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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DNM1L-TSPAN11 (FusionGDB2 ID:23627)

Fusion Gene Summary for DNM1L-TSPAN11

check button Fusion gene summary
Fusion gene informationFusion gene name: DNM1L-TSPAN11
Fusion gene ID: 23627
HgeneTgene
Gene symbol

DNM1L

TSPAN11

Gene ID

10059

441631

Gene namedynamin 1 liketetraspanin 11
SynonymsDLP1|DRP1|DVLP|DYMPLE|EMPF|EMPF1|HDYNIV|OPA5VSSW1971
Cytomap

12p11.21

12p11.21

Type of geneprotein-codingprotein-coding
Descriptiondynamin-1-like proteinDnm1p/Vps1p-like proteindynamin family member proline-rich carboxyl-terminal domain lessdynamin-like protein 4dynamin-like protein IVdynamin-related protein 1tetraspanin-11tspan-11
Modification date2020032720200313
UniProtAcc

O00429

.
Ensembl transtripts involved in fusion geneENST00000548671, ENST00000266481, 
ENST00000358214, ENST00000381000, 
ENST00000452533, ENST00000547312, 
ENST00000549701, ENST00000553257, 
ENST00000414834, 		ENST00000261177, 
ENST00000545802, ENST00000546076, 
ENST00000535215, ENST00000544427, 
Fusion gene scores* DoF score8 X 4 X 9=2886 X 4 X 5=120
# samples 106
** MAII scorelog2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNM1L [Title/Abstract] AND TSPAN11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNM1L(32832399)-TSPAN11(31106915), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNM1L

GO:0000266

mitochondrial fission

23530241

HgeneDNM1L

GO:0003374

dynamin family protein polymerization involved in mitochondrial fission

11514614|23530241

HgeneDNM1L

GO:0016559

peroxisome fission

12618434

HgeneDNM1L

GO:0050714

positive regulation of protein secretion

9570752

HgeneDNM1L

GO:0061025

membrane fusion

20850011

HgeneDNM1L

GO:0065003

protein-containing complex assembly

20850011

HgeneDNM1L

GO:0090149

mitochondrial membrane fission

11514614


check buttonFusion gene breakpoints across DNM1L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TSPAN11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-D5-6929-01ADNM1Lchr12

32832399

-TSPAN11chr12

31106915

+
ChimerDB4COADTCGA-D5-6929-01ADNM1Lchr12

32832399

+TSPAN11chr12

31106915

+


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Fusion Gene ORF analysis for DNM1L-TSPAN11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000548671ENST00000261177DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
3UTR-5UTRENST00000548671ENST00000545802DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
3UTR-5UTRENST00000548671ENST00000546076DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
3UTR-intronENST00000548671ENST00000535215DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
3UTR-intronENST00000548671ENST00000544427DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-5UTRENST00000266481ENST00000261177DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-5UTRENST00000266481ENST00000545802DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-5UTRENST00000266481ENST00000546076DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-5UTRENST00000358214ENST00000261177DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-5UTRENST00000358214ENST00000545802DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-5UTRENST00000358214ENST00000546076DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-5UTRENST00000381000ENST00000261177DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-5UTRENST00000381000ENST00000545802DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-5UTRENST00000381000ENST00000546076DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-5UTRENST00000452533ENST00000261177DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-5UTRENST00000452533ENST00000545802DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-5UTRENST00000452533ENST00000546076DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-5UTRENST00000547312ENST00000261177DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-5UTRENST00000547312ENST00000545802DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-5UTRENST00000547312ENST00000546076DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-5UTRENST00000549701ENST00000261177DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-5UTRENST00000549701ENST00000545802DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-5UTRENST00000549701ENST00000546076DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-5UTRENST00000553257ENST00000261177DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-5UTRENST00000553257ENST00000545802DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-5UTRENST00000553257ENST00000546076DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-intronENST00000266481ENST00000535215DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-intronENST00000266481ENST00000544427DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-intronENST00000358214ENST00000535215DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-intronENST00000358214ENST00000544427DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-intronENST00000381000ENST00000535215DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-intronENST00000381000ENST00000544427DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-intronENST00000452533ENST00000535215DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-intronENST00000452533ENST00000544427DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-intronENST00000547312ENST00000535215DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-intronENST00000547312ENST00000544427DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-intronENST00000549701ENST00000535215DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-intronENST00000549701ENST00000544427DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-intronENST00000553257ENST00000535215DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5CDS-intronENST00000553257ENST00000544427DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5UTR-5UTRENST00000414834ENST00000261177DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5UTR-5UTRENST00000414834ENST00000545802DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5UTR-5UTRENST00000414834ENST00000546076DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5UTR-intronENST00000414834ENST00000535215DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+
5UTR-intronENST00000414834ENST00000544427DNM1Lchr12

32832399

+TSPAN11chr12

31106915

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DNM1L-TSPAN11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DNM1Lchr1232832399+TSPAN11chr1231106914+1.03E-101
DNM1Lchr1232832399+TSPAN11chr1231106914+1.03E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DNM1L-TSPAN11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:32832399/:31106915)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNM1L

O00429

.
FUNCTION: Functions in mitochondrial and peroxisomal division (PubMed:9570752, PubMed:9786947, PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17553808, PubMed:17460227, PubMed:18695047, PubMed:18838687, PubMed:19638400, PubMed:19411255, PubMed:19342591, PubMed:23921378, PubMed:23283981, PubMed:23530241, PubMed:29478834, PubMed:32484300, PubMed:27145208, PubMed:26992161, PubMed:27301544, PubMed:27328748). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23921378, PubMed:23283981, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:27145208, PubMed:26992161, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:9570752, PubMed:20688057, PubMed:23792689). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:11514614, ECO:0000269|PubMed:12499366, ECO:0000269|PubMed:17015472, ECO:0000269|PubMed:17301055, ECO:0000269|PubMed:17460227, ECO:0000269|PubMed:17553808, ECO:0000269|PubMed:18695047, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19342591, ECO:0000269|PubMed:19411255, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:20688057, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23584531, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:26992161, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:27301544, ECO:0000269|PubMed:27328748, ECO:0000269|PubMed:29478834, ECO:0000269|PubMed:29899447, ECO:0000269|PubMed:32484300, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DNM1L-TSPAN11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DNM1L-TSPAN11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DNM1L-TSPAN11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DNM1L-TSPAN11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource