FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:DNASE2-CELF2 (FusionGDB2 ID:23607)

Fusion Gene Summary for DNASE2-CELF2

check button Fusion gene summary
Fusion gene informationFusion gene name: DNASE2-CELF2
Fusion gene ID: 23607
HgeneTgene
Gene symbol

DNASE2

CELF2

Gene ID

1777

10659

Gene namedeoxyribonuclease 2, lysosomalCUGBP Elav-like family member 2
SynonymsDNASE2A|DNL|DNL2BRUNOL3|CELF-2|CUG-BP2|CUGBP2|ETR-3|ETR3|NAPOR
Cytomap

19p13.13

10p14

Type of geneprotein-codingprotein-coding
Descriptiondeoxyribonuclease-2-alphaDNase II alphaDNase II, lysosomalR31240_2acid DNasedeoxyribonuclease II alphadeoxyribonuclease II, lysosomallysosomal DNase IICUGBP Elav-like family member 2CUG triplet repeat RNA-binding protein 2CUG-BP- and ETR-3-like factor 2ELAV-type RNA-binding protein 3KDM2B/CELF2 fusionRNA-binding protein BRUNOL-3bruno-like protein 3neuroblastoma apoptosis-related RNA-binding prote
Modification date2020031320200313
UniProtAcc

O00115

Q8N7Q2

Ensembl transtripts involved in fusion geneENST00000222219, ENST00000538460, 
ENST00000315874, ENST00000354440, 
ENST00000354897, ENST00000379261, 
ENST00000399850, ENST00000416382, 
ENST00000417956, ENST00000427450, 
ENST00000450189, ENST00000537122, 
ENST00000542579, ENST00000608830, 
ENST00000609692, 
Fusion gene scores* DoF score7 X 9 X 3=18914 X 15 X 3=630
# samples 915
** MAII scorelog2(9/189*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/630*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNASE2 [Title/Abstract] AND CELF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNASE2(12986191)-CELF2(10664581), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCELF2

GO:0006376

mRNA splice site selection

11158314


check buttonFusion gene breakpoints across DNASE2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CELF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACF123276DNASE2chr19

12986191

-CELF2chr10

10664581

+


Top

Fusion Gene ORF analysis for DNASE2-CELF2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000222219ENST00000315874DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000222219ENST00000354440DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000222219ENST00000354897DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000222219ENST00000379261DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000222219ENST00000399850DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000222219ENST00000416382DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000222219ENST00000417956DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000222219ENST00000427450DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000222219ENST00000450189DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000222219ENST00000537122DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000222219ENST00000542579DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000222219ENST00000608830DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000222219ENST00000609692DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000538460ENST00000315874DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000538460ENST00000354440DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000538460ENST00000354897DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000538460ENST00000379261DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000538460ENST00000399850DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000538460ENST00000416382DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000538460ENST00000417956DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000538460ENST00000427450DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000538460ENST00000450189DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000538460ENST00000537122DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000538460ENST00000542579DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000538460ENST00000608830DNASE2chr19

12986191

-CELF2chr10

10664581

+
intron-intronENST00000538460ENST00000609692DNASE2chr19

12986191

-CELF2chr10

10664581

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for DNASE2-CELF2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for DNASE2-CELF2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:12986191/:10664581)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNASE2

O00115

CELF2

Q8N7Q2

FUNCTION: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for DNASE2-CELF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for DNASE2-CELF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DNASE2-CELF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for DNASE2-CELF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource