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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DNM2-ANGPTL4 (FusionGDB2 ID:23631)

Fusion Gene Summary for DNM2-ANGPTL4

check button Fusion gene summary
Fusion gene informationFusion gene name: DNM2-ANGPTL4
Fusion gene ID: 23631
HgeneTgene
Gene symbol

DNM2

ANGPTL4

Gene ID

1785

51129

Gene namedynamin 2angiopoietin like 4
SynonymsCMT2M|CMTDI1|CMTDIB|DI-CMTB|DYN2|DYNII|LCCS5ARP4|FIAF|HARP|HFARP|NL2|PGAR|TGQTL|UNQ171|pp1158
Cytomap

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptiondynamin-2dynamin IIangiopoietin-related protein 4PPARG angiopoietin related proteinfasting-induced adipose factorhepatic angiopoietin-related proteinhepatic fibrinogen/angiopoietin-related proteinperoxisome proliferator-activated receptor (PPAR) gamma induced angiopoie
Modification date2020032920200322
UniProtAcc

P50570

Q9BY76

Ensembl transtripts involved in fusion geneENST00000314646, ENST00000355667, 
ENST00000359692, ENST00000389253, 
ENST00000408974, ENST00000585892, 
ENST00000591819, 		ENST00000541807, 
ENST00000301455, ENST00000393962, 
Fusion gene scores* DoF score36 X 17 X 17=104044 X 4 X 3=48
# samples 496
** MAII scorelog2(49/10404*10)=-4.40821274494042
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DNM2 [Title/Abstract] AND ANGPTL4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNM2(10829079)-ANGPTL4(8438589), # samples:3
Anticipated loss of major functional domain due to fusion event.DNM2-ANGPTL4 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
DNM2-ANGPTL4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DNM2-ANGPTL4 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
DNM2-ANGPTL4 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNM2

GO:1903526

negative regulation of membrane tubulation

18388313

TgeneANGPTL4

GO:0043066

negative regulation of apoptotic process

10698685

TgeneANGPTL4

GO:0043335

protein unfolding

29899144

TgeneANGPTL4

GO:0051005

negative regulation of lipoprotein lipase activity

19542565|29899144


check buttonFusion gene breakpoints across DNM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANGPTL4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-KR-A7K8-01ADNM2chr19

10829079

-ANGPTL4chr19

8438589

+
ChimerDB4LIHCTCGA-KR-A7K8-01ADNM2chr19

10829079

+ANGPTL4chr19

8438589

+


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Fusion Gene ORF analysis for DNM2-ANGPTL4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000314646ENST00000541807DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
Frame-shiftENST00000355667ENST00000541807DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
Frame-shiftENST00000359692ENST00000541807DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
Frame-shiftENST00000389253ENST00000541807DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
Frame-shiftENST00000408974ENST00000541807DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
Frame-shiftENST00000585892ENST00000541807DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000314646ENST00000301455DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000314646ENST00000393962DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000355667ENST00000301455DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000355667ENST00000393962DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000359692ENST00000301455DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000359692ENST00000393962DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000389253ENST00000301455DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000389253ENST00000393962DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000408974ENST00000301455DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000408974ENST00000393962DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000585892ENST00000301455DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
In-frameENST00000585892ENST00000393962DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
intron-3CDSENST00000591819ENST00000301455DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
intron-3CDSENST00000591819ENST00000393962DNM2chr19

10829079

+ANGPTL4chr19

8438589

+
intron-3CDSENST00000591819ENST00000541807DNM2chr19

10829079

+ANGPTL4chr19

8438589

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000585892DNM2chr1910829079+ENST00000301455ANGPTL4chr198438589+994325722222166
ENST00000585892DNM2chr1910829079+ENST00000393962ANGPTL4chr198438589+952325722222166
ENST00000314646DNM2chr1910829079+ENST00000301455ANGPTL4chr198438589+994325722222166
ENST00000314646DNM2chr1910829079+ENST00000393962ANGPTL4chr198438589+952325722222166
ENST00000359692DNM2chr1910829079+ENST00000301455ANGPTL4chr198438589+980311708208166
ENST00000359692DNM2chr1910829079+ENST00000393962ANGPTL4chr198438589+938311708208166
ENST00000389253DNM2chr1910829079+ENST00000301455ANGPTL4chr198438589+942273670170166
ENST00000389253DNM2chr1910829079+ENST00000393962ANGPTL4chr198438589+900273670170166
ENST00000355667DNM2chr1910829079+ENST00000301455ANGPTL4chr198438589+910241638138166
ENST00000355667DNM2chr1910829079+ENST00000393962ANGPTL4chr198438589+868241638138166
ENST00000408974DNM2chr1910829079+ENST00000301455ANGPTL4chr198438589+86519659393166
ENST00000408974DNM2chr1910829079+ENST00000393962ANGPTL4chr198438589+82319659393166

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000585892ENST00000301455DNM2chr1910829079+ANGPTL4chr198438589+0.093919310.90608066
ENST00000585892ENST00000393962DNM2chr1910829079+ANGPTL4chr198438589+0.08592720.9140728
ENST00000314646ENST00000301455DNM2chr1910829079+ANGPTL4chr198438589+0.093919310.90608066
ENST00000314646ENST00000393962DNM2chr1910829079+ANGPTL4chr198438589+0.08592720.9140728
ENST00000359692ENST00000301455DNM2chr1910829079+ANGPTL4chr198438589+0.093265650.9067343
ENST00000359692ENST00000393962DNM2chr1910829079+ANGPTL4chr198438589+0.0887280850.9112719
ENST00000389253ENST00000301455DNM2chr1910829079+ANGPTL4chr198438589+0.130651650.86934835
ENST00000389253ENST00000393962DNM2chr1910829079+ANGPTL4chr198438589+0.106396910.8936031
ENST00000355667ENST00000301455DNM2chr1910829079+ANGPTL4chr198438589+0.0658499750.93415
ENST00000355667ENST00000393962DNM2chr1910829079+ANGPTL4chr198438589+0.071436590.92856336
ENST00000408974ENST00000301455DNM2chr1910829079+ANGPTL4chr198438589+0.122914170.8770858
ENST00000408974ENST00000393962DNM2chr1910829079+ANGPTL4chr198438589+0.126748870.8732511

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Fusion Genomic Features for DNM2-ANGPTL4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DNM2chr1910829079+ANGPTL4chr198438588+1.35E-101
DNM2chr1910829079+ANGPTL4chr198438588+1.35E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DNM2-ANGPTL4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:10829079/chr19:8438589)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNM2

P50570

ANGPTL4

Q9BY76

FUNCTION: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis (PubMed:12498685). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:12498685}.FUNCTION: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism (PubMed:19270337, PubMed:21398697, PubMed:27929370, PubMed:29899144). May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (PubMed:14583458, PubMed:17068295). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (PubMed:17068295). Depending on context, may modulate tumor-related angiogenesis (By similarity). {ECO:0000250|UniProtKB:Q9Z1P8, ECO:0000269|PubMed:14583458, ECO:0000269|PubMed:17068295, ECO:0000269|PubMed:19270337, ECO:0000269|PubMed:21398697, ECO:0000269|PubMed:27929370, ECO:0000269|PubMed:29899144, ECO:0000305|PubMed:29899519}.; FUNCTION: [ANGPTL4 N-terminal chain]: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism (PubMed:19270337, PubMed:21398697, PubMed:27929370, PubMed:29899144). Has higher activity in LPL inactivation than the uncleaved protein (PubMed:19270337, PubMed:21398697). {ECO:0000269|PubMed:19270337, ECO:0000269|PubMed:21398697, ECO:0000269|PubMed:27929370, ECO:0000269|PubMed:29899144}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+12138_4653871.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+12038_4653867.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+12138_4653871.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+12038_4653867.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+12138_4653870.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+12138_4553871.0RegionG1 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+12038_4553867.0RegionG1 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+12138_4553871.0RegionG1 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+12038_4553867.0RegionG1 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+12138_4553870.0RegionG1 motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121747_86653871.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120747_86653867.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121747_86653871.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120747_86653867.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121747_86653870.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+12128_29453871.0DomainDynamin-type G
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121519_62553871.0DomainPH
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121653_74453871.0DomainGED
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+12028_29453867.0DomainDynamin-type G
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120519_62553867.0DomainPH
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120653_74453867.0DomainGED
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+12128_29453871.0DomainDynamin-type G
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121519_62553871.0DomainPH
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121653_74453871.0DomainGED
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+12028_29453867.0DomainDynamin-type G
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120519_62553867.0DomainPH
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120653_74453867.0DomainGED
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+12128_29453870.0DomainDynamin-type G
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121519_62553870.0DomainPH
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121653_74453870.0DomainGED
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121205_21153871.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121236_23953871.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120205_21153867.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120236_23953867.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121205_21153871.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121236_23953871.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120205_21153867.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120236_23953867.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121205_21153870.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121236_23953870.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121136_13953871.0RegionG3 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121205_20853871.0RegionG4 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121235_23853871.0RegionG5 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+12164_6653871.0RegionG2 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120136_13953867.0RegionG3 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120205_20853867.0RegionG4 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120235_23853867.0RegionG5 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+12064_6653867.0RegionG2 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121136_13953871.0RegionG3 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121205_20853871.0RegionG4 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121235_23853871.0RegionG5 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+12164_6653871.0RegionG2 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120136_13953867.0RegionG3 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120205_20853867.0RegionG4 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120235_23853867.0RegionG5 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+12064_6653867.0RegionG2 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121136_13953870.0RegionG3 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121205_20853870.0RegionG4 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121235_23853870.0RegionG5 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+12164_6653870.0RegionG2 motif
TgeneANGPTL4chr19:10829079chr19:8438589ENST0000030145557100_143346407.0Coiled coilOntology_term=ECO:0000255
TgeneANGPTL4chr19:10829079chr19:8438589ENST0000039396246100_143308369.0Coiled coilOntology_term=ECO:0000255
TgeneANGPTL4chr19:10829079chr19:8438589ENST0000030145557179_401346407.0DomainFibrinogen C-terminal
TgeneANGPTL4chr19:10829079chr19:8438589ENST0000039396246179_401308369.0DomainFibrinogen C-terminal


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Fusion Gene Sequence for DNM2-ANGPTL4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>23631_23631_1_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000314646_ANGPTL4_chr19_8438589_ENST00000301455_length(transcript)=994nt_BP=325nt
GAGAACCGGATGAGGCGGCGACCGTGAGGCCGAGCCGGGAGCGGGCGTCTTGCCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACG
CCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGA
TGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTG
TAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCACCTGCAGCCATTCCAAC
CTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTGGCGGGGCCGCTACTAC
CCGCTGCAGGCCACCACCATGTTGATCCAGCCCATGGCAGCAGAGGCAGCCTCCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCCCACGAA
AGACGGTGACTCTTGGCTCTGCCCGAGGATGTGGCCGTTCCCTGCCTGGGCAGGGGCTCCAAGGAGGGGCCATCTGGAAACTTGTGGACA
GAGAAGAAGACCACGACTGGAGAAGCCCCCTTTCTGAGTGCAGGGGGGCTGCATGCGTTGCCTCCTGAGATCGAGGCTGCAGGATATGCT
CAGACTCTAGAGGCGTGGACCAAGGGGCATGGAGCTTCACTCCTTGCTGGCCAGGGAGTTGGGGACTCAGAGGGACCACTTGGGGCCAGC
CAGACTGGCCTCAATGGCGGACTCAGTCACATTGACTGACGGGGACCAGGGCTTGTGTGGGTCGAGAGCGCCCTCATGGTGCTGGTGCTG
TTGTGTGTAGGTCCCCTGGGGACACAAGCAGGCGCCAATGGTATCTGGGCGGAGCTCACAGAGTTCTTGGAATAAAAGCAACCTCAGAAC

>23631_23631_1_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000314646_ANGPTL4_chr19_8438589_ENST00000301455_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------
>23631_23631_2_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000314646_ANGPTL4_chr19_8438589_ENST00000393962_length(transcript)=952nt_BP=325nt
GAGAACCGGATGAGGCGGCGACCGTGAGGCCGAGCCGGGAGCGGGCGTCTTGCCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACG
CCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGA
TGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTG
TAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCACCTGCAGCCATTCCAAC
CTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTGGCGGGGCCGCTACTAC
CCGCTGCAGGCCACCACCATGTTGATCCAGCCCATGGCAGCAGAGGCAGCCTCCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCCCACGAA
AGACGGTGACTCTTGGCTCTGCCCGAGGATGTGGCCGTTCCCTGCCTGGGCAGGGGCTCCAAGGAGGGGCCATCTGGAAACTTGTGGACA
GAGAAGAAGACCACGACTGGAGAAGCCCCCTTTCTGAGTGCAGGGGGGCTGCATGCGTTGCCTCCTGAGATCGAGGCTGCAGGATATGCT
CAGACTCTAGAGGCGTGGACCAAGGGGCATGGAGCTTCACTCCTTGCTGGCCAGGGAGTTGGGGACTCAGAGGGACCACTTGGGGCCAGC
CAGACTGGCCTCAATGGCGGACTCAGTCACATTGACTGACGGGGACCAGGGCTTGTGTGGGTCGAGAGCGCCCTCATGGTGCTGGTGCTG

>23631_23631_2_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000314646_ANGPTL4_chr19_8438589_ENST00000393962_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------
>23631_23631_3_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000355667_ANGPTL4_chr19_8438589_ENST00000301455_length(transcript)=910nt_BP=241nt
CAGACGCCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACC
GCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGA
TCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCACCTGCAGCCAT
TCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTGGCGGGGCCGC
TACTACCCGCTGCAGGCCACCACCATGTTGATCCAGCCCATGGCAGCAGAGGCAGCCTCCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCC
CACGAAAGACGGTGACTCTTGGCTCTGCCCGAGGATGTGGCCGTTCCCTGCCTGGGCAGGGGCTCCAAGGAGGGGCCATCTGGAAACTTG
TGGACAGAGAAGAAGACCACGACTGGAGAAGCCCCCTTTCTGAGTGCAGGGGGGCTGCATGCGTTGCCTCCTGAGATCGAGGCTGCAGGA
TATGCTCAGACTCTAGAGGCGTGGACCAAGGGGCATGGAGCTTCACTCCTTGCTGGCCAGGGAGTTGGGGACTCAGAGGGACCACTTGGG
GCCAGCCAGACTGGCCTCAATGGCGGACTCAGTCACATTGACTGACGGGGACCAGGGCTTGTGTGGGTCGAGAGCGCCCTCATGGTGCTG
GTGCTGTTGTGTGTAGGTCCCCTGGGGACACAAGCAGGCGCCAATGGTATCTGGGCGGAGCTCACAGAGTTCTTGGAATAAAAGCAACCT

>23631_23631_3_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000355667_ANGPTL4_chr19_8438589_ENST00000301455_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------
>23631_23631_4_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000355667_ANGPTL4_chr19_8438589_ENST00000393962_length(transcript)=868nt_BP=241nt
CAGACGCCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACC
GCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGA
TCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCACCTGCAGCCAT
TCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTGGCGGGGCCGC
TACTACCCGCTGCAGGCCACCACCATGTTGATCCAGCCCATGGCAGCAGAGGCAGCCTCCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCC
CACGAAAGACGGTGACTCTTGGCTCTGCCCGAGGATGTGGCCGTTCCCTGCCTGGGCAGGGGCTCCAAGGAGGGGCCATCTGGAAACTTG
TGGACAGAGAAGAAGACCACGACTGGAGAAGCCCCCTTTCTGAGTGCAGGGGGGCTGCATGCGTTGCCTCCTGAGATCGAGGCTGCAGGA
TATGCTCAGACTCTAGAGGCGTGGACCAAGGGGCATGGAGCTTCACTCCTTGCTGGCCAGGGAGTTGGGGACTCAGAGGGACCACTTGGG
GCCAGCCAGACTGGCCTCAATGGCGGACTCAGTCACATTGACTGACGGGGACCAGGGCTTGTGTGGGTCGAGAGCGCCCTCATGGTGCTG

>23631_23631_4_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000355667_ANGPTL4_chr19_8438589_ENST00000393962_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------
>23631_23631_5_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000359692_ANGPTL4_chr19_8438589_ENST00000301455_length(transcript)=980nt_BP=311nt
GCGGCGACCGTGAGGCCGAGCCGGGAGCGGGCGTCTTGCCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACGCCGCGGGGCCAGGT
CGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGATGGAAGAGCTGATC
CCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTGTAGTGGGCGGCCAG
AGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCACCTGCAGCCATTCCAACCTCAACGGCCAGTA
CTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTGGCGGGGCCGCTACTACCCGCTGCAGGCCAC
CACCATGTTGATCCAGCCCATGGCAGCAGAGGCAGCCTCCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCCCACGAAAGACGGTGACTCTT
GGCTCTGCCCGAGGATGTGGCCGTTCCCTGCCTGGGCAGGGGCTCCAAGGAGGGGCCATCTGGAAACTTGTGGACAGAGAAGAAGACCAC
GACTGGAGAAGCCCCCTTTCTGAGTGCAGGGGGGCTGCATGCGTTGCCTCCTGAGATCGAGGCTGCAGGATATGCTCAGACTCTAGAGGC
GTGGACCAAGGGGCATGGAGCTTCACTCCTTGCTGGCCAGGGAGTTGGGGACTCAGAGGGACCACTTGGGGCCAGCCAGACTGGCCTCAA
TGGCGGACTCAGTCACATTGACTGACGGGGACCAGGGCTTGTGTGGGTCGAGAGCGCCCTCATGGTGCTGGTGCTGTTGTGTGTAGGTCC

>23631_23631_5_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000359692_ANGPTL4_chr19_8438589_ENST00000301455_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------
>23631_23631_6_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000359692_ANGPTL4_chr19_8438589_ENST00000393962_length(transcript)=938nt_BP=311nt
GCGGCGACCGTGAGGCCGAGCCGGGAGCGGGCGTCTTGCCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACGCCGCGGGGCCAGGT
CGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGATGGAAGAGCTGATC
CCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTGTAGTGGGCGGCCAG
AGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCACCTGCAGCCATTCCAACCTCAACGGCCAGTA
CTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTGGCGGGGCCGCTACTACCCGCTGCAGGCCAC
CACCATGTTGATCCAGCCCATGGCAGCAGAGGCAGCCTCCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCCCACGAAAGACGGTGACTCTT
GGCTCTGCCCGAGGATGTGGCCGTTCCCTGCCTGGGCAGGGGCTCCAAGGAGGGGCCATCTGGAAACTTGTGGACAGAGAAGAAGACCAC
GACTGGAGAAGCCCCCTTTCTGAGTGCAGGGGGGCTGCATGCGTTGCCTCCTGAGATCGAGGCTGCAGGATATGCTCAGACTCTAGAGGC
GTGGACCAAGGGGCATGGAGCTTCACTCCTTGCTGGCCAGGGAGTTGGGGACTCAGAGGGACCACTTGGGGCCAGCCAGACTGGCCTCAA
TGGCGGACTCAGTCACATTGACTGACGGGGACCAGGGCTTGTGTGGGTCGAGAGCGCCCTCATGGTGCTGGTGCTGTTGTGTGTAGGTCC

>23631_23631_6_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000359692_ANGPTL4_chr19_8438589_ENST00000393962_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------
>23631_23631_7_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000389253_ANGPTL4_chr19_8438589_ENST00000301455_length(transcript)=942nt_BP=273nt
CCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACGCCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCT
CGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCAT
CGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGG
CCGGAGGCTGGTGGTTTGGCACCTGCAGCCATTCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGA
AGGGAATCTTCTGGAAGACCTGGCGGGGCCGCTACTACCCGCTGCAGGCCACCACCATGTTGATCCAGCCCATGGCAGCAGAGGCAGCCT
CCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCCCACGAAAGACGGTGACTCTTGGCTCTGCCCGAGGATGTGGCCGTTCCCTGCCTGGGCA
GGGGCTCCAAGGAGGGGCCATCTGGAAACTTGTGGACAGAGAAGAAGACCACGACTGGAGAAGCCCCCTTTCTGAGTGCAGGGGGGCTGC
ATGCGTTGCCTCCTGAGATCGAGGCTGCAGGATATGCTCAGACTCTAGAGGCGTGGACCAAGGGGCATGGAGCTTCACTCCTTGCTGGCC
AGGGAGTTGGGGACTCAGAGGGACCACTTGGGGCCAGCCAGACTGGCCTCAATGGCGGACTCAGTCACATTGACTGACGGGGACCAGGGC
TTGTGTGGGTCGAGAGCGCCCTCATGGTGCTGGTGCTGTTGTGTGTAGGTCCCCTGGGGACACAAGCAGGCGCCAATGGTATCTGGGCGG

>23631_23631_7_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000389253_ANGPTL4_chr19_8438589_ENST00000301455_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------
>23631_23631_8_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000389253_ANGPTL4_chr19_8438589_ENST00000393962_length(transcript)=900nt_BP=273nt
CCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACGCCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCT
CGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCAT
CGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGG
CCGGAGGCTGGTGGTTTGGCACCTGCAGCCATTCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGA
AGGGAATCTTCTGGAAGACCTGGCGGGGCCGCTACTACCCGCTGCAGGCCACCACCATGTTGATCCAGCCCATGGCAGCAGAGGCAGCCT
CCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCCCACGAAAGACGGTGACTCTTGGCTCTGCCCGAGGATGTGGCCGTTCCCTGCCTGGGCA
GGGGCTCCAAGGAGGGGCCATCTGGAAACTTGTGGACAGAGAAGAAGACCACGACTGGAGAAGCCCCCTTTCTGAGTGCAGGGGGGCTGC
ATGCGTTGCCTCCTGAGATCGAGGCTGCAGGATATGCTCAGACTCTAGAGGCGTGGACCAAGGGGCATGGAGCTTCACTCCTTGCTGGCC
AGGGAGTTGGGGACTCAGAGGGACCACTTGGGGCCAGCCAGACTGGCCTCAATGGCGGACTCAGTCACATTGACTGACGGGGACCAGGGC
TTGTGTGGGTCGAGAGCGCCCTCATGGTGCTGGTGCTGTTGTGTGTAGGTCCCCTGGGGACACAAGCAGGCGCCAATGGTATCTGGGCGG

>23631_23631_8_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000389253_ANGPTL4_chr19_8438589_ENST00000393962_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------
>23631_23631_9_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000408974_ANGPTL4_chr19_8438589_ENST00000301455_length(transcript)=865nt_BP=196nt
AGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACG
CCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGG
AGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCACCTGCAGCCATTCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGG
CAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTGGCGGGGCCGCTACTACCCGCTGCAGGCCACCACCATGTTGATCCAGCCCATGGCA
GCAGAGGCAGCCTCCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCCCACGAAAGACGGTGACTCTTGGCTCTGCCCGAGGATGTGGCCGTT
CCCTGCCTGGGCAGGGGCTCCAAGGAGGGGCCATCTGGAAACTTGTGGACAGAGAAGAAGACCACGACTGGAGAAGCCCCCTTTCTGAGT
GCAGGGGGGCTGCATGCGTTGCCTCCTGAGATCGAGGCTGCAGGATATGCTCAGACTCTAGAGGCGTGGACCAAGGGGCATGGAGCTTCA
CTCCTTGCTGGCCAGGGAGTTGGGGACTCAGAGGGACCACTTGGGGCCAGCCAGACTGGCCTCAATGGCGGACTCAGTCACATTGACTGA
CGGGGACCAGGGCTTGTGTGGGTCGAGAGCGCCCTCATGGTGCTGGTGCTGTTGTGTGTAGGTCCCCTGGGGACACAAGCAGGCGCCAAT

>23631_23631_9_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000408974_ANGPTL4_chr19_8438589_ENST00000301455_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------
>23631_23631_10_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000408974_ANGPTL4_chr19_8438589_ENST00000393962_length(transcript)=823nt_BP=196nt
AGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACG
CCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGG
AGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCACCTGCAGCCATTCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGG
CAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTGGCGGGGCCGCTACTACCCGCTGCAGGCCACCACCATGTTGATCCAGCCCATGGCA
GCAGAGGCAGCCTCCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCCCACGAAAGACGGTGACTCTTGGCTCTGCCCGAGGATGTGGCCGTT
CCCTGCCTGGGCAGGGGCTCCAAGGAGGGGCCATCTGGAAACTTGTGGACAGAGAAGAAGACCACGACTGGAGAAGCCCCCTTTCTGAGT
GCAGGGGGGCTGCATGCGTTGCCTCCTGAGATCGAGGCTGCAGGATATGCTCAGACTCTAGAGGCGTGGACCAAGGGGCATGGAGCTTCA
CTCCTTGCTGGCCAGGGAGTTGGGGACTCAGAGGGACCACTTGGGGCCAGCCAGACTGGCCTCAATGGCGGACTCAGTCACATTGACTGA
CGGGGACCAGGGCTTGTGTGGGTCGAGAGCGCCCTCATGGTGCTGGTGCTGTTGTGTGTAGGTCCCCTGGGGACACAAGCAGGCGCCAAT

>23631_23631_10_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000408974_ANGPTL4_chr19_8438589_ENST00000393962_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------
>23631_23631_11_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000585892_ANGPTL4_chr19_8438589_ENST00000301455_length(transcript)=994nt_BP=325nt
GAGAACCGGATGAGGCGGCGACCGTGAGGCCGAGCCGGGAGCGGGCGTCTTGCCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACG
CCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGA
TGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTG
TAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCACCTGCAGCCATTCCAAC
CTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTGGCGGGGCCGCTACTAC
CCGCTGCAGGCCACCACCATGTTGATCCAGCCCATGGCAGCAGAGGCAGCCTCCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCCCACGAA
AGACGGTGACTCTTGGCTCTGCCCGAGGATGTGGCCGTTCCCTGCCTGGGCAGGGGCTCCAAGGAGGGGCCATCTGGAAACTTGTGGACA
GAGAAGAAGACCACGACTGGAGAAGCCCCCTTTCTGAGTGCAGGGGGGCTGCATGCGTTGCCTCCTGAGATCGAGGCTGCAGGATATGCT
CAGACTCTAGAGGCGTGGACCAAGGGGCATGGAGCTTCACTCCTTGCTGGCCAGGGAGTTGGGGACTCAGAGGGACCACTTGGGGCCAGC
CAGACTGGCCTCAATGGCGGACTCAGTCACATTGACTGACGGGGACCAGGGCTTGTGTGGGTCGAGAGCGCCCTCATGGTGCTGGTGCTG
TTGTGTGTAGGTCCCCTGGGGACACAAGCAGGCGCCAATGGTATCTGGGCGGAGCTCACAGAGTTCTTGGAATAAAAGCAACCTCAGAAC

>23631_23631_11_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000585892_ANGPTL4_chr19_8438589_ENST00000301455_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------
>23631_23631_12_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000585892_ANGPTL4_chr19_8438589_ENST00000393962_length(transcript)=952nt_BP=325nt
GAGAACCGGATGAGGCGGCGACCGTGAGGCCGAGCCGGGAGCGGGCGTCTTGCCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACG
CCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGA
TGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTG
TAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGAGGCTGGTGGTTTGGCACCTGCAGCCATTCCAAC
CTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTGGCGGGGCCGCTACTAC
CCGCTGCAGGCCACCACCATGTTGATCCAGCCCATGGCAGCAGAGGCAGCCTCCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCCCACGAA
AGACGGTGACTCTTGGCTCTGCCCGAGGATGTGGCCGTTCCCTGCCTGGGCAGGGGCTCCAAGGAGGGGCCATCTGGAAACTTGTGGACA
GAGAAGAAGACCACGACTGGAGAAGCCCCCTTTCTGAGTGCAGGGGGGCTGCATGCGTTGCCTCCTGAGATCGAGGCTGCAGGATATGCT
CAGACTCTAGAGGCGTGGACCAAGGGGCATGGAGCTTCACTCCTTGCTGGCCAGGGAGTTGGGGACTCAGAGGGACCACTTGGGGCCAGC
CAGACTGGCCTCAATGGCGGACTCAGTCACATTGACTGACGGGGACCAGGGCTTGTGTGGGTCGAGAGCGCCCTCATGGTGCTGGTGCTG

>23631_23631_12_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000585892_ANGPTL4_chr19_8438589_ENST00000393962_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DNM2-ANGPTL4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DNM2-ANGPTL4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DNM2-ANGPTL4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource