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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DNAL1-KPNA1 (FusionGDB2 ID:23594)

Fusion Gene Summary for DNAL1-KPNA1

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAL1-KPNA1
Fusion gene ID: 23594
HgeneTgene
Gene symbol

DNAL1

KPNA1

Gene ID

83544

3836

Gene namedynein axonemal light chain 1karyopherin subunit alpha 1
SynonymsC14orf168|CILD16|LC1IPOA5|NPI-1|RCH2|SRP1
Cytomap

14q24.3

3q21.1

Type of geneprotein-codingprotein-coding
Descriptiondynein light chain 1, axonemalimportin subunit alpha-5RAG cohort protein 2SRP1-betaimportin alpha 5importin subunit alpha-1importin-alpha-S1karyopherin alpha 1 (importin alpha 5)nucleoprotein interactor 1recombination activating gene cohort 2
Modification date2020031320200313
UniProtAcc

Q4LDG9

P52294

Ensembl transtripts involved in fusion geneENST00000553645, ENST00000554339, 
ENST00000311089, ENST00000554871, 
ENST00000540526, 		ENST00000466923, 
ENST00000344337, 
Fusion gene scores* DoF score6 X 6 X 3=1083 X 3 X 2=18
# samples 63
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DNAL1 [Title/Abstract] AND KPNA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNAL1(74111745)-KPNA1(122152635), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DNAL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KPNA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-FP-7916DNAL1chr14

74111745

+KPNA1chr3

122152635

-


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Fusion Gene ORF analysis for DNAL1-KPNA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000553645ENST00000466923DNAL1chr14

74111745

+KPNA1chr3

122152635

-
5CDS-5UTRENST00000554339ENST00000466923DNAL1chr14

74111745

+KPNA1chr3

122152635

-
5UTR-3CDSENST00000311089ENST00000344337DNAL1chr14

74111745

+KPNA1chr3

122152635

-
5UTR-3CDSENST00000554871ENST00000344337DNAL1chr14

74111745

+KPNA1chr3

122152635

-
5UTR-5UTRENST00000311089ENST00000466923DNAL1chr14

74111745

+KPNA1chr3

122152635

-
5UTR-5UTRENST00000554871ENST00000466923DNAL1chr14

74111745

+KPNA1chr3

122152635

-
In-frameENST00000553645ENST00000344337DNAL1chr14

74111745

+KPNA1chr3

122152635

-
In-frameENST00000554339ENST00000344337DNAL1chr14

74111745

+KPNA1chr3

122152635

-
intron-3CDSENST00000540526ENST00000344337DNAL1chr14

74111745

+KPNA1chr3

122152635

-
intron-5UTRENST00000540526ENST00000466923DNAL1chr14

74111745

+KPNA1chr3

122152635

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000553645DNAL1chr1474111745+ENST00000344337KPNA1chr3122152635-55754441538165
ENST00000554339DNAL1chr1474111745+ENST00000344337KPNA1chr3122152635-55562522519165

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000553645ENST00000344337DNAL1chr1474111745+KPNA1chr3122152635-0.0012231180.99877685
ENST00000554339ENST00000344337DNAL1chr1474111745+KPNA1chr3122152635-0.0012114580.99878854

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Fusion Genomic Features for DNAL1-KPNA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DNAL1-KPNA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:74111745/chr3:122152635)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAL1

Q4LDG9

KPNA1

P52294

FUNCTION: Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry (PubMed:21496787). {ECO:0000250|UniProtKB:Q9XHH2, ECO:0000303|PubMed:21496787}.FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKPNA1chr14:74111745chr3:122152635ENST000003443371014373_412374539.0RepeatNote=ARM 8
TgeneKPNA1chr14:74111745chr3:122152635ENST000003443371014413_457374539.0RepeatNote=ARM 9
TgeneKPNA1chr14:74111745chr3:122152635ENST000003443371014460_504374539.0RepeatNote=ARM 10%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNAL1chr14:74111745chr3:122152635ENST00000311089+17150_190078.0DomainNote=LRRCT
HgeneDNAL1chr14:74111745chr3:122152635ENST00000540526+18150_1900152.0DomainNote=LRRCT
HgeneDNAL1chr14:74111745chr3:122152635ENST00000553645+18150_1901191.0DomainNote=LRRCT
HgeneDNAL1chr14:74111745chr3:122152635ENST00000554871+19150_1900152.0DomainNote=LRRCT
HgeneDNAL1chr14:74111745chr3:122152635ENST00000311089+17116_137078.0RepeatNote=LRR 4
HgeneDNAL1chr14:74111745chr3:122152635ENST00000311089+1749_70078.0RepeatNote=LRR 1
HgeneDNAL1chr14:74111745chr3:122152635ENST00000311089+1771_92078.0RepeatNote=LRR 2
HgeneDNAL1chr14:74111745chr3:122152635ENST00000311089+1794_115078.0RepeatNote=LRR 3
HgeneDNAL1chr14:74111745chr3:122152635ENST00000540526+18116_1370152.0RepeatNote=LRR 4
HgeneDNAL1chr14:74111745chr3:122152635ENST00000540526+1849_700152.0RepeatNote=LRR 1
HgeneDNAL1chr14:74111745chr3:122152635ENST00000540526+1871_920152.0RepeatNote=LRR 2
HgeneDNAL1chr14:74111745chr3:122152635ENST00000540526+1894_1150152.0RepeatNote=LRR 3
HgeneDNAL1chr14:74111745chr3:122152635ENST00000553645+18116_1371191.0RepeatNote=LRR 4
HgeneDNAL1chr14:74111745chr3:122152635ENST00000553645+1849_701191.0RepeatNote=LRR 1
HgeneDNAL1chr14:74111745chr3:122152635ENST00000553645+1871_921191.0RepeatNote=LRR 2
HgeneDNAL1chr14:74111745chr3:122152635ENST00000553645+1894_1151191.0RepeatNote=LRR 3
HgeneDNAL1chr14:74111745chr3:122152635ENST00000554871+19116_1370152.0RepeatNote=LRR 4
HgeneDNAL1chr14:74111745chr3:122152635ENST00000554871+1949_700152.0RepeatNote=LRR 1
HgeneDNAL1chr14:74111745chr3:122152635ENST00000554871+1971_920152.0RepeatNote=LRR 2
HgeneDNAL1chr14:74111745chr3:122152635ENST00000554871+1994_1150152.0RepeatNote=LRR 3
TgeneKPNA1chr14:74111745chr3:122152635ENST00000344337101425_28374539.0Compositional biasNote=Poly-Arg
TgeneKPNA1chr14:74111745chr3:122152635ENST0000034433710141_57374539.0DomainIBB
TgeneKPNA1chr14:74111745chr3:122152635ENST00000344337101442_51374539.0MotifNuclear localization signal
TgeneKPNA1chr14:74111745chr3:122152635ENST000003443371014149_241374539.0RegionNLS binding site (major)
TgeneKPNA1chr14:74111745chr3:122152635ENST000003443371014245_437374539.0RegionNote=Binding to RAG1
TgeneKPNA1chr14:74111745chr3:122152635ENST000003443371014318_406374539.0RegionNLS binding site (minor)
TgeneKPNA1chr14:74111745chr3:122152635ENST000003443371014118_161374539.0RepeatNote=ARM 2
TgeneKPNA1chr14:74111745chr3:122152635ENST000003443371014162_206374539.0RepeatNote=ARM 3
TgeneKPNA1chr14:74111745chr3:122152635ENST000003443371014207_245374539.0RepeatNote=ARM 4
TgeneKPNA1chr14:74111745chr3:122152635ENST000003443371014246_290374539.0RepeatNote=ARM 5
TgeneKPNA1chr14:74111745chr3:122152635ENST000003443371014291_330374539.0RepeatNote=ARM 6
TgeneKPNA1chr14:74111745chr3:122152635ENST000003443371014331_372374539.0RepeatNote=ARM 7
TgeneKPNA1chr14:74111745chr3:122152635ENST00000344337101477_117374539.0RepeatNote=ARM 1%3B truncated


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Fusion Gene Sequence for DNAL1-KPNA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>23594_23594_1_DNAL1-KPNA1_DNAL1_chr14_74111745_ENST00000553645_KPNA1_chr3_122152635_ENST00000344337_length(transcript)=5575nt_BP=44nt
GGGCCCTAGCAACCAGAGCAGTGACAGTAGCAACCGCCGGAATGACTGTGATAGATGCCAACATTTTCCCAGCCCTCATTAGTATTTTAC
AAACTGCTGAATTTCGGACAAGAAAAGAAGCAGCTTGGGCCATCACAAATGCAACTTCTGGAGGATCAGCTGAACAGATCAAGTACCTAG
TAGAACTGGGTTGTATCAAGCCGCTCTGTGATCTCCTCACGGTCATGGACTCTAAGATTGTACAGGTTGCCCTAAATGGCTTGGAAAATA
TCCTGAGGCTTGGAGAACAGGAAGCCAAAAGGAATGGCACTGGCATTAACCCTTACTGTGCTTTGATTGAAGAAGCTTATGGTCTGGATA
AAATTGAGTTCTTACAGAGTCATGAAAACCAGGAGATCTACCAAAAGGCCTTTGATCTTATTGAGCATTACTTCGGGACCGAAGATGAAG
ACAGCAGCATTGCACCCCAGGTTGACCTTAACCAGCAGCAGTACATCTTCCAACAGTGTGAGGCTCCTATGGAAGGTTTCCAGCTTTGAA
GCAATACTCTGCTTTCACGTACCTGTGTCAGACCAGGCTACCCAGTCGAGTCCTCTTGTGGAGCCCACAGTCCTCATGGAGCTAACTTCT
CAAATGTTTTCCATAATACTGTTTGCGCTCATTTGCTTGCCTTGCGCACCTGCTCTCTTACACACATCTGGAAAACCTCCGGCTCTCTGT
GGTGGAATACCCTTCTAATAAAAGGGTAACCAGAACGGCCCACTCTCTTTTACGGAAAAATCCCTAGGCTTTGGAGATCCGCACTTACAT
TAGAGTTATGGGAATATACACATATTAATGTGGCTCCCTTTTTCTTGTGGGGGAATAAAAGAGGACTCCTCCTCATTCCCTTTAACATGG
GGGAAAAAACTGACATTAAAAGATGAGACTAAATCTTTATCTTGAATTTTACACAACTACTTACGACAAGGGAGATGTTTAGACCTGTTG
TGTATACTTCAGAGTACTTTTCATGAGTTCTTCCACAGTGAACCCTTGGATTACCTGGTGGCTTTTTCTAGCCAGATTTGCATTAATCCT
TACTGAGATTGGATGGTTTTCTTTCCTCTATTGGCGCCATTCTTCAGATATTAAAGTTAAACCATCCACTCCCTCACCTTCAGCCTTCAG
TGAATGTGCTTTCTAGTTGTCAGGAATGCTGAAGAATTAACACTTTGACTCCTAAATGTGATACTGGTTTGTAGATTCCCTTAGAGCAGA
AAGGAGAGGGGCACATATTAATTTGTATCGCTTTTGCTTCTCTTTGGTCTTTTGTGTCTTAGAATTTGGAAGTGGTTCATTTCTGTTGCT
GGTATGAGGATTTCGAATACTTAGTAATCGAAAACCATATCCTGTAATTTAATAAAAAAAACTAAGGACGAAAAAACCCTCCAATTTTCC
CAAATGCAATCAGTGTAACTAGGGGCTGTGTTTCTGCATTAAAATAAATGTTTCAGGCTTTGTGGTCCTGATCAAGGTCCTCATTAAAAA
ATTGGAGTTCACCCTAGGTGCTTTTCCCCTCTGTGACTGGCAGATAACACATACTTTTGAAAGTAACTTTGGGATTTTTTTCTTAGGTGC
AGCTCGATTCTAATCTTTTCATGCTGCACACGATTCCTTTAATGTAGCATCCTTATCTGAAAGAAATAACCATCTTCTCAACATGACCTG
CTTAACCCAAATAAGAACAGTGATCTTATAACCTCATTGTTTCCTAATCATTTTATTTCATCTCCTGCTAGTACTGTGCCGCTTCCCCCT
CCCCCCACACAAAATAAAAACAGTATCTGCCTTCTGGCTCATTTAATGATGACTGCAATCTGTACCTGCAAATGGCGCTTCCAGTACTGT
GTTCAGTGATCCACATTTGTGCTTGGACTGGAATGAAAAAATACGCTTAATTGCCAAGACAACTGCAAATGAGTTCAATACGACTTCTCG
GTGCTAGTTGGCCATCTTGACTCAATGTTGGGATACACTACCAGAGAAGATTTTTTTGTTGATGTGCTGTTCAAAGTGAATTCTGAAGGA
AAAGGTTGCTCACCTCTGTTTCAGAGCATACCCTTTTAAACCTTTTTAGACTTGTCCTCTTCTAGAATTCATTATAACCCCAAAGTGTAA
AAACTATTTGGAAGTTGCCCCTGACAAGCTATTATACATCTCTGGTAAATCCTGCTGAATGTAAGGGATATTCAGAGCTTTTCATACCTC
ATCATGATGTTATTTAAGCAGCCAACTTATGTGACCTGATTTAAACTTTTAAAAAATCCACTTCATTCAAACTAGAAAGAGTCAAAGACA
AAGGACATTTATCAGCCAAGAGTGTGACGCATTCTTCGCATCTAGTCTGTAGTAGTGTCTGTGCTCTGGGATGGATACCGTCTGATGTCT
GTTTGTTATTGATGGCGCAGCCACTGCAAAACTAGTCAACTCCCATCTATAACTGTTACTTTTTCTAGTGCTGCTTTGTGCTGAGAGAAC
ATTTTAGTTTACTGCACTTGACCTGTAAAAGACTGATTCTTTGTAATTTTAGGGATAAATTAGGTGGTTAATTTAAAGAAGAAATTTCAA
TGTTGCCTTTACATCACATTAAAATATAACTTCTTTCAGAAGGATAATAGAAGCACTGATTCATAGTAAAAATCTTGTTTTTAGCTTTGA
CTTTTTTGTGGCTGTTTTTTAAAATTGTAAATTACTAGTAACATGTCATTTCTATAGGATGTTTTAAATTATGTACCTTCCATTGGATAG
TTAAAATAATTTCATTTTATAAGCCAATTTGAGTGGGAAAGATACAAAGCACACAGTTGTCTCCCCACATTAGGAAGAGTAGTGTGCATT
CAGACATTCGGAATTTTTGCTAGTAGTTGGAGATGTTTCAGTGAGTGAATTAAAACAAAGTCTATTTAACTGACGTGATCTATTTTGTGT
CTAAAACAGAGGAATTTATCTTGTCCTAGAAGTTCATGAACTATAAGATCTAAGTTTTTTTTTCTTTTTTAACAATAAAATGATTTTTTC
TTAAAGTATCAAAGTTGGAATTGGCTAAAAGTGAAGTAGCATAACTCAGATATGTTGGAACTTGGTACTGAAGCAGGCTTTTTGGTAACA
GAAATGACATTTTAAGGGGTAACTGTATATCCTGTTTTTAGTTCTTTGCCTCTCAGATTCTGTTAACTTAGTTTAAATTCACTGAATACC
CTACCACTAAGGCGTTGCTCATTACAAAAGCATGTTAATTTCAATACAGGAAAACTCTTTTGTAGTTTTATATATGGATTGGGGAAAGTG
ACTTTGTTTTACTTTTCCTTTTTATTCCCCTCCATCCTCCAAACTTCCAATCTATATTATTTGTAATGAGAACTTTGGTGGGGGAAAAAA
AGCATTAAGAGAATTTTGGATGTAAAGGCATCTGGTATCTGATGGACCAGCAGGTAGATGTGGTTGGATTGAGAAATTTTGGGTAAGGTA
GATGATAGAAGAAAGAGATTTTAGGAGACACAGTTCTCTGTGGAACACTTTCTTTCATGTTCCTGTAACTAATTGATCAAGACCCTTTTA
AACGCTTATCTTTGTCAGTTCCGCTTTTGAAAAAACTATTGCCCTAGGATTGTTTCTTCCATATGACAGATGAAGGTTATTGGCTCTGAG
TCATTTTTGGCATTATCGTCACAGATAAAAAGATTGGCAATTAATCTCATAAAAAATCTGAATTATTCCAGATTGCTGCCGATTTTTGCC
TAAGAAACAATATGTAAGTATATTTTATAAACCAAACTTTGTCAACCAATTCTATTGTACGTCTACCCACAGGCAACTTTGAATTTACTT
CTCTAGTGCTAAATAAACATTTCAGCGATTTAATCCCCCAACTTGGGGGATGCATTATGAAAAGGTTTTCCTGGAGTCAAGGGGTTTTTC
TTTCTCGCTAGTTTTGTGAAAATTTTTATATCAATAGGCAAATCATTATAACTTTTTAGGGGTTGATGGTTTTTAAGTATATTGGAAATT
GTGGTGTCTAAGGATGATGTTCAGTGAAGAAAAGGGATCCACTTTTAGAAACCAGCATTGTTTGCTTTCAACTTTCATACTGTATGCTAA
CTCCTACGTTCCAAAATGTGCTCATTTGCAGACACAGGTATGCCTATATACATGGAAGTCTCAAATCTGAATTTTTATCCATCTCAATAT
GACCATTTCTCTCTGTTGTGAGCTGAACAGATTAAGTATATATCTGCCAGGTTGGGAAATATTTTGGTCTATCTTTTCCTGTCATCAGAA
CTTAATTTAAAAAAATTATCAAAGGTCAGATGTGACTACTACAGTAAGTTGGCTATCATAAAGAATATTCCATAAAATGTTTTATCTGCC
ATACAAAATTACTGGGTTTATGGCCGGATGTGGTGGCTCATGCCTGTAATCCCAGCAGTTCAGGATTACAGGTTATATACAGGTTATAAC
AATGGATACCAGGACATCAGAATATCTGATAAAGCAAATATTTATATGCTAATTTAAAATATCAAATTGCTACTGGACATAAAATACATC
TGGAAGCTTGGGGTAAGAAGAAAGAAAAGAAGTGTTCCGTTCTGTTTTCAACTAAGGGTAAACGAAGTCCCAGAGTGTTTTCCCTGTAGG
TCAAATTAAGGTAACATGTCTTTATTTGATCATCTATTGTACACCAGATACCTGGCTAAGGGCTTTCCTTTTTTCTCATGTAGTCTTCCA
AATGTTCTTTGATAATTGTCACTATATTATAGATGACAAAGTGAAGACTTACGAGAAATTACTTTGCCCCAAGGTTACAACACTTAGATG
GCTGTCCAAGGGCGGGGAAGAGCCCTGCAAATTCTGTGTCTTGAAGAAAGCAGTGGCCACGCAGTAGTTCCGTGCCCAGGATCTCCCAGA
ACTAGACTTGGCAACCACAGCTGGGCCAGCCTTTTTTGTTAGACCATTCTTCCTGACTCCTGCTTACCATCAGCACCCTTAAAATGACGA
AATCAGGCTTAAGTTGCTTTTAGGTTACACAGACTGGAGTGTAGGCCCTCTCAGGCCAAACATCTTTCCTCTTCTGTGGTGCTAAAATTC
TGTATGACCAGACAAGTATGGTAATAGGTTTTTTTTTTTTTTTTTTTTGTGCAAATGATTTTGTGTTTAGTAAAATAATGGCTAAACACA
TGGATCCATTCAAACGCACAAATGTGGAAAGTATTGACACGGAAGGAAAGGCTTTGAAGAATTACTGCCTCAGGAAGCAGTGCCATGGAT
GCGAATTTAACACAGTCTACTTCTTCCTAAAGGAATATCATCCCAAGGAATGTCAAAAATTAAAATCACCTTTTAATGTACTGGTTGTTG
AGTGTTTCTGCTTTACCTCAAGTCATTCTGACCACTCTACATCCTGCTTCAAAGTGTTCTGACACTTAGATTTGGAATGGCTCTAATGAT

>23594_23594_1_DNAL1-KPNA1_DNAL1_chr14_74111745_ENST00000553645_KPNA1_chr3_122152635_ENST00000344337_length(amino acids)=165AA_BP=1
MTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGT

--------------------------------------------------------------
>23594_23594_2_DNAL1-KPNA1_DNAL1_chr14_74111745_ENST00000554339_KPNA1_chr3_122152635_ENST00000344337_length(transcript)=5556nt_BP=25nt
AGTGACAGTAGCAACCGCCGGAATGACTGTGATAGATGCCAACATTTTCCCAGCCCTCATTAGTATTTTACAAACTGCTGAATTTCGGAC
AAGAAAAGAAGCAGCTTGGGCCATCACAAATGCAACTTCTGGAGGATCAGCTGAACAGATCAAGTACCTAGTAGAACTGGGTTGTATCAA
GCCGCTCTGTGATCTCCTCACGGTCATGGACTCTAAGATTGTACAGGTTGCCCTAAATGGCTTGGAAAATATCCTGAGGCTTGGAGAACA
GGAAGCCAAAAGGAATGGCACTGGCATTAACCCTTACTGTGCTTTGATTGAAGAAGCTTATGGTCTGGATAAAATTGAGTTCTTACAGAG
TCATGAAAACCAGGAGATCTACCAAAAGGCCTTTGATCTTATTGAGCATTACTTCGGGACCGAAGATGAAGACAGCAGCATTGCACCCCA
GGTTGACCTTAACCAGCAGCAGTACATCTTCCAACAGTGTGAGGCTCCTATGGAAGGTTTCCAGCTTTGAAGCAATACTCTGCTTTCACG
TACCTGTGTCAGACCAGGCTACCCAGTCGAGTCCTCTTGTGGAGCCCACAGTCCTCATGGAGCTAACTTCTCAAATGTTTTCCATAATAC
TGTTTGCGCTCATTTGCTTGCCTTGCGCACCTGCTCTCTTACACACATCTGGAAAACCTCCGGCTCTCTGTGGTGGAATACCCTTCTAAT
AAAAGGGTAACCAGAACGGCCCACTCTCTTTTACGGAAAAATCCCTAGGCTTTGGAGATCCGCACTTACATTAGAGTTATGGGAATATAC
ACATATTAATGTGGCTCCCTTTTTCTTGTGGGGGAATAAAAGAGGACTCCTCCTCATTCCCTTTAACATGGGGGAAAAAACTGACATTAA
AAGATGAGACTAAATCTTTATCTTGAATTTTACACAACTACTTACGACAAGGGAGATGTTTAGACCTGTTGTGTATACTTCAGAGTACTT
TTCATGAGTTCTTCCACAGTGAACCCTTGGATTACCTGGTGGCTTTTTCTAGCCAGATTTGCATTAATCCTTACTGAGATTGGATGGTTT
TCTTTCCTCTATTGGCGCCATTCTTCAGATATTAAAGTTAAACCATCCACTCCCTCACCTTCAGCCTTCAGTGAATGTGCTTTCTAGTTG
TCAGGAATGCTGAAGAATTAACACTTTGACTCCTAAATGTGATACTGGTTTGTAGATTCCCTTAGAGCAGAAAGGAGAGGGGCACATATT
AATTTGTATCGCTTTTGCTTCTCTTTGGTCTTTTGTGTCTTAGAATTTGGAAGTGGTTCATTTCTGTTGCTGGTATGAGGATTTCGAATA
CTTAGTAATCGAAAACCATATCCTGTAATTTAATAAAAAAAACTAAGGACGAAAAAACCCTCCAATTTTCCCAAATGCAATCAGTGTAAC
TAGGGGCTGTGTTTCTGCATTAAAATAAATGTTTCAGGCTTTGTGGTCCTGATCAAGGTCCTCATTAAAAAATTGGAGTTCACCCTAGGT
GCTTTTCCCCTCTGTGACTGGCAGATAACACATACTTTTGAAAGTAACTTTGGGATTTTTTTCTTAGGTGCAGCTCGATTCTAATCTTTT
CATGCTGCACACGATTCCTTTAATGTAGCATCCTTATCTGAAAGAAATAACCATCTTCTCAACATGACCTGCTTAACCCAAATAAGAACA
GTGATCTTATAACCTCATTGTTTCCTAATCATTTTATTTCATCTCCTGCTAGTACTGTGCCGCTTCCCCCTCCCCCCACACAAAATAAAA
ACAGTATCTGCCTTCTGGCTCATTTAATGATGACTGCAATCTGTACCTGCAAATGGCGCTTCCAGTACTGTGTTCAGTGATCCACATTTG
TGCTTGGACTGGAATGAAAAAATACGCTTAATTGCCAAGACAACTGCAAATGAGTTCAATACGACTTCTCGGTGCTAGTTGGCCATCTTG
ACTCAATGTTGGGATACACTACCAGAGAAGATTTTTTTGTTGATGTGCTGTTCAAAGTGAATTCTGAAGGAAAAGGTTGCTCACCTCTGT
TTCAGAGCATACCCTTTTAAACCTTTTTAGACTTGTCCTCTTCTAGAATTCATTATAACCCCAAAGTGTAAAAACTATTTGGAAGTTGCC
CCTGACAAGCTATTATACATCTCTGGTAAATCCTGCTGAATGTAAGGGATATTCAGAGCTTTTCATACCTCATCATGATGTTATTTAAGC
AGCCAACTTATGTGACCTGATTTAAACTTTTAAAAAATCCACTTCATTCAAACTAGAAAGAGTCAAAGACAAAGGACATTTATCAGCCAA
GAGTGTGACGCATTCTTCGCATCTAGTCTGTAGTAGTGTCTGTGCTCTGGGATGGATACCGTCTGATGTCTGTTTGTTATTGATGGCGCA
GCCACTGCAAAACTAGTCAACTCCCATCTATAACTGTTACTTTTTCTAGTGCTGCTTTGTGCTGAGAGAACATTTTAGTTTACTGCACTT
GACCTGTAAAAGACTGATTCTTTGTAATTTTAGGGATAAATTAGGTGGTTAATTTAAAGAAGAAATTTCAATGTTGCCTTTACATCACAT
TAAAATATAACTTCTTTCAGAAGGATAATAGAAGCACTGATTCATAGTAAAAATCTTGTTTTTAGCTTTGACTTTTTTGTGGCTGTTTTT
TAAAATTGTAAATTACTAGTAACATGTCATTTCTATAGGATGTTTTAAATTATGTACCTTCCATTGGATAGTTAAAATAATTTCATTTTA
TAAGCCAATTTGAGTGGGAAAGATACAAAGCACACAGTTGTCTCCCCACATTAGGAAGAGTAGTGTGCATTCAGACATTCGGAATTTTTG
CTAGTAGTTGGAGATGTTTCAGTGAGTGAATTAAAACAAAGTCTATTTAACTGACGTGATCTATTTTGTGTCTAAAACAGAGGAATTTAT
CTTGTCCTAGAAGTTCATGAACTATAAGATCTAAGTTTTTTTTTCTTTTTTAACAATAAAATGATTTTTTCTTAAAGTATCAAAGTTGGA
ATTGGCTAAAAGTGAAGTAGCATAACTCAGATATGTTGGAACTTGGTACTGAAGCAGGCTTTTTGGTAACAGAAATGACATTTTAAGGGG
TAACTGTATATCCTGTTTTTAGTTCTTTGCCTCTCAGATTCTGTTAACTTAGTTTAAATTCACTGAATACCCTACCACTAAGGCGTTGCT
CATTACAAAAGCATGTTAATTTCAATACAGGAAAACTCTTTTGTAGTTTTATATATGGATTGGGGAAAGTGACTTTGTTTTACTTTTCCT
TTTTATTCCCCTCCATCCTCCAAACTTCCAATCTATATTATTTGTAATGAGAACTTTGGTGGGGGAAAAAAAGCATTAAGAGAATTTTGG
ATGTAAAGGCATCTGGTATCTGATGGACCAGCAGGTAGATGTGGTTGGATTGAGAAATTTTGGGTAAGGTAGATGATAGAAGAAAGAGAT
TTTAGGAGACACAGTTCTCTGTGGAACACTTTCTTTCATGTTCCTGTAACTAATTGATCAAGACCCTTTTAAACGCTTATCTTTGTCAGT
TCCGCTTTTGAAAAAACTATTGCCCTAGGATTGTTTCTTCCATATGACAGATGAAGGTTATTGGCTCTGAGTCATTTTTGGCATTATCGT
CACAGATAAAAAGATTGGCAATTAATCTCATAAAAAATCTGAATTATTCCAGATTGCTGCCGATTTTTGCCTAAGAAACAATATGTAAGT
ATATTTTATAAACCAAACTTTGTCAACCAATTCTATTGTACGTCTACCCACAGGCAACTTTGAATTTACTTCTCTAGTGCTAAATAAACA
TTTCAGCGATTTAATCCCCCAACTTGGGGGATGCATTATGAAAAGGTTTTCCTGGAGTCAAGGGGTTTTTCTTTCTCGCTAGTTTTGTGA
AAATTTTTATATCAATAGGCAAATCATTATAACTTTTTAGGGGTTGATGGTTTTTAAGTATATTGGAAATTGTGGTGTCTAAGGATGATG
TTCAGTGAAGAAAAGGGATCCACTTTTAGAAACCAGCATTGTTTGCTTTCAACTTTCATACTGTATGCTAACTCCTACGTTCCAAAATGT
GCTCATTTGCAGACACAGGTATGCCTATATACATGGAAGTCTCAAATCTGAATTTTTATCCATCTCAATATGACCATTTCTCTCTGTTGT
GAGCTGAACAGATTAAGTATATATCTGCCAGGTTGGGAAATATTTTGGTCTATCTTTTCCTGTCATCAGAACTTAATTTAAAAAAATTAT
CAAAGGTCAGATGTGACTACTACAGTAAGTTGGCTATCATAAAGAATATTCCATAAAATGTTTTATCTGCCATACAAAATTACTGGGTTT
ATGGCCGGATGTGGTGGCTCATGCCTGTAATCCCAGCAGTTCAGGATTACAGGTTATATACAGGTTATAACAATGGATACCAGGACATCA
GAATATCTGATAAAGCAAATATTTATATGCTAATTTAAAATATCAAATTGCTACTGGACATAAAATACATCTGGAAGCTTGGGGTAAGAA
GAAAGAAAAGAAGTGTTCCGTTCTGTTTTCAACTAAGGGTAAACGAAGTCCCAGAGTGTTTTCCCTGTAGGTCAAATTAAGGTAACATGT
CTTTATTTGATCATCTATTGTACACCAGATACCTGGCTAAGGGCTTTCCTTTTTTCTCATGTAGTCTTCCAAATGTTCTTTGATAATTGT
CACTATATTATAGATGACAAAGTGAAGACTTACGAGAAATTACTTTGCCCCAAGGTTACAACACTTAGATGGCTGTCCAAGGGCGGGGAA
GAGCCCTGCAAATTCTGTGTCTTGAAGAAAGCAGTGGCCACGCAGTAGTTCCGTGCCCAGGATCTCCCAGAACTAGACTTGGCAACCACA
GCTGGGCCAGCCTTTTTTGTTAGACCATTCTTCCTGACTCCTGCTTACCATCAGCACCCTTAAAATGACGAAATCAGGCTTAAGTTGCTT
TTAGGTTACACAGACTGGAGTGTAGGCCCTCTCAGGCCAAACATCTTTCCTCTTCTGTGGTGCTAAAATTCTGTATGACCAGACAAGTAT
GGTAATAGGTTTTTTTTTTTTTTTTTTTTGTGCAAATGATTTTGTGTTTAGTAAAATAATGGCTAAACACATGGATCCATTCAAACGCAC
AAATGTGGAAAGTATTGACACGGAAGGAAAGGCTTTGAAGAATTACTGCCTCAGGAAGCAGTGCCATGGATGCGAATTTAACACAGTCTA
CTTCTTCCTAAAGGAATATCATCCCAAGGAATGTCAAAAATTAAAATCACCTTTTAATGTACTGGTTGTTGAGTGTTTCTGCTTTACCTC
AAGTCATTCTGACCACTCTACATCCTGCTTCAAAGTGTTCTGACACTTAGATTTGGAATGGCTCTAATGATTCTTTGTACTTGAATGTGG

>23594_23594_2_DNAL1-KPNA1_DNAL1_chr14_74111745_ENST00000554339_KPNA1_chr3_122152635_ENST00000344337_length(amino acids)=165AA_BP=1
MTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGT

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Fusion Gene PPI Analysis for DNAL1-KPNA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DNAL1-KPNA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DNAL1-KPNA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource