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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DNM1-FGFR2 (FusionGDB2 ID:23618)

Fusion Gene Summary for DNM1-FGFR2

check button Fusion gene summary
Fusion gene informationFusion gene name: DNM1-FGFR2
Fusion gene ID: 23618
HgeneTgene
Gene symbol

DNM1

FGFR2

Gene ID

1759

2263

Gene namedynamin 1fibroblast growth factor receptor 2
SynonymsDNM|EIEE31BBDS|BEK|BFR-1|CD332|CEK3|CFD1|ECT1|JWS|K-SAM|KGFR|TK14|TK25
Cytomap

9q34.11

10q26.13

Type of geneprotein-codingprotein-coding
Descriptiondynamin-1fibroblast growth factor receptor 2BEK fibroblast growth factor receptorbacteria-expressed kinasekeratinocyte growth factor receptorprotein tyrosine kinase, receptor like 14
Modification date2020032720200322
UniProtAcc

Q05193

P21802

Ensembl transtripts involved in fusion geneENST00000341179, ENST00000372923, 
ENST00000393594, ENST00000475805, 
ENST00000486160, ENST00000493925, 
ENST00000369061, ENST00000346997, 
ENST00000351936, ENST00000356226, 
ENST00000357555, ENST00000358487, 
ENST00000359354, ENST00000360144, 
ENST00000369056, ENST00000369059, 
ENST00000369060, ENST00000457416, 
ENST00000478859, ENST00000490349, 
Fusion gene scores* DoF score3 X 3 X 3=2711 X 11 X 8=968
# samples 416
** MAII scorelog2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(16/968*10)=-2.59693514238723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNM1 [Title/Abstract] AND FGFR2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNM1(130954059)-FGFR2(123239535), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFGFR2

GO:0008284

positive regulation of cell proliferation

8663044

TgeneFGFR2

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044|15629145

TgeneFGFR2

GO:0018108

peptidyl-tyrosine phosphorylation

15629145|16844695

TgeneFGFR2

GO:0046777

protein autophosphorylation

15629145


check buttonFusion gene breakpoints across DNM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FGFR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CHOLTCGA-W5-AA2Z-01ADNM1chr9

130954059

+FGFR2chr10

123239535

-


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Fusion Gene ORF analysis for DNM1-FGFR2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000341179ENST00000369061DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-3CDSENST00000372923ENST00000369061DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-3CDSENST00000393594ENST00000369061DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-3CDSENST00000475805ENST00000369061DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-3CDSENST00000486160ENST00000369061DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-3CDSENST00000493925ENST00000369061DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000346997DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000351936DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000356226DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000357555DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000358487DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000359354DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000360144DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000369056DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000369059DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000369060DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000457416DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000478859DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000490349DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000346997DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000351936DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000356226DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000357555DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000358487DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000359354DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000360144DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000369056DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000369059DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000369060DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000457416DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000478859DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000490349DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000346997DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000351936DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000356226DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000357555DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000358487DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000359354DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000360144DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000369056DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000369059DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000369060DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000457416DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000478859DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000490349DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000346997DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000351936DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000356226DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000357555DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000358487DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000359354DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000360144DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000369056DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000369059DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000369060DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000457416DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000478859DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000490349DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000346997DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000351936DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000356226DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000357555DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000358487DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000359354DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000360144DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000369056DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000369059DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000369060DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000457416DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000478859DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000490349DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000346997DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000351936DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000356226DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000357555DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000358487DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000359354DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000360144DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000369056DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000369059DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000369060DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000457416DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000478859DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000490349DNM1chr9

130954059

+FGFR2chr10

123239535

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DNM1-FGFR2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DNM1-FGFR2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:130954059/:123239535)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNM1

Q05193

FGFR2

P21802

FUNCTION: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DNM1-FGFR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DNM1-FGFR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DNM1-FGFR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DNM1-FGFR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource