FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:DNAJC7-TBCD (FusionGDB2 ID:23573)

Fusion Gene Summary for DNAJC7-TBCD

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAJC7-TBCD
Fusion gene ID: 23573
HgeneTgene
Gene symbol

DNAJC7

TBCD

Gene ID

7266

6904

Gene nameDnaJ heat shock protein family (Hsp40) member C7tubulin folding cofactor D
SynonymsDJ11|DJC7|TPR2|TTC2PEBAT|SSD-1|tfcD
Cytomap

17q21.2

17q25.3

Type of geneprotein-codingprotein-coding
DescriptiondnaJ homolog subfamily C member 7DnaJ (Hsp40) homolog, subfamily C, member 7TPR repeat protein 2tetratricopeptide repeat domain 2tetratricopeptide repeat protein 2tubulin-specific chaperone Dbeta-tubulin cofactor D
Modification date2020031320200313
UniProtAcc

Q99615

.
Ensembl transtripts involved in fusion geneENST00000457167, ENST00000316603, 
ENST00000426588, ENST00000589547, 
ENST00000397466, ENST00000539345, 
ENST00000576691, ENST00000355528, 
Fusion gene scores* DoF score7 X 6 X 4=16819 X 22 X 13=5434
# samples 928
** MAII scorelog2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/5434*10)=-4.27851583327701
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNAJC7 [Title/Abstract] AND TBCD [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNAJC7(40169358)-TBCD(80869634), # samples:2
Anticipated loss of major functional domain due to fusion event.DNAJC7-TBCD seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DNAJC7-TBCD seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
DNAJC7-TBCD seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNAJC7

GO:0051085

chaperone cofactor-dependent protein refolding

12853476|18620420

TgeneTBCD

GO:0006457

protein folding

20740604

TgeneTBCD

GO:0007021

tubulin complex assembly

28158450

TgeneTBCD

GO:0007023

post-chaperonin tubulin folding pathway

11847227

TgeneTBCD

GO:0031115

negative regulation of microtubule polymerization

10831612|20740604


check buttonFusion gene breakpoints across DNAJC7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TBCD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AA-A01Z-01ADNAJC7chr17

40169358

-TBCDchr17

80867161

+
ChimerDB4COADTCGA-AA-A01Z-01ADNAJC7chr17

40169358

-TBCDchr17

80869634

+
ChimerDB4COADTCGA-AA-A01ZDNAJC7chr17

40169357

-TBCDchr17

80869633

+


Top

Fusion Gene ORF analysis for DNAJC7-TBCD

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000457167ENST00000397466DNAJC7chr17

40169358

-TBCDchr17

80867161

+
5CDS-intronENST00000457167ENST00000397466DNAJC7chr17

40169358

-TBCDchr17

80869634

+
5CDS-intronENST00000457167ENST00000397466DNAJC7chr17

40169357

-TBCDchr17

80869633

+
5CDS-intronENST00000457167ENST00000539345DNAJC7chr17

40169358

-TBCDchr17

80867161

+
5CDS-intronENST00000457167ENST00000539345DNAJC7chr17

40169358

-TBCDchr17

80869634

+
5CDS-intronENST00000457167ENST00000539345DNAJC7chr17

40169357

-TBCDchr17

80869633

+
5CDS-intronENST00000457167ENST00000576691DNAJC7chr17

40169358

-TBCDchr17

80867161

+
5CDS-intronENST00000457167ENST00000576691DNAJC7chr17

40169358

-TBCDchr17

80869634

+
5CDS-intronENST00000457167ENST00000576691DNAJC7chr17

40169357

-TBCDchr17

80869633

+
5UTR-3CDSENST00000316603ENST00000355528DNAJC7chr17

40169358

-TBCDchr17

80867161

+
5UTR-3CDSENST00000316603ENST00000355528DNAJC7chr17

40169358

-TBCDchr17

80869634

+
5UTR-3CDSENST00000316603ENST00000355528DNAJC7chr17

40169357

-TBCDchr17

80869633

+
5UTR-intronENST00000316603ENST00000397466DNAJC7chr17

40169358

-TBCDchr17

80867161

+
5UTR-intronENST00000316603ENST00000397466DNAJC7chr17

40169358

-TBCDchr17

80869634

+
5UTR-intronENST00000316603ENST00000397466DNAJC7chr17

40169357

-TBCDchr17

80869633

+
5UTR-intronENST00000316603ENST00000539345DNAJC7chr17

40169358

-TBCDchr17

80867161

+
5UTR-intronENST00000316603ENST00000539345DNAJC7chr17

40169358

-TBCDchr17

80869634

+
5UTR-intronENST00000316603ENST00000539345DNAJC7chr17

40169357

-TBCDchr17

80869633

+
5UTR-intronENST00000316603ENST00000576691DNAJC7chr17

40169358

-TBCDchr17

80867161

+
5UTR-intronENST00000316603ENST00000576691DNAJC7chr17

40169358

-TBCDchr17

80869634

+
5UTR-intronENST00000316603ENST00000576691DNAJC7chr17

40169357

-TBCDchr17

80869633

+
Frame-shiftENST00000457167ENST00000355528DNAJC7chr17

40169358

-TBCDchr17

80869634

+
Frame-shiftENST00000457167ENST00000355528DNAJC7chr17

40169357

-TBCDchr17

80869633

+
In-frameENST00000457167ENST00000355528DNAJC7chr17

40169358

-TBCDchr17

80867161

+
intron-3CDSENST00000426588ENST00000355528DNAJC7chr17

40169358

-TBCDchr17

80867161

+
intron-3CDSENST00000426588ENST00000355528DNAJC7chr17

40169358

-TBCDchr17

80869634

+
intron-3CDSENST00000426588ENST00000355528DNAJC7chr17

40169357

-TBCDchr17

80869633

+
intron-3CDSENST00000589547ENST00000355528DNAJC7chr17

40169358

-TBCDchr17

80867161

+
intron-3CDSENST00000589547ENST00000355528DNAJC7chr17

40169358

-TBCDchr17

80869634

+
intron-3CDSENST00000589547ENST00000355528DNAJC7chr17

40169357

-TBCDchr17

80869633

+
intron-intronENST00000426588ENST00000397466DNAJC7chr17

40169358

-TBCDchr17

80867161

+
intron-intronENST00000426588ENST00000397466DNAJC7chr17

40169358

-TBCDchr17

80869634

+
intron-intronENST00000426588ENST00000397466DNAJC7chr17

40169357

-TBCDchr17

80869633

+
intron-intronENST00000426588ENST00000539345DNAJC7chr17

40169358

-TBCDchr17

80867161

+
intron-intronENST00000426588ENST00000539345DNAJC7chr17

40169358

-TBCDchr17

80869634

+
intron-intronENST00000426588ENST00000539345DNAJC7chr17

40169357

-TBCDchr17

80869633

+
intron-intronENST00000426588ENST00000576691DNAJC7chr17

40169358

-TBCDchr17

80867161

+
intron-intronENST00000426588ENST00000576691DNAJC7chr17

40169358

-TBCDchr17

80869634

+
intron-intronENST00000426588ENST00000576691DNAJC7chr17

40169357

-TBCDchr17

80869633

+
intron-intronENST00000589547ENST00000397466DNAJC7chr17

40169358

-TBCDchr17

80867161

+
intron-intronENST00000589547ENST00000397466DNAJC7chr17

40169358

-TBCDchr17

80869634

+
intron-intronENST00000589547ENST00000397466DNAJC7chr17

40169357

-TBCDchr17

80869633

+
intron-intronENST00000589547ENST00000539345DNAJC7chr17

40169358

-TBCDchr17

80867161

+
intron-intronENST00000589547ENST00000539345DNAJC7chr17

40169358

-TBCDchr17

80869634

+
intron-intronENST00000589547ENST00000539345DNAJC7chr17

40169357

-TBCDchr17

80869633

+
intron-intronENST00000589547ENST00000576691DNAJC7chr17

40169358

-TBCDchr17

80867161

+
intron-intronENST00000589547ENST00000576691DNAJC7chr17

40169358

-TBCDchr17

80869634

+
intron-intronENST00000589547ENST00000576691DNAJC7chr17

40169357

-TBCDchr17

80869633

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000457167DNAJC7chr1740169358-ENST00000355528TBCDchr1780867161+22953143411909522

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000457167ENST00000355528DNAJC7chr1740169358-TBCDchr1780867161+0.0098606280.99013937

Top

Fusion Genomic Features for DNAJC7-TBCD


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DNAJC7chr1740169357-TBCDchr1780867160+0.0010863860.99891365
DNAJC7chr1740169357-TBCDchr1780869633+4.67E-070.9999995
DNAJC7chr1740169357-TBCDchr1780869633+4.67E-070.9999995
DNAJC7chr1740169357-TBCDchr1780867160+0.0010863860.99891365
DNAJC7chr1740169357-TBCDchr1780869633+4.67E-070.9999995
DNAJC7chr1740169357-TBCDchr1780869633+4.67E-070.9999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for DNAJC7-TBCD


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:40169358/chr17:80869634)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAJC7

Q99615

.
FUNCTION: Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity). {ECO:0000250, ECO:0000269|PubMed:12853476, ECO:0000269|PubMed:18620420}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000316603-113381_4510439.0DomainJ
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000426588-114381_4510439.0DomainJ
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000457167-114381_45125495.0DomainJ
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000316603-113142_1750439.0RepeatNote=TPR 4
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000316603-113177_2090439.0RepeatNote=TPR 5
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000316603-113210_2430439.0RepeatNote=TPR 6
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000316603-113256_2890439.0RepeatNote=TPR 7
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000316603-11328_610439.0RepeatNote=TPR 1
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000316603-113294_3270439.0RepeatNote=TPR 8
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000316603-113328_3610439.0RepeatNote=TPR 9
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000316603-11362_950439.0RepeatNote=TPR 2
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000316603-11396_1290439.0RepeatNote=TPR 3
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000426588-114142_1750439.0RepeatNote=TPR 4
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000426588-114177_2090439.0RepeatNote=TPR 5
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000426588-114210_2430439.0RepeatNote=TPR 6
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000426588-114256_2890439.0RepeatNote=TPR 7
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000426588-11428_610439.0RepeatNote=TPR 1
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000426588-114294_3270439.0RepeatNote=TPR 8
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000426588-114328_3610439.0RepeatNote=TPR 9
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000426588-11462_950439.0RepeatNote=TPR 2
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000426588-11496_1290439.0RepeatNote=TPR 3
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000457167-114142_17525495.0RepeatNote=TPR 4
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000457167-114177_20925495.0RepeatNote=TPR 5
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000457167-114210_24325495.0RepeatNote=TPR 6
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000457167-114256_28925495.0RepeatNote=TPR 7
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000457167-11428_6125495.0RepeatNote=TPR 1
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000457167-114294_32725495.0RepeatNote=TPR 8
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000457167-114328_36125495.0RepeatNote=TPR 9
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000457167-11462_9525495.0RepeatNote=TPR 2
HgeneDNAJC7chr17:40169358chr17:80867161ENST00000457167-11496_12925495.0RepeatNote=TPR 3
TgeneTBCDchr17:40169358chr17:80867161ENST000003555282039361_3996611193.0RepeatNote=HEAT 1
TgeneTBCDchr17:40169358chr17:80867161ENST000003555282039557_5946611193.0RepeatNote=HEAT 2
TgeneTBCDchr17:40169358chr17:80867161ENST000003555282039596_6326611193.0RepeatNote=HEAT 3


Top

Fusion Gene Sequence for DNAJC7-TBCD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>23573_23573_1_DNAJC7-TBCD_DNAJC7_chr17_40169358_ENST00000457167_TBCD_chr17_80867161_ENST00000355528_length(transcript)=2295nt_BP=314nt
ACGGGTAAAGTGGCGCCGCCTACGCACCGGCACAGCCCCTGGGCTCCCGCCCCGGCGCGGAGACCACCGTGGACATCCGGGGGCGGGAGG
CCGCTCTGGCCCCAAGCGGAGCCTCTCTCTGGTAGACGAGCCCGAGGGAGCCCTTCTGGGCGCGGCGCCGCGGAGCTGCTCTATGCTCCA
ACCGGAAGTGCTCTTCACCGCCGGCCTCCCACCCAGCTCTCTGGTCCCGGCGGTAAGATGGCGGCTGCCGCGGAGTGCGATGTGGTAATG
GCGGCGACCGAGCCGGAGCTGCTCGACGACCAAGAGGCGAAGAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGA
GACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTTCCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGA
TAAATGACACTTTGAGACATCTCCATCTCATCTCAAGTCACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTAT
GCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATCCCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACC
CCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGGGCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAG
GTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAAGTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCC
AGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTGTGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGG
ACGACTACACCACGGACAGCAGAGGGGACGTGGGCACCTGGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGG
CTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTGAGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTT
TCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGCACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAA
AGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGAGTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCA
CCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCCTGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTG
AGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGGGCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATG
AGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACGTGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCT
TTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCAAGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTGTTCTGCG
AGATGGTGCAGTTCCCCGGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGA
CCACGGCCAGCCAGGTGTACGAGACATTGCTCACCTACAGTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTG
ACACTGCGTGGGACGCGGAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGC
CCCAGCCTGGTGCCTGCTGAAGCCAGTCCTGGAGCCCATACCTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTG
GAAAGCCTCGCACAGTGGTGCCTCCAGCTGTTGAAGGGTAGCGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCAC
CTGCGCTCTGGTGACTTGGGGTGGACGCCTCTGCCTTCACTTGAACACAAATGTGCTTCCTATAAAATCATGTACCAAGAAGTTCCTGCC
TTTTGTCTCTGAGCCTGATGTGTGTAGGGGTGATGGAAAGGCTCACTGCCCAGGGGTCAGCCAGAGGGGAGGTGGGCTGCACTCCTCCTG

>23573_23573_1_DNAJC7-TBCD_DNAJC7_chr17_40169358_ENST00000457167_TBCD_chr17_80867161_ENST00000355528_length(amino acids)=522AA_BP=
MGGQLMRQAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQY
LAELRNPEEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYC
ALLGCMDDYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVP
HRGELEKLFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIF
EDNLLNERVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVFCEMVQFPGDVRRQALLQLCLLLCHR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DNAJC7-TBCD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DNAJC7-TBCD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for DNAJC7-TBCD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource