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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DNAJC19-ADK (FusionGDB2 ID:23478)

Fusion Gene Summary for DNAJC19-ADK

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAJC19-ADK
Fusion gene ID: 23478
HgeneTgene
Gene symbol

DNAJC19

ADK

Gene ID

131118

132

Gene nameDnaJ heat shock protein family (Hsp40) member C19adenosine kinase
SynonymsPAM18|TIM14|TIMM14AK
Cytomap

3q26.33

10q22.2|10q11-q24

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial import inner membrane translocase subunit TIM14DnaJ (Hsp40) homolog, subfamily C, member 19DnaJ-like protein subfamily C member 19homolog of yeast TIM14adenosine kinaseadenosine 5'-phosphotransferasetesticular tissue protein Li 14
Modification date2020031320200313
UniProtAcc

Q96DA6

P55263

Ensembl transtripts involved in fusion geneENST00000382564, ENST00000479269, 
ENST00000486355, ENST00000491873, 
ENST00000286621, ENST00000372734, 
ENST00000467840, ENST00000539909, 
ENST00000541550, 
Fusion gene scores* DoF score2 X 3 X 2=1230 X 17 X 14=7140
# samples 364
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(64/7140*10)=-3.4797802640291
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNAJC19 [Title/Abstract] AND ADK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNAJC19(180705811)-ADK(76285014), # samples:2
DNAJC19(180705810)-ADK(76285013), # samples:2
DNAJC19(180705810)-ADK(76349039), # samples:2
Anticipated loss of major functional domain due to fusion event.DNAJC19-ADK seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
DNAJC19-ADK seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DNAJC19-ADK seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
DNAJC19-ADK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DNAJC19 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-7103-01ADNAJC19chr3

180705811

-ADKchr10

76285014

+
ChimerDB4HNSCTCGA-CV-7103DNAJC19chr3

180705810

-ADKchr10

76285013

+
ChimerDB4HNSCTCGA-CV-7103DNAJC19chr3

180705810

-ADKchr10

76349039

+


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Fusion Gene ORF analysis for DNAJC19-ADK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000382564ENST00000286621DNAJC19chr3

180705811

-ADKchr10

76285014

+
5CDS-intronENST00000382564ENST00000286621DNAJC19chr3

180705810

-ADKchr10

76285013

+
5CDS-intronENST00000382564ENST00000372734DNAJC19chr3

180705811

-ADKchr10

76285014

+
5CDS-intronENST00000382564ENST00000372734DNAJC19chr3

180705810

-ADKchr10

76285013

+
5CDS-intronENST00000382564ENST00000467840DNAJC19chr3

180705811

-ADKchr10

76285014

+
5CDS-intronENST00000382564ENST00000467840DNAJC19chr3

180705810

-ADKchr10

76285013

+
5CDS-intronENST00000382564ENST00000467840DNAJC19chr3

180705810

-ADKchr10

76349039

+
5CDS-intronENST00000382564ENST00000539909DNAJC19chr3

180705811

-ADKchr10

76285014

+
5CDS-intronENST00000382564ENST00000539909DNAJC19chr3

180705810

-ADKchr10

76285013

+
5CDS-intronENST00000382564ENST00000541550DNAJC19chr3

180705811

-ADKchr10

76285014

+
5CDS-intronENST00000382564ENST00000541550DNAJC19chr3

180705810

-ADKchr10

76285013

+
5CDS-intronENST00000479269ENST00000286621DNAJC19chr3

180705811

-ADKchr10

76285014

+
5CDS-intronENST00000479269ENST00000286621DNAJC19chr3

180705810

-ADKchr10

76285013

+
5CDS-intronENST00000479269ENST00000372734DNAJC19chr3

180705811

-ADKchr10

76285014

+
5CDS-intronENST00000479269ENST00000372734DNAJC19chr3

180705810

-ADKchr10

76285013

+
5CDS-intronENST00000479269ENST00000467840DNAJC19chr3

180705811

-ADKchr10

76285014

+
5CDS-intronENST00000479269ENST00000467840DNAJC19chr3

180705810

-ADKchr10

76285013

+
5CDS-intronENST00000479269ENST00000467840DNAJC19chr3

180705810

-ADKchr10

76349039

+
5CDS-intronENST00000479269ENST00000539909DNAJC19chr3

180705811

-ADKchr10

76285014

+
5CDS-intronENST00000479269ENST00000539909DNAJC19chr3

180705810

-ADKchr10

76285013

+
5CDS-intronENST00000479269ENST00000541550DNAJC19chr3

180705811

-ADKchr10

76285014

+
5CDS-intronENST00000479269ENST00000541550DNAJC19chr3

180705810

-ADKchr10

76285013

+
5CDS-intronENST00000486355ENST00000286621DNAJC19chr3

180705811

-ADKchr10

76285014

+
5CDS-intronENST00000486355ENST00000286621DNAJC19chr3

180705810

-ADKchr10

76285013

+
5CDS-intronENST00000486355ENST00000372734DNAJC19chr3

180705811

-ADKchr10

76285014

+
5CDS-intronENST00000486355ENST00000372734DNAJC19chr3

180705810

-ADKchr10

76285013

+
5CDS-intronENST00000486355ENST00000467840DNAJC19chr3

180705811

-ADKchr10

76285014

+
5CDS-intronENST00000486355ENST00000467840DNAJC19chr3

180705810

-ADKchr10

76285013

+
5CDS-intronENST00000486355ENST00000467840DNAJC19chr3

180705810

-ADKchr10

76349039

+
5CDS-intronENST00000486355ENST00000539909DNAJC19chr3

180705811

-ADKchr10

76285014

+
5CDS-intronENST00000486355ENST00000539909DNAJC19chr3

180705810

-ADKchr10

76285013

+
5CDS-intronENST00000486355ENST00000541550DNAJC19chr3

180705811

-ADKchr10

76285014

+
5CDS-intronENST00000486355ENST00000541550DNAJC19chr3

180705810

-ADKchr10

76285013

+
5CDS-intronENST00000491873ENST00000286621DNAJC19chr3

180705811

-ADKchr10

76285014

+
5CDS-intronENST00000491873ENST00000286621DNAJC19chr3

180705810

-ADKchr10

76285013

+
5CDS-intronENST00000491873ENST00000372734DNAJC19chr3

180705811

-ADKchr10

76285014

+
5CDS-intronENST00000491873ENST00000372734DNAJC19chr3

180705810

-ADKchr10

76285013

+
5CDS-intronENST00000491873ENST00000467840DNAJC19chr3

180705811

-ADKchr10

76285014

+
5CDS-intronENST00000491873ENST00000467840DNAJC19chr3

180705810

-ADKchr10

76285013

+
5CDS-intronENST00000491873ENST00000467840DNAJC19chr3

180705810

-ADKchr10

76349039

+
5CDS-intronENST00000491873ENST00000539909DNAJC19chr3

180705811

-ADKchr10

76285014

+
5CDS-intronENST00000491873ENST00000539909DNAJC19chr3

180705810

-ADKchr10

76285013

+
5CDS-intronENST00000491873ENST00000541550DNAJC19chr3

180705811

-ADKchr10

76285014

+
5CDS-intronENST00000491873ENST00000541550DNAJC19chr3

180705810

-ADKchr10

76285013

+
Frame-shiftENST00000479269ENST00000286621DNAJC19chr3

180705810

-ADKchr10

76349039

+
Frame-shiftENST00000479269ENST00000372734DNAJC19chr3

180705810

-ADKchr10

76349039

+
Frame-shiftENST00000479269ENST00000539909DNAJC19chr3

180705810

-ADKchr10

76349039

+
Frame-shiftENST00000479269ENST00000541550DNAJC19chr3

180705810

-ADKchr10

76349039

+
Frame-shiftENST00000486355ENST00000286621DNAJC19chr3

180705810

-ADKchr10

76349039

+
Frame-shiftENST00000486355ENST00000372734DNAJC19chr3

180705810

-ADKchr10

76349039

+
Frame-shiftENST00000486355ENST00000539909DNAJC19chr3

180705810

-ADKchr10

76349039

+
Frame-shiftENST00000486355ENST00000541550DNAJC19chr3

180705810

-ADKchr10

76349039

+
In-frameENST00000382564ENST00000286621DNAJC19chr3

180705810

-ADKchr10

76349039

+
In-frameENST00000382564ENST00000372734DNAJC19chr3

180705810

-ADKchr10

76349039

+
In-frameENST00000382564ENST00000539909DNAJC19chr3

180705810

-ADKchr10

76349039

+
In-frameENST00000382564ENST00000541550DNAJC19chr3

180705810

-ADKchr10

76349039

+
In-frameENST00000491873ENST00000286621DNAJC19chr3

180705810

-ADKchr10

76349039

+
In-frameENST00000491873ENST00000372734DNAJC19chr3

180705810

-ADKchr10

76349039

+
In-frameENST00000491873ENST00000539909DNAJC19chr3

180705810

-ADKchr10

76349039

+
In-frameENST00000491873ENST00000541550DNAJC19chr3

180705810

-ADKchr10

76349039

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000382564DNAJC19chr3180705810-ENST00000539909ADKchr1076349039+91730072662196
ENST00000382564DNAJC19chr3180705810-ENST00000286621ADKchr1076349039+69330072662196
ENST00000382564DNAJC19chr3180705810-ENST00000372734ADKchr1076349039+152130072662196
ENST00000382564DNAJC19chr3180705810-ENST00000541550ADKchr1076349039+75630072662196
ENST00000491873DNAJC19chr3180705810-ENST00000539909ADKchr1076349039+802185122547141
ENST00000491873DNAJC19chr3180705810-ENST00000286621ADKchr1076349039+578185122547141
ENST00000491873DNAJC19chr3180705810-ENST00000372734ADKchr1076349039+1406185122547141
ENST00000491873DNAJC19chr3180705810-ENST00000541550ADKchr1076349039+641185122547141

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000382564ENST00000539909DNAJC19chr3180705810-ADKchr1076349039+0.0012744710.9987255
ENST00000382564ENST00000286621DNAJC19chr3180705810-ADKchr1076349039+0.0012025380.9987974
ENST00000382564ENST00000372734DNAJC19chr3180705810-ADKchr1076349039+0.0012507310.99874926
ENST00000382564ENST00000541550DNAJC19chr3180705810-ADKchr1076349039+0.0013487290.9986513
ENST00000491873ENST00000539909DNAJC19chr3180705810-ADKchr1076349039+0.0053700820.99462986
ENST00000491873ENST00000286621DNAJC19chr3180705810-ADKchr1076349039+0.0050239420.99497604
ENST00000491873ENST00000372734DNAJC19chr3180705810-ADKchr1076349039+0.0057868520.99421316
ENST00000491873ENST00000541550DNAJC19chr3180705810-ADKchr1076349039+0.0065342260.9934657

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Fusion Genomic Features for DNAJC19-ADK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DNAJC19chr3180705810-ADKchr1076349039+0.0046329890.99536705
DNAJC19chr3180705810-ADKchr1076285013+0.0045767790.99542326
DNAJC19chr3180705810-ADKchr1076285013+0.0045767790.99542326
DNAJC19chr3180705810-ADKchr1076349039+0.0046329890.99536705
DNAJC19chr3180705810-ADKchr1076285013+0.0045767790.99542326
DNAJC19chr3180705810-ADKchr1076285013+0.0045767790.99542326

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DNAJC19-ADK


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:180705811/chr10:76285014)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAJC19

Q96DA6

ADK

P55263

FUNCTION: Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling (By similarity). May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). {ECO:0000250|UniProtKB:Q07914, ECO:0000250|UniProtKB:Q9CQV7}.FUNCTION: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNAJC19chr3:180705810chr10:76349039ENST00000382564-362_343117.0Topological domainMitochondrial intermembrane
HgeneDNAJC19chr3:180705810chr10:76349039ENST00000479269-362_31892.0Topological domainMitochondrial intermembrane
HgeneDNAJC19chr3:180705810chr10:76349039ENST00000491873-252_31892.0Topological domainMitochondrial intermembrane
HgeneDNAJC19chr3:180705810chr10:76349039ENST00000382564-364_2443117.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNAJC19chr3:180705810chr10:76349039ENST00000382564-3662_11643117.0DomainJ
HgeneDNAJC19chr3:180705810chr10:76349039ENST00000479269-3662_1161892.0DomainJ
HgeneDNAJC19chr3:180705810chr10:76349039ENST00000491873-2562_1161892.0DomainJ
HgeneDNAJC19chr3:180705810chr10:76349039ENST00000382564-3625_11643117.0Topological domainMitochondrial matrix
HgeneDNAJC19chr3:180705810chr10:76349039ENST00000479269-3625_1161892.0Topological domainMitochondrial matrix
HgeneDNAJC19chr3:180705810chr10:76349039ENST00000491873-2525_1161892.0Topological domainMitochondrial matrix
HgeneDNAJC19chr3:180705810chr10:76349039ENST00000479269-364_241892.0TransmembraneHelical
HgeneDNAJC19chr3:180705810chr10:76349039ENST00000491873-254_241892.0TransmembraneHelical
TgeneADKchr3:180705810chr10:76349039ENST000002866216118_16242363.0MotifNuclear localization signal
TgeneADKchr3:180705810chr10:76349039ENST000003727346118_16225346.0MotifNuclear localization signal
TgeneADKchr3:180705810chr10:76349039ENST000005399095108_16185306.0MotifNuclear localization signal
TgeneADKchr3:180705810chr10:76349039ENST000005415505108_16207328.0MotifNuclear localization signal


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Fusion Gene Sequence for DNAJC19-ADK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>23478_23478_1_DNAJC19-ADK_DNAJC19_chr3_180705810_ENST00000382564_ADK_chr10_76349039_ENST00000286621_length(transcript)=693nt_BP=300nt
CGACAGTTTTCCGGCCTAGTTTGCGGCTGCTCCTGCCGTGTTGCGTAGGGCGCCTGTGCTTGAGGTTGGGGGTTGCGTCGCTCTCTGGTA
AAGGCGTGCAGGTGTTGGCCGCGGCCTCTGAGCTGGGATGAGCCGTGCTCCCGGTGGAAGCAAGGGAGCCCAGCCGGAGCCATGGCCAGT
ACAGTGGTAGCAGTTGGACTGACCATTGCTGCTGCAGGATTTGCAGGCCGTTACGTTTTGCAAGCCATGAAGCATATGGAGCCTCAAGTA
AAACAAGTTTTTCAAAGCCTACCAAAATCTGAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAGATAGCC
AAAAAGACACAAGCCCTGCCAAAGATGAACTCAAAGAGGCAGCGAATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACA
GAAAGTGAAGTCACTGCTTTTGCTGTCTTGGATCAAGACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGATGCATTTGTTGGAGGT
TTTCTGTCTCAACTGGTCTCTGACAAGCCTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGC

>23478_23478_1_DNAJC19-ADK_DNAJC19_chr3_180705810_ENST00000382564_ADK_chr10_76349039_ENST00000286621_length(amino acids)=196AA_BP=76
MRRSLVKACRCWPRPLSWDEPCSRWKQGSPAGAMASTVVAVGLTIAAAGFAGRYVLQAMKHMEPQVKQVFQSLPKSEAATFAREQGFETK
DIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASI

--------------------------------------------------------------
>23478_23478_2_DNAJC19-ADK_DNAJC19_chr3_180705810_ENST00000382564_ADK_chr10_76349039_ENST00000372734_length(transcript)=1521nt_BP=300nt
CGACAGTTTTCCGGCCTAGTTTGCGGCTGCTCCTGCCGTGTTGCGTAGGGCGCCTGTGCTTGAGGTTGGGGGTTGCGTCGCTCTCTGGTA
AAGGCGTGCAGGTGTTGGCCGCGGCCTCTGAGCTGGGATGAGCCGTGCTCCCGGTGGAAGCAAGGGAGCCCAGCCGGAGCCATGGCCAGT
ACAGTGGTAGCAGTTGGACTGACCATTGCTGCTGCAGGATTTGCAGGCCGTTACGTTTTGCAAGCCATGAAGCATATGGAGCCTCAAGTA
AAACAAGTTTTTCAAAGCCTACCAAAATCTGAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAGATAGCC
AAAAAGACACAAGCCCTGCCAAAGATGAACTCAAAGAGGCAGCGAATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACA
GAAAGTGAAGTCACTGCTTTTGCTGTCTTGGATCAAGACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGATGCATTTGTTGGAGGT
TTTCTGTCTCAACTGGTCTCTGACAAGCCTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGC
TGCACCTTTCCTGAGAAGCCAGACTTCCACTGATGGAAGAGCTGAAAACACAAGCCCAGGAGTGCAGACACTGCCCTAATTGCTTCCTGA
GAATTCCCATATTAATAAAGAAGAAAATTATCTGCCATTTTTTCCTACTATAATAATGCTGAATCTTAATTTAGAGGGTACAAGGGTATG
GTAATGCTTGTAGAATCTTTATTATCTCAACAATCTAAAAAATGATGTTTATTTCCATAGTTTGATAGTGCCACTTAAATGCCAATTAAA
CAAGAATATAACATTTCAATAGAAATTTTTATTTCATTTTCAATTACTTTGTAAATTCGTGTGTATTTAGTACACTGATTTGTTTTTTTA
CATTTCTGCTTTGAATGCAGATGCAATTTAATATAATAGATTTTTTAATGAATTAATCTTAACATAGTAATCTTTAGCTTTTTATACAAA
TATATTTAATTTAGGAGTATATGTGTGTCTATACACACACATACATAAATATACCACATATACACCTGATAGTCAAATAAGGTACAGAAA
TTTTATCTTGTCAATTATGCCAAATAATCTCTTTAATGTGCACTCAAACATGTAATAAACTTTGGATAATTAAATAATGTGCCAAATTTA
AGTTGTACCACAATATTCAAATCATAGTCTTATGGAACTCTGTAATTGGACACAAACAAAAACTTGTCATATAGGAATTTTTTTCTGTCT
TTTCCCTGTGTACAGCAAACTGAGGAAGAAAGATCATTATTTAATACTGGGCCCTGAAATGACACCCAATTTGTTAATGGAATTATGAAG

>23478_23478_2_DNAJC19-ADK_DNAJC19_chr3_180705810_ENST00000382564_ADK_chr10_76349039_ENST00000372734_length(amino acids)=196AA_BP=76
MRRSLVKACRCWPRPLSWDEPCSRWKQGSPAGAMASTVVAVGLTIAAAGFAGRYVLQAMKHMEPQVKQVFQSLPKSEAATFAREQGFETK
DIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASI

--------------------------------------------------------------
>23478_23478_3_DNAJC19-ADK_DNAJC19_chr3_180705810_ENST00000382564_ADK_chr10_76349039_ENST00000539909_length(transcript)=917nt_BP=300nt
CGACAGTTTTCCGGCCTAGTTTGCGGCTGCTCCTGCCGTGTTGCGTAGGGCGCCTGTGCTTGAGGTTGGGGGTTGCGTCGCTCTCTGGTA
AAGGCGTGCAGGTGTTGGCCGCGGCCTCTGAGCTGGGATGAGCCGTGCTCCCGGTGGAAGCAAGGGAGCCCAGCCGGAGCCATGGCCAGT
ACAGTGGTAGCAGTTGGACTGACCATTGCTGCTGCAGGATTTGCAGGCCGTTACGTTTTGCAAGCCATGAAGCATATGGAGCCTCAAGTA
AAACAAGTTTTTCAAAGCCTACCAAAATCTGAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAGATAGCC
AAAAAGACACAAGCCCTGCCAAAGATGAACTCAAAGAGGCAGCGAATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACA
GAAAGTGAAGTCACTGCTTTTGCTGTCTTGGATCAAGACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGATGCATTTGTTGGAGGT
TTTCTGTCTCAACTGGTCTCTGACAAGCCTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGC
TGCACCTTTCCTGAGAAGCCAGACTTCCACTGATGGAAGAGCTGAAAACACAAGCCCAGGAGTGCAGACACTGCCCTAATTGCTTCCTGA
GAATTCCCATATTAATAAAGAAGAAAATTATCTGCCATTTTTTCCTACTATAATAATGCTGAATCTTAATTTAGAGGGTACAAGGGTATG
GTAATGCTTGTAGAATCTTTATTATCTCAACAATCTAAAAAATGATGTTTATTTCCATAGTTTGATAGTGCCACTTAAATGCCAATTAAA

>23478_23478_3_DNAJC19-ADK_DNAJC19_chr3_180705810_ENST00000382564_ADK_chr10_76349039_ENST00000539909_length(amino acids)=196AA_BP=76
MRRSLVKACRCWPRPLSWDEPCSRWKQGSPAGAMASTVVAVGLTIAAAGFAGRYVLQAMKHMEPQVKQVFQSLPKSEAATFAREQGFETK
DIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASI

--------------------------------------------------------------
>23478_23478_4_DNAJC19-ADK_DNAJC19_chr3_180705810_ENST00000382564_ADK_chr10_76349039_ENST00000541550_length(transcript)=756nt_BP=300nt
CGACAGTTTTCCGGCCTAGTTTGCGGCTGCTCCTGCCGTGTTGCGTAGGGCGCCTGTGCTTGAGGTTGGGGGTTGCGTCGCTCTCTGGTA
AAGGCGTGCAGGTGTTGGCCGCGGCCTCTGAGCTGGGATGAGCCGTGCTCCCGGTGGAAGCAAGGGAGCCCAGCCGGAGCCATGGCCAGT
ACAGTGGTAGCAGTTGGACTGACCATTGCTGCTGCAGGATTTGCAGGCCGTTACGTTTTGCAAGCCATGAAGCATATGGAGCCTCAAGTA
AAACAAGTTTTTCAAAGCCTACCAAAATCTGAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAGATAGCC
AAAAAGACACAAGCCCTGCCAAAGATGAACTCAAAGAGGCAGCGAATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACA
GAAAGTGAAGTCACTGCTTTTGCTGTCTTGGATCAAGACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGATGCATTTGTTGGAGGT
TTTCTGTCTCAACTGGTCTCTGACAAGCCTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGC
TGCACCTTTCCTGAGAAGCCAGACTTCCACTGATGGAAGAGCTGAAAACACAAGCCCAGGAGTGCAGACACTGCCCTAATTGCTTCCTGA

>23478_23478_4_DNAJC19-ADK_DNAJC19_chr3_180705810_ENST00000382564_ADK_chr10_76349039_ENST00000541550_length(amino acids)=196AA_BP=76
MRRSLVKACRCWPRPLSWDEPCSRWKQGSPAGAMASTVVAVGLTIAAAGFAGRYVLQAMKHMEPQVKQVFQSLPKSEAATFAREQGFETK
DIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASI

--------------------------------------------------------------
>23478_23478_5_DNAJC19-ADK_DNAJC19_chr3_180705810_ENST00000491873_ADK_chr10_76349039_ENST00000286621_length(transcript)=578nt_BP=185nt
GGTTGGGGGTTGCGTCGCTCTCTGGTAAAGGCGTGCAGGTGTTGGCCGCGGCCTCTGAGCTGGGATGAGCCGTGCTCCCGGTGGAAGCAA
GGGAGCCCAGCCGGAGCCATGGCCGTTACGTTTTGCAAGCCATGAAGCATATGGAGCCTCAAGTAAAACAAGTTTTTCAAAGCCTACCAA
AATCTGAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAGATAGCCAAAAAGACACAAGCCCTGCCAAAGA
TGAACTCAAAGAGGCAGCGAATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTGAAGTCACTGCTTTTGCTG
TCTTGGATCAAGACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGATGCATTTGTTGGAGGTTTTCTGTCTCAACTGGTCTCTGACA
AGCCTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAGAAGCCAGACT

>23478_23478_5_DNAJC19-ADK_DNAJC19_chr3_180705810_ENST00000491873_ADK_chr10_76349039_ENST00000286621_length(amino acids)=141AA_BP=21
MQAMKHMEPQVKQVFQSLPKSEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIID

--------------------------------------------------------------
>23478_23478_6_DNAJC19-ADK_DNAJC19_chr3_180705810_ENST00000491873_ADK_chr10_76349039_ENST00000372734_length(transcript)=1406nt_BP=185nt
GGTTGGGGGTTGCGTCGCTCTCTGGTAAAGGCGTGCAGGTGTTGGCCGCGGCCTCTGAGCTGGGATGAGCCGTGCTCCCGGTGGAAGCAA
GGGAGCCCAGCCGGAGCCATGGCCGTTACGTTTTGCAAGCCATGAAGCATATGGAGCCTCAAGTAAAACAAGTTTTTCAAAGCCTACCAA
AATCTGAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAGATAGCCAAAAAGACACAAGCCCTGCCAAAGA
TGAACTCAAAGAGGCAGCGAATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTGAAGTCACTGCTTTTGCTG
TCTTGGATCAAGACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGATGCATTTGTTGGAGGTTTTCTGTCTCAACTGGTCTCTGACA
AGCCTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAGAAGCCAGACT
TCCACTGATGGAAGAGCTGAAAACACAAGCCCAGGAGTGCAGACACTGCCCTAATTGCTTCCTGAGAATTCCCATATTAATAAAGAAGAA
AATTATCTGCCATTTTTTCCTACTATAATAATGCTGAATCTTAATTTAGAGGGTACAAGGGTATGGTAATGCTTGTAGAATCTTTATTAT
CTCAACAATCTAAAAAATGATGTTTATTTCCATAGTTTGATAGTGCCACTTAAATGCCAATTAAACAAGAATATAACATTTCAATAGAAA
TTTTTATTTCATTTTCAATTACTTTGTAAATTCGTGTGTATTTAGTACACTGATTTGTTTTTTTACATTTCTGCTTTGAATGCAGATGCA
ATTTAATATAATAGATTTTTTAATGAATTAATCTTAACATAGTAATCTTTAGCTTTTTATACAAATATATTTAATTTAGGAGTATATGTG
TGTCTATACACACACATACATAAATATACCACATATACACCTGATAGTCAAATAAGGTACAGAAATTTTATCTTGTCAATTATGCCAAAT
AATCTCTTTAATGTGCACTCAAACATGTAATAAACTTTGGATAATTAAATAATGTGCCAAATTTAAGTTGTACCACAATATTCAAATCAT
AGTCTTATGGAACTCTGTAATTGGACACAAACAAAAACTTGTCATATAGGAATTTTTTTCTGTCTTTTCCCTGTGTACAGCAAACTGAGG
AAGAAAGATCATTATTTAATACTGGGCCCTGAAATGACACCCAATTTGTTAATGGAATTATGAAGAACAGCAATATAATACACTGAAGAA

>23478_23478_6_DNAJC19-ADK_DNAJC19_chr3_180705810_ENST00000491873_ADK_chr10_76349039_ENST00000372734_length(amino acids)=141AA_BP=21
MQAMKHMEPQVKQVFQSLPKSEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIID

--------------------------------------------------------------
>23478_23478_7_DNAJC19-ADK_DNAJC19_chr3_180705810_ENST00000491873_ADK_chr10_76349039_ENST00000539909_length(transcript)=802nt_BP=185nt
GGTTGGGGGTTGCGTCGCTCTCTGGTAAAGGCGTGCAGGTGTTGGCCGCGGCCTCTGAGCTGGGATGAGCCGTGCTCCCGGTGGAAGCAA
GGGAGCCCAGCCGGAGCCATGGCCGTTACGTTTTGCAAGCCATGAAGCATATGGAGCCTCAAGTAAAACAAGTTTTTCAAAGCCTACCAA
AATCTGAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAGATAGCCAAAAAGACACAAGCCCTGCCAAAGA
TGAACTCAAAGAGGCAGCGAATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTGAAGTCACTGCTTTTGCTG
TCTTGGATCAAGACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGATGCATTTGTTGGAGGTTTTCTGTCTCAACTGGTCTCTGACA
AGCCTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAGAAGCCAGACT
TCCACTGATGGAAGAGCTGAAAACACAAGCCCAGGAGTGCAGACACTGCCCTAATTGCTTCCTGAGAATTCCCATATTAATAAAGAAGAA
AATTATCTGCCATTTTTTCCTACTATAATAATGCTGAATCTTAATTTAGAGGGTACAAGGGTATGGTAATGCTTGTAGAATCTTTATTAT

>23478_23478_7_DNAJC19-ADK_DNAJC19_chr3_180705810_ENST00000491873_ADK_chr10_76349039_ENST00000539909_length(amino acids)=141AA_BP=21
MQAMKHMEPQVKQVFQSLPKSEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIID

--------------------------------------------------------------
>23478_23478_8_DNAJC19-ADK_DNAJC19_chr3_180705810_ENST00000491873_ADK_chr10_76349039_ENST00000541550_length(transcript)=641nt_BP=185nt
GGTTGGGGGTTGCGTCGCTCTCTGGTAAAGGCGTGCAGGTGTTGGCCGCGGCCTCTGAGCTGGGATGAGCCGTGCTCCCGGTGGAAGCAA
GGGAGCCCAGCCGGAGCCATGGCCGTTACGTTTTGCAAGCCATGAAGCATATGGAGCCTCAAGTAAAACAAGTTTTTCAAAGCCTACCAA
AATCTGAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAGATAGCCAAAAAGACACAAGCCCTGCCAAAGA
TGAACTCAAAGAGGCAGCGAATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTGAAGTCACTGCTTTTGCTG
TCTTGGATCAAGACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGATGCATTTGTTGGAGGTTTTCTGTCTCAACTGGTCTCTGACA
AGCCTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAGAAGCCAGACT
TCCACTGATGGAAGAGCTGAAAACACAAGCCCAGGAGTGCAGACACTGCCCTAATTGCTTCCTGAGAATTCCCATATTAATAAAGAAGAA

>23478_23478_8_DNAJC19-ADK_DNAJC19_chr3_180705810_ENST00000491873_ADK_chr10_76349039_ENST00000541550_length(amino acids)=141AA_BP=21
MQAMKHMEPQVKQVFQSLPKSEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIID

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DNAJC19-ADK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DNAJC19-ADK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DNAJC19-ADK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource