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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DNALI1-ARHGEF6 (FusionGDB2 ID:23598)

Fusion Gene Summary for DNALI1-ARHGEF6

check button Fusion gene summary
Fusion gene informationFusion gene name: DNALI1-ARHGEF6
Fusion gene ID: 23598
HgeneTgene
Gene symbol

DNALI1

ARHGEF6

Gene ID

7802

9459

Gene namedynein axonemal light intermediate chain 1Rac/Cdc42 guanine nucleotide exchange factor 6
SynonymsP28|dJ423B22.5|hp28COOL2|Cool-2|MRX46|PIXA|alpha-PIX|alphaPIX
Cytomap

1p34.3

Xq26.3

Type of geneprotein-codingprotein-coding
Descriptionaxonemal dynein light intermediate polypeptide 1dJ423B22.5 (axonemal dynein light chain (hp28))dynein, axonemal, light intermediate polypeptide 1inner dynein arm light chain, axonemalinner dynein arm, homolog of clamydomonasrho guanine nucleotide exchange factor 6PAK-interacting exchange factor, alphaRac/Cdc42 guanine exchange factor (GEF) 6Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
Modification date2020032720200327
UniProtAcc.

Q15052

Ensembl transtripts involved in fusion geneENST00000296218, ENST00000541606, 
ENST00000497858, 		ENST00000250617, 
ENST00000370620, ENST00000370622, 
ENST00000535227, 
Fusion gene scores* DoF score2 X 3 X 2=124 X 3 X 3=36
# samples 24
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DNALI1 [Title/Abstract] AND ARHGEF6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNALI1(38025097)-ARHGEF6(135790929), # samples:1
DNALI1(38023349)-ARHGEF6(135790929), # samples:1
Anticipated loss of major functional domain due to fusion event.DNALI1-ARHGEF6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DNALI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARHGEF6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-71-8520-01ADNALI1chr1

38023349

-ARHGEF6chrX

135790929

-
ChimerDB4LUADTCGA-71-8520-01ADNALI1chr1

38025097

+ARHGEF6chrX

135790929

-


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Fusion Gene ORF analysis for DNALI1-ARHGEF6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000296218ENST00000250617DNALI1chr1

38025097

+ARHGEF6chrX

135790929

-
Frame-shiftENST00000296218ENST00000370620DNALI1chr1

38025097

+ARHGEF6chrX

135790929

-
Frame-shiftENST00000296218ENST00000370622DNALI1chr1

38025097

+ARHGEF6chrX

135790929

-
Frame-shiftENST00000296218ENST00000535227DNALI1chr1

38025097

+ARHGEF6chrX

135790929

-
Frame-shiftENST00000541606ENST00000250617DNALI1chr1

38023349

-ARHGEF6chrX

135790929

-
Frame-shiftENST00000541606ENST00000370620DNALI1chr1

38023349

-ARHGEF6chrX

135790929

-
Frame-shiftENST00000541606ENST00000370622DNALI1chr1

38023349

-ARHGEF6chrX

135790929

-
Frame-shiftENST00000541606ENST00000535227DNALI1chr1

38023349

-ARHGEF6chrX

135790929

-
In-frameENST00000296218ENST00000250617DNALI1chr1

38023349

-ARHGEF6chrX

135790929

-
In-frameENST00000296218ENST00000370620DNALI1chr1

38023349

-ARHGEF6chrX

135790929

-
In-frameENST00000296218ENST00000370622DNALI1chr1

38023349

-ARHGEF6chrX

135790929

-
In-frameENST00000296218ENST00000535227DNALI1chr1

38023349

-ARHGEF6chrX

135790929

-
intron-3CDSENST00000497858ENST00000250617DNALI1chr1

38023349

-ARHGEF6chrX

135790929

-
intron-3CDSENST00000497858ENST00000250617DNALI1chr1

38025097

+ARHGEF6chrX

135790929

-
intron-3CDSENST00000497858ENST00000370620DNALI1chr1

38023349

-ARHGEF6chrX

135790929

-
intron-3CDSENST00000497858ENST00000370620DNALI1chr1

38025097

+ARHGEF6chrX

135790929

-
intron-3CDSENST00000497858ENST00000370622DNALI1chr1

38023349

-ARHGEF6chrX

135790929

-
intron-3CDSENST00000497858ENST00000370622DNALI1chr1

38025097

+ARHGEF6chrX

135790929

-
intron-3CDSENST00000497858ENST00000535227DNALI1chr1

38023349

-ARHGEF6chrX

135790929

-
intron-3CDSENST00000497858ENST00000535227DNALI1chr1

38025097

+ARHGEF6chrX

135790929

-
intron-3CDSENST00000541606ENST00000250617DNALI1chr1

38025097

+ARHGEF6chrX

135790929

-
intron-3CDSENST00000541606ENST00000370620DNALI1chr1

38025097

+ARHGEF6chrX

135790929

-
intron-3CDSENST00000541606ENST00000370622DNALI1chr1

38025097

+ARHGEF6chrX

135790929

-
intron-3CDSENST00000541606ENST00000535227DNALI1chr1

38025097

+ARHGEF6chrX

135790929

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296218DNALI1chr138023349-ENST00000370620ARHGEF6chrX135790929-4289303101806598
ENST00000296218DNALI1chr138023349-ENST00000370622ARHGEF6chrX135790929-4289303101806598
ENST00000296218DNALI1chr138023349-ENST00000250617ARHGEF6chrX135790929-4289303101806598
ENST00000296218DNALI1chr138023349-ENST00000535227ARHGEF6chrX135790929-2049303101806598

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296218ENST00000370620DNALI1chr138023349-ARHGEF6chrX135790929-0.0007784060.99922156
ENST00000296218ENST00000370622DNALI1chr138023349-ARHGEF6chrX135790929-0.0007784060.99922156
ENST00000296218ENST00000250617DNALI1chr138023349-ARHGEF6chrX135790929-0.0007784060.99922156
ENST00000296218ENST00000535227DNALI1chr138023349-ARHGEF6chrX135790929-0.0020809730.997919

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Fusion Genomic Features for DNALI1-ARHGEF6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DNALI1-ARHGEF6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:38025097/chrX:135790929)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARHGEF6

Q15052

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acts as a RAC1 guanine nucleotide exchange factor (GEF).

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARHGEF6chr1:38023349chrX:135790929ENST00000250617622443_548275777.0DomainPH
TgeneARHGEF6chr1:38023349chrX:135790929ENST00000370620521160_219121623.0DomainSH3
TgeneARHGEF6chr1:38023349chrX:135790929ENST00000370620521241_421121623.0DomainDH
TgeneARHGEF6chr1:38023349chrX:135790929ENST00000370620521443_548121623.0DomainPH
TgeneARHGEF6chr1:38023349chrX:135790929ENST00000370622521160_219121623.0DomainSH3
TgeneARHGEF6chr1:38023349chrX:135790929ENST00000370622521241_421121623.0DomainDH
TgeneARHGEF6chr1:38023349chrX:135790929ENST00000370622521443_548121623.0DomainPH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNALI1chr1:38023349chrX:135790929ENST00000296218-26176_25597281.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF6chr1:38023349chrX:135790929ENST00000250617622160_219275777.0DomainSH3
TgeneARHGEF6chr1:38023349chrX:135790929ENST000002506176221_111275777.0DomainCalponin-homology (CH)
TgeneARHGEF6chr1:38023349chrX:135790929ENST00000250617622241_421275777.0DomainDH
TgeneARHGEF6chr1:38023349chrX:135790929ENST000003706205211_111121623.0DomainCalponin-homology (CH)
TgeneARHGEF6chr1:38023349chrX:135790929ENST000003706225211_111121623.0DomainCalponin-homology (CH)


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Fusion Gene Sequence for DNALI1-ARHGEF6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>23598_23598_1_DNALI1-ARHGEF6_DNALI1_chr1_38023349_ENST00000296218_ARHGEF6_chrX_135790929_ENST00000250617_length(transcript)=4289nt_BP=303nt
GGCGGTTTCCATGGTGACGGCAAACAAGGCCCACACTGGACAGGGCAGCTGCTGGGTTGCTACTCTCGCCTCCGCCATGATTCCGCCCGC
AGACTCTTTGCTCAAGTACGACACCCCAGTGCTGGTGAGCCGGAACACGGAGAAACGGAGCCCCAAGGCTCGGCTACTGAAAGTCAGCCC
CCAGCAGCCTGGACCTTCAGGTTCAGCCCCACAGCCACCCAAGACCAAGCTCCCCTCAACTCCCTGTGTCCCAGATCCTACAAAGCAGGC
AGAAGAAATCTTGAATGCCATACTACCCCCAAGTCTGAGTACTGTGGAGGTTACATCTTTACTGGGAAACTTCGAGGAAGTATGCACATT
TCAACAGACACTCTGCCAAGCCTTGGAAGAATGTTCAAAGTTTCCAGAAAACCAGCACAAAGTAGGAGGTTGTCTACTGAGTCTCATGCC
TCATTTTAAATCTATGTATCTGGCTTACTGTGCAAACCATCCTTCAGCTGTAAATGTGCTCACTCAGCACAGTGATGAGTTGGAACAATT
CATGGAAAATCAAGGTGCATCGAGCCCAGGTATCCTCATTTTAACAACAAACCTCAGCAAACCATTCATGCGACTGGAGAAATATGTTAC
TCTCTTGCAAGAGTTAGAACGGCATATGGAGGATACTCATCCAGATCATCAGGATATTCTGAAAGCAATCGTAGCATTCAAAACTCTCAT
GGGGCAATGTCAAGATCTGAGGAAGAGAAAACAGCTGGAGTTACAGATACTGTCCGAACCTATTCAGGCATGGGAAGGAGAAGATATTAA
AAACTTGGGAAATGTGATTTTTATGTCACAAGTAATGGTGCAGTATGGAGCATGTGAGGAAAAAGAGGAGCGGTACCTTATGTTATTTTC
AAATGTCCTGATAATGTTATCTGCAAGTCCTCGGATGAGTGGCTTTATCTATCAGGGAAAAATACCAATAGCAGGAACGGTGGTGACTAG
ATTAGATGAAATTGAAGGGAATGACTGCACATTTGAAATCACTGGTAACACAGTGGAGAGAATTGTGGTCCATTGTAACAACAACCAGGA
CTTCCAGGAATGGTTGGAGCAGCTGAACAGACTGATCAGAGGACCTGCCTCTTGCAGTTCATTATCCAAAACCTCATCGTCATCATGTAG
TGCTCATTCTTCTTTTAGCTCTACCGGACAGCCCCGAGGACCCTTGGAGCCTCCTCAAATTATAAAACCGTGGAGTTTAAGTTGTCTACG
ACCTGCACCTCCACTTAGACCATCAGCAGCACTAGGTTATAAAGAGAGGATGTCTTATATCTTAAAGGAGTCTAGTAAAAGCCCTAAAAC
GATGAAGAAATTTCTTCATAAAAGGAAGACTGAGAGAAAACCATCGGAGGAGGAATATGTGATTAGGAAAAGTACAGCTGCTCTGGAAGA
GGATGCTCAAATCCTTAAAGTGATCGAAGCCTACTGCACCAGCGCAAATTTTCAACAAGGCCATGGCTCAAGTACTCGAAAAGATTCCAT
TCCACAAGTCCTACTCCCTGAGGAAGAGAAACTCATCATTGAAGAAACCAGAAGCAACGGCCAGACCATCATGGAAGAAAAGAGCCTTGT
TGATACTGTTTACGCCTTGAAGGACGAGGTCAGAGAACTGAAGCAGGAAAATAAAAGAATGAAGCAATGCCTGGAAGAAGAACTGAAATC
AAGAAGGGACCTAGAAAAGCTGGTGCGGAGGCTTTTGAAGCAAACAGATGAGTGTATTCGAGGCGAGTCCAGTAGCAAGACCTCAATTCT
TCCATAACCATCACTGTGCCACTGGGTGGAGTGTGCCTTCAGGGCATCTTGAAATGTCCCGCTGAATGATTTGACTCAGTTTGCTCACTT
CTTTGGCTTTTGTTTTGTGTTTGAGTCTCTCTCTCTCTCTCCCTCTCTCTTCTCTTTCTCTCCCCGCTGTGTGCATATGTGTGTGCGTGC
ACGTGCGCGCTTGGGCATTTGCTGTTGTTTGGTTATTGGTTGGTTGTTCATTTTTTTTTTCAACAGGTGAAAAAGCAGGAAGTGGTGGTA
GAGATGGCCTCAGAGTCTTTTCCATTCAGTAAGAAAGAGAAAGGGAATGCAGGCCAGTTACTTAAAAGGTCTTCAGATTGCCTTCAGTTC
ACAGTGCCTCTGCAACAGCCATTGCCCTCAGGTCACATTCTTTGGGCTGGCTGCCCTTGCAAAGCAGCTGGCCAAGGCTTATTAAATGTG
AACCCAACTTTTCCCCAGGGCTTTCCTGTACCTGCAAGCCTCTTAGTACTTAATTTACCGAAGGCAAATCTTCCAGACTATGGCTTGAGT
AGGATGAAAGACAAACACATCTGCCCAATGATCCAGCTGCCCTTCCTTAGACCATCACATGCCTCCCCTCAATCACAGGTTTTAAAATTA
CTGCCCTATGTTGTCTATAAGACCAAGAAAACTGTAGTACCCTTATTCCTTTTGTGTCATGTAAATTGTAACTCAGGGGGGCAGAAGCTC
TGGTCACCCACACCAACACCAAATCCATCAGCAAATTCTACTGGACAATCCTCCCTTTTAGTAGCAGAGTTGACCGCCTTTTCCCATTGC
ATGATAGGTTTCTTTCCCTCATTCTGCCTAGTGTGTAAGTTTTCTATTTCCCCAGTACTTTTAGCCAACCTTACCAAGTGGTGTGTAAAC
TAGTATGTATGTGCTTTGCTTACTTTTTAAAAAAATGTAGTTAGACTGTGAGGAGTTACTTTATGTACGTTGCATATTCAAACTGTGATG
TTTTATCCTTCAAAACAATCTGCATTAAGAAGATATTGTGCCCTACTAGACAGCTTTCATTCACTTTATTACTCTCTCATATATGCTGTG
AGAAGTTGTAATATTAATTGGCCTCTTTGGGTGGGACTCTAAGCAGTATTTGCAGAAATATGCTTCTGGTCCAACTTGTACATCCAGAAC
AAAAGGGCCCCTCTAGTAGCTGTGTGCTGGATTATTCAGGACTGATTAACTCAAGTTGCTCATTGAATCACATCATCCACTTTATCCCAG
AAACTAGAACTGTGAGAAACCAGGTTTAGAAGACAGTCACAGAACAGCACACATCCAAATTCAGCGCCATTGAAAGTTGGCCTAAGGCTC
AGTGCCACTCACCCCTCCCTCCCCAAAAGACAAGAGAAATTTGGCCAGATGGGGAAGGTCACTGGAAATTGAGGCCAAAGGGCTGATCAG
AATTGCCTTTATAATATATTTGATGGATGCCTATAAATGTGGGTTTTGCAAATATTGTTTAAAAACCAAACTTGAAGCCAGGCATGGTGG
CCCACACCTGTGGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGGATCATTTGAGCCCAGGAGGTCAAGGCTGCAGTGAGCTGTGATGACA
CCACTGCACTCCAACCTAGGTAACAGAGAGACACCTCTGTCTCTGAAAAAACAAAACTTGAAGTTTGAAACCCCCAGCTTGCTGAGGAGC
CCTTTTTATTTTTGGTACTGAGAGTCTCAAGGTCCCATAGCTACATGGTACAGGGCTGTTGTCTGCTTGCTGCACAGCAGAAATTACACC
ATCCACAGGAAATGGACTATTTTTGCAGTCCAACATCAGCCAACCACACACAGCCGTGTTTGGAAGCTGAAGAGTAAAGAAATTTCTAGG
AATGGCTGTTGTTCTGTTTTTTAGCACAGCCATTTAGATATAACATCCTTCACTTAAAAATTAAAAACATCAGTACTACCACCACCACCA
ACAACATCAACACAGATCTTCACATCTGCCCATTCTGTGGTTAGTCAATGGCTTGCAATAAATGTGCAAACTGCATCTATAGGAAACATT
TTTGTGATTACGGAATACTTTAGTTGATTGCTGAAAATATTGAAAGGTCTTCATTTTACAGTGATGAGTACATATGCATGTTTCGGGGAC
TTGGCCCTTCTGATGAGGGGCCCTCGGTACTCTGGATAACGAAGCTTGTGCAGAGTGGTAACCATGCTTACACACTAAACTATAATATAA
AGGAAATGAAGCCATGTTAATCTGAGAGCAGTGTCGCCATAGTTGTGTTGTTTACAATACTCTATAAATGGGTTCCTGTTGCCCTGTAAT
TAAACTGCTGCCCGTAGAGGCCTTTCAGTTCCTTTTCTGTCCTTCCCCTTCTTAACACAAGCTCAAATTTTCTAACTTGTTTTTATTTTG

>23598_23598_1_DNALI1-ARHGEF6_DNALI1_chr1_38023349_ENST00000296218_ARHGEF6_chrX_135790929_ENST00000250617_length(amino acids)=598AA_BP=97
MVTANKAHTGQGSCWVATLASAMIPPADSLLKYDTPVLVSRNTEKRSPKARLLKVSPQQPGPSGSAPQPPKTKLPSTPCVPDPTKQAEEI
LNAILPPSLSTVEVTSLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMEN
QGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLG
NVIFMSQVMVQYGACEEKEERYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQE
WLEQLNRLIRGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPLRPSAALGYKERMSYILKESSKSPKTMKK
FLHKRKTERKPSEEEYVIRKSTAALEEDAQILKVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDTV

--------------------------------------------------------------
>23598_23598_2_DNALI1-ARHGEF6_DNALI1_chr1_38023349_ENST00000296218_ARHGEF6_chrX_135790929_ENST00000370620_length(transcript)=4289nt_BP=303nt
GGCGGTTTCCATGGTGACGGCAAACAAGGCCCACACTGGACAGGGCAGCTGCTGGGTTGCTACTCTCGCCTCCGCCATGATTCCGCCCGC
AGACTCTTTGCTCAAGTACGACACCCCAGTGCTGGTGAGCCGGAACACGGAGAAACGGAGCCCCAAGGCTCGGCTACTGAAAGTCAGCCC
CCAGCAGCCTGGACCTTCAGGTTCAGCCCCACAGCCACCCAAGACCAAGCTCCCCTCAACTCCCTGTGTCCCAGATCCTACAAAGCAGGC
AGAAGAAATCTTGAATGCCATACTACCCCCAAGTCTGAGTACTGTGGAGGTTACATCTTTACTGGGAAACTTCGAGGAAGTATGCACATT
TCAACAGACACTCTGCCAAGCCTTGGAAGAATGTTCAAAGTTTCCAGAAAACCAGCACAAAGTAGGAGGTTGTCTACTGAGTCTCATGCC
TCATTTTAAATCTATGTATCTGGCTTACTGTGCAAACCATCCTTCAGCTGTAAATGTGCTCACTCAGCACAGTGATGAGTTGGAACAATT
CATGGAAAATCAAGGTGCATCGAGCCCAGGTATCCTCATTTTAACAACAAACCTCAGCAAACCATTCATGCGACTGGAGAAATATGTTAC
TCTCTTGCAAGAGTTAGAACGGCATATGGAGGATACTCATCCAGATCATCAGGATATTCTGAAAGCAATCGTAGCATTCAAAACTCTCAT
GGGGCAATGTCAAGATCTGAGGAAGAGAAAACAGCTGGAGTTACAGATACTGTCCGAACCTATTCAGGCATGGGAAGGAGAAGATATTAA
AAACTTGGGAAATGTGATTTTTATGTCACAAGTAATGGTGCAGTATGGAGCATGTGAGGAAAAAGAGGAGCGGTACCTTATGTTATTTTC
AAATGTCCTGATAATGTTATCTGCAAGTCCTCGGATGAGTGGCTTTATCTATCAGGGAAAAATACCAATAGCAGGAACGGTGGTGACTAG
ATTAGATGAAATTGAAGGGAATGACTGCACATTTGAAATCACTGGTAACACAGTGGAGAGAATTGTGGTCCATTGTAACAACAACCAGGA
CTTCCAGGAATGGTTGGAGCAGCTGAACAGACTGATCAGAGGACCTGCCTCTTGCAGTTCATTATCCAAAACCTCATCGTCATCATGTAG
TGCTCATTCTTCTTTTAGCTCTACCGGACAGCCCCGAGGACCCTTGGAGCCTCCTCAAATTATAAAACCGTGGAGTTTAAGTTGTCTACG
ACCTGCACCTCCACTTAGACCATCAGCAGCACTAGGTTATAAAGAGAGGATGTCTTATATCTTAAAGGAGTCTAGTAAAAGCCCTAAAAC
GATGAAGAAATTTCTTCATAAAAGGAAGACTGAGAGAAAACCATCGGAGGAGGAATATGTGATTAGGAAAAGTACAGCTGCTCTGGAAGA
GGATGCTCAAATCCTTAAAGTGATCGAAGCCTACTGCACCAGCGCAAATTTTCAACAAGGCCATGGCTCAAGTACTCGAAAAGATTCCAT
TCCACAAGTCCTACTCCCTGAGGAAGAGAAACTCATCATTGAAGAAACCAGAAGCAACGGCCAGACCATCATGGAAGAAAAGAGCCTTGT
TGATACTGTTTACGCCTTGAAGGACGAGGTCAGAGAACTGAAGCAGGAAAATAAAAGAATGAAGCAATGCCTGGAAGAAGAACTGAAATC
AAGAAGGGACCTAGAAAAGCTGGTGCGGAGGCTTTTGAAGCAAACAGATGAGTGTATTCGAGGCGAGTCCAGTAGCAAGACCTCAATTCT
TCCATAACCATCACTGTGCCACTGGGTGGAGTGTGCCTTCAGGGCATCTTGAAATGTCCCGCTGAATGATTTGACTCAGTTTGCTCACTT
CTTTGGCTTTTGTTTTGTGTTTGAGTCTCTCTCTCTCTCTCCCTCTCTCTTCTCTTTCTCTCCCCGCTGTGTGCATATGTGTGTGCGTGC
ACGTGCGCGCTTGGGCATTTGCTGTTGTTTGGTTATTGGTTGGTTGTTCATTTTTTTTTTCAACAGGTGAAAAAGCAGGAAGTGGTGGTA
GAGATGGCCTCAGAGTCTTTTCCATTCAGTAAGAAAGAGAAAGGGAATGCAGGCCAGTTACTTAAAAGGTCTTCAGATTGCCTTCAGTTC
ACAGTGCCTCTGCAACAGCCATTGCCCTCAGGTCACATTCTTTGGGCTGGCTGCCCTTGCAAAGCAGCTGGCCAAGGCTTATTAAATGTG
AACCCAACTTTTCCCCAGGGCTTTCCTGTACCTGCAAGCCTCTTAGTACTTAATTTACCGAAGGCAAATCTTCCAGACTATGGCTTGAGT
AGGATGAAAGACAAACACATCTGCCCAATGATCCAGCTGCCCTTCCTTAGACCATCACATGCCTCCCCTCAATCACAGGTTTTAAAATTA
CTGCCCTATGTTGTCTATAAGACCAAGAAAACTGTAGTACCCTTATTCCTTTTGTGTCATGTAAATTGTAACTCAGGGGGGCAGAAGCTC
TGGTCACCCACACCAACACCAAATCCATCAGCAAATTCTACTGGACAATCCTCCCTTTTAGTAGCAGAGTTGACCGCCTTTTCCCATTGC
ATGATAGGTTTCTTTCCCTCATTCTGCCTAGTGTGTAAGTTTTCTATTTCCCCAGTACTTTTAGCCAACCTTACCAAGTGGTGTGTAAAC
TAGTATGTATGTGCTTTGCTTACTTTTTAAAAAAATGTAGTTAGACTGTGAGGAGTTACTTTATGTACGTTGCATATTCAAACTGTGATG
TTTTATCCTTCAAAACAATCTGCATTAAGAAGATATTGTGCCCTACTAGACAGCTTTCATTCACTTTATTACTCTCTCATATATGCTGTG
AGAAGTTGTAATATTAATTGGCCTCTTTGGGTGGGACTCTAAGCAGTATTTGCAGAAATATGCTTCTGGTCCAACTTGTACATCCAGAAC
AAAAGGGCCCCTCTAGTAGCTGTGTGCTGGATTATTCAGGACTGATTAACTCAAGTTGCTCATTGAATCACATCATCCACTTTATCCCAG
AAACTAGAACTGTGAGAAACCAGGTTTAGAAGACAGTCACAGAACAGCACACATCCAAATTCAGCGCCATTGAAAGTTGGCCTAAGGCTC
AGTGCCACTCACCCCTCCCTCCCCAAAAGACAAGAGAAATTTGGCCAGATGGGGAAGGTCACTGGAAATTGAGGCCAAAGGGCTGATCAG
AATTGCCTTTATAATATATTTGATGGATGCCTATAAATGTGGGTTTTGCAAATATTGTTTAAAAACCAAACTTGAAGCCAGGCATGGTGG
CCCACACCTGTGGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGGATCATTTGAGCCCAGGAGGTCAAGGCTGCAGTGAGCTGTGATGACA
CCACTGCACTCCAACCTAGGTAACAGAGAGACACCTCTGTCTCTGAAAAAACAAAACTTGAAGTTTGAAACCCCCAGCTTGCTGAGGAGC
CCTTTTTATTTTTGGTACTGAGAGTCTCAAGGTCCCATAGCTACATGGTACAGGGCTGTTGTCTGCTTGCTGCACAGCAGAAATTACACC
ATCCACAGGAAATGGACTATTTTTGCAGTCCAACATCAGCCAACCACACACAGCCGTGTTTGGAAGCTGAAGAGTAAAGAAATTTCTAGG
AATGGCTGTTGTTCTGTTTTTTAGCACAGCCATTTAGATATAACATCCTTCACTTAAAAATTAAAAACATCAGTACTACCACCACCACCA
ACAACATCAACACAGATCTTCACATCTGCCCATTCTGTGGTTAGTCAATGGCTTGCAATAAATGTGCAAACTGCATCTATAGGAAACATT
TTTGTGATTACGGAATACTTTAGTTGATTGCTGAAAATATTGAAAGGTCTTCATTTTACAGTGATGAGTACATATGCATGTTTCGGGGAC
TTGGCCCTTCTGATGAGGGGCCCTCGGTACTCTGGATAACGAAGCTTGTGCAGAGTGGTAACCATGCTTACACACTAAACTATAATATAA
AGGAAATGAAGCCATGTTAATCTGAGAGCAGTGTCGCCATAGTTGTGTTGTTTACAATACTCTATAAATGGGTTCCTGTTGCCCTGTAAT
TAAACTGCTGCCCGTAGAGGCCTTTCAGTTCCTTTTCTGTCCTTCCCCTTCTTAACACAAGCTCAAATTTTCTAACTTGTTTTTATTTTG

>23598_23598_2_DNALI1-ARHGEF6_DNALI1_chr1_38023349_ENST00000296218_ARHGEF6_chrX_135790929_ENST00000370620_length(amino acids)=598AA_BP=97
MVTANKAHTGQGSCWVATLASAMIPPADSLLKYDTPVLVSRNTEKRSPKARLLKVSPQQPGPSGSAPQPPKTKLPSTPCVPDPTKQAEEI
LNAILPPSLSTVEVTSLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMEN
QGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLG
NVIFMSQVMVQYGACEEKEERYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQE
WLEQLNRLIRGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPLRPSAALGYKERMSYILKESSKSPKTMKK
FLHKRKTERKPSEEEYVIRKSTAALEEDAQILKVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDTV

--------------------------------------------------------------
>23598_23598_3_DNALI1-ARHGEF6_DNALI1_chr1_38023349_ENST00000296218_ARHGEF6_chrX_135790929_ENST00000370622_length(transcript)=4289nt_BP=303nt
GGCGGTTTCCATGGTGACGGCAAACAAGGCCCACACTGGACAGGGCAGCTGCTGGGTTGCTACTCTCGCCTCCGCCATGATTCCGCCCGC
AGACTCTTTGCTCAAGTACGACACCCCAGTGCTGGTGAGCCGGAACACGGAGAAACGGAGCCCCAAGGCTCGGCTACTGAAAGTCAGCCC
CCAGCAGCCTGGACCTTCAGGTTCAGCCCCACAGCCACCCAAGACCAAGCTCCCCTCAACTCCCTGTGTCCCAGATCCTACAAAGCAGGC
AGAAGAAATCTTGAATGCCATACTACCCCCAAGTCTGAGTACTGTGGAGGTTACATCTTTACTGGGAAACTTCGAGGAAGTATGCACATT
TCAACAGACACTCTGCCAAGCCTTGGAAGAATGTTCAAAGTTTCCAGAAAACCAGCACAAAGTAGGAGGTTGTCTACTGAGTCTCATGCC
TCATTTTAAATCTATGTATCTGGCTTACTGTGCAAACCATCCTTCAGCTGTAAATGTGCTCACTCAGCACAGTGATGAGTTGGAACAATT
CATGGAAAATCAAGGTGCATCGAGCCCAGGTATCCTCATTTTAACAACAAACCTCAGCAAACCATTCATGCGACTGGAGAAATATGTTAC
TCTCTTGCAAGAGTTAGAACGGCATATGGAGGATACTCATCCAGATCATCAGGATATTCTGAAAGCAATCGTAGCATTCAAAACTCTCAT
GGGGCAATGTCAAGATCTGAGGAAGAGAAAACAGCTGGAGTTACAGATACTGTCCGAACCTATTCAGGCATGGGAAGGAGAAGATATTAA
AAACTTGGGAAATGTGATTTTTATGTCACAAGTAATGGTGCAGTATGGAGCATGTGAGGAAAAAGAGGAGCGGTACCTTATGTTATTTTC
AAATGTCCTGATAATGTTATCTGCAAGTCCTCGGATGAGTGGCTTTATCTATCAGGGAAAAATACCAATAGCAGGAACGGTGGTGACTAG
ATTAGATGAAATTGAAGGGAATGACTGCACATTTGAAATCACTGGTAACACAGTGGAGAGAATTGTGGTCCATTGTAACAACAACCAGGA
CTTCCAGGAATGGTTGGAGCAGCTGAACAGACTGATCAGAGGACCTGCCTCTTGCAGTTCATTATCCAAAACCTCATCGTCATCATGTAG
TGCTCATTCTTCTTTTAGCTCTACCGGACAGCCCCGAGGACCCTTGGAGCCTCCTCAAATTATAAAACCGTGGAGTTTAAGTTGTCTACG
ACCTGCACCTCCACTTAGACCATCAGCAGCACTAGGTTATAAAGAGAGGATGTCTTATATCTTAAAGGAGTCTAGTAAAAGCCCTAAAAC
GATGAAGAAATTTCTTCATAAAAGGAAGACTGAGAGAAAACCATCGGAGGAGGAATATGTGATTAGGAAAAGTACAGCTGCTCTGGAAGA
GGATGCTCAAATCCTTAAAGTGATCGAAGCCTACTGCACCAGCGCAAATTTTCAACAAGGCCATGGCTCAAGTACTCGAAAAGATTCCAT
TCCACAAGTCCTACTCCCTGAGGAAGAGAAACTCATCATTGAAGAAACCAGAAGCAACGGCCAGACCATCATGGAAGAAAAGAGCCTTGT
TGATACTGTTTACGCCTTGAAGGACGAGGTCAGAGAACTGAAGCAGGAAAATAAAAGAATGAAGCAATGCCTGGAAGAAGAACTGAAATC
AAGAAGGGACCTAGAAAAGCTGGTGCGGAGGCTTTTGAAGCAAACAGATGAGTGTATTCGAGGCGAGTCCAGTAGCAAGACCTCAATTCT
TCCATAACCATCACTGTGCCACTGGGTGGAGTGTGCCTTCAGGGCATCTTGAAATGTCCCGCTGAATGATTTGACTCAGTTTGCTCACTT
CTTTGGCTTTTGTTTTGTGTTTGAGTCTCTCTCTCTCTCTCCCTCTCTCTTCTCTTTCTCTCCCCGCTGTGTGCATATGTGTGTGCGTGC
ACGTGCGCGCTTGGGCATTTGCTGTTGTTTGGTTATTGGTTGGTTGTTCATTTTTTTTTTCAACAGGTGAAAAAGCAGGAAGTGGTGGTA
GAGATGGCCTCAGAGTCTTTTCCATTCAGTAAGAAAGAGAAAGGGAATGCAGGCCAGTTACTTAAAAGGTCTTCAGATTGCCTTCAGTTC
ACAGTGCCTCTGCAACAGCCATTGCCCTCAGGTCACATTCTTTGGGCTGGCTGCCCTTGCAAAGCAGCTGGCCAAGGCTTATTAAATGTG
AACCCAACTTTTCCCCAGGGCTTTCCTGTACCTGCAAGCCTCTTAGTACTTAATTTACCGAAGGCAAATCTTCCAGACTATGGCTTGAGT
AGGATGAAAGACAAACACATCTGCCCAATGATCCAGCTGCCCTTCCTTAGACCATCACATGCCTCCCCTCAATCACAGGTTTTAAAATTA
CTGCCCTATGTTGTCTATAAGACCAAGAAAACTGTAGTACCCTTATTCCTTTTGTGTCATGTAAATTGTAACTCAGGGGGGCAGAAGCTC
TGGTCACCCACACCAACACCAAATCCATCAGCAAATTCTACTGGACAATCCTCCCTTTTAGTAGCAGAGTTGACCGCCTTTTCCCATTGC
ATGATAGGTTTCTTTCCCTCATTCTGCCTAGTGTGTAAGTTTTCTATTTCCCCAGTACTTTTAGCCAACCTTACCAAGTGGTGTGTAAAC
TAGTATGTATGTGCTTTGCTTACTTTTTAAAAAAATGTAGTTAGACTGTGAGGAGTTACTTTATGTACGTTGCATATTCAAACTGTGATG
TTTTATCCTTCAAAACAATCTGCATTAAGAAGATATTGTGCCCTACTAGACAGCTTTCATTCACTTTATTACTCTCTCATATATGCTGTG
AGAAGTTGTAATATTAATTGGCCTCTTTGGGTGGGACTCTAAGCAGTATTTGCAGAAATATGCTTCTGGTCCAACTTGTACATCCAGAAC
AAAAGGGCCCCTCTAGTAGCTGTGTGCTGGATTATTCAGGACTGATTAACTCAAGTTGCTCATTGAATCACATCATCCACTTTATCCCAG
AAACTAGAACTGTGAGAAACCAGGTTTAGAAGACAGTCACAGAACAGCACACATCCAAATTCAGCGCCATTGAAAGTTGGCCTAAGGCTC
AGTGCCACTCACCCCTCCCTCCCCAAAAGACAAGAGAAATTTGGCCAGATGGGGAAGGTCACTGGAAATTGAGGCCAAAGGGCTGATCAG
AATTGCCTTTATAATATATTTGATGGATGCCTATAAATGTGGGTTTTGCAAATATTGTTTAAAAACCAAACTTGAAGCCAGGCATGGTGG
CCCACACCTGTGGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGGATCATTTGAGCCCAGGAGGTCAAGGCTGCAGTGAGCTGTGATGACA
CCACTGCACTCCAACCTAGGTAACAGAGAGACACCTCTGTCTCTGAAAAAACAAAACTTGAAGTTTGAAACCCCCAGCTTGCTGAGGAGC
CCTTTTTATTTTTGGTACTGAGAGTCTCAAGGTCCCATAGCTACATGGTACAGGGCTGTTGTCTGCTTGCTGCACAGCAGAAATTACACC
ATCCACAGGAAATGGACTATTTTTGCAGTCCAACATCAGCCAACCACACACAGCCGTGTTTGGAAGCTGAAGAGTAAAGAAATTTCTAGG
AATGGCTGTTGTTCTGTTTTTTAGCACAGCCATTTAGATATAACATCCTTCACTTAAAAATTAAAAACATCAGTACTACCACCACCACCA
ACAACATCAACACAGATCTTCACATCTGCCCATTCTGTGGTTAGTCAATGGCTTGCAATAAATGTGCAAACTGCATCTATAGGAAACATT
TTTGTGATTACGGAATACTTTAGTTGATTGCTGAAAATATTGAAAGGTCTTCATTTTACAGTGATGAGTACATATGCATGTTTCGGGGAC
TTGGCCCTTCTGATGAGGGGCCCTCGGTACTCTGGATAACGAAGCTTGTGCAGAGTGGTAACCATGCTTACACACTAAACTATAATATAA
AGGAAATGAAGCCATGTTAATCTGAGAGCAGTGTCGCCATAGTTGTGTTGTTTACAATACTCTATAAATGGGTTCCTGTTGCCCTGTAAT
TAAACTGCTGCCCGTAGAGGCCTTTCAGTTCCTTTTCTGTCCTTCCCCTTCTTAACACAAGCTCAAATTTTCTAACTTGTTTTTATTTTG

>23598_23598_3_DNALI1-ARHGEF6_DNALI1_chr1_38023349_ENST00000296218_ARHGEF6_chrX_135790929_ENST00000370622_length(amino acids)=598AA_BP=97
MVTANKAHTGQGSCWVATLASAMIPPADSLLKYDTPVLVSRNTEKRSPKARLLKVSPQQPGPSGSAPQPPKTKLPSTPCVPDPTKQAEEI
LNAILPPSLSTVEVTSLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMEN
QGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLG
NVIFMSQVMVQYGACEEKEERYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQE
WLEQLNRLIRGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPLRPSAALGYKERMSYILKESSKSPKTMKK
FLHKRKTERKPSEEEYVIRKSTAALEEDAQILKVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDTV

--------------------------------------------------------------
>23598_23598_4_DNALI1-ARHGEF6_DNALI1_chr1_38023349_ENST00000296218_ARHGEF6_chrX_135790929_ENST00000535227_length(transcript)=2049nt_BP=303nt
GGCGGTTTCCATGGTGACGGCAAACAAGGCCCACACTGGACAGGGCAGCTGCTGGGTTGCTACTCTCGCCTCCGCCATGATTCCGCCCGC
AGACTCTTTGCTCAAGTACGACACCCCAGTGCTGGTGAGCCGGAACACGGAGAAACGGAGCCCCAAGGCTCGGCTACTGAAAGTCAGCCC
CCAGCAGCCTGGACCTTCAGGTTCAGCCCCACAGCCACCCAAGACCAAGCTCCCCTCAACTCCCTGTGTCCCAGATCCTACAAAGCAGGC
AGAAGAAATCTTGAATGCCATACTACCCCCAAGTCTGAGTACTGTGGAGGTTACATCTTTACTGGGAAACTTCGAGGAAGTATGCACATT
TCAACAGACACTCTGCCAAGCCTTGGAAGAATGTTCAAAGTTTCCAGAAAACCAGCACAAAGTAGGAGGTTGTCTACTGAGTCTCATGCC
TCATTTTAAATCTATGTATCTGGCTTACTGTGCAAACCATCCTTCAGCTGTAAATGTGCTCACTCAGCACAGTGATGAGTTGGAACAATT
CATGGAAAATCAAGGTGCATCGAGCCCAGGTATCCTCATTTTAACAACAAACCTCAGCAAACCATTCATGCGACTGGAGAAATATGTTAC
TCTCTTGCAAGAGTTAGAACGGCATATGGAGGATACTCATCCAGATCATCAGGATATTCTGAAAGCAATCGTAGCATTCAAAACTCTCAT
GGGGCAATGTCAAGATCTGAGGAAGAGAAAACAGCTGGAGTTACAGATACTGTCCGAACCTATTCAGGCATGGGAAGGAGAAGATATTAA
AAACTTGGGAAATGTGATTTTTATGTCACAAGTAATGGTGCAGTATGGAGCATGTGAGGAAAAAGAGGAGCGGTACCTTATGTTATTTTC
AAATGTCCTGATAATGTTATCTGCAAGTCCTCGGATGAGTGGCTTTATCTATCAGGGAAAAATACCAATAGCAGGAACGGTGGTGACTAG
ATTAGATGAAATTGAAGGGAATGACTGCACATTTGAAATCACTGGTAACACAGTGGAGAGAATTGTGGTCCATTGTAACAACAACCAGGA
CTTCCAGGAATGGTTGGAGCAGCTGAACAGACTGATCAGAGGACCTGCCTCTTGCAGTTCATTATCCAAAACCTCATCGTCATCATGTAG
TGCTCATTCTTCTTTTAGCTCTACCGGACAGCCCCGAGGACCCTTGGAGCCTCCTCAAATTATAAAACCGTGGAGTTTAAGTTGTCTACG
ACCTGCACCTCCACTTAGACCATCAGCAGCACTAGGTTATAAAGAGAGGATGTCTTATATCTTAAAGGAGTCTAGTAAAAGCCCTAAAAC
GATGAAGAAATTTCTTCATAAAAGGAAGACTGAGAGAAAACCATCGGAGGAGGAATATGTGATTAGGAAAAGTACAGCTGCTCTGGAAGA
GGATGCTCAAATCCTTAAAGTGATCGAAGCCTACTGCACCAGCGCAAATTTTCAACAAGGCCATGGCTCAAGTACTCGAAAAGATTCCAT
TCCACAAGTCCTACTCCCTGAGGAAGAGAAACTCATCATTGAAGAAACCAGAAGCAACGGCCAGACCATCATGGAAGAAAAGAGCCTTGT
TGATACTGTTTACGCCTTGAAGGACGAGGTCAGAGAACTGAAGCAGGAAAATAAAAGAATGAAGCAATGCCTGGAAGAAGAACTGAAATC
AAGAAGGGACCTAGAAAAGCTGGTGCGGAGGCTTTTGAAGCAAACAGATGAGTGTATTCGAGGCGAGTCCAGTAGCAAGACCTCAATTCT
TCCATAACCATCACTGTGCCACTGGGTGGAGTGTGCCTTCAGGGCATCTTGAAATGTCCCGCTGAATGATTTGACTCAGTTTGCTCACTT
CTTTGGCTTTTGTTTTGTGTTTGAGTCTCTCTCTCTCTCTCCCTCTCTCTTCTCTTTCTCTCCCCGCTGTGTGCATATGTGTGTGCGTGC

>23598_23598_4_DNALI1-ARHGEF6_DNALI1_chr1_38023349_ENST00000296218_ARHGEF6_chrX_135790929_ENST00000535227_length(amino acids)=598AA_BP=97
MVTANKAHTGQGSCWVATLASAMIPPADSLLKYDTPVLVSRNTEKRSPKARLLKVSPQQPGPSGSAPQPPKTKLPSTPCVPDPTKQAEEI
LNAILPPSLSTVEVTSLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMEN
QGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLG
NVIFMSQVMVQYGACEEKEERYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQE
WLEQLNRLIRGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPLRPSAALGYKERMSYILKESSKSPKTMKK
FLHKRKTERKPSEEEYVIRKSTAALEEDAQILKVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDTV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DNALI1-ARHGEF6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DNALI1-ARHGEF6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DNALI1-ARHGEF6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource