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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DNMT1-ZNF563 (FusionGDB2 ID:23705)

Fusion Gene Summary for DNMT1-ZNF563

check button Fusion gene summary
Fusion gene informationFusion gene name: DNMT1-ZNF563
Fusion gene ID: 23705
HgeneTgene
Gene symbol

DNMT1

ZNF563

Gene ID

1786

147837

Gene nameDNA methyltransferase 1zinc finger protein 563
SynonymsADCADN|AIM|CXXC9|DNMT|HSN1E|MCMT|m.HsaI-
Cytomap

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
DescriptionDNA (cytosine-5)-methyltransferase 1CXXC-type zinc finger protein 9DNA (cytosine-5-)-methyltransferase 1DNA MTase HsaIDNA methyltransferase HsaIzinc finger protein 563
Modification date2020031320200313
UniProtAcc

P26358

.
Ensembl transtripts involved in fusion geneENST00000340748, ENST00000359526, 
ENST00000540357, ENST00000589538, 
ENST00000293725, ENST00000595977, 
Fusion gene scores* DoF score14 X 12 X 11=18481 X 1 X 1=1
# samples 171
** MAII scorelog2(17/1848*10)=-3.44235810527836
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: DNMT1 [Title/Abstract] AND ZNF563 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNMT1(10273343)-ZNF563(12433525), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNMT1

GO:0010216

maintenance of DNA methylation

18754681|21745816


check buttonFusion gene breakpoints across DNMT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF563 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HF-7134-01ADNMT1chr19

10273343

-ZNF563chr19

12433525

-


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Fusion Gene ORF analysis for DNMT1-ZNF563

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000340748ENST00000293725DNMT1chr19

10273343

-ZNF563chr19

12433525

-
In-frameENST00000340748ENST00000595977DNMT1chr19

10273343

-ZNF563chr19

12433525

-
In-frameENST00000359526ENST00000293725DNMT1chr19

10273343

-ZNF563chr19

12433525

-
In-frameENST00000359526ENST00000595977DNMT1chr19

10273343

-ZNF563chr19

12433525

-
In-frameENST00000540357ENST00000293725DNMT1chr19

10273343

-ZNF563chr19

12433525

-
In-frameENST00000540357ENST00000595977DNMT1chr19

10273343

-ZNF563chr19

12433525

-
intron-3CDSENST00000589538ENST00000293725DNMT1chr19

10273343

-ZNF563chr19

12433525

-
intron-3CDSENST00000589538ENST00000595977DNMT1chr19

10273343

-ZNF563chr19

12433525

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000340748DNMT1chr1910273343-ENST00000293725ZNF563chr1912433525-37411196442623859
ENST00000340748DNMT1chr1910273343-ENST00000595977ZNF563chr1912433525-19131196441882612
ENST00000540357DNMT1chr1910273343-ENST00000293725ZNF563chr1912433525-368511401802567795
ENST00000540357DNMT1chr1910273343-ENST00000595977ZNF563chr1912433525-185711401801826548
ENST00000359526DNMT1chr1910273343-ENST00000293725ZNF563chr1912433525-373311881802615811
ENST00000359526DNMT1chr1910273343-ENST00000595977ZNF563chr1912433525-190511881801874564

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000340748ENST00000293725DNMT1chr1910273343-ZNF563chr1912433525-0.0015441350.9984559
ENST00000340748ENST00000595977DNMT1chr1910273343-ZNF563chr1912433525-0.0079258340.99207413
ENST00000540357ENST00000293725DNMT1chr1910273343-ZNF563chr1912433525-0.0014951340.9985049
ENST00000540357ENST00000595977DNMT1chr1910273343-ZNF563chr1912433525-0.0083906590.9916093
ENST00000359526ENST00000293725DNMT1chr1910273343-ZNF563chr1912433525-0.0015643010.9984357
ENST00000359526ENST00000595977DNMT1chr1910273343-ZNF563chr1912433525-0.0068345530.99316543

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Fusion Genomic Features for DNMT1-ZNF563


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DNMT1-ZNF563


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:10273343/chr19:12433525)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNMT1

P26358

.
FUNCTION: Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-124016_1093201617.0DomainDMAP1-binding
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-134116_1093361633.0DomainDMAP1-binding
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-1240177_2053201617.0MotifNuclear localization signal
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-1341177_2053361633.0MotifNuclear localization signal
TgeneZNF563chr19:10273343chr19:12433525ENST00000293725044_961477.0DomainKRAB
TgeneZNF563chr19:10273343chr19:12433525ENST00000595977054_961230.0DomainKRAB
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504101_1251477.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504169_1911477.0Zinc fingerC2H2-type 2%3B degenerate
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504197_2191477.0Zinc fingerC2H2-type 3
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504225_2471477.0Zinc fingerC2H2-type 4
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504253_2751477.0Zinc fingerC2H2-type 5
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504281_3031477.0Zinc fingerC2H2-type 6
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504309_3311477.0Zinc fingerC2H2-type 7
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504337_3591477.0Zinc fingerC2H2-type 8
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504365_3871477.0Zinc fingerC2H2-type 9
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504393_4151477.0Zinc fingerC2H2-type 10
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504421_4431477.0Zinc fingerC2H2-type 11
TgeneZNF563chr19:10273343chr19:12433525ENST0000029372504449_4711477.0Zinc fingerC2H2-type 12
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705101_1251230.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705169_1911230.0Zinc fingerC2H2-type 2%3B degenerate
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705197_2191230.0Zinc fingerC2H2-type 3
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705225_2471230.0Zinc fingerC2H2-type 4
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705253_2751230.0Zinc fingerC2H2-type 5
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705281_3031230.0Zinc fingerC2H2-type 6
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705309_3311230.0Zinc fingerC2H2-type 7
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705337_3591230.0Zinc fingerC2H2-type 8
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705365_3871230.0Zinc fingerC2H2-type 9
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705393_4151230.0Zinc fingerC2H2-type 10
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705421_4431230.0Zinc fingerC2H2-type 11
TgeneZNF563chr19:10273343chr19:12433525ENST0000059597705449_4711230.0Zinc fingerC2H2-type 12

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401139_15993201617.0DomainSAM-dependent MTase C5-type
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-1240755_8803201617.0DomainBAH 1
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-1240972_11003201617.0DomainBAH 2
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411139_15993361633.0DomainSAM-dependent MTase C5-type
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-1341755_8803361633.0DomainBAH 1
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-1341972_11003361633.0DomainBAH 2
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401109_11203201617.0RegionNote=6 X 2 AA tandem repeats of K-G
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401139_16163201617.0RegionNote=Catalytic
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401150_11513201617.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401168_11693201617.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401190_11913201617.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-1240310_5023201617.0RegionNote=Homodimerization
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-1240331_5503201617.0RegionDNA replication foci-targeting sequence
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-1240651_6973201617.0RegionNote=Required for activity
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-1240693_7543201617.0RegionNote=Autoinhibitory linker
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411109_11203361633.0RegionNote=6 X 2 AA tandem repeats of K-G
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411139_16163361633.0RegionNote=Catalytic
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411150_11513361633.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411168_11693361633.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411190_11913361633.0RegionS-adenosyl-L-methionine binding
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-1341310_5023361633.0RegionNote=Homodimerization
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-1341331_5503361633.0RegionDNA replication foci-targeting sequence
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-1341651_6973361633.0RegionNote=Required for activity
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-1341693_7543361633.0RegionNote=Autoinhibitory linker
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401109_11103201617.0RepeatNote=1
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401111_11123201617.0RepeatNote=2
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401113_11143201617.0RepeatNote=3
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401115_11163201617.0RepeatNote=4
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401117_11183201617.0RepeatNote=5
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401119_11203201617.0RepeatNote=6%3B approximate
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411109_11103361633.0RepeatNote=1
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411111_11123361633.0RepeatNote=2
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411113_11143361633.0RepeatNote=3
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411115_11163361633.0RepeatNote=4
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411117_11183361633.0RepeatNote=5
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411119_11203361633.0RepeatNote=6%3B approximate
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-1240646_6923201617.0Zinc fingerCXXC-type
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-1341646_6923361633.0Zinc fingerCXXC-type


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Fusion Gene Sequence for DNMT1-ZNF563


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>23705_23705_1_DNMT1-ZNF563_DNMT1_chr19_10273343_ENST00000340748_ZNF563_chr19_12433525_ENST00000293725_length(transcript)=3741nt_BP=1196nt
TCCGCGTGGGGGGGGTGTGTGCCCGCCTTGCGCATGCGTGTTCCCTGGGCATGGCCGGCTCCGTTCCATCCTTCTGCACAGGGTATCGCC
TCTCTCCGTTTGGTACATCCCCTCCTCCCCCACGCCCGGACTGGGGTGGTAGACGCCGCCTCCGCTCATCGCCCCTCCCCATCGGTTTCC
GCGCGAAAAGCCGGGGCGCCTGCGCTGCCGCCGCCGCGTCTGCTGAAGCCTCCGAGATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCA
CACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGATTTGGAAAGAGACAGCTTAACAGAAAAGGAATGTG
TGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAGTTATGTGACTTGGAAACCAAATTACGTAAAGAAG
AATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTGTCCTTGGAGAACGGTGCTCATGCTTACAACCGGG
AAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTGGGAATGGCAGATGCCAACAGCCCCCCCAAACCCC
TTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCCTGAACCTTCACCTAGCCCCAGGATTACAAGGAAAAGCA
CCAGGCAAACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCTCAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGT
CCATCAAGGAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGAGAACGAGTTGCTAGACCGCTTCCTGCAGAAGAAC
CTGAAAGAGCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAAGAAGAAAAGAGACTCCGAAGTCAAACCAAAGAAC
CAACACCCAAACAGAAACTGAAGGAGGAGCCGGACAGAGAAGCCAGGGCAGGCGTGCAGGCTGACGAGGACGAAGATGGAGACGAGAAAG
ATGAGAAGAAGCACAGAAGTCAACCCAAAGATCTAGCTGCCAAACGGAGGCCCGAAGAAAAAGAACCTGAAAAAGTAAATCCACAGATTT
CTGATGAAAAAGACGAGGATGAAAAGGACGCAGTGGCCTTTGAGGATGTGGCTGTGAACTTCACCCAGGAGGAATGGGCTTTGCTGGGTC
CATCACAGAAGAATTTATACAGATATGTGATGCAAGAAACCATCAGGAACCTGGACTGTATAAGAATGATATGGGAAGAACAGAATACTG
AAGATCAGTACAAAAATCCTAGGAGAAATCTAAGATGTCATATGGTAGAGAGATTCAGTGAAAGTAAAGACAGTAGTCAGTGTGGAGAAA
CATTTAGCCTCATTCGAGATAGTATTGTGAACAACAGCATTTGTCCTGGAGAAGATCCATGTCAAAGCGCTGAGTGTGAAGAAGTCATAA
TGGGTCATTTATCCCTTAATAGCCACATCAGAGTTGATTCTGGACACAAACCACATGAGTATCAGGAATATGGAGAGAAGCCACATACAC
ATAAACAACGTGGGAAAGCCTTCAGTTACCATCACTCCTTTCAGTCGCGTGGAAGGCCTCACACTGGAAAGAAACGCTATGAGTGTAAGG
AATGTGGAAAAACCTTCAGTTCTCGTAGAAACCTTCGAAGACACATGGTAGTGCAAGGTGGAAATAGACCTTATAAATGTAAGTTGTGTG
GGAAAGCTTTTTTTTGGCCCAGTTTATTACGTATGCATGAAAGAACTCACACTGGAGAGAAACCGTATGAATGTAAGCAGTGTTCTAAAG
CCTTTCCTTTTTACAGTTCCTATCGAAGACATGAGAGAATGCACACTGGGGAGAAACCGTATGAATGTAAGCAGTGTTCTAAAGCCTTGC
CTGATTCCAGTTCCTATATAAGACATGAAAGAACTCACACTGGAGAGAAACCATATACATGTAAACAGTGTGGGAAAGCCTTCAGTGTTT
CCAGTTCCCTTCGAAGACATGAAACCACTCACAGTGCAGAGAAACCCTATGAGTGTAAGCAATGCGGGAAAACATTTCATCATCTTGGAA
GCTTTCAGATACACATGAAAAGGCACACTGGAGATCGACCTCATAAATGTAAGATATGTGGGAAAGGCTTTGATCGTCCCAGTTTAGTTC
GATATCATGAACGAATTCACACTGGAGAGAAACCCTATGAATGCAAGCAGTGTGGGAAAACGTTATCTCATAGCTCAAGCTTTCGAAGAC
ACATGATAATGCACACTGGAGGTGGACCTCATAAATGCAAGATATGTGGGAAAGCTTTTGTTTATCCTAGTGTATGTCAAAGACACGAAA
AGTCTCACAGTGGAGAGAAACCCTATGAATGCAAGCAGTGTGGGAAAGCGTTATCTCATAGCTCAAGCTTTCGAAGACATATGGTAATGC
ATACGGGAGATGGGCCGAATAAATGCAAGGTATGTGGGAAAGCCTTTGTTTATCCCAGTGTATGTCAAAGACATGAAAAGACTCACTGGA
GAGAAACAATATGAATGTAAACTATTATAAAGCCTTCTATATTTCCAGTTCCCTTTGATATCATGAATAAACTTACACTGGACAGAAACC
CTATAAATGTAAATGTGGGAAAGCCTTTCATAATTTTTATTCCTTTCAAAATCATGAAATATCTCACACTGGAGAGATGCTGTATGATAT
AAGGAATGTGGGAAAGTGATCGATTTTTTTTTAACACCATTGTCAACATAAAACAACTCACAGAGCAGAAAAACTCTGTGAGTGTAAAAT
ATGTAGGGAAGCCTTCAGTCATTTTGGTAACTTAAAAGTACATGAGGCTGGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTAGGGTG
GGCAAATTGCTTGACCTCAGGAATTTGAGGCCTGCCTGGGCAAAATGGTGAAACCATGTCTCTACAAAAAATAGAAAAAGTAGCAGGTGT
GGTGGTATGCCCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGTGGGAAGATCTCTTGAGCCCAAGGGGTGGGGGTTGCAGTGAGCCAAGA
TGCACTGCACCCCAGCCTGGGCGACAGAGCCAGACCCTGTCTCAAAAAAAAAAAAAAAGTACATGAAAGGATTCACTCTGGAGAGAAGTC
ATATGAATGTAAGAAATGTAGAAAAGCATTGAGTTCTCTCAGGTCCTTGCATAGACATAAAAGGACTCACTGGAGAGATACTCTATAAAT
GTGTGAAATGTAGGGAAGTATTCTTTAATGTTATTTCATTTCAGATAGAAATAATTCTCATTGGAGATAAACCCTATGAATGTAAACACA
TAGTAAAGCCTTAATTTTAAGCCTCAGTTTCTTTCAAATACAGTTATCCCCTAATATTTGCAGGAGCGTGGTTCTACCACCCCCTGGGCA
TACATAAATCGACACATGCCAAGTCCTTTTTTAAAAATGACATATTTGGTACAAAATTACCCGGATGTGATGGCACATGCCTGTAATCCC
AGCTACTCAGGAGGCTGAGGCAGGATAATCACTTGAATCCGGGAGGCGGAGGTTGCGGTGAGCCAAGATCGCGCCACTGCACTCCAGCCT

>23705_23705_1_DNMT1-ZNF563_DNMT1_chr19_10273343_ENST00000340748_ZNF563_chr19_12433525_ENST00000293725_length(amino acids)=859AA_BP=386
MGMAGSVPSFCTGYRLSPFGTSPPPPRPDWGGRRRLRSSPLPIGFRAKSRGACAAAAASAEASEMPARTAPARVPTLAVPAISLPDDVRR
RLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNREVNGRLENGNQARSE
ARRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDEKRRR
VTSRERVARPLPAEEPERAKSGTRTEKEEERDEKEEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQPKDLAAK
RRPEEKEPEKVNPQISDEKDEDEKDAVAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNLDCIRMIWEEQNTEDQYKNPRRNLRCHM
VERFSESKDSSQCGETFSLIRDSIVNNSICPGEDPCQSAECEEVIMGHLSLNSHIRVDSGHKPHEYQEYGEKPHTHKQRGKAFSYHHSFQ
SRGRPHTGKKRYECKECGKTFSSRRNLRRHMVVQGGNRPYKCKLCGKAFFWPSLLRMHERTHTGEKPYECKQCSKAFPFYSSYRRHERMH
TGEKPYECKQCSKALPDSSSYIRHERTHTGEKPYTCKQCGKAFSVSSSLRRHETTHSAEKPYECKQCGKTFHHLGSFQIHMKRHTGDRPH
KCKICGKGFDRPSLVRYHERIHTGEKPYECKQCGKTLSHSSSFRRHMIMHTGGGPHKCKICGKAFVYPSVCQRHEKSHSGEKPYECKQCG

--------------------------------------------------------------
>23705_23705_2_DNMT1-ZNF563_DNMT1_chr19_10273343_ENST00000340748_ZNF563_chr19_12433525_ENST00000595977_length(transcript)=1913nt_BP=1196nt
TCCGCGTGGGGGGGGTGTGTGCCCGCCTTGCGCATGCGTGTTCCCTGGGCATGGCCGGCTCCGTTCCATCCTTCTGCACAGGGTATCGCC
TCTCTCCGTTTGGTACATCCCCTCCTCCCCCACGCCCGGACTGGGGTGGTAGACGCCGCCTCCGCTCATCGCCCCTCCCCATCGGTTTCC
GCGCGAAAAGCCGGGGCGCCTGCGCTGCCGCCGCCGCGTCTGCTGAAGCCTCCGAGATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCA
CACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGATTTGGAAAGAGACAGCTTAACAGAAAAGGAATGTG
TGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAGTTATGTGACTTGGAAACCAAATTACGTAAAGAAG
AATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTGTCCTTGGAGAACGGTGCTCATGCTTACAACCGGG
AAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTGGGAATGGCAGATGCCAACAGCCCCCCCAAACCCC
TTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCCTGAACCTTCACCTAGCCCCAGGATTACAAGGAAAAGCA
CCAGGCAAACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCTCAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGT
CCATCAAGGAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGAGAACGAGTTGCTAGACCGCTTCCTGCAGAAGAAC
CTGAAAGAGCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAAGAAGAAAAGAGACTCCGAAGTCAAACCAAAGAAC
CAACACCCAAACAGAAACTGAAGGAGGAGCCGGACAGAGAAGCCAGGGCAGGCGTGCAGGCTGACGAGGACGAAGATGGAGACGAGAAAG
ATGAGAAGAAGCACAGAAGTCAACCCAAAGATCTAGCTGCCAAACGGAGGCCCGAAGAAAAAGAACCTGAAAAAGTAAATCCACAGATTT
CTGATGAAAAAGACGAGGATGAAAAGGACGCAGTGGCCTTTGAGGATGTGGCTGTGAACTTCACCCAGGAGGAATGGGCTTTGCTGGGTC
CATCACAGAAGAATTTATACAGATATGTGATGCAAGAAACCATCAGGAACCTGGACTGTATAAGAATGATATGGGAAGAACAGAATACTG
AAGATCAGTACAAAAATCCTAGGAGAAATCTAAGATGTCATATGGTAGAGAGATTCAGTGAAAGTAAAGACAGTAGTCAGTGTGGAGAAA
CATTTAGCCTCATTCGAGATAGTATTGTGAACAACAGCATTTGTCCTGGAGAAGATCCATGTCAAAGCGCTGAGTGTGAAGAAGTCATAA
TGGGTCATTTATCCCTTAATAGCCACATCAGAGTTGATTCTGGACACAAACCACATGAGTATCAGGAATATGGAGAGAAGCCACATACAC
ATAAACAACGTGGGAAAGCCTTCAGTTACCATCACTCCTTTCAGTCGCGTGGAAGGCCTCACACTGGAAAGAAACGCTATGAGTGTAAGG
AATGTGGAAAAACCTTCAGTTCTCGTAGAAACCTTCGAAGACACATGGTAGTGCAAGGTGGAAATAGACCTTATAAATTTCCTATCGAAG
ACATGAGAGAATGCACACTGGGGAGAAACCGTATGAATGTAAGCAGTGTTCTAAAGCCTTGCCTGATTCCAGTTCCTATATAAGACATGA

>23705_23705_2_DNMT1-ZNF563_DNMT1_chr19_10273343_ENST00000340748_ZNF563_chr19_12433525_ENST00000595977_length(amino acids)=612AA_BP=389
MGMAGSVPSFCTGYRLSPFGTSPPPPRPDWGGRRRLRSSPLPIGFRAKSRGACAAAAASAEASEMPARTAPARVPTLAVPAISLPDDVRR
RLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNREVNGRLENGNQARSE
ARRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDEKRRR
VTSRERVARPLPAEEPERAKSGTRTEKEEERDEKEEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQPKDLAAK
RRPEEKEPEKVNPQISDEKDEDEKDAVAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNLDCIRMIWEEQNTEDQYKNPRRNLRCHM
VERFSESKDSSQCGETFSLIRDSIVNNSICPGEDPCQSAECEEVIMGHLSLNSHIRVDSGHKPHEYQEYGEKPHTHKQRGKAFSYHHSFQ

--------------------------------------------------------------
>23705_23705_3_DNMT1-ZNF563_DNMT1_chr19_10273343_ENST00000359526_ZNF563_chr19_12433525_ENST00000293725_length(transcript)=3733nt_BP=1188nt
GGCTCCGTTCCATCCTTCTGCACAGGGTATCGCCTCTCTCCGTTTGGTACATCCCCTCCTCCCCCACGCCCGGACTGGGGTGGTAGACGC
CGCCTCCGCTCATCGCCCCTCCCCATCGGTTTCCGCGCGAAAAGCCGGGGCGCCTGCGCTGCCGCCGCCGCGTCTGCTGAAGCCTCCGAG
ATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCACACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGAT
TTGGAAAGAGACAGCTTAACAGAAAAGGAATGTGTGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAG
TTATGTGACTTGGAAACCAAATTACGTAAAGAAGAATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTG
TCCTTGGAGAACGGTGCTCATGCTTACAACCGGGAAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTG
GGAATGGCAGATGCCAACAGCCCCCCCAAACCCCTTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCGTTCA
AGAGACCCTCCTGCCTCAGCCTCCCAAGTAACTGGGATTAGAGCTGAACCTTCACCTAGCCCCAGGATTACAAGGAAAAGCACCAGGCAA
ACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCTCAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGTCCATCAAG
GAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGAGAACGAGTTGCTAGACCGCTTCCTGCAGAAGAACCTGAAAGA
GCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAAGAAGAAAAGAGACTCCGAAGTCAAACCAAAGAACCAACACCC
AAACAGAAACTGAAGGAGGAGCCGGACAGAGAAGCCAGGGCAGGCGTGCAGGCTGACGAGGACGAAGATGGAGACGAGAAAGATGAGAAG
AAGCACAGAAGTCAACCCAAAGATCTAGCTGCCAAACGGAGGCCCGAAGAAAAAGAACCTGAAAAAGTAAATCCACAGATTTCTGATGAA
AAAGACGAGGATGAAAAGGACGCAGTGGCCTTTGAGGATGTGGCTGTGAACTTCACCCAGGAGGAATGGGCTTTGCTGGGTCCATCACAG
AAGAATTTATACAGATATGTGATGCAAGAAACCATCAGGAACCTGGACTGTATAAGAATGATATGGGAAGAACAGAATACTGAAGATCAG
TACAAAAATCCTAGGAGAAATCTAAGATGTCATATGGTAGAGAGATTCAGTGAAAGTAAAGACAGTAGTCAGTGTGGAGAAACATTTAGC
CTCATTCGAGATAGTATTGTGAACAACAGCATTTGTCCTGGAGAAGATCCATGTCAAAGCGCTGAGTGTGAAGAAGTCATAATGGGTCAT
TTATCCCTTAATAGCCACATCAGAGTTGATTCTGGACACAAACCACATGAGTATCAGGAATATGGAGAGAAGCCACATACACATAAACAA
CGTGGGAAAGCCTTCAGTTACCATCACTCCTTTCAGTCGCGTGGAAGGCCTCACACTGGAAAGAAACGCTATGAGTGTAAGGAATGTGGA
AAAACCTTCAGTTCTCGTAGAAACCTTCGAAGACACATGGTAGTGCAAGGTGGAAATAGACCTTATAAATGTAAGTTGTGTGGGAAAGCT
TTTTTTTGGCCCAGTTTATTACGTATGCATGAAAGAACTCACACTGGAGAGAAACCGTATGAATGTAAGCAGTGTTCTAAAGCCTTTCCT
TTTTACAGTTCCTATCGAAGACATGAGAGAATGCACACTGGGGAGAAACCGTATGAATGTAAGCAGTGTTCTAAAGCCTTGCCTGATTCC
AGTTCCTATATAAGACATGAAAGAACTCACACTGGAGAGAAACCATATACATGTAAACAGTGTGGGAAAGCCTTCAGTGTTTCCAGTTCC
CTTCGAAGACATGAAACCACTCACAGTGCAGAGAAACCCTATGAGTGTAAGCAATGCGGGAAAACATTTCATCATCTTGGAAGCTTTCAG
ATACACATGAAAAGGCACACTGGAGATCGACCTCATAAATGTAAGATATGTGGGAAAGGCTTTGATCGTCCCAGTTTAGTTCGATATCAT
GAACGAATTCACACTGGAGAGAAACCCTATGAATGCAAGCAGTGTGGGAAAACGTTATCTCATAGCTCAAGCTTTCGAAGACACATGATA
ATGCACACTGGAGGTGGACCTCATAAATGCAAGATATGTGGGAAAGCTTTTGTTTATCCTAGTGTATGTCAAAGACACGAAAAGTCTCAC
AGTGGAGAGAAACCCTATGAATGCAAGCAGTGTGGGAAAGCGTTATCTCATAGCTCAAGCTTTCGAAGACATATGGTAATGCATACGGGA
GATGGGCCGAATAAATGCAAGGTATGTGGGAAAGCCTTTGTTTATCCCAGTGTATGTCAAAGACATGAAAAGACTCACTGGAGAGAAACA
ATATGAATGTAAACTATTATAAAGCCTTCTATATTTCCAGTTCCCTTTGATATCATGAATAAACTTACACTGGACAGAAACCCTATAAAT
GTAAATGTGGGAAAGCCTTTCATAATTTTTATTCCTTTCAAAATCATGAAATATCTCACACTGGAGAGATGCTGTATGATATAAGGAATG
TGGGAAAGTGATCGATTTTTTTTTAACACCATTGTCAACATAAAACAACTCACAGAGCAGAAAAACTCTGTGAGTGTAAAATATGTAGGG
AAGCCTTCAGTCATTTTGGTAACTTAAAAGTACATGAGGCTGGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTAGGGTGGGCAAATT
GCTTGACCTCAGGAATTTGAGGCCTGCCTGGGCAAAATGGTGAAACCATGTCTCTACAAAAAATAGAAAAAGTAGCAGGTGTGGTGGTAT
GCCCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGTGGGAAGATCTCTTGAGCCCAAGGGGTGGGGGTTGCAGTGAGCCAAGATGCACTGC
ACCCCAGCCTGGGCGACAGAGCCAGACCCTGTCTCAAAAAAAAAAAAAAAGTACATGAAAGGATTCACTCTGGAGAGAAGTCATATGAAT
GTAAGAAATGTAGAAAAGCATTGAGTTCTCTCAGGTCCTTGCATAGACATAAAAGGACTCACTGGAGAGATACTCTATAAATGTGTGAAA
TGTAGGGAAGTATTCTTTAATGTTATTTCATTTCAGATAGAAATAATTCTCATTGGAGATAAACCCTATGAATGTAAACACATAGTAAAG
CCTTAATTTTAAGCCTCAGTTTCTTTCAAATACAGTTATCCCCTAATATTTGCAGGAGCGTGGTTCTACCACCCCCTGGGCATACATAAA
TCGACACATGCCAAGTCCTTTTTTAAAAATGACATATTTGGTACAAAATTACCCGGATGTGATGGCACATGCCTGTAATCCCAGCTACTC
AGGAGGCTGAGGCAGGATAATCACTTGAATCCGGGAGGCGGAGGTTGCGGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGCAGCA

>23705_23705_3_DNMT1-ZNF563_DNMT1_chr19_10273343_ENST00000359526_ZNF563_chr19_12433525_ENST00000293725_length(amino acids)=811AA_BP=338
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDL
SLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKRSRDPPASASQVTGIRAEPSPSPRITRKSTRQ
TTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERAKSGTRTEKEEERDEKEEKRLRSQTKEPTP
KQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQPKDLAAKRRPEEKEPEKVNPQISDEKDEDEKDAVAFEDVAVNFTQEEWALLGPSQ
KNLYRYVMQETIRNLDCIRMIWEEQNTEDQYKNPRRNLRCHMVERFSESKDSSQCGETFSLIRDSIVNNSICPGEDPCQSAECEEVIMGH
LSLNSHIRVDSGHKPHEYQEYGEKPHTHKQRGKAFSYHHSFQSRGRPHTGKKRYECKECGKTFSSRRNLRRHMVVQGGNRPYKCKLCGKA
FFWPSLLRMHERTHTGEKPYECKQCSKAFPFYSSYRRHERMHTGEKPYECKQCSKALPDSSSYIRHERTHTGEKPYTCKQCGKAFSVSSS
LRRHETTHSAEKPYECKQCGKTFHHLGSFQIHMKRHTGDRPHKCKICGKGFDRPSLVRYHERIHTGEKPYECKQCGKTLSHSSSFRRHMI
MHTGGGPHKCKICGKAFVYPSVCQRHEKSHSGEKPYECKQCGKALSHSSSFRRHMVMHTGDGPNKCKVCGKAFVYPSVCQRHEKTHWRET

--------------------------------------------------------------
>23705_23705_4_DNMT1-ZNF563_DNMT1_chr19_10273343_ENST00000359526_ZNF563_chr19_12433525_ENST00000595977_length(transcript)=1905nt_BP=1188nt
GGCTCCGTTCCATCCTTCTGCACAGGGTATCGCCTCTCTCCGTTTGGTACATCCCCTCCTCCCCCACGCCCGGACTGGGGTGGTAGACGC
CGCCTCCGCTCATCGCCCCTCCCCATCGGTTTCCGCGCGAAAAGCCGGGGCGCCTGCGCTGCCGCCGCCGCGTCTGCTGAAGCCTCCGAG
ATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCACACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGAT
TTGGAAAGAGACAGCTTAACAGAAAAGGAATGTGTGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAG
TTATGTGACTTGGAAACCAAATTACGTAAAGAAGAATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTG
TCCTTGGAGAACGGTGCTCATGCTTACAACCGGGAAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTG
GGAATGGCAGATGCCAACAGCCCCCCCAAACCCCTTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCGTTCA
AGAGACCCTCCTGCCTCAGCCTCCCAAGTAACTGGGATTAGAGCTGAACCTTCACCTAGCCCCAGGATTACAAGGAAAAGCACCAGGCAA
ACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCTCAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGTCCATCAAG
GAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGAGAACGAGTTGCTAGACCGCTTCCTGCAGAAGAACCTGAAAGA
GCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAAGAAGAAAAGAGACTCCGAAGTCAAACCAAAGAACCAACACCC
AAACAGAAACTGAAGGAGGAGCCGGACAGAGAAGCCAGGGCAGGCGTGCAGGCTGACGAGGACGAAGATGGAGACGAGAAAGATGAGAAG
AAGCACAGAAGTCAACCCAAAGATCTAGCTGCCAAACGGAGGCCCGAAGAAAAAGAACCTGAAAAAGTAAATCCACAGATTTCTGATGAA
AAAGACGAGGATGAAAAGGACGCAGTGGCCTTTGAGGATGTGGCTGTGAACTTCACCCAGGAGGAATGGGCTTTGCTGGGTCCATCACAG
AAGAATTTATACAGATATGTGATGCAAGAAACCATCAGGAACCTGGACTGTATAAGAATGATATGGGAAGAACAGAATACTGAAGATCAG
TACAAAAATCCTAGGAGAAATCTAAGATGTCATATGGTAGAGAGATTCAGTGAAAGTAAAGACAGTAGTCAGTGTGGAGAAACATTTAGC
CTCATTCGAGATAGTATTGTGAACAACAGCATTTGTCCTGGAGAAGATCCATGTCAAAGCGCTGAGTGTGAAGAAGTCATAATGGGTCAT
TTATCCCTTAATAGCCACATCAGAGTTGATTCTGGACACAAACCACATGAGTATCAGGAATATGGAGAGAAGCCACATACACATAAACAA
CGTGGGAAAGCCTTCAGTTACCATCACTCCTTTCAGTCGCGTGGAAGGCCTCACACTGGAAAGAAACGCTATGAGTGTAAGGAATGTGGA
AAAACCTTCAGTTCTCGTAGAAACCTTCGAAGACACATGGTAGTGCAAGGTGGAAATAGACCTTATAAATTTCCTATCGAAGACATGAGA
GAATGCACACTGGGGAGAAACCGTATGAATGTAAGCAGTGTTCTAAAGCCTTGCCTGATTCCAGTTCCTATATAAGACATGAAAGAACTC

>23705_23705_4_DNMT1-ZNF563_DNMT1_chr19_10273343_ENST00000359526_ZNF563_chr19_12433525_ENST00000595977_length(amino acids)=564AA_BP=149
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDL
SLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKRSRDPPASASQVTGIRAEPSPSPRITRKSTRQ
TTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERAKSGTRTEKEEERDEKEEKRLRSQTKEPTP
KQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQPKDLAAKRRPEEKEPEKVNPQISDEKDEDEKDAVAFEDVAVNFTQEEWALLGPSQ
KNLYRYVMQETIRNLDCIRMIWEEQNTEDQYKNPRRNLRCHMVERFSESKDSSQCGETFSLIRDSIVNNSICPGEDPCQSAECEEVIMGH
LSLNSHIRVDSGHKPHEYQEYGEKPHTHKQRGKAFSYHHSFQSRGRPHTGKKRYECKECGKTFSSRRNLRRHMVVQGGNRPYKFPIEDMR

--------------------------------------------------------------
>23705_23705_5_DNMT1-ZNF563_DNMT1_chr19_10273343_ENST00000540357_ZNF563_chr19_12433525_ENST00000293725_length(transcript)=3685nt_BP=1140nt
GGCTCCGTTCCATCCTTCTGCACAGGGTATCGCCTCTCTCCGTTTGGTACATCCCCTCCTCCCCCACGCCCGGACTGGGGTGGTAGACGC
CGCCTCCGCTCATCGCCCCTCCCCATCGGTTTCCGCGCGAAAAGCCGGGGCGCCTGCGCTGCCGCCGCCGCGTCTGCTGAAGCCTCCGAG
ATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCACACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGAT
TTGGAAAGAGACAGCTTAACAGAAAAGGAATGTGTGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAG
TTATGTGACTTGGAAACCAAATTACGTAAAGAAGAATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTG
TCCTTGGAGAACGGTGCTCATGCTTACAACCGGGAAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTG
GGAATGGCAGATGCCAACAGCCCCCCCAAACCCCTTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCCTGAA
CCTTCACCTAGCCCCAGGATTACAAGGAAAAGCACCAGGCAAACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCT
CAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGTCCATCAAGGAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGA
GAACGAGTTGCTAGACCGCTTCCTGCAGAAGAACCTGAAAGAGCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAA
GAAGAAAAGAGACTCCGAAGTCAAACCAAAGAACCAACACCCAAACAGAAACTGAAGGAGGAGCCGGACAGAGAAGCCAGGGCAGGCGTG
CAGGCTGACGAGGACGAAGATGGAGACGAGAAAGATGAGAAGAAGCACAGAAGTCAACCCAAAGATCTAGCTGCCAAACGGAGGCCCGAA
GAAAAAGAACCTGAAAAAGTAAATCCACAGATTTCTGATGAAAAAGACGAGGATGAAAAGGACGCAGTGGCCTTTGAGGATGTGGCTGTG
AACTTCACCCAGGAGGAATGGGCTTTGCTGGGTCCATCACAGAAGAATTTATACAGATATGTGATGCAAGAAACCATCAGGAACCTGGAC
TGTATAAGAATGATATGGGAAGAACAGAATACTGAAGATCAGTACAAAAATCCTAGGAGAAATCTAAGATGTCATATGGTAGAGAGATTC
AGTGAAAGTAAAGACAGTAGTCAGTGTGGAGAAACATTTAGCCTCATTCGAGATAGTATTGTGAACAACAGCATTTGTCCTGGAGAAGAT
CCATGTCAAAGCGCTGAGTGTGAAGAAGTCATAATGGGTCATTTATCCCTTAATAGCCACATCAGAGTTGATTCTGGACACAAACCACAT
GAGTATCAGGAATATGGAGAGAAGCCACATACACATAAACAACGTGGGAAAGCCTTCAGTTACCATCACTCCTTTCAGTCGCGTGGAAGG
CCTCACACTGGAAAGAAACGCTATGAGTGTAAGGAATGTGGAAAAACCTTCAGTTCTCGTAGAAACCTTCGAAGACACATGGTAGTGCAA
GGTGGAAATAGACCTTATAAATGTAAGTTGTGTGGGAAAGCTTTTTTTTGGCCCAGTTTATTACGTATGCATGAAAGAACTCACACTGGA
GAGAAACCGTATGAATGTAAGCAGTGTTCTAAAGCCTTTCCTTTTTACAGTTCCTATCGAAGACATGAGAGAATGCACACTGGGGAGAAA
CCGTATGAATGTAAGCAGTGTTCTAAAGCCTTGCCTGATTCCAGTTCCTATATAAGACATGAAAGAACTCACACTGGAGAGAAACCATAT
ACATGTAAACAGTGTGGGAAAGCCTTCAGTGTTTCCAGTTCCCTTCGAAGACATGAAACCACTCACAGTGCAGAGAAACCCTATGAGTGT
AAGCAATGCGGGAAAACATTTCATCATCTTGGAAGCTTTCAGATACACATGAAAAGGCACACTGGAGATCGACCTCATAAATGTAAGATA
TGTGGGAAAGGCTTTGATCGTCCCAGTTTAGTTCGATATCATGAACGAATTCACACTGGAGAGAAACCCTATGAATGCAAGCAGTGTGGG
AAAACGTTATCTCATAGCTCAAGCTTTCGAAGACACATGATAATGCACACTGGAGGTGGACCTCATAAATGCAAGATATGTGGGAAAGCT
TTTGTTTATCCTAGTGTATGTCAAAGACACGAAAAGTCTCACAGTGGAGAGAAACCCTATGAATGCAAGCAGTGTGGGAAAGCGTTATCT
CATAGCTCAAGCTTTCGAAGACATATGGTAATGCATACGGGAGATGGGCCGAATAAATGCAAGGTATGTGGGAAAGCCTTTGTTTATCCC
AGTGTATGTCAAAGACATGAAAAGACTCACTGGAGAGAAACAATATGAATGTAAACTATTATAAAGCCTTCTATATTTCCAGTTCCCTTT
GATATCATGAATAAACTTACACTGGACAGAAACCCTATAAATGTAAATGTGGGAAAGCCTTTCATAATTTTTATTCCTTTCAAAATCATG
AAATATCTCACACTGGAGAGATGCTGTATGATATAAGGAATGTGGGAAAGTGATCGATTTTTTTTTAACACCATTGTCAACATAAAACAA
CTCACAGAGCAGAAAAACTCTGTGAGTGTAAAATATGTAGGGAAGCCTTCAGTCATTTTGGTAACTTAAAAGTACATGAGGCTGGGCACA
GTGGCTCACGCCTGTAATCCCAGCACTTAGGGTGGGCAAATTGCTTGACCTCAGGAATTTGAGGCCTGCCTGGGCAAAATGGTGAAACCA
TGTCTCTACAAAAAATAGAAAAAGTAGCAGGTGTGGTGGTATGCCCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGTGGGAAGATCTCTT
GAGCCCAAGGGGTGGGGGTTGCAGTGAGCCAAGATGCACTGCACCCCAGCCTGGGCGACAGAGCCAGACCCTGTCTCAAAAAAAAAAAAA
AAGTACATGAAAGGATTCACTCTGGAGAGAAGTCATATGAATGTAAGAAATGTAGAAAAGCATTGAGTTCTCTCAGGTCCTTGCATAGAC
ATAAAAGGACTCACTGGAGAGATACTCTATAAATGTGTGAAATGTAGGGAAGTATTCTTTAATGTTATTTCATTTCAGATAGAAATAATT
CTCATTGGAGATAAACCCTATGAATGTAAACACATAGTAAAGCCTTAATTTTAAGCCTCAGTTTCTTTCAAATACAGTTATCCCCTAATA
TTTGCAGGAGCGTGGTTCTACCACCCCCTGGGCATACATAAATCGACACATGCCAAGTCCTTTTTTAAAAATGACATATTTGGTACAAAA
TTACCCGGATGTGATGGCACATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGATAATCACTTGAATCCGGGAGGCGGAGGTTGC

>23705_23705_5_DNMT1-ZNF563_DNMT1_chr19_10273343_ENST00000540357_ZNF563_chr19_12433525_ENST00000293725_length(amino acids)=795AA_BP=322
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDL
SLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKP
QEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERAKSGTRTEKEEERDEKEEKRLRSQTKEPTPKQKLKEEPDREARAGV
QADEDEDGDEKDEKKHRSQPKDLAAKRRPEEKEPEKVNPQISDEKDEDEKDAVAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNLD
CIRMIWEEQNTEDQYKNPRRNLRCHMVERFSESKDSSQCGETFSLIRDSIVNNSICPGEDPCQSAECEEVIMGHLSLNSHIRVDSGHKPH
EYQEYGEKPHTHKQRGKAFSYHHSFQSRGRPHTGKKRYECKECGKTFSSRRNLRRHMVVQGGNRPYKCKLCGKAFFWPSLLRMHERTHTG
EKPYECKQCSKAFPFYSSYRRHERMHTGEKPYECKQCSKALPDSSSYIRHERTHTGEKPYTCKQCGKAFSVSSSLRRHETTHSAEKPYEC
KQCGKTFHHLGSFQIHMKRHTGDRPHKCKICGKGFDRPSLVRYHERIHTGEKPYECKQCGKTLSHSSSFRRHMIMHTGGGPHKCKICGKA

--------------------------------------------------------------
>23705_23705_6_DNMT1-ZNF563_DNMT1_chr19_10273343_ENST00000540357_ZNF563_chr19_12433525_ENST00000595977_length(transcript)=1857nt_BP=1140nt
GGCTCCGTTCCATCCTTCTGCACAGGGTATCGCCTCTCTCCGTTTGGTACATCCCCTCCTCCCCCACGCCCGGACTGGGGTGGTAGACGC
CGCCTCCGCTCATCGCCCCTCCCCATCGGTTTCCGCGCGAAAAGCCGGGGCGCCTGCGCTGCCGCCGCCGCGTCTGCTGAAGCCTCCGAG
ATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCACACTGGCCGTCCCGGCCATCTCGCTGCCCGACGATGTCCGCAGGCGGCTCAAAGAT
TTGGAAAGAGACAGCTTAACAGAAAAGGAATGTGTGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAG
TTATGTGACTTGGAAACCAAATTACGTAAAGAAGAATTATCCGAGGAGGGCTACCTGGCTAAAGTCAAATCCCTTTTAAATAAAGATTTG
TCCTTGGAGAACGGTGCTCATGCTTACAACCGGGAAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTG
GGAATGGCAGATGCCAACAGCCCCCCCAAACCCCTTTCCAAACCTCGCACGCCCAGGAGGAGCAAGTCCGATGGAGAGGCTAAGCCTGAA
CCTTCACCTAGCCCCAGGATTACAAGGAAAAGCACCAGGCAAACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCT
CAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGTCCATCAAGGAAGAAGACAAAGACCAGGATGAGAAGAGACGTAGAGTTACATCCAGA
GAACGAGTTGCTAGACCGCTTCCTGCAGAAGAACCTGAAAGAGCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAA
GAAGAAAAGAGACTCCGAAGTCAAACCAAAGAACCAACACCCAAACAGAAACTGAAGGAGGAGCCGGACAGAGAAGCCAGGGCAGGCGTG
CAGGCTGACGAGGACGAAGATGGAGACGAGAAAGATGAGAAGAAGCACAGAAGTCAACCCAAAGATCTAGCTGCCAAACGGAGGCCCGAA
GAAAAAGAACCTGAAAAAGTAAATCCACAGATTTCTGATGAAAAAGACGAGGATGAAAAGGACGCAGTGGCCTTTGAGGATGTGGCTGTG
AACTTCACCCAGGAGGAATGGGCTTTGCTGGGTCCATCACAGAAGAATTTATACAGATATGTGATGCAAGAAACCATCAGGAACCTGGAC
TGTATAAGAATGATATGGGAAGAACAGAATACTGAAGATCAGTACAAAAATCCTAGGAGAAATCTAAGATGTCATATGGTAGAGAGATTC
AGTGAAAGTAAAGACAGTAGTCAGTGTGGAGAAACATTTAGCCTCATTCGAGATAGTATTGTGAACAACAGCATTTGTCCTGGAGAAGAT
CCATGTCAAAGCGCTGAGTGTGAAGAAGTCATAATGGGTCATTTATCCCTTAATAGCCACATCAGAGTTGATTCTGGACACAAACCACAT
GAGTATCAGGAATATGGAGAGAAGCCACATACACATAAACAACGTGGGAAAGCCTTCAGTTACCATCACTCCTTTCAGTCGCGTGGAAGG
CCTCACACTGGAAAGAAACGCTATGAGTGTAAGGAATGTGGAAAAACCTTCAGTTCTCGTAGAAACCTTCGAAGACACATGGTAGTGCAA
GGTGGAAATAGACCTTATAAATTTCCTATCGAAGACATGAGAGAATGCACACTGGGGAGAAACCGTATGAATGTAAGCAGTGTTCTAAAG

>23705_23705_6_DNMT1-ZNF563_DNMT1_chr19_10273343_ENST00000540357_ZNF563_chr19_12433525_ENST00000595977_length(amino acids)=548AA_BP=325
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDL
SLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKP
QEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERAKSGTRTEKEEERDEKEEKRLRSQTKEPTPKQKLKEEPDREARAGV
QADEDEDGDEKDEKKHRSQPKDLAAKRRPEEKEPEKVNPQISDEKDEDEKDAVAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNLD
CIRMIWEEQNTEDQYKNPRRNLRCHMVERFSESKDSSQCGETFSLIRDSIVNNSICPGEDPCQSAECEEVIMGHLSLNSHIRVDSGHKPH
EYQEYGEKPHTHKQRGKAFSYHHSFQSRGRPHTGKKRYECKECGKTFSSRRNLRRHMVVQGGNRPYKFPIEDMRECTLGRNRMNVSSVLK

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Fusion Gene PPI Analysis for DNMT1-ZNF563


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401_120320.01617.0DMAP1
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411_120336.01633.0DMAP1
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401_148320.01617.0DNMT3A
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411_148336.01633.0DNMT3A
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-1240149_217320.01617.0DNMT3B
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-1341149_217336.01633.0DNMT3B
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-1240163_174320.01617.0PCNA
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-1341163_174336.01633.0PCNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-12401121_1616320.01617.0the PRC2/EED-EZH2 complex
HgeneDNMT1chr19:10273343chr19:12433525ENST00000340748-1240308_606320.01617.0the PRC2/EED-EZH2 complex
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-13411121_1616336.01633.0the PRC2/EED-EZH2 complex
HgeneDNMT1chr19:10273343chr19:12433525ENST00000359526-1341308_606336.01633.0the PRC2/EED-EZH2 complex


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DNMT1-ZNF563


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DNMT1-ZNF563


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource