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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DOCK10-IL1RN (FusionGDB2 ID:23745)

Fusion Gene Summary for DOCK10-IL1RN

check button Fusion gene summary
Fusion gene informationFusion gene name: DOCK10-IL1RN
Fusion gene ID: 23745
HgeneTgene
Gene symbol

DOCK10

IL1RN

Gene ID

55619

3557

Gene namededicator of cytokinesis 10interleukin 1 receptor antagonist
SynonymsDRIP2|Nbla10300|ZIZ3DIRA|ICIL-1RA|IL-1RN|IL-1ra|IL-1ra3|IL1F3|IL1RA|IRAP|MVCD4
Cytomap

2q36.2

2q14.1

Type of geneprotein-codingprotein-coding
Descriptiondedicator of cytokinesis protein 10dopamine receptor interacting protein 2zizimin3interleukin-1 receptor antagonist proteinIL1 inhibitorintracellular IL-1 receptor antagonist type IIintracellular interleukin-1 receptor antagonist (icIL-1ra)type II interleukin-1 receptor antagonist
Modification date2020031320200329
UniProtAcc

Q96BY6

P18510

Ensembl transtripts involved in fusion geneENST00000258390, ENST00000409592, 
ENST00000474102, 		ENST00000259206, 
ENST00000354115, ENST00000361779, 
ENST00000409052, ENST00000409930, 
ENST00000465812, 
Fusion gene scores* DoF score5 X 5 X 2=508 X 5 X 7=280
# samples 510
** MAII scorelog2(5/50*10)=0log2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DOCK10 [Title/Abstract] AND IL1RN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDOCK10(225796266)-IL1RN(113885266), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDOCK10

GO:0030334

regulation of cell migration

18835169

TgeneIL1RN

GO:0034115

negative regulation of heterotypic cell-cell adhesion

2139180

TgeneIL1RN

GO:0051384

response to glucocorticoid

10443688

TgeneIL1RN

GO:2000660

negative regulation of interleukin-1-mediated signaling pathway

2137200|2139180


check buttonFusion gene breakpoints across DOCK10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across IL1RN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-TQ-A7RH-01ADOCK10chr2

225796266

-IL1RNchr2

113885266

+
ChimerDB4LGGTCGA-TQ-A7RHDOCK10chr2

225796266

-IL1RNchr2

113885266

+


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Fusion Gene ORF analysis for DOCK10-IL1RN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000258390ENST00000259206DOCK10chr2

225796266

-IL1RNchr2

113885266

+
5CDS-5UTRENST00000258390ENST00000354115DOCK10chr2

225796266

-IL1RNchr2

113885266

+
5CDS-5UTRENST00000258390ENST00000361779DOCK10chr2

225796266

-IL1RNchr2

113885266

+
5CDS-5UTRENST00000258390ENST00000409052DOCK10chr2

225796266

-IL1RNchr2

113885266

+
5CDS-5UTRENST00000258390ENST00000409930DOCK10chr2

225796266

-IL1RNchr2

113885266

+
5CDS-5UTRENST00000409592ENST00000259206DOCK10chr2

225796266

-IL1RNchr2

113885266

+
5CDS-5UTRENST00000409592ENST00000354115DOCK10chr2

225796266

-IL1RNchr2

113885266

+
5CDS-5UTRENST00000409592ENST00000361779DOCK10chr2

225796266

-IL1RNchr2

113885266

+
5CDS-5UTRENST00000409592ENST00000409052DOCK10chr2

225796266

-IL1RNchr2

113885266

+
5CDS-5UTRENST00000409592ENST00000409930DOCK10chr2

225796266

-IL1RNchr2

113885266

+
5CDS-intronENST00000258390ENST00000465812DOCK10chr2

225796266

-IL1RNchr2

113885266

+
5CDS-intronENST00000409592ENST00000465812DOCK10chr2

225796266

-IL1RNchr2

113885266

+
5UTR-5UTRENST00000474102ENST00000259206DOCK10chr2

225796266

-IL1RNchr2

113885266

+
5UTR-5UTRENST00000474102ENST00000354115DOCK10chr2

225796266

-IL1RNchr2

113885266

+
5UTR-5UTRENST00000474102ENST00000361779DOCK10chr2

225796266

-IL1RNchr2

113885266

+
5UTR-5UTRENST00000474102ENST00000409052DOCK10chr2

225796266

-IL1RNchr2

113885266

+
5UTR-5UTRENST00000474102ENST00000409930DOCK10chr2

225796266

-IL1RNchr2

113885266

+
5UTR-intronENST00000474102ENST00000465812DOCK10chr2

225796266

-IL1RNchr2

113885266

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DOCK10-IL1RN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DOCK10chr2225796265-IL1RNchr2113885265+1.36E-050.9999864
DOCK10chr2225796265-IL1RNchr2113885265+1.36E-050.9999864
DOCK10chr2225796265-IL1RNchr2113885265+1.36E-050.9999864
DOCK10chr2225796265-IL1RNchr2113885265+1.36E-050.9999864

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DOCK10-IL1RN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:225796266/:113885266)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DOCK10

Q96BY6

IL1RN

P18510

FUNCTION: Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}.FUNCTION: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. {ECO:0000269|PubMed:7775431}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DOCK10-IL1RN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DOCK10-IL1RN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DOCK10-IL1RN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DOCK10-IL1RN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource