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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DNAJC1-MLLT10 (FusionGDB2 ID:23491)

Fusion Gene Summary for DNAJC1-MLLT10

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAJC1-MLLT10
Fusion gene ID: 23491
HgeneTgene
Gene symbol

DNAJC1

MLLT10

Gene ID

64215

8028

Gene nameDnaJ heat shock protein family (Hsp40) member C1MLLT10 histone lysine methyltransferase DOT1L cofactor
SynonymsDNAJL1|ERdj1|HTJ1|MTJ1AF10
Cytomap

10p12.31

10p12.31

Type of geneprotein-codingprotein-coding
DescriptiondnaJ homolog subfamily C member 1DnaJ (Hsp40) homolog, subfamily C, member 1DnaJ-like proteindnaJ protein homolog MTJ1protein AF-10ALL1-fused gene from chromosome 10 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10type I AF10 proteintype III AF10 prot
Modification date2020031320200313
UniProtAcc

Q96KC8

P55197

Ensembl transtripts involved in fusion geneENST00000376980, ENST00000483085, 
ENST00000376946, 		ENST00000377091, 
ENST00000377100, ENST00000495130, 
ENST00000307729, ENST00000377059, 
ENST00000377072, ENST00000446906, 
Fusion gene scores* DoF score17 X 15 X 7=178517 X 30 X 5=2550
# samples 1830
** MAII scorelog2(18/1785*10)=-3.30985526258679
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/2550*10)=-3.08746284125034
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNAJC1 [Title/Abstract] AND MLLT10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNAJC1(22094909)-MLLT10(22002701), # samples:1
MLLT10(22002879)-DNAJC1(22193541), # samples:1
Anticipated loss of major functional domain due to fusion event.DNAJC1-MLLT10 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
DNAJC1-MLLT10 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
DNAJC1-MLLT10 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
DNAJC1-MLLT10 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNAJC1

GO:0050708

regulation of protein secretion

14668352

TgeneMLLT10

GO:0045944

positive regulation of transcription by RNA polymerase II

17868029


check buttonFusion gene breakpoints across DNAJC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MLLT10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A486-01ADNAJC1chr10

22094909

-MLLT10chr10

22002701

+


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Fusion Gene ORF analysis for DNAJC1-MLLT10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000376980ENST00000377091DNAJC1chr10

22094909

-MLLT10chr10

22002701

+
5CDS-intronENST00000376980ENST00000377100DNAJC1chr10

22094909

-MLLT10chr10

22002701

+
5CDS-intronENST00000376980ENST00000495130DNAJC1chr10

22094909

-MLLT10chr10

22002701

+
5UTR-3CDSENST00000483085ENST00000307729DNAJC1chr10

22094909

-MLLT10chr10

22002701

+
5UTR-3CDSENST00000483085ENST00000377059DNAJC1chr10

22094909

-MLLT10chr10

22002701

+
5UTR-3CDSENST00000483085ENST00000377072DNAJC1chr10

22094909

-MLLT10chr10

22002701

+
5UTR-3CDSENST00000483085ENST00000446906DNAJC1chr10

22094909

-MLLT10chr10

22002701

+
5UTR-intronENST00000483085ENST00000377091DNAJC1chr10

22094909

-MLLT10chr10

22002701

+
5UTR-intronENST00000483085ENST00000377100DNAJC1chr10

22094909

-MLLT10chr10

22002701

+
5UTR-intronENST00000483085ENST00000495130DNAJC1chr10

22094909

-MLLT10chr10

22002701

+
Frame-shiftENST00000376980ENST00000307729DNAJC1chr10

22094909

-MLLT10chr10

22002701

+
Frame-shiftENST00000376980ENST00000377059DNAJC1chr10

22094909

-MLLT10chr10

22002701

+
Frame-shiftENST00000376980ENST00000377072DNAJC1chr10

22094909

-MLLT10chr10

22002701

+
Frame-shiftENST00000376980ENST00000446906DNAJC1chr10

22094909

-MLLT10chr10

22002701

+
intron-3CDSENST00000376946ENST00000307729DNAJC1chr10

22094909

-MLLT10chr10

22002701

+
intron-3CDSENST00000376946ENST00000377059DNAJC1chr10

22094909

-MLLT10chr10

22002701

+
intron-3CDSENST00000376946ENST00000377072DNAJC1chr10

22094909

-MLLT10chr10

22002701

+
intron-3CDSENST00000376946ENST00000446906DNAJC1chr10

22094909

-MLLT10chr10

22002701

+
intron-intronENST00000376946ENST00000377091DNAJC1chr10

22094909

-MLLT10chr10

22002701

+
intron-intronENST00000376946ENST00000377100DNAJC1chr10

22094909

-MLLT10chr10

22002701

+
intron-intronENST00000376946ENST00000495130DNAJC1chr10

22094909

-MLLT10chr10

22002701

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DNAJC1-MLLT10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DNAJC1chr1022094908-MLLT10chr1022002700+1.65E-050.99998355
DNAJC1chr1022094908-MLLT10chr1022002700+1.65E-050.99998355

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DNAJC1-MLLT10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:22094909/:22002701)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAJC1

Q96KC8

MLLT10

P55197

FUNCTION: May modulate protein synthesis. {ECO:0000250}.FUNCTION: Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DNAJC1-MLLT10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DNAJC1-MLLT10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DNAJC1-MLLT10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DNAJC1-MLLT10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource