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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DNMT1-FDX1L (FusionGDB2 ID:23695)

Fusion Gene Summary for DNMT1-FDX1L

check button Fusion gene summary
Fusion gene informationFusion gene name: DNMT1-FDX1L
Fusion gene ID: 23695
HgeneTgene
Gene symbol

DNMT1

FDX1L

Gene ID

1786

112812

Gene nameDNA methyltransferase 1ferredoxin 2
SynonymsADCADN|AIM|CXXC9|DNMT|HSN1E|MCMT|m.HsaIFDX1L|MEOAL
Cytomap

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
DescriptionDNA (cytosine-5)-methyltransferase 1CXXC-type zinc finger protein 9DNA (cytosine-5-)-methyltransferase 1DNA MTase HsaIDNA methyltransferase HsaIferredoxin-2, mitochondrialadrenodoxin-like protein, mitochondrialferredoxin 1 like
Modification date2020031320200313
UniProtAcc

P26358

.
Ensembl transtripts involved in fusion geneENST00000340748, ENST00000359526, 
ENST00000540357, ENST00000589538, 
ENST00000492239, ENST00000494368, 
ENST00000393708, ENST00000541276, 
Fusion gene scores* DoF score14 X 12 X 11=18486 X 3 X 5=90
# samples 177
** MAII scorelog2(17/1848*10)=-3.44235810527836
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/90*10)=-0.362570079384708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNMT1 [Title/Abstract] AND FDX1L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNMT1(10283766)-FDX1L(10421616), # samples:1
DNMT1(10283766)-FDX1L(10426435), # samples:1
Anticipated loss of major functional domain due to fusion event.DNMT1-FDX1L seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
DNMT1-FDX1L seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
DNMT1-FDX1L seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
DNMT1-FDX1L seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
DNMT1-FDX1L seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
DNMT1-FDX1L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNMT1

GO:0010216

maintenance of DNA methylation

18754681|21745816


check buttonFusion gene breakpoints across DNMT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FDX1L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-DD-A3A5-01ADNMT1chr19

10283766

-FDX1Lchr19

10421616

-
ChimerDB4UVMTCGA-V4-A9EX-01ADNMT1chr19

10283766

-FDX1Lchr19

10426435

-


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Fusion Gene ORF analysis for DNMT1-FDX1L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000340748ENST00000492239DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
5CDS-5UTRENST00000340748ENST00000492239DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
5CDS-5UTRENST00000340748ENST00000494368DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
5CDS-5UTRENST00000340748ENST00000494368DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
5CDS-5UTRENST00000359526ENST00000492239DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
5CDS-5UTRENST00000359526ENST00000492239DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
5CDS-5UTRENST00000359526ENST00000494368DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
5CDS-5UTRENST00000359526ENST00000494368DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
5CDS-5UTRENST00000540357ENST00000492239DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
5CDS-5UTRENST00000540357ENST00000492239DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
5CDS-5UTRENST00000540357ENST00000494368DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
5CDS-5UTRENST00000540357ENST00000494368DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
Frame-shiftENST00000340748ENST00000393708DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
Frame-shiftENST00000340748ENST00000393708DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
Frame-shiftENST00000359526ENST00000393708DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
Frame-shiftENST00000359526ENST00000393708DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
Frame-shiftENST00000540357ENST00000393708DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
Frame-shiftENST00000540357ENST00000393708DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
In-frameENST00000340748ENST00000541276DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
In-frameENST00000340748ENST00000541276DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
In-frameENST00000359526ENST00000541276DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
In-frameENST00000359526ENST00000541276DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
In-frameENST00000540357ENST00000541276DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
In-frameENST00000540357ENST00000541276DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
intron-3CDSENST00000589538ENST00000393708DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
intron-3CDSENST00000589538ENST00000393708DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
intron-3CDSENST00000589538ENST00000541276DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
intron-3CDSENST00000589538ENST00000541276DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
intron-5UTRENST00000589538ENST00000492239DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
intron-5UTRENST00000589538ENST00000492239DNMT1chr19

10283766

-FDX1Lchr19

10426435

-
intron-5UTRENST00000589538ENST00000494368DNMT1chr19

10283766

-FDX1Lchr19

10421616

-
intron-5UTRENST00000589538ENST00000494368DNMT1chr19

10283766

-FDX1Lchr19

10426435

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000340748DNMT1chr1910283766-ENST00000541276FDX1Lchr1910421616-2592956441003319
ENST00000540357DNMT1chr1910283766-ENST00000541276FDX1Lchr1910421616-2536900180947255
ENST00000359526DNMT1chr1910283766-ENST00000541276FDX1Lchr1910421616-2584948180995271
ENST00000340748DNMT1chr1910283766-ENST00000541276FDX1Lchr1910426435-2754956441015323
ENST00000540357DNMT1chr1910283766-ENST00000541276FDX1Lchr1910426435-2698900180959259
ENST00000359526DNMT1chr1910283766-ENST00000541276FDX1Lchr1910426435-27469481801007275

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000340748ENST00000541276DNMT1chr1910283766-FDX1Lchr1910421616-0.0285038520.97149616
ENST00000540357ENST00000541276DNMT1chr1910283766-FDX1Lchr1910421616-0.012095410.9879046
ENST00000359526ENST00000541276DNMT1chr1910283766-FDX1Lchr1910421616-0.0115858660.98841405
ENST00000340748ENST00000541276DNMT1chr1910283766-FDX1Lchr1910426435-0.0341340820.9658659
ENST00000540357ENST00000541276DNMT1chr1910283766-FDX1Lchr1910426435-0.0129326240.9870674
ENST00000359526ENST00000541276DNMT1chr1910283766-FDX1Lchr1910426435-0.0098579470.99014205

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Fusion Genomic Features for DNMT1-FDX1L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DNMT1-FDX1L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:10283766/chr19:10421616)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNMT1

P26358

.
FUNCTION: Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-84016_1092401617.0DomainDMAP1-binding
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-94116_1092561633.0DomainDMAP1-binding
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-84016_1092401617.0DomainDMAP1-binding
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-94116_1092561633.0DomainDMAP1-binding
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-840177_2052401617.0MotifNuclear localization signal
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-941177_2052561633.0MotifNuclear localization signal
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-840177_2052401617.0MotifNuclear localization signal
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-941177_2052561633.0MotifNuclear localization signal
TgeneFDX1Lchr19:10283766chr19:10426435ENST000003937080571_17348184.0Domain2Fe-2S ferredoxin-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401139_15992401617.0DomainSAM-dependent MTase C5-type
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-840755_8802401617.0DomainBAH 1
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-840972_11002401617.0DomainBAH 2
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411139_15992561633.0DomainSAM-dependent MTase C5-type
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-941755_8802561633.0DomainBAH 1
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-941972_11002561633.0DomainBAH 2
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401139_15992401617.0DomainSAM-dependent MTase C5-type
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-840755_8802401617.0DomainBAH 1
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-840972_11002401617.0DomainBAH 2
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411139_15992561633.0DomainSAM-dependent MTase C5-type
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-941755_8802561633.0DomainBAH 1
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-941972_11002561633.0DomainBAH 2
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401109_11202401617.0RegionNote=6 X 2 AA tandem repeats of K-G
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401139_16162401617.0RegionNote=Catalytic
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401150_11512401617.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401168_11692401617.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401190_11912401617.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-840310_5022401617.0RegionNote=Homodimerization
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-840331_5502401617.0RegionDNA replication foci-targeting sequence
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-840651_6972401617.0RegionNote=Required for activity
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-840693_7542401617.0RegionNote=Autoinhibitory linker
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411109_11202561633.0RegionNote=6 X 2 AA tandem repeats of K-G
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411139_16162561633.0RegionNote=Catalytic
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411150_11512561633.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411168_11692561633.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411190_11912561633.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-941310_5022561633.0RegionNote=Homodimerization
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-941331_5502561633.0RegionDNA replication foci-targeting sequence
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-941651_6972561633.0RegionNote=Required for activity
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-941693_7542561633.0RegionNote=Autoinhibitory linker
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401109_11202401617.0RegionNote=6 X 2 AA tandem repeats of K-G
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401139_16162401617.0RegionNote=Catalytic
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401150_11512401617.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401168_11692401617.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401190_11912401617.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-840310_5022401617.0RegionNote=Homodimerization
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-840331_5502401617.0RegionDNA replication foci-targeting sequence
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-840651_6972401617.0RegionNote=Required for activity
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-840693_7542401617.0RegionNote=Autoinhibitory linker
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411109_11202561633.0RegionNote=6 X 2 AA tandem repeats of K-G
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411139_16162561633.0RegionNote=Catalytic
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411150_11512561633.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411168_11692561633.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411190_11912561633.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-941310_5022561633.0RegionNote=Homodimerization
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-941331_5502561633.0RegionDNA replication foci-targeting sequence
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-941651_6972561633.0RegionNote=Required for activity
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-941693_7542561633.0RegionNote=Autoinhibitory linker
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401109_11102401617.0RepeatNote=1
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401111_11122401617.0RepeatNote=2
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401113_11142401617.0RepeatNote=3
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401115_11162401617.0RepeatNote=4
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401117_11182401617.0RepeatNote=5
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401119_11202401617.0RepeatNote=6%3B approximate
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411109_11102561633.0RepeatNote=1
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411111_11122561633.0RepeatNote=2
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411113_11142561633.0RepeatNote=3
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411115_11162561633.0RepeatNote=4
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411117_11182561633.0RepeatNote=5
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411119_11202561633.0RepeatNote=6%3B approximate
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401109_11102401617.0RepeatNote=1
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401111_11122401617.0RepeatNote=2
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401113_11142401617.0RepeatNote=3
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401115_11162401617.0RepeatNote=4
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401117_11182401617.0RepeatNote=5
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401119_11202401617.0RepeatNote=6%3B approximate
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411109_11102561633.0RepeatNote=1
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411111_11122561633.0RepeatNote=2
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411113_11142561633.0RepeatNote=3
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411115_11162561633.0RepeatNote=4
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411117_11182561633.0RepeatNote=5
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411119_11202561633.0RepeatNote=6%3B approximate
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-840646_6922401617.0Zinc fingerCXXC-type
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-941646_6922561633.0Zinc fingerCXXC-type
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-840646_6922401617.0Zinc fingerCXXC-type
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-941646_6922561633.0Zinc fingerCXXC-type
TgeneFDX1Lchr19:10283766chr19:10421616ENST000003937082571_173102184.0Domain2Fe-2S ferredoxin-type


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Fusion Gene Sequence for DNMT1-FDX1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>23695_23695_1_DNMT1-FDX1L_DNMT1_chr19_10283766_ENST00000340748_FDX1L_chr19_10421616_ENST00000541276_length(transcript)=2592nt_BP=956nt
TCCGCGTGGGGGGGGTGTGTGCCCGCCTTGCGCATGCGTGTTCCCTGGGCATGGCCGGCTCCGTTCCATCCTTCTGCACAGGGTATCGCC
TCTCTCCGTTTGGTACATCCCCTCCTCCCCCACGCCCGGACTGGGGTGGTAGACGCCGCCTCCGCTCATCGCCCCTCCCCATCGGTTTCC
GCGCGAAAAGCCGGGGCGCCTGCGCTGCCGCCGCCGCGTCTGCTGAAGCCTCCGAGATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCA
CACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGATTTGGAAAGAGACAGCTTAACAGAAAAGGAATGTG
TGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAGTTATGTGACTTGGAAACCAAATTACGTAAAGAAG
AATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTGTCCTTGGAGAACGGTGCTCATGCTTACAACCGGG
AAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTGGGAATGGCAGATGCCAACAGCCCCCCCAAACCCC
TTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCCTGAACCTTCACCTAGCCCCAGGATTACAAGGAAAAGCA
CCAGGCAAACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCTCAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGT
CCATCAAGGAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGAGAACGAGTTGCTAGACCGCTTCCTGCAGAAGAAC
CTGAAAGAGCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAAGGGCCTGTGAAGCCTCCCTGGCCTGCTCCACCTG
CCATGTGTATGTGAGTGAAGACCACCTGGATCTCCTGCCTCCTCCCGAGGAGAGGAGAACTCGCGGCTGGGCTGCCAGATTGTGCTGACA
CCGGAGCTGGAAGGAGCGGAATTCACCCTGCCCAAGATCACCAGGAACTTCTACGTGGATGGCCATGTCCCCAAGCCCCACTGACATGAA
CACCTGGACCATTCCACATTGCCATGGCCCCAGGGCCCAGATTGAGGGAATAGCCAGGTGCCAGCCCTGCCCAGAGTGCGGACAGGCCCG
GGAGAGACGTGGAAGCCCCTGTGAAGGACAACACCCCTGCTTGGGAGAGAGTCCCATGTCCAGGCCCCTGAGAATCAGGGTTTGAGTAGG
AGTGGACTCATATTGGAGCTGCAATAAATCGATAACACAGGCCCCAGCATGTTGAGTGTCCTTGGGGGACAGATCTGGGGTCTACAGGTG
GCTCACACCTGTAATCCTAGCACTTTGGGAAGCCAAGATGGGAGGATCACTTGAGGCCAGGAGCTTAAGACCATCCTGGGCAACATGGCG
AGACCTCGTCTCTATAAAAACAGTAAAAATTAGCGTGGAGTGGTGGTAAGTGCCTGTAGTCCCAGCTACTCGGGAGACTGAGGTGGGAGG
ATCACTTGAGCCCAGGGGATTTAGGCTGCAGTGGAGCGGTGATCAGGCCATTCCACTCCAGCCTGGGTGACAGAGTGAGGCCCTGTCTCA
AAAAAAAAAAAAACAAAAACAAAAACAAACCACACCTGCATCTGCTGTGCTGGGCCCCCGGTTCTCTTTTCCCTCTGGGATCTAAGATGC
CGCTGGGGATCCAAGGCAGAGGCCTGGGAGCCCCCATTTCCGAGGGGGAGGGCTAGCGTGGAAGGCCCCGCCCCGGCAGCTGCGGAGGGA
TTTGGTGGGGTCCAGGCCGCCCTTGCCACGCAGGGGTGCGCGGATGACCTGAAAAAAGCCAGAAAGAGGAAAGGTGCCGCCGAGGCTGGT
CGCTCTCAGCTGGGGCTCATCGCATCCTCTACCAAGAGCGCTCCCACCACACAGGTCCCGCCCCTCCCAGCAAAGCTTCTGGCGCCGCCC
TGTCTGAACCTGGAGCGGCTGGGAGGATCCCCCTCCCAGGAGAAGCCGAGGACCCCAGGATGCTGCAGAATCAGTGAGAGGTCCCTCTGG
CCTGCATGCCAGGAGTCGGTCACCGCCCTGTGCTTCCTCCAAGAGACAGTGGAGAGGCTGGGGATTCCAAGGACACACAGACCAGGATCA
GCCAAAAGGGCCGCCGTCTGCAGCCCCCGGGGACTCCCTCGGCCCCACCCCAGAGAAGGCCCCGGAAACAGCTGAACCCCTGCCGGGGCA
CCGAGAGAGTGGACCCTGGGTTCGAGGGGGTGACTCTGAAGTTTCAGATAAAGCCGGACTCCAGCCTGCAGATCATCCCCACGTACAGCC
TGCCCTGCAGTAGCCGTTCTCAGGAATCCCCTGCAGATGCTGTTGGGGGCCCTGCAGCCCACCCAGGAGGCACCGAGGCCCACTCAGCAG

>23695_23695_1_DNMT1-FDX1L_DNMT1_chr19_10283766_ENST00000340748_FDX1L_chr19_10421616_ENST00000541276_length(amino acids)=319AA_BP=304
MGMAGSVPSFCTGYRLSPFGTSPPPPRPDWGGRRRLRSSPLPIGFRAKSRGACAAAAASAEASEMPARTAPARVPTLAVPAISLPDDVRR
RLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNREVNGRLENGNQARSE
ARRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDEKRRR

--------------------------------------------------------------
>23695_23695_2_DNMT1-FDX1L_DNMT1_chr19_10283766_ENST00000340748_FDX1L_chr19_10426435_ENST00000541276_length(transcript)=2754nt_BP=956nt
TCCGCGTGGGGGGGGTGTGTGCCCGCCTTGCGCATGCGTGTTCCCTGGGCATGGCCGGCTCCGTTCCATCCTTCTGCACAGGGTATCGCC
TCTCTCCGTTTGGTACATCCCCTCCTCCCCCACGCCCGGACTGGGGTGGTAGACGCCGCCTCCGCTCATCGCCCCTCCCCATCGGTTTCC
GCGCGAAAAGCCGGGGCGCCTGCGCTGCCGCCGCCGCGTCTGCTGAAGCCTCCGAGATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCA
CACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGATTTGGAAAGAGACAGCTTAACAGAAAAGGAATGTG
TGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAGTTATGTGACTTGGAAACCAAATTACGTAAAGAAG
AATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTGTCCTTGGAGAACGGTGCTCATGCTTACAACCGGG
AAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTGGGAATGGCAGATGCCAACAGCCCCCCCAAACCCC
TTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCCTGAACCTTCACCTAGCCCCAGGATTACAAGGAAAAGCA
CCAGGCAAACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCTCAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGT
CCATCAAGGAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGAGAACGAGTTGCTAGACCGCTTCCTGCAGAAGAAC
CTGAAAGAGCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAAGCTCGCGCCCGGCTGGAGAGGAGGACGCGGGCGG
CCCGGAGCGGCCCGGGGACGTGGTGAACGTGGTGTTCGTAGACCGCTCAGGCCAGCGGATCCCAGTGAGTGGCAGAGTCGGGGACAATGT
TCTTCACCTGGCCCAGCGCCACGGGGTGGACCTGGAAGGGGCCTGTGAAGCCTCCCTGGCCTGCTCCACCTGCCATGTGTATGTGAGTGA
AGACCACCTGGATCTCCTGCCTCCTCCCGAGGAGAGGAGAACTCGCGGCTGGGCTGCCAGATTGTGCTGACACCGGAGCTGGAAGGAGCG
GAATTCACCCTGCCCAAGATCACCAGGAACTTCTACGTGGATGGCCATGTCCCCAAGCCCCACTGACATGAACACCTGGACCATTCCACA
TTGCCATGGCCCCAGGGCCCAGATTGAGGGAATAGCCAGGTGCCAGCCCTGCCCAGAGTGCGGACAGGCCCGGGAGAGACGTGGAAGCCC
CTGTGAAGGACAACACCCCTGCTTGGGAGAGAGTCCCATGTCCAGGCCCCTGAGAATCAGGGTTTGAGTAGGAGTGGACTCATATTGGAG
CTGCAATAAATCGATAACACAGGCCCCAGCATGTTGAGTGTCCTTGGGGGACAGATCTGGGGTCTACAGGTGGCTCACACCTGTAATCCT
AGCACTTTGGGAAGCCAAGATGGGAGGATCACTTGAGGCCAGGAGCTTAAGACCATCCTGGGCAACATGGCGAGACCTCGTCTCTATAAA
AACAGTAAAAATTAGCGTGGAGTGGTGGTAAGTGCCTGTAGTCCCAGCTACTCGGGAGACTGAGGTGGGAGGATCACTTGAGCCCAGGGG
ATTTAGGCTGCAGTGGAGCGGTGATCAGGCCATTCCACTCCAGCCTGGGTGACAGAGTGAGGCCCTGTCTCAAAAAAAAAAAAAACAAAA
ACAAAAACAAACCACACCTGCATCTGCTGTGCTGGGCCCCCGGTTCTCTTTTCCCTCTGGGATCTAAGATGCCGCTGGGGATCCAAGGCA
GAGGCCTGGGAGCCCCCATTTCCGAGGGGGAGGGCTAGCGTGGAAGGCCCCGCCCCGGCAGCTGCGGAGGGATTTGGTGGGGTCCAGGCC
GCCCTTGCCACGCAGGGGTGCGCGGATGACCTGAAAAAAGCCAGAAAGAGGAAAGGTGCCGCCGAGGCTGGTCGCTCTCAGCTGGGGCTC
ATCGCATCCTCTACCAAGAGCGCTCCCACCACACAGGTCCCGCCCCTCCCAGCAAAGCTTCTGGCGCCGCCCTGTCTGAACCTGGAGCGG
CTGGGAGGATCCCCCTCCCAGGAGAAGCCGAGGACCCCAGGATGCTGCAGAATCAGTGAGAGGTCCCTCTGGCCTGCATGCCAGGAGTCG
GTCACCGCCCTGTGCTTCCTCCAAGAGACAGTGGAGAGGCTGGGGATTCCAAGGACACACAGACCAGGATCAGCCAAAAGGGCCGCCGTC
TGCAGCCCCCGGGGACTCCCTCGGCCCCACCCCAGAGAAGGCCCCGGAAACAGCTGAACCCCTGCCGGGGCACCGAGAGAGTGGACCCTG
GGTTCGAGGGGGTGACTCTGAAGTTTCAGATAAAGCCGGACTCCAGCCTGCAGATCATCCCCACGTACAGCCTGCCCTGCAGTAGCCGTT
CTCAGGAATCCCCTGCAGATGCTGTTGGGGGCCCTGCAGCCCACCCAGGAGGCACCGAGGCCCACTCAGCAGGCAGCGAGGCCCTGGAGC

>23695_23695_2_DNMT1-FDX1L_DNMT1_chr19_10283766_ENST00000340748_FDX1L_chr19_10426435_ENST00000541276_length(amino acids)=323AA_BP=304
MGMAGSVPSFCTGYRLSPFGTSPPPPRPDWGGRRRLRSSPLPIGFRAKSRGACAAAAASAEASEMPARTAPARVPTLAVPAISLPDDVRR
RLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNREVNGRLENGNQARSE
ARRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDEKRRR

--------------------------------------------------------------
>23695_23695_3_DNMT1-FDX1L_DNMT1_chr19_10283766_ENST00000359526_FDX1L_chr19_10421616_ENST00000541276_length(transcript)=2584nt_BP=948nt
GGCTCCGTTCCATCCTTCTGCACAGGGTATCGCCTCTCTCCGTTTGGTACATCCCCTCCTCCCCCACGCCCGGACTGGGGTGGTAGACGC
CGCCTCCGCTCATCGCCCCTCCCCATCGGTTTCCGCGCGAAAAGCCGGGGCGCCTGCGCTGCCGCCGCCGCGTCTGCTGAAGCCTCCGAG
ATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCACACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGAT
TTGGAAAGAGACAGCTTAACAGAAAAGGAATGTGTGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAG
TTATGTGACTTGGAAACCAAATTACGTAAAGAAGAATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTG
TCCTTGGAGAACGGTGCTCATGCTTACAACCGGGAAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTG
GGAATGGCAGATGCCAACAGCCCCCCCAAACCCCTTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCGTTCA
AGAGACCCTCCTGCCTCAGCCTCCCAAGTAACTGGGATTAGAGCTGAACCTTCACCTAGCCCCAGGATTACAAGGAAAAGCACCAGGCAA
ACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCTCAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGTCCATCAAG
GAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGAGAACGAGTTGCTAGACCGCTTCCTGCAGAAGAACCTGAAAGA
GCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAAGGGCCTGTGAAGCCTCCCTGGCCTGCTCCACCTGCCATGTGT
ATGTGAGTGAAGACCACCTGGATCTCCTGCCTCCTCCCGAGGAGAGGAGAACTCGCGGCTGGGCTGCCAGATTGTGCTGACACCGGAGCT
GGAAGGAGCGGAATTCACCCTGCCCAAGATCACCAGGAACTTCTACGTGGATGGCCATGTCCCCAAGCCCCACTGACATGAACACCTGGA
CCATTCCACATTGCCATGGCCCCAGGGCCCAGATTGAGGGAATAGCCAGGTGCCAGCCCTGCCCAGAGTGCGGACAGGCCCGGGAGAGAC
GTGGAAGCCCCTGTGAAGGACAACACCCCTGCTTGGGAGAGAGTCCCATGTCCAGGCCCCTGAGAATCAGGGTTTGAGTAGGAGTGGACT
CATATTGGAGCTGCAATAAATCGATAACACAGGCCCCAGCATGTTGAGTGTCCTTGGGGGACAGATCTGGGGTCTACAGGTGGCTCACAC
CTGTAATCCTAGCACTTTGGGAAGCCAAGATGGGAGGATCACTTGAGGCCAGGAGCTTAAGACCATCCTGGGCAACATGGCGAGACCTCG
TCTCTATAAAAACAGTAAAAATTAGCGTGGAGTGGTGGTAAGTGCCTGTAGTCCCAGCTACTCGGGAGACTGAGGTGGGAGGATCACTTG
AGCCCAGGGGATTTAGGCTGCAGTGGAGCGGTGATCAGGCCATTCCACTCCAGCCTGGGTGACAGAGTGAGGCCCTGTCTCAAAAAAAAA
AAAAACAAAAACAAAAACAAACCACACCTGCATCTGCTGTGCTGGGCCCCCGGTTCTCTTTTCCCTCTGGGATCTAAGATGCCGCTGGGG
ATCCAAGGCAGAGGCCTGGGAGCCCCCATTTCCGAGGGGGAGGGCTAGCGTGGAAGGCCCCGCCCCGGCAGCTGCGGAGGGATTTGGTGG
GGTCCAGGCCGCCCTTGCCACGCAGGGGTGCGCGGATGACCTGAAAAAAGCCAGAAAGAGGAAAGGTGCCGCCGAGGCTGGTCGCTCTCA
GCTGGGGCTCATCGCATCCTCTACCAAGAGCGCTCCCACCACACAGGTCCCGCCCCTCCCAGCAAAGCTTCTGGCGCCGCCCTGTCTGAA
CCTGGAGCGGCTGGGAGGATCCCCCTCCCAGGAGAAGCCGAGGACCCCAGGATGCTGCAGAATCAGTGAGAGGTCCCTCTGGCCTGCATG
CCAGGAGTCGGTCACCGCCCTGTGCTTCCTCCAAGAGACAGTGGAGAGGCTGGGGATTCCAAGGACACACAGACCAGGATCAGCCAAAAG
GGCCGCCGTCTGCAGCCCCCGGGGACTCCCTCGGCCCCACCCCAGAGAAGGCCCCGGAAACAGCTGAACCCCTGCCGGGGCACCGAGAGA
GTGGACCCTGGGTTCGAGGGGGTGACTCTGAAGTTTCAGATAAAGCCGGACTCCAGCCTGCAGATCATCCCCACGTACAGCCTGCCCTGC
AGTAGCCGTTCTCAGGAATCCCCTGCAGATGCTGTTGGGGGCCCTGCAGCCCACCCAGGAGGCACCGAGGCCCACTCAGCAGGCAGCGAG

>23695_23695_3_DNMT1-FDX1L_DNMT1_chr19_10283766_ENST00000359526_FDX1L_chr19_10421616_ENST00000541276_length(amino acids)=271AA_BP=256
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDL
SLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKRSRDPPASASQVTGIRAEPSPSPRITRKSTRQ
TTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERAKSGTRTEKEEERDEKGPVKPPWPAPPAMC

--------------------------------------------------------------
>23695_23695_4_DNMT1-FDX1L_DNMT1_chr19_10283766_ENST00000359526_FDX1L_chr19_10426435_ENST00000541276_length(transcript)=2746nt_BP=948nt
GGCTCCGTTCCATCCTTCTGCACAGGGTATCGCCTCTCTCCGTTTGGTACATCCCCTCCTCCCCCACGCCCGGACTGGGGTGGTAGACGC
CGCCTCCGCTCATCGCCCCTCCCCATCGGTTTCCGCGCGAAAAGCCGGGGCGCCTGCGCTGCCGCCGCCGCGTCTGCTGAAGCCTCCGAG
ATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCACACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGAT
TTGGAAAGAGACAGCTTAACAGAAAAGGAATGTGTGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAG
TTATGTGACTTGGAAACCAAATTACGTAAAGAAGAATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTG
TCCTTGGAGAACGGTGCTCATGCTTACAACCGGGAAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTG
GGAATGGCAGATGCCAACAGCCCCCCCAAACCCCTTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCGTTCA
AGAGACCCTCCTGCCTCAGCCTCCCAAGTAACTGGGATTAGAGCTGAACCTTCACCTAGCCCCAGGATTACAAGGAAAAGCACCAGGCAA
ACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCTCAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGTCCATCAAG
GAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGAGAACGAGTTGCTAGACCGCTTCCTGCAGAAGAACCTGAAAGA
GCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAAGCTCGCGCCCGGCTGGAGAGGAGGACGCGGGCGGCCCGGAGC
GGCCCGGGGACGTGGTGAACGTGGTGTTCGTAGACCGCTCAGGCCAGCGGATCCCAGTGAGTGGCAGAGTCGGGGACAATGTTCTTCACC
TGGCCCAGCGCCACGGGGTGGACCTGGAAGGGGCCTGTGAAGCCTCCCTGGCCTGCTCCACCTGCCATGTGTATGTGAGTGAAGACCACC
TGGATCTCCTGCCTCCTCCCGAGGAGAGGAGAACTCGCGGCTGGGCTGCCAGATTGTGCTGACACCGGAGCTGGAAGGAGCGGAATTCAC
CCTGCCCAAGATCACCAGGAACTTCTACGTGGATGGCCATGTCCCCAAGCCCCACTGACATGAACACCTGGACCATTCCACATTGCCATG
GCCCCAGGGCCCAGATTGAGGGAATAGCCAGGTGCCAGCCCTGCCCAGAGTGCGGACAGGCCCGGGAGAGACGTGGAAGCCCCTGTGAAG
GACAACACCCCTGCTTGGGAGAGAGTCCCATGTCCAGGCCCCTGAGAATCAGGGTTTGAGTAGGAGTGGACTCATATTGGAGCTGCAATA
AATCGATAACACAGGCCCCAGCATGTTGAGTGTCCTTGGGGGACAGATCTGGGGTCTACAGGTGGCTCACACCTGTAATCCTAGCACTTT
GGGAAGCCAAGATGGGAGGATCACTTGAGGCCAGGAGCTTAAGACCATCCTGGGCAACATGGCGAGACCTCGTCTCTATAAAAACAGTAA
AAATTAGCGTGGAGTGGTGGTAAGTGCCTGTAGTCCCAGCTACTCGGGAGACTGAGGTGGGAGGATCACTTGAGCCCAGGGGATTTAGGC
TGCAGTGGAGCGGTGATCAGGCCATTCCACTCCAGCCTGGGTGACAGAGTGAGGCCCTGTCTCAAAAAAAAAAAAAACAAAAACAAAAAC
AAACCACACCTGCATCTGCTGTGCTGGGCCCCCGGTTCTCTTTTCCCTCTGGGATCTAAGATGCCGCTGGGGATCCAAGGCAGAGGCCTG
GGAGCCCCCATTTCCGAGGGGGAGGGCTAGCGTGGAAGGCCCCGCCCCGGCAGCTGCGGAGGGATTTGGTGGGGTCCAGGCCGCCCTTGC
CACGCAGGGGTGCGCGGATGACCTGAAAAAAGCCAGAAAGAGGAAAGGTGCCGCCGAGGCTGGTCGCTCTCAGCTGGGGCTCATCGCATC
CTCTACCAAGAGCGCTCCCACCACACAGGTCCCGCCCCTCCCAGCAAAGCTTCTGGCGCCGCCCTGTCTGAACCTGGAGCGGCTGGGAGG
ATCCCCCTCCCAGGAGAAGCCGAGGACCCCAGGATGCTGCAGAATCAGTGAGAGGTCCCTCTGGCCTGCATGCCAGGAGTCGGTCACCGC
CCTGTGCTTCCTCCAAGAGACAGTGGAGAGGCTGGGGATTCCAAGGACACACAGACCAGGATCAGCCAAAAGGGCCGCCGTCTGCAGCCC
CCGGGGACTCCCTCGGCCCCACCCCAGAGAAGGCCCCGGAAACAGCTGAACCCCTGCCGGGGCACCGAGAGAGTGGACCCTGGGTTCGAG
GGGGTGACTCTGAAGTTTCAGATAAAGCCGGACTCCAGCCTGCAGATCATCCCCACGTACAGCCTGCCCTGCAGTAGCCGTTCTCAGGAA
TCCCCTGCAGATGCTGTTGGGGGCCCTGCAGCCCACCCAGGAGGCACCGAGGCCCACTCAGCAGGCAGCGAGGCCCTGGAGCCCCGGCGC

>23695_23695_4_DNMT1-FDX1L_DNMT1_chr19_10283766_ENST00000359526_FDX1L_chr19_10426435_ENST00000541276_length(amino acids)=275AA_BP=256
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDL
SLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKRSRDPPASASQVTGIRAEPSPSPRITRKSTRQ
TTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERAKSGTRTEKEEERDEKARARLERRTRAARS

--------------------------------------------------------------
>23695_23695_5_DNMT1-FDX1L_DNMT1_chr19_10283766_ENST00000540357_FDX1L_chr19_10421616_ENST00000541276_length(transcript)=2536nt_BP=900nt
GGCTCCGTTCCATCCTTCTGCACAGGGTATCGCCTCTCTCCGTTTGGTACATCCCCTCCTCCCCCACGCCCGGACTGGGGTGGTAGACGC
CGCCTCCGCTCATCGCCCCTCCCCATCGGTTTCCGCGCGAAAAGCCGGGGCGCCTGCGCTGCCGCCGCCGCGTCTGCTGAAGCCTCCGAG
ATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCACACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGAT
TTGGAAAGAGACAGCTTAACAGAAAAGGAATGTGTGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAG
TTATGTGACTTGGAAACCAAATTACGTAAAGAAGAATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTG
TCCTTGGAGAACGGTGCTCATGCTTACAACCGGGAAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTG
GGAATGGCAGATGCCAACAGCCCCCCCAAACCCCTTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCCTGAA
CCTTCACCTAGCCCCAGGATTACAAGGAAAAGCACCAGGCAAACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCT
CAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGTCCATCAAGGAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGA
GAACGAGTTGCTAGACCGCTTCCTGCAGAAGAACCTGAAAGAGCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAA
GGGCCTGTGAAGCCTCCCTGGCCTGCTCCACCTGCCATGTGTATGTGAGTGAAGACCACCTGGATCTCCTGCCTCCTCCCGAGGAGAGGA
GAACTCGCGGCTGGGCTGCCAGATTGTGCTGACACCGGAGCTGGAAGGAGCGGAATTCACCCTGCCCAAGATCACCAGGAACTTCTACGT
GGATGGCCATGTCCCCAAGCCCCACTGACATGAACACCTGGACCATTCCACATTGCCATGGCCCCAGGGCCCAGATTGAGGGAATAGCCA
GGTGCCAGCCCTGCCCAGAGTGCGGACAGGCCCGGGAGAGACGTGGAAGCCCCTGTGAAGGACAACACCCCTGCTTGGGAGAGAGTCCCA
TGTCCAGGCCCCTGAGAATCAGGGTTTGAGTAGGAGTGGACTCATATTGGAGCTGCAATAAATCGATAACACAGGCCCCAGCATGTTGAG
TGTCCTTGGGGGACAGATCTGGGGTCTACAGGTGGCTCACACCTGTAATCCTAGCACTTTGGGAAGCCAAGATGGGAGGATCACTTGAGG
CCAGGAGCTTAAGACCATCCTGGGCAACATGGCGAGACCTCGTCTCTATAAAAACAGTAAAAATTAGCGTGGAGTGGTGGTAAGTGCCTG
TAGTCCCAGCTACTCGGGAGACTGAGGTGGGAGGATCACTTGAGCCCAGGGGATTTAGGCTGCAGTGGAGCGGTGATCAGGCCATTCCAC
TCCAGCCTGGGTGACAGAGTGAGGCCCTGTCTCAAAAAAAAAAAAAACAAAAACAAAAACAAACCACACCTGCATCTGCTGTGCTGGGCC
CCCGGTTCTCTTTTCCCTCTGGGATCTAAGATGCCGCTGGGGATCCAAGGCAGAGGCCTGGGAGCCCCCATTTCCGAGGGGGAGGGCTAG
CGTGGAAGGCCCCGCCCCGGCAGCTGCGGAGGGATTTGGTGGGGTCCAGGCCGCCCTTGCCACGCAGGGGTGCGCGGATGACCTGAAAAA
AGCCAGAAAGAGGAAAGGTGCCGCCGAGGCTGGTCGCTCTCAGCTGGGGCTCATCGCATCCTCTACCAAGAGCGCTCCCACCACACAGGT
CCCGCCCCTCCCAGCAAAGCTTCTGGCGCCGCCCTGTCTGAACCTGGAGCGGCTGGGAGGATCCCCCTCCCAGGAGAAGCCGAGGACCCC
AGGATGCTGCAGAATCAGTGAGAGGTCCCTCTGGCCTGCATGCCAGGAGTCGGTCACCGCCCTGTGCTTCCTCCAAGAGACAGTGGAGAG
GCTGGGGATTCCAAGGACACACAGACCAGGATCAGCCAAAAGGGCCGCCGTCTGCAGCCCCCGGGGACTCCCTCGGCCCCACCCCAGAGA
AGGCCCCGGAAACAGCTGAACCCCTGCCGGGGCACCGAGAGAGTGGACCCTGGGTTCGAGGGGGTGACTCTGAAGTTTCAGATAAAGCCG
GACTCCAGCCTGCAGATCATCCCCACGTACAGCCTGCCCTGCAGTAGCCGTTCTCAGGAATCCCCTGCAGATGCTGTTGGGGGCCCTGCA
GCCCACCCAGGAGGCACCGAGGCCCACTCAGCAGGCAGCGAGGCCCTGGAGCCCCGGCGCTGTGCTTCCTGTCGGACCCAGAGGACCCCG

>23695_23695_5_DNMT1-FDX1L_DNMT1_chr19_10283766_ENST00000540357_FDX1L_chr19_10421616_ENST00000541276_length(amino acids)=255AA_BP=240
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDL
SLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKP

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>23695_23695_6_DNMT1-FDX1L_DNMT1_chr19_10283766_ENST00000540357_FDX1L_chr19_10426435_ENST00000541276_length(transcript)=2698nt_BP=900nt
GGCTCCGTTCCATCCTTCTGCACAGGGTATCGCCTCTCTCCGTTTGGTACATCCCCTCCTCCCCCACGCCCGGACTGGGGTGGTAGACGC
CGCCTCCGCTCATCGCCCCTCCCCATCGGTTTCCGCGCGAAAAGCCGGGGCGCCTGCGCTGCCGCCGCCGCGTCTGCTGAAGCCTCCGAG
ATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCACACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGAT
TTGGAAAGAGACAGCTTAACAGAAAAGGAATGTGTGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAG
TTATGTGACTTGGAAACCAAATTACGTAAAGAAGAATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTG
TCCTTGGAGAACGGTGCTCATGCTTACAACCGGGAAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTG
GGAATGGCAGATGCCAACAGCCCCCCCAAACCCCTTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCCTGAA
CCTTCACCTAGCCCCAGGATTACAAGGAAAAGCACCAGGCAAACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCT
CAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGTCCATCAAGGAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGA
GAACGAGTTGCTAGACCGCTTCCTGCAGAAGAACCTGAAAGAGCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAA
GCTCGCGCCCGGCTGGAGAGGAGGACGCGGGCGGCCCGGAGCGGCCCGGGGACGTGGTGAACGTGGTGTTCGTAGACCGCTCAGGCCAGC
GGATCCCAGTGAGTGGCAGAGTCGGGGACAATGTTCTTCACCTGGCCCAGCGCCACGGGGTGGACCTGGAAGGGGCCTGTGAAGCCTCCC
TGGCCTGCTCCACCTGCCATGTGTATGTGAGTGAAGACCACCTGGATCTCCTGCCTCCTCCCGAGGAGAGGAGAACTCGCGGCTGGGCTG
CCAGATTGTGCTGACACCGGAGCTGGAAGGAGCGGAATTCACCCTGCCCAAGATCACCAGGAACTTCTACGTGGATGGCCATGTCCCCAA
GCCCCACTGACATGAACACCTGGACCATTCCACATTGCCATGGCCCCAGGGCCCAGATTGAGGGAATAGCCAGGTGCCAGCCCTGCCCAG
AGTGCGGACAGGCCCGGGAGAGACGTGGAAGCCCCTGTGAAGGACAACACCCCTGCTTGGGAGAGAGTCCCATGTCCAGGCCCCTGAGAA
TCAGGGTTTGAGTAGGAGTGGACTCATATTGGAGCTGCAATAAATCGATAACACAGGCCCCAGCATGTTGAGTGTCCTTGGGGGACAGAT
CTGGGGTCTACAGGTGGCTCACACCTGTAATCCTAGCACTTTGGGAAGCCAAGATGGGAGGATCACTTGAGGCCAGGAGCTTAAGACCAT
CCTGGGCAACATGGCGAGACCTCGTCTCTATAAAAACAGTAAAAATTAGCGTGGAGTGGTGGTAAGTGCCTGTAGTCCCAGCTACTCGGG
AGACTGAGGTGGGAGGATCACTTGAGCCCAGGGGATTTAGGCTGCAGTGGAGCGGTGATCAGGCCATTCCACTCCAGCCTGGGTGACAGA
GTGAGGCCCTGTCTCAAAAAAAAAAAAAACAAAAACAAAAACAAACCACACCTGCATCTGCTGTGCTGGGCCCCCGGTTCTCTTTTCCCT
CTGGGATCTAAGATGCCGCTGGGGATCCAAGGCAGAGGCCTGGGAGCCCCCATTTCCGAGGGGGAGGGCTAGCGTGGAAGGCCCCGCCCC
GGCAGCTGCGGAGGGATTTGGTGGGGTCCAGGCCGCCCTTGCCACGCAGGGGTGCGCGGATGACCTGAAAAAAGCCAGAAAGAGGAAAGG
TGCCGCCGAGGCTGGTCGCTCTCAGCTGGGGCTCATCGCATCCTCTACCAAGAGCGCTCCCACCACACAGGTCCCGCCCCTCCCAGCAAA
GCTTCTGGCGCCGCCCTGTCTGAACCTGGAGCGGCTGGGAGGATCCCCCTCCCAGGAGAAGCCGAGGACCCCAGGATGCTGCAGAATCAG
TGAGAGGTCCCTCTGGCCTGCATGCCAGGAGTCGGTCACCGCCCTGTGCTTCCTCCAAGAGACAGTGGAGAGGCTGGGGATTCCAAGGAC
ACACAGACCAGGATCAGCCAAAAGGGCCGCCGTCTGCAGCCCCCGGGGACTCCCTCGGCCCCACCCCAGAGAAGGCCCCGGAAACAGCTG
AACCCCTGCCGGGGCACCGAGAGAGTGGACCCTGGGTTCGAGGGGGTGACTCTGAAGTTTCAGATAAAGCCGGACTCCAGCCTGCAGATC
ATCCCCACGTACAGCCTGCCCTGCAGTAGCCGTTCTCAGGAATCCCCTGCAGATGCTGTTGGGGGCCCTGCAGCCCACCCAGGAGGCACC

>23695_23695_6_DNMT1-FDX1L_DNMT1_chr19_10283766_ENST00000540357_FDX1L_chr19_10426435_ENST00000541276_length(amino acids)=259AA_BP=240
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDL
SLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKP

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Fusion Gene PPI Analysis for DNMT1-FDX1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401_120240.01617.0DMAP1
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411_120256.01633.0DMAP1
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401_120240.01617.0DMAP1
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411_120256.01633.0DMAP1
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401_148240.01617.0DNMT3A
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411_148256.01633.0DNMT3A
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401_148240.01617.0DNMT3A
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411_148256.01633.0DNMT3A
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-840149_217240.01617.0DNMT3B
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-941149_217256.01633.0DNMT3B
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-840149_217240.01617.0DNMT3B
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-941149_217256.01633.0DNMT3B
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-840163_174240.01617.0PCNA
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-941163_174256.01633.0PCNA
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-840163_174240.01617.0PCNA
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-941163_174256.01633.0PCNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-8401121_1616240.01617.0the PRC2/EED-EZH2 complex
HgeneDNMT1chr19:10283766chr19:10421616ENST00000340748-840308_606240.01617.0the PRC2/EED-EZH2 complex
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-9411121_1616256.01633.0the PRC2/EED-EZH2 complex
HgeneDNMT1chr19:10283766chr19:10421616ENST00000359526-941308_606256.01633.0the PRC2/EED-EZH2 complex
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-8401121_1616240.01617.0the PRC2/EED-EZH2 complex
HgeneDNMT1chr19:10283766chr19:10426435ENST00000340748-840308_606240.01617.0the PRC2/EED-EZH2 complex
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-9411121_1616256.01633.0the PRC2/EED-EZH2 complex
HgeneDNMT1chr19:10283766chr19:10426435ENST00000359526-941308_606256.01633.0the PRC2/EED-EZH2 complex


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DNMT1-FDX1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DNMT1-FDX1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource