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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DNM1-LCN2 (FusionGDB2 ID:23622)

Fusion Gene Summary for DNM1-LCN2

check button Fusion gene summary
Fusion gene informationFusion gene name: DNM1-LCN2
Fusion gene ID: 23622
HgeneTgene
Gene symbol

DNM1

LCN2

Gene ID

1759

3934

Gene namedynamin 1lipocalin 2
SynonymsDNM|EIEE3124p3|MSFI|NGAL|p25
Cytomap

9q34.11

9q34.11

Type of geneprotein-codingprotein-coding
Descriptiondynamin-1neutrophil gelatinase-associated lipocalin25 kDa alpha-2-microglobulin-related subunit of MMP-9migration-stimulating factor inhibitoroncogene 24p3siderocalin LCN2
Modification date2020032720200329
UniProtAcc

Q05193

P80188

Ensembl transtripts involved in fusion geneENST00000341179, ENST00000372923, 
ENST00000393594, ENST00000475805, 
ENST00000486160, ENST00000493925, 
ENST00000277480, ENST00000372998, 
ENST00000373013, ENST00000470902, 
ENST00000540948, ENST00000373017, 
Fusion gene scores* DoF score3 X 3 X 3=2711 X 10 X 5=550
# samples 412
** MAII scorelog2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(12/550*10)=-2.1963972128035
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNM1 [Title/Abstract] AND LCN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNM1(130965910)-LCN2(130913917), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLCN2

GO:0042742

defense response to bacterium

27780864

TgeneLCN2

GO:0097577

sequestering of iron ion

27780864


check buttonFusion gene breakpoints across DNM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LCN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CN-4723-01ADNM1chr9

130965910

-LCN2chr9

130913917

+
ChimerDB4HNSCTCGA-CN-4723-01ADNM1chr9

130965910

+LCN2chr9

130913917

+
ChimerDB4HNSCTCGA-CN-4723DNM1chr9

130965910

+LCN2chr9

130913916

+
ChimerDB4HNSCTCGA-CN-4723DNM1chr9

130965910

+LCN2chr9

130913917

+


Top

Fusion Gene ORF analysis for DNM1-LCN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000341179ENST00000277480DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000341179ENST00000277480DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-3UTRENST00000341179ENST00000372998DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000341179ENST00000373013DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000341179ENST00000373013DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-3UTRENST00000341179ENST00000470902DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000341179ENST00000470902DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-3UTRENST00000341179ENST00000540948DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000341179ENST00000540948DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-3UTRENST00000372923ENST00000277480DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000372923ENST00000277480DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-3UTRENST00000372923ENST00000372998DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000372923ENST00000373013DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000372923ENST00000373013DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-3UTRENST00000372923ENST00000470902DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000372923ENST00000470902DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-3UTRENST00000372923ENST00000540948DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000372923ENST00000540948DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-3UTRENST00000393594ENST00000277480DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000393594ENST00000277480DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-3UTRENST00000393594ENST00000372998DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000393594ENST00000373013DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000393594ENST00000373013DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-3UTRENST00000393594ENST00000470902DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000393594ENST00000470902DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-3UTRENST00000393594ENST00000540948DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000393594ENST00000540948DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-3UTRENST00000475805ENST00000277480DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000475805ENST00000277480DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-3UTRENST00000475805ENST00000372998DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000475805ENST00000373013DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000475805ENST00000373013DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-3UTRENST00000475805ENST00000470902DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000475805ENST00000470902DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-3UTRENST00000475805ENST00000540948DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000475805ENST00000540948DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-3UTRENST00000486160ENST00000277480DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000486160ENST00000277480DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-3UTRENST00000486160ENST00000372998DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000486160ENST00000373013DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000486160ENST00000373013DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-3UTRENST00000486160ENST00000470902DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000486160ENST00000470902DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-3UTRENST00000486160ENST00000540948DNM1chr9

130965910

+LCN2chr9

130913917

+
5CDS-3UTRENST00000486160ENST00000540948DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-intronENST00000341179ENST00000372998DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-intronENST00000372923ENST00000372998DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-intronENST00000393594ENST00000372998DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-intronENST00000475805ENST00000372998DNM1chr9

130965910

+LCN2chr9

130913916

+
5CDS-intronENST00000486160ENST00000372998DNM1chr9

130965910

+LCN2chr9

130913916

+
In-frameENST00000341179ENST00000373017DNM1chr9

130965910

+LCN2chr9

130913917

+
In-frameENST00000341179ENST00000373017DNM1chr9

130965910

+LCN2chr9

130913916

+
In-frameENST00000372923ENST00000373017DNM1chr9

130965910

+LCN2chr9

130913917

+
In-frameENST00000372923ENST00000373017DNM1chr9

130965910

+LCN2chr9

130913916

+
In-frameENST00000393594ENST00000373017DNM1chr9

130965910

+LCN2chr9

130913917

+
In-frameENST00000393594ENST00000373017DNM1chr9

130965910

+LCN2chr9

130913916

+
In-frameENST00000475805ENST00000373017DNM1chr9

130965910

+LCN2chr9

130913917

+
In-frameENST00000475805ENST00000373017DNM1chr9

130965910

+LCN2chr9

130913916

+
In-frameENST00000486160ENST00000373017DNM1chr9

130965910

+LCN2chr9

130913917

+
In-frameENST00000486160ENST00000373017DNM1chr9

130965910

+LCN2chr9

130913916

+
intron-3CDSENST00000493925ENST00000373017DNM1chr9

130965910

+LCN2chr9

130913917

+
intron-3CDSENST00000493925ENST00000373017DNM1chr9

130965910

+LCN2chr9

130913916

+
intron-3UTRENST00000493925ENST00000277480DNM1chr9

130965910

+LCN2chr9

130913917

+
intron-3UTRENST00000493925ENST00000277480DNM1chr9

130965910

+LCN2chr9

130913916

+
intron-3UTRENST00000493925ENST00000372998DNM1chr9

130965910

+LCN2chr9

130913917

+
intron-3UTRENST00000493925ENST00000373013DNM1chr9

130965910

+LCN2chr9

130913917

+
intron-3UTRENST00000493925ENST00000373013DNM1chr9

130965910

+LCN2chr9

130913916

+
intron-3UTRENST00000493925ENST00000470902DNM1chr9

130965910

+LCN2chr9

130913917

+
intron-3UTRENST00000493925ENST00000470902DNM1chr9

130965910

+LCN2chr9

130913916

+
intron-3UTRENST00000493925ENST00000540948DNM1chr9

130965910

+LCN2chr9

130913917

+
intron-3UTRENST00000493925ENST00000540948DNM1chr9

130965910

+LCN2chr9

130913916

+
intron-intronENST00000493925ENST00000372998DNM1chr9

130965910

+LCN2chr9

130913916

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for DNM1-LCN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DNM1chr9130965910+LCN2chr9130913916+0.0003591460.9996408
DNM1chr9130965910+LCN2chr9130913923+0.0002694390.9997305
DNM1chr9130965910+LCN2chr9130913923+0.0002694390.9997305
DNM1chr9130965910+LCN2chr9130913916+0.0003591460.9996408
DNM1chr9130965910+LCN2chr9130913923+0.0002694390.9997305
DNM1chr9130965910+LCN2chr9130913923+0.0002694390.9997305

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for DNM1-LCN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:130965910/chr9:130913917)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNM1

Q05193

LCN2

P80188

FUNCTION: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.FUNCTION: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413, PubMed:27780864, PubMed:20581821). Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed:27780864). Can also bind siderophores from M.tuberculosis (PubMed:15642259, PubMed:21978368). {ECO:0000250|UniProtKB:P11672, ECO:0000269|PubMed:12453413, ECO:0000269|PubMed:15642259, ECO:0000269|PubMed:20581821, ECO:0000269|PubMed:21978368, ECO:0000269|PubMed:27780864}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNM1chr9:130965910chr9:130913916ENST00000341179+12338_4553962.3333333333334RegionG1 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000372923+12238_4553865.0RegionG1 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000393594+12338_4553975.6666666666666RegionG1 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000475805+12338_4553819.0RegionG1 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000486160+12238_4553865.0RegionG1 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000341179+12338_4553962.3333333333334RegionG1 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000372923+12238_4553865.0RegionG1 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000393594+12338_4553975.6666666666666RegionG1 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000475805+12338_4553819.0RegionG1 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000486160+12238_4553865.0RegionG1 motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNM1chr9:130965910chr9:130913916ENST00000341179+12328_29453962.3333333333334DomainDynamin-type G
HgeneDNM1chr9:130965910chr9:130913916ENST00000341179+123519_62553962.3333333333334DomainPH
HgeneDNM1chr9:130965910chr9:130913916ENST00000341179+123659_75053962.3333333333334DomainGED
HgeneDNM1chr9:130965910chr9:130913916ENST00000372923+12228_29453865.0DomainDynamin-type G
HgeneDNM1chr9:130965910chr9:130913916ENST00000372923+122519_62553865.0DomainPH
HgeneDNM1chr9:130965910chr9:130913916ENST00000372923+122659_75053865.0DomainGED
HgeneDNM1chr9:130965910chr9:130913916ENST00000393594+12328_29453975.6666666666666DomainDynamin-type G
HgeneDNM1chr9:130965910chr9:130913916ENST00000393594+123519_62553975.6666666666666DomainPH
HgeneDNM1chr9:130965910chr9:130913916ENST00000393594+123659_75053975.6666666666666DomainGED
HgeneDNM1chr9:130965910chr9:130913916ENST00000475805+12328_29453819.0DomainDynamin-type G
HgeneDNM1chr9:130965910chr9:130913916ENST00000475805+123519_62553819.0DomainPH
HgeneDNM1chr9:130965910chr9:130913916ENST00000475805+123659_75053819.0DomainGED
HgeneDNM1chr9:130965910chr9:130913916ENST00000486160+12228_29453865.0DomainDynamin-type G
HgeneDNM1chr9:130965910chr9:130913916ENST00000486160+122519_62553865.0DomainPH
HgeneDNM1chr9:130965910chr9:130913916ENST00000486160+122659_75053865.0DomainGED
HgeneDNM1chr9:130965910chr9:130913917ENST00000341179+12328_29453962.3333333333334DomainDynamin-type G
HgeneDNM1chr9:130965910chr9:130913917ENST00000341179+123519_62553962.3333333333334DomainPH
HgeneDNM1chr9:130965910chr9:130913917ENST00000341179+123659_75053962.3333333333334DomainGED
HgeneDNM1chr9:130965910chr9:130913917ENST00000372923+12228_29453865.0DomainDynamin-type G
HgeneDNM1chr9:130965910chr9:130913917ENST00000372923+122519_62553865.0DomainPH
HgeneDNM1chr9:130965910chr9:130913917ENST00000372923+122659_75053865.0DomainGED
HgeneDNM1chr9:130965910chr9:130913917ENST00000393594+12328_29453975.6666666666666DomainDynamin-type G
HgeneDNM1chr9:130965910chr9:130913917ENST00000393594+123519_62553975.6666666666666DomainPH
HgeneDNM1chr9:130965910chr9:130913917ENST00000393594+123659_75053975.6666666666666DomainGED
HgeneDNM1chr9:130965910chr9:130913917ENST00000475805+12328_29453819.0DomainDynamin-type G
HgeneDNM1chr9:130965910chr9:130913917ENST00000475805+123519_62553819.0DomainPH
HgeneDNM1chr9:130965910chr9:130913917ENST00000475805+123659_75053819.0DomainGED
HgeneDNM1chr9:130965910chr9:130913917ENST00000486160+12228_29453865.0DomainDynamin-type G
HgeneDNM1chr9:130965910chr9:130913917ENST00000486160+122519_62553865.0DomainPH
HgeneDNM1chr9:130965910chr9:130913917ENST00000486160+122659_75053865.0DomainGED
HgeneDNM1chr9:130965910chr9:130913916ENST00000341179+123136_14053962.3333333333334Nucleotide bindingGTP
HgeneDNM1chr9:130965910chr9:130913916ENST00000372923+122136_14053865.0Nucleotide bindingGTP
HgeneDNM1chr9:130965910chr9:130913916ENST00000393594+123136_14053975.6666666666666Nucleotide bindingGTP
HgeneDNM1chr9:130965910chr9:130913916ENST00000475805+123136_14053819.0Nucleotide bindingGTP
HgeneDNM1chr9:130965910chr9:130913916ENST00000486160+122136_14053865.0Nucleotide bindingGTP
HgeneDNM1chr9:130965910chr9:130913917ENST00000341179+123136_14053962.3333333333334Nucleotide bindingGTP
HgeneDNM1chr9:130965910chr9:130913917ENST00000372923+122136_14053865.0Nucleotide bindingGTP
HgeneDNM1chr9:130965910chr9:130913917ENST00000393594+123136_14053975.6666666666666Nucleotide bindingGTP
HgeneDNM1chr9:130965910chr9:130913917ENST00000475805+123136_14053819.0Nucleotide bindingGTP
HgeneDNM1chr9:130965910chr9:130913917ENST00000486160+122136_14053865.0Nucleotide bindingGTP
HgeneDNM1chr9:130965910chr9:130913916ENST00000341179+123136_13953962.3333333333334RegionG3 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000341179+123205_20853962.3333333333334RegionG4 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000341179+123235_23853962.3333333333334RegionG5 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000341179+12364_6653962.3333333333334RegionG2 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000372923+122136_13953865.0RegionG3 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000372923+122205_20853865.0RegionG4 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000372923+122235_23853865.0RegionG5 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000372923+12264_6653865.0RegionG2 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000393594+123136_13953975.6666666666666RegionG3 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000393594+123205_20853975.6666666666666RegionG4 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000393594+123235_23853975.6666666666666RegionG5 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000393594+12364_6653975.6666666666666RegionG2 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000475805+123136_13953819.0RegionG3 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000475805+123205_20853819.0RegionG4 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000475805+123235_23853819.0RegionG5 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000475805+12364_6653819.0RegionG2 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000486160+122136_13953865.0RegionG3 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000486160+122205_20853865.0RegionG4 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000486160+122235_23853865.0RegionG5 motif
HgeneDNM1chr9:130965910chr9:130913916ENST00000486160+12264_6653865.0RegionG2 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000341179+123136_13953962.3333333333334RegionG3 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000341179+123205_20853962.3333333333334RegionG4 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000341179+123235_23853962.3333333333334RegionG5 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000341179+12364_6653962.3333333333334RegionG2 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000372923+122136_13953865.0RegionG3 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000372923+122205_20853865.0RegionG4 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000372923+122235_23853865.0RegionG5 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000372923+12264_6653865.0RegionG2 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000393594+123136_13953975.6666666666666RegionG3 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000393594+123205_20853975.6666666666666RegionG4 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000393594+123235_23853975.6666666666666RegionG5 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000393594+12364_6653975.6666666666666RegionG2 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000475805+123136_13953819.0RegionG3 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000475805+123205_20853819.0RegionG4 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000475805+123235_23853819.0RegionG5 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000475805+12364_6653819.0RegionG2 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000486160+122136_13953865.0RegionG3 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000486160+122205_20853865.0RegionG4 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000486160+122235_23853865.0RegionG5 motif
HgeneDNM1chr9:130965910chr9:130913917ENST00000486160+12264_6653865.0RegionG2 motif
TgeneLCN2chr9:130965910chr9:130913916ENST000002774801772_7491177.0RegionCarboxymycobactin binding
TgeneLCN2chr9:130965910chr9:130913916ENST000003730172772_7491199.0RegionCarboxymycobactin binding
TgeneLCN2chr9:130965910chr9:130913916ENST000005409481572_7491199.0RegionCarboxymycobactin binding
TgeneLCN2chr9:130965910chr9:130913917ENST000002774801772_7491177.0RegionCarboxymycobactin binding
TgeneLCN2chr9:130965910chr9:130913917ENST000003730172772_7491199.0RegionCarboxymycobactin binding
TgeneLCN2chr9:130965910chr9:130913917ENST000005409481572_7491199.0RegionCarboxymycobactin binding


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Fusion Gene Sequence for DNM1-LCN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DNM1-LCN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DNM1-LCN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DNM1-LCN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource