GACAACACAAGCTCTAGAATTCATGTTTGTTTGTTTGTTTTATTTCACCAGGCTGCATGAGACTGACCTTCCGGCATTCTTACTAATAGT CTTTCTATTATACTATTGGATCTTTATTCATCCACCTATACAAGTAGGAAATAAGGATGAATATTCATTTAGAAGAATTAATATTCATAT TAACACATTGCTCTCAGATTATTGGGAATTAACATCTTGTAAAAACTGGGAGCAGGCCAGGTACGGTGGCTAACGCCTGTAATCCTGACA CTTTGGGAGTCTGAGGCGGGTGGTTCATCTGAGGTCAGTCGGGAGTTCAAGACCAGACTGGCCAACATGGTGAAACCCCGTCTCTACTAA AAAAAAAAAATAGACAAAAATTAGCGGGGGGGTGGTGGCAGGGCCTGTAATTCCAGCTACTCAGGAGGCTGAAGCAGGAGAATCGTTTAA ACACAGGAGGTGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAACCTGGGTGACAAGAGCGAGACTCCGTCTCAAAAAAAAAA AAAGAAAAAAACTGCAGCCAAAGTTGGATTTGCGGCCTATGAATAAAACCATTACTTTAAAAAGTAATACCCCCAAAAAAGTTACACCTG AAGTTTCATCTTCATGCCTTTGTGTAATATTACTATAATGGTGAAATGATGATTTAAAAAAAACACATCAGAACTGACACATCCTCTTGG ATGATGGGTCCTTCAGTCACCTTGTGAGCCCATGTACTTATTCCGTTGATACAGCCTGTGCTATAAACATGTGGGGCCCTCCTTGTGTGA GCTGCTTGAATGGCCAGTACCCCCATTCTTTTGAATATTCCCAATGGCAGTCAATCTTGGCCTTTAAGAATAAATTTAAATATTTGGAAA TAGTCCTTAGGATCCAAGTTTGATCAATGAAAAGGATGCTTAAGCTGAGTTTGGGGTCACATAAGAAGTGCAGTTATAAAGAAATAAGAC ATGTTGGGCATGGCAGTACACACCTGTAGTCCCAGCTGCTTGGGAAGCCAAGGCAGGAGGATCACTTCAACCCAGGAGTTTGAGTCCAGC CTGGGTAACATAGGGAAACCCCATCTCAAAAAAACAAAACAAAGGACTTAGTTTTTATGTGGCTCATAAGTGTCTCTAAGTTATACCAAA AGTTTGAGCACAACAGTAGTAGCAGAATGCTTAGAATAAATGCTTGACTTTTAAGCTGACTTTTGGAAGGACCATACCCACATAGAGGCA TCTTTTCTGCTGTGGTAATTTTTTAAATTAATACATTGCTTTAGGATTACATCTCAAAGTAAATAAAAAAATCAATATTTAATTTGTTTT TTTCCTGCAAATAAATTAAATGCTGGGACCATAATGATTATTTTTGCATAGTAATAGCTGGTGAAGAAGTTGTTTTAAAATTAAATTGCC AAAAGTATTACCTCTTGAAAAATTTATTTTCCCAAAGTTTTTCATATGTCATGAAACCCCTAATCTTGACCTTTATGACACAGTGGCATT ACACTGATGTTGGAAGCATGTGTGAGATCTGTGCCCTGGTCGGGAGTCATATGCCTTAAAAATGACTGCGAGTCAGTGTGAAGTAGTATA AAGTGGAGTCCTACGTGGGAAAAAGCAGGCTACTGAGGACAAAAACCTCCCAACCCTCCCCACCTTGTTTTCCACTGGGAATGAGAATTT GATATGAGAAACTTCAACCTTGCAGAAGTGTGGATTTCCCTCTGAAATTTAAATGTTTCACACATTTTTGTACCTTTTGTAACCTTGTGG TATTTACTTTCACATGGCTTTTTAAAAAATTATTTTAATGAACTTCTATCACACTATATGAATGATATGGGGGAAATACTGAACTGCTCA TATTTCCTTTTTTGGCAATAAAGCACTGTTATATGTAAATGTAAGTGAAAAAGAGGTTCAAGACTATACAACAGCTTATGTGTAGTATAT GTTGACATCCCTAAGGTATTTTGAAACATGAGGTGACAGACAAGGACCTCAAATTTCCAGGGAAATATTTATTTCACAACATTAGGAGTG TAGCTCTTCATAATGAAATATCTTCTTTCTGCTAAAGATTACAATTTTTCATTTAGGGAACTGTGAATATTTTCTGTGAGGTTTACAGAA ACTAGTGTATCCTTTTCACTATGTTGAAAAGACAATCTGAACTTTAGCTATTTATATTTCAGTATTAACACACCTTCACTGATTGAGAGT CTTGAGCCCTTCTCTACTTTTATAAAGTGAATCCTATTTCCAAGTCATCCATGTCTTTTGAAGTCTGTTTCTTATATAAGTATTTATTAC TTTACTGTTTAGCATAAATAGGAGACAGAAAAGGATAATAAACTACTAGGTCCTTTATTCCTATTAAAATAAATTTATAAATCCCTTGAA TCAACTGAATTCTAAGCTTTTTGAAGAGGTTGCTGATGTAGTGTGATCAAAAGAATCTAAGGAGAACCTCCTCTCCAAAATCTGATTGGA GCTGTTCACCCTCTCAAGGACAAGATAAAGATTGACTTCAGAGATATATCACATCAAGCTAGAGGAAAAAAAAAAAACCTCAAATAAAAT TTTTCCTCATTCGAAGGGATCCAGGGTATCCTTGGGTTATGTAGGAGGGAATCATATTTGTTCTAATTTACCTGAATGTACTTGTGTGTG AATCCAATCTTGATTCTAAACACCAAATCTTGTCAACAGTAGAGAAGTATAGTAAGGAGTTCCTGTTGTCAATCAAATGAGGGTGTGAAA CATTTAGAATGCTCTGTGTTACACTTGAACCATGTATAAATGTAACCTGTGTATCTTTTTTTTAATTAGCTTTTCTGAATTTAAATTATA TTGTTTTTCTTTGTATTGTTAGCAAAATGCATCAGAACTGGATTTTTTTTCTCATCTGAACATAATATAAAATTTGAAAGAGTATTGTGA TATTAAGCACTTTAACATACATATCAGACAAACTGACGTGGGTTTTTCAGGTTTGGGAGTACATTTAAATATGACTTTTCATGCTTTGTT >23438_23438_3_DNAJB9-DENND5B_DNAJB9_chr7_108212387_ENST00000249356_DENND5B_chr12_31648853_ENST00000389082_length(amino acids)=1304AA_BP=72 MATPQSIFIFAICILMITELILASKSYYDILGVPKSASERQIKKAFHKLAMKYHPDKNKSPDAEAKFREIAEGENFDQSPLRRTFKSKVL AHYPQNIEWNPFDQDAVNMLCMPKGLSFRTQTDNKDPQFHSFIITREDGSRTYGFVLTFYEEVTSKQICTAMQTLYQMHNAEHYSSVYAS SSCSMDSLASSLDEGDTTSLLKLQRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYIHNILYEVPLPP PGRSLKFYGVYEPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPIL PASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQELSEVLVQFGIPPEGSLHCSESTSKL KNMVLKDLVNDKKNGNVCTNNISMYELLKGNETIARLQALAKRTGVAVEKMDLSASLGEKDKDLKLHCEEAELRDYQLNVQLREVFANRF TQMFADYEAFVIQTAQDMESWLTNREQMQNFDKASFLSDQPEPYLPFLSRFIETQMFATFIDNKIMSQWEEKDPLLRVFDTRIDKIRLYN VRAPTLRTSIYQKCSTLKEAAQSIEQRLMKMDHTAIHPHLLDMKIGQGKYEQGFFPKLQSDVLATGPTSNNRWVSRSATAQRRKERLRQH SEHVGLDNDLREKYMQEARSLGKNLRQPKLSDLSPAVIAQTNCKFVEGLLKECRMKTKRMLVEKMGHEAVELGHGEANITGLEENTLIAS LCDLLERIWSHGLQVKQGKSALWSHLIQFQDREEKQEHLAESPVALGPERRKSDSGVMLPTLRVSLIQDMRHIQNMSEIKTDVGRARAWI RLSLEKKLLSQHLKQLLSNQPLTKKLYKRYAFLRCEEEREQFLYHLLSLNAVDYFCFTSVFTTIMIPYRSVIIPIKKLSNAIITSNPWIC VSGELGDTGVMQIPKNLLEMTFECQNLGKLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLERILIGELMTS ASDEDLVKQCRTPPQQKSPTTARRLSITSLTGKNNKPNAGQIQEGIGEAVNNIVKHFHKPEKERGSLTVLLCGENGLVAALEQVFHHGFK SARIFHKNVFIWDFIEKVVAYFETTDQILDNEDDVLIQKSSCKTFCHYVNAINTAPRNIGKDGKFQILVCLGTRDRLLPQWIPLLAECPA -------------------------------------------------------------- >23438_23438_4_DNAJB9-DENND5B_DNAJB9_chr7_108212387_ENST00000249356_DENND5B_chr12_31648853_ENST00000536562_length(transcript)=4671nt_BP=763nt ATGACTCGGGTGAGGCCCCTGGAGACCGGGGCCGGCGACGGATGCAGGGCGGCCCTCCTCACTGAGGATGCGCCACAGGTCCAGGCCTCT CGAGCCCCTGCGCCTGCGCTAGCATTCTGCCGGGAAAGCCGCCTCGTCTGTCGACTCACTTCCGCCTCCTCCGGTTTAAGCACCGCCTTT TCGGGGGTTGAAGCCGGAAGTGGCGCACAGCCCTAGCAGCAACAACAGTTTTCCACGTGCGCGTAGGGCGCCGGGATCACGTGGGGAGGC AGAAGCCAATGGGGAAGCGTTTCGTGTAGGTCTTCTGAGGTGGTGGCGCCAGCGGCTACCTCCTGCCTGTGAGGAGCTGGCTGAGAGGGG ACTGGGCGCCGGCGGGGAAGGAGGAGCGCTAGGTCGGTGTACGACCGAGATTAGGGTGCGTGCCAGCTCCGGGAGGCCGCGGTGAGGGGC CGGGCCCAAGCTGCCGACCCGAGCCGATCGTCAGGGTCGCCAGCGCCTCAGCTCTGTGGAGGAGCAGCAGTAGTCGGAGGGTGCAGGATA TTAGAAATGGCTACTCCCCAGTCAATTTTCATCTTTGCAATCTGCATTTTAATGATAACAGAATTAATTCTGGCCTCAAAAAGCTACTAT GATATCTTAGGTGTGCCAAAATCGGCATCAGAGCGCCAAATCAAGAAGGCCTTTCACAAGTTGGCCATGAAGTACCACCCTGACAAAAAT AAGAGCCCGGATGCTGAAGCAAAATTCAGAGAGATTGCAGAAGGCGAAAATTTTGACCAGAGTCCTTTGAGAAGAACATTCAAATCCAAA GTTCTCGCCCACTATCCTCAGAATATAGAATGGAACCCTTTTGATCAAGATGCGGTGAACATGTTGTGCATGCCTAAAGGGCTATCTTTC AGGACACAAACGGACAATAAAGACCCCCAGTTTCACTCATTTATAATTACCAGGGAAGATGGTTCTCGCACCTATGGTTTTGTTCTCACT TTTTATGAAGAAGTTACAAGTAAGCAAATCTGCACAGCAATGCAGACACTTTACCAGATGCACAACGCTGAGCATTACAGCAGTGTGTAT GCTTCATCTTCCTGCAGTATGGACTCATTGGCAAGTAGTCTTGATGAAGGAGATACAACTTCCCTTTTGAAACTCCAGCGATACAACTCC TATGATATTAGCAGAGACACCCTGTATGTTTCAAAAAGTATATGCTTGATCACACCGTTACCATTCATGCAGGCCTGCAAGAAATTCCTT ATCCAGCTTTACAAGGCTGTTACCTCACAGCAGCCACCACCCTTGCCACTTGAAAGCTATATCCACAATATTCTTTATGAAGTACCCCTT CCACCTCCAGGGAGGTCACTGAAATTTTATGGTGTTTATGAACCTGTCATCTGCCAGAGGCCTGGGCCCAGTGAACTCCCCCTCTCTGAT TACCCCCTTCGGGAGGCATTTGAGCTCCTGGGATTAGAGAACCTGGTGCAGGTGTTTACCTGTGTTCTTTTAGAGATGCAAATCCTTCTC TACTCACAAGATTATCAACGCCTGATGACTGTGGCAGAAGGCATCACCACACTTTTGTTCCCATTTCAATGGCAACATGTTTATGTGCCC ATTCTACCTGCTTCTCTGCTACATTTTCTTGATGCTCCTGTCCCTTATCTGATGGGCCTTCAGTCAAAAGAAGGAACTGACCGTTCTAAA CTAGAACTTCCTCAAGAGGCTAATTTGTGTTTTGTGGACATTGACAACCATTTTATTGAGTTGCCTGAAGAATTTCCACAGTTCCCCAAT AAAGTGGATTTTATCCAAGAACTCTCTGAGGTTCTTGTTCAATTTGGGATCCCTCCTGAGGGCAGCCTACATTGCAGTGAGAGTACCAGC AAACTGAAGAATATGGTTCTGAAAGACTTGGTCAATGACAAAAAGAACGGCAATGTCTGTACTAATAACATCAGCATGTATGAGTTACTG AAGGGCAATGAAACCATAGCCCGCTTGCAGGCTCTGGCCAAGCGTACTGGTGTGGCTGTGGAAAAAATGGACCTCTCTGCTTCTCTGGGT GAAAAAGACAAGGATTTAAAACTGCATTGTGAAGAGGCAGAACTAAGGGACTACCAGCTCAATGTACAGCTCCGAGAGGTCTTTGCTAAC CGTTTTACACAGATGTTTGCAGATTACGAAGCATTTGTCATTCAGACTGCCCAGGACATGGAATCCTGGCTGACCAACCGGGAACAGATG CAGAACTTTGACAAAGCTTCCTTTCTGTCTGACCAGCCTGAGCCTTACCTGCCATTTCTTTCACGCTTCATTGAAACACAGATGTTTGCC ACCTTTATTGATAATAAAATTATGTCTCAGTGGGAAGAGAAAGATCCTTTGCTTCGGGTCTTTGACACTCGGATTGATAAGATAAGGCTG TATAATGTAAGGGCACCCACCTTGCGGACATCTATATATCAGAAATGCAGCACTTTAAAAGAAGCAGCCCAATCAATTGAGCAGAGACTG ATGAAAATGGATCACACTGCAATCCACCCACATCTACTTGATATGAAAATTGGTCAAGGCAAATATGAGCAGGGGTTCTTTCCAAAGTTA CAGTCCGATGTCTTGGCAACAGGACCAACCAGTAACAATCGCTGGGTAAGTCGGAGTGCCACTGCACAGCGCAGGAAAGAACGCCTTCGC CAGCATTCTGAGCATGTTGGGCTGGACAACGACTTGAGGGAGAAATATATGCAAGAGGCACGAAGTTTAGGAAAAAACCTGAGGCAACCC AAACTGTCAGACCTCTCTCCTGCAGTTATTGCACAGACCAACTGTAAATTCGTAGAAGGCTTATTAAAAGAATGTAGAATGAAGACAAAG CGCATGTTGGTGGAGAAGATGGGACATGAAGCGGTGGAACTTGGCCATGGAGAAGCAAACATCACCGGCCTGGAGGAGAACACCTTGATC GCCAGCCTTTGTGACCTGCTGGAGAGGATATGGAGCCATGGCTTGCAGGTCAAGCAGGGGAAGTCGGCTTTGTGGTCACATTTAATTCAA TTTCAGGACAGAGAAGAGAAACAAGAGCACCTTGCAGAATCACCAGTTGCCCTCGGACCAGAAAGAAGAAAATCTGACTCAGGAGTTATG TTGCCAACGCTCAGGGTCTCTCTTATTCAGGACATGAGGCATATTCAAAACATGAGTGAGATCAAGACTGATGTTGGACGAGCTCGGGCG TGGATAAGACTGTCTCTAGAAAAGAAGCTCTTGTCCCAGCATCTTAAGCAGTTGCTTTCTAACCAACCACTCACCAAGAAGCTTTATAAG CGATATGCTTTTCTACGTTGCGAAGAAGAAAGAGAGCAGTTTCTTTACCACCTTCTTTCTCTCAATGCTGTGGACTATTTCTGCTTCACC AGTGTGTTCACCACTATCATGATTCCGTATAGGTCAGTGATCATCCCAATCAAAAAGCTGAGCAATGCAATAATCACATCAAACCCTTGG ATCTGTGTATCAGGAGAGCTGGGAGACACAGGAGTAATGCAGATTCCCAAAAACCTCCTCGAAATGACCTTTGAGTGCCAGAACTTGGGG AAGCTGACCACTGTTCAGATTGGTCACGATAACTCAGGACTGTTAGCCAAATGGCTAGTGGATTGTGTCATGGTCAGAAATGAAATCACA GGACATACATACAGATTCCCATGTGGGCGGTGGCTGGGGAAAGGCATTGATGATGGGAGCCTGGAGAGAATTCTTATTGGAGAGTTGATG ACATCAGCATCAGATGAAGATCTAGTAAAGCAGTGTCGGACTCCACCCCAGCAGAAGTCACCCACCACGGCTAGGAGATTGAGCATCACT TCACTGACAGGAAAAAACAACAAACCCAATGCTGGGCAGATACAAGAAGGAATTGGAGAAGCTGTGAACAATATTGTGAAACATTTTCAT AAACCTGAAAAAGAGAGAGGAAGCCTCACCGTGTTGCTGTGTGGAGAAAATGGCCTGGTTGCAGCCCTTGAGCAAGTTTTCCACCATGGG TTCAAATCTGCCCGCATCTTTCACAAGAATGTCTTCATCTGGGACTTCATAGAGAAAGTGGTTGCTTATTTTGAAACAACTGACCAGATT CTAGATAATGAAGATGATGTCCTTATTCAGAAATCATCCTGCAAAACCTTCTGCCACTACGTAAATGCTATTAATACTGCACCCAGGAAC ATTGGGAAGGATGGCAAATTCCAGATTTTAGTTTGCCTTGGAACAAGGGATCGCCTGCTCCCACAGTGGATTCCATTGTTAGCTGAGTGT CCTGCCATCACTCGAATGTATGAAGAGAGCGCTCTCCTGCGAGACCGCATGACTGTCAACTCCCTTATCCGAATTCTGCAGACCATTCAG GACTTCACCATAGTCCTAGAAGGATCACTCATCAAAGGAGTGGATGTGTAACCCAACTGGCTAGAAACTCTCAGTCCAAACCTTGCTCCT TCCCCAACTAGGGGACCGATTTGGACTTGTCTGACAGTAGTGAGTCACTGCAGGGGCAGCCAAACATATGCCCCATTTGGAACAATCCTC >23438_23438_4_DNAJB9-DENND5B_DNAJB9_chr7_108212387_ENST00000249356_DENND5B_chr12_31648853_ENST00000536562_length(amino acids)=1304AA_BP=72 MATPQSIFIFAICILMITELILASKSYYDILGVPKSASERQIKKAFHKLAMKYHPDKNKSPDAEAKFREIAEGENFDQSPLRRTFKSKVL AHYPQNIEWNPFDQDAVNMLCMPKGLSFRTQTDNKDPQFHSFIITREDGSRTYGFVLTFYEEVTSKQICTAMQTLYQMHNAEHYSSVYAS SSCSMDSLASSLDEGDTTSLLKLQRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYIHNILYEVPLPP PGRSLKFYGVYEPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPIL PASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQELSEVLVQFGIPPEGSLHCSESTSKL KNMVLKDLVNDKKNGNVCTNNISMYELLKGNETIARLQALAKRTGVAVEKMDLSASLGEKDKDLKLHCEEAELRDYQLNVQLREVFANRF TQMFADYEAFVIQTAQDMESWLTNREQMQNFDKASFLSDQPEPYLPFLSRFIETQMFATFIDNKIMSQWEEKDPLLRVFDTRIDKIRLYN VRAPTLRTSIYQKCSTLKEAAQSIEQRLMKMDHTAIHPHLLDMKIGQGKYEQGFFPKLQSDVLATGPTSNNRWVSRSATAQRRKERLRQH SEHVGLDNDLREKYMQEARSLGKNLRQPKLSDLSPAVIAQTNCKFVEGLLKECRMKTKRMLVEKMGHEAVELGHGEANITGLEENTLIAS LCDLLERIWSHGLQVKQGKSALWSHLIQFQDREEKQEHLAESPVALGPERRKSDSGVMLPTLRVSLIQDMRHIQNMSEIKTDVGRARAWI RLSLEKKLLSQHLKQLLSNQPLTKKLYKRYAFLRCEEEREQFLYHLLSLNAVDYFCFTSVFTTIMIPYRSVIIPIKKLSNAIITSNPWIC VSGELGDTGVMQIPKNLLEMTFECQNLGKLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLERILIGELMTS ASDEDLVKQCRTPPQQKSPTTARRLSITSLTGKNNKPNAGQIQEGIGEAVNNIVKHFHKPEKERGSLTVLLCGENGLVAALEQVFHHGFK SARIFHKNVFIWDFIEKVVAYFETTDQILDNEDDVLIQKSSCKTFCHYVNAINTAPRNIGKDGKFQILVCLGTRDRLLPQWIPLLAECPA -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for DNAJB9-DENND5B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for DNAJB9-DENND5B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for DNAJB9-DENND5B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies