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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DNAJC3-STK24 (FusionGDB2 ID:23546)

Fusion Gene Summary for DNAJC3-STK24

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAJC3-STK24
Fusion gene ID: 23546
HgeneTgene
Gene symbol

DNAJC3

STK24

Gene ID

5611

8428

Gene nameDnaJ heat shock protein family (Hsp40) member C3serine/threonine kinase 24
SynonymsACPHD|ERdj6|HP58|P58|P58IPK|PRKRI|p58(IPK)HEL-S-95|MST3|MST3B|STE20|STK3
Cytomap

13q32.1

13q32.2

Type of geneprotein-codingprotein-coding
DescriptiondnaJ homolog subfamily C member 3DnaJ (Hsp40) homolog, subfamily C, member 3ER-resident protein ERdj6endoplasmic reticulum DNA J domain-containing protein 6interferon-induced, double-stranded RNA-activated protein kinase inhibitorprotein kinase inhibserine/threonine-protein kinase 24STE20-like kinase 3STE20-like kinase MST3epididymis secretory protein Li 95mammalian STE20-like protein kinase 3serine/threonine kinase 24 (STE20 homolog, yeast)sterile 20-like kinase 3
Modification date2020032920200313
UniProtAcc

Q13217

.
Ensembl transtripts involved in fusion geneENST00000376795, ENST00000602402, 
ENST00000376547, ENST00000481288, 
ENST00000397517, ENST00000539966, 
Fusion gene scores* DoF score15 X 14 X 8=168015 X 8 X 8=960
# samples 1818
** MAII scorelog2(18/1680*10)=-3.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/960*10)=-2.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNAJC3 [Title/Abstract] AND STK24 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNAJC3(96377506)-STK24(99118815), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSTK24

GO:0006468

protein phosphorylation

19604147

TgeneSTK24

GO:0042542

response to hydrogen peroxide

22291017

TgeneSTK24

GO:0046777

protein autophosphorylation

17046825|17657516


check buttonFusion gene breakpoints across DNAJC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across STK24 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HF-A5NBDNAJC3chr13

96377506

+STK24chr13

99118815

-


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Fusion Gene ORF analysis for DNAJC3-STK24

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000376795ENST00000376547DNAJC3chr13

96377506

+STK24chr13

99118815

-
5CDS-intronENST00000376795ENST00000481288DNAJC3chr13

96377506

+STK24chr13

99118815

-
5CDS-intronENST00000602402ENST00000376547DNAJC3chr13

96377506

+STK24chr13

99118815

-
5CDS-intronENST00000602402ENST00000481288DNAJC3chr13

96377506

+STK24chr13

99118815

-
In-frameENST00000376795ENST00000397517DNAJC3chr13

96377506

+STK24chr13

99118815

-
In-frameENST00000376795ENST00000539966DNAJC3chr13

96377506

+STK24chr13

99118815

-
In-frameENST00000602402ENST00000397517DNAJC3chr13

96377506

+STK24chr13

99118815

-
In-frameENST00000602402ENST00000539966DNAJC3chr13

96377506

+STK24chr13

99118815

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000602402DNAJC3chr1396377506+ENST00000397517STK24chr1399118815-4181510451208387
ENST00000602402DNAJC3chr1396377506+ENST00000539966STK24chr1399118815-1467510451208387
ENST00000376795DNAJC3chr1396377506+ENST00000397517STK24chr1399118815-4162491261189387
ENST00000376795DNAJC3chr1396377506+ENST00000539966STK24chr1399118815-1448491261189387

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000602402ENST00000397517DNAJC3chr1396377506+STK24chr1399118815-0.0007254820.99927455
ENST00000602402ENST00000539966DNAJC3chr1396377506+STK24chr1399118815-0.0029448640.9970552
ENST00000376795ENST00000397517DNAJC3chr1396377506+STK24chr1399118815-0.0007000890.9992999
ENST00000376795ENST00000539966DNAJC3chr1396377506+STK24chr1399118815-0.0026209550.99737906

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Fusion Genomic Features for DNAJC3-STK24


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DNAJC3-STK24


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:96377506/chr13:99118815)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAJC3

Q13217

.
FUNCTION: Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. {ECO:0000250|UniProtKB:Q27968, ECO:0000250|UniProtKB:Q91YW3, ECO:0000269|PubMed:12601012, ECO:0000269|PubMed:8576172, ECO:0000269|PubMed:9447982, ECO:0000269|PubMed:9920933}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNAJC3chr13:96377506chr13:99118815ENST00000602402+41237_70131505.0RepeatNote=TPR 1
HgeneDNAJC3chr13:96377506chr13:99118815ENST00000602402+41272_104131505.0RepeatNote=TPR 2
TgeneSTK24chr13:96377506chr13:99118815ENST00000376547411278_292211444.0MotifNote=Bipartite nuclear localization signal
TgeneSTK24chr13:96377506chr13:99118815ENST00000376547411335_386211444.0MotifNote=Nuclear export signal (NES)
TgeneSTK24chr13:96377506chr13:99118815ENST00000397517411278_292199432.0MotifNote=Bipartite nuclear localization signal
TgeneSTK24chr13:96377506chr13:99118815ENST00000397517411335_386199432.0MotifNote=Nuclear export signal (NES)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNAJC3chr13:96377506chr13:99118815ENST00000602402+412394_462131505.0DomainJ
HgeneDNAJC3chr13:96377506chr13:99118815ENST00000602402+412375_393131505.0RegionNote=Flexible linker
HgeneDNAJC3chr13:96377506chr13:99118815ENST00000602402+412105_138131505.0RepeatNote=TPR 3
HgeneDNAJC3chr13:96377506chr13:99118815ENST00000602402+412154_187131505.0RepeatNote=TPR 4
HgeneDNAJC3chr13:96377506chr13:99118815ENST00000602402+412189_221131505.0RepeatNote=TPR 5
HgeneDNAJC3chr13:96377506chr13:99118815ENST00000602402+412222_255131505.0RepeatNote=TPR 6
HgeneDNAJC3chr13:96377506chr13:99118815ENST00000602402+412268_301131505.0RepeatNote=TPR 7
HgeneDNAJC3chr13:96377506chr13:99118815ENST00000602402+412306_339131505.0RepeatNote=TPR 8
HgeneDNAJC3chr13:96377506chr13:99118815ENST00000602402+412340_373131505.0RepeatNote=TPR 9
TgeneSTK24chr13:96377506chr13:99118815ENST0000037654741136_286211444.0DomainProtein kinase
TgeneSTK24chr13:96377506chr13:99118815ENST0000039751741136_286199432.0DomainProtein kinase
TgeneSTK24chr13:96377506chr13:99118815ENST00000376547411112_114211444.0Nucleotide bindingNote=ATP
TgeneSTK24chr13:96377506chr13:99118815ENST0000037654741142_50211444.0Nucleotide bindingNote=ATP
TgeneSTK24chr13:96377506chr13:99118815ENST00000397517411112_114199432.0Nucleotide bindingNote=ATP
TgeneSTK24chr13:96377506chr13:99118815ENST0000039751741142_50199432.0Nucleotide bindingNote=ATP


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Fusion Gene Sequence for DNAJC3-STK24


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>23546_23546_1_DNAJC3-STK24_DNAJC3_chr13_96377506_ENST00000376795_STK24_chr13_99118815_ENST00000397517_length(transcript)=4162nt_BP=491nt
CGAGAGCCGACGGCGGGCGGGCGCAGCTGCTGCCGGAGCGCCGGCGCGTGCTGGTGGGCCACACACCTTTCCTCCTCTTCACTCGCGAGC
CCTCGGACATGGTGGCCCCCGGCTCCGTGACCAGCCGGCTGGGCTCGGTATTCCCCTTCCTGCTAGTCCTGGTGGATCTGCAGTACGAAG
GTGCTGAATGTGGAGTAAATGCAGATGTTGAGAAACATCTTGAATTGGGCAAGAAATTACTTGCAGCTGGACAGCTAGCTGATGCTTTAT
CTCAGTTTCATGCTGCCGTAGATGGTGACCCTGATAACTATATTGCTTATTATCGGAGGGCTACTGTCTTTTTAGCTATGGGCAAATCAA
AAGCTGCACTTCCTGATTTAACTAAAGTGATTCAATTGAAGATGGACTTCACTGCAGCAAGATTACAGAGAGGTCACTTATTACTCAAAC
AAGGAAAACTTGATGAAGCAGAAGATGATTTTAAAAAAGTGGCAGACATCTGGTCCCTGGGCATAACAGCTATTGAACTTGCAAGAGGGG
AACCACCTCATTCCGAGCTGCACCCCATGAAAGTTTTATTCCTCATTCCAAAGAACAACCCACCGACGTTGGAAGGAAACTACAGTAAAC
CCCTCAAGGAGTTTGTGGAGGCCTGTTTGAATAAGGAGCCGAGCTTTAGACCCACTGCTAAGGAGTTATTGAAGCACAAGTTTATACTAC
GCAATGCAAAGAAAACTTCCTACTTGACCGAGCTCATCGACAGGTACAAGAGATGGAAGGCCGAGCAGAGCCATGACGACTCGAGCTCCG
AGGATTCCGACGCGGAAACAGATGGCCAAGCCTCGGGGGGCAGTGATTCTGGGGACTGGATCTTCACAATCCGAGAAAAAGATCCCAAGA
ATCTCGAGAATGGAGCTCTTCAGCCATCGGACTTGGACAGAAATAAGATGAAAGACATCCCGAAGAGGCCTTTCTCTCAGTGTTTATCTA
CAATTATTTCTCCTCTGTTTGCAGAGTTGAAGGAGAAGAGCCAGGCGTGCGGAGGGAACTTGGGGTCCATTGAAGAGCTGCGAGGGGCCA
TCTACCTAGCGGAGGAGGCGTGCCCTGGCATCTCCGACACCATGGTGGCCCAGCTCGTGCAGCGGCTCCAGAGATACTCTCTAAGTGGTG
GAGGAACTTCATCCCACTGAAATTCCTTTGGCATTTGGGGTTTTGTTTTTCCTTTTTTCCTTCTTCATCCTCCTCCTTTTTTAAAAGTCA
ACGAGAGCCTTCGCTGACTCCACCGAAGAGGTGCGCCACTGGGAGCCACCCCAGCGCCAGGCGCCCGTCCAGGGACACACACAGTCTTCA
CTGTGCTGCAGCCAGATGAAGTCTCTCAGATGGGTGGGGAGGGTCAGCTCCTTCCAGCGATCATTTTATTTTATTTTATTACTTTTGTTT
TTAATTTTAACCATAGTGCACATATTCCAGGAAAGTGTCTTTAAAAACAAAAACAAACCCTGAAATGTATATTTGGGATTATGATAAGGC
AACTAAAGACATGAAACCTCAGGTATCCTGCTTTAAGTTGATAACTCCCTCTGGGAGCTGGAGAATCGCTCTGGTGGATGGGTGTACAGA
TTTGTATATAATGTCATTTTTACGGAAACCCTTTCGGCGTGCATAAGGAATCACTGTGTACAAACTGGCCAAGTGCTTCTGTAGATAACG
TCAGTGGAGTAAATATTCGACAGGCCATAACTTGAGTCTATTGCCTTGCCTTTATTACATGTACATTTTGAATTCTGTGACCAGTGATTT
GGGTTTTATTTTGTATTTGCAGGGTTTGTCATTAATAATTAATGCCCCTCTCTTACAGAACACTCCTATTTGTACCTCAACAAATGCAAA
TTTTCCCCGTTTGCCCTACGCCCCTTTTGGTACACCTAGAGGTTGATTTCCTTTTTCATCGATGGTACTATTTCTTAGTGTTTTAAATTG
GAACATATCTTGCCTCATGAAGCTTTAAATTATAATTTTCAGTTTCTCCCCATGAAGCGCTCTCGTCTGACATTTGTTTGGAATCGTGCC
ACTGCTGGTCTGCGCCAGATGTACCGTCCTTTCCAATACGATTTTCTGTTGCACCTTGTAGTGGATTCTGCATATCATCTTTCCCACCTA
AAAATGTCTGAATGCTTACACAAATAAATTTTATAACACGCTTATTTTGCATACTCCTTGAAATGTGACTCTTCAGAGGACAGGGCACCT
GCTGTGTATGTGTGGCCGTGCGTGTGTACTCGTGGCTGTGTGTGTGTGATGAGACACTTTGGAAGACTCCAGGGAGAAGTCCCCAGGCCT
GGAGCTGCCGAGTGCCCAGGTCAGCGCCCTGGACTGCTTGCGCACTTGCTCACCGAGATGATGCAGTTGGAGGTTGCTGATCTGTGCGAT
TGCTGTAGCGGTTGCCGGGGACCTTAAGAGTTATTTTGCTTCTCTGGAAGGGGCCTATGCTTGCTAGGCAGGCAGCCAGTGTGTCTGTTT
TTCTTGGTTTGCTGTGGGACCTTGCTTGGCGAGGGGGAAAATCTCTGGGTTTCTGGAGTGGGAGGGTTCGTGCAGCAGCTGTTGACTGGT
ACATGAAGCATTCTTTTATGTTTGTTGAAGCTGATGATTGACATCTCCCGTGGGTGTGCCAGTTCTTGTGGAGTTAAGACAGGATTTTTG
GAAGCAAGGAAGTTAGTGGGTGAGCTTGGGGATGTAGCTCAGCTATCTGCTGGTCTAGTGGCCTCTAAGCTATAGGGAGGGGACAGAGCC
CTGAGCTACAGATGCTTGAGTGGGTTATTGTGTCGGTTTGCTAGTGCAGTCTGGTTTTTAAGCTCTAAAATTGAGGTATTTTATTAGAAG
TGGATTTGGGTTGAACTCTTAATTTGTATAAGGGATATATTTTGGTTGGGGAAATAGAACTGAGTTGCTAATTCTTATTGTACTCATTAC
TCCATACAAGAATGTTATGTTGAATAATAAAATTGGAGAAGATTTCATTTTGTGTTTCCAGGGAGTATTCTGTGTGGGGAACTGTTTCCT
TACGTGAGGCCGGCGGCATAAGTCAAAGATGAGTTTTGTCCTTGCGAATCACACAGATTGAGTCTGTGTTCCCCAGGGTGTGCCGTTACC
TGATTTTTAAGTGAGCCAGGGCGGACAGCAGCTTTTCTGATTTACAGAGTTCTTCAGATTTACAAATGGACAATGACATCACAGTTTTTA
GCACTGAAGCCAGTCTCATGCTAGTAACAGTGGGTGAGCCGCTCGAGGGACTGGGTTCTAATGAATACTGGTATGAACGGGGAGTCTCTG
CAGTCGCCAGACAAATCATACTCAGCCCCTTCCCCCGTAGAGCAACAAGTGGTTCTTTTAGAGTTGACTGGCAGCATTTCCTGTCGGGGG
AGGTGGGGTTTGATGGAGTTAGAAAGCTCGCCTCTGTGTACATTCTCTCCTGGGCTGTTACTTTCTGTAGACGCACAAAATCAGCCCCAA
TGTTTTTAAGGGCATCTTAGCCAAGGAAGCTGGCTTTTGTGTCGCCACTTCCAGGCCTGCATTAAGAGAGAGCCCAGGCACCAGGGCTAC
CACTGGAACCTGCCTCAGCGTCAACTGCTGCTGGTCTGTAGCCAGGCCCAGCCTTTGAGACGGGTTTACTGTCACCAGTAGCCTCTCAGT
GCCAGCCCTGAGCTGCTCCTGGCTCAGCTGCCCAGAGCCTGCAGCCTGGGGAGGTACTCAGCCTCTGGGAGACGAGGGCCGTGGACTGGG
TGGCTGGTAGCTCCTGCGTTTTTGAGCTGTGTCCTGGCTGGCTGCTGCCAATGAGGTGGACACCAGTGTGGTTTGGGGTGCACTGGCCAC
TTCTTGCTGGGTTCTGATTTTCTTGGAAGTGCATCTGCCTTCCTTATCCAATAGTTTTATCCCTGCATTGCTCTTGTGAAGTGGCTGGTT
TGGTTCTGTATGTAGCATTTTGTACCTTTCCTCTGGCAAAACACTGTCAGTTTATAAACATTTTTTATATTTCCCTCCTTTAAAAACAGC
TTGTGTATTTCTGCTATAAAATGTGTCAGCAAAGGCAGAGTGACCTAATAGGGCATGTTCTTAAGCACAGGGACTGTATCATGCAGGGGC

>23546_23546_1_DNAJC3-STK24_DNAJC3_chr13_96377506_ENST00000376795_STK24_chr13_99118815_ENST00000397517_length(amino acids)=387AA_BP=155
MLPERRRVLVGHTPFLLFTREPSDMVAPGSVTSRLGSVFPFLLVLVDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDG
DPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVADIWSLGITAIELARGEPPHSELHP
MKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDG
QASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACP

--------------------------------------------------------------
>23546_23546_2_DNAJC3-STK24_DNAJC3_chr13_96377506_ENST00000376795_STK24_chr13_99118815_ENST00000539966_length(transcript)=1448nt_BP=491nt
CGAGAGCCGACGGCGGGCGGGCGCAGCTGCTGCCGGAGCGCCGGCGCGTGCTGGTGGGCCACACACCTTTCCTCCTCTTCACTCGCGAGC
CCTCGGACATGGTGGCCCCCGGCTCCGTGACCAGCCGGCTGGGCTCGGTATTCCCCTTCCTGCTAGTCCTGGTGGATCTGCAGTACGAAG
GTGCTGAATGTGGAGTAAATGCAGATGTTGAGAAACATCTTGAATTGGGCAAGAAATTACTTGCAGCTGGACAGCTAGCTGATGCTTTAT
CTCAGTTTCATGCTGCCGTAGATGGTGACCCTGATAACTATATTGCTTATTATCGGAGGGCTACTGTCTTTTTAGCTATGGGCAAATCAA
AAGCTGCACTTCCTGATTTAACTAAAGTGATTCAATTGAAGATGGACTTCACTGCAGCAAGATTACAGAGAGGTCACTTATTACTCAAAC
AAGGAAAACTTGATGAAGCAGAAGATGATTTTAAAAAAGTGGCAGACATCTGGTCCCTGGGCATAACAGCTATTGAACTTGCAAGAGGGG
AACCACCTCATTCCGAGCTGCACCCCATGAAAGTTTTATTCCTCATTCCAAAGAACAACCCACCGACGTTGGAAGGAAACTACAGTAAAC
CCCTCAAGGAGTTTGTGGAGGCCTGTTTGAATAAGGAGCCGAGCTTTAGACCCACTGCTAAGGAGTTATTGAAGCACAAGTTTATACTAC
GCAATGCAAAGAAAACTTCCTACTTGACCGAGCTCATCGACAGGTACAAGAGATGGAAGGCCGAGCAGAGCCATGACGACTCGAGCTCCG
AGGATTCCGACGCGGAAACAGATGGCCAAGCCTCGGGGGGCAGTGATTCTGGGGACTGGATCTTCACAATCCGAGAAAAAGATCCCAAGA
ATCTCGAGAATGGAGCTCTTCAGCCATCGGACTTGGACAGAAATAAGATGAAAGACATCCCGAAGAGGCCTTTCTCTCAGTGTTTATCTA
CAATTATTTCTCCTCTGTTTGCAGAGTTGAAGGAGAAGAGCCAGGCGTGCGGAGGGAACTTGGGGTCCATTGAAGAGCTGCGAGGGGCCA
TCTACCTAGCGGAGGAGGCGTGCCCTGGCATCTCCGACACCATGGTGGCCCAGCTCGTGCAGCGGCTCCAGAGATACTCTCTAAGTGGTG
GAGGAACTTCATCCCACTGAAATTCCTTTGGCATTTGGGGTTTTGTTTTTCCTTTTTTCCTTCTTCATCCTCCTCCTTTTTTAAAAGTCA
ACGAGAGCCTTCGCTGACTCCACCGAAGAGGTGCGCCACTGGGAGCCACCCCAGCGCCAGGCGCCCGTCCAGGGACACACACAGTCTTCA
CTGTGCTGCAGCCAGATGAAGTCTCTCAGATGGGTGGGGAGGGTCAGCTCCTTCCAGCGATCATTTTATTTTATTTTATTACTTTTGTTT

>23546_23546_2_DNAJC3-STK24_DNAJC3_chr13_96377506_ENST00000376795_STK24_chr13_99118815_ENST00000539966_length(amino acids)=387AA_BP=155
MLPERRRVLVGHTPFLLFTREPSDMVAPGSVTSRLGSVFPFLLVLVDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDG
DPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVADIWSLGITAIELARGEPPHSELHP
MKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDG
QASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACP

--------------------------------------------------------------
>23546_23546_3_DNAJC3-STK24_DNAJC3_chr13_96377506_ENST00000602402_STK24_chr13_99118815_ENST00000397517_length(transcript)=4181nt_BP=510nt
AGAGCCACTGAGGCCTGAGCGAGAGCCGACGGCGGGCGGGCGCAGCTGCTGCCGGAGCGCCGGCGCGTGCTGGTGGGCCACACACCTTTC
CTCCTCTTCACTCGCGAGCCCTCGGACATGGTGGCCCCCGGCTCCGTGACCAGCCGGCTGGGCTCGGTATTCCCCTTCCTGCTAGTCCTG
GTGGATCTGCAGTACGAAGGTGCTGAATGTGGAGTAAATGCAGATGTTGAGAAACATCTTGAATTGGGCAAGAAATTACTTGCAGCTGGA
CAGCTAGCTGATGCTTTATCTCAGTTTCATGCTGCCGTAGATGGTGACCCTGATAACTATATTGCTTATTATCGGAGGGCTACTGTCTTT
TTAGCTATGGGCAAATCAAAAGCTGCACTTCCTGATTTAACTAAAGTGATTCAATTGAAGATGGACTTCACTGCAGCAAGATTACAGAGA
GGTCACTTATTACTCAAACAAGGAAAACTTGATGAAGCAGAAGATGATTTTAAAAAAGTGGCAGACATCTGGTCCCTGGGCATAACAGCT
ATTGAACTTGCAAGAGGGGAACCACCTCATTCCGAGCTGCACCCCATGAAAGTTTTATTCCTCATTCCAAAGAACAACCCACCGACGTTG
GAAGGAAACTACAGTAAACCCCTCAAGGAGTTTGTGGAGGCCTGTTTGAATAAGGAGCCGAGCTTTAGACCCACTGCTAAGGAGTTATTG
AAGCACAAGTTTATACTACGCAATGCAAAGAAAACTTCCTACTTGACCGAGCTCATCGACAGGTACAAGAGATGGAAGGCCGAGCAGAGC
CATGACGACTCGAGCTCCGAGGATTCCGACGCGGAAACAGATGGCCAAGCCTCGGGGGGCAGTGATTCTGGGGACTGGATCTTCACAATC
CGAGAAAAAGATCCCAAGAATCTCGAGAATGGAGCTCTTCAGCCATCGGACTTGGACAGAAATAAGATGAAAGACATCCCGAAGAGGCCT
TTCTCTCAGTGTTTATCTACAATTATTTCTCCTCTGTTTGCAGAGTTGAAGGAGAAGAGCCAGGCGTGCGGAGGGAACTTGGGGTCCATT
GAAGAGCTGCGAGGGGCCATCTACCTAGCGGAGGAGGCGTGCCCTGGCATCTCCGACACCATGGTGGCCCAGCTCGTGCAGCGGCTCCAG
AGATACTCTCTAAGTGGTGGAGGAACTTCATCCCACTGAAATTCCTTTGGCATTTGGGGTTTTGTTTTTCCTTTTTTCCTTCTTCATCCT
CCTCCTTTTTTAAAAGTCAACGAGAGCCTTCGCTGACTCCACCGAAGAGGTGCGCCACTGGGAGCCACCCCAGCGCCAGGCGCCCGTCCA
GGGACACACACAGTCTTCACTGTGCTGCAGCCAGATGAAGTCTCTCAGATGGGTGGGGAGGGTCAGCTCCTTCCAGCGATCATTTTATTT
TATTTTATTACTTTTGTTTTTAATTTTAACCATAGTGCACATATTCCAGGAAAGTGTCTTTAAAAACAAAAACAAACCCTGAAATGTATA
TTTGGGATTATGATAAGGCAACTAAAGACATGAAACCTCAGGTATCCTGCTTTAAGTTGATAACTCCCTCTGGGAGCTGGAGAATCGCTC
TGGTGGATGGGTGTACAGATTTGTATATAATGTCATTTTTACGGAAACCCTTTCGGCGTGCATAAGGAATCACTGTGTACAAACTGGCCA
AGTGCTTCTGTAGATAACGTCAGTGGAGTAAATATTCGACAGGCCATAACTTGAGTCTATTGCCTTGCCTTTATTACATGTACATTTTGA
ATTCTGTGACCAGTGATTTGGGTTTTATTTTGTATTTGCAGGGTTTGTCATTAATAATTAATGCCCCTCTCTTACAGAACACTCCTATTT
GTACCTCAACAAATGCAAATTTTCCCCGTTTGCCCTACGCCCCTTTTGGTACACCTAGAGGTTGATTTCCTTTTTCATCGATGGTACTAT
TTCTTAGTGTTTTAAATTGGAACATATCTTGCCTCATGAAGCTTTAAATTATAATTTTCAGTTTCTCCCCATGAAGCGCTCTCGTCTGAC
ATTTGTTTGGAATCGTGCCACTGCTGGTCTGCGCCAGATGTACCGTCCTTTCCAATACGATTTTCTGTTGCACCTTGTAGTGGATTCTGC
ATATCATCTTTCCCACCTAAAAATGTCTGAATGCTTACACAAATAAATTTTATAACACGCTTATTTTGCATACTCCTTGAAATGTGACTC
TTCAGAGGACAGGGCACCTGCTGTGTATGTGTGGCCGTGCGTGTGTACTCGTGGCTGTGTGTGTGTGATGAGACACTTTGGAAGACTCCA
GGGAGAAGTCCCCAGGCCTGGAGCTGCCGAGTGCCCAGGTCAGCGCCCTGGACTGCTTGCGCACTTGCTCACCGAGATGATGCAGTTGGA
GGTTGCTGATCTGTGCGATTGCTGTAGCGGTTGCCGGGGACCTTAAGAGTTATTTTGCTTCTCTGGAAGGGGCCTATGCTTGCTAGGCAG
GCAGCCAGTGTGTCTGTTTTTCTTGGTTTGCTGTGGGACCTTGCTTGGCGAGGGGGAAAATCTCTGGGTTTCTGGAGTGGGAGGGTTCGT
GCAGCAGCTGTTGACTGGTACATGAAGCATTCTTTTATGTTTGTTGAAGCTGATGATTGACATCTCCCGTGGGTGTGCCAGTTCTTGTGG
AGTTAAGACAGGATTTTTGGAAGCAAGGAAGTTAGTGGGTGAGCTTGGGGATGTAGCTCAGCTATCTGCTGGTCTAGTGGCCTCTAAGCT
ATAGGGAGGGGACAGAGCCCTGAGCTACAGATGCTTGAGTGGGTTATTGTGTCGGTTTGCTAGTGCAGTCTGGTTTTTAAGCTCTAAAAT
TGAGGTATTTTATTAGAAGTGGATTTGGGTTGAACTCTTAATTTGTATAAGGGATATATTTTGGTTGGGGAAATAGAACTGAGTTGCTAA
TTCTTATTGTACTCATTACTCCATACAAGAATGTTATGTTGAATAATAAAATTGGAGAAGATTTCATTTTGTGTTTCCAGGGAGTATTCT
GTGTGGGGAACTGTTTCCTTACGTGAGGCCGGCGGCATAAGTCAAAGATGAGTTTTGTCCTTGCGAATCACACAGATTGAGTCTGTGTTC
CCCAGGGTGTGCCGTTACCTGATTTTTAAGTGAGCCAGGGCGGACAGCAGCTTTTCTGATTTACAGAGTTCTTCAGATTTACAAATGGAC
AATGACATCACAGTTTTTAGCACTGAAGCCAGTCTCATGCTAGTAACAGTGGGTGAGCCGCTCGAGGGACTGGGTTCTAATGAATACTGG
TATGAACGGGGAGTCTCTGCAGTCGCCAGACAAATCATACTCAGCCCCTTCCCCCGTAGAGCAACAAGTGGTTCTTTTAGAGTTGACTGG
CAGCATTTCCTGTCGGGGGAGGTGGGGTTTGATGGAGTTAGAAAGCTCGCCTCTGTGTACATTCTCTCCTGGGCTGTTACTTTCTGTAGA
CGCACAAAATCAGCCCCAATGTTTTTAAGGGCATCTTAGCCAAGGAAGCTGGCTTTTGTGTCGCCACTTCCAGGCCTGCATTAAGAGAGA
GCCCAGGCACCAGGGCTACCACTGGAACCTGCCTCAGCGTCAACTGCTGCTGGTCTGTAGCCAGGCCCAGCCTTTGAGACGGGTTTACTG
TCACCAGTAGCCTCTCAGTGCCAGCCCTGAGCTGCTCCTGGCTCAGCTGCCCAGAGCCTGCAGCCTGGGGAGGTACTCAGCCTCTGGGAG
ACGAGGGCCGTGGACTGGGTGGCTGGTAGCTCCTGCGTTTTTGAGCTGTGTCCTGGCTGGCTGCTGCCAATGAGGTGGACACCAGTGTGG
TTTGGGGTGCACTGGCCACTTCTTGCTGGGTTCTGATTTTCTTGGAAGTGCATCTGCCTTCCTTATCCAATAGTTTTATCCCTGCATTGC
TCTTGTGAAGTGGCTGGTTTGGTTCTGTATGTAGCATTTTGTACCTTTCCTCTGGCAAAACACTGTCAGTTTATAAACATTTTTTATATT
TCCCTCCTTTAAAAACAGCTTGTGTATTTCTGCTATAAAATGTGTCAGCAAAGGCAGAGTGACCTAATAGGGCATGTTCTTAAGCACAGG

>23546_23546_3_DNAJC3-STK24_DNAJC3_chr13_96377506_ENST00000602402_STK24_chr13_99118815_ENST00000397517_length(amino acids)=387AA_BP=155
MLPERRRVLVGHTPFLLFTREPSDMVAPGSVTSRLGSVFPFLLVLVDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDG
DPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVADIWSLGITAIELARGEPPHSELHP
MKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDG
QASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACP

--------------------------------------------------------------
>23546_23546_4_DNAJC3-STK24_DNAJC3_chr13_96377506_ENST00000602402_STK24_chr13_99118815_ENST00000539966_length(transcript)=1467nt_BP=510nt
AGAGCCACTGAGGCCTGAGCGAGAGCCGACGGCGGGCGGGCGCAGCTGCTGCCGGAGCGCCGGCGCGTGCTGGTGGGCCACACACCTTTC
CTCCTCTTCACTCGCGAGCCCTCGGACATGGTGGCCCCCGGCTCCGTGACCAGCCGGCTGGGCTCGGTATTCCCCTTCCTGCTAGTCCTG
GTGGATCTGCAGTACGAAGGTGCTGAATGTGGAGTAAATGCAGATGTTGAGAAACATCTTGAATTGGGCAAGAAATTACTTGCAGCTGGA
CAGCTAGCTGATGCTTTATCTCAGTTTCATGCTGCCGTAGATGGTGACCCTGATAACTATATTGCTTATTATCGGAGGGCTACTGTCTTT
TTAGCTATGGGCAAATCAAAAGCTGCACTTCCTGATTTAACTAAAGTGATTCAATTGAAGATGGACTTCACTGCAGCAAGATTACAGAGA
GGTCACTTATTACTCAAACAAGGAAAACTTGATGAAGCAGAAGATGATTTTAAAAAAGTGGCAGACATCTGGTCCCTGGGCATAACAGCT
ATTGAACTTGCAAGAGGGGAACCACCTCATTCCGAGCTGCACCCCATGAAAGTTTTATTCCTCATTCCAAAGAACAACCCACCGACGTTG
GAAGGAAACTACAGTAAACCCCTCAAGGAGTTTGTGGAGGCCTGTTTGAATAAGGAGCCGAGCTTTAGACCCACTGCTAAGGAGTTATTG
AAGCACAAGTTTATACTACGCAATGCAAAGAAAACTTCCTACTTGACCGAGCTCATCGACAGGTACAAGAGATGGAAGGCCGAGCAGAGC
CATGACGACTCGAGCTCCGAGGATTCCGACGCGGAAACAGATGGCCAAGCCTCGGGGGGCAGTGATTCTGGGGACTGGATCTTCACAATC
CGAGAAAAAGATCCCAAGAATCTCGAGAATGGAGCTCTTCAGCCATCGGACTTGGACAGAAATAAGATGAAAGACATCCCGAAGAGGCCT
TTCTCTCAGTGTTTATCTACAATTATTTCTCCTCTGTTTGCAGAGTTGAAGGAGAAGAGCCAGGCGTGCGGAGGGAACTTGGGGTCCATT
GAAGAGCTGCGAGGGGCCATCTACCTAGCGGAGGAGGCGTGCCCTGGCATCTCCGACACCATGGTGGCCCAGCTCGTGCAGCGGCTCCAG
AGATACTCTCTAAGTGGTGGAGGAACTTCATCCCACTGAAATTCCTTTGGCATTTGGGGTTTTGTTTTTCCTTTTTTCCTTCTTCATCCT
CCTCCTTTTTTAAAAGTCAACGAGAGCCTTCGCTGACTCCACCGAAGAGGTGCGCCACTGGGAGCCACCCCAGCGCCAGGCGCCCGTCCA
GGGACACACACAGTCTTCACTGTGCTGCAGCCAGATGAAGTCTCTCAGATGGGTGGGGAGGGTCAGCTCCTTCCAGCGATCATTTTATTT

>23546_23546_4_DNAJC3-STK24_DNAJC3_chr13_96377506_ENST00000602402_STK24_chr13_99118815_ENST00000539966_length(amino acids)=387AA_BP=155
MLPERRRVLVGHTPFLLFTREPSDMVAPGSVTSRLGSVFPFLLVLVDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDG
DPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVADIWSLGITAIELARGEPPHSELHP
MKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDG
QASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DNAJC3-STK24


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DNAJC3-STK24


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DNAJC3-STK24


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource